TSNAX-DISC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.99207679
2microglial cell activation (GO:0001774)5.38549380
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.14365679
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.14365679
5modulation by symbiont of host immune response (GO:0052553)5.14365679
6positive regulation by symbiont of host defense response (GO:0052509)5.14365679
7modulation by symbiont of host defense response (GO:0052031)5.14365679
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.14365679
9positive regulation of gamma-delta T cell activation (GO:0046645)5.06217046
10macrophage activation involved in immune response (GO:0002281)4.96635086
11response to peptidoglycan (GO:0032494)4.61806487
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.56897303
13regulation of hypersensitivity (GO:0002883)4.39686777
14macrophage activation (GO:0042116)4.38899340
15cellular response to ethanol (GO:0071361)4.38864023
16positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.38707903
17positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.19531407
18dosage compensation (GO:0007549)4.18022594
19detection of external biotic stimulus (GO:0098581)4.17408560
20cellular extravasation (GO:0045123)3.96085526
21mature B cell differentiation involved in immune response (GO:0002313)3.95948180
22response to muramyl dipeptide (GO:0032495)3.93673033
23hepatocyte apoptotic process (GO:0097284)3.90439317
24regulation of myeloid leukocyte mediated immunity (GO:0002886)3.78890100
25response to host immune response (GO:0052572)3.74708506
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74708506
27determination of adult lifespan (GO:0008340)3.69560254
28myeloid leukocyte mediated immunity (GO:0002444)3.67711382
29regulation of MHC class I biosynthetic process (GO:0045343)3.67431739
30neutrophil mediated immunity (GO:0002446)3.67208005
31histone mRNA catabolic process (GO:0071044)3.64801175
32myeloid cell activation involved in immune response (GO:0002275)3.61049047
33detection of biotic stimulus (GO:0009595)3.60796709
34regulation of B cell receptor signaling pathway (GO:0050855)3.57558063
35negative regulation of interleukin-12 production (GO:0032695)3.57400899
36detection of other organism (GO:0098543)3.53495457
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50208492
38response to host (GO:0075136)3.50208492
39response to host defenses (GO:0052200)3.50208492
40T-helper cell differentiation (GO:0042093)3.49660670
41CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.49660670
42neutrophil activation involved in immune response (GO:0002283)3.46824883
43negative regulation of inclusion body assembly (GO:0090084)3.45596035
44nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.43394375
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.35760437
46positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33442368
47positive regulation of B cell differentiation (GO:0045579)3.32988268
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.28753087
49mature B cell differentiation (GO:0002335)3.28032598
50establishment of protein localization to Golgi (GO:0072600)3.25603676
51protein targeting to Golgi (GO:0000042)3.25355335
52regulation of gamma-delta T cell activation (GO:0046643)3.23992201
53peptide catabolic process (GO:0043171)3.23036895
54positive regulation of granulocyte differentiation (GO:0030854)3.22895487
55regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.21148343
56positive regulation of cellular amide metabolic process (GO:0034250)3.17517752
57regulation of mast cell degranulation (GO:0043304)3.13606085
58I-kappaB phosphorylation (GO:0007252)3.12714619
59B cell receptor signaling pathway (GO:0050853)3.10321187
60negative regulation of DNA repair (GO:0045738)3.08721727
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05275300
62histone H3-K4 trimethylation (GO:0080182)3.04611419
63nuclear pore complex assembly (GO:0051292)3.02225857
64regulation of mast cell activation involved in immune response (GO:0033006)2.99975664
65definitive hemopoiesis (GO:0060216)2.98793022
66iron ion import (GO:0097286)2.98330119
67positive regulation of microtubule polymerization (GO:0031116)2.98013584
68negative regulation of granulocyte differentiation (GO:0030853)2.94812674
69germ cell migration (GO:0008354)2.94393104
70phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.92623985
71nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.91240652
72regulation of beta-amyloid formation (GO:1902003)2.90567761
73regulation of mast cell activation (GO:0033003)2.89248027
74embryonic process involved in female pregnancy (GO:0060136)2.89192730
75T cell differentiation involved in immune response (GO:0002292)2.88776095
76alpha-beta T cell differentiation involved in immune response (GO:0002293)2.88776095
77alpha-beta T cell activation involved in immune response (GO:0002287)2.88776095
78negative regulation of T-helper cell differentiation (GO:0045623)2.85227061
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85227061
80detection of bacterium (GO:0016045)2.82874730
81positive regulation of chemokine secretion (GO:0090197)2.81227006
82cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.80156055
83CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.78697835
84positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.78580298
85positive regulation of mast cell activation involved in immune response (GO:0033008)2.76431839
86positive regulation of mast cell degranulation (GO:0043306)2.76431839
87regulation of interleukin-6 biosynthetic process (GO:0045408)2.76416365
88monoubiquitinated protein deubiquitination (GO:0035520)2.76047276
89regulation of macrophage cytokine production (GO:0010935)2.73561223
90regulation of granulocyte differentiation (GO:0030852)2.72849108
91cell activation involved in immune response (GO:0002263)2.72005823
92leukocyte activation involved in immune response (GO:0002366)2.72005823
93protein K11-linked deubiquitination (GO:0035871)2.70724567
94neural tube formation (GO:0001841)2.69717468
95regulation of gamma-delta T cell differentiation (GO:0045586)2.68046870
96regulation of leukocyte degranulation (GO:0043300)2.67471978
97negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.67449549
98regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.67271206
99T cell activation involved in immune response (GO:0002286)2.65206193
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64859684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.09190527
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.91261767
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74927278
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.34273535
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.08270866
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96378983
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78360184
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74280408
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73483108
10SCL_19346495_ChIP-Seq_HPC-7_Human2.72584830
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.64515156
12RUNX_20019798_ChIP-Seq_JUKART_Human2.63389024
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58972004
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.45093324
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44361156
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.34653790
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24999375
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.21004759
19* SPI1_23547873_ChIP-Seq_NB4_Human2.20739373
20MYB_26560356_Chip-Seq_TH2_Human2.13526207
21VDR_24787735_ChIP-Seq_THP-1_Human2.13042342
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.09024580
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01947317
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98387153
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.97506023
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96204753
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95206528
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.94019818
29E2F7_22180533_ChIP-Seq_HELA_Human1.90463083
30MYB_26560356_Chip-Seq_TH1_Human1.85408082
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.79978397
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76241506
33SPI1_23127762_ChIP-Seq_K562_Human1.71475755
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69320385
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60630650
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59485496
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.58111407
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56910295
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55393480
40* GATA3_27048872_Chip-Seq_THYMUS_Human1.52029720
41* GATA3_26560356_Chip-Seq_TH2_Human1.49049913
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48899375
43BRD4_25478319_ChIP-Seq_HGPS_Human1.47651954
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47618371
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46476952
46VDR_24763502_ChIP-Seq_THP-1_Human1.39409645
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37714367
48GATA1_22025678_ChIP-Seq_K562_Human1.37626995
49SALL4_22934838_ChIP-ChIP_CD34+_Human1.35325988
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33996714
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33468691
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33088949
53TP53_16413492_ChIP-PET_HCT116_Human1.32713706
54PU_27001747_Chip-Seq_BMDM_Mouse1.32272533
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.29628401
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27978205
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.23766473
58ER_23166858_ChIP-Seq_MCF-7_Human1.21230455
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.20119344
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19589878
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18323578
62* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16702650
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16459242
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15940780
65AHR_22903824_ChIP-Seq_MCF-7_Human1.15648710
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11383518
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07456906
68CJUN_26792858_Chip-Seq_BT549_Human1.05920324
69SMRT_27268052_Chip-Seq_Bcells_Human1.05128910
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03802537
71IGF1R_20145208_ChIP-Seq_DFB_Human1.02339847
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.00226350
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00144706
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00144706
75PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99686388
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99517696
77E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99049119
78* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98579306
79TFEB_21752829_ChIP-Seq_HELA_Human0.98101386
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97123296
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96279542
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95084616
83GATA1_19941827_ChIP-Seq_MEL_Mouse0.93954414
84E2F1_18555785_Chip-Seq_ESCs_Mouse0.93744200
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92794565
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90989651
87CMYC_18555785_Chip-Seq_ESCs_Mouse0.90513440
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.89140396
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.88887286
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88875402
91VDR_23849224_ChIP-Seq_CD4+_Human0.88167909
92TP63_23658742_ChIP-Seq_EP156T_Human0.87858356
93RUNX1_22412390_ChIP-Seq_EML_Mouse0.87084017
94FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86911966
95ELK1_19687146_ChIP-ChIP_HELA_Human0.85500485
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84235752
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84235752
98GATA2_19941826_ChIP-Seq_K562_Human0.83141331
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83012568
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81946430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.59895412
2MP0000569_abnormal_digit_pigmentation3.36982686
3MP0002166_altered_tumor_susceptibility3.21034023
4MP0002396_abnormal_hematopoietic_system3.08011575
5MP0003724_increased_susceptibility_to2.97208457
6MP0000465_gastrointestinal_hemorrhage2.81663256
7MP0008057_abnormal_DNA_replication2.78329168
8MP0001835_abnormal_antigen_presentation2.76690884
9MP0008260_abnormal_autophagy2.56568912
10MP0003828_pulmonary_edema2.54225952
11MP0003656_abnormal_erythrocyte_physiolo2.42729575
12MP0002419_abnormal_innate_immunity2.22827599
13MP0003436_decreased_susceptibility_to2.18443913
14MP0002006_tumorigenesis2.08603006
15MP0005464_abnormal_platelet_physiology1.95224753
16MP0003950_abnormal_plasma_membrane1.93944604
17MP0003763_abnormal_thymus_physiology1.89269157
18MP0003300_gastrointestinal_ulcer1.88588611
19MP0008438_abnormal_cutaneous_collagen1.85481622
20MP0000685_abnormal_immune_system1.73531411
21MP0008007_abnormal_cellular_replicative1.73252744
22MP0005410_abnormal_fertilization1.72360564
23MP0001800_abnormal_humoral_immune1.69759157
24MP0010307_abnormal_tumor_latency1.68184745
25MP0002723_abnormal_immune_serum1.65411111
26MP0005025_abnormal_response_to1.64513276
27MP0003191_abnormal_cellular_cholesterol1.62467303
28MP0002452_abnormal_antigen_presenting1.60657396
29MP0004883_abnormal_blood_vessel1.59768306
30MP0004808_abnormal_hematopoietic_stem1.59504575
31MP0003172_abnormal_lysosome_physiology1.59262762
32MP0001545_abnormal_hematopoietic_system1.57755672
33MP0005397_hematopoietic_system_phenotyp1.57755672
34MP0005310_abnormal_salivary_gland1.52377501
35MP0001819_abnormal_immune_cell1.47131986
36MP0002420_abnormal_adaptive_immunity1.46163674
37MP0002405_respiratory_system_inflammati1.45697689
38MP0001879_abnormal_lymphatic_vessel1.44634910
39MP0005000_abnormal_immune_tolerance1.43636210
40MP0005671_abnormal_response_to1.42969550
41MP0003303_peritoneal_inflammation1.42257586
42MP0000015_abnormal_ear_pigmentation1.39574678
43MP0002998_abnormal_bone_remodeling1.38926091
44MP0002398_abnormal_bone_marrow1.37853924
45MP0003221_abnormal_cardiomyocyte_apopto1.32364953
46MP0002722_abnormal_immune_system1.30609139
47MP0005076_abnormal_cell_differentiation1.30469972
48MP0001986_abnormal_taste_sensitivity1.29543075
49MP0002332_abnormal_exercise_endurance1.29482459
50MP0009785_altered_susceptibility_to1.29235254
51MP0010368_abnormal_lymphatic_system1.29188520
52MP0009697_abnormal_copulation1.26628292
53MP0001851_eye_inflammation1.26566413
54MP0000604_amyloidosis1.25453201
55MP0005164_abnormal_response_to1.23496765
56MP0000716_abnormal_immune_system1.20552575
57MP0001915_intracranial_hemorrhage1.18892117
58MP0000689_abnormal_spleen_morphology1.18601069
59MP0004947_skin_inflammation1.18337979
60MP0003279_aneurysm1.17477137
61MP0000371_diluted_coat_color1.16309675
62MP0009764_decreased_sensitivity_to1.15890377
63MP0003186_abnormal_redox_activity1.15571266
64MP0003091_abnormal_cell_migration1.14110570
65MP0005409_darkened_coat_color1.12932728
66MP0001533_abnormal_skeleton_physiology1.12488881
67MP0000749_muscle_degeneration1.11262125
68MP0006082_CNS_inflammation1.09084044
69MP0000703_abnormal_thymus_morphology1.07287626
70MP0001845_abnormal_inflammatory_respons1.06323477
71MP0000249_abnormal_blood_vessel1.05431450
72MP0002429_abnormal_blood_cell1.04718430
73MP0005387_immune_system_phenotype1.01601032
74MP0001790_abnormal_immune_system1.01601032
75MP0009115_abnormal_fat_cell0.98880221
76MP0005174_abnormal_tail_pigmentation0.91726388
77MP0002933_joint_inflammation0.90161332
78MP0005275_abnormal_skin_tensile0.89438316
79MP0003690_abnormal_glial_cell0.85884014
80MP0001853_heart_inflammation0.85129371
81MP0004381_abnormal_hair_follicle0.83830612
82MP0009763_increased_sensitivity_to0.83121377
83MP0002971_abnormal_brown_adipose0.81539807
84MP0002019_abnormal_tumor_incidence0.81040591
85MP0005647_abnormal_sex_gland0.79571908
86MP0004484_altered_response_of0.78994761
87MP0005376_homeostasis/metabolism_phenot0.78434973
88MP0003011_delayed_dark_adaptation0.78369459
89MP0010352_gastrointestinal_tract_polyps0.76774151
90MP0000733_abnormal_muscle_development0.76271736
91MP0003329_amyloid_beta_deposits0.73505637
92MP0003077_abnormal_cell_cycle0.73497720
93MP0008469_abnormal_protein_level0.72518815
94MP0001984_abnormal_olfaction0.71120383
95MP0003866_abnormal_defecation0.70954449
96MP0003075_altered_response_to0.70866429
97MP0008873_increased_physiological_sensi0.69693442
98MP0005621_abnormal_cell_physiology0.69266969
99MP0000858_altered_metastatic_potential0.68875801
100MP0006054_spinal_hemorrhage0.67202390

Predicted human phenotypes

RankGene SetZ-score
1Conjunctival telangiectasia (HP:0000524)4.60347964
2Recurrent bacterial skin infections (HP:0005406)4.41334562
3Abnormality of the vasculature of the conjunctiva (HP:0008054)4.23499256
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.17251621
5Spondylolisthesis (HP:0003302)3.95518113
6Recurrent abscess formation (HP:0002722)3.87543510
7Colitis (HP:0002583)3.67728416
8Spinal cord lesions (HP:0100561)3.63828701
9Syringomyelia (HP:0003396)3.63828701
10Mediastinal lymphadenopathy (HP:0100721)3.41073063
11Recurrent fungal infections (HP:0002841)3.38813844
12Glomerulonephritis (HP:0000099)3.38766466
13Papillary thyroid carcinoma (HP:0002895)3.36908266
14Eczematoid dermatitis (HP:0000976)3.36784290
15Chronic mucocutaneous candidiasis (HP:0002728)3.30486331
16Recurrent cutaneous fungal infections (HP:0011370)3.30486331
17Optic neuritis (HP:0100653)3.21562896
18Retrobulbar optic neuritis (HP:0100654)3.21562896
19IgM deficiency (HP:0002850)3.20308026
20Recurrent skin infections (HP:0001581)3.09433681
21Gastrointestinal infarctions (HP:0005244)3.08704181
22T lymphocytopenia (HP:0005403)2.97843598
23Gingivitis (HP:0000230)2.96908396
24Arterial tortuosity (HP:0005116)2.91814761
25Upper motor neuron abnormality (HP:0002127)2.90270374
26Abnormality of T cell number (HP:0011839)2.88102661
27Acute myeloid leukemia (HP:0004808)2.84052441
28Eosinophilia (HP:0001880)2.76931149
29Spinal muscular atrophy (HP:0007269)2.76831432
30Arterial thrombosis (HP:0004420)2.75890251
31Resting tremor (HP:0002322)2.70640958
32Orchitis (HP:0100796)2.69875195
33Osteomyelitis (HP:0002754)2.67092762
34Hypoplasia of the thymus (HP:0000778)2.64581426
35Complement deficiency (HP:0004431)2.63699566
36Spontaneous hematomas (HP:0007420)2.59712658
37Myositis (HP:0100614)2.56912284
38Recurrent viral infections (HP:0004429)2.55359784
39Recurrent gram-negative bacterial infections (HP:0005420)2.52788348
40Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.52261329
41Granulocytopenia (HP:0001913)2.51566087
42Inflammation of the large intestine (HP:0002037)2.49171869
43Hemoptysis (HP:0002105)2.45433493
44Postural instability (HP:0002172)2.41553399
45Mucosal telangiectasiae (HP:0100579)2.40591176
46Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.36222507
47Impaired platelet aggregation (HP:0003540)2.32325812
48Abnormal platelet function (HP:0011869)2.32325812
49Systemic lupus erythematosus (HP:0002725)2.32145981
50Chronic diarrhea (HP:0002028)2.31412429
51Vascular tortuosity (HP:0004948)2.28246586
52Gastrointestinal inflammation (HP:0004386)2.27800540
53Subacute progressive viral hepatitis (HP:0006572)2.26613357
54Periodontitis (HP:0000704)2.26059770
55Absent frontal sinuses (HP:0002688)2.25754275
56Abnormality of the frontal sinuses (HP:0002687)2.25742755
57Fatigue (HP:0012378)2.24139271
58Abnormality of the prostate (HP:0008775)2.24038347
59Narrow palate (HP:0000189)2.23754391
60Tubulointerstitial nephritis (HP:0001970)2.22890611
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.22619034
62Epistaxis (HP:0000421)2.21823697
63Abnormality of eosinophils (HP:0001879)2.20280994
64Cerebral aneurysm (HP:0004944)2.16687139
65Prostate neoplasm (HP:0100787)2.15180248
66Delayed closure of the anterior fontanelle (HP:0001476)2.14710965
67Cheilitis (HP:0100825)2.14604248
68Difficulty running (HP:0009046)2.14192793
69Keratoconjunctivitis sicca (HP:0001097)2.13340022
70Thickened helices (HP:0000391)2.11371559
71Leukocytosis (HP:0001974)2.09419703
72Glucose intolerance (HP:0000833)2.09393539
73Viral hepatitis (HP:0006562)2.09206970
74Metaphyseal dysplasia (HP:0100255)2.08893597
75Thyroiditis (HP:0100646)2.08793786
76Bilateral sensorineural hearing impairment (HP:0008619)2.05306810
77Short middle phalanx of the 5th finger (HP:0004220)2.05092787
78Gingival bleeding (HP:0000225)2.04798665
79Anorexia (HP:0002039)2.04417787
80Autoimmune hemolytic anemia (HP:0001890)2.01693763
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.00568463
82Amyotrophic lateral sclerosis (HP:0007354)1.98186860
83Abnormality of T cells (HP:0002843)1.96513478
84Peritonitis (HP:0002586)1.92850579
85Chest pain (HP:0100749)1.92731313
86Keratoconjunctivitis (HP:0001096)1.91272518
87Glomerulopathy (HP:0100820)1.87936117
88Myocardial infarction (HP:0001658)1.84014983
89Thyroid carcinoma (HP:0002890)1.83772122
90IgA deficiency (HP:0002720)1.83659609
91Meningitis (HP:0001287)1.83085731
92Abnormality of the peritoneum (HP:0002585)1.82385834
93Abnormality of complement system (HP:0005339)1.78940169
94Cellulitis (HP:0100658)1.78364097
95Scanning speech (HP:0002168)1.76688658
96Nephritis (HP:0000123)1.73794282
97Pulmonary embolism (HP:0002204)1.73444971
98Amyloidosis (HP:0011034)1.72821070
99Abnormal glucose tolerance (HP:0001952)1.72466620
100Broad ribs (HP:0000885)1.69506270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.72000887
2FES3.16284268
3BLK2.75000654
4PIK3CG2.65714375
5AKT32.48049673
6EIF2AK32.35964828
7MAP3K142.27557496
8ZAK2.21077473
9TXK2.20916043
10CDK82.14910264
11IKBKE2.13181131
12BMPR21.93761412
13CSF1R1.89325428
14CDK61.78243973
15KIT1.74574828
16FRK1.68201305
17JAK11.64749675
18TEC1.63925067
19MAP3K131.59595445
20JAK31.54573701
21MOS1.51745282
22PIM11.51599435
23RIPK41.50707814
24TIE11.42566761
25TNK21.42041747
26BTK1.39609444
27GRK61.38966752
28FLT31.38119281
29SRPK11.37578024
30STK41.28623294
31NEK91.26118247
32RAF11.25631755
33MAP3K31.24932720
34SCYL21.24489309
35TYK21.22442792
36EIF2AK21.20379723
37SYK1.18575595
38MAP2K31.15658729
39MAP3K21.11943718
40EIF2AK11.09768183
41CSK1.08712149
42BRD41.04987804
43CAMK1G1.04906668
44IRAK11.02628593
45IKBKB1.02478930
46LYN1.01281784
47MAP4K11.00199670
48FGR0.98410941
49FGFR30.97468571
50MAPK70.97277654
51TBK10.97086487
52NEK60.96989239
53CDK30.96973274
54GRK70.96872270
55TRPM70.96043343
56HCK0.94017247
57JAK20.90504980
58PKN10.86704887
59PDK10.86571347
60PDK20.86141215
61LCK0.86060941
62YES10.84053701
63TLK10.83923090
64NUAK10.80163725
65STK100.78953080
66IRAK40.77734649
67EGFR0.77440656
68CAMK1D0.74266118
69RPS6KA50.73418960
70MAP3K70.70813468
71DYRK1B0.68796667
72STK380.67528751
73MAPK110.66511521
74SGK20.64619387
75CCNB10.64396650
76ZAP700.62333416
77SGK30.62298179
78BMPR1B0.56565178
79CDK90.56054999
80ITK0.54221557
81TAOK30.53832656
82MARK30.50086943
83DMPK0.47999748
84PLK20.47960715
85MAP3K120.47608341
86EPHA30.45566241
87MAP3K60.45440382
88RPS6KB20.45288365
89TESK20.45227455
90ABL10.44089180
91CAMK40.42338942
92PRKAA20.41598291
93STK160.41581877
94MAPK40.41046349
95RET0.40908269
96LATS10.39753635
97IRAK20.37271716
98MTOR0.35324739
99WNK10.35049766
100PDPK10.34703797

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.01481254
2Leishmaniasis_Homo sapiens_hsa051402.68732819
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.50961177
4Legionellosis_Homo sapiens_hsa051342.47364676
5Staphylococcus aureus infection_Homo sapiens_hsa051502.42418008
6Osteoclast differentiation_Homo sapiens_hsa043802.14451480
7B cell receptor signaling pathway_Homo sapiens_hsa046622.08470721
8Fatty acid biosynthesis_Homo sapiens_hsa000612.04105368
9Non-small cell lung cancer_Homo sapiens_hsa052231.91727794
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85896724
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73805749
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68331707
13Measles_Homo sapiens_hsa051621.68224311
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62657587
15Tuberculosis_Homo sapiens_hsa051521.60878409
16Other glycan degradation_Homo sapiens_hsa005111.58294113
17Acute myeloid leukemia_Homo sapiens_hsa052211.53003760
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47522578
19Influenza A_Homo sapiens_hsa051641.46270406
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44887267
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44596257
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42141417
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41861099
24Hepatitis B_Homo sapiens_hsa051611.41366799
25Chronic myeloid leukemia_Homo sapiens_hsa052201.40173408
26Pertussis_Homo sapiens_hsa051331.39894064
27Alcoholism_Homo sapiens_hsa050341.37802563
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36746626
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36509571
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.36207031
31Platelet activation_Homo sapiens_hsa046111.35435402
32Toxoplasmosis_Homo sapiens_hsa051451.33648384
33Viral carcinogenesis_Homo sapiens_hsa052031.30498058
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29142950
35Hematopoietic cell lineage_Homo sapiens_hsa046401.25326328
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.23664034
37Pancreatic cancer_Homo sapiens_hsa052121.22841884
38Inositol phosphate metabolism_Homo sapiens_hsa005621.20194878
39TNF signaling pathway_Homo sapiens_hsa046681.13249915
40Phagosome_Homo sapiens_hsa041451.11312969
41Malaria_Homo sapiens_hsa051441.09083662
42Herpes simplex infection_Homo sapiens_hsa051681.04397210
43Nucleotide excision repair_Homo sapiens_hsa034201.03121046
44FoxO signaling pathway_Homo sapiens_hsa040681.03035405
45HIF-1 signaling pathway_Homo sapiens_hsa040661.00273128
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98714709
47Apoptosis_Homo sapiens_hsa042100.97054540
48Dorso-ventral axis formation_Homo sapiens_hsa043200.86316799
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85298005
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85294598
51Fanconi anemia pathway_Homo sapiens_hsa034600.84855345
52Small cell lung cancer_Homo sapiens_hsa052220.84470333
53Asthma_Homo sapiens_hsa053100.84273085
54Non-homologous end-joining_Homo sapiens_hsa034500.83989694
55Circadian rhythm_Homo sapiens_hsa047100.82173336
56Antigen processing and presentation_Homo sapiens_hsa046120.82136928
57T cell receptor signaling pathway_Homo sapiens_hsa046600.81540316
58Graft-versus-host disease_Homo sapiens_hsa053320.79047674
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.78651555
60Viral myocarditis_Homo sapiens_hsa054160.76354514
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74514016
62DNA replication_Homo sapiens_hsa030300.74508013
63Chemokine signaling pathway_Homo sapiens_hsa040620.73635958
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73026814
65Complement and coagulation cascades_Homo sapiens_hsa046100.72400470
66Glioma_Homo sapiens_hsa052140.71402140
67Colorectal cancer_Homo sapiens_hsa052100.67868802
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.65946607
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.64985905
70Autoimmune thyroid disease_Homo sapiens_hsa053200.64799507
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.64362888
72Allograft rejection_Homo sapiens_hsa053300.63774401
73mTOR signaling pathway_Homo sapiens_hsa041500.63134298
74p53 signaling pathway_Homo sapiens_hsa041150.61707093
75Endometrial cancer_Homo sapiens_hsa052130.61587297
76Prostate cancer_Homo sapiens_hsa052150.61517416
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60620420
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60550756
79Rheumatoid arthritis_Homo sapiens_hsa053230.59031046
80African trypanosomiasis_Homo sapiens_hsa051430.58486882
81Prolactin signaling pathway_Homo sapiens_hsa049170.54686555
82Choline metabolism in cancer_Homo sapiens_hsa052310.54137384
83Renal cell carcinoma_Homo sapiens_hsa052110.54131895
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53985101
85Prion diseases_Homo sapiens_hsa050200.52957139
86MicroRNAs in cancer_Homo sapiens_hsa052060.52247854
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51543759
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50392092
89Shigellosis_Homo sapiens_hsa051310.49965603
90Epstein-Barr virus infection_Homo sapiens_hsa051690.48743459
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46481980
92Amoebiasis_Homo sapiens_hsa051460.46244290
93Lysine degradation_Homo sapiens_hsa003100.46238177
94HTLV-I infection_Homo sapiens_hsa051660.44733935
95Mismatch repair_Homo sapiens_hsa034300.44151272
96Regulation of autophagy_Homo sapiens_hsa041400.43954858
97Hepatitis C_Homo sapiens_hsa051600.41421324
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.41308657
99Estrogen signaling pathway_Homo sapiens_hsa049150.40934414
100ErbB signaling pathway_Homo sapiens_hsa040120.40479203

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »