TSNAX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86176588
2synaptic vesicle maturation (GO:0016188)5.81924386
3synaptic vesicle exocytosis (GO:0016079)5.53606970
4proteasome assembly (GO:0043248)5.50934919
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.41984077
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39904994
7regulation of synaptic vesicle exocytosis (GO:2000300)5.10728299
8glutamate secretion (GO:0014047)5.08797958
9locomotory exploration behavior (GO:0035641)5.04989411
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02716180
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63227601
12regulation of synaptic vesicle transport (GO:1902803)4.62124819
13vocalization behavior (GO:0071625)4.53916187
14regulation of synapse structural plasticity (GO:0051823)4.50967959
15regulation of glutamate receptor signaling pathway (GO:1900449)4.48052204
16DNA strand renaturation (GO:0000733)4.45282497
17layer formation in cerebral cortex (GO:0021819)4.35095070
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.33455442
19protein localization to synapse (GO:0035418)4.29988039
20cullin deneddylation (GO:0010388)4.23286284
21neurotransmitter secretion (GO:0007269)4.22827727
22neuronal action potential propagation (GO:0019227)4.21415460
23rRNA methylation (GO:0031167)4.21322593
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17598116
25activation of protein kinase A activity (GO:0034199)4.13121412
26rRNA modification (GO:0000154)4.12702212
27regulation of neuronal synaptic plasticity (GO:0048168)4.09318790
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04924103
29respiratory chain complex IV assembly (GO:0008535)4.02197539
30exploration behavior (GO:0035640)3.95406709
31cellular potassium ion homeostasis (GO:0030007)3.88779867
32positive regulation of synapse maturation (GO:0090129)3.85622489
33protein deneddylation (GO:0000338)3.77238977
34sodium ion export (GO:0071436)3.76617478
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.74056618
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73448815
37water-soluble vitamin biosynthetic process (GO:0042364)3.71983903
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.63767249
39regulation of meiosis I (GO:0060631)3.63200643
40cell communication by electrical coupling (GO:0010644)3.61967882
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61606553
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.60958649
43platelet dense granule organization (GO:0060155)3.54477065
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52703592
45ATP synthesis coupled proton transport (GO:0015986)3.52703592
46antigen processing and presentation via MHC class Ib (GO:0002475)3.48608585
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47563821
48peptidyl-histidine modification (GO:0018202)3.45719891
49cytochrome complex assembly (GO:0017004)3.45213210
50CENP-A containing nucleosome assembly (GO:0034080)3.42749028
51chromatin remodeling at centromere (GO:0031055)3.42296720
52glutamate receptor signaling pathway (GO:0007215)3.41130642
53synaptic transmission, glutamatergic (GO:0035249)3.40886489
54negative regulation of microtubule polymerization (GO:0031115)3.40316315
55long-term memory (GO:0007616)3.39520999
56positive regulation of membrane potential (GO:0045838)3.39268762
57signal peptide processing (GO:0006465)3.39061797
58regulation of dendritic spine morphogenesis (GO:0061001)3.39029909
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38939490
60neuron-neuron synaptic transmission (GO:0007270)3.37567402
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.37138344
62dendritic spine morphogenesis (GO:0060997)3.37025308
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33796270
64regulation of synaptic plasticity (GO:0048167)3.33325116
65neurotransmitter-gated ion channel clustering (GO:0072578)3.32693745
66DNA double-strand break processing (GO:0000729)3.28514637
67neuromuscular process controlling balance (GO:0050885)3.25197303
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25131602
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23727197
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.23291005
71DNA deamination (GO:0045006)3.23079789
72response to pheromone (GO:0019236)3.22693399
73regulation of postsynaptic membrane potential (GO:0060078)3.22657924
74neurotransmitter transport (GO:0006836)3.22323418
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21587071
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21223895
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19569881
78positive regulation of neurotransmitter transport (GO:0051590)3.19124319
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19038678
80protein K6-linked ubiquitination (GO:0085020)3.17934511
81mitochondrial respiratory chain complex assembly (GO:0033108)3.16949015
82neuron cell-cell adhesion (GO:0007158)3.16512306
83vesicle transport along microtubule (GO:0047496)3.16083780
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15088269
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.14189510
86protein complex biogenesis (GO:0070271)3.13197389
87regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.12575612
88regulation of neurotransmitter secretion (GO:0046928)3.11641801
89long-term synaptic potentiation (GO:0060291)3.10864369
90proline transport (GO:0015824)3.10588597
91neuromuscular process controlling posture (GO:0050884)3.10252700
92positive regulation of neurotransmitter secretion (GO:0001956)3.10102815
93cerebellar Purkinje cell differentiation (GO:0021702)3.09932764
94protein-cofactor linkage (GO:0018065)3.08700803
95prepulse inhibition (GO:0060134)3.08471214
96positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07766460
97regulation of vesicle fusion (GO:0031338)3.07547340
98somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07537240
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07537240
100isotype switching (GO:0045190)3.07537240
101respiratory electron transport chain (GO:0022904)3.07201192
102termination of RNA polymerase III transcription (GO:0006386)3.06491459
103transcription elongation from RNA polymerase III promoter (GO:0006385)3.06491459
104regulation of mitotic spindle checkpoint (GO:1903504)3.06029027
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06029027
106DNA catabolic process, exonucleolytic (GO:0000738)3.05898517
107membrane repolarization (GO:0086009)3.05598886
108neuron recognition (GO:0008038)3.05386234
109regulation of neurotransmitter levels (GO:0001505)3.05001944
110regulation of DNA endoreduplication (GO:0032875)3.04006195
111electron transport chain (GO:0022900)3.03947639
112postreplication repair (GO:0006301)3.02750247
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02017124
114membrane depolarization during action potential (GO:0086010)3.01562960
115positive regulation of dendritic spine morphogenesis (GO:0061003)3.01093756
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.99166285
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99002241
118synaptic vesicle endocytosis (GO:0048488)2.98938930
119protein prenylation (GO:0018342)2.98219153
120prenylation (GO:0097354)2.98219153
121synapsis (GO:0007129)2.97955972
122innervation (GO:0060384)2.96933329
123establishment of nucleus localization (GO:0040023)2.96919054
124regulation of cellular amino acid metabolic process (GO:0006521)2.96046661
125striatum development (GO:0021756)2.95926808
126lactate metabolic process (GO:0006089)2.95568490
127dopamine receptor signaling pathway (GO:0007212)2.94878690
128histone mRNA metabolic process (GO:0008334)2.94805907
129replication fork processing (GO:0031297)2.94379760
130protein neddylation (GO:0045116)2.93042267
131histone exchange (GO:0043486)2.92490152
132maturation of 5.8S rRNA (GO:0000460)2.91031979
133membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90538282
134regulation of neurotransmitter transport (GO:0051588)2.90011515
135dendritic spine organization (GO:0097061)2.89499388
136membrane hyperpolarization (GO:0060081)2.87868916
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87781742
138negative regulation of ligase activity (GO:0051352)2.87781742
139behavioral defense response (GO:0002209)2.87499002
140behavioral fear response (GO:0001662)2.87499002
141DNA damage response, detection of DNA damage (GO:0042769)2.87301610
142purine nucleobase biosynthetic process (GO:0009113)2.85807618
143attachment of spindle microtubules to kinetochore (GO:0008608)2.85306559
144positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84741715
145axonal fasciculation (GO:0007413)2.84702466
146mitochondrial RNA metabolic process (GO:0000959)2.83836585
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83399995
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.82348480
149mismatch repair (GO:0006298)2.82191325
150detection of calcium ion (GO:0005513)2.81173377
151membrane depolarization (GO:0051899)2.80292960
152adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.80248391
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.79767577
154regulation of ion transmembrane transporter activity (GO:0032412)2.79576171
155positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79477059
156mitochondrial respiratory chain complex I assembly (GO:0032981)2.78721953
157NADH dehydrogenase complex assembly (GO:0010257)2.78721953
158mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78721953
159cerebellar Purkinje cell layer development (GO:0021680)2.78658166
160regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.77149585
161gamma-aminobutyric acid signaling pathway (GO:0007214)2.76961263
162positive regulation of synaptic transmission (GO:0050806)2.76784601
163fear response (GO:0042596)2.76754732
164regulation of calcium ion transmembrane transport (GO:1903169)2.75706801
165regulation of calcium ion transmembrane transporter activity (GO:1901019)2.75706801
166ribosome assembly (GO:0042255)2.75532857
167regulation of voltage-gated calcium channel activity (GO:1901385)2.75500632
168regulation of membrane repolarization (GO:0060306)2.75328113
169organelle transport along microtubule (GO:0072384)2.74948581
170behavioral response to cocaine (GO:0048148)2.74778430
171negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74772288
172tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73682773
173RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73682773
174oxidative phosphorylation (GO:0006119)2.73495120
175signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73364103
176signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73364103
177signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73364103
178DNA replication checkpoint (GO:0000076)2.72879327
179recombinational repair (GO:0000725)2.72496013
180mitochondrial DNA replication (GO:0006264)2.71432045
181double-strand break repair via homologous recombination (GO:0000724)2.71377542
182transcription from mitochondrial promoter (GO:0006390)2.70031344
183DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69391927
184signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66339445
185intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66339445
186positive regulation of ligase activity (GO:0051351)2.66287561
187branched-chain amino acid catabolic process (GO:0009083)2.66124713
188positive regulation of histone H3-K4 methylation (GO:0051571)2.63445450
189signal transduction involved in DNA integrity checkpoint (GO:0072401)2.61133697
190signal transduction involved in DNA damage checkpoint (GO:0072422)2.61133697
191nucleobase biosynthetic process (GO:0046112)2.60882103
192mitotic spindle checkpoint (GO:0071174)2.60245197
193spindle checkpoint (GO:0031577)2.60244524
194protein K11-linked ubiquitination (GO:0070979)2.59191732
195signal transduction involved in cell cycle checkpoint (GO:0072395)2.58370684
196anterograde synaptic vesicle transport (GO:0048490)2.58295595
197regulation of mitochondrial translation (GO:0070129)2.57976053
198amino acid activation (GO:0043038)2.57925749
199tRNA aminoacylation (GO:0043039)2.57925749
200DNA-dependent DNA replication (GO:0006261)2.57378131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.67950245
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18275245
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.68387519
4E2F7_22180533_ChIP-Seq_HELA_Human3.57485350
5RARB_27405468_Chip-Seq_BRAIN_Mouse3.51862614
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.18567112
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10751672
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10535757
9REST_21632747_ChIP-Seq_MESCs_Mouse2.94322760
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88914344
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82399387
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82399387
13ELK1_19687146_ChIP-ChIP_HELA_Human2.78805333
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75952657
15* REST_18959480_ChIP-ChIP_MESCs_Mouse2.73056516
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63699629
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59341664
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57833988
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57553591
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56412851
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55135604
22DROSHA_22980978_ChIP-Seq_HELA_Human2.54726809
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54588892
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52423847
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52320814
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.48181235
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.48116958
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46825582
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.44278845
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41413739
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40326282
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38808645
33* VDR_23849224_ChIP-Seq_CD4+_Human2.35813817
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31755092
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31492854
36EWS_26573619_Chip-Seq_HEK293_Human2.27505952
37ZNF274_21170338_ChIP-Seq_K562_Hela2.27116896
38FLI1_27457419_Chip-Seq_LIVER_Mouse2.27021930
39EZH2_27294783_Chip-Seq_ESCs_Mouse2.25304475
40GBX2_23144817_ChIP-Seq_PC3_Human2.20185093
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17867490
42SALL1_21062744_ChIP-ChIP_HESCs_Human2.15825679
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15812696
44FUS_26573619_Chip-Seq_HEK293_Human2.15008637
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14987864
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14190797
47IGF1R_20145208_ChIP-Seq_DFB_Human2.13903071
48CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12028746
49RNF2_27304074_Chip-Seq_ESCs_Mouse2.11812559
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11727055
51EED_16625203_ChIP-ChIP_MESCs_Mouse2.06931190
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06472986
53* ETS1_20019798_ChIP-Seq_JURKAT_Human2.06362297
54ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03422405
55DNAJC2_21179169_ChIP-ChIP_NT2_Human2.00856973
56IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00498362
57VDR_22108803_ChIP-Seq_LS180_Human1.98904201
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97501427
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89294841
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.88692749
61* FOXP3_21729870_ChIP-Seq_TREG_Human1.87871411
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79881437
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76744254
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74644428
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68558857
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.68140826
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.65391667
68P300_19829295_ChIP-Seq_ESCs_Human1.57646247
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55414867
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.49077846
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48437808
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48275149
73MYC_18940864_ChIP-ChIP_HL60_Human1.47295100
74AR_21572438_ChIP-Seq_LNCaP_Human1.46089026
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45741339
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45154768
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.44803256
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.44539863
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43921910
80ZNF263_19887448_ChIP-Seq_K562_Human1.42825704
81KDM2B_26808549_Chip-Seq_K562_Human1.40861013
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38548586
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35527954
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.34327026
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34200733
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34013651
87DCP1A_22483619_ChIP-Seq_HELA_Human1.32484636
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31986441
89* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30863517
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29094209
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28205060
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27464733
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25562621
94MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25283270
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.23680795
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22473399
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22176659
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.21335890
99ER_23166858_ChIP-Seq_MCF-7_Human1.20707944
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20325324
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.19376072
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18869222
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.17881369
104AR_19668381_ChIP-Seq_PC3_Human1.16142716
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15968252
106* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15758297
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15245930
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15053185
109SMAD4_21799915_ChIP-Seq_A2780_Human1.14934579
110P53_22387025_ChIP-Seq_ESCs_Mouse1.14570052
111SOX2_19829295_ChIP-Seq_ESCs_Human1.13595249
112NANOG_19829295_ChIP-Seq_ESCs_Human1.13595249
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13566208
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12553590
115* TTF2_22483619_ChIP-Seq_HELA_Human1.12327271
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10759052
117CTCF_27219007_Chip-Seq_Bcells_Human1.10619404
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10150925
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10061725
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08515162
121* GABP_19822575_ChIP-Seq_HepG2_Human1.08011880
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07902106
123* TP53_22573176_ChIP-Seq_HFKS_Human1.07415986
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07367728
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06935932
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.06916550
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06256370
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06162871
129KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05923350
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05490970
131P300_18555785_Chip-Seq_ESCs_Mouse1.05443021
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05400116
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.05265944
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04892768
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04264057
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.03948889
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03828006
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03707377
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03312560
140LXR_22292898_ChIP-Seq_THP-1_Human1.02594199
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.02180826
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02163512
143FOXA1_25329375_ChIP-Seq_VCAP_Human1.01390978
144FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01390978
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.00765141
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00222791
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00207812
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99898276
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99809055
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.99584264
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98896617
152* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97630852
153NMYC_18555785_Chip-Seq_ESCs_Mouse0.97551074
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96962747
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96557154
156SALL4_22934838_ChIP-ChIP_CD34+_Human0.95859747
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95701829
158OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95103072
159WDR5_24793694_ChIP-Seq_LNCAP_Human0.95079493
160CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94923963
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94728845
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94525096
163KDM2B_26808549_Chip-Seq_DND41_Human0.94408539
164SMC4_20622854_ChIP-Seq_HELA_Human0.93624872
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.93448426
166TFEB_21752829_ChIP-Seq_HELA_Human0.93245941
167AR_25329375_ChIP-Seq_VCAP_Human0.92877528
168* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91536412
169* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90562454
170KDM2B_26808549_Chip-Seq_JURKAT_Human0.90174259
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88705157
172EP300_21415370_ChIP-Seq_HL-1_Mouse0.87394712
173* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87208103
174RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87038970
175SMAD3_21741376_ChIP-Seq_ESCs_Human0.86631377
176CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85311233
177CREB1_26743006_Chip-Seq_LNCaP_Human0.84616791
178KLF4_19829295_ChIP-Seq_ESCs_Human0.84311171
179THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83640827
180TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80777357
181SMAD4_21741376_ChIP-Seq_ESCs_Human0.78784002
182RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78360637
183EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77185051
184TAF15_26573619_Chip-Seq_HEK293_Human0.76591025
185MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76423855
186ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75312767
187SOX3_22085726_ChIP-Seq_NPCs_Mouse0.74898627
188CBP_20019798_ChIP-Seq_JUKART_Human0.73871434
189IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73871434
190MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73429290
191RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72233125
192* STAT3_23295773_ChIP-Seq_U87_Human0.71861985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.48083247
2MP0003880_abnormal_central_pattern4.53388224
3MP0003635_abnormal_synaptic_transmissio3.98077626
4MP0000372_irregular_coat_pigmentation3.81691624
5MP0002102_abnormal_ear_morphology3.54397333
6MP0004270_analgesia3.21307584
7MP0002822_catalepsy3.20787137
8MP0008057_abnormal_DNA_replication3.14423608
9MP0008877_abnormal_DNA_methylation3.11169239
10MP0002063_abnormal_learning/memory/cond3.08595242
11MP0009745_abnormal_behavioral_response3.05444774
12MP0008058_abnormal_DNA_repair2.97531880
13MP0004147_increased_porphyrin_level2.79811318
14MP0001968_abnormal_touch/_nociception2.73599561
15MP0002064_seizures2.72184661
16MP0010094_abnormal_chromosome_stability2.70311145
17MP0009697_abnormal_copulation2.59450227
18MP0009046_muscle_twitch2.46348299
19MP0002572_abnormal_emotion/affect_behav2.38049068
20MP0005075_abnormal_melanosome_morpholog2.36619967
21MP0000751_myopathy2.33626722
22MP0002909_abnormal_adrenal_gland2.32632595
23MP0002272_abnormal_nervous_system2.26923810
24MP0002734_abnormal_mechanical_nocicepti2.24725135
25MP0005423_abnormal_somatic_nervous2.16665522
26MP0002166_altered_tumor_susceptibility2.10175572
27MP0003786_premature_aging2.10087435
28MP0003136_yellow_coat_color2.05169741
29MP0002736_abnormal_nociception_after2.04996213
30MP0003111_abnormal_nucleus_morphology2.00912826
31MP0003195_calcinosis1.96688689
32MP0003122_maternal_imprinting1.95773798
33MP0005253_abnormal_eye_physiology1.93287552
34MP0002735_abnormal_chemical_nociception1.90947112
35MP0005171_absent_coat_pigmentation1.90552122
36MP0001486_abnormal_startle_reflex1.89865354
37MP0004957_abnormal_blastocyst_morpholog1.88309873
38MP0002837_dystrophic_cardiac_calcinosis1.87349196
39MP0008569_lethality_at_weaning1.86500096
40MP0009780_abnormal_chondrocyte_physiolo1.83757542
41MP0001440_abnormal_grooming_behavior1.82226167
42MP0004811_abnormal_neuron_physiology1.80584095
43MP0003718_maternal_effect1.78231957
44MP0003329_amyloid_beta_deposits1.77058994
45MP0002184_abnormal_innervation1.70941944
46MP0004858_abnormal_nervous_system1.70753034
47MP0000013_abnormal_adipose_tissue1.70553790
48MP0006036_abnormal_mitochondrial_physio1.69758381
49MP0002733_abnormal_thermal_nociception1.67747279
50MP0004145_abnormal_muscle_electrophysio1.65370950
51MP0006276_abnormal_autonomic_nervous1.65015429
52MP0001970_abnormal_pain_threshold1.64320809
53MP0001501_abnormal_sleep_pattern1.63722907
54MP0002006_tumorigenesis1.63465913
55MP0010234_abnormal_vibrissa_follicle1.63336342
56MP0002067_abnormal_sensory_capabilities1.62709849
57MP0003077_abnormal_cell_cycle1.60190857
58MP0005379_endocrine/exocrine_gland_phen1.58958749
59MP0003693_abnormal_embryo_hatching1.58390296
60MP0003806_abnormal_nucleotide_metabolis1.58069547
61MP0002095_abnormal_skin_pigmentation1.58051364
62MP0003879_abnormal_hair_cell1.57767732
63MP0002009_preneoplasia1.57690788
64MP0003186_abnormal_redox_activity1.55131353
65MP0004215_abnormal_myocardial_fiber1.54819894
66MP0002938_white_spotting1.53751199
67MP0005408_hypopigmentation1.53023470
68MP0004924_abnormal_behavior1.51578402
69MP0005386_behavior/neurological_phenoty1.51578402
70MP0005646_abnormal_pituitary_gland1.49150367
71MP0001984_abnormal_olfaction1.48903170
72MP0005174_abnormal_tail_pigmentation1.47259545
73MP0002557_abnormal_social/conspecific_i1.47000590
74MP0005084_abnormal_gallbladder_morpholo1.44459808
75MP0008007_abnormal_cellular_replicative1.41960521
76MP0002163_abnormal_gland_morphology1.39719985
77MP0003123_paternal_imprinting1.38569032
78MP0000955_abnormal_spinal_cord1.37872170
79MP0001529_abnormal_vocalization1.34966015
80MP0004233_abnormal_muscle_weight1.32830949
81MP0008961_abnormal_basal_metabolism1.30507973
82MP0000747_muscle_weakness1.29910181
83MP0000427_abnormal_hair_cycle1.29283520
84MP0001485_abnormal_pinna_reflex1.29218974
85MP0001835_abnormal_antigen_presentation1.28695068
86MP0004084_abnormal_cardiac_muscle1.28534058
87MP0000647_abnormal_sebaceous_gland1.27951205
88MP0002066_abnormal_motor_capabilities/c1.27074560
89MP0002882_abnormal_neuron_morphology1.25976395
90MP0004085_abnormal_heartbeat1.22258547
91MP0008995_early_reproductive_senescence1.21300723
92MP0008932_abnormal_embryonic_tissue1.20383311
93MP0001661_extended_life_span1.19011087
94MP0004036_abnormal_muscle_relaxation1.19006107
95MP0001764_abnormal_homeostasis1.16753978
96MP0002160_abnormal_reproductive_system1.15356265
97MP0000778_abnormal_nervous_system1.15150853
98MP0000749_muscle_degeneration1.12574917
99MP0005377_hearing/vestibular/ear_phenot1.12047025
100MP0003878_abnormal_ear_physiology1.12047025
101MP0005389_reproductive_system_phenotype1.11876955
102MP0003937_abnormal_limbs/digits/tail_de1.10404812
103MP0001502_abnormal_circadian_rhythm1.08566646
104MP0008872_abnormal_physiological_respon1.08087956
105MP0004484_altered_response_of1.07938713
106MP0005332_abnormal_amino_acid1.05940402
107MP0005671_abnormal_response_to1.05746013
108MP0003787_abnormal_imprinting1.05579821
109MP0003011_delayed_dark_adaptation1.00300083
110MP0003633_abnormal_nervous_system1.00109895
111MP0002152_abnormal_brain_morphology0.99906086
112MP0004134_abnormal_chest_morphology0.99016103
113MP0002269_muscular_atrophy0.98934117
114MP0005623_abnormal_meninges_morphology0.98914189
115MP0010386_abnormal_urinary_bladder0.98082785
116MP0005620_abnormal_muscle_contractility0.96589763
117MP0001929_abnormal_gametogenesis0.96493910
118MP0003567_abnormal_fetal_cardiomyocyte0.95117293
119MP0004130_abnormal_muscle_cell0.94582807
120MP0010307_abnormal_tumor_latency0.93357262
121MP0001919_abnormal_reproductive_system0.92112479
122MP0006292_abnormal_olfactory_placode0.91678353
123MP0000015_abnormal_ear_pigmentation0.91402110
124MP0004885_abnormal_endolymph0.91203276
125MP0002089_abnormal_postnatal_growth/wei0.89898071
126MP0001905_abnormal_dopamine_level0.89870155
127MP0002069_abnormal_eating/drinking_beha0.88867936
128MP0001324_abnormal_eye_pigmentation0.87308388
129MP0003283_abnormal_digestive_organ0.85419501
130MP0000653_abnormal_sex_gland0.84736520
131MP0004087_abnormal_muscle_fiber0.84517228
132MP0003646_muscle_fatigue0.84208089
133MP0002638_abnormal_pupillary_reflex0.84109344
134MP0003137_abnormal_impulse_conducting0.83907726
135MP0005187_abnormal_penis_morphology0.83778728
136MP0002210_abnormal_sex_determination0.83094274
137MP0006072_abnormal_retinal_apoptosis0.83081081
138MP0002693_abnormal_pancreas_physiology0.82796213
139MP0005645_abnormal_hypothalamus_physiol0.81325407
140MP0000759_abnormal_skeletal_muscle0.81226045
141MP0001119_abnormal_female_reproductive0.79731546
142MP0005266_abnormal_metabolism0.79010465
143MP0003631_nervous_system_phenotype0.78021069
144MP0002234_abnormal_pharynx_morphology0.77916289
145MP0001188_hyperpigmentation0.77691604
146MP0005535_abnormal_body_temperature0.77635962
147MP0001293_anophthalmia0.75831568
148MP0001145_abnormal_male_reproductive0.75269626
149MP0008789_abnormal_olfactory_epithelium0.74766413
150MP0003121_genomic_imprinting0.73896497
151MP0001299_abnormal_eye_distance/0.73776205
152MP0002106_abnormal_muscle_physiology0.73159724
153MP0005220_abnormal_exocrine_pancreas0.73020727
154MP0005551_abnormal_eye_electrophysiolog0.72986365
155MP0005330_cardiomyopathy0.72509606
156MP0005391_vision/eye_phenotype0.71119790
157MP0002229_neurodegeneration0.71026004
158MP0005394_taste/olfaction_phenotype0.70691366
159MP0005499_abnormal_olfactory_system0.70691366
160MP0002972_abnormal_cardiac_muscle0.70639361
161MP0003252_abnormal_bile_duct0.70630282
162MP0006035_abnormal_mitochondrial_morpho0.70605560
163MP0002928_abnormal_bile_duct0.70375244
164MP0000534_abnormal_ureter_morphology0.69945223
165MP0000569_abnormal_digit_pigmentation0.69111561
166MP0002090_abnormal_vision0.68486029
167MP0008875_abnormal_xenobiotic_pharmacok0.65971314
168MP0004142_abnormal_muscle_tone0.64016094
169MP0000631_abnormal_neuroendocrine_gland0.62959235
170MP0002277_abnormal_respiratory_mucosa0.62908068
171MP0002653_abnormal_ependyma_morphology0.62590837
172MP0008874_decreased_physiological_sensi0.62386873
173MP0000371_diluted_coat_color0.60912424
174MP0005636_abnormal_mineral_homeostasis0.59609672
175MP0000358_abnormal_cell_content/0.59585981

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.86303450
2Myokymia (HP:0002411)5.77991867
3Visual hallucinations (HP:0002367)4.92180903
4Focal seizures (HP:0007359)4.57635927
5Epileptic encephalopathy (HP:0200134)3.48628330
6Ankle clonus (HP:0011448)3.40630994
7Atonic seizures (HP:0010819)3.37359748
8Impaired vibration sensation in the lower limbs (HP:0002166)3.32385661
9Increased hepatocellular lipid droplets (HP:0006565)3.30720757
10Renal cortical cysts (HP:0000803)3.30486688
11Acute necrotizing encephalopathy (HP:0006965)3.25356050
12Depression (HP:0000716)3.23643750
13Absence seizures (HP:0002121)3.19609409
14Abnormality of the lower motor neuron (HP:0002366)3.17261430
15Lipid accumulation in hepatocytes (HP:0006561)3.13040581
16Increased CSF lactate (HP:0002490)3.12344367
17Progressive macrocephaly (HP:0004481)3.04957048
183-Methylglutaconic aciduria (HP:0003535)3.04873482
19Mitochondrial inheritance (HP:0001427)3.02337963
20Anxiety (HP:0000739)2.97681190
21Abnormality of alanine metabolism (HP:0010916)2.97050484
22Hyperalaninemia (HP:0003348)2.97050484
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97050484
24Generalized tonic-clonic seizures (HP:0002069)2.95802409
25Annular pancreas (HP:0001734)2.95464427
26Acute encephalopathy (HP:0006846)2.95110177
27Urinary urgency (HP:0000012)2.93668458
28Pheochromocytoma (HP:0002666)2.91354296
29Poor eye contact (HP:0000817)2.89111393
30Action tremor (HP:0002345)2.85807239
31Shoulder girdle muscle weakness (HP:0003547)2.83105947
32Type I transferrin isoform profile (HP:0003642)2.82823820
33Abnormal mitochondria in muscle tissue (HP:0008316)2.82306188
34Dialeptic seizures (HP:0011146)2.82240989
35Amblyopia (HP:0000646)2.78580096
36Methylmalonic acidemia (HP:0002912)2.76856744
37Progressive cerebellar ataxia (HP:0002073)2.75908612
38Truncal ataxia (HP:0002078)2.72940362
39Abnormality of the renal cortex (HP:0011035)2.71852311
40Ventricular fibrillation (HP:0001663)2.71088751
41Papilledema (HP:0001085)2.65923882
42Febrile seizures (HP:0002373)2.61205044
43Neuroendocrine neoplasm (HP:0100634)2.59580418
44Patchy hypopigmentation of hair (HP:0011365)2.58538707
45Pancreatic cysts (HP:0001737)2.57520331
46Dysmetric saccades (HP:0000641)2.56129831
47Exercise-induced myalgia (HP:0003738)2.56057721
48Hypothermia (HP:0002045)2.54966132
49Impaired smooth pursuit (HP:0007772)2.53351025
50Hepatic necrosis (HP:0002605)2.52855769
51Large for gestational age (HP:0001520)2.52581911
52Supranuclear gaze palsy (HP:0000605)2.51482955
53Pointed chin (HP:0000307)2.51295825
54Abnormality of midbrain morphology (HP:0002418)2.50772468
55Molar tooth sign on MRI (HP:0002419)2.50772468
56Abnormality of methionine metabolism (HP:0010901)2.49916200
57Medial flaring of the eyebrow (HP:0010747)2.49325169
58Abnormal social behavior (HP:0012433)2.48318488
59Impaired social interactions (HP:0000735)2.48318488
60Urinary bladder sphincter dysfunction (HP:0002839)2.47889896
61Increased serum lactate (HP:0002151)2.47419692
62Chronic otitis media (HP:0000389)2.46924708
63Pancreatic fibrosis (HP:0100732)2.44545501
64Focal dystonia (HP:0004373)2.44281339
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41331689
66Abnormal protein N-linked glycosylation (HP:0012347)2.41331689
67Abnormal protein glycosylation (HP:0012346)2.41331689
68Abnormal glycosylation (HP:0012345)2.41331689
69Cerebral edema (HP:0002181)2.41126417
70Hepatocellular necrosis (HP:0001404)2.41076605
71Resting tremor (HP:0002322)2.40063995
72Dysdiadochokinesis (HP:0002075)2.39645194
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.37444322
74Chronic sinusitis (HP:0011109)2.36786328
75Muscle fiber atrophy (HP:0100295)2.36452714
76Short tibia (HP:0005736)2.35735175
77Bundle branch block (HP:0011710)2.35504848
78Sudden death (HP:0001699)2.35146363
79Torticollis (HP:0000473)2.34856879
80Abnormal eating behavior (HP:0100738)2.33862715
81Congenital, generalized hypertrichosis (HP:0004540)2.33217331
82Myotonia (HP:0002486)2.32321683
83Insomnia (HP:0100785)2.31352080
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29418368
85Postural instability (HP:0002172)2.29136227
86Broad-based gait (HP:0002136)2.28904503
87Gaze-evoked nystagmus (HP:0000640)2.28718978
88Craniofacial dystonia (HP:0012179)2.28366952
89Bradykinesia (HP:0002067)2.28146235
90Stereotypic behavior (HP:0000733)2.27826677
91Exercise-induced muscle cramps (HP:0003710)2.27212072
92Pelvic girdle muscle weakness (HP:0003749)2.27209024
93Renal Fanconi syndrome (HP:0001994)2.26417051
94Neoplasm of the adrenal gland (HP:0100631)2.25122425
95Neoplasm of the peripheral nervous system (HP:0100007)2.24689419
96Progressive inability to walk (HP:0002505)2.23340271
97Volvulus (HP:0002580)2.22959595
98True hermaphroditism (HP:0010459)2.22479116
99Lactic acidosis (HP:0003128)2.20904767
100Hypoventilation (HP:0002791)2.20113901
101Hyperinsulinemic hypoglycemia (HP:0000825)2.19951754
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.19135309
103Hypoplasia of the fovea (HP:0007750)2.19135309
104Abnormality of the musculature of the pelvis (HP:0001469)2.18753512
105Abnormality of the hip-girdle musculature (HP:0001445)2.18753512
106Ankyloglossia (HP:0010296)2.16124241
107Spastic gait (HP:0002064)2.15185496
108Abolished electroretinogram (ERG) (HP:0000550)2.14433826
109Hypoglycemic coma (HP:0001325)2.13663888
110Abnormality of macular pigmentation (HP:0008002)2.12611072
111Respiratory difficulties (HP:0002880)2.12546429
112Termporal pattern (HP:0011008)2.10755584
113Insidious onset (HP:0003587)2.10755584
114Abnormality of ocular smooth pursuit (HP:0000617)2.09727359
115Spinal canal stenosis (HP:0003416)2.09326025
116Rapidly progressive (HP:0003678)2.08314614
117Respiratory failure (HP:0002878)2.06787764
118Congenital primary aphakia (HP:0007707)2.06320949
119Colon cancer (HP:0003003)2.06023103
120Dysmetria (HP:0001310)2.05406781
121Nephronophthisis (HP:0000090)2.05260807
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03835399
123Gastrointestinal atresia (HP:0002589)2.02171257
124Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01805938
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01805938
126Methylmalonic aciduria (HP:0012120)2.01146713
127Difficulty climbing stairs (HP:0003551)2.01122416
128Impaired pain sensation (HP:0007328)2.01028130
129Abnormality of pain sensation (HP:0010832)2.01028130
130Abnormality of chromosome stability (HP:0003220)1.99504786
131Achilles tendon contracture (HP:0001771)1.99063767
132Abnormality of the fovea (HP:0000493)1.98981279
133Aplasia/hypoplasia of the uterus (HP:0008684)1.98291140
134Neoplasm of the heart (HP:0100544)1.97488555
135Megalencephaly (HP:0001355)1.97183230
136Ketoacidosis (HP:0001993)1.96578902
137Chromsome breakage (HP:0040012)1.94705412
138Degeneration of anterior horn cells (HP:0002398)1.94662002
139Abnormality of the anterior horn cell (HP:0006802)1.94662002
140Hypoproteinemia (HP:0003075)1.93053985
141Abnormality of serum amino acid levels (HP:0003112)1.92924863
142Congenital stationary night blindness (HP:0007642)1.92409548
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91639125
144Abnormality of vitamin B metabolism (HP:0004340)1.91597429
145Delusions (HP:0000746)1.91413787
146Lethargy (HP:0001254)1.91283364
147Limb-girdle muscle atrophy (HP:0003797)1.91077704
148Impaired vibratory sensation (HP:0002495)1.90742857
149Amyotrophic lateral sclerosis (HP:0007354)1.90691419
150Hemiplegia (HP:0002301)1.90558981
151Abnormal EKG (HP:0003115)1.89687065
152Neoplasm of the adrenal cortex (HP:0100641)1.88639141
153Increased intramyocellular lipid droplets (HP:0012240)1.88252413
154Deep palmar crease (HP:0006191)1.87635041
155Clonus (HP:0002169)1.87305089
156Hypercortisolism (HP:0001578)1.87101389
157Type II lissencephaly (HP:0007260)1.86946921
158Unsteady gait (HP:0002317)1.86084105
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85606755
160Abnormality of oral frenula (HP:0000190)1.85592354
161Epileptiform EEG discharges (HP:0011182)1.85542330
162Gait imbalance (HP:0002141)1.84511559
163Exertional dyspnea (HP:0002875)1.83863608
164Prolonged QT interval (HP:0001657)1.83732080
165Abnormality of the labia minora (HP:0012880)1.82918710
166Agitation (HP:0000713)1.82860257
167Abnormality of the renal medulla (HP:0100957)1.81797981
168Mutism (HP:0002300)1.81468790
169Intestinal atresia (HP:0011100)1.81339997
170Nephrogenic diabetes insipidus (HP:0009806)1.80118670
171Aplastic anemia (HP:0001915)1.79291989
172EEG with generalized epileptiform discharges (HP:0011198)1.79054882
173Thyroid carcinoma (HP:0002890)1.76942637
174Rimmed vacuoles (HP:0003805)1.76467097
175Pancreatic islet-cell hyperplasia (HP:0004510)1.76449660
176Myoglobinuria (HP:0002913)1.75483301
177Central scotoma (HP:0000603)1.75446237
178Failure to thrive in infancy (HP:0001531)1.75439763
179Hyperthyroidism (HP:0000836)1.75001773
180Megaloblastic anemia (HP:0001889)1.74674684
181Intellectual disability, profound (HP:0002187)1.74559215
182Lower limb muscle weakness (HP:0007340)1.74286687
183Truncus arteriosus (HP:0001660)1.74091840
184Menstrual irregularities (HP:0000858)1.73848952
185Genital tract atresia (HP:0001827)1.73287386
186Ragged-red muscle fibers (HP:0003200)1.72763737
187Abnormality of renal resorption (HP:0011038)1.72553749
188Lower limb asymmetry (HP:0100559)1.72540412
189Gonadotropin excess (HP:0000837)1.72287005
190Glycosuria (HP:0003076)1.72051964
191Abnormality of urine glucose concentration (HP:0011016)1.72051964
192Palpitations (HP:0001962)1.71619919
193Clubbing of toes (HP:0100760)1.71327757
194Glioma (HP:0009733)1.71027468
195Reduced antithrombin III activity (HP:0001976)1.70816993
196IgG deficiency (HP:0004315)1.68789042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.29998954
2NTRK34.23867870
3EPHA43.61632814
4FRK3.56989197
5MST43.31651848
6NUAK13.02485527
7KSR23.02328574
8MINK12.75585471
9MAP3K42.68654413
10EIF2AK32.49809920
11BMPR1B2.44468281
12DAPK22.39211443
13EIF2AK12.33672062
14ZAK2.32411784
15KSR12.25798717
16MAP4K22.23922631
17PRKD32.23854077
18SRPK12.17075361
19PAK62.15738167
20BUB12.15424632
21TRIM282.10775861
22CAMKK12.07082208
23MAP2K72.05604338
24TRIB32.05220830
25NEK12.03330360
26MARK12.02629933
27ARAF1.97786038
28ACVR1B1.94241250
29PKN21.93962678
30SCYL21.81326893
31DAPK11.78939028
32PLK31.77379311
33MAP2K41.74220923
34BRSK21.69703310
35TSSK61.69192058
36NTRK11.68603810
37MAP3K121.67904632
38WEE11.65107028
39CDK191.64455377
40GRK11.62906252
41TAOK11.62135637
42NTRK21.61027180
43MKNK21.53468534
44MAP3K131.52233778
45RAF11.42320644
46CDC71.40551839
47CAMKK21.38921596
48MKNK11.38192832
49BMPR21.38121298
50CDK51.35859357
51STK161.31907893
52PLK21.30514238
53PLK41.30308058
54MAP3K21.28333172
55LMTK21.25620974
56GRK71.25083520
57TTK1.24666870
58TNIK1.22690887
59WNK31.21913324
60RET1.19735072
61VRK11.18354896
62OXSR11.17847348
63ADRBK21.17780100
64STK381.15930381
65TXK1.15508744
66EIF2AK21.15000487
67SIK21.13770383
68CSNK1G11.12963504
69PBK1.12043849
70STK31.11704833
71NME11.08169969
72BCR1.07713076
73STK391.04712054
74FES1.03996457
75RIPK11.03657505
76STK38L1.03447123
77STK241.02483012
78TYRO31.00801295
79CSNK1G31.00632246
80RIPK40.99245169
81CDK180.98440878
82CDK140.97937736
83PASK0.96969865
84PAK30.96733553
85PRKCG0.95651263
86UHMK10.95480680
87NLK0.94852581
88PHKG10.94633048
89PHKG20.94633048
90CASK0.94305612
91CDK150.93891853
92VRK20.92092908
93PTK2B0.89933274
94CCNB10.89719585
95LATS20.88610479
96MAPK130.88076862
97MAP3K10.87240171
98CAMK10.86389730
99TAOK30.85366598
100LIMK10.84285490
101CDK11A0.83375212
102PINK10.83144041
103PLK10.82055317
104MAP2K10.81231729
105PRKCH0.79329990
106TAF10.79328378
107PNCK0.79117512
108CLK10.78665306
109CSNK1A1L0.76440896
110TGFBR20.75923503
111TEC0.73803236
112PDK20.72717934
113TESK10.72509275
114BRAF0.72087618
115STK100.71160212
116TGFBR10.69398496
117ALK0.68220463
118CAMK2A0.66992085
119FGFR20.66105224
120BRSK10.65268931
121INSRR0.65010013
122TLK10.64029506
123FER0.63485856
124ATR0.62751614
125LATS10.62530148
126PRPF4B0.62297783
127OBSCN0.61826187
128RPS6KA40.59428006
129MAP3K70.58590029
130CDK30.58425002
131PDGFRA0.58278373
132CDK80.58270822
133MOS0.58228218
134GRK50.56131586
135WNK40.55742444
136PDK10.55186576
137PDK40.55024120
138PDK30.55024120
139CHEK20.54177799
140DAPK30.52914634
141PRKCE0.52612367
142STK110.52209690
143ATM0.52025171
144AURKB0.51311140
145TRPM70.50745379
146SGK2230.48923894
147SGK4940.48923894
148CDC42BPA0.47982714
149RPS6KA50.47788962
150DMPK0.46709567
151CSNK1G20.46341732
152CAMK2B0.45501665
153FGFR10.45476794
154EEF2K0.45284451
155ADRBK10.44851143
156PDPK10.44640677
157DYRK1A0.43481257
158CSNK2A10.42170901
159MARK20.42076042
160SIK30.41606190
161TTN0.40732148
162MUSK0.39670315
163TIE10.39404676
164CSNK2A20.38914695
165STK40.38710263
166RPS6KA30.38293239
167SGK30.37970785
168SGK10.36875992
169YES10.36602315
170PRKCZ0.36361356
171SGK20.33351984
172ILK0.32962755
173ERBB30.32074888
174ROCK20.31035932
175CAMK40.29283921
176PRKCB0.28815532
177MAPK100.28050719

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98206422
2Protein export_Homo sapiens_hsa030603.94938883
3Synaptic vesicle cycle_Homo sapiens_hsa047213.26357051
4Nicotine addiction_Homo sapiens_hsa050333.02854162
5Long-term potentiation_Homo sapiens_hsa047202.74614468
6Olfactory transduction_Homo sapiens_hsa047402.70852406
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64778608
8Circadian entrainment_Homo sapiens_hsa047132.58472579
9Homologous recombination_Homo sapiens_hsa034402.56508292
10RNA polymerase_Homo sapiens_hsa030202.55582852
11Mismatch repair_Homo sapiens_hsa034302.54326130
12Basal transcription factors_Homo sapiens_hsa030222.52246102
13Amphetamine addiction_Homo sapiens_hsa050312.43487771
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39316222
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37618634
16GABAergic synapse_Homo sapiens_hsa047272.34816025
17Non-homologous end-joining_Homo sapiens_hsa034502.29032937
18Dopaminergic synapse_Homo sapiens_hsa047282.23319827
19RNA degradation_Homo sapiens_hsa030182.15584390
20Glutamatergic synapse_Homo sapiens_hsa047242.14608715
21Propanoate metabolism_Homo sapiens_hsa006402.14063697
22Morphine addiction_Homo sapiens_hsa050322.13200368
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12482108
24Insulin secretion_Homo sapiens_hsa049112.06762057
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05260921
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.96978903
27Salivary secretion_Homo sapiens_hsa049701.90885091
28One carbon pool by folate_Homo sapiens_hsa006701.88024129
29Ribosome_Homo sapiens_hsa030101.88020720
30Oxytocin signaling pathway_Homo sapiens_hsa049211.87067341
31Gastric acid secretion_Homo sapiens_hsa049711.86535667
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85648184
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82283994
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81992186
35Cholinergic synapse_Homo sapiens_hsa047251.79850594
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78728702
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78265383
38DNA replication_Homo sapiens_hsa030301.75050486
39Nucleotide excision repair_Homo sapiens_hsa034201.74517157
40Renin secretion_Homo sapiens_hsa049241.73886224
41RNA transport_Homo sapiens_hsa030131.69019132
42Fanconi anemia pathway_Homo sapiens_hsa034601.68025010
43Cardiac muscle contraction_Homo sapiens_hsa042601.62967539
44Spliceosome_Homo sapiens_hsa030401.61261804
45Long-term depression_Homo sapiens_hsa047301.56963157
46Cocaine addiction_Homo sapiens_hsa050301.54298964
47Selenocompound metabolism_Homo sapiens_hsa004501.51113601
48Calcium signaling pathway_Homo sapiens_hsa040201.49244987
49Gap junction_Homo sapiens_hsa045401.46058873
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45992693
51GnRH signaling pathway_Homo sapiens_hsa049121.45184473
52Caffeine metabolism_Homo sapiens_hsa002321.44063511
53Oocyte meiosis_Homo sapiens_hsa041141.39529280
54Fatty acid elongation_Homo sapiens_hsa000621.39296355
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31224514
56Serotonergic synapse_Homo sapiens_hsa047261.29600171
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.29515107
58Regulation of autophagy_Homo sapiens_hsa041401.26590589
59Taste transduction_Homo sapiens_hsa047421.24861531
60Sulfur metabolism_Homo sapiens_hsa009201.24526489
61Glioma_Homo sapiens_hsa052141.22828409
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.21649622
63Dilated cardiomyopathy_Homo sapiens_hsa054141.21620596
64Purine metabolism_Homo sapiens_hsa002301.21372228
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19783643
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19080454
67Collecting duct acid secretion_Homo sapiens_hsa049661.15967087
68Estrogen signaling pathway_Homo sapiens_hsa049151.15743815
69Butanoate metabolism_Homo sapiens_hsa006501.15731785
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15709630
71Vibrio cholerae infection_Homo sapiens_hsa051101.14507025
72cAMP signaling pathway_Homo sapiens_hsa040241.12304070
73Pyrimidine metabolism_Homo sapiens_hsa002401.10239901
74Type II diabetes mellitus_Homo sapiens_hsa049301.10001339
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09797059
76Base excision repair_Homo sapiens_hsa034101.07376231
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07174665
78Folate biosynthesis_Homo sapiens_hsa007901.04373303
79Peroxisome_Homo sapiens_hsa041461.02474543
80Vitamin B6 metabolism_Homo sapiens_hsa007501.01083721
81Pyruvate metabolism_Homo sapiens_hsa006201.00823113
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99502364
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.98739531
84Glucagon signaling pathway_Homo sapiens_hsa049220.97685712
85Melanogenesis_Homo sapiens_hsa049160.97665707
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97328343
87Cell cycle_Homo sapiens_hsa041100.95028643
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91537632
89VEGF signaling pathway_Homo sapiens_hsa043700.91291850
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89005449
91Phototransduction_Homo sapiens_hsa047440.88354490
92beta-Alanine metabolism_Homo sapiens_hsa004100.86649168
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84459891
94mTOR signaling pathway_Homo sapiens_hsa041500.84344499
95Parkinsons disease_Homo sapiens_hsa050120.84003340
96ErbB signaling pathway_Homo sapiens_hsa040120.83336296
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82971861
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82179171
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81614770
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79802959
101Alzheimers disease_Homo sapiens_hsa050100.79293935
102Tryptophan metabolism_Homo sapiens_hsa003800.79068017
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79044818
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.79035668
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78700119
106Primary immunodeficiency_Homo sapiens_hsa053400.78687289
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78674903
108Pancreatic secretion_Homo sapiens_hsa049720.78084608
109Thyroid hormone synthesis_Homo sapiens_hsa049180.77910982
110Axon guidance_Homo sapiens_hsa043600.75188161
111Metabolic pathways_Homo sapiens_hsa011000.75005233
112Insulin signaling pathway_Homo sapiens_hsa049100.74277811
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.73664351
114Alcoholism_Homo sapiens_hsa050340.71892424
115Non-small cell lung cancer_Homo sapiens_hsa052230.71395590
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67963938
117Steroid biosynthesis_Homo sapiens_hsa001000.66972897
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66573389
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65743860
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65640711
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.65640386
122Fatty acid degradation_Homo sapiens_hsa000710.64118977
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62911124
124Circadian rhythm_Homo sapiens_hsa047100.62456562
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62313570
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60964740
127Fatty acid metabolism_Homo sapiens_hsa012120.60734974
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.60634284
129MAPK signaling pathway_Homo sapiens_hsa040100.59696356
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59421814
131ABC transporters_Homo sapiens_hsa020100.58881045
132Oxidative phosphorylation_Homo sapiens_hsa001900.58275597
133Nitrogen metabolism_Homo sapiens_hsa009100.58093239
134Glutathione metabolism_Homo sapiens_hsa004800.57382904
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56845587
136Thyroid cancer_Homo sapiens_hsa052160.55649370
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55335392
138Dorso-ventral axis formation_Homo sapiens_hsa043200.55255905
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54961419
140p53 signaling pathway_Homo sapiens_hsa041150.54392217
141Endometrial cancer_Homo sapiens_hsa052130.52916546
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51927753
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49894492
144Endocytosis_Homo sapiens_hsa041440.49386367
145Rap1 signaling pathway_Homo sapiens_hsa040150.49362789
146Prion diseases_Homo sapiens_hsa050200.48894085
147Renal cell carcinoma_Homo sapiens_hsa052110.47653115
148Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47361403
149Colorectal cancer_Homo sapiens_hsa052100.45926644
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45592251
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.44830357
152Huntingtons disease_Homo sapiens_hsa050160.44611046
153Choline metabolism in cancer_Homo sapiens_hsa052310.43778754
154Asthma_Homo sapiens_hsa053100.43761308
155Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43332506
156HIF-1 signaling pathway_Homo sapiens_hsa040660.43026520
157Chemical carcinogenesis_Homo sapiens_hsa052040.40381448
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40192015
159Arginine and proline metabolism_Homo sapiens_hsa003300.39161357
160Wnt signaling pathway_Homo sapiens_hsa043100.38734684
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36741873
162Type I diabetes mellitus_Homo sapiens_hsa049400.36101412
163AMPK signaling pathway_Homo sapiens_hsa041520.35859491
164Antigen processing and presentation_Homo sapiens_hsa046120.35176620
165Inositol phosphate metabolism_Homo sapiens_hsa005620.34846898
166Legionellosis_Homo sapiens_hsa051340.34360765
167Ras signaling pathway_Homo sapiens_hsa040140.34289337
168Retinol metabolism_Homo sapiens_hsa008300.34205657
169Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33920071
170Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33911150
171Carbon metabolism_Homo sapiens_hsa012000.33482117
172Ether lipid metabolism_Homo sapiens_hsa005650.32296487
173mRNA surveillance pathway_Homo sapiens_hsa030150.32123790
174Biosynthesis of amino acids_Homo sapiens_hsa012300.31537405
175Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31168423
176Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29361420
177Linoleic acid metabolism_Homo sapiens_hsa005910.28883508
178N-Glycan biosynthesis_Homo sapiens_hsa005100.28155714
179Histidine metabolism_Homo sapiens_hsa003400.28150532
180Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26475613
181Sphingolipid metabolism_Homo sapiens_hsa006000.25649416
182Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24325773
183Mineral absorption_Homo sapiens_hsa049780.24129511
184Steroid hormone biosynthesis_Homo sapiens_hsa001400.23251849

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