TSPAN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.14833644
2intestinal epithelial cell development (GO:0060576)7.57299573
3left/right pattern formation (GO:0060972)7.33373730
4diterpenoid biosynthetic process (GO:0016102)6.90968511
5UDP-N-acetylglucosamine metabolic process (GO:0006047)6.81451458
6artery development (GO:0060840)6.63919748
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.49402802
8sulfur amino acid catabolic process (GO:0000098)6.40676334
9regulation of cilium movement (GO:0003352)6.09200115
10branching involved in prostate gland morphogenesis (GO:0060442)5.99366735
11calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.60872861
12regulation of guanylate cyclase activity (GO:0031282)5.53846655
13left/right axis specification (GO:0070986)5.40969734
14sperm capacitation (GO:0048240)5.28529050
15ventricular system development (GO:0021591)5.14586799
16L-fucose catabolic process (GO:0042355)5.13731794
17fucose catabolic process (GO:0019317)5.13731794
18L-fucose metabolic process (GO:0042354)5.13731794
19bile acid and bile salt transport (GO:0015721)5.11374752
20microtubule bundle formation (GO:0001578)5.09775927
21prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.09239542
22maintenance of gastrointestinal epithelium (GO:0030277)5.03200333
23one-carbon compound transport (GO:0019755)5.01444024
24galactose catabolic process (GO:0019388)5.01393712
25negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.96197340
26hypotonic response (GO:0006971)4.83192095
27terpenoid biosynthetic process (GO:0016114)4.77178080
28desmosome organization (GO:0002934)4.68879811
29intraciliary transport (GO:0042073)4.58410858
30lung epithelium development (GO:0060428)4.56800224
31retinoic acid metabolic process (GO:0042573)4.56378289
32positive regulation of guanylate cyclase activity (GO:0031284)4.47643682
33lung secretory cell differentiation (GO:0061140)4.46771761
34negative regulation of T cell differentiation in thymus (GO:0033085)4.45377252
35sulfate transmembrane transport (GO:1902358)4.41942178
36nucleotide-sugar biosynthetic process (GO:0009226)4.41610456
37tolerance induction (GO:0002507)4.41566508
38cilium organization (GO:0044782)4.41106689
39establishment of apical/basal cell polarity (GO:0035089)4.29628817
40glomerular epithelial cell development (GO:0072310)4.29218608
41cellular ketone body metabolic process (GO:0046950)4.29089271
42cilium assembly (GO:0042384)4.28571401
43response to xenobiotic stimulus (GO:0009410)4.22564714
44negative regulation of humoral immune response (GO:0002921)4.17175761
45oligosaccharide biosynthetic process (GO:0009312)4.16662113
46hemidesmosome assembly (GO:0031581)4.15979004
47O-glycan processing (GO:0016266)4.11433489
48primary alcohol metabolic process (GO:0034308)4.08517134
49N-glycan processing (GO:0006491)4.07350993
50epithelial structure maintenance (GO:0010669)3.99183967
513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.98464747
52purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.98464747
53retinol metabolic process (GO:0042572)3.97125074
54regulation of interleukin-5 production (GO:0032674)3.94721813
55fucose metabolic process (GO:0006004)3.83937907
56centriole assembly (GO:0098534)3.82562727
57antibacterial humoral response (GO:0019731)3.82208886
58negative regulation of B cell mediated immunity (GO:0002713)3.80503069
59negative regulation of immunoglobulin mediated immune response (GO:0002890)3.80503069
60nucleotide-sugar metabolic process (GO:0009225)3.76036245
61regulation of protein glycosylation (GO:0060049)3.73294621
62positive regulation of glycoprotein metabolic process (GO:1903020)3.71008597
63ketone body metabolic process (GO:1902224)3.69975721
64regulation of interleukin-13 production (GO:0032656)3.69424153
65positive regulation of glycoprotein biosynthetic process (GO:0010560)3.68889013
66GDP-mannose metabolic process (GO:0019673)3.64734074
67production of molecular mediator involved in inflammatory response (GO:0002532)3.64023989
68regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.63389164
69negative regulation of protein tyrosine kinase activity (GO:0061099)3.62512864
70antimicrobial humoral response (GO:0019730)3.61991247
71establishment of monopolar cell polarity (GO:0061162)3.59527748
72establishment or maintenance of monopolar cell polarity (GO:0061339)3.59527748
73cGMP-mediated signaling (GO:0019934)3.59497536
74prostate gland epithelium morphogenesis (GO:0060740)3.58956364
75glandular epithelial cell differentiation (GO:0002067)3.58080353
76phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.54757573
77regulation of cGMP biosynthetic process (GO:0030826)3.54649656
78exogenous drug catabolic process (GO:0042738)3.53110466
79sulfate transport (GO:0008272)3.52793968
80ethanol metabolic process (GO:0006067)3.52412590
81regulation of germinal center formation (GO:0002634)3.50954489
82microtubule-based movement (GO:0007018)3.50909075
83regulation of microtubule-based movement (GO:0060632)3.50835292
84phosphatidylcholine biosynthetic process (GO:0006656)3.50048713
85protein localization to cilium (GO:0061512)3.49367832
86L-serine transport (GO:0015825)3.47449018
87epithelial cell differentiation involved in prostate gland development (GO:0060742)3.45837983
88ethanol oxidation (GO:0006069)3.44885410
89peptidyl-tyrosine autophosphorylation (GO:0038083)3.42539504
90transcytosis (GO:0045056)3.40778548
91excretion (GO:0007588)3.40152759
92morphogenesis of an epithelial fold (GO:0060571)3.38529575
93mannose metabolic process (GO:0006013)3.38306322
94cell projection assembly (GO:0030031)3.37942559
95cellular component assembly involved in morphogenesis (GO:0010927)3.36557417
96actin filament depolymerization (GO:0030042)3.34409107
97epithelial cell maturation (GO:0002070)3.32588781
98progesterone metabolic process (GO:0042448)3.32031667
99water homeostasis (GO:0030104)3.31904613
100regulation of T cell tolerance induction (GO:0002664)3.26424794
101glutathione derivative biosynthetic process (GO:1901687)3.21713443
102glutathione derivative metabolic process (GO:1901685)3.21713443
103Golgi transport vesicle coating (GO:0048200)3.21364473
104COPI coating of Golgi vesicle (GO:0048205)3.21364473
105sodium ion homeostasis (GO:0055078)3.20836742
106regulation of water loss via skin (GO:0033561)3.19053415
107primary alcohol catabolic process (GO:0034310)3.18095708
108galactose metabolic process (GO:0006012)3.17382282
109protein O-linked glycosylation (GO:0006493)3.16125391
110neurotransmitter biosynthetic process (GO:0042136)3.15587057
111hepatocyte apoptotic process (GO:0097284)3.12658971
112regulation of pH (GO:0006885)3.11118972
113hexose catabolic process (GO:0019320)3.11023797
114ventricular cardiac muscle cell action potential (GO:0086005)3.10992871
115cytoplasmic microtubule organization (GO:0031122)3.10233476
116epithelial cell-cell adhesion (GO:0090136)3.08764572
117macrophage chemotaxis (GO:0048246)3.07483969
118bicarbonate transport (GO:0015701)3.04236918
119establishment of planar polarity (GO:0001736)3.02724881
120establishment of tissue polarity (GO:0007164)3.02724881
121diol metabolic process (GO:0034311)3.01849526
122negative regulation of inclusion body assembly (GO:0090084)3.00821190
123multicellular organismal water homeostasis (GO:0050891)3.00226369
124nucleoside diphosphate phosphorylation (GO:0006165)2.99826565
125pyrimidine ribonucleoside catabolic process (GO:0046133)2.99602868
126tight junction assembly (GO:0070830)2.93494366
127cilium morphogenesis (GO:0060271)2.93329565
128negative regulation of protein autophosphorylation (GO:0031953)2.93115744
129DNA damage induced protein phosphorylation (GO:0006975)2.92339942
130serine transport (GO:0032329)2.91009844
131regulation of tolerance induction (GO:0002643)2.90737256
132regulation of cGMP metabolic process (GO:0030823)2.90708243
133cytidine deamination (GO:0009972)2.90088091
134cytidine metabolic process (GO:0046087)2.90088091
135cytidine catabolic process (GO:0006216)2.90088091
136drug catabolic process (GO:0042737)2.88644399
137negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.87594406
138regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.86199577
139glutathione biosynthetic process (GO:0006750)2.85950174
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85549772
141potassium ion homeostasis (GO:0055075)2.83940679
142columnar/cuboidal epithelial cell development (GO:0002066)2.82554031
143cellular zinc ion homeostasis (GO:0006882)2.82508856
144positive regulation of tolerance induction (GO:0002645)2.82374678
145positive regulation of cGMP biosynthetic process (GO:0030828)2.80459848
146hydrogen peroxide biosynthetic process (GO:0050665)2.76653685
147hormone catabolic process (GO:0042447)2.76569238
148carnitine metabolic process (GO:0009437)2.76487067
149hydrogen peroxide catabolic process (GO:0042744)2.74988846
150regulation of receptor binding (GO:1900120)2.74476066
151cell communication involved in cardiac conduction (GO:0086065)2.72574713
152flavonoid metabolic process (GO:0009812)2.72060665
153negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.71983691
154establishment of skin barrier (GO:0061436)2.70404851
155regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69740536
156phosphatidylserine metabolic process (GO:0006658)2.69222539
157regulation of autophagic vacuole assembly (GO:2000785)2.68904094
158positive regulation of smoothened signaling pathway (GO:0045880)2.68657885
159regulation of vitamin metabolic process (GO:0030656)2.68471425
160zinc ion transport (GO:0006829)2.67292465
161regulation of histone phosphorylation (GO:0033127)2.67207739
162nonribosomal peptide biosynthetic process (GO:0019184)2.65646727
163negative regulation of keratinocyte proliferation (GO:0010839)2.65621627
164monosaccharide catabolic process (GO:0046365)2.64711836
165glutathione metabolic process (GO:0006749)2.64653908
166apical protein localization (GO:0045176)2.63356954
167regulation of metalloenzyme activity (GO:0048552)2.62774402
168renal absorption (GO:0070293)2.59194881
169hydrogen peroxide metabolic process (GO:0042743)2.58473015
170establishment or maintenance of apical/basal cell polarity (GO:0035088)2.57074529
171establishment or maintenance of bipolar cell polarity (GO:0061245)2.57074529
172sphingomyelin metabolic process (GO:0006684)2.55954302
173carnitine transmembrane transport (GO:1902603)2.52329553
174epoxygenase P450 pathway (GO:0019373)2.50446830
175positive regulation of respiratory burst (GO:0060267)2.49693639
176microtubule depolymerization (GO:0007019)2.44516050
177phenol-containing compound catabolic process (GO:0019336)2.43936775
178polyol transport (GO:0015791)2.43779703
179reactive oxygen species biosynthetic process (GO:1903409)2.42214581
180CDP-diacylglycerol biosynthetic process (GO:0016024)2.41816886
181dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.40758679
182axonemal dynein complex assembly (GO:0070286)18.3063729
183cilium or flagellum-dependent cell motility (GO:0001539)14.7482643
184cilium movement (GO:0003341)12.6795207
185motile cilium assembly (GO:0044458)12.4246558
186epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.2197080
187epithelial cilium movement (GO:0003351)10.8091682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.80727035
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.98871286
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.76212955
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.46270878
5* SOX2_20726797_ChIP-Seq_SW620_Human3.19073414
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.13227523
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.85306763
8GATA6_25053715_ChIP-Seq_YYC3_Human2.75198905
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.72809286
10GATA4_25053715_ChIP-Seq_YYC3_Human2.71505821
11DROSHA_22980978_ChIP-Seq_HELA_Human2.65733783
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.60258401
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.51627232
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19928500
15ZNF263_19887448_ChIP-Seq_K562_Human2.18874430
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.18363606
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.14500039
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11170655
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10307487
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09956209
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09048780
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.06901199
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00231531
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95570334
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90366396
26* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89851356
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89383693
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.88783274
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.86967280
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.84817687
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82004662
32AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.80934963
33KLF5_25053715_ChIP-Seq_YYC3_Human1.80840624
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.80394448
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.79938778
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78894468
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.77528279
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75360661
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71977091
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68578225
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68485245
42CLOCK_20551151_ChIP-Seq_293T_Human1.67070861
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64103697
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.63944651
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62974873
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62230457
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62230457
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60324227
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59946609
50* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.55363444
51STAT1_20625510_ChIP-Seq_HELA_Human1.55215621
52TP63_22573176_ChIP-Seq_HFKS_Human1.53562255
53* SMC4_20622854_ChIP-Seq_HELA_Human1.51286774
54GATA3_24758297_ChIP-Seq_MCF-7_Human1.50996350
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49635985
56TP63_23658742_ChIP-Seq_EP156T_Human1.45356927
57FOXA1_25552417_ChIP-Seq_VCAP_Human1.45252726
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43081155
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41894509
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.40419179
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40352566
62AHR_22903824_ChIP-Seq_MCF-7_Human1.39447908
63AR_21909140_ChIP-Seq_LNCAP_Human1.38560588
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37907550
65LXR_22292898_ChIP-Seq_THP-1_Human1.36529364
66* ATF3_27146783_Chip-Seq_COLON_Human1.35941404
67RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35830796
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33868835
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33018593
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29153860
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.28479212
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25336893
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24779649
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22992852
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22898998
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22898998
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21577315
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18223282
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18223282
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18223282
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17762493
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16312728
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.14142678
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.13215208
85* GATA1_19941826_ChIP-Seq_K562_Human1.13004496
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.12304600
87RXR_22108803_ChIP-Seq_LS180_Human1.09583007
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.09214447
89* CTCF_27219007_Chip-Seq_Bcells_Human1.07799359
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07411680
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.07071910
92P68_20966046_ChIP-Seq_HELA_Human1.05124173
93NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04478788
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03980150
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02907194
96CEBPB_22108803_ChIP-Seq_LS180_Human1.02522218
97CDX2_22108803_ChIP-Seq_LS180_Human1.01363149
98CTCF_20526341_ChIP-Seq_ESCs_Human0.99811790
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98821812
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98736017
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98614393
102PHF8_20622854_ChIP-Seq_HELA_Human0.96888955
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96042604
104TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95432280
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95310223
106GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94792201
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93472291
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93308233
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92978450
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92551445
111* GATA2_19941826_ChIP-Seq_K562_Human0.92284624
112TP53_18474530_ChIP-ChIP_U2OS_Human0.92164243
113ZNF274_21170338_ChIP-Seq_K562_Hela0.91541666
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91220097
115* ETV1_20927104_ChIP-Seq_GIST48_Human0.89898143
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.88784565
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.88724681
118BCOR_27268052_Chip-Seq_Bcells_Human0.88221853
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87982485
120* HNFA_21074721_ChIP-Seq_CACO-2_Human0.87427532
121E2F1_20622854_ChIP-Seq_HELA_Human0.87427443
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86867187
123* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86831958
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.85899650
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85819956
126* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84275655
127* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84148311
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83237327
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.82546519
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.82546519
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82007298
132SMRT_27268052_Chip-Seq_Bcells_Human0.81322416
133SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81148131
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80928151
135* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80830002
136* RBPJ_21746931_ChIP-Seq_IB4_Human0.80392565
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.80367233
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79809933
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79527978
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78695643
141* PHF8_20622853_ChIP-Seq_HELA_Human0.77864939
142* P300_27268052_Chip-Seq_Bcells_Human0.77774348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.83134820
2MP0001873_stomach_inflammation4.14739892
3MP0002653_abnormal_ependyma_morphology4.06375867
4MP0003878_abnormal_ear_physiology3.90670782
5MP0005377_hearing/vestibular/ear_phenot3.90670782
6MP0002822_catalepsy3.86847536
7MP0004264_abnormal_extraembryonic_tissu3.35072573
8MP0003866_abnormal_defecation3.20713624
9MP0005257_abnormal_intraocular_pressure2.84355804
10MP0000566_synostosis2.77570053
11MP0003300_gastrointestinal_ulcer2.77193607
12MP0008875_abnormal_xenobiotic_pharmacok2.75599654
13MP0004043_abnormal_pH_regulation2.74541298
14MP0005310_abnormal_salivary_gland2.73437690
15MP0001663_abnormal_digestive_system2.56832066
16MP0000537_abnormal_urethra_morphology2.56471887
17MP0010155_abnormal_intestine_physiology2.48728666
18MP0000678_abnormal_parathyroid_gland2.43122658
19MP0005381_digestive/alimentary_phenotyp2.40139875
20MP0000462_abnormal_digestive_system2.38573162
21MP0000490_abnormal_crypts_of2.30236585
22MP0001765_abnormal_ion_homeostasis2.25684493
23MP0001666_abnormal_nutrient_absorption2.21059467
24MP0002166_altered_tumor_susceptibility2.12676240
25MP0009379_abnormal_foot_pigmentation2.10187023
26MP0001984_abnormal_olfaction2.07899191
27MP0008789_abnormal_olfactory_epithelium2.05310084
28MP0003941_abnormal_skin_development1.99842691
29MP0001664_abnormal_digestion1.99699523
30MP0000477_abnormal_intestine_morphology1.96536053
31MP0005058_abnormal_lysosome_morphology1.95720564
32MP0005167_abnormal_blood-brain_barrier1.89604332
33MP0005623_abnormal_meninges_morphology1.89228666
34MP0004133_heterotaxia1.87678967
35MP0005083_abnormal_biliary_tract1.87279134
36MP0010678_abnormal_skin_adnexa1.83393177
37MP0002132_abnormal_respiratory_system1.78155150
38MP0003283_abnormal_digestive_organ1.70384810
39MP0010352_gastrointestinal_tract_polyps1.69580104
40MP0005165_increased_susceptibility_to1.66667233
41MP0002168_other_aberrant_phenotype1.65557030
42MP0002796_impaired_skin_barrier1.62662221
43MP0003191_abnormal_cellular_cholesterol1.60740876
44MP0005636_abnormal_mineral_homeostasis1.59957838
45MP0010386_abnormal_urinary_bladder1.56774113
46MP0001756_abnormal_urination1.56683023
47MP0002006_tumorigenesis1.56123715
48MP0009643_abnormal_urine_homeostasis1.52405977
49MP0000613_abnormal_salivary_gland1.50121586
50MP0005409_darkened_coat_color1.49450244
51MP0004885_abnormal_endolymph1.42402553
52MP0005085_abnormal_gallbladder_physiolo1.41496244
53MP0002139_abnormal_hepatobiliary_system1.36050956
54MP0004782_abnormal_surfactant_physiolog1.34867865
55MP0005166_decreased_susceptibility_to1.34188444
56MP0003303_peritoneal_inflammation1.32767632
57MP0002277_abnormal_respiratory_mucosa1.28851755
58MP0000470_abnormal_stomach_morphology1.25967426
59MP0000538_abnormal_urinary_bladder1.21148289
60MP0003656_abnormal_erythrocyte_physiolo1.19146898
61MP0005647_abnormal_sex_gland1.17163732
62MP0003868_abnormal_feces_composition1.16262975
63MP0005394_taste/olfaction_phenotype1.16071339
64MP0005499_abnormal_olfactory_system1.16071339
65MP0008004_abnormal_stomach_pH1.14099301
66MP0002009_preneoplasia1.13759002
67MP0002098_abnormal_vibrissa_morphology1.13530086
68MP0002282_abnormal_trachea_morphology1.12105889
69MP0003705_abnormal_hypodermis_morpholog1.11767788
70MP0002060_abnormal_skin_morphology1.09341329
71MP0003315_abnormal_perineum_morphology1.09191558
72MP0004185_abnormal_adipocyte_glucose1.07750355
73MP0000681_abnormal_thyroid_gland1.06400729
74MP0001346_abnormal_lacrimal_gland1.05500830
75MP0006054_spinal_hemorrhage1.05331525
76MP0005395_other_phenotype1.02980850
77MP0004019_abnormal_vitamin_homeostasis1.01084693
78MP0002249_abnormal_larynx_morphology1.00688220
79MP0003453_abnormal_keratinocyte_physiol0.98696996
80MP0005365_abnormal_bile_salt0.98209365
81MP0005360_urolithiasis0.96016170
82MP0000465_gastrointestinal_hemorrhage0.94385649
83MP0000858_altered_metastatic_potential0.94021172
84MP0004947_skin_inflammation0.92730976
85MP0002136_abnormal_kidney_physiology0.92632503
86MP0005248_abnormal_Harderian_gland0.91560053
87MP0002160_abnormal_reproductive_system0.91412472
88MP0001216_abnormal_epidermal_layer0.90232957
89MP0005164_abnormal_response_to0.88665370
90MP0003075_altered_response_to0.87053242
91MP0002234_abnormal_pharynx_morphology0.84545873
92MP0000762_abnormal_tongue_morphology0.83311182
93MP0009780_abnormal_chondrocyte_physiolo0.82067049
94MP0001849_ear_inflammation0.81270869
95MP0005501_abnormal_skin_physiology0.79005350
96MP0009384_cardiac_valve_regurgitation0.78832802
97MP0000383_abnormal_hair_follicle0.78566613
98MP0003045_fibrosis0.77399541
99MP0008872_abnormal_physiological_respon0.77189653
100MP0005408_hypopigmentation0.74320500
101MP0002909_abnormal_adrenal_gland0.71853323
102MP0006082_CNS_inflammation0.70820010
103MP0003566_abnormal_cell_adhesion0.70196916
104MP0005367_renal/urinary_system_phenotyp0.69496973
105MP0000516_abnormal_urinary_system0.69496973
106MP0004858_abnormal_nervous_system0.69444466
107MP0003183_abnormal_peptide_metabolism0.68352737
108MP0003252_abnormal_bile_duct0.67737797
109MP0002295_abnormal_pulmonary_circulatio0.67610265
110MP0008873_increased_physiological_sensi0.66884097
111MP0001485_abnormal_pinna_reflex0.66795208
112MP0004484_altered_response_of0.66641530
113MP0005076_abnormal_cell_differentiation0.64742850
114MP0009785_altered_susceptibility_to0.64566973
115MP0000467_abnormal_esophagus_morphology0.63327653
116MP0005387_immune_system_phenotype0.61709526
117MP0001790_abnormal_immune_system0.61709526
118MP0005319_abnormal_enzyme/_coenzyme0.61201526
119MP0005023_abnormal_wound_healing0.59920152
120MP0002876_abnormal_thyroid_physiology0.59791265
121MP0004883_abnormal_blood_vessel0.56874187
122MP0003806_abnormal_nucleotide_metabolis0.56558863
123MP0010771_integument_phenotype0.56379185
124MP0009764_decreased_sensitivity_to0.55534236
125MP0000579_abnormal_nail_morphology0.54463651
126MP0000013_abnormal_adipose_tissue0.52383663
127MP0001845_abnormal_inflammatory_respons0.52262544
128MP0001188_hyperpigmentation0.51595714
129MP0005275_abnormal_skin_tensile0.50396470
130MP0009765_abnormal_xenobiotic_induced0.49761036
131MP0002896_abnormal_bone_mineralization0.49128713
132MP0003879_abnormal_hair_cell0.48963798
133MP0000377_abnormal_hair_follicle0.48660260
134MP0005025_abnormal_response_to0.48645676
135MP0003950_abnormal_plasma_membrane0.47791388
136MP0000534_abnormal_ureter_morphology0.47545332
137MP0005220_abnormal_exocrine_pancreas0.47539651
138MP0002233_abnormal_nose_morphology0.47222474
139MP0000249_abnormal_blood_vessel0.46440996
140MP0005187_abnormal_penis_morphology0.46015016
141MP0002118_abnormal_lipid_homeostasis0.45831456
142MP0003186_abnormal_redox_activity0.44905729

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.75782139
2Bronchiectasis (HP:0002110)7.31901596
3Nasal polyposis (HP:0100582)6.84356802
4Hyperactive renin-angiotensin system (HP:0000841)6.50806273
5Pustule (HP:0200039)6.33478727
6Right ventricular cardiomyopathy (HP:0011663)6.20664600
7Abnormality of the nasal mucosa (HP:0000433)5.88645524
8Flat acetabular roof (HP:0003180)5.68368063
9Metabolic alkalosis (HP:0200114)5.26378411
10Abnormality of chloride homeostasis (HP:0011422)4.97539474
11Malnutrition (HP:0004395)4.83593833
12Abnormality of cochlea (HP:0000375)4.62868562
13Bronchitis (HP:0012387)4.50207909
14Recurrent sinusitis (HP:0011108)4.27991239
15Abnormal tarsal ossification (HP:0008369)4.24977734
16Infertility (HP:0000789)4.07077771
17Prostate neoplasm (HP:0100787)4.03611475
18Abnormality of the 1st metacarpal (HP:0010009)3.95464096
19Chronic sinusitis (HP:0011109)3.95404712
20Abnormality of small intestinal villus morphology (HP:0011472)3.92996958
21Villous atrophy (HP:0011473)3.92996958
22Alopecia of scalp (HP:0002293)3.88605560
23Vacuolated lymphocytes (HP:0001922)3.84011966
24Recurrent otitis media (HP:0000403)3.79561838
25Abdominal distention (HP:0003270)3.72448518
26Ileus (HP:0002595)3.68108916
27Abnormality of renin-angiotensin system (HP:0000847)3.65962184
28Hyperaldosteronism (HP:0000859)3.60844741
29Abnormal foot bone ossification (HP:0010675)3.36635739
30Onycholysis (HP:0001806)3.36341039
31Chronic otitis media (HP:0000389)3.10895941
32Occipital encephalocele (HP:0002085)3.10770288
33Morphological abnormality of the inner ear (HP:0011390)3.06690460
34Abnormality of the distal phalanx of the thumb (HP:0009617)3.05337892
35Woolly hair (HP:0002224)3.04499353
36Abnormality of the 2nd finger (HP:0004100)3.01578863
37Symphalangism affecting the phalanges of the hand (HP:0009773)2.99737483
38Fragile nails (HP:0001808)2.96840658
39Atelectasis (HP:0100750)2.95457377
40Pili torti (HP:0003777)2.93489471
41Abnormality of carpal bone ossification (HP:0006257)2.92333582
42Dehydration (HP:0001944)2.88156615
43Oligomenorrhea (HP:0000876)2.87573046
44Decreased circulating renin level (HP:0003351)2.81558694
45Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.81515048
46Short 1st metacarpal (HP:0010034)2.81515048
47Milia (HP:0001056)2.80560249
48Hypokalemia (HP:0002900)2.76961916
49Alkalosis (HP:0001948)2.67232370
50Aortic aneurysm (HP:0004942)2.65231896
51True hermaphroditism (HP:0010459)2.64510136
52Pancreatic fibrosis (HP:0100732)2.62562948
53Short phalanx of the thumb (HP:0009660)2.57389231
54Cheilitis (HP:0100825)2.55556988
55Flattened epiphyses (HP:0003071)2.52358250
56Micronodular cirrhosis (HP:0001413)2.48500426
57Shawl scrotum (HP:0000049)2.48346229
58Biliary tract neoplasm (HP:0100574)2.46429832
59Rectal prolapse (HP:0002035)2.45214434
60Short hallux (HP:0010109)2.40158084
61Atrophic scars (HP:0001075)2.37430236
62Cystic liver disease (HP:0006706)2.36038235
63Plantar hyperkeratosis (HP:0007556)2.35000369
64Hyperkalemia (HP:0002153)2.32701003
65Palpitations (HP:0001962)2.30984006
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.29882832
67Hyponatremia (HP:0002902)2.29606702
68Abnormal ossification of hand bones (HP:0005921)2.27242608
69Abnormality of the distal phalanges of the toes (HP:0010182)2.27152389
70Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.18493123
71Aplasia/Hypoplasia of the hallux (HP:0008362)2.17223953
72Abnormal hand bone ossification (HP:0010660)2.15667873
73Mildly elevated creatine phosphokinase (HP:0008180)2.15062807
74Microretrognathia (HP:0000308)2.14823418
75Ventricular tachycardia (HP:0004756)2.14428682
76Dysostosis multiplex (HP:0000943)2.13206090
77Renal salt wasting (HP:0000127)2.10538036
78Abnormality of the middle phalanges of the toes (HP:0010183)2.10246761
79Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.09855449
80Chronic diarrhea (HP:0002028)2.09642574
81Cupped ribs (HP:0000887)2.08693080
82Abnormality of potassium homeostasis (HP:0011042)2.08400780
83Widely patent fontanelles and sutures (HP:0004492)2.08349388
84Abnormal biliary tract morphology (HP:0012440)2.06953902
85Neonatal short-limb short stature (HP:0008921)2.06110266
86Molar tooth sign on MRI (HP:0002419)2.02540706
87Abnormality of midbrain morphology (HP:0002418)2.02540706
88Tubulointerstitial nephritis (HP:0001970)2.01589413
89Pancreatic cysts (HP:0001737)2.01272115
90Abnormality of magnesium homeostasis (HP:0004921)2.01148812
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9738039
92Abnormal respiratory epithelium morphology (HP:0012253)10.5845359
93Abnormal respiratory motile cilium morphology (HP:0005938)10.5845359
94Abnormal respiratory motile cilium physiology (HP:0012261)10.4240950
95Absent/shortened dynein arms (HP:0200106)10.1844477
96Dynein arm defect of respiratory motile cilia (HP:0012255)10.1844477
97Abnormal ciliary motility (HP:0012262)10.0957545
98Petechiae (HP:0000967)1.99921992
99Hypomagnesemia (HP:0002917)1.99855894
100Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99459113
101Congenital, generalized hypertrichosis (HP:0004540)1.98176919
102Nephronophthisis (HP:0000090)1.96197820
103Recurrent bronchitis (HP:0002837)1.94833394
104Aplasia/hypoplasia of the femur (HP:0005613)1.94812221
105Abnormality of fatty-acid metabolism (HP:0004359)1.94482549
106Chronic bronchitis (HP:0004469)1.94356722
107Bell-shaped thorax (HP:0001591)1.94224920
108Cone-rod dystrophy (HP:0000548)1.93759890
109Curly hair (HP:0002212)1.92977627
110Abnormal vertebral ossification (HP:0100569)1.91663716
111Ureteral stenosis (HP:0000071)1.91497982
112Abnormal cartilage morphology (HP:0002763)1.89029199
113Chronic hepatic failure (HP:0100626)1.88324896
114Postaxial foot polydactyly (HP:0001830)1.88166837
115Ureteral obstruction (HP:0006000)1.88083844
116Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86576376
117Vertebral hypoplasia (HP:0008417)1.86576376
118Hypokalemic alkalosis (HP:0001949)1.85913843
119Beaking of vertebral bodies (HP:0004568)1.85715264
120Hyperparathyroidism (HP:0000843)1.84630004
121Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82372376
122Abnormality of sodium homeostasis (HP:0010931)1.82147846
123Hoarse voice (HP:0001609)1.81784428
124Aortic dissection (HP:0002647)1.78016716
125Gastrointestinal dysmotility (HP:0002579)1.77606250
126Adrenal overactivity (HP:0002717)1.75120913
127Esophageal varix (HP:0002040)1.73791380
128Potter facies (HP:0002009)1.73742250
129Facial shape deformation (HP:0011334)1.73742250
130Myopathic facies (HP:0002058)1.72344522
131Tracheal stenosis (HP:0002777)1.70392077
132Proximal tubulopathy (HP:0000114)1.70125480
133Male infertility (HP:0003251)1.69605046
134Absent frontal sinuses (HP:0002688)1.63321039
135Abnormality of the renal medulla (HP:0100957)1.58914077
136Congenital hepatic fibrosis (HP:0002612)1.58434274
137Nephropathy (HP:0000112)1.52188395
138Male pseudohermaphroditism (HP:0000037)1.52172941
139Spinal cord compression (HP:0002176)1.49054570
140Tubular atrophy (HP:0000092)1.48327602
141Anencephaly (HP:0002323)1.42736280
142Furrowed tongue (HP:0000221)1.41456238
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.41333471
144Vascular calcification (HP:0004934)1.40799038
145Popliteal pterygium (HP:0009756)1.39976379
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.39918824
147Asplenia (HP:0001746)1.39628362
148Hand muscle atrophy (HP:0009130)1.39356864
149Abnormality of the dental root (HP:0006486)1.38518929
150Taurodontia (HP:0000679)1.38518929
151Abnormality of permanent molar morphology (HP:0011071)1.38518929
152Short nail (HP:0001799)1.38086039
153Glucose intolerance (HP:0000833)1.35753424
154Short thorax (HP:0010306)1.32247742
155Hypotension (HP:0002615)1.30400361
156Lip pit (HP:0100267)1.28251076
157Abnormality of molar (HP:0011077)1.27187858
158Abnormality of molar morphology (HP:0011070)1.27187858
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.24664201
160Bifid scrotum (HP:0000048)1.24428234
161Oculomotor apraxia (HP:0000657)1.23598138
162Abnormality of the dental pulp (HP:0006479)1.22178747
163Upper limb amyotrophy (HP:0009129)1.21406268
164Distal upper limb amyotrophy (HP:0007149)1.21406268
165Cardiovascular calcification (HP:0011915)1.20838073
166Medial flaring of the eyebrow (HP:0010747)1.19210914
167Congenital primary aphakia (HP:0007707)1.15364226
168Distal lower limb muscle weakness (HP:0009053)1.14847584
169Short femoral neck (HP:0100864)1.14794473
170Sclerocornea (HP:0000647)1.14019003
171Ventricular fibrillation (HP:0001663)1.12569578
172Fat malabsorption (HP:0002630)1.11209828
173Hemorrhage of the eye (HP:0011885)1.10157046
174Gait imbalance (HP:0002141)1.09372676
175Stridor (HP:0010307)1.09168788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.82667441
2MST1R7.75482605
3PIK3CA7.08779936
4MAP3K24.14014445
5FRK3.57816390
6MST43.51783026
7LMTK23.20400066
8KSR23.08828837
9MAP2K22.91299262
10MET2.90493258
11AKT32.89371915
12TAOK32.88713350
13SMG12.34903514
14STK242.24162087
15MYLK2.18236591
16STK392.09503582
17NME11.95961921
18EEF2K1.80330266
19EPHA21.74634120
20TESK11.64043731
21MAP2K11.50019189
22PRKG21.42741583
23ACVR1B1.38531741
24EPHB21.36811380
25MAP3K121.35010011
26OXSR11.27496590
27EPHA31.13397930
28ERN11.12588387
29LATS11.10302250
30CAMK2D1.08916715
31RPS6KB21.08270505
32NEK61.06170002
33PDK21.01052074
34BCR0.99691083
35PTK2B0.96159892
36TBK10.94714724
37FER0.94184393
38NUAK10.91345515
39BCKDK0.88492670
40DMPK0.87447187
41MAPKAPK30.85835167
42PTK60.80060102
43MAP3K80.78935459
44STK380.75860281
45MAPKAPK50.74291024
46ICK0.73098545
47LRRK20.70867700
48TRPM70.70770545
49TTN0.70447455
50PIK3CG0.69721682
51MAP3K10.67895457
52DDR20.67704065
53PRKCI0.67589876
54MARK20.64973922
55STK100.62818157
56LIMK10.60833589
57RIPK10.56731463
58TAOK10.54090766
59ERBB30.53692923
60SCYL20.53414827
61FGFR30.52525439
62MATK0.51492245
63FGFR40.50923082
64WNK40.50727672
65TESK20.50582262
66SIK10.49146514
67WNK10.48263383
68PRKCD0.46160665
69TYK20.46003498
70PTK20.45728318
71RET0.45123318
72ZAP700.42437479
73IRAK10.41941459
74PBK0.41465922
75NLK0.40327654
76CAMKK10.39623038
77HIPK20.39342738
78CDK30.38969830
79ABL20.37530422
80ROCK10.37447504
81TLK10.37352563
82ERBB20.35876366
83JAK20.35098164
84PRKCQ0.32042167
85CDK90.31666354
86TRIB30.30377798
87CAMK2G0.28959130
88AURKB0.28479325
89PIM20.28272932
90DYRK1B0.28227626
91SGK10.28124579
92PDPK10.27695579
93PAK20.27440914
94BRSK20.26836764
95PNCK0.26081007
96ROCK20.25627233
97DAPK30.25278184
98CAMK2B0.24663511
99MAP2K60.23263773
100EPHB10.22957075
101GRK10.22405651
102TTK0.21361317
103MAP3K30.20683769
104CDK60.20402925
105GRK60.19919487
106PAK40.19797064
107SRC0.19088676
108PAK10.18932911
109CSK0.18929899
110FYN0.18466343
111FGFR20.18336906
112RPS6KA20.17894255
113PRKCA0.17632648
114ARAF0.17317826
115ILK0.17221444
116MAP3K70.15681697
117CDC42BPA0.15010523
118PKN20.14106503
119BMPR20.13949039
120ABL10.13610972
121IGF1R0.13498962
122MAP3K100.13426152
123YES10.13325124
124AKT20.11390435
125PDK10.11200124
126PRKD20.11077098
127PRKAA20.10341552
128MELK0.10184467
129PRKAA10.08925816
130SGK30.08484548
131TNK20.08052203
132PDGFRA0.07800665
133PDGFRB0.07716782
134RIPK40.07689296
135STK38L0.07167076
136RPS6KA10.06369305
137PAK30.05901876
138STK30.05853909
139ADRBK10.05814064
140MAPKAPK20.05158244
141PHKG20.04353383
142PHKG10.04353383
143CAMK1D0.04057764

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009207.75675437
2Mineral absorption_Homo sapiens_hsa049784.05015401
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.47095336
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.77887346
5Caffeine metabolism_Homo sapiens_hsa002322.53226802
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25875754
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.22502287
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.21577912
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08460107
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.00780344
11Bile secretion_Homo sapiens_hsa049761.90226711
12Tight junction_Homo sapiens_hsa045301.78753402
13Sulfur relay system_Homo sapiens_hsa041221.70570915
14Other glycan degradation_Homo sapiens_hsa005111.63682719
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61441084
16Thyroid cancer_Homo sapiens_hsa052161.54946764
17Histidine metabolism_Homo sapiens_hsa003401.53420565
18Fructose and mannose metabolism_Homo sapiens_hsa000511.52063144
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47087483
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46213943
21Salivary secretion_Homo sapiens_hsa049701.45213273
22Bladder cancer_Homo sapiens_hsa052191.38952383
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36943481
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34932336
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.34440142
26Huntingtons disease_Homo sapiens_hsa050161.30873640
27Pancreatic secretion_Homo sapiens_hsa049721.27969295
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25203237
29Butanoate metabolism_Homo sapiens_hsa006501.22912905
30Renin-angiotensin system_Homo sapiens_hsa046141.20966271
31Oxidative phosphorylation_Homo sapiens_hsa001901.20265258
32Vibrio cholerae infection_Homo sapiens_hsa051101.20122098
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18732802
34Adherens junction_Homo sapiens_hsa045201.16558782
35Chemical carcinogenesis_Homo sapiens_hsa052041.14475101
36Arginine biosynthesis_Homo sapiens_hsa002201.13512461
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10782190
38Nitrogen metabolism_Homo sapiens_hsa009101.09450098
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.06878066
40Hepatitis C_Homo sapiens_hsa051601.00680140
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96464840
42Fatty acid degradation_Homo sapiens_hsa000710.95037147
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94776907
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94709038
45N-Glycan biosynthesis_Homo sapiens_hsa005100.94282851
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92907689
47Alzheimers disease_Homo sapiens_hsa050100.92602681
48Tryptophan metabolism_Homo sapiens_hsa003800.91793435
49Peroxisome_Homo sapiens_hsa041460.90298638
50Gastric acid secretion_Homo sapiens_hsa049710.87651568
51Thyroid hormone synthesis_Homo sapiens_hsa049180.83897279
52Glycerolipid metabolism_Homo sapiens_hsa005610.83785326
53ABC transporters_Homo sapiens_hsa020100.82886362
54Vitamin digestion and absorption_Homo sapiens_hsa049770.81525471
55Glutathione metabolism_Homo sapiens_hsa004800.80595152
56Fat digestion and absorption_Homo sapiens_hsa049750.76869584
57Salmonella infection_Homo sapiens_hsa051320.74739032
58Endometrial cancer_Homo sapiens_hsa052130.73607667
59Protein digestion and absorption_Homo sapiens_hsa049740.73284052
60Galactose metabolism_Homo sapiens_hsa000520.71463321
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68817853
62Folate biosynthesis_Homo sapiens_hsa007900.68053236
63Propanoate metabolism_Homo sapiens_hsa006400.63376872
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63124534
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63009445
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62412458
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62232545
68Phenylalanine metabolism_Homo sapiens_hsa003600.62179967
69African trypanosomiasis_Homo sapiens_hsa051430.61682776
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60423946
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55765397
72Amoebiasis_Homo sapiens_hsa051460.52666073
73Sphingolipid metabolism_Homo sapiens_hsa006000.51363142
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51237266
75Dorso-ventral axis formation_Homo sapiens_hsa043200.50246450
76Parkinsons disease_Homo sapiens_hsa050120.49795616
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48879194
78beta-Alanine metabolism_Homo sapiens_hsa004100.48393634
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.47934350
80PPAR signaling pathway_Homo sapiens_hsa033200.46908938
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46816600
82Prostate cancer_Homo sapiens_hsa052150.45347642
83ECM-receptor interaction_Homo sapiens_hsa045120.44703312
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.43715752
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42213030
86Notch signaling pathway_Homo sapiens_hsa043300.41015791
87Focal adhesion_Homo sapiens_hsa045100.40580663
88Linoleic acid metabolism_Homo sapiens_hsa005910.40578062
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40532912
90Starch and sucrose metabolism_Homo sapiens_hsa005000.39873584
91Type I diabetes mellitus_Homo sapiens_hsa049400.38251467
92Tyrosine metabolism_Homo sapiens_hsa003500.37568232
93Arachidonic acid metabolism_Homo sapiens_hsa005900.37535928
94Gap junction_Homo sapiens_hsa045400.37425633
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.35645724
96Asthma_Homo sapiens_hsa053100.35370347
97Insulin resistance_Homo sapiens_hsa049310.34588778
98Autoimmune thyroid disease_Homo sapiens_hsa053200.33720850
99Allograft rejection_Homo sapiens_hsa053300.32743243
100Circadian rhythm_Homo sapiens_hsa047100.32021140
101Choline metabolism in cancer_Homo sapiens_hsa052310.31760179
102Cardiac muscle contraction_Homo sapiens_hsa042600.31703113
103Toxoplasmosis_Homo sapiens_hsa051450.31665925
104Fatty acid biosynthesis_Homo sapiens_hsa000610.31253854
105Collecting duct acid secretion_Homo sapiens_hsa049660.30308800
106Protein export_Homo sapiens_hsa030600.29884252
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27377540
108Metabolic pathways_Homo sapiens_hsa011000.27303443
109Complement and coagulation cascades_Homo sapiens_hsa046100.26017497
110Hematopoietic cell lineage_Homo sapiens_hsa046400.25127137
111Arginine and proline metabolism_Homo sapiens_hsa003300.25086542
112Pentose phosphate pathway_Homo sapiens_hsa000300.24783432
113Graft-versus-host disease_Homo sapiens_hsa053320.24613131
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.24327076
115Influenza A_Homo sapiens_hsa051640.24089473
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.23962163
117Inositol phosphate metabolism_Homo sapiens_hsa005620.23910463
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.22634940
119Chronic myeloid leukemia_Homo sapiens_hsa052200.22467111
120Retinol metabolism_Homo sapiens_hsa008300.21864070
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20948864
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.20744801
123HIF-1 signaling pathway_Homo sapiens_hsa040660.20260499
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19916293
125Pyruvate metabolism_Homo sapiens_hsa006200.19373447
126Lysosome_Homo sapiens_hsa041420.19236685
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18513775
128Antigen processing and presentation_Homo sapiens_hsa046120.16040448
129Endocytosis_Homo sapiens_hsa041440.15982205
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14452609
131Staphylococcus aureus infection_Homo sapiens_hsa051500.12814211
132Renin secretion_Homo sapiens_hsa049240.11836139
133Taste transduction_Homo sapiens_hsa047420.11723122
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.11599078

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