TSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.20188279
2viral transcription (GO:0019083)4.62087552
3translational termination (GO:0006415)4.44349519
4ribosomal small subunit biogenesis (GO:0042274)4.42763065
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32837371
6maturation of SSU-rRNA (GO:0030490)4.30767142
7ribosome assembly (GO:0042255)4.21308245
8DNA double-strand break processing (GO:0000729)4.20055182
9proteasome assembly (GO:0043248)4.15324742
10cotranslational protein targeting to membrane (GO:0006613)4.08392146
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.07101116
12protein localization to kinetochore (GO:0034501)4.06186597
13ATP synthesis coupled proton transport (GO:0015986)4.01310151
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01310151
15protein targeting to ER (GO:0045047)3.99586491
16ribosomal large subunit biogenesis (GO:0042273)3.96752263
17mitotic metaphase plate congression (GO:0007080)3.87696498
18cullin deneddylation (GO:0010388)3.82566480
19translational elongation (GO:0006414)3.80078550
20telomere maintenance via semi-conservative replication (GO:0032201)3.79674655
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.79487369
22double-strand break repair via nonhomologous end joining (GO:0006303)3.79103416
23non-recombinational repair (GO:0000726)3.79103416
24protein localization to endoplasmic reticulum (GO:0070972)3.78551250
25histone exchange (GO:0043486)3.77924964
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.74757237
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.74757237
28mitotic sister chromatid cohesion (GO:0007064)3.73256910
29IMP biosynthetic process (GO:0006188)3.71539810
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.68378528
31termination of RNA polymerase III transcription (GO:0006386)3.68378528
32cellular protein complex disassembly (GO:0043624)3.67389679
33regulation of helicase activity (GO:0051095)3.64598508
34nuclear pore complex assembly (GO:0051292)3.60692498
35metaphase plate congression (GO:0051310)3.60651597
36DNA strand elongation involved in DNA replication (GO:0006271)3.59641541
37protein localization to chromosome, centromeric region (GO:0071459)3.59164655
38translational initiation (GO:0006413)3.58065774
39DNA deamination (GO:0045006)3.56141723
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.55051662
41viral life cycle (GO:0019058)3.55000114
42establishment of integrated proviral latency (GO:0075713)3.54889707
43spliceosomal complex assembly (GO:0000245)3.54639977
44RNA capping (GO:0036260)3.53456555
457-methylguanosine RNA capping (GO:0009452)3.53456555
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53365185
47spliceosomal snRNP assembly (GO:0000387)3.53356749
48DNA damage response, detection of DNA damage (GO:0042769)3.52900762
497-methylguanosine mRNA capping (GO:0006370)3.52371450
50spindle checkpoint (GO:0031577)3.50867825
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49992089
52viral mRNA export from host cell nucleus (GO:0046784)3.49761773
53chaperone-mediated protein transport (GO:0072321)3.45933576
54mitotic recombination (GO:0006312)3.45685766
55protein deneddylation (GO:0000338)3.45634715
56nuclear pore organization (GO:0006999)3.45510122
57mitotic spindle checkpoint (GO:0071174)3.44496432
58telomere maintenance via recombination (GO:0000722)3.44391945
59DNA strand elongation (GO:0022616)3.43122792
60DNA unwinding involved in DNA replication (GO:0006268)3.42229178
61protein neddylation (GO:0045116)3.42125647
62DNA catabolic process, exonucleolytic (GO:0000738)3.41756942
63CENP-A containing nucleosome assembly (GO:0034080)3.41612712
64regulation of meiosis I (GO:0060631)3.33298783
65formation of translation preinitiation complex (GO:0001731)3.32206556
66purine nucleobase biosynthetic process (GO:0009113)3.30853784
67chromatin remodeling at centromere (GO:0031055)3.30496233
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29555536
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28851090
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.28851090
71negative regulation of sister chromatid segregation (GO:0033046)3.28851090
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28851090
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.28851090
74mitotic sister chromatid segregation (GO:0000070)3.28635010
75transcription-coupled nucleotide-excision repair (GO:0006283)3.28576422
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28410347
77negative regulation of DNA recombination (GO:0045910)3.28323979
78regulation of mitotic spindle checkpoint (GO:1903504)3.28322530
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.28322530
80negative regulation of chromosome segregation (GO:0051985)3.28041992
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27792227
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27253437
83tRNA aminoacylation for protein translation (GO:0006418)3.27185218
84IMP metabolic process (GO:0046040)3.27176480
85translation (GO:0006412)3.27016530
86protein complex disassembly (GO:0043241)3.26938356
87GTP biosynthetic process (GO:0006183)3.26106150
88ribonucleoprotein complex biogenesis (GO:0022613)3.24676934
89amino acid activation (GO:0043038)3.23066334
90tRNA aminoacylation (GO:0043039)3.23066334
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22840020
92negative regulation of ligase activity (GO:0051352)3.22840020
93regulation of centriole replication (GO:0046599)3.21681455
94nucleobase biosynthetic process (GO:0046112)3.20144448
95DNA replication initiation (GO:0006270)3.18999910
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18880602
97macromolecular complex disassembly (GO:0032984)3.17863546
98DNA replication-dependent nucleosome assembly (GO:0006335)3.17069134
99DNA replication-dependent nucleosome organization (GO:0034723)3.17069134
100DNA replication checkpoint (GO:0000076)3.16660962
101nucleotide-excision repair, DNA gap filling (GO:0006297)3.16410617
102spindle assembly checkpoint (GO:0071173)3.14996175
103regulation of chromosome segregation (GO:0051983)3.14856361
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14736880
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14724003
106kinetochore organization (GO:0051383)3.13847850
107regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13459786
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13459786
109sister chromatid segregation (GO:0000819)3.13426418
110mitotic spindle assembly checkpoint (GO:0007094)3.12904161
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12863787
112establishment of chromosome localization (GO:0051303)3.12511882
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10071505
114mitochondrial respiratory chain complex I assembly (GO:0032981)3.10071505
115NADH dehydrogenase complex assembly (GO:0010257)3.10071505
116mitotic nuclear envelope disassembly (GO:0007077)3.08675575
117maturation of 5.8S rRNA (GO:0000460)3.07922187
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06127465
119somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06127465
120isotype switching (GO:0045190)3.06127465
121regulation of mitotic sister chromatid separation (GO:0010965)3.05942009
122regulation of mitotic sister chromatid segregation (GO:0033047)3.05942009
123regulation of sister chromatid segregation (GO:0033045)3.05942009
124regulation of centrosome cycle (GO:0046605)3.05579049
125histone H2A acetylation (GO:0043968)3.04301570
126regulation of DNA endoreduplication (GO:0032875)3.03697267
127transcription elongation from RNA polymerase I promoter (GO:0006362)3.03692415
128kinetochore assembly (GO:0051382)3.02578907
129DNA ligation (GO:0006266)3.02515915
130protein complex biogenesis (GO:0070271)3.01749701
131attachment of spindle microtubules to kinetochore (GO:0008608)3.01528630
132mitotic chromosome condensation (GO:0007076)3.01440687
133telomere maintenance via telomere lengthening (GO:0010833)3.01328816
134mitochondrial RNA metabolic process (GO:0000959)2.99581142
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98913550
136rRNA processing (GO:0006364)2.98704851
137postreplication repair (GO:0006301)2.97213295
138somatic recombination of immunoglobulin gene segments (GO:0016447)2.95283190
139guanosine-containing compound biosynthetic process (GO:1901070)2.95036527
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94564564
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94564564
142UTP biosynthetic process (GO:0006228)2.94357643
143DNA replication-independent nucleosome assembly (GO:0006336)2.94136997
144DNA replication-independent nucleosome organization (GO:0034724)2.94136997
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.94092857
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.94092857
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.94092857
148cellular component biogenesis (GO:0044085)2.94071141
149synapsis (GO:0007129)2.93569679
150signal transduction involved in cell cycle checkpoint (GO:0072395)2.92533456
151cell cycle G1/S phase transition (GO:0044843)2.92434779
152G1/S transition of mitotic cell cycle (GO:0000082)2.92434779
153termination of RNA polymerase II transcription (GO:0006369)2.91893814
154regulation of cellular amino acid metabolic process (GO:0006521)2.91816484
155positive regulation of chromosome segregation (GO:0051984)2.91046793
156regulation of spindle organization (GO:0090224)2.90984467
157rRNA metabolic process (GO:0016072)2.89884246
158positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88952231
159establishment of viral latency (GO:0019043)2.88568950
160signal transduction involved in DNA damage checkpoint (GO:0072422)2.88453975
161signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88453975
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87478263
163RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87478263
164nuclear-transcribed mRNA catabolic process (GO:0000956)2.87356419
165respiratory electron transport chain (GO:0022904)2.87210439
166peptidyl-arginine omega-N-methylation (GO:0035247)2.86674247
167histone mRNA metabolic process (GO:0008334)2.81853008
168mitochondrial respiratory chain complex assembly (GO:0033108)2.81112126
169electron transport chain (GO:0022900)2.79861025
170pseudouridine synthesis (GO:0001522)2.76668882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.65867725
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13907091
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98969697
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.69637189
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.56995972
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.55457735
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.46269896
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12845786
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11959170
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09622526
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.97091010
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86342103
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74718673
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66137888
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65604199
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.64575216
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63317687
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61323905
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54449202
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53878882
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53469088
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48849224
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29408393
24* VDR_23849224_ChIP-Seq_CD4+_Human2.25428851
25XRN2_22483619_ChIP-Seq_HELA_Human2.25153197
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24492952
27TTF2_22483619_ChIP-Seq_HELA_Human2.18915195
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18699211
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17769575
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10830446
31ELK1_19687146_ChIP-ChIP_HELA_Human2.09331600
32* DCP1A_22483619_ChIP-Seq_HELA_Human2.05143021
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.99710829
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98989529
35EZH2_22144423_ChIP-Seq_EOC_Human1.91519131
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90145688
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88260255
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.80163742
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77272418
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76083565
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75807176
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.68489868
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68069162
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.65441385
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64798889
46GABP_19822575_ChIP-Seq_HepG2_Human1.64398041
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58011876
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53487926
49ZNF274_21170338_ChIP-Seq_K562_Hela1.53189540
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53046929
51MYC_18940864_ChIP-ChIP_HL60_Human1.52869571
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49137061
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48919675
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45208664
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.45198011
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42401511
57EWS_26573619_Chip-Seq_HEK293_Human1.34623143
58FUS_26573619_Chip-Seq_HEK293_Human1.34485506
59TAF15_26573619_Chip-Seq_HEK293_Human1.33138717
60IRF1_19129219_ChIP-ChIP_H3396_Human1.32355513
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30847895
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.29471765
63CIITA_25753668_ChIP-Seq_RAJI_Human1.28693931
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27567087
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26277724
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24634814
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23791265
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23752195
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23752037
70IGF1R_20145208_ChIP-Seq_DFB_Human1.22820523
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.18791226
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.17649467
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12516481
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12086363
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10680910
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09781467
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.07078938
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06477074
79VDR_22108803_ChIP-Seq_LS180_Human1.04914093
80* RNF2_27304074_Chip-Seq_NSC_Mouse1.04668204
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04224286
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03861385
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02913681
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01046220
85* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97744781
86* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94540882
87KDM5A_27292631_Chip-Seq_BREAST_Human0.91305486
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88937007
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88730642
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.87936695
91* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87523230
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86564107
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86223363
94* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84839371
95TFEB_21752829_ChIP-Seq_HELA_Human0.84797342
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83908384
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.83641613
98* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83557527
99* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83493260
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83325671
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82517487
102POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81845657
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81739027
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81469027
105* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81305445
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81107378
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80771420
108AR_21909140_ChIP-Seq_LNCAP_Human0.80372053
109CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79959902
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78537152
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.78161694
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77560605
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75891980
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74903234
115P300_19829295_ChIP-Seq_ESCs_Human0.74421781
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73643693
117* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72281965
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71345416
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69611660
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69611660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.03462685
2MP0003880_abnormal_central_pattern2.94956038
3MP0006292_abnormal_olfactory_placode2.94229450
4MP0001188_hyperpigmentation2.86285264
5MP0003693_abnormal_embryo_hatching2.67473805
6MP0010094_abnormal_chromosome_stability2.55566063
7MP0006276_abnormal_autonomic_nervous2.52020111
8MP0001529_abnormal_vocalization2.47172118
9MP0002638_abnormal_pupillary_reflex2.45277265
10MP0008058_abnormal_DNA_repair2.42525257
11MP0004957_abnormal_blastocyst_morpholog2.35718557
12MP0008057_abnormal_DNA_replication2.32663915
13MP0009697_abnormal_copulation2.18499132
14MP0003111_abnormal_nucleus_morphology2.12184947
15MP0001730_embryonic_growth_arrest2.03924700
16MP0008932_abnormal_embryonic_tissue2.03549703
17MP0002751_abnormal_autonomic_nervous1.90408363
18MP0003077_abnormal_cell_cycle1.89437318
19MP0008007_abnormal_cellular_replicative1.88311449
20MP0002102_abnormal_ear_morphology1.88087862
21MP0008877_abnormal_DNA_methylation1.87960396
22MP0003315_abnormal_perineum_morphology1.87423882
23MP0008789_abnormal_olfactory_epithelium1.84931058
24MP0005409_darkened_coat_color1.80495866
25MP0003941_abnormal_skin_development1.79455816
26MP0001905_abnormal_dopamine_level1.79292841
27MP0003123_paternal_imprinting1.79063421
28MP0003122_maternal_imprinting1.78978562
29MP0002938_white_spotting1.78928509
30MP0003121_genomic_imprinting1.78530236
31MP0005423_abnormal_somatic_nervous1.71697552
32MP0003567_abnormal_fetal_cardiomyocyte1.71261964
33MP0010307_abnormal_tumor_latency1.69572737
34MP0003806_abnormal_nucleotide_metabolis1.60834183
35MP0000049_abnormal_middle_ear1.59368627
36MP0003786_premature_aging1.59083068
37MP0001697_abnormal_embryo_size1.58014005
38MP0000778_abnormal_nervous_system1.53027666
39MP0005499_abnormal_olfactory_system1.48417579
40MP0005394_taste/olfaction_phenotype1.48417579
41MP0001672_abnormal_embryogenesis/_devel1.46912370
42MP0005380_embryogenesis_phenotype1.46912370
43MP0002084_abnormal_developmental_patter1.46315566
44MP0003136_yellow_coat_color1.45832037
45MP0000631_abnormal_neuroendocrine_gland1.45638109
46MP0001986_abnormal_taste_sensitivity1.44251092
47MP0001293_anophthalmia1.43416388
48MP0004147_increased_porphyrin_level1.42579095
49MP0002080_prenatal_lethality1.38143840
50MP0002163_abnormal_gland_morphology1.36386037
51MP0006072_abnormal_retinal_apoptosis1.34814431
52MP0010352_gastrointestinal_tract_polyps1.34297372
53MP0002085_abnormal_embryonic_tissue1.32746167
54MP0006036_abnormal_mitochondrial_physio1.32048846
55MP0002184_abnormal_innervation1.31407972
56MP0005174_abnormal_tail_pigmentation1.30131162
57MP0001968_abnormal_touch/_nociception1.28893937
58MP0004197_abnormal_fetal_growth/weight/1.26717482
59MP0000015_abnormal_ear_pigmentation1.25395666
60MP0003787_abnormal_imprinting1.24805072
61MP0002736_abnormal_nociception_after1.24572112
62MP0004142_abnormal_muscle_tone1.24334057
63MP0000566_synostosis1.24190703
64MP0003186_abnormal_redox_activity1.24137189
65* MP0001929_abnormal_gametogenesis1.21640948
66MP0003984_embryonic_growth_retardation1.21312259
67MP0000358_abnormal_cell_content/1.20194399
68MP0000313_abnormal_cell_death1.17668333
69MP0002088_abnormal_embryonic_growth/wei1.17660623
70* MP0009672_abnormal_birth_weight1.16739704
71MP0000372_irregular_coat_pigmentation1.14110027
72MP0003938_abnormal_ear_development1.13267021
73MP0002734_abnormal_mechanical_nocicepti1.13012927
74MP0002095_abnormal_skin_pigmentation1.08649906
75MP0010030_abnormal_orbit_morphology1.06040897
76MP0002557_abnormal_social/conspecific_i1.05341519
77MP0009250_abnormal_appendicular_skeleto1.04790064
78MP0000026_abnormal_inner_ear1.04137371
79MP0002735_abnormal_chemical_nociception1.03866104
80* MP0000653_abnormal_sex_gland1.03047604
81MP0005171_absent_coat_pigmentation1.02905906
82MP0005645_abnormal_hypothalamus_physiol1.01247457
83MP0001984_abnormal_olfaction1.00035863
84MP0003718_maternal_effect0.99989056
85MP0002160_abnormal_reproductive_system0.99511464
86MP0009745_abnormal_behavioral_response0.99475328
87MP0002210_abnormal_sex_determination0.98213067
88MP0001177_atelectasis0.97400372
89MP0003937_abnormal_limbs/digits/tail_de0.96018612
90MP0002086_abnormal_extraembryonic_tissu0.95809984
91MP0002111_abnormal_tail_morphology0.95648117
92MP0003861_abnormal_nervous_system0.95189772
93MP0003385_abnormal_body_wall0.94488893
94MP0000516_abnormal_urinary_system0.93745348
95MP0005367_renal/urinary_system_phenotyp0.93745348
96MP0002067_abnormal_sensory_capabilities0.93554009
97MP0003221_abnormal_cardiomyocyte_apopto0.92136201
98MP0002752_abnormal_somatic_nervous0.91926660
99MP0002177_abnormal_outer_ear0.91454902
100MP0004215_abnormal_myocardial_fiber0.90193357
101MP0004270_analgesia0.90172452
102MP0002272_abnormal_nervous_system0.90095172
103MP0003635_abnormal_synaptic_transmissio0.89744438
104MP0003890_abnormal_embryonic-extraembry0.89374720
105MP0004133_heterotaxia0.89175742
106MP0001485_abnormal_pinna_reflex0.89121206
107* MP0002572_abnormal_emotion/affect_behav0.89066426
108MP0001286_abnormal_eye_development0.88667014
109MP0005253_abnormal_eye_physiology0.87918220
110* MP0009703_decreased_birth_body0.87783221
111MP0008995_early_reproductive_senescence0.87187414
112MP0002063_abnormal_learning/memory/cond0.82318207
113MP0001963_abnormal_hearing_physiology0.82272689
114MP0000537_abnormal_urethra_morphology0.82180295
115MP0010386_abnormal_urinary_bladder0.81707530
116* MP0000350_abnormal_cell_proliferation0.80942140
117MP0005379_endocrine/exocrine_gland_phen0.80663883
118MP0006035_abnormal_mitochondrial_morpho0.80111868
119MP0002064_seizures0.80048972
120MP0003755_abnormal_palate_morphology0.79566924
121MP0002277_abnormal_respiratory_mucosa0.78938076
122MP0005075_abnormal_melanosome_morpholog0.78688771
123MP0004742_abnormal_vestibular_system0.78024678
124MP0002152_abnormal_brain_morphology0.77995214
125MP0001486_abnormal_startle_reflex0.77720440
126MP0001119_abnormal_female_reproductive0.77464721
127* MP0003698_abnormal_male_reproductive0.77372477
128MP0002233_abnormal_nose_morphology0.76785159
129MP0001661_extended_life_span0.75412837
130MP0001970_abnormal_pain_threshold0.75303137
131MP0002882_abnormal_neuron_morphology0.75272133
132MP0003119_abnormal_digestive_system0.75088608
133MP0002697_abnormal_eye_size0.74494534
134MP0003942_abnormal_urinary_system0.74407233
135MP0003943_abnormal_hepatobiliary_system0.74339124
136MP0001764_abnormal_homeostasis0.74083442
137MP0004924_abnormal_behavior0.73482653
138MP0005386_behavior/neurological_phenoty0.73482653
139MP0002019_abnormal_tumor_incidence0.73162183
140MP0010368_abnormal_lymphatic_system0.72197658
141* MP0001145_abnormal_male_reproductive0.72168111
142MP0000647_abnormal_sebaceous_gland0.71573360
143MP0002282_abnormal_trachea_morphology0.71145136
144MP0005395_other_phenotype0.70040374
145MP0010234_abnormal_vibrissa_follicle0.68228276
146MP0005391_vision/eye_phenotype0.68041769
147MP0005384_cellular_phenotype0.67343798
148MP0005501_abnormal_skin_physiology0.64227214
149* MP0002161_abnormal_fertility/fecundity0.57100138
150MP0005220_abnormal_exocrine_pancreas0.56542229
151MP0004782_abnormal_surfactant_physiolog0.56152340
152MP0002877_abnormal_melanocyte_morpholog0.54384531
153MP0002396_abnormal_hematopoietic_system0.53839906

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.10512227
2Reticulocytopenia (HP:0001896)3.90001148
3Mitochondrial inheritance (HP:0001427)3.80222336
4Abnormality of cells of the erythroid lineage (HP:0012130)3.78481337
5Abnormal number of erythroid precursors (HP:0012131)3.71230164
6Medulloblastoma (HP:0002885)3.70366609
7Abnormal mitochondria in muscle tissue (HP:0008316)3.55773012
8Progressive macrocephaly (HP:0004481)3.49086502
9Volvulus (HP:0002580)3.46780738
10Hepatocellular necrosis (HP:0001404)3.41683450
11Rhabdomyosarcoma (HP:0002859)3.31793859
12Increased hepatocellular lipid droplets (HP:0006565)3.26351249
13Birth length less than 3rd percentile (HP:0003561)3.21553992
14Increased CSF lactate (HP:0002490)3.20596372
15Ependymoma (HP:0002888)3.08831514
16Abnormality of chromosome stability (HP:0003220)3.05776188
17Macrocytic anemia (HP:0001972)2.92260164
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.79010435
19Acute encephalopathy (HP:0006846)2.74841132
20Glioma (HP:0009733)2.71840248
21Cortical dysplasia (HP:0002539)2.71764702
22Abnormality of methionine metabolism (HP:0010901)2.70350652
23Renal Fanconi syndrome (HP:0001994)2.68304677
24Pallor (HP:0000980)2.66709440
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62690437
26Limb dystonia (HP:0002451)2.62307078
27Nephroblastoma (Wilms tumor) (HP:0002667)2.56246883
28Lipid accumulation in hepatocytes (HP:0006561)2.50294752
29Aplastic anemia (HP:0001915)2.49949416
30Small intestinal stenosis (HP:0012848)2.49278954
31Duodenal stenosis (HP:0100867)2.49278954
32Embryonal renal neoplasm (HP:0011794)2.49275339
33Increased nuchal translucency (HP:0010880)2.47614376
34Hepatic necrosis (HP:0002605)2.46771270
35Abnormality of glycolysis (HP:0004366)2.45976736
36Increased serum pyruvate (HP:0003542)2.45976736
37Hyperglycinemia (HP:0002154)2.44931356
3811 pairs of ribs (HP:0000878)2.42979033
39Optic disc pallor (HP:0000543)2.42634935
40Patellar aplasia (HP:0006443)2.40563592
41Aplasia/Hypoplasia of the patella (HP:0006498)2.40210861
42Severe visual impairment (HP:0001141)2.40021057
43Abnormal lung lobation (HP:0002101)2.35548175
44Abnormality of the astrocytes (HP:0100707)2.34284137
45Astrocytoma (HP:0009592)2.34284137
46Abnormality of glycine metabolism (HP:0010895)2.33922738
47Abnormality of serine family amino acid metabolism (HP:0010894)2.33922738
48Hyperglycinuria (HP:0003108)2.32051876
49Abnormality of the septum pellucidum (HP:0007375)2.29776090
50Methylmalonic acidemia (HP:0002912)2.29029989
51Degeneration of anterior horn cells (HP:0002398)2.28437800
52Abnormality of the anterior horn cell (HP:0006802)2.28437800
53Neoplasm of the colon (HP:0100273)2.27147237
54Type I transferrin isoform profile (HP:0003642)2.26195967
55Increased serum lactate (HP:0002151)2.25753135
56Postnatal microcephaly (HP:0005484)2.25206792
57Exercise intolerance (HP:0003546)2.23754713
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22999248
59Abnormality of the labia minora (HP:0012880)2.22937770
60Agnosia (HP:0010524)2.22777904
61Cerebral hypomyelination (HP:0006808)2.18812769
62Abnormality of the duodenum (HP:0002246)2.18046662
63Hypothermia (HP:0002045)2.17146540
64Multiple enchondromatosis (HP:0005701)2.17114585
65Prominent metopic ridge (HP:0005487)2.15520784
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14931090
67Breast hypoplasia (HP:0003187)2.14444867
68Exertional dyspnea (HP:0002875)2.14294475
69Sloping forehead (HP:0000340)2.14160415
70Cerebral edema (HP:0002181)2.12198385
71Neoplasm of the adrenal gland (HP:0100631)2.10907973
72High anterior hairline (HP:0009890)2.10553503
733-Methylglutaconic aciduria (HP:0003535)2.08370169
74Abnormality of serum amino acid levels (HP:0003112)2.06160982
75Biliary tract neoplasm (HP:0100574)2.05348577
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04944213
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04944213
78Triphalangeal thumb (HP:0001199)2.04304680
79Microvesicular hepatic steatosis (HP:0001414)2.04262057
80Abnormality of the preputium (HP:0100587)2.03806826
81True hermaphroditism (HP:0010459)2.02955881
82Chromsome breakage (HP:0040012)1.99928084
83Colon cancer (HP:0003003)1.99576582
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98430981
85Horseshoe kidney (HP:0000085)1.98202624
86Gonadotropin excess (HP:0000837)1.97911807
87Respiratory failure (HP:0002878)1.97468427
88Diastasis recti (HP:0001540)1.95759137
89Medial flaring of the eyebrow (HP:0010747)1.93971888
90Ectopic kidney (HP:0000086)1.93489806
91Neoplasm of striated muscle (HP:0009728)1.92777960
92Absent radius (HP:0003974)1.92242208
93Proximal placement of thumb (HP:0009623)1.91803058
94Abnormality of the metopic suture (HP:0005556)1.90890461
95Leukodystrophy (HP:0002415)1.90847422
96Lissencephaly (HP:0001339)1.90706505
97Myelodysplasia (HP:0002863)1.90054533
98Pancreatic fibrosis (HP:0100732)1.89906327
99Oral leukoplakia (HP:0002745)1.89392478
100Papillary thyroid carcinoma (HP:0002895)1.89361096
101Supernumerary spleens (HP:0009799)1.88672835
102Ovarian neoplasm (HP:0100615)1.88182375
103Hypoplastic pelvis (HP:0008839)1.87998945
104Abnormal number of incisors (HP:0011064)1.87938526
105Pancreatic cysts (HP:0001737)1.87787028
106Respiratory difficulties (HP:0002880)1.87161740
107Pancreatic islet-cell hyperplasia (HP:0004510)1.86359226
108Neoplasm of the small intestine (HP:0100833)1.85271097
109Meckel diverticulum (HP:0002245)1.84408317
110Rimmed vacuoles (HP:0003805)1.82750381
111Aplasia involving forearm bones (HP:0009822)1.82291438
112Absent forearm bone (HP:0003953)1.82291438
113Depressed nasal ridge (HP:0000457)1.82178754
114Abnormal hair whorl (HP:0010721)1.82048551
115Gait imbalance (HP:0002141)1.80180914
116Thyroid carcinoma (HP:0002890)1.77665337
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.76714794
118Preaxial hand polydactyly (HP:0001177)1.76639751
119Breast carcinoma (HP:0003002)1.76420237
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76106279
121Hypoglycemic coma (HP:0001325)1.75823642
122Reduced antithrombin III activity (HP:0001976)1.75436623
123Choanal atresia (HP:0000453)1.74292423
124Abnormality of the carotid arteries (HP:0005344)1.73547059
125Abnormality of the ileum (HP:0001549)1.73262205
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72208018
127Abnormal protein N-linked glycosylation (HP:0012347)1.72208018
128Abnormal protein glycosylation (HP:0012346)1.72208018
129Abnormal glycosylation (HP:0012345)1.72208018
130Methylmalonic aciduria (HP:0012120)1.71565471
131Deviation of the thumb (HP:0009603)1.71358264
132Absent thumb (HP:0009777)1.69375693
133Sclerocornea (HP:0000647)1.68831500
134Increased intramyocellular lipid droplets (HP:0012240)1.68298048
135Anencephaly (HP:0002323)1.68124236
136Abnormal respiratory motile cilium morphology (HP:0005938)1.67070980
137Abnormal respiratory epithelium morphology (HP:0012253)1.67070980
138Carpal bone hypoplasia (HP:0001498)1.65968968
139Shoulder girdle muscle weakness (HP:0003547)1.65035094
140Neoplasm of the rectum (HP:0100743)1.64466154
141Bifid tongue (HP:0010297)1.63838116
142Embryonal neoplasm (HP:0002898)1.63431186
143Neoplasm of the adrenal cortex (HP:0100641)1.62968459
144Congenital primary aphakia (HP:0007707)1.62485706
145Short tibia (HP:0005736)1.62456747
146Median cleft lip (HP:0000161)1.62337524
147Septo-optic dysplasia (HP:0100842)1.62131527
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.61630913
149Premature graying of hair (HP:0002216)1.61294961
150Pancytopenia (HP:0001876)1.60763796
151Nephrogenic diabetes insipidus (HP:0009806)1.59131299
152Abnormality of DNA repair (HP:0003254)1.58991678
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.58828705
154Poor coordination (HP:0002370)1.58126150
155Sleep apnea (HP:0010535)1.57428134
156Glossoptosis (HP:0000162)1.57116443
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.56923599
158Aplasia/hypoplasia of the uterus (HP:0008684)1.55572238
159Rough bone trabeculation (HP:0100670)1.54677086
160Lactic acidosis (HP:0003128)1.54051966
161Hepatoblastoma (HP:0002884)1.53355215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.22766343
2SRPK13.42531649
3TRIM283.17079729
4BUB13.14625038
5MKNK13.14261688
6MKNK23.03307335
7TLK12.92711441
8EIF2AK12.91352961
9WEE12.66942498
10CDC72.66471637
11CASK2.60485957
12TAF12.42904122
13NEK12.35727410
14MARK12.33907076
15VRK12.28792184
16VRK22.26739060
17NME11.99846210
18MAP3K91.89382551
19PNCK1.87661182
20NME21.83653080
21EIF2AK31.82003932
22DYRK21.81692854
23SCYL21.76781193
24TSSK61.67662357
25NUAK11.65088463
26MAPK131.64915991
27LIMK11.63423349
28MAP3K121.60212149
29ERBB31.46083857
30PLK31.43562405
31CCNB11.37141470
32TNIK1.36406364
33CDK81.33879066
34CDK191.29319143
35TIE11.28879848
36YES11.28852208
37WNK31.26420980
38PLK41.24501291
39PBK1.23936606
40EIF2AK21.20736552
41TESK21.18281733
42DYRK31.18272979
43UHMK11.11409173
44MAP2K71.10552421
45ACVR1B1.10384435
46PLK11.08231599
47PASK1.04309624
48AURKA1.04211664
49BMPR1B1.03734278
50PIM21.03134582
51BRSK21.01994726
52ZAK1.00350578
53CSNK1G30.97920481
54PLK20.95010016
55MINK10.89252937
56ATR0.85885330
57SIK30.85502906
58AURKB0.84314204
59DYRK1A0.82012041
60CDK70.79803908
61STK38L0.79621319
62BRAF0.77838191
63ADRBK20.77671587
64RPS6KA40.77163605
65BCR0.76540277
66CHEK20.76283804
67MAP3K40.75001029
68BRSK10.74397631
69CAMK2B0.73552637
70MAP4K20.70253915
71TGFBR10.67938004
72ERBB40.65816859
73BRD40.64876734
74CSNK2A10.64465567
75IRAK20.63426242
76CSNK2A20.62774800
77BCKDK0.62000906
78CDK90.60984623
79NTRK20.60741635
80CSNK1G10.60097057
81ALK0.59935002
82CDK60.58974310
83ADRBK10.58729039
84MST40.57134509
85STK30.56862852
86GRK70.56304394
87KSR10.53982778
88CSNK1G20.52404496
89CDK140.52348000
90RPS6KA50.51537958
91TXK0.50861094
92MUSK0.50091348
93PRKCI0.49587529
94ATM0.48319725
95CLK10.47485068
96CHEK10.47212248
97CDK180.46769667
98FGFR10.46721786
99PRPF4B0.46433424
100TTK0.44901657
101CDK10.44690121
102PAK40.44622526
103NEK20.44267437
104CDK11A0.43854139
105IRAK40.43686087
106BMPR20.43241875
107CDK150.42500045
108PRKDC0.42467813
109CDK30.40359658
110CSNK1A1L0.39508017
111CDK20.39335986
112DAPK10.37439851
113FES0.37252795
114MYLK0.36016778
115STK390.35727563
116GRK10.34729440
117TESK10.34662815
118FRK0.34633610
119TAOK20.34307729
120NTRK30.33805126
121CSNK1E0.33170005
122MAPKAPK50.32886466
123NEK90.32154920
124MAP3K100.31062661
125MAP3K80.30715570
126PRKCG0.30100602
127ROCK20.29921989
128CAMK2D0.29212834
129PDK20.28064219
130CAMK2A0.27965477
131RPS6KB20.27757434
132TEC0.27326356
133AKT30.26652400
134LATS10.25919111
135RAF10.24134332

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.44674948
2Proteasome_Homo sapiens_hsa030503.89049124
3DNA replication_Homo sapiens_hsa030303.74869835
4RNA polymerase_Homo sapiens_hsa030203.46553749
5Mismatch repair_Homo sapiens_hsa034303.42834237
6Oxidative phosphorylation_Homo sapiens_hsa001903.15434531
7Spliceosome_Homo sapiens_hsa030403.03785887
8Parkinsons disease_Homo sapiens_hsa050122.92236237
9Nucleotide excision repair_Homo sapiens_hsa034202.67291475
10Homologous recombination_Homo sapiens_hsa034402.61110109
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51466359
12Huntingtons disease_Homo sapiens_hsa050162.38081896
13Protein export_Homo sapiens_hsa030602.35583140
14Pyrimidine metabolism_Homo sapiens_hsa002402.22251839
15Base excision repair_Homo sapiens_hsa034102.21397190
16Propanoate metabolism_Homo sapiens_hsa006402.07204909
17RNA transport_Homo sapiens_hsa030132.03794962
18Alzheimers disease_Homo sapiens_hsa050102.03303941
19Basal transcription factors_Homo sapiens_hsa030221.96757764
20Fanconi anemia pathway_Homo sapiens_hsa034601.91379382
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82221438
22Cell cycle_Homo sapiens_hsa041101.80310212
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.72100005
24Non-homologous end-joining_Homo sapiens_hsa034501.71964038
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70434691
26RNA degradation_Homo sapiens_hsa030181.65205517
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56837445
28Fatty acid elongation_Homo sapiens_hsa000621.56535263
29Selenocompound metabolism_Homo sapiens_hsa004501.53860011
30Pyruvate metabolism_Homo sapiens_hsa006201.44686353
31mRNA surveillance pathway_Homo sapiens_hsa030151.40410092
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38635357
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37401563
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32332449
35Purine metabolism_Homo sapiens_hsa002301.29580461
36Nicotine addiction_Homo sapiens_hsa050331.28411942
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26591015
38Vitamin B6 metabolism_Homo sapiens_hsa007501.26577107
39One carbon pool by folate_Homo sapiens_hsa006701.20776204
40Biosynthesis of amino acids_Homo sapiens_hsa012301.14515042
41Carbon metabolism_Homo sapiens_hsa012001.12408286
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10270799
43Phototransduction_Homo sapiens_hsa047441.09662664
44Cardiac muscle contraction_Homo sapiens_hsa042601.02537425
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94790380
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93766047
47Epstein-Barr virus infection_Homo sapiens_hsa051690.87905563
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87150428
49Folate biosynthesis_Homo sapiens_hsa007900.85902271
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84569767
51Alcoholism_Homo sapiens_hsa050340.82344286
52Oocyte meiosis_Homo sapiens_hsa041140.80487655
53Systemic lupus erythematosus_Homo sapiens_hsa053220.77818445
54p53 signaling pathway_Homo sapiens_hsa041150.77655928
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75173604
56Fatty acid metabolism_Homo sapiens_hsa012120.72651871
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72013108
58Serotonergic synapse_Homo sapiens_hsa047260.71332405
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69485312
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68745247
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68607778
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66749662
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65166406
64N-Glycan biosynthesis_Homo sapiens_hsa005100.63935016
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63842931
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63707633
67Butanoate metabolism_Homo sapiens_hsa006500.63127814
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62790361
69Sulfur metabolism_Homo sapiens_hsa009200.62187311
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58977082
71Collecting duct acid secretion_Homo sapiens_hsa049660.58935082
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56460089
73Vibrio cholerae infection_Homo sapiens_hsa051100.56317971
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52663821
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50322050
76Long-term depression_Homo sapiens_hsa047300.49723815
77Taste transduction_Homo sapiens_hsa047420.49630752
78Arginine and proline metabolism_Homo sapiens_hsa003300.49561756
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48905928
80TGF-beta signaling pathway_Homo sapiens_hsa043500.47929830
81Dopaminergic synapse_Homo sapiens_hsa047280.43581586
82Peroxisome_Homo sapiens_hsa041460.42562185
83Axon guidance_Homo sapiens_hsa043600.42013433
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41483510
85Fatty acid degradation_Homo sapiens_hsa000710.41092777
86beta-Alanine metabolism_Homo sapiens_hsa004100.40377231
87Autoimmune thyroid disease_Homo sapiens_hsa053200.39995219
88Wnt signaling pathway_Homo sapiens_hsa043100.39606119
89Arachidonic acid metabolism_Homo sapiens_hsa005900.38335058
90Synaptic vesicle cycle_Homo sapiens_hsa047210.37391677
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36052410
92Ether lipid metabolism_Homo sapiens_hsa005650.35892817
93Pentose phosphate pathway_Homo sapiens_hsa000300.35395066
94Hippo signaling pathway_Homo sapiens_hsa043900.35124703
95Metabolic pathways_Homo sapiens_hsa011000.33820998
96Primary immunodeficiency_Homo sapiens_hsa053400.32041005
97Viral carcinogenesis_Homo sapiens_hsa052030.31207595
98Basal cell carcinoma_Homo sapiens_hsa052170.31001853
99Lysine degradation_Homo sapiens_hsa003100.30335171
100Amphetamine addiction_Homo sapiens_hsa050310.30137824
101Allograft rejection_Homo sapiens_hsa053300.29173381
102Colorectal cancer_Homo sapiens_hsa052100.29082071
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28985145
104Herpes simplex infection_Homo sapiens_hsa051680.27844718
105Hedgehog signaling pathway_Homo sapiens_hsa043400.27409350
106Asthma_Homo sapiens_hsa053100.26578749
107Sphingolipid metabolism_Homo sapiens_hsa006000.26517717
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26052099
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25906959
110Morphine addiction_Homo sapiens_hsa050320.25637808
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25502131
112Cocaine addiction_Homo sapiens_hsa050300.25477299
113GABAergic synapse_Homo sapiens_hsa047270.25025633
114HTLV-I infection_Homo sapiens_hsa051660.24818377
115Phagosome_Homo sapiens_hsa041450.24548334
116Gap junction_Homo sapiens_hsa045400.24192547
117Long-term potentiation_Homo sapiens_hsa047200.23806035
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.23617751
119Type I diabetes mellitus_Homo sapiens_hsa049400.21534612
120Regulation of autophagy_Homo sapiens_hsa041400.20298650
121Thyroid cancer_Homo sapiens_hsa052160.19941560
122Glutamatergic synapse_Homo sapiens_hsa047240.19749895
123Antigen processing and presentation_Homo sapiens_hsa046120.19051562
124Adherens junction_Homo sapiens_hsa045200.18718891
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18679813
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.18527848
127Melanogenesis_Homo sapiens_hsa049160.17868511
128Sulfur relay system_Homo sapiens_hsa041220.16161064
129Glutathione metabolism_Homo sapiens_hsa004800.15782872
130Graft-versus-host disease_Homo sapiens_hsa053320.15560687
131Cholinergic synapse_Homo sapiens_hsa047250.15263779
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15159279
133Tryptophan metabolism_Homo sapiens_hsa003800.15029601
134Tight junction_Homo sapiens_hsa045300.14878484
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14661672
136Caffeine metabolism_Homo sapiens_hsa002320.13377443
137Circadian rhythm_Homo sapiens_hsa047100.13107365
138Steroid biosynthesis_Homo sapiens_hsa001000.12523285
139Olfactory transduction_Homo sapiens_hsa047400.12252150
140Circadian entrainment_Homo sapiens_hsa047130.11845888
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11545141
142Melanoma_Homo sapiens_hsa052180.11063947
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.08418185
144Nitrogen metabolism_Homo sapiens_hsa009100.05198793
145MicroRNAs in cancer_Homo sapiens_hsa052060.03924693
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03400112

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