TSPAN16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.85221650
2acrosome reaction (GO:0007340)7.13944797
3cell wall macromolecule metabolic process (GO:0044036)7.10841932
4fusion of sperm to egg plasma membrane (GO:0007342)6.43821206
5sperm capacitation (GO:0048240)6.28046598
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.06502399
7protein targeting to Golgi (GO:0000042)5.97055113
8establishment of protein localization to Golgi (GO:0072600)5.79674010
9retrograde transport, vesicle recycling within Golgi (GO:0000301)5.59517612
10phosphatidylethanolamine biosynthetic process (GO:0006646)5.58021557
11spermatid development (GO:0007286)5.23709304
12phosphatidylethanolamine metabolic process (GO:0046337)5.17049669
13spermatid nucleus differentiation (GO:0007289)5.10534298
14DNA packaging (GO:0006323)5.08959330
15chromosome condensation (GO:0030261)5.04350540
16multicellular organism reproduction (GO:0032504)4.98009716
17single strand break repair (GO:0000012)4.92434310
18modulation by symbiont of host immune response (GO:0052553)4.85877236
19positive regulation by symbiont of host defense response (GO:0052509)4.85877236
20modulation by symbiont of host defense response (GO:0052031)4.85877236
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.85877236
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.85877236
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.85877236
24rRNA methylation (GO:0031167)4.77831927
25microtubule depolymerization (GO:0007019)4.74216250
26production of molecular mediator involved in inflammatory response (GO:0002532)4.73550818
27plasma membrane fusion (GO:0045026)4.68995901
28protein polyglutamylation (GO:0018095)4.57306680
29negative regulation of inclusion body assembly (GO:0090084)4.55045768
30response to pheromone (GO:0019236)4.49676961
31cell wall macromolecule catabolic process (GO:0016998)4.46940262
32reproduction (GO:0000003)4.42505905
33cilium or flagellum-dependent cell motility (GO:0001539)4.39311811
34sperm-egg recognition (GO:0035036)4.38606057
35centriole replication (GO:0007099)4.37170971
36cellular extravasation (GO:0045123)4.35635839
37RNA destabilization (GO:0050779)4.22929617
38macrophage activation involved in immune response (GO:0002281)4.21469784
39protein localization to Golgi apparatus (GO:0034067)4.18494265
40regulation of T-helper 2 cell differentiation (GO:0045628)4.12128807
41microtubule severing (GO:0051013)4.08074217
42microglial cell activation (GO:0001774)4.07437749
43spermatogenesis (GO:0007283)4.06904697
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.06743006
45male gamete generation (GO:0048232)4.05236100
46axonemal dynein complex assembly (GO:0070286)3.97763244
47microtubule polymerization or depolymerization (GO:0031109)3.97145500
48regulation of interferon-beta biosynthetic process (GO:0045357)3.93138036
49calcium ion-dependent exocytosis (GO:0017156)3.83673039
50detection of molecule of bacterial origin (GO:0032490)3.81669440
51rRNA modification (GO:0000154)3.75305967
52cell-cell recognition (GO:0009988)3.72685793
53gamete generation (GO:0007276)3.70555738
54centriole assembly (GO:0098534)3.67122805
55regulation of cilium movement (GO:0003352)3.60458688
56regulation of Rab GTPase activity (GO:0032313)3.60367799
57positive regulation of Rab GTPase activity (GO:0032851)3.60367799
58sexual reproduction (GO:0019953)3.58762157
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56699994
60negative regulation of cell killing (GO:0031342)3.56699994
61neutrophil activation involved in immune response (GO:0002283)3.54987110
62binding of sperm to zona pellucida (GO:0007339)3.52789509
63positive regulation of gamma-delta T cell activation (GO:0046645)3.47263420
64macrophage activation (GO:0042116)3.45574260
65neutrophil mediated immunity (GO:0002446)3.42505033
66regulation of gamma-delta T cell activation (GO:0046643)3.39440468
67regulation of B cell receptor signaling pathway (GO:0050855)3.38790843
68myeloid cell activation involved in immune response (GO:0002275)3.35267078
69negative regulation of Rho protein signal transduction (GO:0035024)3.33779412
70response to peptidoglycan (GO:0032494)3.28871610
71regulation of gamma-delta T cell differentiation (GO:0045586)3.26198991
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25788467
73response to host immune response (GO:0052572)3.25788467
74single fertilization (GO:0007338)3.25756285
75epithelial cilium movement (GO:0003351)3.25686629
76neutrophil activation (GO:0042119)3.23427750
77positive regulation of chemokine secretion (GO:0090197)3.22225634
78mast cell degranulation (GO:0043303)3.20065727
79mast cell activation involved in immune response (GO:0002279)3.20065727
80leukocyte migration involved in inflammatory response (GO:0002523)3.16781471
81detection of other organism (GO:0098543)3.14239540
82positive regulation of toll-like receptor signaling pathway (GO:0034123)3.13751539
83leukocyte degranulation (GO:0043299)3.11918452
84detection of external biotic stimulus (GO:0098581)3.11690215
85regulation of mast cell degranulation (GO:0043304)3.08846818
86positive regulation of mast cell activation (GO:0033005)3.06990771
87regulation of inclusion body assembly (GO:0090083)3.01899210
88motile cilium assembly (GO:0044458)2.98702767
89regulation of mast cell activation involved in immune response (GO:0033006)2.98495951
90seminiferous tubule development (GO:0072520)2.98441568
91multicellular organismal reproductive process (GO:0048609)2.94773001
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94416643
93germ cell development (GO:0007281)2.92028732
94mast cell activation (GO:0045576)2.90068798
95positive regulation of mast cell degranulation (GO:0043306)2.90002233
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.90002233
97peptidyl-threonine dephosphorylation (GO:0035970)2.89538605
98histone mRNA catabolic process (GO:0071044)2.86408044
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86319224
100regulation of mast cell activation (GO:0033003)2.85262917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.71379090
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.43313829
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.73030107
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.60769312
5EZH2_22144423_ChIP-Seq_EOC_Human2.36077668
6* RUNX_20019798_ChIP-Seq_JUKART_Human2.17797821
7* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.09536193
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04550123
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.97918662
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97918662
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92800162
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86706758
13VDR_24787735_ChIP-Seq_THP-1_Human1.84887126
14SPI1_23127762_ChIP-Seq_K562_Human1.84170567
15DROSHA_22980978_ChIP-Seq_HELA_Human1.80148627
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74793423
17SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70703794
18IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67986957
19CBP_20019798_ChIP-Seq_JUKART_Human1.67986957
20* NANOG_20526341_ChIP-Seq_ESCs_Human1.65676383
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64402242
22BCL6_27268052_Chip-Seq_Bcells_Human1.63174865
23* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.62166402
24SCL_19346495_ChIP-Seq_HPC-7_Human1.58734771
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57037264
26RAC3_21632823_ChIP-Seq_H3396_Human1.54610300
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.53208750
28* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50006470
29GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49922019
30ERA_21632823_ChIP-Seq_H3396_Human1.47706023
31MYB_26560356_Chip-Seq_TH2_Human1.46678441
32ER_23166858_ChIP-Seq_MCF-7_Human1.46512130
33BCOR_27268052_Chip-Seq_Bcells_Human1.44377326
34SMRT_27268052_Chip-Seq_Bcells_Human1.42347798
35* ELF1_20517297_ChIP-Seq_JURKAT_Human1.40056014
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34129218
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33863306
38P300_27268052_Chip-Seq_Bcells_Human1.32980564
39VDR_24763502_ChIP-Seq_THP-1_Human1.32613659
40SPI1_20517297_ChIP-Seq_HL60_Human1.32452401
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31778083
42GATA3_27048872_Chip-Seq_THYMUS_Human1.31008508
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28056738
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27069069
45KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.26052498
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25872668
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25087516
48OCT4_20526341_ChIP-Seq_ESCs_Human1.24937797
49* GATA3_26560356_Chip-Seq_TH2_Human1.24854036
50* TAF2_19829295_ChIP-Seq_ESCs_Human1.24422730
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24410142
52* E2F1_20622854_ChIP-Seq_HELA_Human1.23031079
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22729359
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22615212
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22346598
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21717550
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21618325
58P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18819482
59SMC4_20622854_ChIP-Seq_HELA_Human1.18572084
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.18398519
61CEBPB_22108803_ChIP-Seq_LS180_Human1.16697671
62EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16125184
63* MYC_19829295_ChIP-Seq_ESCs_Human1.15265783
64* ERG_20517297_ChIP-Seq_VCAP_Human1.15196342
65TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.14709338
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.14694524
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13128103
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13103421
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12849769
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11695467
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11632796
72MYB_26560356_Chip-Seq_TH1_Human1.10832428
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.10780720
74P68_20966046_ChIP-Seq_HELA_Human1.10631569
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.09202634
76SPI1_23547873_ChIP-Seq_NB4_Human1.08785930
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08088862
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06538898
79CTCF_20526341_ChIP-Seq_ESCs_Human1.06211456
80* PHF8_20622854_ChIP-Seq_HELA_Human1.06038059
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04745966
82RBPJ_21746931_ChIP-Seq_IB4_Human1.04599950
83* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04279384
84TP63_22573176_ChIP-Seq_HFKS_Human1.03837972
85UTX_26944678_Chip-Seq_JUKART_Human1.03208795
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02318857
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01713257
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00715785
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.00642817
90LXR_22292898_ChIP-Seq_THP-1_Human1.00388401
91OCT1_27270436_Chip-Seq_PROSTATE_Human0.99822133
92GATA3_26560356_Chip-Seq_TH1_Human0.99090474
93AR_25329375_ChIP-Seq_VCAP_Human0.98871500
94OCT4_19829295_ChIP-Seq_ESCs_Human0.98707211
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.98373016
96ETV1_20927104_ChIP-Seq_GIST48_Human0.98283740
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97765421
98CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96483936
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.96083080
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95903147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.87339032
2MP0005377_hearing/vestibular/ear_phenot4.42795473
3MP0003878_abnormal_ear_physiology4.42795473
4MP0003724_increased_susceptibility_to3.79491862
5MP0001835_abnormal_antigen_presentation3.15325587
6MP0003436_decreased_susceptibility_to3.03440733
7MP0003698_abnormal_male_reproductive2.82790163
8MP0001929_abnormal_gametogenesis2.53643649
9MP0002132_abnormal_respiratory_system2.38431550
10MP0002419_abnormal_innate_immunity2.32070431
11MP0003303_peritoneal_inflammation2.26207001
12MP0005670_abnormal_white_adipose2.25477600
13MP0003646_muscle_fatigue2.11446156
14MP0000685_abnormal_immune_system2.09840709
15MP0005310_abnormal_salivary_gland2.09034315
16MP0001800_abnormal_humoral_immune2.05957780
17MP0009785_altered_susceptibility_to2.05328108
18MP0005025_abnormal_response_to2.02063554
19MP0005671_abnormal_response_to1.94999083
20MP0002723_abnormal_immune_serum1.88449420
21MP0009278_abnormal_bone_marrow1.88039444
22MP0000569_abnormal_digit_pigmentation1.73124760
23MP0002420_abnormal_adaptive_immunity1.73118493
24MP0005000_abnormal_immune_tolerance1.70438614
25MP0001819_abnormal_immune_cell1.69518643
26MP0002452_abnormal_antigen_presenting1.65807075
27MP0001533_abnormal_skeleton_physiology1.63904108
28MP0005451_abnormal_body_composition1.61293460
29MP0001348_abnormal_lacrimal_gland1.55483234
30MP0001790_abnormal_immune_system1.54236106
31MP0005387_immune_system_phenotype1.54236106
32MP0009764_decreased_sensitivity_to1.51444716
33MP0002161_abnormal_fertility/fecundity1.47863870
34MP0005397_hematopoietic_system_phenotyp1.45730728
35MP0001545_abnormal_hematopoietic_system1.45730728
36MP0003011_delayed_dark_adaptation1.40986334
37MP0002138_abnormal_hepatobiliary_system1.37719977
38MP0000716_abnormal_immune_system1.30889130
39MP0000678_abnormal_parathyroid_gland1.29481456
40MP0002398_abnormal_bone_marrow1.28280766
41MP0005464_abnormal_platelet_physiology1.25185425
42MP0003828_pulmonary_edema1.23898206
43MP0003172_abnormal_lysosome_physiology1.22018460
44MP0006082_CNS_inflammation1.21158564
45MP0003191_abnormal_cellular_cholesterol1.19447185
46MP0002405_respiratory_system_inflammati1.16445223
47MP0004883_abnormal_blood_vessel1.14380801
48MP0001486_abnormal_startle_reflex1.13452695
49MP0003879_abnormal_hair_cell1.12870652
50MP0002166_altered_tumor_susceptibility1.10507582
51MP0008260_abnormal_autophagy1.09139596
52MP0004510_myositis1.07000617
53MP0002277_abnormal_respiratory_mucosa1.06957099
54MP0001765_abnormal_ion_homeostasis1.06287762
55MP0002148_abnormal_hypersensitivity_rea1.05623864
56MP0002722_abnormal_immune_system1.03814986
57MP0001845_abnormal_inflammatory_respons1.03486116
58MP0008469_abnormal_protein_level0.98297516
59MP0003718_maternal_effect0.97949418
60MP0002429_abnormal_blood_cell0.97184667
61MP0004381_abnormal_hair_follicle0.96940081
62MP0003763_abnormal_thymus_physiology0.95103435
63MP0005164_abnormal_response_to0.94196292
64MP0002210_abnormal_sex_determination0.92812164
65MP0000703_abnormal_thymus_morphology0.92138257
66MP0000689_abnormal_spleen_morphology0.91396339
67MP0002653_abnormal_ependyma_morphology0.89647364
68MP0004947_skin_inflammation0.84608120
69MP0008004_abnormal_stomach_pH0.83650547
70MP0001968_abnormal_touch/_nociception0.82830765
71MP0008877_abnormal_DNA_methylation0.82662753
72MP0005166_decreased_susceptibility_to0.82266802
73MP0001145_abnormal_male_reproductive0.81126527
74MP0003866_abnormal_defecation0.81117223
75MP0000653_abnormal_sex_gland0.78946977
76MP0005551_abnormal_eye_electrophysiolog0.77703425
77MP0004742_abnormal_vestibular_system0.77401442
78MP0001986_abnormal_taste_sensitivity0.76826361
79MP0004484_altered_response_of0.76802428
80MP0001485_abnormal_pinna_reflex0.76062294
81MP0002998_abnormal_bone_remodeling0.75943465
82MP0009765_abnormal_xenobiotic_induced0.75655701
83MP0002928_abnormal_bile_duct0.74577382
84MP0002127_abnormal_cardiovascular_syste0.73938659
85MP0002735_abnormal_chemical_nociception0.72117742
86MP0005167_abnormal_blood-brain_barrier0.72092395
87MP0001963_abnormal_hearing_physiology0.68712104
88MP0009115_abnormal_fat_cell0.68661891
89MP0004130_abnormal_muscle_cell0.68032247
90MP0000249_abnormal_blood_vessel0.67949799
91MP0003045_fibrosis0.67785756
92MP0005423_abnormal_somatic_nervous0.66391021
93MP0003252_abnormal_bile_duct0.66116309
94MP0002006_tumorigenesis0.64013607
95MP0000015_abnormal_ear_pigmentation0.63713234
96MP0000465_gastrointestinal_hemorrhage0.63116665
97MP0005535_abnormal_body_temperature0.62053131
98MP0005666_abnormal_adipose_tissue0.61880051
99MP0005376_homeostasis/metabolism_phenot0.61188130
100MP0005379_endocrine/exocrine_gland_phen0.60372938

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.81639181
2Absent/shortened dynein arms (HP:0200106)4.77444956
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.77444956
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.69549949
5Attenuation of retinal blood vessels (HP:0007843)4.54597289
6Retrobulbar optic neuritis (HP:0100654)4.25785495
7Optic neuritis (HP:0100653)4.25785495
8Myositis (HP:0100614)4.22579322
9Orchitis (HP:0100796)4.14744383
10Tubulointerstitial nephritis (HP:0001970)4.12663943
11Recurrent abscess formation (HP:0002722)4.11388932
12Chronic hepatic failure (HP:0100626)4.05048960
13Recurrent bacterial skin infections (HP:0005406)3.98901020
14Nasal polyposis (HP:0100582)3.83398180
15Gastrointestinal infarctions (HP:0005244)3.77978379
16Hypochromic microcytic anemia (HP:0004840)3.66458484
17Asymmetric septal hypertrophy (HP:0001670)3.60564434
18Elevated erythrocyte sedimentation rate (HP:0003565)3.58739040
19Gingivitis (HP:0000230)3.44689902
20Eczematoid dermatitis (HP:0000976)3.42163616
21Abnormal ciliary motility (HP:0012262)3.41970664
22Resting tremor (HP:0002322)3.41837288
23Stomatitis (HP:0010280)3.39424185
24Abnormality of macrophages (HP:0004311)3.28962000
25Progressive cerebellar ataxia (HP:0002073)3.28218301
26Abnormal rod and cone electroretinograms (HP:0008323)3.27939240
27Abnormal respiratory epithelium morphology (HP:0012253)3.27746115
28Abnormal respiratory motile cilium morphology (HP:0005938)3.27746115
29Bony spicule pigmentary retinopathy (HP:0007737)3.23955222
30Abnormal respiratory motile cilium physiology (HP:0012261)3.13662162
31Peritonitis (HP:0002586)3.12997751
32Chronic obstructive pulmonary disease (HP:0006510)3.04791943
33Obstructive lung disease (HP:0006536)3.04791943
34Abnormality of the nasal mucosa (HP:0000433)3.01819688
35Cone-rod dystrophy (HP:0000548)3.00033650
36Recurrent gram-negative bacterial infections (HP:0005420)2.94637777
37Keratoconjunctivitis sicca (HP:0001097)2.92637525
38Amelogenesis imperfecta (HP:0000705)2.91874940
39Hyperkalemia (HP:0002153)2.89164472
40Infertility (HP:0000789)2.84335162
41Postural instability (HP:0002172)2.75614904
42Abnormality of macular pigmentation (HP:0008002)2.72773199
43Male infertility (HP:0003251)2.70876488
44Recurrent skin infections (HP:0001581)2.70779943
45Keratoconjunctivitis (HP:0001096)2.69257660
46Hypoplasia of the thymus (HP:0000778)2.66271244
47Tetany (HP:0001281)2.65980484
48Hypochromic anemia (HP:0001931)2.64936642
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63941071
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.63121993
51Chest pain (HP:0100749)2.60713340
52Encephalitis (HP:0002383)2.60673722
53Recurrent fungal infections (HP:0002841)2.59949520
54Meningitis (HP:0001287)2.52409603
55Gingival bleeding (HP:0000225)2.50974263
56Menstrual irregularities (HP:0000858)2.50433815
57Inflammation of the large intestine (HP:0002037)2.44804340
58Recurrent pneumonia (HP:0006532)2.43943132
59Aplasia/Hypoplasia of the earlobes (HP:0009906)2.41747223
60Chronic mucocutaneous candidiasis (HP:0002728)2.41557529
61Recurrent cutaneous fungal infections (HP:0011370)2.41557529
62Facial shape deformation (HP:0011334)2.41408011
63Potter facies (HP:0002009)2.41408011
64Episodic fever (HP:0001954)2.40193105
65Impulsivity (HP:0100710)2.40083235
66Hemoptysis (HP:0002105)2.38943176
67Vasculitis (HP:0002633)2.36960028
68Portal hypertension (HP:0001409)2.33755541
69T lymphocytopenia (HP:0005403)2.32680493
70Arterial thrombosis (HP:0004420)2.31846181
71Osteomalacia (HP:0002749)2.30871550
72Prolonged bleeding time (HP:0003010)2.28091741
73Truncal obesity (HP:0001956)2.27160092
74Abnormality of dental color (HP:0011073)2.27002109
75Leukocytosis (HP:0001974)2.25834409
76Abnormality of T cell number (HP:0011839)2.20947259
77Increased IgE level (HP:0003212)2.20709454
78Gastrointestinal inflammation (HP:0004386)2.19429928
79Genetic anticipation (HP:0003743)2.19195249
80Acute hepatic failure (HP:0006554)2.18128026
81Abnormality of T cells (HP:0002843)2.13625671
82Abnormality of the hepatic vasculature (HP:0006707)2.10918032
83Spontaneous hematomas (HP:0007420)2.10104439
84Abnormal spermatogenesis (HP:0008669)2.07659333
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04674604
86Abnormality of T cell physiology (HP:0011840)2.03185726
87Pulmonary infiltrates (HP:0002113)1.95897682
88Urticaria (HP:0001025)1.95739097
89Macular degeneration (HP:0000608)1.94416090
90Microcytic anemia (HP:0001935)1.94049753
91Colitis (HP:0002583)1.93853964
92Glomerulopathy (HP:0100820)1.93113556
93Generalized aminoaciduria (HP:0002909)1.92102189
94Progressive sensorineural hearing impairment (HP:0000408)1.91977789
95Decreased central vision (HP:0007663)1.89490251
96Mediastinal lymphadenopathy (HP:0100721)1.87697099
97Slow saccadic eye movements (HP:0000514)1.87658954
98Abnormality of the costochondral junction (HP:0000919)1.87577364
99Spastic paraparesis (HP:0002313)1.87513582
100Abnormal urine output (HP:0012590)1.87504911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.57479446
2RIPK43.92574336
3TESK13.01010050
4STK382.89537534
5MAP4K12.73281867
6PIK3CG2.53697635
7IRAK42.32707033
8BRD42.31555523
9INSRR2.24493400
10BLK2.14858894
11PDK12.07419298
12PLK22.02083841
13MAP3K111.88302161
14STK38L1.85192616
15PDPK11.84950152
16TNK21.78778342
17CSK1.77893610
18GRK61.73583639
19CAMK1G1.72217703
20PTK2B1.63354010
21TYK21.55641189
22MAP2K31.52727488
23KSR21.46630175
24DDR21.46370205
25TAOK31.45373577
26TXK1.43012760
27PRKD31.35724487
28SYK1.33539150
29SIK21.32323690
30WNK11.32183655
31JAK31.28647598
32DYRK1B1.23900063
33BTK1.21971700
34HCK1.21647535
35MAP3K11.19859306
36FES1.19262617
37NEK61.18520013
38MAP3K21.15561560
39CSF1R1.14286761
40ZAP701.13104239
41MAP4K21.12111699
42PNCK1.01084279
43JAK20.99504295
44KIT0.98252617
45MAPK150.98141138
46EPHB10.98054632
47TESK20.96700048
48CAMK1D0.92609911
49CDK120.91716337
50IKBKE0.90284550
51FRK0.89456402
52TAOK10.88402834
53WNK30.87807191
54IKBKB0.87495959
55LYN0.87101197
56MAP3K30.80160595
57MARK30.79238227
58MARK20.70460513
59ERN10.69675949
60BCKDK0.67905496
61MAP2K20.66278384
62PRKCZ0.62603636
63FGR0.62216547
64TEC0.62071463
65RPS6KA10.60306348
66PRKAA20.59835965
67STK110.59054758
68IRAK10.57449690
69LCK0.57175584
70ACVR1B0.56075617
71PRKCQ0.55072051
72BMPR20.53821008
73ADRBK10.53378804
74CAMK10.51163190
75MAP2K40.50821455
76OXSR10.50456804
77PRKG20.49937632
78MAP3K140.49725901
79SGK20.48653469
80YES10.48602122
81CDK190.48027668
82SGK30.47470363
83RPS6KA60.47133818
84PRKG10.46882311
85TBK10.46360428
86RPS6KA20.46003004
87CDK70.45974443
88ITK0.44927146
89RPS6KL10.43019697
90RPS6KC10.43019697
91SGK4940.42828701
92SGK2230.42828701
93MATK0.42762696
94FYN0.41157465
95BMPR1B0.40188501
96JAK10.39815587
97CAMK40.36693101
98MAP3K120.36529393
99MAP3K130.36044634
100MAP3K50.33537677

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.33917815
2Leishmaniasis_Homo sapiens_hsa051402.40881405
3Osteoclast differentiation_Homo sapiens_hsa043802.25891104
4Olfactory transduction_Homo sapiens_hsa047402.24176386
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09095985
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.95212533
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93702040
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.92911196
9B cell receptor signaling pathway_Homo sapiens_hsa046621.90674890
10Staphylococcus aureus infection_Homo sapiens_hsa051501.88935269
11Dorso-ventral axis formation_Homo sapiens_hsa043201.87421715
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86454071
13Phototransduction_Homo sapiens_hsa047441.84366268
14Tuberculosis_Homo sapiens_hsa051521.77536456
15Malaria_Homo sapiens_hsa051441.68472367
16Graft-versus-host disease_Homo sapiens_hsa053321.67673821
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.67187136
18Allograft rejection_Homo sapiens_hsa053301.63689394
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62635844
20Autoimmune thyroid disease_Homo sapiens_hsa053201.60369307
21Legionellosis_Homo sapiens_hsa051341.57236771
22Chemokine signaling pathway_Homo sapiens_hsa040621.52266295
23Antigen processing and presentation_Homo sapiens_hsa046121.52065544
24Influenza A_Homo sapiens_hsa051641.46749635
25Measles_Homo sapiens_hsa051621.44583997
26Acute myeloid leukemia_Homo sapiens_hsa052211.37655480
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.36744282
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.35731143
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32655366
30T cell receptor signaling pathway_Homo sapiens_hsa046601.31776427
31Type I diabetes mellitus_Homo sapiens_hsa049401.28032027
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26491670
33Primary immunodeficiency_Homo sapiens_hsa053401.24637209
34Hematopoietic cell lineage_Homo sapiens_hsa046401.23217341
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.19151382
36Toxoplasmosis_Homo sapiens_hsa051451.14058283
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12939794
38Endocytosis_Homo sapiens_hsa041441.07187167
39Type II diabetes mellitus_Homo sapiens_hsa049301.01539661
40Herpes simplex infection_Homo sapiens_hsa051681.01213420
41African trypanosomiasis_Homo sapiens_hsa051431.00292178
42Viral myocarditis_Homo sapiens_hsa054160.99637090
43Non-small cell lung cancer_Homo sapiens_hsa052230.99330709
44Inositol phosphate metabolism_Homo sapiens_hsa005620.96261683
45Phagosome_Homo sapiens_hsa041450.94945233
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93917495
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93497140
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92056108
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91260181
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91231489
51Morphine addiction_Homo sapiens_hsa050320.91115651
52Platelet activation_Homo sapiens_hsa046110.89207943
53VEGF signaling pathway_Homo sapiens_hsa043700.88020351
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85061314
55Nitrogen metabolism_Homo sapiens_hsa009100.84365597
56Hepatitis B_Homo sapiens_hsa051610.80130726
57TNF signaling pathway_Homo sapiens_hsa046680.80048124
58FoxO signaling pathway_Homo sapiens_hsa040680.74625403
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74494136
60MAPK signaling pathway_Homo sapiens_hsa040100.72693831
61Prolactin signaling pathway_Homo sapiens_hsa049170.70683030
62Taste transduction_Homo sapiens_hsa047420.70425236
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.69831219
64Regulation of autophagy_Homo sapiens_hsa041400.68524498
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65130281
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.64817346
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64012042
68cAMP signaling pathway_Homo sapiens_hsa040240.62951290
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62407500
70Choline metabolism in cancer_Homo sapiens_hsa052310.61559570
71Fatty acid degradation_Homo sapiens_hsa000710.57740902
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57361070
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.55983093
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55674419
75Calcium signaling pathway_Homo sapiens_hsa040200.54116276
76Circadian entrainment_Homo sapiens_hsa047130.53962171
77Cholinergic synapse_Homo sapiens_hsa047250.52523045
78ABC transporters_Homo sapiens_hsa020100.51800367
79Synaptic vesicle cycle_Homo sapiens_hsa047210.51518175
80Renal cell carcinoma_Homo sapiens_hsa052110.50806763
81Long-term potentiation_Homo sapiens_hsa047200.49283098
82Renin-angiotensin system_Homo sapiens_hsa046140.48792943
83PPAR signaling pathway_Homo sapiens_hsa033200.47862766
84Fatty acid metabolism_Homo sapiens_hsa012120.47639207
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45744853
86Pertussis_Homo sapiens_hsa051330.45294255
87Viral carcinogenesis_Homo sapiens_hsa052030.44766072
88Serotonergic synapse_Homo sapiens_hsa047260.44194587
89Gastric acid secretion_Homo sapiens_hsa049710.43608304
90Shigellosis_Homo sapiens_hsa051310.42862547
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41499736
92Epstein-Barr virus infection_Homo sapiens_hsa051690.40908780
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.40464149
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39219381
95Glycerolipid metabolism_Homo sapiens_hsa005610.39040214
96Estrogen signaling pathway_Homo sapiens_hsa049150.38799350
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37733836
98mTOR signaling pathway_Homo sapiens_hsa041500.37692889
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37348849
100Salivary secretion_Homo sapiens_hsa049700.37127581

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