TSPAN15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.87442162
2central nervous system myelination (GO:0022010)9.87442162
3fatty acid elongation (GO:0030497)7.03555104
4ensheathment of neurons (GO:0007272)6.89162972
5axon ensheathment (GO:0008366)6.89162972
6myelination (GO:0042552)6.85480420
7long-chain fatty acid biosynthetic process (GO:0042759)5.24278014
8negative regulation of neurotransmitter secretion (GO:0046929)5.17474291
9oligodendrocyte differentiation (GO:0048709)4.86126644
10cholesterol biosynthetic process (GO:0006695)4.68603157
11eye photoreceptor cell differentiation (GO:0001754)4.57392713
12photoreceptor cell differentiation (GO:0046530)4.57392713
13virion attachment to host cell (GO:0019062)4.57304119
14adhesion of symbiont to host cell (GO:0044650)4.57304119
15Golgi transport vesicle coating (GO:0048200)4.44525416
16COPI coating of Golgi vesicle (GO:0048205)4.44525416
17myelin maintenance (GO:0043217)4.41789487
18barbed-end actin filament capping (GO:0051016)4.34006411
19glycerophospholipid catabolic process (GO:0046475)4.33985937
20negative regulation of neurotransmitter transport (GO:0051589)4.30781610
21asymmetric protein localization (GO:0008105)4.26860570
22presynaptic membrane assembly (GO:0097105)4.24388885
23peptidyl-tyrosine autophosphorylation (GO:0038083)4.13192958
24presynaptic membrane organization (GO:0097090)4.09210627
25apical protein localization (GO:0045176)4.09195536
26desmosome organization (GO:0002934)4.06975666
27sterol biosynthetic process (GO:0016126)4.05408647
28astrocyte development (GO:0014002)4.00628719
29protein retention in ER lumen (GO:0006621)4.00028746
30response to redox state (GO:0051775)4.00009877
31creatine metabolic process (GO:0006600)3.99681815
32primary alcohol catabolic process (GO:0034310)3.92299932
33negative regulation of protein localization to cell surface (GO:2000009)3.87041790
34peripheral nervous system axon ensheathment (GO:0032292)3.86214063
35myelination in peripheral nervous system (GO:0022011)3.86214063
36epithelial cell-cell adhesion (GO:0090136)3.83646197
37substantia nigra development (GO:0021762)3.83097841
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.81489140
39regulation of collateral sprouting (GO:0048670)3.78918599
40positive regulation of Cdc42 GTPase activity (GO:0043089)3.73824016
41positive regulation of action potential (GO:0045760)3.73615611
42response to lipoprotein particle (GO:0055094)3.69656442
43long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.63922363
44amyloid precursor protein metabolic process (GO:0042982)3.59707993
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.59599797
46nucleotide transmembrane transport (GO:1901679)3.59407801
47endothelial cell chemotaxis (GO:0035767)3.57599175
48NADH metabolic process (GO:0006734)3.54095921
49cytoskeletal anchoring at plasma membrane (GO:0007016)3.53208631
50positive regulation of oligodendrocyte differentiation (GO:0048714)3.53120624
51renal filtration (GO:0097205)3.52705074
52adhesion of symbiont to host (GO:0044406)3.51819332
53establishment of mitochondrion localization (GO:0051654)3.50987058
54isoprenoid biosynthetic process (GO:0008299)3.50671103
55response to hepatocyte growth factor (GO:0035728)3.45658114
56cellular response to hepatocyte growth factor stimulus (GO:0035729)3.45658114
57import into cell (GO:0098657)3.34934836
58long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.34502549
59glomerular filtration (GO:0003094)3.34359971
60retina vasculature morphogenesis in camera-type eye (GO:0061299)3.33381601
61glycosylceramide metabolic process (GO:0006677)3.32756974
62semaphorin-plexin signaling pathway (GO:0071526)3.32652343
63endothelium development (GO:0003158)3.30687234
64magnesium ion transport (GO:0015693)3.26127756
65interleukin-6-mediated signaling pathway (GO:0070102)3.24186674
66limb bud formation (GO:0060174)3.23956741
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22467328
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.21154197
69GPI anchor biosynthetic process (GO:0006506)3.19043652
70L-amino acid import (GO:0043092)3.18976797
71protein palmitoylation (GO:0018345)3.16070398
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.15855467
73transmission of nerve impulse (GO:0019226)3.15808343
74transcytosis (GO:0045056)3.14084797
75fatty-acyl-CoA biosynthetic process (GO:0046949)3.12352708
76GPI anchor metabolic process (GO:0006505)3.12009158
77cerebral cortex radially oriented cell migration (GO:0021799)3.11892720
78vitamin transmembrane transport (GO:0035461)3.10214124
79leukocyte migration involved in inflammatory response (GO:0002523)3.10203520
80calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.10045759
81branching involved in mammary gland duct morphogenesis (GO:0060444)3.09553555
82positive regulation of pseudopodium assembly (GO:0031274)3.08615476
83low-density lipoprotein particle clearance (GO:0034383)3.04168790
84regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.03610949
85protein localization to endosome (GO:0036010)3.02535267
86bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00182305
87ethanol metabolic process (GO:0006067)2.99807856
88response to methylmercury (GO:0051597)2.97547614
89cellular response to epinephrine stimulus (GO:0071872)2.96835040
90negative regulation of JUN kinase activity (GO:0043508)2.96818572
91negative regulation of axonogenesis (GO:0050771)2.96490554
92peripheral nervous system development (GO:0007422)2.93248299
93apoptotic cell clearance (GO:0043277)2.93224969
94preassembly of GPI anchor in ER membrane (GO:0016254)2.92580864
95membrane assembly (GO:0071709)2.90100710
96ear development (GO:0043583)2.86255762
97vascular endothelial growth factor signaling pathway (GO:0038084)2.85324695
98amyloid precursor protein catabolic process (GO:0042987)2.85012012
99renal system process involved in regulation of blood volume (GO:0001977)2.84763768
100fatty-acyl-CoA metabolic process (GO:0035337)2.84494875
101endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.84211099
102glutathione biosynthetic process (GO:0006750)2.83053083
103L-serine transport (GO:0015825)2.82177372
104surfactant homeostasis (GO:0043129)2.81313191
105regulation of pseudopodium assembly (GO:0031272)2.78691137
106protein maturation by protein folding (GO:0022417)2.77382173
107cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.76393125
108glucose catabolic process (GO:0006007)2.74990496
109positive regulation of cellular amine metabolic process (GO:0033240)2.74280131
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74064242
111axon development (GO:0061564)2.71497380
112Leydig cell differentiation (GO:0033327)2.71411933
113regulation of glomerular filtration (GO:0003093)2.71035930
114multicellular organismal water homeostasis (GO:0050891)2.70656198
115cranial nerve development (GO:0021545)2.69477470
116membrane tubulation (GO:0097320)2.69416572
117GDP-mannose metabolic process (GO:0019673)2.68371032
118pentose-phosphate shunt (GO:0006098)2.68032298
119epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67980234
120Golgi to plasma membrane protein transport (GO:0043001)2.67779968
121response to epinephrine (GO:0071871)2.66952376
122intestinal epithelial cell development (GO:0060576)2.63563292
123neural nucleus development (GO:0048857)2.63381152
124negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.63292645
125glial cell development (GO:0021782)2.62863619
126glycosphingolipid catabolic process (GO:0046479)2.62770977
127nonribosomal peptide biosynthetic process (GO:0019184)2.61921630
128branching involved in salivary gland morphogenesis (GO:0060445)2.60893821
129glial cell differentiation (GO:0010001)2.60462786
130glycolipid catabolic process (GO:0019377)2.60299941
131nerve growth factor signaling pathway (GO:0038180)2.59187149
132positive regulation of glial cell differentiation (GO:0045687)2.58957461
133very long-chain fatty acid metabolic process (GO:0000038)2.58874959
134prostaglandin biosynthetic process (GO:0001516)2.58472965
135prostanoid biosynthetic process (GO:0046457)2.58472965
136adherens junction assembly (GO:0034333)2.58406649
137regulation of receptor binding (GO:1900120)2.58325866
138basement membrane organization (GO:0071711)2.58291466
139nucleotide transport (GO:0006862)2.56931715
140ethanol oxidation (GO:0006069)2.56651067
141positive regulation of receptor recycling (GO:0001921)2.56009972
142amino acid import (GO:0043090)2.55705952
143axonemal dynein complex assembly (GO:0070286)2.55252406
144negative regulation of execution phase of apoptosis (GO:1900118)2.54149813
145glucose 6-phosphate metabolic process (GO:0051156)2.53236399
146positive regulation of actin filament depolymerization (GO:0030836)2.53132311
147peptidyl-cysteine modification (GO:0018198)2.52426015
148negative regulation of axon extension (GO:0030517)2.52197554
149organ growth (GO:0035265)2.51634096
150activation of Rac GTPase activity (GO:0032863)2.51194806
151fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50681396
152sperm capacitation (GO:0048240)2.50674987
153neuronal ion channel clustering (GO:0045161)2.49646098
154adult walking behavior (GO:0007628)2.49020991
155cyclooxygenase pathway (GO:0019371)2.48964298
156cell volume homeostasis (GO:0006884)2.48370220
157peptidyl-proline hydroxylation (GO:0019511)2.47543365
158regulation of water loss via skin (GO:0033561)2.47058740
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46810313
160negative regulation of myoblast differentiation (GO:0045662)2.46046773
161regulation of cholesterol biosynthetic process (GO:0045540)2.45882690
162diterpenoid biosynthetic process (GO:0016102)2.45361562
163enteric nervous system development (GO:0048484)2.44989876
164thioester biosynthetic process (GO:0035384)2.44824704
165acyl-CoA biosynthetic process (GO:0071616)2.44824704
166proline biosynthetic process (GO:0006561)2.44346883
167prostaglandin metabolic process (GO:0006693)2.43733862
168prostanoid metabolic process (GO:0006692)2.43733862
169neuronal action potential propagation (GO:0019227)2.43215150
170regulation of somitogenesis (GO:0014807)2.43033189
171phosphatidylserine metabolic process (GO:0006658)2.42899743
172peptide catabolic process (GO:0043171)2.42317980
1734-hydroxyproline metabolic process (GO:0019471)2.42078800
174neurotransmitter catabolic process (GO:0042135)2.42037370
175positive regulation of protein localization to plasma membrane (GO:1903078)2.41565545
176neuron remodeling (GO:0016322)2.41542688
177morphogenesis of an endothelium (GO:0003159)2.41208495
178endothelial tube morphogenesis (GO:0061154)2.41208495
179neuron cell-cell adhesion (GO:0007158)2.40281711
180daunorubicin metabolic process (GO:0044597)2.38525210
181polyketide metabolic process (GO:0030638)2.38525210
182doxorubicin metabolic process (GO:0044598)2.38525210
183NADPH regeneration (GO:0006740)2.37684928
184response to water (GO:0009415)2.37203159
185tight junction assembly (GO:0070830)2.37011348
186membrane protein ectodomain proteolysis (GO:0006509)2.36526332
187cell-cell junction assembly (GO:0007043)2.35190409
188positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.34217442
189sexual reproduction (GO:0019953)2.33056278
190positive regulation of endothelial cell apoptotic process (GO:2000353)2.31291977
191regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.31191436
192negative regulation of cell fate specification (GO:0009996)2.30976286
193cellular copper ion homeostasis (GO:0006878)2.30702119
194regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30584015
195angiogenesis involved in wound healing (GO:0060055)2.30567829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.82370220
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52273389
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.23313660
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.22722493
5GBX2_23144817_ChIP-Seq_PC3_Human3.18548822
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11336289
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.10615305
8ZNF263_19887448_ChIP-Seq_K562_Human2.88452241
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.69608069
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53874330
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.51969550
12LXR_22292898_ChIP-Seq_THP-1_Human2.43228967
13* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.33984824
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.33537401
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.29076550
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25738187
17CLOCK_20551151_ChIP-Seq_293T_Human2.24629902
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.21088973
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.15754289
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15636281
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.14026944
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.14023860
23TAF15_26573619_Chip-Seq_HEK293_Human2.12108321
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00349686
25VDR_22108803_ChIP-Seq_LS180_Human1.99606087
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.97715294
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97579658
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94814434
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94769625
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.92297558
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90396769
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90136439
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.87295912
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84683270
35* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83545665
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82130911
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82130911
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.81473731
39* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.81075813
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80415856
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79472875
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75367976
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75170742
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74957443
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74729751
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72416236
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71902602
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68600881
49ER_23166858_ChIP-Seq_MCF-7_Human1.67097408
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65480111
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63767786
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61170294
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.61015090
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60491915
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.58555501
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56915227
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.55098783
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.54799891
59EZH2_22144423_ChIP-Seq_EOC_Human1.54384665
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53819974
61* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52051564
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50748548
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.50144025
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.48420463
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48243659
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.48218098
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47094087
68* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47051632
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46912937
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46606066
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46513378
72DROSHA_22980978_ChIP-Seq_HELA_Human1.46450537
73* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45555115
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45191456
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43753800
76* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43479715
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42989596
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42399460
79PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42312919
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41392240
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41202233
82SMC4_20622854_ChIP-Seq_HELA_Human1.41074740
83KDM2B_26808549_Chip-Seq_K562_Human1.40341504
84AR_21572438_ChIP-Seq_LNCaP_Human1.39769827
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39553969
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39312605
87* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38761092
88GATA6_25053715_ChIP-Seq_YYC3_Human1.36329628
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35249834
90* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35243834
91ATF3_27146783_Chip-Seq_COLON_Human1.35126094
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34100344
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31775587
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31721089
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.31420203
96* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31312250
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31206128
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31088030
99P68_20966046_ChIP-Seq_HELA_Human1.30675368
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.29640754
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.27630296
102P300_19829295_ChIP-Seq_ESCs_Human1.25446216
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24563513
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24563513
105* KLF5_25053715_ChIP-Seq_YYC3_Human1.22778376
106CTCF_27219007_Chip-Seq_Bcells_Human1.21907742
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21644630
108FUS_26573619_Chip-Seq_HEK293_Human1.21502386
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20802348
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19802160
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19060282
112* GATA3_24758297_ChIP-Seq_MCF-7_Human1.18989802
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18816028
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18041902
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16145322
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16076836
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15817036
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15248819
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14939194
120SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14404948
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.14159487
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.14159487
123ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13867288
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13167614
125CREB1_26743006_Chip-Seq_LNCaP_Human1.11346963
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10785171
127* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10481531
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10254146
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10243520
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.10226888
131TP63_22573176_ChIP-Seq_HFKS_Human1.10174416
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09370171
133* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08687231
134* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08687231
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08444245
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.07755246
137* STAT3_23295773_ChIP-Seq_U87_Human1.07657638
138TAL1_26923725_Chip-Seq_HPCs_Mouse1.07474212
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06983433
140TET1_21490601_ChIP-Seq_MESCs_Mouse1.06362283
141* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06307148
142SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05877590
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05666246
144CMYC_18555785_Chip-Seq_ESCs_Mouse1.04624422
145* GATA4_25053715_ChIP-Seq_YYC3_Human1.04225039
146AHR_22903824_ChIP-Seq_MCF-7_Human1.03875647
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03722376
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02415989
149GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01750725
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00889631
151NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00529316
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00305553
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99811050
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99793908
155TCF7_22412390_ChIP-Seq_EML_Mouse0.99323024
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99099307
157SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98646559
158BCOR_27268052_Chip-Seq_Bcells_Human0.98565052
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98061006
160SMAD4_21799915_ChIP-Seq_A2780_Human0.97917406
161* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97761314
162RNF2_27304074_Chip-Seq_NSC_Mouse0.97701551
163P300_18555785_Chip-Seq_ESCs_Mouse0.97221802
164TCF4_23295773_ChIP-Seq_U87_Human0.96895412
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.96308955
166SOX2_20726797_ChIP-Seq_SW620_Human0.95487325
167SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94957203
168LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94799859
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94672668
170VDR_21846776_ChIP-Seq_THP-1_Human0.94614304
171* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93794932
172* FOXO3_23340844_ChIP-Seq_DLD1_Human0.93615414
173EOMES_21245162_ChIP-Seq_HESCs_Human0.93188930
174* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92895638
175* SA1_27219007_Chip-Seq_Bcells_Human0.92858116
176BCL6_27268052_Chip-Seq_Bcells_Human0.92704585
177PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92672285
178LXR_22158963_ChIP-Seq_LIVER_Mouse0.92291527
179CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92156528
180RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91855516
181GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91612023
182* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91109784
183PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90549081
184TP53_18474530_ChIP-ChIP_U2OS_Human0.89659863
185REST_21632747_ChIP-Seq_MESCs_Mouse0.89437806
186PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89218599
187RUNX2_22187159_ChIP-Seq_PCA_Human0.89176972
188POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88966818
189ESR2_21235772_ChIP-Seq_MCF-7_Human0.88883674
190IRF1_19129219_ChIP-ChIP_H3396_Human0.88451168
191EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88211693
192P53_22387025_ChIP-Seq_ESCs_Mouse0.86408041
193NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86147978
194SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86142841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.15109282
2MP0010234_abnormal_vibrissa_follicle5.00624045
3MP0005670_abnormal_white_adipose3.51125142
4MP0004270_analgesia3.46944144
5MP0003950_abnormal_plasma_membrane3.36555573
6MP0003690_abnormal_glial_cell3.21493837
7MP0003880_abnormal_central_pattern3.15231582
8MP0003136_yellow_coat_color2.97220905
9MP0004264_abnormal_extraembryonic_tissu2.96222252
10MP0002796_impaired_skin_barrier2.83888224
11MP0005171_absent_coat_pigmentation2.71150489
12MP0004782_abnormal_surfactant_physiolog2.65695595
13MP0004742_abnormal_vestibular_system2.57277916
14MP0000462_abnormal_digestive_system2.47010007
15MP0005666_abnormal_adipose_tissue2.44110010
16MP0004885_abnormal_endolymph2.42565279
17MP0003634_abnormal_glial_cell2.41488418
18MP0001485_abnormal_pinna_reflex2.36040254
19MP0001905_abnormal_dopamine_level2.33245130
20MP0003191_abnormal_cellular_cholesterol2.27094458
21MP0003705_abnormal_hypodermis_morpholog2.25642247
22MP0000566_synostosis2.24241176
23MP0005409_darkened_coat_color2.22294974
24MP0002272_abnormal_nervous_system2.21962990
25MP0003566_abnormal_cell_adhesion2.20092841
26MP0001529_abnormal_vocalization2.16104384
27MP0001486_abnormal_startle_reflex2.11325426
28MP0009840_abnormal_foam_cell2.05163150
29MP0000778_abnormal_nervous_system1.98746247
30MP0004043_abnormal_pH_regulation1.97358352
31MP0003329_amyloid_beta_deposits1.96681981
32MP0001849_ear_inflammation1.88364822
33MP0004142_abnormal_muscle_tone1.86425350
34MP0005167_abnormal_blood-brain_barrier1.86206243
35MP0000537_abnormal_urethra_morphology1.84190131
36MP0002098_abnormal_vibrissa_morphology1.83602965
37MP0005451_abnormal_body_composition1.83271503
38MP0000383_abnormal_hair_follicle1.82688782
39MP0010678_abnormal_skin_adnexa1.81420148
40MP0003453_abnormal_keratinocyte_physiol1.79798169
41MP0005375_adipose_tissue_phenotype1.79330104
42MP0002734_abnormal_mechanical_nocicepti1.78147993
43MP0005083_abnormal_biliary_tract1.78018388
44MP0002229_neurodegeneration1.76905807
45MP0004185_abnormal_adipocyte_glucose1.76659065
46MP0005501_abnormal_skin_physiology1.74863248
47MP0001661_extended_life_span1.71097315
48MP0001879_abnormal_lymphatic_vessel1.68899485
49MP0002064_seizures1.64705682
50MP0005165_increased_susceptibility_to1.64371770
51MP0004858_abnormal_nervous_system1.62034875
52MP0001986_abnormal_taste_sensitivity1.59023072
53MP0003632_abnormal_nervous_system1.56776211
54MP0000751_myopathy1.53324405
55MP0002139_abnormal_hepatobiliary_system1.50823979
56MP0001346_abnormal_lacrimal_gland1.48150213
57MP0010368_abnormal_lymphatic_system1.46477354
58MP0005551_abnormal_eye_electrophysiolog1.44248867
59MP0010030_abnormal_orbit_morphology1.44027534
60MP0004381_abnormal_hair_follicle1.41809895
61MP0001727_abnormal_embryo_implantation1.41300082
62MP0005410_abnormal_fertilization1.41236105
63MP0004134_abnormal_chest_morphology1.39839359
64MP0001299_abnormal_eye_distance/1.38523016
65MP0001440_abnormal_grooming_behavior1.35369118
66MP0000343_altered_response_to1.33838304
67MP0000858_altered_metastatic_potential1.32216845
68MP0005023_abnormal_wound_healing1.31734818
69MP0005365_abnormal_bile_salt1.31053815
70MP0009745_abnormal_behavioral_response1.29210769
71MP0002882_abnormal_neuron_morphology1.27598861
72MP0000955_abnormal_spinal_cord1.25715970
73MP0002877_abnormal_melanocyte_morpholog1.24497374
74MP0003195_calcinosis1.23409593
75MP0003075_altered_response_to1.22539623
76MP0002896_abnormal_bone_mineralization1.22353318
77MP0004147_increased_porphyrin_level1.21936775
78MP0009046_muscle_twitch1.21272397
79MP0001963_abnormal_hearing_physiology1.21223443
80MP0004272_abnormal_basement_membrane1.20649794
81MP0001666_abnormal_nutrient_absorption1.20618837
82MP0000678_abnormal_parathyroid_gland1.20306220
83MP0004859_abnormal_synaptic_plasticity1.20237868
84MP0010352_gastrointestinal_tract_polyps1.18584817
85MP0009780_abnormal_chondrocyte_physiolo1.18162740
86MP0005408_hypopigmentation1.17366747
87MP0006072_abnormal_retinal_apoptosis1.16576921
88MP0005166_decreased_susceptibility_to1.15503355
89MP0001881_abnormal_mammary_gland1.15072259
90MP0004019_abnormal_vitamin_homeostasis1.14420442
91MP0002752_abnormal_somatic_nervous1.14214417
92MP0003635_abnormal_synaptic_transmissio1.14154019
93MP0005423_abnormal_somatic_nervous1.13313093
94MP0002295_abnormal_pulmonary_circulatio1.12804025
95MP0005623_abnormal_meninges_morphology1.12623730
96MP0005248_abnormal_Harderian_gland1.11556047
97MP0004233_abnormal_muscle_weight1.10712229
98MP0002971_abnormal_brown_adipose1.10632092
99MP0008260_abnormal_autophagy1.10607276
100MP0002733_abnormal_thermal_nociception1.09734592
101MP0005076_abnormal_cell_differentiation1.09022873
102MP0003279_aneurysm1.08668710
103MP0000762_abnormal_tongue_morphology1.08198921
104MP0001970_abnormal_pain_threshold1.07896600
105MP0003938_abnormal_ear_development1.07777968
106MP0003091_abnormal_cell_migration1.06854738
107MP0000627_abnormal_mammary_gland1.06387281
108MP0003806_abnormal_nucleotide_metabolis1.04469388
109MP0006138_congestive_heart_failure1.04432195
110MP0000647_abnormal_sebaceous_gland1.04296467
111MP0002066_abnormal_motor_capabilities/c1.03939147
112MP0002067_abnormal_sensory_capabilities1.03725716
113MP0003631_nervous_system_phenotype1.03453841
114MP0001216_abnormal_epidermal_layer1.03262688
115MP0000249_abnormal_blood_vessel1.01861759
116MP0008875_abnormal_xenobiotic_pharmacok1.00716060
117MP0003828_pulmonary_edema0.99591386
118MP0003937_abnormal_limbs/digits/tail_de0.99525001
119MP0002572_abnormal_emotion/affect_behav0.98932587
120MP0001664_abnormal_digestion0.98439562
121MP0004510_myositis0.97741656
122MP0003878_abnormal_ear_physiology0.97405252
123MP0005377_hearing/vestibular/ear_phenot0.97405252
124MP0000026_abnormal_inner_ear0.97059975
125MP0004924_abnormal_behavior0.96637854
126MP0005386_behavior/neurological_phenoty0.96637854
127MP0005253_abnormal_eye_physiology0.95637109
128MP0008004_abnormal_stomach_pH0.95533411
129MP0005195_abnormal_posterior_eye0.94013988
130MP0005379_endocrine/exocrine_gland_phen0.93165548
131MP0000013_abnormal_adipose_tissue0.92243251
132MP0001873_stomach_inflammation0.90834107
133MP0000767_abnormal_smooth_muscle0.90335551
134MP0009643_abnormal_urine_homeostasis0.89694213
135MP0009115_abnormal_fat_cell0.89675928
136MP0000467_abnormal_esophagus_morphology0.89126192
137MP0000477_abnormal_intestine_morphology0.89000943
138MP0001502_abnormal_circadian_rhythm0.88161269
139MP0008569_lethality_at_weaning0.87312485
140MP0002249_abnormal_larynx_morphology0.87294241
141MP0000747_muscle_weakness0.85911833
142MP0002735_abnormal_chemical_nociception0.85752987
143MP0004145_abnormal_muscle_electrophysio0.85662494
144MP0005595_abnormal_vascular_smooth0.82640227
145MP0000003_abnormal_adipose_tissue0.81075542
146MP0000377_abnormal_hair_follicle0.80839841
147MP0003633_abnormal_nervous_system0.80701791
148MP0001851_eye_inflammation0.80615937
149MP0005645_abnormal_hypothalamus_physiol0.79443660
150MP0001968_abnormal_touch/_nociception0.79356063
151MP0000372_irregular_coat_pigmentation0.78168682
152MP0000750_abnormal_muscle_regeneration0.77766509
153MP0010155_abnormal_intestine_physiology0.77197258
154MP0000681_abnormal_thyroid_gland0.76956664
155MP0000579_abnormal_nail_morphology0.76472533
156MP0001765_abnormal_ion_homeostasis0.75976859
157MP0002063_abnormal_learning/memory/cond0.75368192
158MP0002998_abnormal_bone_remodeling0.74621959
159MP0002118_abnormal_lipid_homeostasis0.74578832
160MP0000604_amyloidosis0.74303524
161MP0005058_abnormal_lysosome_morphology0.74242595
162MP0002933_joint_inflammation0.73479335
163MP0003638_abnormal_response/metabolism_0.73463497
164MP0005085_abnormal_gallbladder_physiolo0.73349346
165MP0009278_abnormal_bone_marrow0.73291378
166MP0000465_gastrointestinal_hemorrhage0.72229704
167MP0002653_abnormal_ependyma_morphology0.72095946
168MP0001177_atelectasis0.70897302
169MP0003879_abnormal_hair_cell0.70408416
170MP0002938_white_spotting0.69953691
171MP0002060_abnormal_skin_morphology0.69915848
172MP0002909_abnormal_adrenal_gland0.69538414
173MP0010771_integument_phenotype0.69271831
174MP0002736_abnormal_nociception_after0.69000503
175MP0005360_urolithiasis0.68687437
176MP0002152_abnormal_brain_morphology0.68681316
177MP0000534_abnormal_ureter_morphology0.67515080
178MP0010329_abnormal_lipoprotein_level0.66154979
179MP0005381_digestive/alimentary_phenotyp0.65466487
180MP0000613_abnormal_salivary_gland0.64577876
181MP0000631_abnormal_neuroendocrine_gland0.63904168
182MP0006276_abnormal_autonomic_nervous0.63847694

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.90986598
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.90986598
3Neurofibrillary tangles (HP:0002185)5.79156814
4Parakeratosis (HP:0001036)5.12902661
5Sensory axonal neuropathy (HP:0003390)4.97278044
6Abnormality of the corticospinal tract (HP:0002492)4.23479479
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.16296659
8Peripheral hypomyelination (HP:0007182)3.95746517
9Cerebral inclusion bodies (HP:0100314)3.87787796
10Axonal loss (HP:0003447)3.87234385
11Distal lower limb muscle weakness (HP:0009053)3.42176115
12Onion bulb formation (HP:0003383)3.42044480
13Alacrima (HP:0000522)3.28080716
14Abnormality of the nasal mucosa (HP:0000433)3.26942152
15Akinesia (HP:0002304)3.26614517
16Right ventricular cardiomyopathy (HP:0011663)3.22434687
17Congenital ichthyosiform erythroderma (HP:0007431)3.10809116
18Cervical subluxation (HP:0003308)3.10582975
19Flat acetabular roof (HP:0003180)3.06802332
20Hyperactive renin-angiotensin system (HP:0000841)3.06372265
21Short nail (HP:0001799)3.03929714
22Cerebral hypomyelination (HP:0006808)3.01013125
23Spastic gait (HP:0002064)2.98882624
24Supranuclear gaze palsy (HP:0000605)2.97624324
25Abnormal auditory evoked potentials (HP:0006958)2.93522783
26Intention tremor (HP:0002080)2.92394676
27Hemorrhage of the eye (HP:0011885)2.90827669
28Acanthosis nigricans (HP:0000956)2.86137614
29Anteriorly placed anus (HP:0001545)2.84810451
30Systemic lupus erythematosus (HP:0002725)2.81246393
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.80912994
32Vertebral compression fractures (HP:0002953)2.77040384
33Thickened helices (HP:0000391)2.76646108
34Autoamputation (HP:0001218)2.75037881
35Abnormality of the distal phalanges of the toes (HP:0010182)2.74435813
36Distal upper limb amyotrophy (HP:0007149)2.74049655
37Upper limb amyotrophy (HP:0009129)2.74049655
38Increased circulating renin level (HP:0000848)2.73867119
39Nuclear cataract (HP:0100018)2.72082913
40Hypomagnesemia (HP:0002917)2.68913739
41Esophageal varix (HP:0002040)2.68305985
42Abnormality of liposaccharide metabolism (HP:0010968)2.68147635
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.68147635
44Abnormality of glycolipid metabolism (HP:0010969)2.68147635
45Premature skin wrinkling (HP:0100678)2.66794270
46Dysostosis multiplex (HP:0000943)2.63297588
47Hypoplastic pelvis (HP:0008839)2.62480929
48Split foot (HP:0001839)2.62292157
49Arterial tortuosity (HP:0005116)2.62178473
50Decreased lacrimation (HP:0000633)2.62147364
51Retinal dysplasia (HP:0007973)2.61993166
52Urinary glycosaminoglycan excretion (HP:0003541)2.57992569
53Mucopolysacchariduria (HP:0008155)2.57992569
54Aplasia involving bones of the upper limbs (HP:0009823)2.57930427
55Aplasia of the phalanges of the hand (HP:0009802)2.57930427
56Aplasia involving bones of the extremities (HP:0009825)2.57930427
57Dysmetria (HP:0001310)2.55553371
58Interstitial pulmonary disease (HP:0006530)2.53647930
59Termporal pattern (HP:0011008)2.48543821
60Insidious onset (HP:0003587)2.48543821
61Leukodystrophy (HP:0002415)2.47367159
62Abnormality of polysaccharide metabolism (HP:0011012)2.46703255
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46703255
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46703255
65Spastic paraparesis (HP:0002313)2.45678848
66Malnutrition (HP:0004395)2.44990906
67Cerebral hemorrhage (HP:0001342)2.44128822
68Growth hormone excess (HP:0000845)2.42747378
69Distal lower limb amyotrophy (HP:0008944)2.40759679
70Infantile muscular hypotonia (HP:0008947)2.38313283
71Subcapsular cataract (HP:0000523)2.37969117
72Chronic bronchitis (HP:0004469)2.37882423
73J-shaped sella turcica (HP:0002680)2.37793307
74Adrenal hypoplasia (HP:0000835)2.36298460
75Pheochromocytoma (HP:0002666)2.32732140
76Cupped ear (HP:0000378)2.32591657
77Vacuolated lymphocytes (HP:0001922)2.29843446
78Cerebral aneurysm (HP:0004944)2.29058822
79Stridor (HP:0010307)2.28972655
80Absent septum pellucidum (HP:0001331)2.28908700
81Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27572835
82Scanning speech (HP:0002168)2.27194680
83Lymphangioma (HP:0100764)2.26555470
84Mildly elevated creatine phosphokinase (HP:0008180)2.25466242
85Nasal polyposis (HP:0100582)2.24944574
86Abdominal distention (HP:0003270)2.24550658
87Segmental peripheral demyelination/remyelination (HP:0003481)2.22870123
88Slow saccadic eye movements (HP:0000514)2.22462264
89Vascular tortuosity (HP:0004948)2.22107272
90Asymmetric septal hypertrophy (HP:0001670)2.21430011
91Increased serum pyruvate (HP:0003542)2.20997870
92Abnormality of glycolysis (HP:0004366)2.20997870
93Rhinitis (HP:0012384)2.20827868
94Synostosis involving the elbow (HP:0003938)2.20565743
95Humeroradial synostosis (HP:0003041)2.20565743
96White forelock (HP:0002211)2.19636118
97Congenital sensorineural hearing impairment (HP:0008527)2.19593509
98Thin bony cortex (HP:0002753)2.19513872
99Increased connective tissue (HP:0009025)2.18094192
100Patchy hypopigmentation of hair (HP:0011365)2.18074865
101Megalencephaly (HP:0001355)2.17634108
102Spinal cord compression (HP:0002176)2.17573449
103Neuroendocrine neoplasm (HP:0100634)2.16543902
104Coronal craniosynostosis (HP:0004440)2.15252216
105Metabolic alkalosis (HP:0200114)2.14199584
106Loss of speech (HP:0002371)2.12744073
107Glomerulosclerosis (HP:0000096)2.12718098
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12512266
109Bulbar palsy (HP:0001283)2.12498298
110Pili torti (HP:0003777)2.12245175
111Polar cataract (HP:0010696)2.11927560
112Broad face (HP:0000283)2.10781068
113Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10570919
114Achilles tendon contracture (HP:0001771)2.09711858
115Flattened epiphyses (HP:0003071)2.09613126
116Tetraparesis (HP:0002273)2.08950440
117Hypoplasia of the iris (HP:0007676)2.08174585
118Focal segmental glomerulosclerosis (HP:0000097)2.07526653
119Hyperacusis (HP:0010780)2.07472836
120Barrel-shaped chest (HP:0001552)2.07115034
121Abnormality of magnesium homeostasis (HP:0004921)2.06934664
122Osteolytic defects of the hand bones (HP:0009699)2.06346127
123Osteolytic defects of the phalanges of the hand (HP:0009771)2.06346127
124Hypertriglyceridemia (HP:0002155)2.06220372
125Abnormal respiratory motile cilium physiology (HP:0012261)2.05907563
126Hypokalemic alkalosis (HP:0001949)2.02417887
127Premature rupture of membranes (HP:0001788)2.01569587
128Protrusio acetabuli (HP:0003179)2.01141306
129Visceral angiomatosis (HP:0100761)2.00801631
130Hepatosplenomegaly (HP:0001433)1.99779663
131Renal Fanconi syndrome (HP:0001994)1.99550767
132Abnormal respiratory epithelium morphology (HP:0012253)1.98485933
133Abnormal respiratory motile cilium morphology (HP:0005938)1.98485933
134Hand muscle atrophy (HP:0009130)1.98187861
135Abnormality of complement system (HP:0005339)1.97984287
136Vaginal atresia (HP:0000148)1.96595020
137Hydroxyprolinuria (HP:0003080)1.95980990
138Abnormality of proline metabolism (HP:0010907)1.95980990
139Diaphragmatic weakness (HP:0009113)1.95262139
140Hyperparathyroidism (HP:0000843)1.95102944
141Trismus (HP:0000211)1.93898263
142Partial duplication of thumb phalanx (HP:0009944)1.92785894
143Abnormality of the septum pellucidum (HP:0007375)1.92125252
144Complement deficiency (HP:0004431)1.91616496
145Esophageal atresia (HP:0002032)1.89815739
146Amyloidosis (HP:0011034)1.89587623
147Hypokinesia (HP:0002375)1.89464296
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89441330
149Abnormality of the Achilles tendon (HP:0005109)1.88504899
150Bone pain (HP:0002653)1.87995395
151Genital tract atresia (HP:0001827)1.87544160
152Abnormality of carpal bone ossification (HP:0006257)1.86373870
153Morphological abnormality of the inner ear (HP:0011390)1.85672493
154Abnormal vertebral ossification (HP:0100569)1.85584493
155Diminished movement (HP:0002374)1.85008983
156Anomalous pulmonary venous return (HP:0010772)1.84993163
157Increased cerebral lipofuscin (HP:0011813)1.84868952
158Hemangiomatosis (HP:0007461)1.84698273
159Glucose intolerance (HP:0000833)1.83690087
160CNS hypomyelination (HP:0003429)1.82495502
161Clumsiness (HP:0002312)1.82170661
162Abnormality of the middle phalanges of the toes (HP:0010183)1.82155641
163Insulin resistance (HP:0000855)1.82039505
164Male infertility (HP:0003251)1.80624595
165Wide cranial sutures (HP:0010537)1.80344499
166Ankle clonus (HP:0011448)1.80001695
167Glomerulonephritis (HP:0000099)1.79230220
168Foot dorsiflexor weakness (HP:0009027)1.78296342
169Partial agenesis of the corpus callosum (HP:0001338)1.77189177
170Increased corneal curvature (HP:0100692)1.76476079
171Keratoconus (HP:0000563)1.76476079
172Steppage gait (HP:0003376)1.76070538
173Ileus (HP:0002595)1.75771782
174Abnormality of the periventricular white matter (HP:0002518)1.75758889
175Mixed hearing impairment (HP:0000410)1.75620483
176Intrahepatic cholestasis (HP:0001406)1.74887873
177Poor speech (HP:0002465)1.74261115
178Polygenic inheritance (HP:0010982)1.73968764
179Absent/shortened dynein arms (HP:0200106)1.73818128
180Dynein arm defect of respiratory motile cilia (HP:0012255)1.73818128
181Neonatal death (HP:0003811)1.73638068
182Cone-rod dystrophy (HP:0000548)1.73587278
183Decreased motor nerve conduction velocity (HP:0003431)1.73213572
184Prolonged neonatal jaundice (HP:0006579)1.73033335
185Abolished electroretinogram (ERG) (HP:0000550)1.72859888
186Lower limb muscle weakness (HP:0007340)1.72831319
187Methylmalonic acidemia (HP:0002912)1.72247893
188Abnormal ciliary motility (HP:0012262)1.71073312
189Bell-shaped thorax (HP:0001591)1.69508149
190Septo-optic dysplasia (HP:0100842)1.69147917
191Gowers sign (HP:0003391)1.68212132
192Abnormality of the pulmonary veins (HP:0011718)1.67749207
193Stenosis of the external auditory canal (HP:0000402)1.66455196
194Paraparesis (HP:0002385)1.66235625
195Erythroderma (HP:0001019)1.62640497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.07752776
2STK396.40129275
3OXSR14.65485414
4MST1R4.20099365
5TESK14.05975642
6TRIB33.95468953
7BCR3.06303659
8TNIK2.99183981
9EPHB12.94653295
10WNK42.87609857
11MET2.81026842
12SIK12.55740371
13RIPK12.43346246
14LMTK22.43137063
15ERN12.38628468
16PRPF4B2.32566578
17PAK42.31356061
18CDK192.25643607
19NME22.17212432
20NEK62.13062754
21PBK2.11879588
22PKN12.10564313
23FGFR22.10382325
24WNK11.95323277
25IRAK31.93295474
26MAP3K121.89481030
27ICK1.85483437
28MST41.82830947
29LIMK11.77753442
30PKN21.72641563
31MAPKAPK31.68528506
32MAPKAPK51.64740790
33CSNK1A1L1.58791286
34CSNK1G31.57534668
35UHMK11.56997892
36CASK1.54083764
37FER1.52538989
38NTRK11.51744945
39ROCK21.46942864
40CAMK2B1.46335351
41FGR1.42746890
42PNCK1.36320529
43ILK1.35804613
44MAPK151.35347451
45SMG11.31603097
46PTK61.29871164
47CAMK2D1.27466285
48CLK11.27322315
49CSNK1G11.23660264
50EPHA41.20814851
51PAK61.14964381
52CSNK1G21.12121370
53TGFBR21.11070597
54IRAK21.09055891
55MAP3K31.05691679
56SGK2231.05161934
57SGK4941.05161934
58PAK31.03819181
59LATS21.03793994
60BMPR1B1.00024403
61RPS6KB20.96656967
62PRKG20.96653936
63MYLK0.95320809
64PDGFRA0.92940031
65CAMK2G0.92844650
66ABL20.90428056
67PRKCQ0.89134029
68SCYL20.87829846
69MAP3K110.85317405
70TRPM70.84457843
71IRAK10.81199899
72FGFR40.79805318
73SIK30.79074354
74INSRR0.78972986
75CAMK2A0.77835081
76DYRK20.77002695
77PRKCE0.76895101
78EEF2K0.74521695
79CDK140.73873241
80MARK20.73299196
81TBK10.72844207
82ERBB40.72538449
83TYRO30.71992196
84LRRK20.69235689
85CDK50.66908416
86TIE10.65523256
87DMPK0.61692709
88MAP2K20.60726886
89MUSK0.60116271
90TESK20.59646307
91BMX0.59552144
92MAP3K20.59430196
93PRKD30.57352373
94CDK150.57236953
95STK380.56842014
96PHKG20.56806235
97PHKG10.56806235
98DAPK10.56515173
99MARK10.56305926
100PRKCI0.55962775
101PRKD10.55878786
102CDK80.55336708
103EPHB20.54753931
104MAP3K10.54672669
105ARAF0.53934342
106CDK180.53520947
107PDPK10.52326169
108CDK11A0.50818286
109STK160.50459747
110PDGFRB0.50301060
111FYN0.49997797
112GRK10.49885519
113RPS6KA20.49279032
114PIM20.49180210
115ROCK10.49077635
116DAPK30.46020142
117NUAK10.45785037
118NME10.45776099
119CDK90.45085994
120RPS6KA50.44443970
121CSNK1A10.43350359
122PRKG10.43347850
123MTOR0.42515574
124GSK3A0.39763262
125PRKAA20.38840004
126PRKCH0.38805636
127HIPK20.38151430
128CDC42BPA0.38047958
129BCKDK0.38046329
130MAPK130.38022892
131ADRBK20.37313451
132SRC0.37111954
133ITK0.36521727
134RET0.36346777
135TAOK20.34817017
136TAOK10.34455798
137MAP2K10.33966788
138CSK0.33814453
139PIK3CA0.33715524
140CAMK1G0.32981387
141MATK0.31022515
142PAK10.30742489
143MAPK70.30248953
144PTK2B0.29934965
145LATS10.29476369
146ZAP700.29244200
147PRKACB0.29009708
148PRKACA0.29004216
149CSNK1D0.28884313
150INSR0.28535052
151ERBB20.27953556
152MAPKAPK20.26150876
153MKNK10.25821345
154PRKD20.25699763
155AKT20.25588069
156BMPR20.25094085
157MAP3K70.23337788
158KDR0.23130029
159PTK20.22955044
160TTN0.22447137
161KSR20.22363127
162DDR20.21864904
163MAP3K90.20908463

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.84337474
2Steroid biosynthesis_Homo sapiens_hsa001004.52291090
3Fatty acid elongation_Homo sapiens_hsa000624.05657168
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.75527971
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.22569341
6Ether lipid metabolism_Homo sapiens_hsa005653.12583230
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.01374646
8Protein export_Homo sapiens_hsa030602.91557936
9Other glycan degradation_Homo sapiens_hsa005112.83295147
10Phenylalanine metabolism_Homo sapiens_hsa003602.81982306
11Sulfur metabolism_Homo sapiens_hsa009202.80191775
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.57019638
13Fructose and mannose metabolism_Homo sapiens_hsa000512.44651146
14Sphingolipid metabolism_Homo sapiens_hsa006002.17813598
15Oxidative phosphorylation_Homo sapiens_hsa001902.15406487
16Galactose metabolism_Homo sapiens_hsa000522.12747796
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11033222
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04309012
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93158681
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85671545
21Axon guidance_Homo sapiens_hsa043601.84028376
22Linoleic acid metabolism_Homo sapiens_hsa005911.75838926
23PPAR signaling pathway_Homo sapiens_hsa033201.75821195
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65292534
25Pentose phosphate pathway_Homo sapiens_hsa000301.64072480
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59093101
27Tyrosine metabolism_Homo sapiens_hsa003501.56272248
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56066750
29Sulfur relay system_Homo sapiens_hsa041221.52859891
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47845517
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47327991
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.44028038
33Histidine metabolism_Homo sapiens_hsa003401.42401210
34Butanoate metabolism_Homo sapiens_hsa006501.40543653
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40362409
36Vibrio cholerae infection_Homo sapiens_hsa051101.39782101
37Alzheimers disease_Homo sapiens_hsa050101.38830445
38Parkinsons disease_Homo sapiens_hsa050121.36371511
39beta-Alanine metabolism_Homo sapiens_hsa004101.32377272
40Renin-angiotensin system_Homo sapiens_hsa046141.31265609
41Vitamin B6 metabolism_Homo sapiens_hsa007501.29698205
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26614366
43Serotonergic synapse_Homo sapiens_hsa047261.25489876
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20804917
45Tight junction_Homo sapiens_hsa045301.16174243
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15321270
47Arginine and proline metabolism_Homo sapiens_hsa003301.14949278
48Notch signaling pathway_Homo sapiens_hsa043301.12076105
49Arginine biosynthesis_Homo sapiens_hsa002201.09473651
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07976354
51Collecting duct acid secretion_Homo sapiens_hsa049661.07755375
52Arachidonic acid metabolism_Homo sapiens_hsa005901.06112776
53Biosynthesis of amino acids_Homo sapiens_hsa012301.03365055
54Adherens junction_Homo sapiens_hsa045201.03017074
55Renal cell carcinoma_Homo sapiens_hsa052111.02977018
56Carbon metabolism_Homo sapiens_hsa012001.02512613
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02412858
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.01346796
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99614804
60Fatty acid degradation_Homo sapiens_hsa000710.98478418
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98455841
62Thyroid cancer_Homo sapiens_hsa052160.97269645
63GABAergic synapse_Homo sapiens_hsa047270.94646602
64Glutamatergic synapse_Homo sapiens_hsa047240.93972481
65AMPK signaling pathway_Homo sapiens_hsa041520.92669247
66Glutathione metabolism_Homo sapiens_hsa004800.89499262
67Starch and sucrose metabolism_Homo sapiens_hsa005000.88678076
68Mineral absorption_Homo sapiens_hsa049780.88127596
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87442623
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84839664
71Rheumatoid arthritis_Homo sapiens_hsa053230.83943241
72Fatty acid metabolism_Homo sapiens_hsa012120.83698010
73Bile secretion_Homo sapiens_hsa049760.83670752
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83242326
75Prion diseases_Homo sapiens_hsa050200.83208192
76Hepatitis C_Homo sapiens_hsa051600.81947105
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.80511909
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80280978
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80185934
80Long-term depression_Homo sapiens_hsa047300.79765560
81Morphine addiction_Homo sapiens_hsa050320.78722230
82Focal adhesion_Homo sapiens_hsa045100.78204389
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77824887
84Phototransduction_Homo sapiens_hsa047440.76801893
85Huntingtons disease_Homo sapiens_hsa050160.76672369
86Autoimmune thyroid disease_Homo sapiens_hsa053200.75656244
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.75390283
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75352163
89Dorso-ventral axis formation_Homo sapiens_hsa043200.73974175
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73799391
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.72775626
92ECM-receptor interaction_Homo sapiens_hsa045120.71752657
93Lysosome_Homo sapiens_hsa041420.71657063
94Ovarian steroidogenesis_Homo sapiens_hsa049130.71113125
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.70937196
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.70616818
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.69836127
98Ras signaling pathway_Homo sapiens_hsa040140.69324896
99Pyruvate metabolism_Homo sapiens_hsa006200.69047030
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.68683647
101Pancreatic secretion_Homo sapiens_hsa049720.68162520
102Salmonella infection_Homo sapiens_hsa051320.66547792
103Insulin signaling pathway_Homo sapiens_hsa049100.66084999
104Endocytosis_Homo sapiens_hsa041440.66001120
105Fatty acid biosynthesis_Homo sapiens_hsa000610.65703033
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64885701
107Bladder cancer_Homo sapiens_hsa052190.64449457
108Cocaine addiction_Homo sapiens_hsa050300.63484686
109Malaria_Homo sapiens_hsa051440.63381124
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62265009
111N-Glycan biosynthesis_Homo sapiens_hsa005100.61690171
112Folate biosynthesis_Homo sapiens_hsa007900.61552679
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61381051
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.60739197
115Propanoate metabolism_Homo sapiens_hsa006400.59679899
116Cardiac muscle contraction_Homo sapiens_hsa042600.59677105
117HIF-1 signaling pathway_Homo sapiens_hsa040660.55389120
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55223149
119Proteoglycans in cancer_Homo sapiens_hsa052050.54137806
120Peroxisome_Homo sapiens_hsa041460.52774136
121Insulin resistance_Homo sapiens_hsa049310.52724698
122Amoebiasis_Homo sapiens_hsa051460.52615717
123VEGF signaling pathway_Homo sapiens_hsa043700.51057576
124Taste transduction_Homo sapiens_hsa047420.50316856
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49371140
126ErbB signaling pathway_Homo sapiens_hsa040120.48285976
127Metabolic pathways_Homo sapiens_hsa011000.47655112
128Salivary secretion_Homo sapiens_hsa049700.46437848
129Circadian entrainment_Homo sapiens_hsa047130.45831111
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45498126
131Phagosome_Homo sapiens_hsa041450.45060447
132Gastric acid secretion_Homo sapiens_hsa049710.44216397
133Vitamin digestion and absorption_Homo sapiens_hsa049770.41694153
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41264284
135Hedgehog signaling pathway_Homo sapiens_hsa043400.41226524
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41176348
137Cholinergic synapse_Homo sapiens_hsa047250.40885968
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39367933
139Protein digestion and absorption_Homo sapiens_hsa049740.38911536
140Pertussis_Homo sapiens_hsa051330.38772795
141Choline metabolism in cancer_Homo sapiens_hsa052310.38309956
142Chemical carcinogenesis_Homo sapiens_hsa052040.37651983
143Fat digestion and absorption_Homo sapiens_hsa049750.36964897
144Glycerolipid metabolism_Homo sapiens_hsa005610.36833651
145Insulin secretion_Homo sapiens_hsa049110.36302058
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34853313
147Endometrial cancer_Homo sapiens_hsa052130.34452336
148Regulation of autophagy_Homo sapiens_hsa041400.34343064
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32976335
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31103841
151Dopaminergic synapse_Homo sapiens_hsa047280.30357089
152Gap junction_Homo sapiens_hsa045400.28731715
153Retinol metabolism_Homo sapiens_hsa008300.28367857
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26902044
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26337214
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23636320
157Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23339527

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