TSPAN18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell proliferation involved in metanephros development (GO:0072203)4.41099984
2lymph vessel development (GO:0001945)4.40441873
3regulation of somitogenesis (GO:0014807)4.39499202
4lymphangiogenesis (GO:0001946)4.34538185
5neuron projection extension involved in neuron projection guidance (GO:1902284)4.23432675
6axon extension involved in axon guidance (GO:0048846)4.23432675
7endothelium development (GO:0003158)4.20539605
8regulation of non-canonical Wnt signaling pathway (GO:2000050)4.06545144
9venous blood vessel morphogenesis (GO:0048845)4.04611067
10artery development (GO:0060840)4.02298248
11endocardial cushion morphogenesis (GO:0003203)3.98027587
12paraxial mesoderm development (GO:0048339)3.94883903
13response to pheromone (GO:0019236)3.93442879
14mesenchyme morphogenesis (GO:0072132)3.82963904
15cell proliferation involved in kidney development (GO:0072111)3.81264474
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.75253106
17regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.75027032
18pyrimidine nucleobase catabolic process (GO:0006208)3.65990320
19lateral sprouting from an epithelium (GO:0060601)3.65876942
20glomerular filtration (GO:0003094)3.62361299
21Notch signaling involved in heart development (GO:0061314)3.56877422
22heart valve formation (GO:0003188)3.54380695
23cell migration involved in heart development (GO:0060973)3.49898959
24positive regulation of vasculogenesis (GO:2001214)3.49574347
25regulation of vasculogenesis (GO:2001212)3.49496622
26epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.47617858
27cell migration in hindbrain (GO:0021535)3.46938665
28cell communication by electrical coupling (GO:0010644)3.45686708
29coronary vasculature morphogenesis (GO:0060977)3.40838562
30endothelial cell differentiation (GO:0045446)3.31446905
31blood vessel maturation (GO:0001955)3.29761861
32branching involved in salivary gland morphogenesis (GO:0060445)3.29406036
33camera-type eye morphogenesis (GO:0048593)3.28547964
34vasculogenesis (GO:0001570)3.27822448
35neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.27040277
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26430772
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.25999633
38vascular endothelial growth factor signaling pathway (GO:0038084)3.23496029
39convergent extension (GO:0060026)3.23343133
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22550524
41dendritic spine morphogenesis (GO:0060997)3.19621397
42ganglion development (GO:0061548)3.19503951
43neuronal stem cell maintenance (GO:0097150)3.17969242
44tongue development (GO:0043586)3.17625843
45basement membrane organization (GO:0071711)3.16958318
46cell proliferation in forebrain (GO:0021846)3.14845962
47negative regulation of axon guidance (GO:1902668)3.14305001
48cell surface receptor signaling pathway involved in heart development (GO:0061311)3.13320909
49renal filtration (GO:0097205)3.10674662
50mesenchymal cell proliferation (GO:0010463)3.10558937
51establishment of planar polarity (GO:0001736)3.09059739
52establishment of tissue polarity (GO:0007164)3.09059739
53cerebral cortex radially oriented cell migration (GO:0021799)3.07733010
54postsynaptic membrane organization (GO:0001941)3.06312656
55neuron recognition (GO:0008038)3.05594933
56sprouting angiogenesis (GO:0002040)3.05538166
57somite development (GO:0061053)3.02431627
58regulation of endothelial cell differentiation (GO:0045601)3.00758176
59ventricular trabecula myocardium morphogenesis (GO:0003222)3.00554272
60presynaptic membrane assembly (GO:0097105)3.00011168
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99870359
62axonal fasciculation (GO:0007413)2.99789921
63spinal cord association neuron differentiation (GO:0021527)2.98613226
64lung lobe morphogenesis (GO:0060463)2.95955958
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94631113
66short-term memory (GO:0007614)2.93558967
67negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.92963140
68positive regulation of protein kinase C signaling (GO:0090037)2.90624533
69Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.90346779
70atrioventricular valve morphogenesis (GO:0003181)2.88504366
71negative regulation of protein localization to cell surface (GO:2000009)2.87981312
72sarcomere organization (GO:0045214)2.87684561
73limb bud formation (GO:0060174)2.87490683
74cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84406841
75presynaptic membrane organization (GO:0097090)2.84002498
76cardiac ventricle formation (GO:0003211)2.83729624
77myelination in peripheral nervous system (GO:0022011)2.82362904
78peripheral nervous system axon ensheathment (GO:0032292)2.82362904
79adult heart development (GO:0007512)2.79919913
80non-canonical Wnt signaling pathway (GO:0035567)2.79096605
81radial glial cell differentiation (GO:0060019)2.78846638
82patterning of blood vessels (GO:0001569)2.78826891
83polyketide metabolic process (GO:0030638)2.78670246
84doxorubicin metabolic process (GO:0044598)2.78670246
85daunorubicin metabolic process (GO:0044597)2.78670246
86notochord development (GO:0030903)2.75609198
87regulation of establishment of planar polarity (GO:0090175)2.75592786
88lung-associated mesenchyme development (GO:0060484)2.75033423
89cardiac epithelial to mesenchymal transition (GO:0060317)2.74452718
90myofibril assembly (GO:0030239)2.74426581
91spinal cord development (GO:0021510)2.71803245
92outflow tract septum morphogenesis (GO:0003148)2.71753657
93renal system development (GO:0072001)2.71422626
94surfactant homeostasis (GO:0043129)2.71320699
95stem cell development (GO:0048864)2.70247315
96heart valve morphogenesis (GO:0003179)2.69182556
97ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.67954911
98hippo signaling (GO:0035329)2.66416805
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66394248
100head development (GO:0060322)2.65575063
101embryonic foregut morphogenesis (GO:0048617)2.64560209
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63803188
103appendage development (GO:0048736)2.63323353
104limb development (GO:0060173)2.63323353
105regulation of axon extension involved in axon guidance (GO:0048841)2.62737962
106regulation of axon guidance (GO:1902667)2.62613396
107mesenchymal cell development (GO:0014031)2.61473399
108heart morphogenesis (GO:0003007)2.60696724
109regulation of mesoderm development (GO:2000380)2.60379211
110regulation of membrane repolarization (GO:0060306)2.60303280
111negative regulation of stem cell proliferation (GO:2000647)2.59406896
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58482337
113pattern specification involved in kidney development (GO:0061004)2.57962489
114bone trabecula formation (GO:0060346)2.56708272
115heart trabecula morphogenesis (GO:0061384)2.56267656
116calcium-mediated signaling using intracellular calcium source (GO:0035584)2.55422400
117positive regulation of endothelial cell differentiation (GO:0045603)2.54851291
118actin-myosin filament sliding (GO:0033275)2.54777801
119muscle filament sliding (GO:0030049)2.54777801
120positive regulation of neuroblast proliferation (GO:0002052)2.54493361
121mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.54111853
122neuron fate determination (GO:0048664)2.53931814
123cardiac chamber formation (GO:0003207)2.53534777
124negative chemotaxis (GO:0050919)2.53513487
125regulation of mesenchymal cell proliferation (GO:0010464)2.53505135
126cardiovascular system development (GO:0072358)2.53440483
127neurotransmitter-gated ion channel clustering (GO:0072578)2.53400378
128forebrain neuron differentiation (GO:0021879)2.52004966
129angiogenesis involved in wound healing (GO:0060055)2.51423503
130negative regulation of oligodendrocyte differentiation (GO:0048715)2.51400562
131dopaminergic neuron differentiation (GO:0071542)2.51326027
132atrial septum morphogenesis (GO:0060413)2.50951557
133negative regulation of vascular permeability (GO:0043116)2.50935131
134negative regulation of smooth muscle cell differentiation (GO:0051151)2.50773432
135heart trabecula formation (GO:0060347)2.50010370
136atrial cardiac muscle cell action potential (GO:0086014)2.48373079
137G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.48365256
138regulation of smooth muscle cell differentiation (GO:0051150)2.48148677
139positive regulation of vascular permeability (GO:0043117)2.48013109
140retinal ganglion cell axon guidance (GO:0031290)2.47564078
141nucleobase catabolic process (GO:0046113)2.47102888
142establishment of nucleus localization (GO:0040023)2.45647089
143sympathetic nervous system development (GO:0048485)2.45586308
144cardiac myofibril assembly (GO:0055003)2.45273163
145transmission of nerve impulse (GO:0019226)2.45272590
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44589351
147regulation of mesenchymal cell apoptotic process (GO:2001053)2.44573462
148positive regulation of neural precursor cell proliferation (GO:2000179)2.44233829
149cardiac muscle contraction (GO:0060048)2.44152733
150cranial nerve morphogenesis (GO:0021602)2.44119118
151organ formation (GO:0048645)2.43968761
152calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43836489
153artery morphogenesis (GO:0048844)2.43410265
154negative regulation of striated muscle cell apoptotic process (GO:0010664)2.42841851
155blood vessel morphogenesis (GO:0048514)2.42290341
156protein neddylation (GO:0045116)2.42225957
157trabecula formation (GO:0060343)2.42050666
158positive regulation of gastrulation (GO:2000543)2.41137631
159cardiac muscle tissue morphogenesis (GO:0055008)2.38940077
160cellular response to monoamine stimulus (GO:0071868)2.38809046
161cellular response to catecholamine stimulus (GO:0071870)2.38809046
162auditory behavior (GO:0031223)2.38473323
163regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.37701821
164outer ear morphogenesis (GO:0042473)2.37253263
165cell communication involved in cardiac conduction (GO:0086065)2.36448063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.62411757
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.08359952
3GBX2_23144817_ChIP-Seq_PC3_Human3.05288684
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.70976070
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61077988
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61077988
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58962884
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58137131
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57210773
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.51267975
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36859162
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.35761181
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32307890
14RNF2_27304074_Chip-Seq_ESCs_Mouse2.32158160
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31994150
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.28922014
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28819241
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26744790
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24643377
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24571456
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24260694
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20741570
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20022402
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.19904980
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.97404047
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93031781
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.92901907
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90584756
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82901788
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79575313
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76592363
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74765861
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73966873
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73332529
35DROSHA_22980978_ChIP-Seq_HELA_Human1.72624620
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.71686707
37OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.71465595
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68437654
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.66822711
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.66513432
41* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65775629
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.60778847
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60429197
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58326065
45* P300_19829295_ChIP-Seq_ESCs_Human1.52422667
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50681266
47* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49890151
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49153513
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.47286656
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44384318
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.44160408
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40074600
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.38390403
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36961218
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.36759590
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36434646
57REST_21632747_ChIP-Seq_MESCs_Mouse1.36022093
58SMAD4_21799915_ChIP-Seq_A2780_Human1.34903739
59* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34453505
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.33203959
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31722676
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31448299
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30289888
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.30070752
65* KDM2B_26808549_Chip-Seq_K562_Human1.29726520
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29646544
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.29507060
68CTCF_27219007_Chip-Seq_Bcells_Human1.29424396
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29181299
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.27970822
71AHR_22903824_ChIP-Seq_MCF-7_Human1.27502526
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.26878042
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25166205
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23705770
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23137938
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23137938
77RNF2_27304074_Chip-Seq_NSC_Mouse1.22871705
78ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22841758
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22364726
80* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21308199
81TP53_18474530_ChIP-ChIP_U2OS_Human1.21034366
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18460209
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.18242800
84* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17673515
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17518015
86IGF1R_20145208_ChIP-Seq_DFB_Human1.16804734
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16132380
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15905267
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14494499
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.13737551
91TAF15_26573619_Chip-Seq_HEK293_Human1.13609249
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13146149
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13109881
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13081909
95* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13059649
96* E2F1_18555785_Chip-Seq_ESCs_Mouse1.12557097
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.11950742
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.11784452
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11345323
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11278459
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11042801
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10759639
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.09945831
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09125172
105* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08368489
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08292671
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08031588
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07356896
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07212351
110CJUN_26792858_Chip-Seq_BT549_Human1.06014230
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.05994732
112AR_21572438_ChIP-Seq_LNCaP_Human1.05692142
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05141406
114EWS_26573619_Chip-Seq_HEK293_Human1.04848526
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04595624
116* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03783622
117STAT3_23295773_ChIP-Seq_U87_Human1.03734961
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03606058
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03058445
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.02636553
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02427860
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01577081
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01461027
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00991509
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.00912456
126TP53_16413492_ChIP-PET_HCT116_Human1.00344869
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00043673
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99501197
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96996203
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95994040
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95587421
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95103726
133SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94536085
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94418068
135AR_19668381_ChIP-Seq_PC3_Human0.93807865
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93322514
137* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92891944
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.92534259
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91551444
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90479146
141TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90285251
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88381196
143NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88186193
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.87789779
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87090133
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85848471
147RARB_27405468_Chip-Seq_BRAIN_Mouse0.85462690
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.84814969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.84485574
2MP0003122_maternal_imprinting4.52778001
3MP0001879_abnormal_lymphatic_vessel3.90145897
4MP0000566_synostosis3.73115443
5MP0004272_abnormal_basement_membrane3.66994290
6MP0005167_abnormal_blood-brain_barrier2.82533453
7MP0003136_yellow_coat_color2.41012149
8MP0003121_genomic_imprinting2.33750733
9MP0002102_abnormal_ear_morphology2.32061208
10MP0004084_abnormal_cardiac_muscle2.24290985
11MP0010030_abnormal_orbit_morphology2.24276070
12MP0003828_pulmonary_edema2.09310712
13MP0000537_abnormal_urethra_morphology1.95821717
14MP0006138_congestive_heart_failure1.85352751
15MP0000383_abnormal_hair_follicle1.83561253
16MP0003279_aneurysm1.76035256
17MP0002938_white_spotting1.70360294
18MP0005171_absent_coat_pigmentation1.69775420
19MP0002822_catalepsy1.69259940
20MP0004859_abnormal_synaptic_plasticity1.68080881
21MP0002653_abnormal_ependyma_morphology1.67667502
22MP0003385_abnormal_body_wall1.66696744
23MP0005499_abnormal_olfactory_system1.65583855
24MP0005394_taste/olfaction_phenotype1.65583855
25MP0004215_abnormal_myocardial_fiber1.65363000
26MP0000049_abnormal_middle_ear1.65011604
27MP0000767_abnormal_smooth_muscle1.63539116
28MP0009697_abnormal_copulation1.61317510
29MP0005377_hearing/vestibular/ear_phenot1.59374790
30MP0003878_abnormal_ear_physiology1.59374790
31MP0002249_abnormal_larynx_morphology1.57025157
32MP0002127_abnormal_cardiovascular_syste1.51438610
33MP0008789_abnormal_olfactory_epithelium1.49135053
34MP0004885_abnormal_endolymph1.48492617
35MP0008775_abnormal_heart_ventricle1.46723285
36MP0009379_abnormal_foot_pigmentation1.46225214
37MP0003941_abnormal_skin_development1.43609699
38MP0003119_abnormal_digestive_system1.42342917
39MP0003283_abnormal_digestive_organ1.41003825
40MP0001346_abnormal_lacrimal_gland1.39592068
41MP0003935_abnormal_craniofacial_develop1.37825901
42MP0008004_abnormal_stomach_pH1.37701257
43MP0009250_abnormal_appendicular_skeleto1.34747272
44MP0002837_dystrophic_cardiac_calcinosis1.33597664
45MP0003567_abnormal_fetal_cardiomyocyte1.30919407
46MP0005503_abnormal_tendon_morphology1.30829960
47MP0005409_darkened_coat_color1.28155717
48MP0002282_abnormal_trachea_morphology1.26739554
49MP0009053_abnormal_anal_canal1.25228991
50MP0001188_hyperpigmentation1.24520407
51MP0004145_abnormal_muscle_electrophysio1.23401958
52MP0005670_abnormal_white_adipose1.22710282
53MP0001270_distended_abdomen1.21986418
54MP0002925_abnormal_cardiovascular_devel1.20876414
55MP0003942_abnormal_urinary_system1.20376060
56MP0003861_abnormal_nervous_system1.20292900
57MP0003938_abnormal_ear_development1.18965003
58MP0004085_abnormal_heartbeat1.18583409
59MP0000631_abnormal_neuroendocrine_gland1.18126583
60MP0002092_abnormal_eye_morphology1.18062784
61MP0002233_abnormal_nose_morphology1.17972325
62MP0002972_abnormal_cardiac_muscle1.17713485
63MP0004130_abnormal_muscle_cell1.16608005
64MP0000778_abnormal_nervous_system1.15460077
65MP0005385_cardiovascular_system_phenoty1.14396459
66MP0001544_abnormal_cardiovascular_syste1.14396459
67MP0002932_abnormal_joint_morphology1.13258866
68MP0001485_abnormal_pinna_reflex1.11289908
69MP0003937_abnormal_limbs/digits/tail_de1.10863582
70MP0005623_abnormal_meninges_morphology1.10396578
71MP0004484_altered_response_of1.09663587
72MP0005248_abnormal_Harderian_gland1.09241969
73MP0003115_abnormal_respiratory_system1.08627201
74MP0001299_abnormal_eye_distance/1.07309980
75MP0010630_abnormal_cardiac_muscle1.06502695
76MP0002116_abnormal_craniofacial_bone1.05624124
77MP0002697_abnormal_eye_size1.05213926
78MP0000955_abnormal_spinal_cord1.04616282
79MP0003315_abnormal_perineum_morphology1.04515189
80MP0004036_abnormal_muscle_relaxation1.04263138
81MP0005257_abnormal_intraocular_pressure1.04211582
82MP0000428_abnormal_craniofacial_morphol1.03919972
83MP0000751_myopathy1.03792676
84MP0003787_abnormal_imprinting1.03382674
85MP0000762_abnormal_tongue_morphology1.02817254
86MP0005595_abnormal_vascular_smooth1.02569004
87MP0002751_abnormal_autonomic_nervous1.02358082
88MP0002152_abnormal_brain_morphology0.99982088
89MP0005645_abnormal_hypothalamus_physiol0.99981094
90MP0005620_abnormal_muscle_contractility0.99712059
91MP0004858_abnormal_nervous_system0.99357569
92MP0000026_abnormal_inner_ear0.97036181
93MP0001293_anophthalmia0.96885286
94MP0003755_abnormal_palate_morphology0.96287876
95MP0000266_abnormal_heart_morphology0.94311458
96MP0001614_abnormal_blood_vessel0.94143698
97MP0002128_abnormal_blood_circulation0.93619893
98MP0006292_abnormal_olfactory_placode0.93028682
99MP0010678_abnormal_skin_adnexa0.92413764
100MP0004133_heterotaxia0.92385091
101MP0003880_abnormal_central_pattern0.91984923
102MP0006276_abnormal_autonomic_nervous0.91585045
103MP0002638_abnormal_pupillary_reflex0.91540423
104MP0005423_abnormal_somatic_nervous0.90535952
105MP0000534_abnormal_ureter_morphology0.90230066
106MP0001984_abnormal_olfaction0.89571844
107MP0002109_abnormal_limb_morphology0.88141215
108MP0005330_cardiomyopathy0.86679168
109MP0003137_abnormal_impulse_conducting0.84738190
110MP0005187_abnormal_penis_morphology0.83898241
111MP0003045_fibrosis0.83220473
112MP0002063_abnormal_learning/memory/cond0.82582812
113MP0003635_abnormal_synaptic_transmissio0.82121896
114MP0002081_perinatal_lethality0.81329889
115MP0002277_abnormal_respiratory_mucosa0.81289748
116MP0002752_abnormal_somatic_nervous0.81222837
117MP0004233_abnormal_muscle_weight0.81200704
118MP0002882_abnormal_neuron_morphology0.81181139
119MP0000465_gastrointestinal_hemorrhage0.80569850
120MP0003705_abnormal_hypodermis_morpholog0.79944218
121MP0003890_abnormal_embryonic-extraembry0.79782604
122MP0001849_ear_inflammation0.79679943
123MP0001486_abnormal_startle_reflex0.79593036
124MP0001286_abnormal_eye_development0.78591644
125MP0002108_abnormal_muscle_morphology0.78400168
126MP0004087_abnormal_muscle_fiber0.77986624
127MP0000462_abnormal_digestive_system0.77962008
128MP0000647_abnormal_sebaceous_gland0.77576757
129MP0004510_myositis0.75105361
130MP0004142_abnormal_muscle_tone0.74113356
131MP0002098_abnormal_vibrissa_morphology0.73520671
132MP0000432_abnormal_head_morphology0.72308192
133MP0002184_abnormal_innervation0.71955329
134MP0002163_abnormal_gland_morphology0.71484029
135MP0008438_abnormal_cutaneous_collagen0.68771594
136MP0000733_abnormal_muscle_development0.67924393
137MP0000163_abnormal_cartilage_morphology0.67387510

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.81883050
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.81883050
3Aplasia cutis congenita (HP:0001057)3.49620876
4Midline defect of the nose (HP:0004122)3.46999169
5Absent eyebrow (HP:0002223)3.45679962
6Skull defect (HP:0001362)3.27807770
7Broad metatarsal (HP:0001783)3.20980254
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13134106
9Asymmetry of the thorax (HP:0001555)3.12677933
10Partial duplication of thumb phalanx (HP:0009944)2.99441398
11Pulmonary artery stenosis (HP:0004415)2.92301341
12Anterior segment dysgenesis (HP:0007700)2.86035631
13Abnormality of the aortic arch (HP:0012303)2.80214284
14Bilateral microphthalmos (HP:0007633)2.71194747
15Absent eyelashes (HP:0000561)2.70408150
16Turricephaly (HP:0000262)2.68983846
17Chromsome breakage (HP:0040012)2.68614283
18Abnormality of the right ventricle (HP:0001707)2.67933822
19Lymphangioma (HP:0100764)2.67280600
20Partial duplication of the phalanx of hand (HP:0009999)2.66124448
21Abnormality of the ischium (HP:0003174)2.64002400
22Hepatoblastoma (HP:0002884)2.62301999
23Abnormality of the 4th metacarpal (HP:0010012)2.60983736
24Menorrhagia (HP:0000132)2.59016636
25Trigonocephaly (HP:0000243)2.58878539
26Increased mean platelet volume (HP:0011877)2.57450711
27Atrial fibrillation (HP:0005110)2.55037942
28Prolonged bleeding time (HP:0003010)2.53356072
29Abnormality of the diencephalon (HP:0010662)2.48381903
30Myokymia (HP:0002411)2.46299920
31Cutaneous finger syndactyly (HP:0010554)2.40633687
32Rib fusion (HP:0000902)2.40593550
33Anophthalmia (HP:0000528)2.40117300
34Abnormality of the parietal bone (HP:0002696)2.38687329
35Abnormal number of incisors (HP:0011064)2.37821789
36Abnormality of the renal collecting system (HP:0004742)2.36750876
37High anterior hairline (HP:0009890)2.34549152
38Primary atrial arrhythmia (HP:0001692)2.34008285
39Duplicated collecting system (HP:0000081)2.32181323
40Supraventricular arrhythmia (HP:0005115)2.31571735
41Broad thumb (HP:0011304)2.30138339
42Ectopic kidney (HP:0000086)2.29227027
43Adactyly (HP:0009776)2.29126554
44Abnormal platelet volume (HP:0011876)2.28542208
45Morphological abnormality of the middle ear (HP:0008609)2.26397395
46Narrow nasal bridge (HP:0000446)2.25397957
47Optic nerve hypoplasia (HP:0000609)2.25345251
48Thyroid-stimulating hormone excess (HP:0002925)2.24733847
49Long eyelashes (HP:0000527)2.24710938
50Mesomelia (HP:0003027)2.23251076
51Renal duplication (HP:0000075)2.22685784
52Limited hip movement (HP:0008800)2.20979277
53Myelomeningocele (HP:0002475)2.20408071
54Supraventricular tachycardia (HP:0004755)2.19823732
55Sudden death (HP:0001699)2.17275440
56Porencephaly (HP:0002132)2.15219451
57Shallow orbits (HP:0000586)2.13222885
58Muscle fiber splitting (HP:0003555)2.12937451
59Cutaneous syndactyly (HP:0012725)2.12579154
60Vertebral clefting (HP:0008428)2.11619647
61Ventricular tachycardia (HP:0004756)2.11599669
62Spontaneous hematomas (HP:0007420)2.11276650
63Abnormality of the lacrimal duct (HP:0011481)2.08135275
64Abnormality of the nasal septum (HP:0000419)2.06920109
65Broad phalanges of the hand (HP:0009768)2.04438654
66Aortic aneurysm (HP:0004942)2.02558201
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02290518
68Renal dysplasia (HP:0000110)2.01088067
69Protrusio acetabuli (HP:0003179)2.00954491
70Abnormality of the nasolacrimal system (HP:0000614)1.99646668
71Broad finger (HP:0001500)1.99603231
72Abnormality of the intervertebral disk (HP:0005108)1.99510436
73Wrist flexion contracture (HP:0001239)1.99212814
74Oligodactyly (HP:0012165)1.99113562
75Supernumerary bones of the axial skeleton (HP:0009144)1.98121913
76Abnormality of the incisor (HP:0000676)1.97557306
77Exotropia (HP:0000577)1.96983901
78Preaxial foot polydactyly (HP:0001841)1.96523560
79Bundle branch block (HP:0011710)1.96033801
80Increased number of teeth (HP:0011069)1.95572113
81Wide anterior fontanel (HP:0000260)1.95523910
82Abnormality of incisor morphology (HP:0011063)1.94974140
83Maternal diabetes (HP:0009800)1.93708159
84Absent septum pellucidum (HP:0001331)1.91885009
85Hypoplasia of the iris (HP:0007676)1.90750916
86Follicular hyperkeratosis (HP:0007502)1.90259404
87Bronchomalacia (HP:0002780)1.89050362
88Heart block (HP:0012722)1.88162523
89Nasolacrimal duct obstruction (HP:0000579)1.88044757
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87609259
91Broad phalanx (HP:0006009)1.86869093
92Cerebral aneurysm (HP:0004944)1.86617768
93Neoplasm of the heart (HP:0100544)1.85793906
94Abnormality of the anterior chamber (HP:0000593)1.85784035
95Metaphyseal cupping (HP:0003021)1.84384851
96White forelock (HP:0002211)1.83389984
97Absent hair (HP:0002298)1.83173555
98Vascular tortuosity (HP:0004948)1.82619010
99Thin ribs (HP:0000883)1.82430902
100Arterial tortuosity (HP:0005116)1.80587507
101Broad toe (HP:0001837)1.80184335
102Absent hand (HP:0004050)1.79470081
103Septo-optic dysplasia (HP:0100842)1.79438414
104Increased variability in muscle fiber diameter (HP:0003557)1.78750833
105Capillary hemangiomas (HP:0005306)1.78352954
106Broad long bones (HP:0005622)1.78104394
107Coronal craniosynostosis (HP:0004440)1.77706340
108Anal stenosis (HP:0002025)1.76359409
109Bifid tongue (HP:0010297)1.74584126
110Enlarged penis (HP:0000040)1.74298091
111Congenital sensorineural hearing impairment (HP:0008527)1.73875083
112Lipoatrophy (HP:0100578)1.73640533
113Aplasia involving bones of the extremities (HP:0009825)1.73344577
114Aplasia involving bones of the upper limbs (HP:0009823)1.73344577
115Aplasia of the phalanges of the hand (HP:0009802)1.73344577
116Hyporeflexia of lower limbs (HP:0002600)1.72490406
117Recurrent corneal erosions (HP:0000495)1.72101794
118Aortic dissection (HP:0002647)1.72038614
119Irregular epiphyses (HP:0010582)1.71657612
120Shawl scrotum (HP:0000049)1.70761595
121Unilateral renal agenesis (HP:0000122)1.69842930
122Syncope (HP:0001279)1.69468208
123Flat cornea (HP:0007720)1.68970589
124Narrow palate (HP:0000189)1.68793837
125Hypoplastic ischia (HP:0003175)1.68389413
126Elfin facies (HP:0004428)1.67782101
127Renal hypoplasia (HP:0000089)1.67464005
128Broad palm (HP:0001169)1.67122557
129Atrioventricular block (HP:0001678)1.66536325
130Hyperlipoproteinemia (HP:0010980)1.65468534
131Prolonged QT interval (HP:0001657)1.65289527
132Tented upper lip vermilion (HP:0010804)1.64774541
133Patchy hypopigmentation of hair (HP:0011365)1.63974716
134Sprengel anomaly (HP:0000912)1.63156865
135Abnormality of the septum pellucidum (HP:0007375)1.62442666
136Abnormality of the carotid arteries (HP:0005344)1.62361053
137Abnormality of the pubic bones (HP:0003172)1.61620464
138Portal hypertension (HP:0001409)1.61447780
139Abnormality of the labia minora (HP:0012880)1.61218567
140Hemivertebrae (HP:0002937)1.61140866
141Increased corneal curvature (HP:0100692)1.61109169
142Keratoconus (HP:0000563)1.61109169
143Abnormal atrioventricular conduction (HP:0005150)1.59271160
144Hip contracture (HP:0003273)1.59211295
145Growth hormone deficiency (HP:0000824)1.59110652
146Aqueductal stenosis (HP:0002410)1.58978926
147Tracheomalacia (HP:0002779)1.58425420
148Supernumerary ribs (HP:0005815)1.58282537
149Vertebral arch anomaly (HP:0008438)1.57502568
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.57210697
151Vitreoretinal degeneration (HP:0000655)1.57082764
152Esophageal atresia (HP:0002032)1.55255294
153Choanal stenosis (HP:0000452)1.55059281
154Broad hallux (HP:0010055)1.54831955
155Abnormality of the distal phalanx of the thumb (HP:0009617)1.54538312
156Renovascular hypertension (HP:0100817)1.54478091
157Abnormal vertebral ossification (HP:0100569)1.53641671
158Duplication of thumb phalanx (HP:0009942)1.53239528
159Abnormality of the hepatic vasculature (HP:0006707)1.52646035
160Difficulty running (HP:0009046)1.52434376
161Overfolded helix (HP:0000396)1.52427875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.79053400
2SIK34.66566364
3EPHB24.27974169
4KDR4.13089255
5TGFBR22.82108300
6MARK12.44864632
7LATS12.41491465
8TYRO32.32470277
9SIK22.29387566
10DMPK2.09169757
11SIK12.07752130
12MAP3K101.97563845
13DYRK21.92750173
14CAMK1D1.92599565
15CAMK1G1.86775376
16GRK11.75155110
17INSRR1.72162188
18PNCK1.71171305
19TGFBR11.70759196
20ZAK1.70355079
21KSR11.67420320
22PTK2B1.52230827
23NTRK11.48147946
24NUAK11.47084544
25BRD41.41381030
26CDK121.40489742
27ERBB21.39309453
28TTN1.38619381
29BMX1.35024975
30EIF2AK21.33079769
31STK38L1.29973304
32BCR1.29713003
33SGK2231.20148186
34SGK4941.20148186
35CDK81.19167929
36YES11.18740225
37DYRK1B1.18189492
38EPHA41.13260824
39LMTK21.11538466
40OBSCN1.05592186
41FES1.03472247
42FER0.99468770
43CDK30.98624958
44PRKAA20.95936757
45FGFR20.95445656
46MAPK130.95021507
47NTRK30.93919895
48MYLK0.90677055
49PRKD30.90529109
50PAK30.88798341
51CASK0.88293830
52BMPR1B0.88065040
53MARK30.88004326
54STK240.84903589
55AKT20.83753804
56PAK40.83333290
57DYRK1A0.82267851
58NLK0.79039718
59IRAK10.77847990
60MAP3K70.75597860
61STK110.74548566
62CDK190.73680975
63WNK30.73125936
64STK30.72337414
65FGFR10.71940226
66RPS6KA20.68064859
67DYRK30.66739887
68MARK20.66015503
69CAMK10.65899712
70CDK70.64924304
71PRPF4B0.63811382
72TNIK0.63696938
73CDK50.63640597
74PINK10.63013010
75NEK20.61482828
76RIPK10.61018976
77LATS20.60887668
78IRAK20.59280103
79BTK0.58671551
80RET0.58227990
81SRPK10.58020628
82ROCK20.57401416
83PRKCG0.57187870
84CDC42BPA0.56400971
85PLK20.55952355
86EPHB10.54719773
87SGK30.54673023
88ROCK10.53956203
89PDGFRB0.53758932
90CAMK40.52704127
91ERBB30.51770075
92MAP3K90.51342134
93DDR20.50981210
94PIK3CA0.50946222
95WNK10.49903258
96PRKCE0.49105495
97CDK90.49101380
98MAPK70.48763788
99GRK50.48206746
100MAP3K40.47837803
101PTK20.47072899
102SGK20.46354261
103AKT30.46034150
104CSNK1A1L0.45901923
105ICK0.45761578
106MAP2K40.45668988
107ATR0.45638275
108NTRK20.45595279
109PRKCH0.45419240
110AKT10.44310988
111IGF1R0.43698192
112PTK60.43673907
113FGFR40.41963993
114MAPK150.41872305
115MAP3K60.41636970
116CHEK20.41014950
117LRRK20.40503793
118EPHA30.39408333
119NEK90.39105477
120PRKCZ0.38525101
121SRC0.38429364
122PHKG20.37761912
123PHKG10.37761912
124PRKG20.36876192
125RPS6KL10.36398176
126RPS6KC10.36398176
127PRKAA10.35002793
128PDGFRA0.34739753
129PKN10.34491649
130MINK10.33752894
131MTOR0.33687394
132CAMK2A0.33270094
133PRKD10.32418592
134FGFR30.31561330
135MAPK120.30117304
136ADRBK20.28943695
137GRK70.28505291
138IRAK40.28270616
139MKNK20.26739452
140PRKG10.26031194
141TEC0.25834584
142MKNK10.25268552
143PLK40.24968905
144NEK60.24690474
145UHMK10.24617858
146SGK10.24138899

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.06251286
2Notch signaling pathway_Homo sapiens_hsa043302.34241114
3Axon guidance_Homo sapiens_hsa043602.27645822
4Dilated cardiomyopathy_Homo sapiens_hsa054142.20587983
5ECM-receptor interaction_Homo sapiens_hsa045122.20526171
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.10101170
7Hedgehog signaling pathway_Homo sapiens_hsa043402.08314279
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.06791130
9Hippo signaling pathway_Homo sapiens_hsa043902.03433825
10Adherens junction_Homo sapiens_hsa045201.98363488
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74562476
12Wnt signaling pathway_Homo sapiens_hsa043101.65961681
13Lysine degradation_Homo sapiens_hsa003101.62274074
14Focal adhesion_Homo sapiens_hsa045101.55769244
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54430930
16Ovarian steroidogenesis_Homo sapiens_hsa049131.51252566
17Dorso-ventral axis formation_Homo sapiens_hsa043201.49860097
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48665110
19Small cell lung cancer_Homo sapiens_hsa052221.47473976
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41913068
21Viral myocarditis_Homo sapiens_hsa054161.39885894
22Fanconi anemia pathway_Homo sapiens_hsa034601.37433430
23MicroRNAs in cancer_Homo sapiens_hsa052061.37092157
24TGF-beta signaling pathway_Homo sapiens_hsa043501.34118228
25GABAergic synapse_Homo sapiens_hsa047271.31923186
26Rap1 signaling pathway_Homo sapiens_hsa040151.31517331
27Melanogenesis_Homo sapiens_hsa049161.27008745
28Pathways in cancer_Homo sapiens_hsa052001.25349832
29Renin secretion_Homo sapiens_hsa049241.24468822
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23362479
31Circadian entrainment_Homo sapiens_hsa047131.20778603
32Calcium signaling pathway_Homo sapiens_hsa040201.20289674
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19393655
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19014104
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18731497
36cAMP signaling pathway_Homo sapiens_hsa040241.17217962
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16784084
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14774055
39Thyroid hormone synthesis_Homo sapiens_hsa049181.11825944
40Protein digestion and absorption_Homo sapiens_hsa049741.11307213
41Gastric acid secretion_Homo sapiens_hsa049711.09742708
42Nicotine addiction_Homo sapiens_hsa050331.05089410
43Morphine addiction_Homo sapiens_hsa050321.04422828
44Proteoglycans in cancer_Homo sapiens_hsa052051.03849731
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01543589
46Dopaminergic synapse_Homo sapiens_hsa047281.00476887
47Melanoma_Homo sapiens_hsa052181.00208042
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99068088
49Taste transduction_Homo sapiens_hsa047420.96714756
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.96660108
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95469065
52Tight junction_Homo sapiens_hsa045300.94369456
53Cell cycle_Homo sapiens_hsa041100.92441190
54HTLV-I infection_Homo sapiens_hsa051660.92076888
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.91486023
56VEGF signaling pathway_Homo sapiens_hsa043700.90426346
57Homologous recombination_Homo sapiens_hsa034400.89754869
58Ras signaling pathway_Homo sapiens_hsa040140.87309065
59Cholinergic synapse_Homo sapiens_hsa047250.86704539
60Fatty acid biosynthesis_Homo sapiens_hsa000610.83476371
61Serotonergic synapse_Homo sapiens_hsa047260.83444758
62Gap junction_Homo sapiens_hsa045400.82163999
63Prostate cancer_Homo sapiens_hsa052150.79803508
64Pancreatic cancer_Homo sapiens_hsa052120.79261327
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78395955
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78198168
67Ribosome_Homo sapiens_hsa030100.76057592
68Oxytocin signaling pathway_Homo sapiens_hsa049210.75608905
69Type II diabetes mellitus_Homo sapiens_hsa049300.74448438
70Colorectal cancer_Homo sapiens_hsa052100.73539163
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73181722
72Glutamatergic synapse_Homo sapiens_hsa047240.72971422
73Renal cell carcinoma_Homo sapiens_hsa052110.72814212
74Thyroid cancer_Homo sapiens_hsa052160.71255243
75Fatty acid metabolism_Homo sapiens_hsa012120.69704405
76Insulin secretion_Homo sapiens_hsa049110.66094060
77Long-term potentiation_Homo sapiens_hsa047200.65958206
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64680314
79ErbB signaling pathway_Homo sapiens_hsa040120.64630231
80Propanoate metabolism_Homo sapiens_hsa006400.63460905
81Platelet activation_Homo sapiens_hsa046110.63344180
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63235296
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.60681522
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59199222
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59190215
86Amphetamine addiction_Homo sapiens_hsa050310.58779751
87Alcoholism_Homo sapiens_hsa050340.58753912
88Olfactory transduction_Homo sapiens_hsa047400.58586761
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58220151
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.57915501
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56928342
92Amoebiasis_Homo sapiens_hsa051460.56855368
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56770986
94Chronic myeloid leukemia_Homo sapiens_hsa052200.56757141
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53961918
96FoxO signaling pathway_Homo sapiens_hsa040680.53888507
97HIF-1 signaling pathway_Homo sapiens_hsa040660.53828557
98Circadian rhythm_Homo sapiens_hsa047100.53601029
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53576231
100African trypanosomiasis_Homo sapiens_hsa051430.51973287
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51687829
102GnRH signaling pathway_Homo sapiens_hsa049120.50494119
103Toxoplasmosis_Homo sapiens_hsa051450.49975982
104Cocaine addiction_Homo sapiens_hsa050300.49967885
105Estrogen signaling pathway_Homo sapiens_hsa049150.49879505
106Long-term depression_Homo sapiens_hsa047300.49801080
107mRNA surveillance pathway_Homo sapiens_hsa030150.49329972
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48944250
109Insulin signaling pathway_Homo sapiens_hsa049100.48921854
110Salivary secretion_Homo sapiens_hsa049700.48809112
111Pancreatic secretion_Homo sapiens_hsa049720.48502715
112Endometrial cancer_Homo sapiens_hsa052130.47758421
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.47757264
114Renin-angiotensin system_Homo sapiens_hsa046140.47596472
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47575857
116Chemokine signaling pathway_Homo sapiens_hsa040620.47353713
117Phototransduction_Homo sapiens_hsa047440.46475243
118Choline metabolism in cancer_Homo sapiens_hsa052310.45284365
119AMPK signaling pathway_Homo sapiens_hsa041520.45233855
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45172529
121Endocytosis_Homo sapiens_hsa041440.44500986
122MAPK signaling pathway_Homo sapiens_hsa040100.43991627
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43724414
124Cardiac muscle contraction_Homo sapiens_hsa042600.42961795
125Glioma_Homo sapiens_hsa052140.42893166

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