TSPAN10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1developmental pigmentation (GO:0048066)9.96783885
2phenol-containing compound biosynthetic process (GO:0046189)9.18169581
3secondary metabolic process (GO:0019748)8.81273492
4ketone body metabolic process (GO:1902224)7.18404930
5pigment biosynthetic process (GO:0046148)7.12517468
6melanocyte differentiation (GO:0030318)7.00066037
7proline biosynthetic process (GO:0006561)6.36656263
8pigment cell differentiation (GO:0050931)6.36221052
9behavioral response to nicotine (GO:0035095)5.49718028
10pigment metabolic process (GO:0042440)5.41225277
11melanosome organization (GO:0032438)5.33008579
12mitotic G1 DNA damage checkpoint (GO:0031571)5.20573579
13negative regulation of hydrogen peroxide-induced cell death (GO:1903206)5.17927340
14pigment granule organization (GO:0048753)5.02193077
15regulation of hydrogen peroxide-induced cell death (GO:1903205)4.82216395
16proline metabolic process (GO:0006560)4.70072915
17negative regulation of response to reactive oxygen species (GO:1901032)4.67223813
18G1 DNA damage checkpoint (GO:0044783)4.56267731
19mitotic G1/S transition checkpoint (GO:0044819)4.54320639
20L-fucose catabolic process (GO:0042355)4.51065811
21fucose catabolic process (GO:0019317)4.51065811
22L-fucose metabolic process (GO:0042354)4.51065811
23regulation of endothelial cell chemotaxis (GO:2001026)4.38278526
24oxidative demethylation (GO:0070989)4.35616633
25neuroepithelial cell differentiation (GO:0060563)4.35322284
26embryonic process involved in female pregnancy (GO:0060136)4.34495509
27negative regulation of fatty acid biosynthetic process (GO:0045717)4.18166457
28indolalkylamine metabolic process (GO:0006586)4.15930524
29transcription from mitochondrial promoter (GO:0006390)4.12232174
30tryptophan catabolic process (GO:0006569)4.09616777
31indole-containing compound catabolic process (GO:0042436)4.09616777
32indolalkylamine catabolic process (GO:0046218)4.09616777
33kynurenine metabolic process (GO:0070189)3.98029182
34kidney morphogenesis (GO:0060993)3.91190139
35pigmentation (GO:0043473)3.88564433
36dosage compensation (GO:0007549)3.87287184
37replication fork processing (GO:0031297)3.82167213
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.81826137
39tryptophan metabolic process (GO:0006568)3.80896815
40detection of light stimulus involved in visual perception (GO:0050908)3.80223961
41detection of light stimulus involved in sensory perception (GO:0050962)3.80223961
42myotube differentiation (GO:0014902)3.78645768
43negative regulation of telomere maintenance (GO:0032205)3.76376978
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73562010
45regulation of integrin activation (GO:0033623)3.70867853
46positive regulation of neuroblast proliferation (GO:0002052)3.67244376
47pseudouridine synthesis (GO:0001522)3.63792448
48piRNA metabolic process (GO:0034587)3.58716667
49mesenchymal-epithelial cell signaling (GO:0060638)3.57393032
50response to pheromone (GO:0019236)3.56303069
51aromatic amino acid family metabolic process (GO:0009072)3.54249534
52regulation of response to reactive oxygen species (GO:1901031)3.53897767
53regulation of translational fidelity (GO:0006450)3.53727106
54positive regulation of protein homooligomerization (GO:0032464)3.47855475
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34465627
56phenol-containing compound metabolic process (GO:0018958)3.34324059
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32422930
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.32422930
59NADH dehydrogenase complex assembly (GO:0010257)3.32422930
60short-chain fatty acid metabolic process (GO:0046459)3.30620570
61cellular ketone body metabolic process (GO:0046950)3.30286460
62mitochondrial DNA metabolic process (GO:0032042)3.25979895
63cornea development in camera-type eye (GO:0061303)3.22872294
64establishment of apical/basal cell polarity (GO:0035089)3.21629279
65sulfation (GO:0051923)3.20615030
66regulation of hippo signaling (GO:0035330)3.18881378
67protein complex biogenesis (GO:0070271)3.18527465
68preassembly of GPI anchor in ER membrane (GO:0016254)3.15737042
69regulation of protein homooligomerization (GO:0032462)3.14550817
70regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.11973743
71indole-containing compound metabolic process (GO:0042430)3.10692007
72endothelial cell morphogenesis (GO:0001886)3.08805057
73protein polyglutamylation (GO:0018095)3.08513237
74cytidine deamination (GO:0009972)3.08013208
75cytidine metabolic process (GO:0046087)3.08013208
76cytidine catabolic process (GO:0006216)3.08013208
77water-soluble vitamin biosynthetic process (GO:0042364)3.07989965
78melanin biosynthetic process (GO:0042438)27.9530192
79melanin metabolic process (GO:0006582)25.3080929
80secondary metabolite biosynthetic process (GO:0044550)23.1867501
81epithelial cilium movement (GO:0003351)2.99794533
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97377230
83DNA methylation involved in gamete generation (GO:0043046)2.96928153
84primary amino compound metabolic process (GO:1901160)2.94488759
85mitochondrial respiratory chain complex assembly (GO:0033108)2.93714225
86atrial cardiac muscle cell action potential (GO:0086014)2.91997328
87mannosylation (GO:0097502)2.90878556
88platelet dense granule organization (GO:0060155)2.90470455
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.90386763
90regulation of early endosome to late endosome transport (GO:2000641)2.88768215
91amine catabolic process (GO:0009310)2.85534516
92cellular biogenic amine catabolic process (GO:0042402)2.85534516
93vitamin A metabolic process (GO:0006776)2.83347452
94axoneme assembly (GO:0035082)2.82111819
95respiratory chain complex IV assembly (GO:0008535)2.81256686
96labyrinthine layer development (GO:0060711)2.80521754
97neural tube formation (GO:0001841)2.80447790
98somatic stem cell division (GO:0048103)2.80442635
99negative regulation of JAK-STAT cascade (GO:0046426)2.80394107
100negative regulation of fatty acid metabolic process (GO:0045922)2.79478890
101multicellular organism reproduction (GO:0032504)2.79408813
102negative regulation of interleukin-1 beta production (GO:0032691)2.79158842
103establishment or maintenance of monopolar cell polarity (GO:0061339)2.75916543
104establishment of monopolar cell polarity (GO:0061162)2.75916543
105embryonic placenta development (GO:0001892)2.72899774
106peristalsis (GO:0030432)2.72893570
107pyrimidine ribonucleoside catabolic process (GO:0046133)2.72760830
108ubiquinone biosynthetic process (GO:0006744)2.72007164
109regulation of cAMP-dependent protein kinase activity (GO:2000479)2.71916038
110nerve growth factor signaling pathway (GO:0038180)2.71386726
111negative regulation of mast cell activation (GO:0033004)2.70551652
112mRNA cleavage (GO:0006379)2.70499784
113regulation of mesoderm development (GO:2000380)2.68975968
114serotonin metabolic process (GO:0042428)2.67834111
115protein K11-linked deubiquitination (GO:0035871)2.66733364
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66371372
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66371372
118nonmotile primary cilium assembly (GO:0035058)2.66325704
119cellular response to ATP (GO:0071318)2.65535127
120L-methionine salvage (GO:0071267)2.64919019
121L-methionine biosynthetic process (GO:0071265)2.64919019
122amino acid salvage (GO:0043102)2.64919019
123endosome to pigment granule transport (GO:0043485)2.64662437
124endosome to melanosome transport (GO:0035646)2.64662437
125glutamine family amino acid biosynthetic process (GO:0009084)2.64452948
126reflex (GO:0060004)2.64017125
127rhodopsin mediated signaling pathway (GO:0016056)2.63891776
128columnar/cuboidal epithelial cell differentiation (GO:0002065)2.63480029
129regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63402772
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.63265019
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63265019
132auditory receptor cell stereocilium organization (GO:0060088)2.63175339
133regulation of neuroblast proliferation (GO:1902692)2.62534864
134phasic smooth muscle contraction (GO:0014821)2.59012516
135positive regulation of defense response to virus by host (GO:0002230)2.58445553
136negative regulation of oxidative stress-induced cell death (GO:1903202)2.57704161
137positive regulation of sodium ion transmembrane transport (GO:1902307)2.57393218
138negative regulation of interleukin-1 production (GO:0032692)2.57088067
139gamma-aminobutyric acid transport (GO:0015812)2.56986475
140cytochrome complex assembly (GO:0017004)2.56078392
141negative regulation of systemic arterial blood pressure (GO:0003085)2.55664642
142neuronal action potential (GO:0019228)2.55657783
143ubiquinone metabolic process (GO:0006743)2.55204331
144reciprocal meiotic recombination (GO:0007131)2.54583221
145reciprocal DNA recombination (GO:0035825)2.54583221
146negative regulation of reactive oxygen species metabolic process (GO:2000378)2.54559397
147urinary tract smooth muscle contraction (GO:0014848)2.54159030
148DNA demethylation (GO:0080111)2.53770575
149cilium morphogenesis (GO:0060271)2.52713311
150positive regulation of guanylate cyclase activity (GO:0031284)2.52625521
151arginine catabolic process (GO:0006527)2.52161062
152nephron epithelium morphogenesis (GO:0072088)2.52011393
153nephron tubule morphogenesis (GO:0072078)2.52011393
154regulation of microtubule-based movement (GO:0060632)2.51779997
155regulation of cilium movement (GO:0003352)2.51527299
156regulation of action potential (GO:0098900)2.49719909
157rRNA catabolic process (GO:0016075)2.48590720
158cilium movement (GO:0003341)2.47937723
159glycerophospholipid catabolic process (GO:0046475)2.47514081
160negative regulation of response to oxidative stress (GO:1902883)2.46261252
161negative regulation of cellular response to oxidative stress (GO:1900408)2.46261252
162DNA deamination (GO:0045006)2.44985129
163DNA strand renaturation (GO:0000733)2.44776772
164spliceosomal tri-snRNP complex assembly (GO:0000244)2.41754776
165establishment of protein localization to mitochondrial membrane (GO:0090151)2.41141430
166semaphorin-plexin signaling pathway (GO:0071526)2.41055805
167formation of translation preinitiation complex (GO:0001731)2.41051099
168cellular response to zinc ion (GO:0071294)2.37639958
169regulation of sister chromatid cohesion (GO:0007063)2.37296246
170negative regulation of protein oligomerization (GO:0032460)2.34888888
171muscle cell migration (GO:0014812)2.34031242
172N-glycan processing (GO:0006491)2.33653236
173negative regulation of cell cycle arrest (GO:0071157)2.29944637
174embryonic camera-type eye development (GO:0031076)2.29800014
175bone remodeling (GO:0046849)2.29296142
176DNA integration (GO:0015074)2.26898818
177protein localization to endosome (GO:0036010)2.25386590
178poly(A)+ mRNA export from nucleus (GO:0016973)2.25130574
179negative regulation of Ras GTPase activity (GO:0034261)2.23349010
1804-hydroxyproline metabolic process (GO:0019471)2.21531313
181negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.20344459
182viral mRNA export from host cell nucleus (GO:0046784)2.17926475
183regulation of RNA export from nucleus (GO:0046831)2.17682755
184negative regulation of adherens junction organization (GO:1903392)2.14674621
185negative regulation of focal adhesion assembly (GO:0051895)2.14674621
186negative regulation of cell junction assembly (GO:1901889)2.14674621
187positive regulation of developmental pigmentation (GO:0048087)2.12716821
188regulation of response to oxidative stress (GO:1902882)2.08647864
189regulation of oxidative stress-induced cell death (GO:1903201)2.07509139
190regulation of somitogenesis (GO:0014807)2.06905322
191double-strand break repair via nonhomologous end joining (GO:0006303)2.04025936
192non-recombinational repair (GO:0000726)2.04025936
193regulation of protein oligomerization (GO:0032459)2.03917534
194tyrosine metabolic process (GO:0006570)11.3946002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.49435554
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.70451456
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.35387069
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.27229219
5VDR_22108803_ChIP-Seq_LS180_Human3.22438488
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15646382
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94520963
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87477723
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70111997
10GBX2_23144817_ChIP-Seq_PC3_Human2.65951912
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59166433
12EZH2_22144423_ChIP-Seq_EOC_Human2.55383221
13E2F7_22180533_ChIP-Seq_HELA_Human2.54320379
14VDR_21846776_ChIP-Seq_THP-1_Human2.51149385
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50584761
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48968571
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.46163740
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43589832
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.32919119
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31437026
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31437026
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31437026
23POU5F1_16518401_ChIP-PET_MESCs_Mouse2.27765945
24ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25188582
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.21818236
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18139557
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14415049
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10198789
29IGF1R_20145208_ChIP-Seq_DFB_Human2.09796870
30KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.07201889
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.06695656
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01959029
33LXR_22292898_ChIP-Seq_THP-1_Human2.01860711
34ZNF263_19887448_ChIP-Seq_K562_Human1.95743776
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94229897
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93980582
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93384747
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92625097
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.90849963
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89876065
41ER_23166858_ChIP-Seq_MCF-7_Human1.89563396
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88673805
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88382607
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86124390
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85080437
46TFEB_21752829_ChIP-Seq_HELA_Human1.82759269
47IRF1_19129219_ChIP-ChIP_H3396_Human1.82077731
48FUS_26573619_Chip-Seq_HEK293_Human1.81044085
49P300_19829295_ChIP-Seq_ESCs_Human1.80911733
50EWS_26573619_Chip-Seq_HEK293_Human1.80672383
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77669185
52PU.1_20513432_ChIP-Seq_Bcells_Mouse1.77328900
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72865074
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72614294
55TP53_22573176_ChIP-Seq_HFKS_Human1.65809305
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.65555538
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62112798
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.61303521
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61184274
60RACK7_27058665_Chip-Seq_MCF-7_Human1.60785148
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58028931
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.56850505
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56205489
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.52986069
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52860769
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51695302
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50987128
68STAT3_23295773_ChIP-Seq_U87_Human1.49956889
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49035863
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48179583
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48021618
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47702290
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.46987694
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46819262
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46819262
76TCF4_23295773_ChIP-Seq_U87_Human1.45722847
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.45522712
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.45420435
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45420435
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45338111
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.44296875
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.43815647
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.42677401
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42342508
85MYC_18940864_ChIP-ChIP_HL60_Human1.41893946
86AR_21572438_ChIP-Seq_LNCaP_Human1.40381538
87AR_25329375_ChIP-Seq_VCAP_Human1.39347392
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38640360
89REST_21632747_ChIP-Seq_MESCs_Mouse1.38273696
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36896372
91BCAT_22108803_ChIP-Seq_LS180_Human1.36612228
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.35356464
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.35259086
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34859617
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34822166
96TAF15_26573619_Chip-Seq_HEK293_Human1.34486169
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34366947
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34189374
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33562396
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32966346
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32620706
102* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32531717
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32069639
104SMAD4_21799915_ChIP-Seq_A2780_Human1.31945244
105SOX2_19829295_ChIP-Seq_ESCs_Human1.31903614
106NANOG_19829295_ChIP-Seq_ESCs_Human1.31903614
107HOXB7_26014856_ChIP-Seq_BT474_Human1.31110694
108CBP_20019798_ChIP-Seq_JUKART_Human1.30745566
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30745566
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29831455
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29715559
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27887699
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27695116
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27694902
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27176893
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26885029
117MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26408874
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26377031
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25838229
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.25648097
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25643559
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.25504484
123AR_20517297_ChIP-Seq_VCAP_Human1.25479602
124KDM2B_26808549_Chip-Seq_DND41_Human1.24157956
125NCOR_22424771_ChIP-Seq_293T_Human1.24012104
126GATA1_22025678_ChIP-Seq_K562_Human1.23916340
127ERA_21632823_ChIP-Seq_H3396_Human1.23888030
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22770120
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22704610
130TCF4_22108803_ChIP-Seq_LS180_Human1.21942448
131SPI1_26923725_Chip-Seq_HPCs_Mouse1.21877963
132* MITF_21258399_ChIP-Seq_MELANOMA_Human1.21836982
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21398274
134ETS1_21867929_ChIP-Seq_TH2_Mouse1.20161327
135FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20059039
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19997754
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19545954
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19406422
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18928495
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18624843
141MYC_19829295_ChIP-Seq_ESCs_Human1.17855895
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17844280
143SMAD3_21741376_ChIP-Seq_EPCs_Human1.17557737
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17388492
145SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17184887
146RNF2_27304074_Chip-Seq_NSC_Mouse1.16928787
147EST1_17652178_ChIP-ChIP_JURKAT_Human1.15694422
148MYC_22102868_ChIP-Seq_BL_Human1.14154941
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13920090
150E2F1_21310950_ChIP-Seq_MCF-7_Human1.12389394
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12323518
152PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12199587
153ELK3_25401928_ChIP-Seq_HUVEC_Human1.11974155
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11636790
155RUNX2_22187159_ChIP-Seq_PCA_Human1.10616034
156POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09518291
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09165810
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08503160
159TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08432904
160FLI1_21867929_ChIP-Seq_TH2_Mouse1.07570847
161RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07148248
162NANOG_20526341_ChIP-Seq_ESCs_Human1.06932780
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06217913
164SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05952528
165THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05696451
166NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05689109
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05654421
168NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05571733
169TP53_16413492_ChIP-PET_HCT116_Human1.04598823
170SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04453176
171IRF8_22096565_ChIP-ChIP_GC-B_Human1.04036872
172LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03281536
173PRDM14_20953172_ChIP-Seq_ESCs_Human1.03273154
174TRIM28_21343339_ChIP-Seq_HEK293_Human1.03131435
175ATF3_27146783_Chip-Seq_COLON_Human1.02364741
176FOXH1_21741376_ChIP-Seq_EPCs_Human1.02268554
177TAF2_19829295_ChIP-Seq_ESCs_Human1.01827305
178SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01274770
179KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00630735
180* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00537932
181SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00131843
182NFE2_27457419_Chip-Seq_LIVER_Mouse1.00126037
183SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00115228
184* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99478919
185KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99388506
186ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98863324
187TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98537936
188NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98509894
189EED_16625203_ChIP-ChIP_MESCs_Mouse0.97860778
190* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97712466
191TP53_23651856_ChIP-Seq_MEFs_Mouse0.97616911
192E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97469281
193EZH2_27294783_Chip-Seq_NPCs_Mouse0.97011410
194VDR_23849224_ChIP-Seq_CD4+_Human0.96977531
195POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96179773
196AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95289145
197CRX_20693478_ChIP-Seq_RETINA_Mouse0.94908113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation9.97470356
2MP0003136_yellow_coat_color5.24636885
3MP0005408_hypopigmentation5.06072992
4MP0000371_diluted_coat_color4.55202711
5MP0004147_increased_porphyrin_level3.60616375
6MP0004381_abnormal_hair_follicle3.57579482
7MP0000015_abnormal_ear_pigmentation3.46616755
8MP0005257_abnormal_intraocular_pressure3.42800525
9MP0002877_abnormal_melanocyte_morpholog3.10576472
10MP0003646_muscle_fatigue3.09907522
11MP0002095_abnormal_skin_pigmentation3.03237293
12MP0003195_calcinosis2.95201813
13MP0001324_abnormal_eye_pigmentation2.84987144
14MP0005377_hearing/vestibular/ear_phenot2.70162334
15MP0003878_abnormal_ear_physiology2.70162334
16MP0005075_abnormal_melanosome_morpholog2.66910802
17MP0002075_abnormal_coat/hair_pigmentati2.61719416
18MP0005174_abnormal_tail_pigmentation2.54090796
19MP0008872_abnormal_physiological_respon2.32123256
20MP0004043_abnormal_pH_regulation2.29274615
21MP0002837_dystrophic_cardiac_calcinosis2.11894394
22MP0001186_pigmentation_phenotype2.11311504
23MP0002102_abnormal_ear_morphology2.09988083
24MP0008877_abnormal_DNA_methylation2.01504570
25MP0000372_irregular_coat_pigmentation10.1164452
26MP0001968_abnormal_touch/_nociception1.99178661
27MP0005167_abnormal_blood-brain_barrier1.86609567
28MP0002735_abnormal_chemical_nociception1.80326453
29MP0005645_abnormal_hypothalamus_physiol1.72693664
30MP0008875_abnormal_xenobiotic_pharmacok1.72523481
31MP0005248_abnormal_Harderian_gland1.71634763
32MP0002938_white_spotting1.67951911
33MP0001501_abnormal_sleep_pattern1.67234477
34MP0002876_abnormal_thyroid_physiology1.67032045
35MP0001986_abnormal_taste_sensitivity1.65059497
36MP0009745_abnormal_behavioral_response1.63432959
37MP0002736_abnormal_nociception_after1.60242451
38MP0002272_abnormal_nervous_system1.53999275
39MP0000569_abnormal_digit_pigmentation1.53832721
40MP0000427_abnormal_hair_cycle1.45515164
41MP0004142_abnormal_muscle_tone1.43316957
42MP0004885_abnormal_endolymph1.43006389
43MP0006292_abnormal_olfactory_placode1.41930227
44MP0004133_heterotaxia1.38786937
45MP0005646_abnormal_pituitary_gland1.35472816
46MP0001970_abnormal_pain_threshold1.26785050
47MP0002733_abnormal_thermal_nociception1.26166433
48MP0002138_abnormal_hepatobiliary_system1.25644173
49MP0010094_abnormal_chromosome_stability1.21949331
50MP0001486_abnormal_startle_reflex1.19777552
51MP0004233_abnormal_muscle_weight1.19139022
52MP0003137_abnormal_impulse_conducting1.18172455
53MP0003705_abnormal_hypodermis_morpholog1.13301950
54MP0001984_abnormal_olfaction1.12222030
55MP0004924_abnormal_behavior1.12073868
56MP0005386_behavior/neurological_phenoty1.12073868
57MP0005410_abnormal_fertilization1.11176123
58MP0006276_abnormal_autonomic_nervous1.09636957
59MP0002064_seizures1.09410260
60MP0002572_abnormal_emotion/affect_behav1.09256308
61MP0002557_abnormal_social/conspecific_i1.09209958
62MP0003453_abnormal_keratinocyte_physiol1.07098073
63MP0002160_abnormal_reproductive_system1.06864989
64MP0001293_anophthalmia1.06085428
65MP0005389_reproductive_system_phenotype1.04465482
66MP0008775_abnormal_heart_ventricle1.04093251
67MP0008057_abnormal_DNA_replication1.03498144
68MP0005084_abnormal_gallbladder_morpholo1.01719955
69MP0000383_abnormal_hair_follicle1.01585940
70MP0000230_abnormal_systemic_arterial1.01350924
71MP0001348_abnormal_lacrimal_gland1.00693710
72MP0003787_abnormal_imprinting1.00629573
73MP0004742_abnormal_vestibular_system1.00452334
74MP0002653_abnormal_ependyma_morphology1.00210558
75MP0005058_abnormal_lysosome_morphology0.99451718
76MP0005197_abnormal_uvea_morphology0.98886343
77MP0010386_abnormal_urinary_bladder0.98424574
78MP0005253_abnormal_eye_physiology0.98002732
79MP0003718_maternal_effect0.97815512
80MP0002638_abnormal_pupillary_reflex0.97395942
81MP0002067_abnormal_sensory_capabilities0.95096569
82MP0000631_abnormal_neuroendocrine_gland0.94981051
83MP0001502_abnormal_circadian_rhythm0.90527097
84MP0004145_abnormal_muscle_electrophysio0.90112885
85MP0002163_abnormal_gland_morphology0.89958527
86MP0010030_abnormal_orbit_morphology0.88664089
87MP0001905_abnormal_dopamine_level0.85341001
88MP0009764_decreased_sensitivity_to0.85244233
89MP0002090_abnormal_vision0.84369178
90MP0002928_abnormal_bile_duct0.83866348
91MP0003252_abnormal_bile_duct0.82379169
92MP0005379_endocrine/exocrine_gland_phen0.81597578
93MP0000538_abnormal_urinary_bladder0.81499496
94MP0002229_neurodegeneration0.81431148
95MP0005085_abnormal_gallbladder_physiolo0.80913969
96MP0001529_abnormal_vocalization0.79613545
97MP0010329_abnormal_lipoprotein_level0.79110336
98MP0003880_abnormal_central_pattern0.77794827
99MP0002734_abnormal_mechanical_nocicepti0.76898925
100MP0002063_abnormal_learning/memory/cond0.75999003
101MP0001919_abnormal_reproductive_system0.75811527
102MP0002751_abnormal_autonomic_nervous0.75752700
103MP0009278_abnormal_bone_marrow0.74739313
104MP0002752_abnormal_somatic_nervous0.73795457
105MP0003011_delayed_dark_adaptation0.72894507
106MP0002254_reproductive_system_inflammat0.71474703
107MP0001963_abnormal_hearing_physiology0.70534701
108MP0003698_abnormal_male_reproductive0.70366321
109MP0005083_abnormal_biliary_tract0.68817315
110MP0000367_abnormal_coat/_hair0.68317895
111MP0000762_abnormal_tongue_morphology0.67214807
112MP0005391_vision/eye_phenotype0.61140895
113MP0002009_preneoplasia0.60064394
114MP0003172_abnormal_lysosome_physiology0.58990603
115MP0000733_abnormal_muscle_development0.57589986
116MP0002089_abnormal_postnatal_growth/wei0.56073161
117MP0005409_darkened_coat_color0.55869070
118MP0010307_abnormal_tumor_latency0.54672807
119MP0003567_abnormal_fetal_cardiomyocyte0.53022901
120MP0002092_abnormal_eye_morphology0.51771090
121MP0003111_abnormal_nucleus_morphology0.48589112
122MP0004197_abnormal_fetal_growth/weight/0.48393219
123MP0010352_gastrointestinal_tract_polyps0.47780420
124MP0005023_abnormal_wound_healing0.46526624
125MP0001485_abnormal_pinna_reflex0.46325037
126MP0003283_abnormal_digestive_organ0.45843213
127MP0003943_abnormal_hepatobiliary_system0.42283185
128MP0003119_abnormal_digestive_system0.41246410
129MP0003566_abnormal_cell_adhesion0.41161237
130MP0005551_abnormal_eye_electrophysiolog0.41094979
131MP0003890_abnormal_embryonic-extraembry0.40523489
132MP0010234_abnormal_vibrissa_follicle0.36559314
133MP0005193_abnormal_anterior_eye0.36227393
134MP0001545_abnormal_hematopoietic_system0.35767117
135MP0005397_hematopoietic_system_phenotyp0.35767117
136MP0002269_muscular_atrophy0.35285622
137MP0006072_abnormal_retinal_apoptosis0.34630816
138MP0002086_abnormal_extraembryonic_tissu0.33890268
139MP0002177_abnormal_outer_ear0.33431658
140MP0001697_abnormal_embryo_size0.33387733
141MP0002084_abnormal_developmental_patter0.31985484
142MP0008770_decreased_survivor_rate0.31054154
143MP0005623_abnormal_meninges_morphology0.29160747
144MP0002282_abnormal_trachea_morphology0.28639547
145MP0001340_abnormal_eyelid_morphology0.25425412
146MP0002697_abnormal_eye_size0.25237181
147MP0000358_abnormal_cell_content/0.24802101
148MP0003786_premature_aging0.24736079
149MP0000377_abnormal_hair_follicle0.24005021
150MP0002249_abnormal_larynx_morphology0.23534604
151MP0009840_abnormal_foam_cell0.23481963
152MP0008932_abnormal_embryonic_tissue0.23411125
153MP0003385_abnormal_body_wall0.23135559
154MP0003950_abnormal_plasma_membrane0.22851488
155MP0001849_ear_inflammation0.22356095
156MP0002085_abnormal_embryonic_tissue0.21849356
157MP0008995_early_reproductive_senescence0.21630780
158MP0003091_abnormal_cell_migration0.19733089
159MP0003077_abnormal_cell_cycle0.19435047
160MP0009046_muscle_twitch0.19130520
161MP0003045_fibrosis0.19127920
162MP0005195_abnormal_posterior_eye0.18444206
163MP0000470_abnormal_stomach_morphology0.18376167
164MP0002111_abnormal_tail_morphology0.17506288
165MP0000350_abnormal_cell_proliferation0.16904791
166MP0000579_abnormal_nail_morphology0.16585478
167MP0002080_prenatal_lethality0.16317222
168MP0004957_abnormal_blastocyst_morpholog0.16101784
169MP0005508_abnormal_skeleton_morphology0.15540268
170MP0005380_embryogenesis_phenotype0.14989911
171MP0001672_abnormal_embryogenesis/_devel0.14989911
172MP0003191_abnormal_cellular_cholesterol0.14655674
173MP0000955_abnormal_spinal_cord0.14536203

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)9.99955936
2Hypoplasia of the fovea (HP:0007750)9.99955936
3Blue irides (HP:0000635)9.58523282
4Ocular albinism (HP:0001107)8.80689389
5Abnormality of the fovea (HP:0000493)8.50005405
6Iris hypopigmentation (HP:0007730)7.68659348
7Hypopigmentation of the fundus (HP:0007894)6.82251949
8Generalized hypopigmentation (HP:0007513)6.76007496
9White forelock (HP:0002211)5.59099448
10Congenital sensorineural hearing impairment (HP:0008527)5.27238851
11Subacute progressive viral hepatitis (HP:0006572)5.11331347
12Patchy hypopigmentation of hair (HP:0011365)4.93510704
13Birth length less than 3rd percentile (HP:0003561)4.77459177
14Bilateral sensorineural hearing impairment (HP:0008619)4.55742140
15Pancreatic cysts (HP:0001737)4.49387532
16Albinism (HP:0001022)4.47328066
17Congenital stationary night blindness (HP:0007642)4.43067459
18Premature graying of hair (HP:0002216)4.35514385
19Cutaneous melanoma (HP:0012056)4.32261321
20Type II lissencephaly (HP:0007260)4.24431436
21Freckling (HP:0001480)4.15012461
22Hypoplasia of the iris (HP:0007676)4.14494936
23Abnormality of midbrain morphology (HP:0002418)4.11185392
24Molar tooth sign on MRI (HP:0002419)4.11185392
25Pancreatic fibrosis (HP:0100732)3.99785849
26True hermaphroditism (HP:0010459)3.76517357
27Hyperventilation (HP:0002883)3.68015376
28Nephronophthisis (HP:0000090)3.64411956
29Heterochromia iridis (HP:0001100)3.60736502
30Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.52033572
31Abnormality of the renal cortex (HP:0011035)3.33209173
32Generalized hypopigmentation of hair (HP:0011358)3.32023106
33Attenuation of retinal blood vessels (HP:0007843)3.30080888
34Mucopolysacchariduria (HP:0008155)3.22799059
35Urinary glycosaminoglycan excretion (HP:0003541)3.22799059
36Abnormality of the renal medulla (HP:0100957)3.19058654
37Pendular nystagmus (HP:0012043)3.10092361
38Inability to walk (HP:0002540)3.08941910
39Asymmetric septal hypertrophy (HP:0001670)2.96153502
40Abolished electroretinogram (ERG) (HP:0000550)2.95577920
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91111911
42Abnormality of polysaccharide metabolism (HP:0011012)2.91111911
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91111911
44Cerebellar dysplasia (HP:0007033)2.90941906
45Large for gestational age (HP:0001520)2.90317232
46Tubular atrophy (HP:0000092)2.84887631
47Medial flaring of the eyebrow (HP:0010747)2.78517052
48Viral hepatitis (HP:0006562)2.77875677
49Breast hypoplasia (HP:0003187)2.75916041
50Patellar aplasia (HP:0006443)2.75817528
51Dysostosis multiplex (HP:0000943)2.75453063
52Lissencephaly (HP:0001339)2.73657346
53Cystic liver disease (HP:0006706)2.70555408
54Pustule (HP:0200039)2.68437086
55Abnormal rod and cone electroretinograms (HP:0008323)2.67404949
56Micronodular cirrhosis (HP:0001413)2.65946966
57Aplasia/Hypoplasia of the patella (HP:0006498)2.65124910
58Progressive inability to walk (HP:0002505)2.63139376
59Keratoconus (HP:0000563)2.58552707
60Increased corneal curvature (HP:0100692)2.58552707
61Polydipsia (HP:0001959)2.58143658
62Abnormal drinking behavior (HP:0030082)2.58143658
63Chorioretinal atrophy (HP:0000533)2.57711348
64Decreased central vision (HP:0007663)2.55750586
65Microretrognathia (HP:0000308)2.54699100
66Abnormality of the pons (HP:0007361)2.52407118
67Hypochromic microcytic anemia (HP:0004840)2.51348003
68Hypoplasia of the pons (HP:0012110)2.45617913
69Chronic hepatic failure (HP:0100626)2.45040174
70Annular pancreas (HP:0001734)2.41097538
71Protruding tongue (HP:0010808)2.36855972
72Hyperalaninemia (HP:0003348)2.36715281
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36715281
74Abnormality of alanine metabolism (HP:0010916)2.36715281
75Ulnar bowing (HP:0003031)2.33471845
76Hepatocellular carcinoma (HP:0001402)2.32056635
77Turricephaly (HP:0000262)2.28942372
78Clumsiness (HP:0002312)2.28705728
79Genetic anticipation (HP:0003743)2.26849345
80Abnormality of vision evoked potentials (HP:0000649)2.26111212
81Alacrima (HP:0000522)2.24650832
82Rectal fistula (HP:0100590)2.22398827
83Rectovaginal fistula (HP:0000143)2.22398827
84Gait imbalance (HP:0002141)2.18078178
85Polyuria (HP:0000103)2.17483914
86Bony spicule pigmentary retinopathy (HP:0007737)2.17430170
87Rib fusion (HP:0000902)2.16932302
88Absent/shortened dynein arms (HP:0200106)2.16009334
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.16009334
90Congenital, generalized hypertrichosis (HP:0004540)2.16001623
91Congenital primary aphakia (HP:0007707)2.15695542
92Alopecia of scalp (HP:0002293)2.15578296
93Gaze-evoked nystagmus (HP:0000640)2.15045085
94Facial hemangioma (HP:0000329)2.14309845
95Sclerocornea (HP:0000647)2.14107740
96Renal cortical cysts (HP:0000803)2.13152455
97Narrow nasal bridge (HP:0000446)2.13122270
98Decreased circulating renin level (HP:0003351)2.12994422
99Abnormal hemoglobin (HP:0011902)2.12985798
100Tongue fasciculations (HP:0001308)2.12272477
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11436463
102Concave nail (HP:0001598)2.11196699
103Abnormal respiratory epithelium morphology (HP:0012253)2.07779419
104Abnormal respiratory motile cilium morphology (HP:0005938)2.07779419
105Severe muscular hypotonia (HP:0006829)2.07320721
106Mitochondrial inheritance (HP:0001427)2.04991968
107Broad-based gait (HP:0002136)2.04990774
108Furrowed tongue (HP:0000221)2.04413384
109Congenital hepatic fibrosis (HP:0002612)2.04357512
110Increased CSF lactate (HP:0002490)2.03988248
111Retinal dysplasia (HP:0007973)2.03789364
112Poikiloderma (HP:0001029)2.03677716
113Aplasia/Hypoplasia of the tongue (HP:0010295)2.02810545
114Nephrogenic diabetes insipidus (HP:0009806)2.01530133
115Anencephaly (HP:0002323)2.01485390
116Rhabdomyosarcoma (HP:0002859)2.01299489
117Aplasia/Hypoplasia of the macula (HP:0008059)10.8844510
118Aplasia/Hypoplasia affecting the retina (HP:0008061)10.1901532
119Orthostatic hypotension (HP:0001278)1.99129734
120Tented upper lip vermilion (HP:0010804)1.98155917
121Progressive cerebellar ataxia (HP:0002073)1.96940197
122Vaginal fistula (HP:0004320)1.96719441
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.96050086
124Joint stiffness (HP:0001387)1.95440647
125Short chin (HP:0000331)1.93989619
126Hypothermia (HP:0002045)1.93811586
127Muscle fibrillation (HP:0010546)1.93668449
128Melanoma (HP:0002861)1.93111388
129Short humerus (HP:0005792)1.92705155
130Intestinal fistula (HP:0100819)1.92184603
131Absent speech (HP:0001344)1.89308793
132Abnormal biliary tract physiology (HP:0012439)1.87510115
133Bile duct proliferation (HP:0001408)1.87510115
134Abnormal ciliary motility (HP:0012262)1.86164217
135Stomach cancer (HP:0012126)1.84570688
136Fair hair (HP:0002286)1.82925757
137Optic nerve hypoplasia (HP:0000609)1.82579581
138Underdeveloped nasal alae (HP:0000430)1.81880980
139Optic disc pallor (HP:0000543)1.81650841
140Renal cell carcinoma (HP:0005584)1.79770383
141Aplasia/hypoplasia of the humerus (HP:0006507)1.77612758
142Spastic diplegia (HP:0001264)1.76994716
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.76973543
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76858205
145Pachygyria (HP:0001302)1.76220432
146Hepatocellular necrosis (HP:0001404)1.75762720
147Spinal muscular atrophy (HP:0007269)1.74838452
148Male pseudohermaphroditism (HP:0000037)1.74713465
149Widely spaced teeth (HP:0000687)1.73775302
150Acute necrotizing encephalopathy (HP:0006965)1.73313522
151Lipid accumulation in hepatocytes (HP:0006561)1.71835613
152Abnormal urine output (HP:0012590)1.71335408
153Bulbous nose (HP:0000414)1.69257120
154Postaxial foot polydactyly (HP:0001830)1.68824401
155Decreased lacrimation (HP:0000633)1.68822887
156Methylmalonic aciduria (HP:0012120)1.68493843
157Increased IgM level (HP:0003496)1.66193095
158Synophrys (HP:0000664)1.65212889
159Premature skin wrinkling (HP:0100678)1.64766773
160Coronal craniosynostosis (HP:0004440)1.62636287
161Coarse hair (HP:0002208)1.60325667
162Male infertility (HP:0003251)1.59862801
163Abnormal auditory evoked potentials (HP:0006958)1.55912994
164Hamartoma (HP:0010566)1.51099498
165Cerebral aneurysm (HP:0004944)1.51070113
166Polycythemia (HP:0001901)1.50115452
167Hypokinesia (HP:0002375)1.49528460
168Carpal synostosis (HP:0009702)1.47184022
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.44050678
170Melanocytic nevus (HP:0000995)1.42656965
171Neoplasm of striated muscle (HP:0009728)1.41694323
172Hypotelorism (HP:0000601)1.34283330
173Vertebral hypoplasia (HP:0008417)1.33574579
174Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.33574579
175Scapular winging (HP:0003691)1.32815974
176Supernumerary ribs (HP:0005815)1.32134915
177Congenital hip dislocation (HP:0001374)1.32114927
178Hypermelanotic macule (HP:0001034)1.31792007
179Neoplasm of the liver (HP:0002896)1.29924421
180Abnormal gallbladder physiology (HP:0012438)1.28899020
181Cholecystitis (HP:0001082)1.28899020
182Hamartoma of the eye (HP:0010568)1.25993032
183Squamous cell carcinoma (HP:0002860)1.24514193
184Abnormality of the aortic arch (HP:0012303)1.22933836
185Shawl scrotum (HP:0000049)1.22678326
186Anteriorly placed anus (HP:0001545)1.21330097
187Decreased electroretinogram (ERG) amplitude (HP:0000654)1.21079451
188Photophobia (HP:0000613)1.20615602
189Basal cell carcinoma (HP:0002671)1.18710447
190Dysautonomia (HP:0002459)1.15749531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.53250395
2MET4.63227795
3BMPR1B4.48705268
4BMX4.47706645
5ACVR1B4.18072281
6DDR23.79022631
7ADRBK23.61585717
8ZAK3.46707116
9MARK33.21687777
10ICK3.19377032
11DAPK22.70555893
12WEE12.67089663
13PKN22.60769355
14WNK42.57398270
15CASK2.49020806
16MAPK152.45867707
17MAP3K62.43566985
18GRK12.33225400
19TRIB32.30032205
20MAP4K22.27926532
21MAP3K112.02660725
22MST1R10.6631284
23TGFBR11.97673904
24TAOK31.96009961
25WNK31.92516625
26FGR1.82152633
27INSRR1.81193203
28NUAK11.79380088
29TYRO31.74359149
30TXK1.57495378
31MAP3K41.57318644
32ADRBK11.53640758
33MAPK131.45870452
34EPHA31.43873988
35PDGFRA1.43793422
36MATK1.42246201
37CAMKK21.35177364
38PINK11.34662729
39GSK3A1.29218391
40MKNK21.29158525
41OXSR11.22910107
42SCYL21.20135609
43PTK2B1.16908259
44DYRK1B1.15703570
45MAP2K61.14252329
46STK38L1.12171755
47CDK71.11873184
48STK391.11328578
49DAPK11.10683612
50BCKDK1.08584186
51UHMK11.08069282
52MAP2K71.07115834
53CSK1.06723852
54MAPKAPK31.05327408
55VRK11.00574320
56LATS10.99307668
57CDK60.95491089
58TRPM70.93366384
59LATS20.92205901
60NME10.90917198
61TIE10.88321392
62PRKCG0.83607071
63SIK20.82345735
64YES10.82121995
65PRKD20.81167601
66PAK30.81150166
67PRKCE0.78691738
68PIM20.77975237
69CSNK1G10.76386738
70RPS6KA50.73383805
71NEK10.71917613
72KIT0.71139951
73FLT30.71005315
74MUSK0.70109303
75IKBKB0.69456895
76PIK3CA0.66979868
77DYRK20.65830289
78CHEK20.64808509
79PHKG10.59909048
80PHKG20.59909048
81PRKCQ0.59879937
82PRKCI0.59327512
83PIM10.58861492
84TNIK0.58612964
85MAPK110.55822481
86CAMK2A0.55531254
87MAP3K90.54103534
88BRSK20.53618632
89CAMK10.52365081
90RPS6KB20.51748341
91PKN10.50576033
92MAPKAPK50.48874183
93CAMK1D0.48576907
94MAP2K10.48218215
95RPS6KA10.46324317
96CHUK0.46058833
97RAF10.45200138
98NTRK20.44672810
99CDC42BPA0.44070717
100GRK70.43446948
101NTRK30.43400471
102TEC0.43007993
103MKNK10.42905621
104RPS6KL10.42694568
105RPS6KC10.42694568
106CSNK1A10.42470097
107MAP3K70.41019235
108TRIM280.40939849
109CSNK1G30.40718144
110AKT30.40063369
111TTN0.39936771
112PLK20.39337008
113PRKACA0.38058227
114MAP2K40.37380832
115MTOR0.37375899
116PTK60.37155903
117TAF10.37094960
118PRKCH0.36935991
119PRKAA10.36934617
120MAP3K100.35586856
121CAMK40.34720758
122INSR0.34636395
123RIPK10.34462246
124CSNK1A1L0.34298989
125MARK10.33562740
126PAK40.33369805
127HIPK20.32722186
128PRKCZ0.31892709
129MELK0.31244336
130VRK20.30838421
131LRRK20.30772163
132STK110.30543349
133RPS6KA60.30287601
134STK30.29297906
135PDGFRB0.29256858
136WNK10.28736494
137PRKCA0.28085819
138PNCK0.27881647
139AKT20.27829813
140ITK0.27739193
141MAP4K10.27133557
142CSNK1D0.27111313
143SYK0.26235657
144PAK60.25828358
145PRKAA20.25809345
146MAPK30.25587782
147PIK3CG0.25566283
148MAP2K20.25439329
149PLK10.24339178
150ILK0.23234925
151CSNK1G20.22235360
152ALK0.22215509
153DMPK0.22116099
154LYN0.20978588
155CAMKK10.20039464
156NEK20.19079570
157EGFR0.18264983
158ERBB30.17910790
159CAMK2B0.17621590
160TLK10.16174732
161PAK20.15959403
162AURKA0.15651284
163ABL10.14905548
164PTK20.14513086
165ATR0.14088667
166PRKG20.14053122
167RPS6KB10.13986374
168FGFR10.13315171
169CDK20.13278579
170KSR20.12643688
171FER0.12279585
172CDK40.11921276
173MAPKAPK20.11365061
174MAPK10.10852206
175MAP3K80.10297077
176RET0.09460729
177PRKD10.09424474
178DYRK30.09340856
179SGK10.09155594
180MAPK140.08034456

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003507.35597022
2Fatty acid biosynthesis_Homo sapiens_hsa000614.27952967
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.71987099
4Phototransduction_Homo sapiens_hsa047442.93889876
5Melanogenesis_Homo sapiens_hsa049162.87055397
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62337181
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55970810
8Mismatch repair_Homo sapiens_hsa034302.55754240
9Nitrogen metabolism_Homo sapiens_hsa009102.53116431
10Base excision repair_Homo sapiens_hsa034102.50440862
11Butanoate metabolism_Homo sapiens_hsa006502.40978376
12Selenocompound metabolism_Homo sapiens_hsa004502.35610802
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25371926
14Adherens junction_Homo sapiens_hsa045202.23086855
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22596398
16Galactose metabolism_Homo sapiens_hsa000522.15666859
17Biosynthesis of amino acids_Homo sapiens_hsa012302.15484650
18Central carbon metabolism in cancer_Homo sapiens_hsa052302.14280968
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11294834
20Tryptophan metabolism_Homo sapiens_hsa003802.08282390
21mTOR signaling pathway_Homo sapiens_hsa041502.01844393
22Maturity onset diabetes of the young_Homo sapiens_hsa049502.01682430
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.94418902
24Oxidative phosphorylation_Homo sapiens_hsa001901.87670534
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87252585
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86503607
27ABC transporters_Homo sapiens_hsa020101.85962228
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85611772
29Fructose and mannose metabolism_Homo sapiens_hsa000511.83482459
30Nicotine addiction_Homo sapiens_hsa050331.81470722
31DNA replication_Homo sapiens_hsa030301.71856068
32Ether lipid metabolism_Homo sapiens_hsa005651.71044901
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58779001
34RNA polymerase_Homo sapiens_hsa030201.50868816
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45315256
36Melanoma_Homo sapiens_hsa052181.44718488
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.44696391
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44274973
39Caffeine metabolism_Homo sapiens_hsa002321.43327699
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40118899
41Basal transcription factors_Homo sapiens_hsa030221.38944521
42Circadian rhythm_Homo sapiens_hsa047101.33376290
43Parkinsons disease_Homo sapiens_hsa050121.28029387
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27238956
45Arginine and proline metabolism_Homo sapiens_hsa003301.25663328
46Olfactory transduction_Homo sapiens_hsa047401.24993356
47Fatty acid metabolism_Homo sapiens_hsa012121.22732523
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.21682389
49Chemical carcinogenesis_Homo sapiens_hsa052041.21096812
50Hippo signaling pathway_Homo sapiens_hsa043901.18921111
51Morphine addiction_Homo sapiens_hsa050321.17974941
52Renal cell carcinoma_Homo sapiens_hsa052111.16323627
53Arachidonic acid metabolism_Homo sapiens_hsa005901.16097924
54Protein export_Homo sapiens_hsa030601.14141738
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13887472
56Propanoate metabolism_Homo sapiens_hsa006401.13682475
57Taste transduction_Homo sapiens_hsa047421.11967645
58Starch and sucrose metabolism_Homo sapiens_hsa005001.11215247
59p53 signaling pathway_Homo sapiens_hsa041151.10562996
60Peroxisome_Homo sapiens_hsa041461.09196963
61Nucleotide excision repair_Homo sapiens_hsa034201.08365100
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08286357
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.06481590
64MicroRNAs in cancer_Homo sapiens_hsa052061.04905698
65One carbon pool by folate_Homo sapiens_hsa006701.04087259
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02560348
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01597968
68Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01011119
69Insulin secretion_Homo sapiens_hsa049110.99157586
70VEGF signaling pathway_Homo sapiens_hsa043700.98352902
71Serotonergic synapse_Homo sapiens_hsa047260.97747032
72Asthma_Homo sapiens_hsa053100.97387261
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93418727
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93139290
75Notch signaling pathway_Homo sapiens_hsa043300.92345143
76RNA degradation_Homo sapiens_hsa030180.92279829
77GABAergic synapse_Homo sapiens_hsa047270.92136820
78Ovarian steroidogenesis_Homo sapiens_hsa049130.91320619
79Retinol metabolism_Homo sapiens_hsa008300.91250056
80Huntingtons disease_Homo sapiens_hsa050160.90117862
81beta-Alanine metabolism_Homo sapiens_hsa004100.89049276
82Arginine biosynthesis_Homo sapiens_hsa002200.87862758
83Lysosome_Homo sapiens_hsa041420.86990725
84Hedgehog signaling pathway_Homo sapiens_hsa043400.86359022
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86241910
86Histidine metabolism_Homo sapiens_hsa003400.85889332
87Circadian entrainment_Homo sapiens_hsa047130.85645260
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85435695
89Glycerolipid metabolism_Homo sapiens_hsa005610.85239726
90Chronic myeloid leukemia_Homo sapiens_hsa052200.85202605
91HIF-1 signaling pathway_Homo sapiens_hsa040660.84439369
92Small cell lung cancer_Homo sapiens_hsa052220.82109757
93Alzheimers disease_Homo sapiens_hsa050100.81387583
94Lysine degradation_Homo sapiens_hsa003100.80037728
95Calcium signaling pathway_Homo sapiens_hsa040200.78935250
96RNA transport_Homo sapiens_hsa030130.78779828
97Salivary secretion_Homo sapiens_hsa049700.78120363
98Fanconi anemia pathway_Homo sapiens_hsa034600.77866297
99Proteoglycans in cancer_Homo sapiens_hsa052050.77657309
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77495156
101N-Glycan biosynthesis_Homo sapiens_hsa005100.76562566
102mRNA surveillance pathway_Homo sapiens_hsa030150.76255935
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75462548
104Tight junction_Homo sapiens_hsa045300.73700285
105Oocyte meiosis_Homo sapiens_hsa041140.73150754
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71934613
107Cardiac muscle contraction_Homo sapiens_hsa042600.71408725
108Regulation of autophagy_Homo sapiens_hsa041400.71037008
109Glutamatergic synapse_Homo sapiens_hsa047240.70840881
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70272356
111Collecting duct acid secretion_Homo sapiens_hsa049660.69468481
112ErbB signaling pathway_Homo sapiens_hsa040120.69418719
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68450968
114Shigellosis_Homo sapiens_hsa051310.68417097
115Colorectal cancer_Homo sapiens_hsa052100.68381967
116Viral carcinogenesis_Homo sapiens_hsa052030.68132725
117Insulin signaling pathway_Homo sapiens_hsa049100.67177756
118Carbon metabolism_Homo sapiens_hsa012000.66161555
119Focal adhesion_Homo sapiens_hsa045100.66134782
120Metabolic pathways_Homo sapiens_hsa011000.65717673
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65523169
122Bladder cancer_Homo sapiens_hsa052190.64634575
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63946658
124Systemic lupus erythematosus_Homo sapiens_hsa053220.63698582
125Primary immunodeficiency_Homo sapiens_hsa053400.63513006
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63210937
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62966177
128Sulfur metabolism_Homo sapiens_hsa009200.62641128
129Purine metabolism_Homo sapiens_hsa002300.61217815
130Pentose phosphate pathway_Homo sapiens_hsa000300.60892536
131AMPK signaling pathway_Homo sapiens_hsa041520.59554535
132Type I diabetes mellitus_Homo sapiens_hsa049400.59074399
133Cell cycle_Homo sapiens_hsa041100.59028426
134Graft-versus-host disease_Homo sapiens_hsa053320.57615551
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.56312626
136TGF-beta signaling pathway_Homo sapiens_hsa043500.55509441
137Spliceosome_Homo sapiens_hsa030400.54831307
138Steroid biosynthesis_Homo sapiens_hsa001000.54520064
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52326662
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50227037
141Allograft rejection_Homo sapiens_hsa053300.49710149
142Sulfur relay system_Homo sapiens_hsa041220.49611192
143Wnt signaling pathway_Homo sapiens_hsa043100.48641479
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48098996
145Vitamin digestion and absorption_Homo sapiens_hsa049770.47991858
146Endometrial cancer_Homo sapiens_hsa052130.47834523
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47656694
148Pyrimidine metabolism_Homo sapiens_hsa002400.47642328
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.47463260
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.47086421
151Prostate cancer_Homo sapiens_hsa052150.45681579
152Autoimmune thyroid disease_Homo sapiens_hsa053200.45348609
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43009090
154Dorso-ventral axis formation_Homo sapiens_hsa043200.42606965
155Fat digestion and absorption_Homo sapiens_hsa049750.40979066
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.39935042
157Basal cell carcinoma_Homo sapiens_hsa052170.39494915
158Estrogen signaling pathway_Homo sapiens_hsa049150.39328280
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38748316
160Glioma_Homo sapiens_hsa052140.37846255
161Fatty acid degradation_Homo sapiens_hsa000710.36262643
162Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33238871
163Linoleic acid metabolism_Homo sapiens_hsa005910.32350834
164Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31779576
165Sphingolipid metabolism_Homo sapiens_hsa006000.31542241
166Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30860376
167Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29737323
168PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29409503
169Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29216574
170Mineral absorption_Homo sapiens_hsa049780.28867849
171Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28655762
172Homologous recombination_Homo sapiens_hsa034400.26890110
173Glucagon signaling pathway_Homo sapiens_hsa049220.26789493
174Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26377764
175Rap1 signaling pathway_Homo sapiens_hsa040150.25947259
176Axon guidance_Homo sapiens_hsa043600.25463516
177Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24362359
178Malaria_Homo sapiens_hsa051440.24326787
179Acute myeloid leukemia_Homo sapiens_hsa052210.23941451
180Viral myocarditis_Homo sapiens_hsa054160.23353350
181Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22559648

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