TSNARE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.50703619
2positive regulation of gamma-delta T cell activation (GO:0046645)4.76494572
3mannose metabolic process (GO:0006013)4.50543452
4response to muramyl dipeptide (GO:0032495)4.39551617
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.12053097
6negative regulation of cell killing (GO:0031342)4.12053097
7regulation of gamma-delta T cell activation (GO:0046643)4.05059652
8histone H3-K36 demethylation (GO:0070544)3.93115193
9regulation of gamma-delta T cell differentiation (GO:0045586)3.83235567
10positive thymic T cell selection (GO:0045059)3.78302854
11thymic T cell selection (GO:0045061)3.74826885
12response to peptidoglycan (GO:0032494)3.70402291
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62142241
14antigen processing and presentation of endogenous antigen (GO:0019883)3.52404953
15tolerance induction (GO:0002507)3.43909350
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37913538
17T cell selection (GO:0045058)3.31451478
18epithelial cell differentiation involved in prostate gland development (GO:0060742)3.30232012
19germinal center formation (GO:0002467)3.27628202
20negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.26728886
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26201211
22detection of bacterium (GO:0016045)3.25120801
23negative thymic T cell selection (GO:0045060)3.24351649
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22767695
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.22767695
26modulation by symbiont of host immune response (GO:0052553)3.22767695
27positive regulation by symbiont of host defense response (GO:0052509)3.22767695
28modulation by symbiont of host defense response (GO:0052031)3.22767695
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22767695
30NIK/NF-kappaB signaling (GO:0038061)3.21655693
31signal complex assembly (GO:0007172)3.19227723
32detection of other organism (GO:0098543)3.16083137
33histone H4 deacetylation (GO:0070933)3.15557657
34negative regulation of myotube differentiation (GO:0010832)3.10635926
35histone H3 deacetylation (GO:0070932)3.09974480
36apoptotic process involved in morphogenesis (GO:0060561)3.07623555
37regulation of ARF protein signal transduction (GO:0032012)3.04634663
38positive regulation of B cell differentiation (GO:0045579)2.99981508
39negative T cell selection (GO:0043383)2.99421109
40B cell receptor signaling pathway (GO:0050853)2.99360022
41positive T cell selection (GO:0043368)2.99113908
423-UTR-mediated mRNA stabilization (GO:0070935)2.98321294
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.96194483
44regulation of ARF GTPase activity (GO:0032312)2.95444303
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95276901
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90058968
47macrophage activation involved in immune response (GO:0002281)2.89707863
48activation of Rac GTPase activity (GO:0032863)2.87447616
49histone H3-K9 demethylation (GO:0033169)2.84740571
50histone lysine demethylation (GO:0070076)2.80854053
51Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77882003
52positive regulation of Cdc42 GTPase activity (GO:0043089)2.77291489
53regulation of leukocyte degranulation (GO:0043300)2.72897018
54negative regulation of cell size (GO:0045792)2.71937797
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71517500
56leukocyte aggregation (GO:0070486)2.71482658
57regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70919105
58negative regulation of toll-like receptor signaling pathway (GO:0034122)2.70057665
59embryonic process involved in female pregnancy (GO:0060136)2.69071593
60activation of JUN kinase activity (GO:0007257)2.67174998
61regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66035356
62negative regulation of interleukin-12 production (GO:0032695)2.65232642
63regulation of B cell receptor signaling pathway (GO:0050855)2.64877980
64immunoglobulin mediated immune response (GO:0016064)2.64613072
65histone demethylation (GO:0016577)2.62670846
66negative regulation of leukocyte mediated immunity (GO:0002704)2.62638516
67modulation by virus of host process (GO:0019054)2.62552242
68modulation by symbiont of host cellular process (GO:0044068)2.61491966
69cell-cell junction maintenance (GO:0045217)2.60978492
70T cell migration (GO:0072678)2.58034974
71regulation of T-helper 2 cell differentiation (GO:0045628)2.55470369
72response to laminar fluid shear stress (GO:0034616)2.55193506
73mucosal-associated lymphoid tissue development (GO:0048537)2.54673376
74Peyers patch development (GO:0048541)2.54673376
75barbed-end actin filament capping (GO:0051016)2.54637454
76regulation of mast cell degranulation (GO:0043304)2.51815348
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50591192
78detection of external biotic stimulus (GO:0098581)2.50294036
79negative regulation of lymphocyte mediated immunity (GO:0002707)2.49694655
80lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48702492
81pinocytosis (GO:0006907)2.48218334
82positive regulation of Rap GTPase activity (GO:0032854)2.47862439
83negative regulation of innate immune response (GO:0045824)2.47042402
84activation of MAPKKK activity (GO:0000185)2.45419737
85response to type I interferon (GO:0034340)2.43903771
86mature B cell differentiation involved in immune response (GO:0002313)2.43486152
87retrograde transport, endosome to Golgi (GO:0042147)2.42810404
88negative regulation of T cell mediated immunity (GO:0002710)2.42415668
89regulation of NFAT protein import into nucleus (GO:0051532)2.42205848
90neutrophil activation involved in immune response (GO:0002283)2.42147731
91type I interferon signaling pathway (GO:0060337)2.41180629
92cellular response to type I interferon (GO:0071357)2.41180629
93regulation of necroptotic process (GO:0060544)2.39418447
94negative regulation of myeloid cell apoptotic process (GO:0033033)2.38762333
95protein dealkylation (GO:0008214)2.38672838
96protein demethylation (GO:0006482)2.38672838
97intracellular estrogen receptor signaling pathway (GO:0030520)2.38064367
98stress fiber assembly (GO:0043149)2.37882998
99endothelial cell chemotaxis (GO:0035767)2.37418980
100regulation of interleukin-2 biosynthetic process (GO:0045076)2.36499502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.53746840
2* MYC_22102868_ChIP-Seq_BL_Human3.12143184
3* LXR_22292898_ChIP-Seq_THP-1_Human2.99292083
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.98082454
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79636707
6KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.68588157
7KDM2B_26808549_Chip-Seq_DND41_Human2.52013193
8TCF7_22412390_ChIP-Seq_EML_Mouse2.47919934
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.34762581
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25591821
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19171845
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19168010
13VDR_24763502_ChIP-Seq_THP-1_Human2.15449755
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06271748
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02945701
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01385856
17MAF_26560356_Chip-Seq_TH1_Human1.98943176
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98000484
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97382204
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.96869184
21* RACK7_27058665_Chip-Seq_MCF-7_Human1.96091751
22KDM2B_26808549_Chip-Seq_K562_Human1.86818664
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84573127
24KDM2B_26808549_Chip-Seq_JURKAT_Human1.83586467
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83259024
26UTX_26944678_Chip-Seq_JUKART_Human1.83130692
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.78860890
28* P68_20966046_ChIP-Seq_HELA_Human1.78074880
29MAF_26560356_Chip-Seq_TH2_Human1.76860098
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76557713
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71085409
32* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64476297
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.64391562
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.64238488
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.59942833
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59490566
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58079428
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56872964
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55515104
40GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54796689
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54335833
42* SMC4_20622854_ChIP-Seq_HELA_Human1.53504434
43* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49907032
44SCL_19346495_ChIP-Seq_HPC-7_Human1.49823072
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.46430068
46CREB1_26743006_Chip-Seq_LNCaP_Human1.45210854
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.45129404
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.44732484
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44649760
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.44300188
51* BCOR_27268052_Chip-Seq_Bcells_Human1.43323807
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40983636
53* BCL6_27268052_Chip-Seq_Bcells_Human1.38479642
54SPI1_23127762_ChIP-Seq_K562_Human1.37929013
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.36367716
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34062435
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.33500640
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33282231
59* DROSHA_22980978_ChIP-Seq_HELA_Human1.33273926
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32978942
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32642296
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32234828
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30665966
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30450510
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29722877
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29384194
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26644011
68NCOR1_26117541_ChIP-Seq_K562_Human1.25081305
69CTCF_27219007_Chip-Seq_Bcells_Human1.18119820
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18093645
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18049338
72* RUNX1_27514584_Chip-Seq_MCF-7_Human1.16109607
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15855468
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15457638
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14620798
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14617188
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14195159
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13825205
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13789671
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13587534
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.12342570
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09818911
83* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09397056
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09324459
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09052909
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.06617491
87ZNF263_19887448_ChIP-Seq_K562_Human1.06133677
88RUNX_20019798_ChIP-Seq_JUKART_Human1.05565672
89SA1_27219007_Chip-Seq_Bcells_Human1.04916936
90* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04877824
91MYB_26560356_Chip-Seq_TH1_Human1.04384028
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04264980
93TP63_22573176_ChIP-Seq_HFKS_Human1.04252473
94PHF8_20622854_ChIP-Seq_HELA_Human1.03916766
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03540360
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03536256
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03258503
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02429980
99CIITA_25753668_ChIP-Seq_RAJI_Human1.00813703
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00002264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.81709438
2MP0003303_peritoneal_inflammation3.36216192
3MP0009278_abnormal_bone_marrow3.35536650
4MP0005451_abnormal_body_composition3.20710387
5MP0005058_abnormal_lysosome_morphology3.14754161
6MP0003172_abnormal_lysosome_physiology2.85029530
7MP0005076_abnormal_cell_differentiation2.66627628
8MP0004947_skin_inflammation2.49767741
9MP0008260_abnormal_autophagy2.45294117
10MP0003763_abnormal_thymus_physiology2.41109442
11MP0004510_myositis2.34601386
12MP0001835_abnormal_antigen_presentation2.16014123
13MP0005000_abnormal_immune_tolerance2.14637970
14MP0002419_abnormal_innate_immunity2.09702244
15MP0001790_abnormal_immune_system2.09590214
16MP0005387_immune_system_phenotype2.09590214
17MP0000685_abnormal_immune_system2.08831514
18MP0005025_abnormal_response_to2.08688505
19MP0001800_abnormal_humoral_immune2.06541450
20MP0003705_abnormal_hypodermis_morpholog1.96013398
21MP0009840_abnormal_foam_cell1.93859573
22MP0005671_abnormal_response_to1.92818733
23MP0002723_abnormal_immune_serum1.85330891
24MP0002420_abnormal_adaptive_immunity1.84235634
25MP0001819_abnormal_immune_cell1.83274558
26MP0003191_abnormal_cellular_cholesterol1.82672621
27MP0002452_abnormal_antigen_presenting1.81869853
28MP0003300_gastrointestinal_ulcer1.77422112
29MP0003453_abnormal_keratinocyte_physiol1.76670685
30MP0009333_abnormal_splenocyte_physiolog1.72618322
31MP0004858_abnormal_nervous_system1.71899196
32MP0010155_abnormal_intestine_physiology1.67305385
33MP0001545_abnormal_hematopoietic_system1.63048791
34MP0005397_hematopoietic_system_phenotyp1.63048791
35MP0003724_increased_susceptibility_to1.58892312
36MP0002822_catalepsy1.56616804
37MP0001849_ear_inflammation1.55471881
38MP0001533_abnormal_skeleton_physiology1.53066770
39MP0000716_abnormal_immune_system1.51367369
40MP0002398_abnormal_bone_marrow1.50719152
41MP0002405_respiratory_system_inflammati1.46075144
42MP0002998_abnormal_bone_remodeling1.45212431
43MP0002009_preneoplasia1.42807475
44MP0002148_abnormal_hypersensitivity_rea1.42602018
45MP0002653_abnormal_ependyma_morphology1.41417115
46MP0005464_abnormal_platelet_physiology1.41098590
47MP0000703_abnormal_thymus_morphology1.38224683
48MP0002933_joint_inflammation1.37716577
49MP0002722_abnormal_immune_system1.33776293
50MP0006082_CNS_inflammation1.32652734
51MP0001873_stomach_inflammation1.29633724
52MP0005310_abnormal_salivary_gland1.28843080
53MP0004381_abnormal_hair_follicle1.28269345
54MP0003329_amyloid_beta_deposits1.23093196
55MP0000689_abnormal_spleen_morphology1.22801735
56MP0003866_abnormal_defecation1.21564281
57MP0002429_abnormal_blood_cell1.21082328
58MP0002796_impaired_skin_barrier1.21067759
59MP0009785_altered_susceptibility_to1.20744428
60MP0003690_abnormal_glial_cell1.20620517
61MP0000858_altered_metastatic_potential1.20355643
62MP0003183_abnormal_peptide_metabolism1.19159986
63MP0001845_abnormal_inflammatory_respons1.18310214
64MP0005666_abnormal_adipose_tissue1.18087531
65MP0001851_eye_inflammation1.14872407
66MP0002396_abnormal_hematopoietic_system1.10638003
67MP0000604_amyloidosis1.09700148
68MP0003091_abnormal_cell_migration1.09211868
69MP0000465_gastrointestinal_hemorrhage1.07914278
70MP0001853_heart_inflammation1.06813885
71MP0000678_abnormal_parathyroid_gland1.06374133
72MP0004185_abnormal_adipocyte_glucose1.03765302
73MP0003075_altered_response_to0.98700963
74MP0000490_abnormal_crypts_of0.97738159
75MP0004808_abnormal_hematopoietic_stem0.96760431
76MP0002249_abnormal_larynx_morphology0.89529750
77MP0005375_adipose_tissue_phenotype0.88691816
78MP0010234_abnormal_vibrissa_follicle0.88547355
79MP0005409_darkened_coat_color0.85668198
80MP0003878_abnormal_ear_physiology0.85097793
81MP0005377_hearing/vestibular/ear_phenot0.85097793
82MP0002166_altered_tumor_susceptibility0.84385644
83MP0004859_abnormal_synaptic_plasticity0.83700346
84MP0008469_abnormal_protein_level0.83398967
85MP0002254_reproductive_system_inflammat0.83310255
86MP0008961_abnormal_basal_metabolism0.82582834
87MP0003828_pulmonary_edema0.81985493
88MP0000751_myopathy0.81562611
89MP0003566_abnormal_cell_adhesion0.79438177
90MP0009764_decreased_sensitivity_to0.76210733
91MP0004130_abnormal_muscle_cell0.75563529
92MP0002332_abnormal_exercise_endurance0.73927213
93MP0002089_abnormal_postnatal_growth/wei0.73882697
94MP0005621_abnormal_cell_physiology0.72565284
95MP0001348_abnormal_lacrimal_gland0.72437263
96MP0003879_abnormal_hair_cell0.71362147
97MP0000681_abnormal_thyroid_gland0.71165172
98MP0005390_skeleton_phenotype0.69874060
99MP0003045_fibrosis0.67689252
100MP0001663_abnormal_digestive_system0.67649946

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.33525521
2Colitis (HP:0002583)3.84194379
3Abnormality of the fingertips (HP:0001211)3.42690186
4Broad face (HP:0000283)3.41824284
5Obstructive sleep apnea (HP:0002870)3.31256095
6Gastrointestinal inflammation (HP:0004386)3.20957755
7Increased IgE level (HP:0003212)3.07739238
8Recurrent abscess formation (HP:0002722)2.98877826
9Mediastinal lymphadenopathy (HP:0100721)2.98016921
10Recurrent bacterial skin infections (HP:0005406)2.96391827
11Inflammation of the large intestine (HP:0002037)2.93707567
12Hyperacusis (HP:0010780)2.92655788
13Myositis (HP:0100614)2.92357687
14Cellulitis (HP:0100658)2.91411737
15Abnormality of macrophages (HP:0004311)2.89555085
16Loss of speech (HP:0002371)2.83617633
17Increased cerebral lipofuscin (HP:0011813)2.79219267
18Dysostosis multiplex (HP:0000943)2.78931247
19Thoracic kyphosis (HP:0002942)2.71342681
20Neuronal loss in central nervous system (HP:0002529)2.66721410
21Cerebral aneurysm (HP:0004944)2.65576413
22Interstitial pulmonary disease (HP:0006530)2.54681566
23Pustule (HP:0200039)2.49991153
24Gingivitis (HP:0000230)2.49014137
25Obstructive lung disease (HP:0006536)2.38276143
26Chronic obstructive pulmonary disease (HP:0006510)2.38276143
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37236873
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36556973
29Flat acetabular roof (HP:0003180)2.36172379
30Abnormality of the thoracic spine (HP:0100711)2.33787823
31Distal lower limb amyotrophy (HP:0008944)2.31132270
32Thin bony cortex (HP:0002753)2.31014170
33Recurrent gram-negative bacterial infections (HP:0005420)2.30960317
34Increased neuronal autofluorescent lipopigment (HP:0002074)2.29286063
35Elevated erythrocyte sedimentation rate (HP:0003565)2.27092329
36Recurrent viral infections (HP:0004429)2.23974358
37Meningitis (HP:0001287)2.22978666
38Metaphyseal cupping (HP:0003021)2.21988506
39Recurrent fungal infections (HP:0002841)2.20940738
40Mucopolysacchariduria (HP:0008155)2.19103408
41Urinary glycosaminoglycan excretion (HP:0003541)2.19103408
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.16018617
43Abnormality of the columella (HP:0009929)2.14661644
44Supranuclear gaze palsy (HP:0000605)2.14531541
45Abnormality of glycolipid metabolism (HP:0010969)2.14005762
46Abnormality of liposaccharide metabolism (HP:0010968)2.14005762
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.14005762
48Abnormality of polysaccharide metabolism (HP:0011012)2.11614291
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11614291
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11614291
51Gastrointestinal stroma tumor (HP:0100723)2.08174260
52Annular pancreas (HP:0001734)2.06744108
53Slow saccadic eye movements (HP:0000514)2.06627420
54Agammaglobulinemia (HP:0004432)2.04229068
55Orchitis (HP:0100796)2.02554145
56Nasal polyposis (HP:0100582)2.01054550
57Hemorrhage of the eye (HP:0011885)1.94154519
58Emphysema (HP:0002097)1.93503914
59Abnormality of the nasal mucosa (HP:0000433)1.92920805
60Asymmetric septal hypertrophy (HP:0001670)1.91008725
61Neurofibrillary tangles (HP:0002185)1.90238128
62Recurrent skin infections (HP:0001581)1.88820019
63J-shaped sella turcica (HP:0002680)1.88690643
64Polygenic inheritance (HP:0010982)1.87152476
65Papilledema (HP:0001085)1.85938714
66Exercise-induced myalgia (HP:0003738)1.84105403
67Panhypogammaglobulinemia (HP:0003139)1.82177707
68Increased connective tissue (HP:0009025)1.80871007
69Peripheral hypomyelination (HP:0007182)1.79802919
70Axonal loss (HP:0003447)1.78909385
71Cervical subluxation (HP:0003308)1.78596177
72Difficulty climbing stairs (HP:0003551)1.78094403
73Spontaneous hematomas (HP:0007420)1.77791177
74Lymphopenia (HP:0001888)1.74082732
75Upper limb amyotrophy (HP:0009129)1.74026619
76Distal upper limb amyotrophy (HP:0007149)1.74026619
77Pointed chin (HP:0000307)1.73895572
78Distal lower limb muscle weakness (HP:0009053)1.73264351
79Bowel incontinence (HP:0002607)1.72832962
80Restrictive lung disease (HP:0002091)1.72434189
81Vasculitis (HP:0002633)1.71849611
82Easy fatigability (HP:0003388)1.71500041
83Segmental peripheral demyelination/remyelination (HP:0003481)1.71471384
84Ankle clonus (HP:0011448)1.71250701
85Hypertriglyceridemia (HP:0002155)1.70976446
86Optic neuritis (HP:0100653)1.70757390
87Retrobulbar optic neuritis (HP:0100654)1.70757390
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.70735293
89Recurrent sinusitis (HP:0011108)1.70471482
90Amyloidosis (HP:0011034)1.70375808
91Stomatitis (HP:0010280)1.69382066
92Cerebral inclusion bodies (HP:0100314)1.69258705
93Broad distal phalanx of finger (HP:0009836)1.69054403
94Nuclear cataract (HP:0100018)1.69046302
95Recurrent cutaneous fungal infections (HP:0011370)1.69018612
96Chronic mucocutaneous candidiasis (HP:0002728)1.69018612
97Myopathic facies (HP:0002058)1.68834196
98Stridor (HP:0010307)1.66045729
99Sepsis (HP:0100806)1.65517976
100Growth hormone excess (HP:0000845)1.65153123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.73931743
2TRIB33.64220650
3MAP4K12.97583367
4ERN12.65866289
5SIK12.41941416
6RIPK42.37511115
7ICK2.29927326
8SMG12.23009326
9IRAK32.06580461
10EEF2K2.04553483
11TNK21.99429134
12MARK21.89356674
13EPHB11.88766463
14SIK21.84055972
15MAP2K31.72432467
16MAPK151.71950263
17TESK21.66508599
18TBK11.61690945
19TAOK11.54537975
20BLK1.53389130
21MAP3K101.53338192
22CDK121.52273585
23MAP3K141.47570227
24MAP3K131.39580625
25RIPK11.36790098
26TYK21.31568230
27PRKD21.28624102
28IRAK21.28395906
29TAOK21.27831586
30CDC42BPA1.26889547
31PKN21.24645684
32MAP3K111.24203591
33FGFR41.22997467
34MAP3K71.22316423
35SIK31.20762401
36NME21.20183732
37ZAP701.15774369
38FES1.15255203
39BTK1.15193915
40IRAK41.13897715
41CSK1.13647190
42DYRK1B1.13025352
43CAMKK11.07017996
44GRK61.03644877
45CSF1R1.02544989
46TTN1.01848430
47MAP3K61.01132138
48MAP3K31.01128879
49MAP3K10.93230409
50IKBKE0.92692201
51MAP2K20.90489086
52DDR20.88039067
53MAPK120.85294371
54FGR0.84777270
55HCK0.82830766
56RPS6KA20.82812430
57HIPK20.82302909
58RPS6KL10.82195122
59RPS6KC10.82195122
60BMX0.82021151
61MATK0.81974098
62MTOR0.80767557
63JAK30.76678930
64CDK40.73662740
65TESK10.71719336
66CAMK1D0.71133112
67SYK0.68549044
68MAPK110.67979278
69CAMK40.67814072
70PTK60.65213891
71PRKD30.65209821
72PDPK10.64925617
73PDK10.63985854
74RPS6KA60.63948368
75JAK10.63445708
76IKBKB0.62435370
77EPHA20.60034422
78CDK60.56062719
79CHUK0.53796056
80LCK0.53425309
81ITK0.53375162
82JAK20.51345350
83KIT0.50439414
84TYRO30.50273909
85MAP2K60.49824316
86BRAF0.49523782
87MAPK40.49404366
88MAPK70.49059365
89KSR20.45877119
90RET0.45437651
91LYN0.45109819
92ARAF0.44979918
93LRRK20.40072644
94PASK0.39292000
95RPS6KA10.39082622
96FYN0.38850868
97PAK40.37892974
98UHMK10.36679035
99MAPKAPK20.36393979
100PDGFRA0.34826886

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.26475345
2Acute myeloid leukemia_Homo sapiens_hsa052212.25940790
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12195158
4Osteoclast differentiation_Homo sapiens_hsa043802.06950836
5B cell receptor signaling pathway_Homo sapiens_hsa046622.03959359
6Notch signaling pathway_Homo sapiens_hsa043301.93696126
7Leishmaniasis_Homo sapiens_hsa051401.82323752
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77052691
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.75141859
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66201927
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61377751
12VEGF signaling pathway_Homo sapiens_hsa043701.59273949
13Chronic myeloid leukemia_Homo sapiens_hsa052201.56763234
14Non-small cell lung cancer_Homo sapiens_hsa052231.45627066
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.39841163
16Neurotrophin signaling pathway_Homo sapiens_hsa047221.38072611
17Tuberculosis_Homo sapiens_hsa051521.34689602
18T cell receptor signaling pathway_Homo sapiens_hsa046601.31403850
19Staphylococcus aureus infection_Homo sapiens_hsa051501.30865762
20Graft-versus-host disease_Homo sapiens_hsa053321.30521108
21Allograft rejection_Homo sapiens_hsa053301.29991461
22GnRH signaling pathway_Homo sapiens_hsa049121.28398097
23Primary immunodeficiency_Homo sapiens_hsa053401.26760121
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24844412
25Toxoplasmosis_Homo sapiens_hsa051451.20483085
26TNF signaling pathway_Homo sapiens_hsa046681.19821055
27Autoimmune thyroid disease_Homo sapiens_hsa053201.16526201
28Lysosome_Homo sapiens_hsa041421.15596830
29Pancreatic cancer_Homo sapiens_hsa052121.14256649
30Influenza A_Homo sapiens_hsa051641.13328933
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.10335052
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09353249
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.08102229
34Hepatitis B_Homo sapiens_hsa051611.06526422
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06520807
36mTOR signaling pathway_Homo sapiens_hsa041501.06271109
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05689324
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05521534
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04814821
40Hepatitis C_Homo sapiens_hsa051601.02277162
41Viral myocarditis_Homo sapiens_hsa054161.01485512
42Herpes simplex infection_Homo sapiens_hsa051681.01171423
43ErbB signaling pathway_Homo sapiens_hsa040121.00293664
44Choline metabolism in cancer_Homo sapiens_hsa052311.00190826
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99716397
46Fructose and mannose metabolism_Homo sapiens_hsa000510.98793274
47Prolactin signaling pathway_Homo sapiens_hsa049170.98002005
48Endometrial cancer_Homo sapiens_hsa052130.97949574
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.96122046
50Insulin signaling pathway_Homo sapiens_hsa049100.95911583
51Chemokine signaling pathway_Homo sapiens_hsa040620.95489777
52Salmonella infection_Homo sapiens_hsa051320.91840269
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90849514
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.89357058
55Bladder cancer_Homo sapiens_hsa052190.88745543
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.88161463
57Renal cell carcinoma_Homo sapiens_hsa052110.87344175
58Pertussis_Homo sapiens_hsa051330.85334828
59Insulin resistance_Homo sapiens_hsa049310.85329364
60Apoptosis_Homo sapiens_hsa042100.85039792
61Inositol phosphate metabolism_Homo sapiens_hsa005620.84736697
62Viral carcinogenesis_Homo sapiens_hsa052030.84291523
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83550442
64Shigellosis_Homo sapiens_hsa051310.82959719
65HTLV-I infection_Homo sapiens_hsa051660.82821714
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77828922
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77333721
68Estrogen signaling pathway_Homo sapiens_hsa049150.77307527
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76041747
70Type I diabetes mellitus_Homo sapiens_hsa049400.75929992
71Glioma_Homo sapiens_hsa052140.75638664
72Type II diabetes mellitus_Homo sapiens_hsa049300.75418225
73Asthma_Homo sapiens_hsa053100.75397304
74Measles_Homo sapiens_hsa051620.75166572
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.74980903
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74351113
77Colorectal cancer_Homo sapiens_hsa052100.72540983
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70892921
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.69076992
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.68918619
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68368157
82Endocytosis_Homo sapiens_hsa041440.67300374
83Long-term potentiation_Homo sapiens_hsa047200.66881190
84Epstein-Barr virus infection_Homo sapiens_hsa051690.66728942
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66323469
86Malaria_Homo sapiens_hsa051440.65783693
87Prion diseases_Homo sapiens_hsa050200.65584416
88Galactose metabolism_Homo sapiens_hsa000520.65244855
89Platelet activation_Homo sapiens_hsa046110.65241597
90Antigen processing and presentation_Homo sapiens_hsa046120.65139156
91Hematopoietic cell lineage_Homo sapiens_hsa046400.64759547
92Lysine degradation_Homo sapiens_hsa003100.64108543
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.63926568
94Pentose phosphate pathway_Homo sapiens_hsa000300.62778027
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62621676
96AMPK signaling pathway_Homo sapiens_hsa041520.62055723
97Phagosome_Homo sapiens_hsa041450.60967474
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58682190
99MAPK signaling pathway_Homo sapiens_hsa040100.58048453
100Amoebiasis_Homo sapiens_hsa051460.54874026

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