TSPAN17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)5.07473992
2neuronal action potential propagation (GO:0019227)5.02000697
3protein localization to endosome (GO:0036010)4.93735253
4COPI coating of Golgi vesicle (GO:0048205)4.89790371
5Golgi transport vesicle coating (GO:0048200)4.89790371
6detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.87488793
7detection of temperature stimulus involved in sensory perception (GO:0050961)4.87488793
8detection of temperature stimulus (GO:0016048)4.60910588
9cell migration in hindbrain (GO:0021535)4.47492228
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23375561
11positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.18160916
12positive regulation of synaptic transmission, GABAergic (GO:0032230)4.13765760
13negative regulation of calcium ion transport into cytosol (GO:0010523)4.12062403
14negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.09269113
15synaptic vesicle maturation (GO:0016188)4.08390372
16negative regulation of microtubule polymerization (GO:0031115)4.05343594
17synaptic vesicle exocytosis (GO:0016079)3.99946726
18negative regulation of dendrite morphogenesis (GO:0050774)3.91659623
19protein retention in ER lumen (GO:0006621)3.90363357
20barbed-end actin filament capping (GO:0051016)3.85594390
21adherens junction assembly (GO:0034333)3.81280689
22negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.78079490
23negative regulation of erythrocyte differentiation (GO:0045647)3.77264604
24negative regulation of heart rate (GO:0010459)3.76993453
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.76560018
26negative regulation of cell size (GO:0045792)3.75002073
27cell-substrate junction assembly (GO:0007044)3.73602966
28hemidesmosome assembly (GO:0031581)3.73159704
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71193153
30glutamate secretion (GO:0014047)3.71018812
31regulation of synaptic vesicle exocytosis (GO:2000300)3.66541033
32focal adhesion assembly (GO:0048041)3.65786373
33cell-substrate adherens junction assembly (GO:0007045)3.65786373
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.64228861
35proline transport (GO:0015824)3.61471391
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56818954
373-UTR-mediated mRNA stabilization (GO:0070935)3.46836014
38neuronal action potential (GO:0019228)3.46682953
39protoporphyrinogen IX metabolic process (GO:0046501)3.44660406
40membrane depolarization during action potential (GO:0086010)3.41906824
41dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.41168676
42axon cargo transport (GO:0008088)3.38395406
43cellular protein complex localization (GO:0034629)3.35757392
44pentose-phosphate shunt (GO:0006098)3.35162693
45proline biosynthetic process (GO:0006561)3.34329126
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.34084686
47epithelial cell-cell adhesion (GO:0090136)3.32554038
48regulation of glucocorticoid secretion (GO:2000849)3.30917326
49response to pain (GO:0048265)3.29573301
50calcium-mediated signaling using intracellular calcium source (GO:0035584)3.28909527
51activation of protein kinase A activity (GO:0034199)3.28566490
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.27297214
53negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.26949975
54maternal placenta development (GO:0001893)3.22714653
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.21636536
56regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.20947207
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16566702
58neuromuscular process controlling posture (GO:0050884)3.16142902
59hypotonic response (GO:0006971)3.15107189
60regulation of amyloid precursor protein catabolic process (GO:1902991)3.13174681
61regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13155225
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.12153612
63regulation of synaptic vesicle transport (GO:1902803)3.10076953
64plasma membrane repair (GO:0001778)3.09546112
65neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.07992271
66peripheral nervous system neuron development (GO:0048935)3.07441346
67stress fiber assembly (GO:0043149)3.07337201
68pinocytosis (GO:0006907)3.06030646
69modulation by symbiont of host cellular process (GO:0044068)3.05398315
70skin morphogenesis (GO:0043589)3.00429625
71negative regulation of cation channel activity (GO:2001258)2.99519344
72neuromuscular synaptic transmission (GO:0007274)2.98494918
73innervation (GO:0060384)2.97624580
74sodium ion export (GO:0071436)2.97592908
75semaphorin-plexin signaling pathway (GO:0071526)2.94937434
76protein complex localization (GO:0031503)2.94781733
77establishment of mitochondrion localization (GO:0051654)2.94513997
78glucose 6-phosphate metabolic process (GO:0051156)2.92792811
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.92765084
80positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92611740
81glucose catabolic process (GO:0006007)2.91857360
82cell communication by electrical coupling (GO:0010644)2.90513417
83protoporphyrinogen IX biosynthetic process (GO:0006782)2.90342328
84cellular potassium ion homeostasis (GO:0030007)2.90320953
85NADPH regeneration (GO:0006740)2.89608878
86protein localization to synapse (GO:0035418)2.86533714
87epithelial cell differentiation involved in prostate gland development (GO:0060742)2.86257233
88desmosome organization (GO:0002934)2.85766302
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.84211417
90neurotransmitter secretion (GO:0007269)2.83320069
91positive regulation of nuclease activity (GO:0032075)2.82246858
92positive regulation of action potential (GO:0045760)2.82041711
93basement membrane organization (GO:0071711)2.81971925
94regulation of corticosteroid hormone secretion (GO:2000846)2.81796070
95cell communication involved in cardiac conduction (GO:0086065)2.79423354
96apoptotic process involved in morphogenesis (GO:0060561)2.76567558
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.76546447
98positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.75909428
99endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.75606902
100activation of Rac GTPase activity (GO:0032863)2.75556914
101positive regulation of potassium ion transport (GO:0043268)2.75192477
102modulation by virus of host morphology or physiology (GO:0019048)2.75089221
103regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74495799
104regulation of vesicle fusion (GO:0031338)2.74463291
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.74388174
106organelle transport along microtubule (GO:0072384)2.73995932
107RNA stabilization (GO:0043489)2.72091565
108mRNA stabilization (GO:0048255)2.72091565
109mating behavior (GO:0007617)2.72080835
110locomotory exploration behavior (GO:0035641)2.71714928
111modulation by virus of host process (GO:0019054)2.71578201
112neuron cell-cell adhesion (GO:0007158)2.71191087
113regulation of protein kinase A signaling (GO:0010738)2.69316925
114layer formation in cerebral cortex (GO:0021819)2.68385247
115response to acidic pH (GO:0010447)2.68038894
116enteric nervous system development (GO:0048484)2.67598332
117positive regulation of receptor recycling (GO:0001921)2.66519957
118activation of MAPKKK activity (GO:0000185)2.65791787
119protein targeting to plasma membrane (GO:0072661)2.65724525
120positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65660300
121endoplasmic reticulum unfolded protein response (GO:0030968)2.65451971
122positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65355934
123cell adhesion mediated by integrin (GO:0033627)2.64265124
124endothelial cell chemotaxis (GO:0035767)2.63966910
125positive regulation of steroid hormone secretion (GO:2000833)2.62879678
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.62793368
127endocytic recycling (GO:0032456)2.62678118
128negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.62180127
129tachykinin receptor signaling pathway (GO:0007217)2.62056259
130ER-nucleus signaling pathway (GO:0006984)2.61918776
131regulation of cholesterol biosynthetic process (GO:0045540)2.61363960
132cerebellar Purkinje cell differentiation (GO:0021702)2.60823491
133regulation of extracellular matrix disassembly (GO:0010715)2.59020012
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.58620753
135pyrimidine-containing compound salvage (GO:0008655)2.57992519
136pyrimidine nucleoside salvage (GO:0043097)2.57992519
137energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.57984864
138ATP hydrolysis coupled proton transport (GO:0015991)2.57984864
139positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.57736119
140regulation of synapse structural plasticity (GO:0051823)2.57718751
141sequestering of actin monomers (GO:0042989)2.57656321
142embryonic process involved in female pregnancy (GO:0060136)2.57498592
143vesicle transport along microtubule (GO:0047496)2.57460591
144response to water (GO:0009415)2.56194546
145mannose metabolic process (GO:0006013)2.56109413
146regulation of early endosome to late endosome transport (GO:2000641)2.55055250
147cellular response to ATP (GO:0071318)2.54442973
148chemosensory behavior (GO:0007635)2.52750381
149negative regulation of calcium ion transmembrane transport (GO:1903170)2.52367408
150negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52367408
151negative regulation of dendrite development (GO:2000171)2.52234118
152regulation of nuclease activity (GO:0032069)2.51690112
153sensory perception of pain (GO:0019233)2.51375084
154retinal ganglion cell axon guidance (GO:0031290)2.50966643
155establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50178648
156mitochondrion transport along microtubule (GO:0047497)2.50178648
157intracellular estrogen receptor signaling pathway (GO:0030520)2.48973682
158protein maturation by protein folding (GO:0022417)2.48793807
159regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48673992
160vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48002526
161diaphragm development (GO:0060539)2.47584902
162exploration behavior (GO:0035640)2.47259867
163regulation of neuronal synaptic plasticity (GO:0048168)2.47181410
164apoptotic cell clearance (GO:0043277)2.46495393
165negative regulation of fatty acid transport (GO:2000192)2.46450087
166endodermal cell differentiation (GO:0035987)2.46271516
167neuromuscular process controlling balance (GO:0050885)2.45524787
168behavioral response to pain (GO:0048266)2.45248935
169protein localization to microtubule (GO:0035372)2.44034529
170cellular response to unfolded protein (GO:0034620)2.42826722
171vocalization behavior (GO:0071625)2.42649112
172urea cycle (GO:0000050)2.41779306
173regulation of translational fidelity (GO:0006450)2.41587758
174regulation of cAMP-dependent protein kinase activity (GO:2000479)2.41440527
175regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41412388
176regulation of calcium ion transmembrane transporter activity (GO:1901019)2.41380636
177regulation of calcium ion transmembrane transport (GO:1903169)2.41380636
178regulation of cell communication by electrical coupling (GO:0010649)2.40801495
179regulation of synaptic transmission, GABAergic (GO:0032228)2.40754478
180synaptic vesicle endocytosis (GO:0048488)2.40551021
181positive regulation of axon extension (GO:0045773)2.39828147
182cellular response to virus (GO:0098586)2.39776506
183actin filament bundle organization (GO:0061572)2.39558629
184actin filament bundle assembly (GO:0051017)2.39558629
185membrane protein ectodomain proteolysis (GO:0006509)2.38767541
186regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36934178
187response to laminar fluid shear stress (GO:0034616)2.36116953
188nucleobase-containing small molecule interconversion (GO:0015949)2.35607074
189retrograde transport, endosome to Golgi (GO:0042147)2.35557737
190hyaluronan catabolic process (GO:0030214)2.35148709
191branching involved in mammary gland duct morphogenesis (GO:0060444)2.34323830
192adenine nucleotide transport (GO:0051503)2.33942976
193negative regulation of focal adhesion assembly (GO:0051895)2.32786299
194negative regulation of cell junction assembly (GO:1901889)2.32786299
195negative regulation of adherens junction organization (GO:1903392)2.32786299
196vesicle coating (GO:0006901)2.32470554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97068786
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.78377704
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89327631
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81144413
5JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74706405
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.69143586
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66493553
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66493553
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65389844
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61140531
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58879184
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57000474
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45211293
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41512020
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37359703
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34997297
17ZNF263_19887448_ChIP-Seq_K562_Human2.32932818
18RACK7_27058665_Chip-Seq_MCF-7_Human2.31648676
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30976064
20VDR_21846776_ChIP-Seq_THP-1_Human2.25984262
21MYC_22102868_ChIP-Seq_BL_Human2.22690594
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.17867276
23REST_21632747_ChIP-Seq_MESCs_Mouse2.16902234
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13206869
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.11196920
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10063186
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.06786438
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03051405
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98916169
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.97545487
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97472216
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95472940
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89023602
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87841509
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.87573928
36TCF7_22412390_ChIP-Seq_EML_Mouse1.86564228
37GBX2_23144817_ChIP-Seq_PC3_Human1.84950641
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.84276738
39KDM2B_26808549_Chip-Seq_DND41_Human1.83585354
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82991885
41CLOCK_20551151_ChIP-Seq_293T_Human1.81028201
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.77783328
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.74951646
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.73910159
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69980416
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.66206461
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65361121
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64380267
49DROSHA_22980978_ChIP-Seq_HELA_Human1.64009741
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63031380
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62629457
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61573773
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59053398
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54175101
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52855370
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.52654351
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52100546
58KDM2B_26808549_Chip-Seq_K562_Human1.51971872
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.51836333
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49625717
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48184060
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43714758
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.43598715
64ATF3_27146783_Chip-Seq_COLON_Human1.43236313
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43206488
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.43050091
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42884517
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41096643
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38700365
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37326798
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37088183
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35616321
73ZNF274_21170338_ChIP-Seq_K562_Hela1.33388007
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.32128874
75E2F7_22180533_ChIP-Seq_HELA_Human1.29972041
76AR_21572438_ChIP-Seq_LNCaP_Human1.29755548
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29377486
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.28434068
79P68_20966046_ChIP-Seq_HELA_Human1.28428824
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28120352
81CTCF_27219007_Chip-Seq_Bcells_Human1.27761115
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26311377
83NCOR1_26117541_ChIP-Seq_K562_Human1.25768577
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25697872
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25522562
86SMC4_20622854_ChIP-Seq_HELA_Human1.24311861
87* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23784114
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23561581
89MAF_26560356_Chip-Seq_TH1_Human1.23525743
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23513082
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22307512
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22223995
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22072757
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21982125
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21040726
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19988781
97* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19819275
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19758169
99TP53_22127205_ChIP-Seq_IMR90_Human1.19555249
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19225102
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.19153474
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18257535
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18059922
104CREB1_26743006_Chip-Seq_LNCaP_Human1.18051299
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18010478
106VDR_24763502_ChIP-Seq_THP-1_Human1.17769503
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16976045
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16185908
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15868067
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.14565635
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13040345
112AHR_22903824_ChIP-Seq_MCF-7_Human1.11491215
113GATA1_19941826_ChIP-Seq_K562_Human1.11111484
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10385894
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08942460
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08251256
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07319193
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.07116860
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.06940955
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06408918
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06302437
122SMAD4_21799915_ChIP-Seq_A2780_Human1.06206624
123LXR_22292898_ChIP-Seq_THP-1_Human1.05873784
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.04778078
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04419620
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.04232945
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03048252
128WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03037089
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02726908
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02608368
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01916924
132EP300_21415370_ChIP-Seq_HL-1_Mouse1.01872861
133ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01261650
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01042012
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00714566
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00355142
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.99910333
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99334572
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98368550
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98338552
141MAF_26560356_Chip-Seq_TH2_Human0.97670772
142NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97457517
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.97369002
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97059930
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96111964
146UTX_26944678_Chip-Seq_JUKART_Human0.95533637
147SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95028068
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94972509
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94652356
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93919171
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93825102
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.93176730
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92165605
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91803985
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.91721818
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.90731513
157KLF4_19829295_ChIP-Seq_ESCs_Human0.90258865
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.90148206
159* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88004675
160TAF15_26573619_Chip-Seq_HEK293_Human0.87647594
161CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86601205
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.85027347
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84440191
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83514801
165P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82910106
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81876291
167SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80233352
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.80105643
169SA1_27219007_Chip-Seq_ERYTHROID_Human0.80023250
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79447206
171OCT4_19829295_ChIP-Seq_ESCs_Human0.78518802
172CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77656052
173NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76399131
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76399131
175EOMES_21245162_ChIP-Seq_HESCs_Human0.76355686
176AR_19668381_ChIP-Seq_PC3_Human0.76289973
177P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76088134
178* AR_25329375_ChIP-Seq_VCAP_Human0.73197876
179PIAS1_25552417_ChIP-Seq_VCAP_Human0.73060202
180ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.72920009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.25904203
2MP0002735_abnormal_chemical_nociception5.17986477
3MP0001968_abnormal_touch/_nociception4.45885561
4MP0004270_analgesia4.14094445
5MP0004858_abnormal_nervous_system3.93673610
6MP0004859_abnormal_synaptic_plasticity3.55351953
7MP0002734_abnormal_mechanical_nocicepti3.43606942
8MP0002736_abnormal_nociception_after3.42009453
9MP0002733_abnormal_thermal_nociception3.36924253
10MP0003566_abnormal_cell_adhesion3.15403686
11MP0005451_abnormal_body_composition3.14091750
12MP0006276_abnormal_autonomic_nervous3.09220148
13MP0001970_abnormal_pain_threshold3.02598969
14MP0001986_abnormal_taste_sensitivity2.99662334
15MP0005058_abnormal_lysosome_morphology2.77563997
16MP0010386_abnormal_urinary_bladder2.65163119
17MP0010234_abnormal_vibrissa_follicle2.60164513
18MP0001849_ear_inflammation2.57702888
19MP0003635_abnormal_synaptic_transmissio2.50794101
20MP0002877_abnormal_melanocyte_morpholog2.50248568
21MP0002272_abnormal_nervous_system2.38260724
22MP0003329_amyloid_beta_deposits2.32805009
23MP0009840_abnormal_foam_cell2.25947517
24MP0005076_abnormal_cell_differentiation2.25417076
25MP0003191_abnormal_cellular_cholesterol2.25310485
26MP0009046_muscle_twitch2.19438721
27MP0003880_abnormal_central_pattern2.16617271
28MP0002184_abnormal_innervation2.11728903
29MP0000751_myopathy2.11676322
30MP0005257_abnormal_intraocular_pressure2.08313835
31MP0002064_seizures2.01097018
32MP0004185_abnormal_adipocyte_glucose1.98562718
33MP0003453_abnormal_keratinocyte_physiol1.88035846
34MP0002796_impaired_skin_barrier1.87176280
35MP0002067_abnormal_sensory_capabilities1.84879192
36MP0009745_abnormal_behavioral_response1.84210245
37MP0001440_abnormal_grooming_behavior1.81331146
38MP0002063_abnormal_learning/memory/cond1.80931256
39MP0004145_abnormal_muscle_electrophysio1.76800389
40MP0003091_abnormal_cell_migration1.76054914
41MP0000537_abnormal_urethra_morphology1.74409385
42MP0002572_abnormal_emotion/affect_behav1.73235538
43MP0005409_darkened_coat_color1.70672968
44MP0000858_altered_metastatic_potential1.69158273
45MP0002060_abnormal_skin_morphology1.65450830
46MP0003279_aneurysm1.65007758
47MP0000955_abnormal_spinal_cord1.63602968
48MP0003300_gastrointestinal_ulcer1.55461703
49MP0005501_abnormal_skin_physiology1.53873042
50MP0000733_abnormal_muscle_development1.53846978
51MP0003656_abnormal_erythrocyte_physiolo1.53381223
52MP0004811_abnormal_neuron_physiology1.52072545
53MP0009053_abnormal_anal_canal1.50578766
54MP0002751_abnormal_autonomic_nervous1.48401569
55MP0005423_abnormal_somatic_nervous1.47359160
56MP0000749_muscle_degeneration1.47017380
57MP0002909_abnormal_adrenal_gland1.45159413
58MP0000013_abnormal_adipose_tissue1.42886240
59MP0010352_gastrointestinal_tract_polyps1.42063371
60MP0000467_abnormal_esophagus_morphology1.40977480
61MP0002837_dystrophic_cardiac_calcinosis1.39098960
62MP0000920_abnormal_myelination1.35894903
63MP0008569_lethality_at_weaning1.34992520
64MP0003634_abnormal_glial_cell1.33815029
65MP0001348_abnormal_lacrimal_gland1.33632923
66MP0002882_abnormal_neuron_morphology1.30986307
67MP0000747_muscle_weakness1.29737568
68MP0004947_skin_inflammation1.29451622
69MP0001958_emphysema1.26224453
70MP0009278_abnormal_bone_marrow1.25813117
71MP0004142_abnormal_muscle_tone1.25400866
72MP0001501_abnormal_sleep_pattern1.24790539
73MP0010368_abnormal_lymphatic_system1.24722522
74MP0008438_abnormal_cutaneous_collagen1.23640034
75MP0005023_abnormal_wound_healing1.22472952
76MP0000678_abnormal_parathyroid_gland1.22265610
77MP0000767_abnormal_smooth_muscle1.22263072
78MP0004510_myositis1.22055779
79MP0005623_abnormal_meninges_morphology1.22054509
80MP0000604_amyloidosis1.20726153
81MP0001486_abnormal_startle_reflex1.20156616
82MP0000778_abnormal_nervous_system1.18401202
83MP0005386_behavior/neurological_phenoty1.17334241
84MP0004924_abnormal_behavior1.17334241
85MP0010030_abnormal_orbit_morphology1.16760656
86MP0003941_abnormal_skin_development1.15748814
87MP0003172_abnormal_lysosome_physiology1.14127809
88MP0002066_abnormal_motor_capabilities/c1.13777362
89MP0003303_peritoneal_inflammation1.12782474
90MP0000490_abnormal_crypts_of1.12011944
91MP0001299_abnormal_eye_distance/1.11934611
92MP0000566_synostosis1.11606840
93MP0002229_neurodegeneration1.11181365
94MP0003633_abnormal_nervous_system1.09707578
95MP0002896_abnormal_bone_mineralization1.06840287
96MP0009780_abnormal_chondrocyte_physiolo1.06421176
97MP0003183_abnormal_peptide_metabolism1.05401983
98MP0004036_abnormal_muscle_relaxation1.04244946
99MP0001216_abnormal_epidermal_layer1.03447170
100MP0000579_abnormal_nail_morphology1.03159299
101MP0005666_abnormal_adipose_tissue1.01875295
102MP0004264_abnormal_extraembryonic_tissu1.00058697
103MP0003045_fibrosis0.99741779
104MP0003879_abnormal_hair_cell0.99384074
105MP0002557_abnormal_social/conspecific_i0.97515426
106MP0003436_decreased_susceptibility_to0.96815500
107MP0001905_abnormal_dopamine_level0.96062608
108MP0009672_abnormal_birth_weight0.94560867
109MP0005621_abnormal_cell_physiology0.93788227
110MP0005375_adipose_tissue_phenotype0.93581719
111MP0003631_nervous_system_phenotype0.92760549
112MP0002752_abnormal_somatic_nervous0.91844149
113MP0000759_abnormal_skeletal_muscle0.89995136
114MP0009931_abnormal_skin_appearance0.89907183
115MP0008775_abnormal_heart_ventricle0.89023372
116MP0001915_intracranial_hemorrhage0.88694128
117MP0001730_embryonic_growth_arrest0.87804454
118MP0002089_abnormal_postnatal_growth/wei0.87691001
119MP0004742_abnormal_vestibular_system0.87425904
120MP0005410_abnormal_fertilization0.87037372
121MP0003075_altered_response_to0.86842176
122MP0002998_abnormal_bone_remodeling0.85287057
123MP0003448_altered_tumor_morphology0.84902687
124MP0009384_cardiac_valve_regurgitation0.84854530
125MP0006138_congestive_heart_failure0.84736740
126MP0001270_distended_abdomen0.84729471
127MP0008260_abnormal_autophagy0.84621026
128MP0002254_reproductive_system_inflammat0.84206790
129MP0004087_abnormal_muscle_fiber0.83777405
130MP0010307_abnormal_tumor_latency0.82681393
131MP0005083_abnormal_biliary_tract0.81876253
132MP0000762_abnormal_tongue_morphology0.81681413
133MP0004130_abnormal_muscle_cell0.81416216
134MP0000538_abnormal_urinary_bladder0.81370199
135MP0001243_abnormal_dermal_layer0.80796863
136MP0001873_stomach_inflammation0.79545867
137MP0005275_abnormal_skin_tensile0.78268557
138MP0003828_pulmonary_edema0.77896095
139MP0003122_maternal_imprinting0.77283160
140MP0002080_prenatal_lethality0.76902585
141MP0010630_abnormal_cardiac_muscle0.76281799
142MP0002269_muscular_atrophy0.75350661
143MP0002638_abnormal_pupillary_reflex0.75308235
144MP0004808_abnormal_hematopoietic_stem0.73416792
145MP0002086_abnormal_extraembryonic_tissu0.73028285
146MP0004272_abnormal_basement_membrane0.72961524
147MP0005508_abnormal_skeleton_morphology0.72832513
148MP0000534_abnormal_ureter_morphology0.72099250
149MP0005645_abnormal_hypothalamus_physiol0.71098955
150MP0006082_CNS_inflammation0.70896753
151MP0000343_altered_response_to0.70199988
152MP0003632_abnormal_nervous_system0.70140965
153MP0009333_abnormal_splenocyte_physiolog0.69749319
154MP0001727_abnormal_embryo_implantation0.69396653
155MP0010771_integument_phenotype0.69342571
156MP0005535_abnormal_body_temperature0.69227824
157MP0008874_decreased_physiological_sensi0.68894860
158MP0004084_abnormal_cardiac_muscle0.68611157
159MP0001542_abnormal_bone_strength0.68545860
160MP0001533_abnormal_skeleton_physiology0.68060122
161MP0004484_altered_response_of0.66868669
162MP0000477_abnormal_intestine_morphology0.66696963
163MP0001984_abnormal_olfaction0.66310199
164MP0002972_abnormal_cardiac_muscle0.65275858
165MP0005390_skeleton_phenotype0.65045563
166MP0002098_abnormal_vibrissa_morphology0.64758786
167MP0001614_abnormal_blood_vessel0.64711334
168MP0004085_abnormal_heartbeat0.64326464
169MP0004885_abnormal_endolymph0.64206947
170MP0000350_abnormal_cell_proliferation0.64050896
171MP0002396_abnormal_hematopoietic_system0.63994569
172MP0000003_abnormal_adipose_tissue0.61103071
173MP0001502_abnormal_circadian_rhythm0.59854141
174MP0001664_abnormal_digestion0.59580324
175MP0001756_abnormal_urination0.59131516
176MP0000750_abnormal_muscle_regeneration0.58848719
177MP0003690_abnormal_glial_cell0.58286783
178MP0002090_abnormal_vision0.56940627
179MP0002332_abnormal_exercise_endurance0.56241590
180MP0002106_abnormal_muscle_physiology0.56198600
181MP0005620_abnormal_muscle_contractility0.55897017
182MP0004233_abnormal_muscle_weight0.55550617
183MP0001963_abnormal_hearing_physiology0.55155133

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.43547170
2Ulnar claw (HP:0001178)6.40742733
3Action tremor (HP:0002345)5.29994958
4Insidious onset (HP:0003587)4.73272674
5Termporal pattern (HP:0011008)4.73272674
6Pheochromocytoma (HP:0002666)4.09023476
7Supranuclear gaze palsy (HP:0000605)4.06065641
8Segmental peripheral demyelination/remyelination (HP:0003481)4.03200780
9Protrusio acetabuli (HP:0003179)3.79958690
10Neuroendocrine neoplasm (HP:0100634)3.66906381
11Hypercortisolism (HP:0001578)3.54429405
12Ankle clonus (HP:0011448)3.44591608
13Myotonia (HP:0002486)3.43716570
14Foot dorsiflexor weakness (HP:0009027)3.34773939
15Focal seizures (HP:0007359)3.34091636
16Hammertoe (HP:0001765)3.29312010
17Atonic seizures (HP:0010819)3.23482599
18Vertebral compression fractures (HP:0002953)3.19437329
19Hyperacusis (HP:0010780)3.19116006
20Focal motor seizures (HP:0011153)3.06520599
21Impaired pain sensation (HP:0007328)3.03979385
22Abnormality of pain sensation (HP:0010832)3.03979385
23Increased connective tissue (HP:0009025)3.02465592
24Visual hallucinations (HP:0002367)3.02069924
25Progressive cerebellar ataxia (HP:0002073)3.01746564
26Steppage gait (HP:0003376)2.97838898
27Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.97179008
28Abnormality of the foot musculature (HP:0001436)2.94299081
29Abnormality of the vocal cords (HP:0008777)2.90517907
30Hypoventilation (HP:0002791)2.89978181
31Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.89543670
32Onion bulb formation (HP:0003383)2.83473859
33Distal lower limb muscle weakness (HP:0009053)2.80120651
34Peripheral hypomyelination (HP:0007182)2.74242353
35Atrophic scars (HP:0001075)2.72257262
36Fragile skin (HP:0001030)2.72064625
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.70771456
38Neoplasm of the peripheral nervous system (HP:0100007)2.69693936
39Failure to thrive in infancy (HP:0001531)2.69573204
40Postural tremor (HP:0002174)2.69210590
41Distal lower limb amyotrophy (HP:0008944)2.68479467
42Insomnia (HP:0100785)2.66681114
43Abnormality of the corticospinal tract (HP:0002492)2.63472569
44Spinal rigidity (HP:0003306)2.62591217
45Long palpebral fissure (HP:0000637)2.61917088
46Hyporeflexia of lower limbs (HP:0002600)2.61806669
47Neurofibrillary tangles (HP:0002185)2.56053365
48Febrile seizures (HP:0002373)2.55240275
49Dysautonomia (HP:0002459)2.54467018
50Decreased motor nerve conduction velocity (HP:0003431)2.53123249
51Broad face (HP:0000283)2.47299894
52Rapidly progressive (HP:0003678)2.47274871
53Distal sensory impairment (HP:0002936)2.44849003
54Cerebral aneurysm (HP:0004944)2.44274930
55Distal arthrogryposis (HP:0005684)2.43414628
56Reticulocytosis (HP:0001923)2.43058422
57Absence seizures (HP:0002121)2.43000866
58Cervical subluxation (HP:0003308)2.40675408
59Urinary urgency (HP:0000012)2.35656839
60Thin bony cortex (HP:0002753)2.35296140
61Disproportionate tall stature (HP:0001519)2.35186214
62Asymmetry of the thorax (HP:0001555)2.34663370
63Depression (HP:0000716)2.32789136
64Polycythemia (HP:0001901)2.31933168
65Epileptic encephalopathy (HP:0200134)2.31069798
66Generalized tonic-clonic seizures (HP:0002069)2.29351732
67Shallow orbits (HP:0000586)2.28555054
68Ulnar bowing (HP:0003031)2.28468303
69Blue sclerae (HP:0000592)2.27535970
70Arterial tortuosity (HP:0005116)2.23215368
71Trismus (HP:0000211)2.22889967
72Amblyopia (HP:0000646)2.22535671
73Dysostosis multiplex (HP:0000943)2.22038606
74Dialeptic seizures (HP:0011146)2.21410348
75Abnormality of the distal phalanges of the toes (HP:0010182)2.21335023
76Abnormality of calcium-phosphate metabolism (HP:0100530)2.19946552
77Natal tooth (HP:0000695)2.19570771
78Flat acetabular roof (HP:0003180)2.19036294
79Cerebral inclusion bodies (HP:0100314)2.18456274
80Spastic gait (HP:0002064)2.17900603
81Mildly elevated creatine phosphokinase (HP:0008180)2.16780911
82Osteolytic defects of the hand bones (HP:0009699)2.14878537
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.14878537
84Short nail (HP:0001799)2.14005552
85Sparse lateral eyebrow (HP:0005338)2.13768618
86Ankle contracture (HP:0006466)2.12848220
87Achilles tendon contracture (HP:0001771)2.12489935
88Delusions (HP:0000746)2.11564274
89Vascular tortuosity (HP:0004948)2.10833441
90Hyperparathyroidism (HP:0000843)2.09126634
91Agitation (HP:0000713)2.08824877
92Mucopolysacchariduria (HP:0008155)2.08764156
93Urinary glycosaminoglycan excretion (HP:0003541)2.08764156
94Abnormality of skeletal muscle fiber size (HP:0012084)2.08327905
95Limb dystonia (HP:0002451)2.08193053
96Obstructive sleep apnea (HP:0002870)2.08060754
97Truncal ataxia (HP:0002078)2.07590643
98Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06206505
99Hypoplasia of the brainstem (HP:0002365)2.06206505
100Muscle stiffness (HP:0003552)2.04451289
101Increased variability in muscle fiber diameter (HP:0003557)2.03643875
102Selective tooth agenesis (HP:0001592)2.01783599
103Autoamputation (HP:0001218)2.00820879
104Increased CSF protein (HP:0002922)2.00809191
105Abnormality of polysaccharide metabolism (HP:0011012)1.99360879
106Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99360879
107Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99360879
108Type 1 muscle fiber predominance (HP:0003803)1.99017281
109Anxiety (HP:0000739)1.98832722
110Hand muscle atrophy (HP:0009130)1.97995776
111Retinal dysplasia (HP:0007973)1.97162344
112Genu recurvatum (HP:0002816)1.97152794
113Akinesia (HP:0002304)1.96693298
114Abnormal eating behavior (HP:0100738)1.96664777
115Lower limb muscle weakness (HP:0007340)1.96409538
116Mitral regurgitation (HP:0001653)1.96138243
117Myopathic facies (HP:0002058)1.95072487
118Cholelithiasis (HP:0001081)1.94768745
119Advanced eruption of teeth (HP:0006288)1.94166937
120Bradycardia (HP:0001662)1.92636547
121Bladder diverticulum (HP:0000015)1.92431312
122Diaphragmatic weakness (HP:0009113)1.91095857
123Abnormality of the lower motor neuron (HP:0002366)1.90776136
124Lower limb amyotrophy (HP:0007210)1.90270651
125Dysmetria (HP:0001310)1.90007534
126Cerebral hemorrhage (HP:0001342)1.89698905
127Wormian bones (HP:0002645)1.89039209
128Upper limb amyotrophy (HP:0009129)1.89006773
129Distal upper limb amyotrophy (HP:0007149)1.89006773
130Difficulty climbing stairs (HP:0003551)1.86439372
131Generalized amyotrophy (HP:0003700)1.86126607
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85647116
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.85647116
134Slow progression (HP:0003677)1.85188133
135Megalencephaly (HP:0001355)1.85029309
136Ventricular fibrillation (HP:0001663)1.84428097
137Abnormal autonomic nervous system physiology (HP:0012332)1.84356410
138Urinary bladder sphincter dysfunction (HP:0002839)1.83149711
139Neuronal loss in central nervous system (HP:0002529)1.83072637
140Abnormality of glycosphingolipid metabolism (HP:0004343)1.82892745
141Abnormality of glycolipid metabolism (HP:0010969)1.82892745
142Abnormality of liposaccharide metabolism (HP:0010968)1.82892745
143Difficulty running (HP:0009046)1.82687127
144Scanning speech (HP:0002168)1.80700623
145Impaired proprioception (HP:0010831)1.80632597
146Abnormality of the Achilles tendon (HP:0005109)1.80221083
147Back pain (HP:0003418)1.79871939
148Elbow flexion contracture (HP:0002987)1.78344724
149Dilatation of the ascending aorta (HP:0005111)1.77693304
150Abnormality of oral frenula (HP:0000190)1.77329174
151Ankyloglossia (HP:0010296)1.77023256
152Mutism (HP:0002300)1.76499035
153Abnormality of the thoracic spine (HP:0100711)1.76467053
154Axonal loss (HP:0003447)1.75723300
155Menstrual irregularities (HP:0000858)1.75010026
156Premature rupture of membranes (HP:0001788)1.74741340
157Abnormal gallbladder physiology (HP:0012438)1.74555685
158Cholecystitis (HP:0001082)1.74555685
159Biconcave vertebral bodies (HP:0004586)1.74507572
160Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73973006
161Torticollis (HP:0000473)1.71939318
162Polygenic inheritance (HP:0010982)1.71913916
163Congenital glaucoma (HP:0001087)1.71718568
164Growth hormone excess (HP:0000845)1.71492014
165Stridor (HP:0010307)1.70131352
166Peripheral demyelination (HP:0011096)1.69261801
167Poor suck (HP:0002033)1.68944007
168Syringomyelia (HP:0003396)1.68875790
169Spinal cord lesions (HP:0100561)1.68875790
170Adrenal overactivity (HP:0002717)1.68758097
171Clonus (HP:0002169)1.68327125
172Interstitial pulmonary disease (HP:0006530)1.67414750
173Spinal cord compression (HP:0002176)1.67220650
174Abnormality of the heme biosynthetic pathway (HP:0010472)1.65807899
175Bulbar palsy (HP:0001283)1.64796754
176J-shaped sella turcica (HP:0002680)1.64754477
177Abnormality of nail color (HP:0100643)1.63662175
178Aortic dissection (HP:0002647)1.62377121
179Neonatal death (HP:0003811)1.61090306
180Pterygium (HP:0001059)1.60349788
181Hypertensive crisis (HP:0100735)1.59721087
182Aneurysm (HP:0002617)1.59363361
183Asymmetric septal hypertrophy (HP:0001670)1.59160602
184Nonimmune hydrops fetalis (HP:0001790)1.58866541
185Mitral valve prolapse (HP:0001634)1.58771834
186Abnormal ossification of hand bones (HP:0005921)1.58511700
187Abnormal gallbladder morphology (HP:0012437)1.57529925

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK13.69476000
2MAP3K93.33173444
3KSR23.31536875
4NTRK33.24496211
5PRPF4B3.22696827
6IRAK33.17820159
7LIMK13.17121945
8MINK12.96129187
9SMG12.87770125
10LMTK22.67029215
11GRK52.66295431
12EEF2K2.64673941
13SIK12.55834246
14NME22.42460535
15TTN2.34056890
16MAP3K22.32805785
17PAK62.28993544
18LATS22.27890338
19ERN12.16011093
20EPHA22.13980576
21ARAF2.13228931
22MAP3K31.99101617
23ICK1.92434199
24MAP3K121.87445920
25RET1.80414805
26PAK41.79803329
27PHKG21.72541834
28PHKG11.72541834
29TAOK21.69672711
30TESK11.66944930
31RIPK41.66809089
32PKN21.66738077
33FER1.58812299
34MAPKAPK31.58267949
35MAP2K31.55660273
36MAP3K41.55512249
37MST1R1.49866275
38STK391.49692697
39MAP2K41.47878108
40MARK11.46993679
41MAP3K101.42989643
42FGFR41.42747506
43DAPK21.39393076
44CDK121.35222517
45WNK11.31141478
46MAP2K11.24742640
47PRKD31.24712427
48CAMKK21.22873291
49RIPK11.22431048
50STK241.21098256
51PTK61.17664523
52CDK51.17398873
53MAP3K11.17367627
54UHMK11.13515229
55PTK2B1.12425334
56TRIB31.11493777
57PAK31.11353112
58WNK41.10654650
59CDK141.10055818
60EPHB11.09485993
61MATK1.08068080
62BMX1.02721138
63CAMKK11.00791171
64MTOR0.97477614
65EPHB20.96538266
66MET0.95898180
67MAPK130.93888307
68EPHA30.93301955
69JAK30.93045789
70MAPKAPK50.92016158
71MAP3K110.91453148
72STK380.90427175
73BRAF0.89858784
74PRKD20.89508649
75MAP2K70.88513815
76PINK10.88177875
77TESK20.88131355
78MAP3K80.83795910
79CDK150.80144699
80CDK180.79895620
81RPS6KL10.79492650
82RPS6KC10.79492650
83ROCK20.78238711
84IRAK20.77588381
85LRRK20.77160798
86MAP3K60.75088391
87RPS6KA20.74864981
88TBK10.74234327
89MAP2K20.73570030
90DAPK30.71931710
91CDK11A0.71690898
92CDK190.71067172
93CAMK1D0.70233531
94PTK20.69979024
95DDR20.66987187
96CASK0.66672824
97RPS6KB20.66612405
98PRKCG0.65225997
99PLK20.65121841
100TYRO30.64484416
101SCYL20.63955725
102ADRBK10.62990675
103PRKCE0.61913944
104CAMK2G0.60907122
105ZAP700.60134018
106CAMK2A0.59348371
107PDPK10.58743478
108SGK2230.58586329
109SGK4940.58586329
110CAMK2D0.58505170
111CDC42BPA0.58452868
112IRAK40.58411180
113PIM20.57331275
114NEK10.56244227
115PDGFRA0.55354810
116MAP3K130.55207318
117PAK20.54079927
118PNCK0.53910901
119PRKG20.53229077
120CSNK1G20.52795340
121TAOK10.52169978
122EIF2AK10.51137319
123MYLK0.50723918
124RPS6KA60.50596002
125DAPK10.49707312
126NTRK20.49232047
127MOS0.48261878
128CDK70.46510127
129SIK30.46138144
130TNK20.45216449
131ABL20.45154679
132TYK20.43751898
133KSR10.43533097
134PRKCH0.43485797
135MARK20.42914672
136MAP3K140.42867634
137TRPM70.42381608
138MAPK110.42285745
139ROCK10.41567542
140ADRBK20.41347161
141GRK70.39698358
142OXSR10.39530112
143ILK0.37799177
144CSNK1G30.37510375
145AKT20.37487022
146CAMK1G0.37232625
147PDK40.36711033
148PDK30.36711033
149CAMK2B0.35960165
150PDK10.35188956
151CLK10.35181942
152ERBB40.34120698
153TGFBR20.32551779
154PRKCI0.31347542
155MAPKAPK20.30849828
156PDGFRB0.30608756
157PAK10.30220532
158CDK90.30202999
159MAPK120.30035528
160CCNB10.29360476
161GRK60.29310086
162AURKA0.27476565

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.33560201
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.21283725
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.83469124
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.72669548
5Other glycan degradation_Homo sapiens_hsa005112.43559374
6Chronic myeloid leukemia_Homo sapiens_hsa052202.10661266
7Bladder cancer_Homo sapiens_hsa052191.97842059
8Oxidative phosphorylation_Homo sapiens_hsa001901.96328190
9Collecting duct acid secretion_Homo sapiens_hsa049661.83235943
10Cardiac muscle contraction_Homo sapiens_hsa042601.80678778
11Acute myeloid leukemia_Homo sapiens_hsa052211.79362891
12Insulin secretion_Homo sapiens_hsa049111.75453680
13Pentose phosphate pathway_Homo sapiens_hsa000301.73189157
14Parkinsons disease_Homo sapiens_hsa050121.71802098
15Long-term potentiation_Homo sapiens_hsa047201.61714995
16Circadian entrainment_Homo sapiens_hsa047131.59879229
17Cholinergic synapse_Homo sapiens_hsa047251.58785022
18Pancreatic cancer_Homo sapiens_hsa052121.58404731
19Dopaminergic synapse_Homo sapiens_hsa047281.56357549
20Non-small cell lung cancer_Homo sapiens_hsa052231.55771320
21Olfactory transduction_Homo sapiens_hsa047401.54466797
22Fructose and mannose metabolism_Homo sapiens_hsa000511.54419958
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52958437
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52833225
25Alzheimers disease_Homo sapiens_hsa050101.51467802
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50955149
27Vibrio cholerae infection_Homo sapiens_hsa051101.50923065
28Nicotine addiction_Homo sapiens_hsa050331.49285674
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.47940483
30Salivary secretion_Homo sapiens_hsa049701.47733226
31Galactose metabolism_Homo sapiens_hsa000521.47537102
32GABAergic synapse_Homo sapiens_hsa047271.47335214
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.46833477
34Taste transduction_Homo sapiens_hsa047421.45823799
35Focal adhesion_Homo sapiens_hsa045101.43280798
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42969257
37Glutamatergic synapse_Homo sapiens_hsa047241.40808020
38Gastric acid secretion_Homo sapiens_hsa049711.39999849
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37757504
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37620464
41Gap junction_Homo sapiens_hsa045401.37098964
42Long-term depression_Homo sapiens_hsa047301.35004449
43GnRH signaling pathway_Homo sapiens_hsa049121.34634273
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34092748
45Notch signaling pathway_Homo sapiens_hsa043301.31387686
46Serotonergic synapse_Homo sapiens_hsa047261.29414807
47Proteoglycans in cancer_Homo sapiens_hsa052051.28914488
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25804933
49Shigellosis_Homo sapiens_hsa051311.25642358
50Renin secretion_Homo sapiens_hsa049241.23553983
51Biosynthesis of amino acids_Homo sapiens_hsa012301.21703535
52Dorso-ventral axis formation_Homo sapiens_hsa043201.20149027
53Glioma_Homo sapiens_hsa052141.20129242
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19960794
55Oxytocin signaling pathway_Homo sapiens_hsa049211.19394420
56Morphine addiction_Homo sapiens_hsa050321.19363841
57Small cell lung cancer_Homo sapiens_hsa052221.18795394
58Amphetamine addiction_Homo sapiens_hsa050311.18565988
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.18210796
60Adherens junction_Homo sapiens_hsa045201.18015821
61AMPK signaling pathway_Homo sapiens_hsa041521.13734615
62Hepatitis C_Homo sapiens_hsa051601.10969502
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10457920
64Estrogen signaling pathway_Homo sapiens_hsa049151.09560341
65VEGF signaling pathway_Homo sapiens_hsa043701.05869858
66Phospholipase D signaling pathway_Homo sapiens_hsa040721.04746238
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03815120
68Neurotrophin signaling pathway_Homo sapiens_hsa047221.02430606
69Axon guidance_Homo sapiens_hsa043601.01822070
70ECM-receptor interaction_Homo sapiens_hsa045121.01629203
71Huntingtons disease_Homo sapiens_hsa050161.00353104
72Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00219063
73Apoptosis_Homo sapiens_hsa042100.99917499
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97443600
75Endocytosis_Homo sapiens_hsa041440.96751259
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95257530
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.94627734
78Phagosome_Homo sapiens_hsa041450.92934425
79Prostate cancer_Homo sapiens_hsa052150.92020870
80Arginine biosynthesis_Homo sapiens_hsa002200.91477790
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.90691588
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90510565
83N-Glycan biosynthesis_Homo sapiens_hsa005100.90159000
84Hepatitis B_Homo sapiens_hsa051610.89209046
85Melanogenesis_Homo sapiens_hsa049160.88581382
86Dilated cardiomyopathy_Homo sapiens_hsa054140.88263946
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87515903
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87112181
89Insulin signaling pathway_Homo sapiens_hsa049100.87082495
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.86436377
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86395604
92Carbon metabolism_Homo sapiens_hsa012000.84998922
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84982952
94ErbB signaling pathway_Homo sapiens_hsa040120.84363369
95Cocaine addiction_Homo sapiens_hsa050300.82357103
96Calcium signaling pathway_Homo sapiens_hsa040200.82180872
97Type II diabetes mellitus_Homo sapiens_hsa049300.81358943
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80678132
99MicroRNAs in cancer_Homo sapiens_hsa052060.80637368
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79861854
101B cell receptor signaling pathway_Homo sapiens_hsa046620.78226635
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77875117
103TNF signaling pathway_Homo sapiens_hsa046680.77333929
104Osteoclast differentiation_Homo sapiens_hsa043800.76082966
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.75697995
106Colorectal cancer_Homo sapiens_hsa052100.75155661
107cAMP signaling pathway_Homo sapiens_hsa040240.74980449
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.74896437
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74099572
110Choline metabolism in cancer_Homo sapiens_hsa052310.74063990
111Melanoma_Homo sapiens_hsa052180.73319936
112Renal cell carcinoma_Homo sapiens_hsa052110.73167318
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73139485
114Thyroid cancer_Homo sapiens_hsa052160.72934853
115Malaria_Homo sapiens_hsa051440.71217578
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70718918
117Sulfur relay system_Homo sapiens_hsa041220.70071044
118Toxoplasmosis_Homo sapiens_hsa051450.69139016
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69130159
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69129028
121HIF-1 signaling pathway_Homo sapiens_hsa040660.68979762
122Salmonella infection_Homo sapiens_hsa051320.68387964
123Lysosome_Homo sapiens_hsa041420.67917935
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67688074
125Prion diseases_Homo sapiens_hsa050200.67052167
126Pancreatic secretion_Homo sapiens_hsa049720.64935668
127Ras signaling pathway_Homo sapiens_hsa040140.63586053
128Oocyte meiosis_Homo sapiens_hsa041140.63505260
129Steroid biosynthesis_Homo sapiens_hsa001000.63319700
130Insulin resistance_Homo sapiens_hsa049310.62536621
131Tight junction_Homo sapiens_hsa045300.61285757
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60671334
133Viral carcinogenesis_Homo sapiens_hsa052030.60553243
134HTLV-I infection_Homo sapiens_hsa051660.60498881
135Endometrial cancer_Homo sapiens_hsa052130.58618102
136Rap1 signaling pathway_Homo sapiens_hsa040150.58583033
137Thyroid hormone synthesis_Homo sapiens_hsa049180.57209326
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57071710
139MAPK signaling pathway_Homo sapiens_hsa040100.55850029
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54009030
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.53909478
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53496708
143Inositol phosphate metabolism_Homo sapiens_hsa005620.53048155
144Influenza A_Homo sapiens_hsa051640.52171259
145Prolactin signaling pathway_Homo sapiens_hsa049170.51190303
146Pathways in cancer_Homo sapiens_hsa052000.50721531
147Vitamin B6 metabolism_Homo sapiens_hsa007500.50445656
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48490336
149Amoebiasis_Homo sapiens_hsa051460.48356237
150Regulation of autophagy_Homo sapiens_hsa041400.48352426
151Pertussis_Homo sapiens_hsa051330.47740650
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46841924
153Lysine degradation_Homo sapiens_hsa003100.46659683
154Glucagon signaling pathway_Homo sapiens_hsa049220.46618216
155mTOR signaling pathway_Homo sapiens_hsa041500.46578544
156Rheumatoid arthritis_Homo sapiens_hsa053230.46354549
157Mineral absorption_Homo sapiens_hsa049780.45951766
158Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44588273
159Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44199861
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44135868
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43831046

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