TSPAN19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)8.64660061
2left/right pattern formation (GO:0060972)7.62399033
3left/right axis specification (GO:0070986)7.18558354
4intraciliary transport (GO:0042073)6.56303796
5cilium organization (GO:0044782)6.24236301
6cilium assembly (GO:0042384)6.03964779
7ventricular system development (GO:0021591)6.02228941
8microtubule bundle formation (GO:0001578)5.93598685
9protein localization to cilium (GO:0061512)5.41181732
10vitamin transmembrane transport (GO:0035461)5.20366269
11primary alcohol catabolic process (GO:0034310)5.17179881
12regulation of microtubule-based movement (GO:0060632)5.16868092
13cilium morphogenesis (GO:0060271)5.15375039
14cellular component assembly involved in morphogenesis (GO:0010927)4.77312080
15centriole assembly (GO:0098534)4.66665906
16diterpenoid biosynthetic process (GO:0016102)4.61311500
17response to xenobiotic stimulus (GO:0009410)4.48610979
18microtubule-based movement (GO:0007018)4.45061006
19ethanol metabolic process (GO:0006067)4.37998254
20cell projection assembly (GO:0030031)4.16376882
21pyrimidine-containing compound transmembrane transport (GO:0072531)4.10794019
22one-carbon compound transport (GO:0019755)3.86872902
23lateral ventricle development (GO:0021670)3.82643939
24cornea development in camera-type eye (GO:0061303)3.79712313
25negative regulation of T cell differentiation in thymus (GO:0033085)3.78479228
26retinal cone cell development (GO:0046549)3.70022047
27retinoic acid metabolic process (GO:0042573)3.68502507
28photoreceptor cell maintenance (GO:0045494)3.68191569
29microtubule depolymerization (GO:0007019)3.67885516
30exogenous drug catabolic process (GO:0042738)3.67821353
31nucleoside diphosphate phosphorylation (GO:0006165)3.62039269
32regulation of interleukin-5 production (GO:0032674)3.59736438
33terpenoid biosynthetic process (GO:0016114)3.58878220
34centriole replication (GO:0007099)3.54955254
35nonmotile primary cilium assembly (GO:0035058)3.54726598
36determination of left/right symmetry (GO:0007368)3.49498692
37microtubule polymerization or depolymerization (GO:0031109)3.44951585
38regulation of germinal center formation (GO:0002634)3.44834450
39negative regulation of immunoglobulin mediated immune response (GO:0002890)3.38250450
40negative regulation of B cell mediated immunity (GO:0002713)3.38250450
41smoothened signaling pathway (GO:0007224)3.36144879
42determination of bilateral symmetry (GO:0009855)3.34522147
43retinal rod cell development (GO:0046548)3.32949005
44lung epithelium development (GO:0060428)3.27747028
45sperm motility (GO:0030317)3.25883641
46specification of symmetry (GO:0009799)3.25793958
47negative regulation of humoral immune response (GO:0002921)3.25176644
48tolerance induction (GO:0002507)3.23720165
49cytoplasmic microtubule organization (GO:0031122)3.21740088
50sperm capacitation (GO:0048240)3.14132541
51protein polyglutamylation (GO:0018095)3.11736926
52drug catabolic process (GO:0042737)3.10875320
53neural tube formation (GO:0001841)3.08929949
54ethanol oxidation (GO:0006069)3.07894850
55aldehyde catabolic process (GO:0046185)2.91506119
56glomerular epithelial cell development (GO:0072310)2.88123926
57glutathione derivative metabolic process (GO:1901685)2.85639361
58glutathione derivative biosynthetic process (GO:1901687)2.85639361
59regulation of interleukin-13 production (GO:0032656)2.85172534
60regulation of collateral sprouting (GO:0048670)2.83566927
61lateral sprouting from an epithelium (GO:0060601)2.81714954
62rRNA catabolic process (GO:0016075)2.78939852
63negative regulation of inclusion body assembly (GO:0090084)2.70286282
64organic cation transport (GO:0015695)2.69787286
65microtubule-based process (GO:0007017)2.68218879
66organelle assembly (GO:0070925)2.64459270
67retinol metabolic process (GO:0042572)2.63086631
68benzene-containing compound metabolic process (GO:0042537)2.62123595
69establishment of planar polarity (GO:0001736)2.55961895
70establishment of tissue polarity (GO:0007164)2.55961895
71establishment of apical/basal cell polarity (GO:0035089)2.55239785
72establishment or maintenance of monopolar cell polarity (GO:0061339)2.54916724
73establishment of monopolar cell polarity (GO:0061162)2.54916724
74neurotransmitter metabolic process (GO:0042133)2.54529284
75neurotransmitter biosynthetic process (GO:0042136)2.53732354
76photoreceptor cell development (GO:0042461)2.51964654
77phosphatidylcholine biosynthetic process (GO:0006656)2.49879362
78primary alcohol metabolic process (GO:0034308)2.49489436
79positive regulation of tolerance induction (GO:0002645)2.48914776
80positive regulation of smoothened signaling pathway (GO:0045880)2.41768772
81carnitine metabolic process (GO:0009437)2.40933582
82heart looping (GO:0001947)2.39072514
83sialylation (GO:0097503)2.37514187
84O-glycan processing (GO:0016266)2.36450797
85limb development (GO:0060173)2.36050736
86appendage development (GO:0048736)2.36050736
87eye photoreceptor cell development (GO:0042462)2.35860862
88spinal cord motor neuron differentiation (GO:0021522)2.32075205
89hydrogen peroxide biosynthetic process (GO:0050665)2.31578633
90phosphatidylethanolamine biosynthetic process (GO:0006646)2.22742408
91regulation of microtubule depolymerization (GO:0031114)2.22300685
92thyroid hormone metabolic process (GO:0042403)2.18906417
93thyroid hormone generation (GO:0006590)2.16072828
94axonemal dynein complex assembly (GO:0070286)18.4396740
95cilium or flagellum-dependent cell motility (GO:0001539)17.0258207
96cilium movement (GO:0003341)14.7392981
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.3600896
98epithelial cilium movement (GO:0003351)12.9857712
99motile cilium assembly (GO:0044458)12.4551526
100axoneme assembly (GO:0035082)10.1450142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.52158226
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04061222
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.40443239
4DROSHA_22980978_ChIP-Seq_HELA_Human2.40120600
5ZNF274_21170338_ChIP-Seq_K562_Hela2.36680326
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17972141
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.17766935
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11500247
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05756214
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04336560
11NR3C1_21868756_ChIP-Seq_MCF10A_Human1.99366296
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95783307
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88667857
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85334321
15GBX2_23144817_ChIP-Seq_PC3_Human1.83982202
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82805399
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80295296
18IGF1R_20145208_ChIP-Seq_DFB_Human1.78429345
19TAF15_26573619_Chip-Seq_HEK293_Human1.77662409
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72498872
21* SMAD4_21799915_ChIP-Seq_A2780_Human1.66757656
22AHR_22903824_ChIP-Seq_MCF-7_Human1.64779518
23BCAT_22108803_ChIP-Seq_LS180_Human1.64274608
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63592680
25TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63584825
26ER_23166858_ChIP-Seq_MCF-7_Human1.62725937
27FUS_26573619_Chip-Seq_HEK293_Human1.60739161
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58912297
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57691511
30CBP_20019798_ChIP-Seq_JUKART_Human1.57691511
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57078081
32P300_19829295_ChIP-Seq_ESCs_Human1.56420691
33EWS_26573619_Chip-Seq_HEK293_Human1.56320802
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.55273957
35STAT3_23295773_ChIP-Seq_U87_Human1.55054982
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54506243
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49556799
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49489801
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.47594644
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.46429386
41TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40189084
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.39391172
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38030004
44TCF4_23295773_ChIP-Seq_U87_Human1.37320786
45TCF4_22108803_ChIP-Seq_LS180_Human1.36414449
46ETV1_20927104_ChIP-Seq_GIST48_Human1.35688879
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35265266
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34763532
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32142191
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.32142191
51AR_25329375_ChIP-Seq_VCAP_Human1.26784607
52PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26730992
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.26226568
54PHF8_20622853_ChIP-Seq_HELA_Human1.25862723
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25010441
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25010441
57AR_20517297_ChIP-Seq_VCAP_Human1.24971327
58TP53_18474530_ChIP-ChIP_U2OS_Human1.23929852
59RUNX2_22187159_ChIP-Seq_PCA_Human1.23514593
60SMRT_27268052_Chip-Seq_Bcells_Human1.22302859
61TP63_23658742_ChIP-Seq_EP156T_Human1.21708966
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19992344
63AR_21572438_ChIP-Seq_LNCaP_Human1.19066722
64NCOR_22424771_ChIP-Seq_293T_Human1.18691188
65SOX2_19829295_ChIP-Seq_ESCs_Human1.18480218
66NANOG_19829295_ChIP-Seq_ESCs_Human1.18480218
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.16584231
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16549562
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15198008
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.14028542
71NFYB_21822215_ChIP-Seq_K562_Human1.13844385
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13764790
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13134460
74RBPJ_21746931_ChIP-Seq_IB4_Human1.12476350
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12348504
76NFYA_21822215_ChIP-Seq_K562_Human1.12222840
77* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11587843
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.10186938
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09879628
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09773261
81TBL1_22424771_ChIP-Seq_293T_Human1.09426134
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09290197
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09140105
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.08359131
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07629065
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06950460
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05794064
88CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05581634
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04824025
90CDX2_22108803_ChIP-Seq_LS180_Human1.02984028
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.02447893
92STAT1_20625510_ChIP-Seq_HELA_Human1.01306555
93TP53_22573176_ChIP-Seq_HFKS_Human1.00915718
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00692214
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00190412
96RNF2_27304074_Chip-Seq_NSC_Mouse0.99903246
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99656927
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.99309223
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.98975675
100P53_22387025_ChIP-Seq_ESCs_Mouse0.98533342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.88504707
2MP0008875_abnormal_xenobiotic_pharmacok5.24249570
3MP0001984_abnormal_olfaction3.82714624
4MP0002132_abnormal_respiratory_system3.38158564
5MP0008789_abnormal_olfactory_epithelium3.37600703
6MP0004043_abnormal_pH_regulation3.29283484
7MP0004133_heterotaxia3.21787915
8MP0002277_abnormal_respiratory_mucosa2.96153594
9MP0000383_abnormal_hair_follicle2.52589964
10MP0005499_abnormal_olfactory_system2.26110017
11MP0005394_taste/olfaction_phenotype2.26110017
12MP0002638_abnormal_pupillary_reflex2.21793725
13MP0002160_abnormal_reproductive_system2.18383205
14MP0003136_yellow_coat_color2.11865589
15MP0009780_abnormal_chondrocyte_physiolo2.08381998
16MP0005551_abnormal_eye_electrophysiolog1.95109465
17MP0010678_abnormal_skin_adnexa1.91751802
18MP0003878_abnormal_ear_physiology1.89637666
19MP0005377_hearing/vestibular/ear_phenot1.89637666
20MP0002282_abnormal_trachea_morphology1.83988495
21MP0009046_muscle_twitch1.83570513
22MP0002876_abnormal_thyroid_physiology1.81313767
23MP0005253_abnormal_eye_physiology1.74100645
24MP0000566_synostosis1.72883752
25MP0005646_abnormal_pituitary_gland1.67476328
26MP0002102_abnormal_ear_morphology1.58576878
27MP0003195_calcinosis1.51812125
28MP0002909_abnormal_adrenal_gland1.50771413
29MP0006292_abnormal_olfactory_placode1.47845983
30MP0005389_reproductive_system_phenotype1.43368166
31MP0004019_abnormal_vitamin_homeostasis1.41962823
32MP0008877_abnormal_DNA_methylation1.41340985
33MP0000631_abnormal_neuroendocrine_gland1.37309945
34MP0001485_abnormal_pinna_reflex1.36090692
35MP0002168_other_aberrant_phenotype1.35942926
36MP0005623_abnormal_meninges_morphology1.26341157
37MP0001765_abnormal_ion_homeostasis1.25711865
38MP0008872_abnormal_physiological_respon1.25179175
39MP0002928_abnormal_bile_duct1.24484623
40MP0002735_abnormal_chemical_nociception1.18225194
41MP0002734_abnormal_mechanical_nocicepti1.14713557
42MP0000372_irregular_coat_pigmentation1.14085676
43MP0001968_abnormal_touch/_nociception1.13768588
44MP0006072_abnormal_retinal_apoptosis1.12190814
45MP0001486_abnormal_startle_reflex1.09610916
46MP0002837_dystrophic_cardiac_calcinosis1.08669754
47MP0005395_other_phenotype1.07678792
48MP0003698_abnormal_male_reproductive1.07375861
49MP0004885_abnormal_endolymph1.06773451
50MP0005645_abnormal_hypothalamus_physiol1.05569396
51MP0005636_abnormal_mineral_homeostasis1.05134274
52MP0009745_abnormal_behavioral_response1.04816103
53MP0001324_abnormal_eye_pigmentation1.03426389
54MP0002233_abnormal_nose_morphology1.02889517
55MP0005195_abnormal_posterior_eye0.99384581
56MP0001929_abnormal_gametogenesis0.98866589
57MP0000026_abnormal_inner_ear0.98381595
58MP0005083_abnormal_biliary_tract0.96880050
59MP0002736_abnormal_nociception_after0.96779644
60MP0006276_abnormal_autonomic_nervous0.96336894
61MP0003656_abnormal_erythrocyte_physiolo0.92664457
62MP0001346_abnormal_lacrimal_gland0.91704779
63MP0005085_abnormal_gallbladder_physiolo0.90731475
64MP0002272_abnormal_nervous_system0.89138815
65MP0001970_abnormal_pain_threshold0.87944828
66MP0000427_abnormal_hair_cycle0.86382914
67MP0005248_abnormal_Harderian_gland0.86295457
68MP0002557_abnormal_social/conspecific_i0.86053755
69MP0003718_maternal_effect0.85883665
70MP0003937_abnormal_limbs/digits/tail_de0.83467922
71MP0002572_abnormal_emotion/affect_behav0.82126430
72MP0010386_abnormal_urinary_bladder0.80179029
73MP0005391_vision/eye_phenotype0.78941295
74MP0001963_abnormal_hearing_physiology0.78821315
75MP0000049_abnormal_middle_ear0.78772462
76MP0002229_neurodegeneration0.78251097
77MP0005220_abnormal_exocrine_pancreas0.77120059
78MP0001293_anophthalmia0.76069383
79MP0004147_increased_porphyrin_level0.74414956
80MP0001502_abnormal_circadian_rhythm0.73349576
81MP0003787_abnormal_imprinting0.72392421
82MP0005365_abnormal_bile_salt0.71115803
83MP0004142_abnormal_muscle_tone0.69629766
84MP0002822_catalepsy0.68743475
85MP0003646_muscle_fatigue0.68504358
86MP0002752_abnormal_somatic_nervous0.67288193
87MP0001501_abnormal_sleep_pattern0.67157294
88MP0001529_abnormal_vocalization0.66951232
89MP0003252_abnormal_bile_duct0.66055962
90MP0003938_abnormal_ear_development0.65062846
91MP0001944_abnormal_pancreas_morphology0.63231495
92MP0002938_white_spotting0.62837197
93MP0001270_distended_abdomen0.62552219
94MP0000681_abnormal_thyroid_gland0.62120101
95MP0003880_abnormal_central_pattern0.60160000
96MP0009643_abnormal_urine_homeostasis0.59787479
97MP0001664_abnormal_digestion0.57451077
98MP0005408_hypopigmentation0.56576038
99MP0004215_abnormal_myocardial_fiber0.56474213
100MP0002064_seizures0.55918578

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.96638399
2Rhinitis (HP:0012384)9.18970873
3Chronic bronchitis (HP:0004469)6.92609122
4Bronchiectasis (HP:0002110)6.71074819
5Nasal polyposis (HP:0100582)5.44971520
6Pancreatic fibrosis (HP:0100732)4.43393081
7Abnormality of the nasal mucosa (HP:0000433)4.41816248
8True hermaphroditism (HP:0010459)4.40010391
9Pancreatic cysts (HP:0001737)4.13885295
10Bronchitis (HP:0012387)3.99547690
11Chronic sinusitis (HP:0011109)3.96624368
12Molar tooth sign on MRI (HP:0002419)3.92273628
13Abnormality of midbrain morphology (HP:0002418)3.92273628
14Recurrent sinusitis (HP:0011108)3.90166994
15Infertility (HP:0000789)3.76526782
16Occipital encephalocele (HP:0002085)3.67189846
17Nephronophthisis (HP:0000090)3.63583826
18Cystic liver disease (HP:0006706)3.46391449
19Recurrent otitis media (HP:0000403)3.24430769
20Chronic hepatic failure (HP:0100626)3.17522925
21Male infertility (HP:0003251)3.05808629
22Abnormality of the renal medulla (HP:0100957)2.94555419
23Postaxial foot polydactyly (HP:0001830)2.84898397
24Medial flaring of the eyebrow (HP:0010747)2.83101379
25Chronic otitis media (HP:0000389)2.76746198
26Congenital hepatic fibrosis (HP:0002612)2.57580558
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.51838666
28Anencephaly (HP:0002323)2.48810046
29Tubular atrophy (HP:0000092)2.46804571
30Hyperactive renin-angiotensin system (HP:0000841)2.45432265
31Gait imbalance (HP:0002141)2.40503025
32Congenital primary aphakia (HP:0007707)2.40110887
33Tubulointerstitial nephritis (HP:0001970)2.37117790
34Male pseudohermaphroditism (HP:0000037)2.36154857
35Atelectasis (HP:0100750)2.26096508
36Sclerocornea (HP:0000647)2.20495560
37Decreased circulating renin level (HP:0003351)2.18308503
38Asplenia (HP:0001746)2.15517202
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.15373081
40Furrowed tongue (HP:0000221)2.15264592
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14814393
42Nephrogenic diabetes insipidus (HP:0009806)2.12522588
43Decreased central vision (HP:0007663)2.05345458
44Postaxial hand polydactyly (HP:0001162)2.01855847
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.2615590
46Abnormal respiratory epithelium morphology (HP:0012253)10.4090195
47Abnormal respiratory motile cilium morphology (HP:0005938)10.4090195
48Dynein arm defect of respiratory motile cilia (HP:0012255)10.2335829
49Absent/shortened dynein arms (HP:0200106)10.2335829
50Abnormal respiratory motile cilium physiology (HP:0012261)10.1041923
51Recurrent bronchitis (HP:0002837)1.98067955
52Oculomotor apraxia (HP:0000657)1.94120703
53Abnormality of the renal cortex (HP:0011035)1.92039798
54Polydipsia (HP:0001959)1.84020509
55Abnormal drinking behavior (HP:0030082)1.84020509
56Bile duct proliferation (HP:0001408)1.78562509
57Abnormal biliary tract physiology (HP:0012439)1.78562509
58Abnormal rod and cone electroretinograms (HP:0008323)1.74377575
59Genital tract atresia (HP:0001827)1.73527761
60Vaginal atresia (HP:0000148)1.72796660
61Nephropathy (HP:0000112)1.68218616
62Preaxial hand polydactyly (HP:0001177)1.68013749
63Poor coordination (HP:0002370)1.60352338
64Tubulointerstitial abnormality (HP:0001969)1.59215237
65Abnormality of macular pigmentation (HP:0008002)1.59011777
66Renal salt wasting (HP:0000127)1.57577544
67Hyperaldosteronism (HP:0000859)1.51571251
68Supernumerary spleens (HP:0009799)1.50414345
69Abnormality of renin-angiotensin system (HP:0000847)1.49798941
70Bell-shaped thorax (HP:0001591)1.47750545
71Median cleft lip (HP:0000161)1.46375366
72Absent frontal sinuses (HP:0002688)1.43543742
73Hyperkalemia (HP:0002153)1.42359053
74Retinitis pigmentosa (HP:0000510)1.41421577
75Hypokalemic alkalosis (HP:0001949)1.39558481
76Stage 5 chronic kidney disease (HP:0003774)1.38569715
77Abolished electroretinogram (ERG) (HP:0000550)1.36352629
78Absent speech (HP:0001344)1.29002545
79Polyuria (HP:0000103)1.28136021
80Narrow forehead (HP:0000341)1.27160399
81Aganglionic megacolon (HP:0002251)1.26690314
82Prominent nasal bridge (HP:0000426)1.26000173
83Tubulointerstitial fibrosis (HP:0005576)1.22119815
84Cone-rod dystrophy (HP:0000548)1.21842950
85Multicystic kidney dysplasia (HP:0000003)1.20994830
86Aplasia/Hypoplasia of the lens (HP:0008063)1.20226146
87Abnormality of chloride homeostasis (HP:0011422)1.19311039
88Bony spicule pigmentary retinopathy (HP:0007737)1.19033482
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.14995691
90Specific learning disability (HP:0001328)1.14663044
91Constricted visual fields (HP:0001133)1.14483504
92Congenital stationary night blindness (HP:0007642)1.12993052
93Short thorax (HP:0010306)1.12013940
94Abnormality of renal excretion (HP:0011036)1.11562212
95Holoprosencephaly (HP:0001360)1.06498213
96Broad foot (HP:0001769)1.06212826
97Renal dysplasia (HP:0000110)1.05851057
98Hip dysplasia (HP:0001385)1.05638142
99Central scotoma (HP:0000603)1.05432363
100Optic nerve coloboma (HP:0000588)1.03685614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.56067311
2MST44.70607251
3FRK3.90730130
4MAP4K22.61504436
5EPHA22.54111712
6BCR2.14501178
7ADRBK22.12298872
8NME12.01270368
9PTK2B1.95276052
10TLK11.86961367
11MAP3K41.81497343
12MAPK131.74715761
13GRK11.73560198
14WNK31.70484776
15INSRR1.69032189
16MAPKAPK31.64054022
17BRSK21.63094094
18PINK11.37986018
19BMPR1B1.37881971
20OXSR11.28825106
21ERBB31.22952784
22STK241.14728694
23MAP2K71.10944134
24STK391.06774681
25TXK1.04697571
26TTK1.03942493
27ACVR1B1.03781456
28PNCK1.00055548
29EPHA30.99501905
30WNK40.97127732
31IRAK10.96930537
32MAP3K20.95812847
33STK160.95148242
34STK38L0.94510968
35MAPKAPK50.92683729
36CAMKK20.90345654
37TRPM70.90216362
38ADRBK10.85666241
39EPHA40.82431569
40MAP3K70.80826257
41CASK0.80194470
42NLK0.79803784
43TRIM280.79593370
44FER0.78492402
45ZAK0.76859827
46TAOK30.76116539
47NEK60.74933357
48PAK30.74848658
49PRKCI0.73323681
50PRKCE0.70139529
51WEE10.69411451
52ERBB20.66973681
53NUAK10.66195087
54MUSK0.64687572
55PRKCQ0.62004522
56TIE10.58513218
57DYRK20.55819883
58MARK10.55523196
59CDK190.55440030
60MAP3K120.54698782
61CSK0.52898867
62CCNB10.51088784
63LATS10.51048067
64TNIK0.50526159
65PRKACA0.47559204
66CAMK2A0.47261420
67CAMKK10.47149039
68MKNK20.45877590
69PLK10.45846237
70STK100.45204184
71MAP2K40.43643618
72DYRK1A0.42682259
73HIPK20.41284197
74PRKCG0.41044202
75STK30.41026121
76PLK20.39967207
77CSNK1G20.38690490
78BCKDK0.36284059
79ABL10.34854175
80PRKAA20.34852398
81PKN10.34470498
82STK110.32540183
83PRKCA0.32445854
84TEC0.32101153
85PRKCZ0.31299230
86CHEK20.31231390
87PRKCD0.30532597
88DYRK30.30300505
89CSNK1A1L0.28847970
90CAMK2G0.28477713
91CSNK1A10.28459938
92PASK0.28240982
93SGK10.27656780
94IGF1R0.26755488
95KIT0.26540076
96STK380.26261368
97AURKA0.26174959
98NTRK30.24202225
99MATK0.22699227
100FGFR20.22263642

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.09895951
2Chemical carcinogenesis_Homo sapiens_hsa052043.56650838
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.48864259
4Histidine metabolism_Homo sapiens_hsa003403.42454167
5Phenylalanine metabolism_Homo sapiens_hsa003602.79968780
6Huntingtons disease_Homo sapiens_hsa050162.72187429
7Linoleic acid metabolism_Homo sapiens_hsa005912.64297434
8Caffeine metabolism_Homo sapiens_hsa002322.46918840
9Tyrosine metabolism_Homo sapiens_hsa003502.44596890
10beta-Alanine metabolism_Homo sapiens_hsa004102.41471617
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.27382945
12Retinol metabolism_Homo sapiens_hsa008302.16693141
13Phototransduction_Homo sapiens_hsa047442.10115398
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09821314
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09437653
16ABC transporters_Homo sapiens_hsa020101.89658062
17Glutathione metabolism_Homo sapiens_hsa004801.81585833
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.74215140
19Butanoate metabolism_Homo sapiens_hsa006501.70645565
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68641985
21Nicotine addiction_Homo sapiens_hsa050331.54300061
22Peroxisome_Homo sapiens_hsa041461.53671600
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46766919
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45515152
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43210117
26Olfactory transduction_Homo sapiens_hsa047401.42311887
27Arachidonic acid metabolism_Homo sapiens_hsa005901.36827101
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36512041
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30665515
30Tryptophan metabolism_Homo sapiens_hsa003801.29729906
31Taste transduction_Homo sapiens_hsa047421.28891094
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28181149
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25127359
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24208010
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.22576605
36Nitrogen metabolism_Homo sapiens_hsa009101.19396589
37Sphingolipid metabolism_Homo sapiens_hsa006001.18811260
38Salivary secretion_Homo sapiens_hsa049701.15588068
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.10949915
40Fatty acid degradation_Homo sapiens_hsa000711.08852541
41Circadian rhythm_Homo sapiens_hsa047101.04734769
42Protein export_Homo sapiens_hsa030601.00072951
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92629048
44Oxidative phosphorylation_Homo sapiens_hsa001900.91475623
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86689900
46Ether lipid metabolism_Homo sapiens_hsa005650.84358682
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81890398
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78451594
49Propanoate metabolism_Homo sapiens_hsa006400.76034401
50Serotonergic synapse_Homo sapiens_hsa047260.75102008
51Collecting duct acid secretion_Homo sapiens_hsa049660.74660143
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.74310276
53Starch and sucrose metabolism_Homo sapiens_hsa005000.72135843
54Hedgehog signaling pathway_Homo sapiens_hsa043400.71920305
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69528530
56Glycerolipid metabolism_Homo sapiens_hsa005610.64962684
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63862561
58Metabolic pathways_Homo sapiens_hsa011000.60798986
59Regulation of autophagy_Homo sapiens_hsa041400.60473088
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59365630
61Cardiac muscle contraction_Homo sapiens_hsa042600.58570152
62Tight junction_Homo sapiens_hsa045300.58057423
63Asthma_Homo sapiens_hsa053100.55579227
64Type I diabetes mellitus_Homo sapiens_hsa049400.53954558
65Basal cell carcinoma_Homo sapiens_hsa052170.53753329
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53061919
67Calcium signaling pathway_Homo sapiens_hsa040200.52161824
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.51656809
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.51439749
70Steroid biosynthesis_Homo sapiens_hsa001000.50914859
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48285653
72Parkinsons disease_Homo sapiens_hsa050120.47620770
73Basal transcription factors_Homo sapiens_hsa030220.46182180
74Ovarian steroidogenesis_Homo sapiens_hsa049130.45861812
75Cocaine addiction_Homo sapiens_hsa050300.43521176
76Morphine addiction_Homo sapiens_hsa050320.43112113
77Vitamin digestion and absorption_Homo sapiens_hsa049770.41440159
78Hematopoietic cell lineage_Homo sapiens_hsa046400.40406389
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40088820
80Selenocompound metabolism_Homo sapiens_hsa004500.38848259
81Alzheimers disease_Homo sapiens_hsa050100.38161214
82Glutamatergic synapse_Homo sapiens_hsa047240.38085386
83cAMP signaling pathway_Homo sapiens_hsa040240.36829070
84Circadian entrainment_Homo sapiens_hsa047130.36476724
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35554849
86Purine metabolism_Homo sapiens_hsa002300.35222288
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34620951
88Insulin secretion_Homo sapiens_hsa049110.34414186
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33842946
90Arginine and proline metabolism_Homo sapiens_hsa003300.33323612
91Allograft rejection_Homo sapiens_hsa053300.33310922
92Fanconi anemia pathway_Homo sapiens_hsa034600.32585420
93Mineral absorption_Homo sapiens_hsa049780.30821286
94Amphetamine addiction_Homo sapiens_hsa050310.29653354
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26739942
96Homologous recombination_Homo sapiens_hsa034400.26158428
97GABAergic synapse_Homo sapiens_hsa047270.25370709
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25204274
99Graft-versus-host disease_Homo sapiens_hsa053320.24330890
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23142718

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