TSPAN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.77954216
2* axon ensheathment (GO:0008366)7.08041022
3* ensheathment of neurons (GO:0007272)7.08041022
4* myelination (GO:0042552)7.00612005
5long-chain fatty acid biosynthetic process (GO:0042759)6.02242967
6negative regulation of neurotransmitter secretion (GO:0046929)5.77942842
7neutrophil activation involved in immune response (GO:0002283)5.77588395
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.31125321
9myelin maintenance (GO:0043217)5.11438744
10negative regulation of neurotransmitter transport (GO:0051589)4.93385072
11apical protein localization (GO:0045176)4.75272792
12cholesterol biosynthetic process (GO:0006695)4.70829932
13asymmetric protein localization (GO:0008105)4.63841582
14glycerophospholipid catabolic process (GO:0046475)4.60536778
15creatine metabolic process (GO:0006600)4.46920667
16neutrophil activation (GO:0042119)4.44296700
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41372607
18negative regulation of cell killing (GO:0031342)4.41372607
19adhesion of symbiont to host cell (GO:0044650)4.34729196
20virion attachment to host cell (GO:0019062)4.34729196
21presynaptic membrane organization (GO:0097090)4.34330435
22eye photoreceptor cell differentiation (GO:0001754)4.30804327
23photoreceptor cell differentiation (GO:0046530)4.30804327
24establishment of mitochondrion localization (GO:0051654)4.29468607
25presynaptic membrane assembly (GO:0097105)4.25150012
26regulation of collateral sprouting (GO:0048670)4.23051551
27negative regulation of protein localization to cell surface (GO:2000009)4.14873129
28substantia nigra development (GO:0021762)4.11791240
29sterol biosynthetic process (GO:0016126)4.10155269
30microglial cell activation (GO:0001774)4.09366771
31peptidyl-tyrosine autophosphorylation (GO:0038083)4.07849270
32positive regulation of oligodendrocyte differentiation (GO:0048714)3.93833426
33long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.88972075
34response to redox state (GO:0051775)3.83827073
35negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.82477635
36* oligodendrocyte differentiation (GO:0048709)3.81414614
37import into cell (GO:0098657)3.73115706
38L-amino acid import (GO:0043092)3.72865722
39regulation of type B pancreatic cell apoptotic process (GO:2000674)3.70210742
40cellular extravasation (GO:0045123)3.69431736
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66519194
42positive regulation of action potential (GO:0045760)3.65782177
43isoprenoid biosynthetic process (GO:0008299)3.64737633
44positive regulation of gamma-delta T cell activation (GO:0046645)3.62730738
45myelination in peripheral nervous system (GO:0022011)3.62259474
46peripheral nervous system axon ensheathment (GO:0032292)3.62259474
47granulocyte activation (GO:0036230)3.59613161
48thrombin receptor signaling pathway (GO:0070493)3.58760151
49amyloid precursor protein metabolic process (GO:0042982)3.55059321
50protein palmitoylation (GO:0018345)3.54247894
51regulation of memory T cell differentiation (GO:0043380)3.53479987
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.52527153
53aggressive behavior (GO:0002118)3.48699096
54negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.45346785
55negative regulation of T-helper cell differentiation (GO:0045623)3.45346785
56protein neddylation (GO:0045116)3.45279582
57response to lipoprotein particle (GO:0055094)3.42212695
58response to methylmercury (GO:0051597)3.40839039
59positive regulation by symbiont of host defense response (GO:0052509)3.38883614
60modulation by symbiont of host defense response (GO:0052031)3.38883614
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38883614
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38883614
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.38883614
64modulation by symbiont of host immune response (GO:0052553)3.38883614
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37650572
66transmission of nerve impulse (GO:0019226)3.36406094
67fatty-acyl-CoA biosynthetic process (GO:0046949)3.36191575
68inositol phosphate catabolic process (GO:0071545)3.32793210
69regulation of platelet aggregation (GO:0090330)3.31120333
70magnesium ion transport (GO:0015693)3.30140599
71negative regulation of axonogenesis (GO:0050771)3.27748409
72regulation of regulatory T cell differentiation (GO:0045589)3.27454417
73nitric oxide mediated signal transduction (GO:0007263)3.27047383
74adult walking behavior (GO:0007628)3.26229846
75cerebral cortex radially oriented cell migration (GO:0021799)3.26166657
76glycosylceramide metabolic process (GO:0006677)3.26030337
77detection of other organism (GO:0098543)3.25320213
78GPI anchor biosynthetic process (GO:0006506)3.24796295
79antigen processing and presentation of endogenous antigen (GO:0019883)3.23473360
80negative regulation of lymphocyte mediated immunity (GO:0002707)3.20381040
81adhesion of symbiont to host (GO:0044406)3.19931827
82membrane tubulation (GO:0097320)3.19652098
83macrophage activation (GO:0042116)3.19580478
84neutrophil mediated immunity (GO:0002446)3.19391340
85GPI anchor metabolic process (GO:0006505)3.19307735
86negative regulation of JUN kinase activity (GO:0043508)3.17779916
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16943106
88regulation of B cell receptor signaling pathway (GO:0050855)3.16532968
89leukocyte migration involved in inflammatory response (GO:0002523)3.16181541
90inositol phosphate dephosphorylation (GO:0046855)3.14839422
91phosphorylated carbohydrate dephosphorylation (GO:0046838)3.14839422
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14312608
93response to host immune response (GO:0052572)3.14312608
94negative regulation of glycoprotein biosynthetic process (GO:0010561)3.12837717
95limb bud formation (GO:0060174)3.12799119
96adaptation of signaling pathway (GO:0023058)3.12480766
97fatty-acyl-CoA metabolic process (GO:0035337)3.10999472
98cellular response to epinephrine stimulus (GO:0071872)3.10542035
99neuron cell-cell adhesion (GO:0007158)3.10019075
100negative regulation of protein oligomerization (GO:0032460)3.09267701
101leukocyte aggregation (GO:0070486)3.08677437
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07047067
103nucleotide transmembrane transport (GO:1901679)3.04975337
104response to peptidoglycan (GO:0032494)3.00858893
105positive regulation of mast cell activation (GO:0033005)2.98838661
106respiratory burst (GO:0045730)2.98571080
107peptidyl-cysteine modification (GO:0018198)2.96069733
108preassembly of GPI anchor in ER membrane (GO:0016254)2.95637708
109detection of bacterium (GO:0016045)2.92678956
110positive regulation of granulocyte differentiation (GO:0030854)2.92287952
111negative regulation of phagocytosis (GO:0050765)2.91278878
112production of molecular mediator involved in inflammatory response (GO:0002532)2.89434652
113nerve growth factor signaling pathway (GO:0038180)2.87770195
114neuronal ion channel clustering (GO:0045161)2.86930862
115neuron remodeling (GO:0016322)2.86434931
116peripheral nervous system development (GO:0007422)2.86150240
117positive regulation of cellular amine metabolic process (GO:0033240)2.84600108
118macrophage activation involved in immune response (GO:0002281)2.81605026
119positive regulation of glial cell differentiation (GO:0045687)2.81110243
120regulation of platelet activation (GO:0010543)2.80665107
121detection of molecule of bacterial origin (GO:0032490)2.80168040
122insulin secretion (GO:0030073)2.79191548
123neural nucleus development (GO:0048857)2.78332845
124very long-chain fatty acid metabolic process (GO:0000038)2.77893859
125leukocyte degranulation (GO:0043299)2.77738217
126interleukin-6-mediated signaling pathway (GO:0070102)2.77540028
127membrane assembly (GO:0071709)2.76893608
128negative regulation of alpha-beta T cell differentiation (GO:0046639)2.75843968
129detection of external biotic stimulus (GO:0098581)2.75454309
130response to epinephrine (GO:0071871)2.75096279
131neuronal action potential propagation (GO:0019227)2.74521765
132amyloid precursor protein catabolic process (GO:0042987)2.74328913
133negative regulation of axon extension (GO:0030517)2.74287840
134regulation of B cell apoptotic process (GO:0002902)2.71898024
135organ growth (GO:0035265)2.71777675
136Leydig cell differentiation (GO:0033327)2.70500077
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.70306239
138amino acid import (GO:0043090)2.69073611
139histamine secretion (GO:0001821)2.68814465
140ear development (GO:0043583)2.68511306
141endocrine pancreas development (GO:0031018)2.67991249
142negative regulation of execution phase of apoptosis (GO:1900118)2.67324798
143acyl-CoA biosynthetic process (GO:0071616)2.67271114
144thioester biosynthetic process (GO:0035384)2.67271114
145cerebellar granule cell differentiation (GO:0021707)2.67065642
146myeloid cell activation involved in immune response (GO:0002275)2.65431710
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64910826
148response to host (GO:0075136)2.64910826
149response to host defenses (GO:0052200)2.64910826
150positive regulation of B cell differentiation (GO:0045579)2.63954250
151G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63716969
152regulation of lipoprotein metabolic process (GO:0050746)2.63154556
153relaxation of smooth muscle (GO:0044557)2.62209957
154purinergic nucleotide receptor signaling pathway (GO:0035590)2.61975757
155Golgi to plasma membrane protein transport (GO:0043001)2.61458034
156antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61152625
157polyol catabolic process (GO:0046174)2.60944902
158regulation of gamma-delta T cell activation (GO:0046643)2.58991492
159activated T cell proliferation (GO:0050798)2.58913287
160positive regulation of gliogenesis (GO:0014015)2.57966570
161phagosome maturation (GO:0090382)2.56681555
162histone H2B ubiquitination (GO:0033523)2.56376194
163monoamine transport (GO:0015844)2.56328176
164dopamine transport (GO:0015872)2.56263640
165protein localization to endosome (GO:0036010)2.55507462
166neurotransmitter catabolic process (GO:0042135)2.55001952
167cellular response to catecholamine stimulus (GO:0071870)2.54895999
168cellular response to monoamine stimulus (GO:0071868)2.54895999
169positive regulation of toll-like receptor signaling pathway (GO:0034123)2.53764090
170glucosamine-containing compound catabolic process (GO:1901072)2.53394835
171enteric nervous system development (GO:0048484)2.53299014
172regulation of gamma-delta T cell differentiation (GO:0045586)2.52861232
173response to hepatocyte growth factor (GO:0035728)2.51781600
174cellular response to hepatocyte growth factor stimulus (GO:0035729)2.51781600
175regulation of dopamine metabolic process (GO:0042053)2.51375002
176regulation of catecholamine metabolic process (GO:0042069)2.51375002
177regulation of interferon-beta biosynthetic process (GO:0045357)2.51312648
178L-serine transport (GO:0015825)2.50783163
179microtubule polymerization or depolymerization (GO:0031109)2.50701993
180negative regulation of B cell mediated immunity (GO:0002713)2.49155785
181negative regulation of immunoglobulin mediated immune response (GO:0002890)2.49155785
182platelet dense granule organization (GO:0060155)2.48969194
183regulation of B cell differentiation (GO:0045577)2.48537209
184maternal behavior (GO:0042711)2.47481761
185myeloid leukocyte mediated immunity (GO:0002444)2.46420280
186xenobiotic catabolic process (GO:0042178)2.45617111
187parental behavior (GO:0060746)2.45224270
188definitive hemopoiesis (GO:0060216)2.44287848
189regulation of hexokinase activity (GO:1903299)2.43514438
190regulation of glucokinase activity (GO:0033131)2.43514438
191regulation of mast cell activation (GO:0033003)2.43192247
192superoxide anion generation (GO:0042554)2.42913592
193negative regulation of thymocyte apoptotic process (GO:0070244)2.42639967
194negative regulation of leukocyte mediated immunity (GO:0002704)2.41537400
195megakaryocyte development (GO:0035855)2.41441158
196response to interleukin-15 (GO:0070672)2.40652433
197axon ensheathment in central nervous system (GO:0032291)11.5966810
198central nervous system myelination (GO:0022010)11.5966810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.29693145
2GBX2_23144817_ChIP-Seq_PC3_Human3.50323596
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85720625
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.73320498
5* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.73071063
6TAF15_26573619_Chip-Seq_HEK293_Human2.65440107
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.59832390
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.47984691
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.37925890
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32036319
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28629140
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27761043
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20046115
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.14122189
15OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12426881
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11705911
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.07340788
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04057285
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00553338
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00553338
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93557687
22EZH2_22144423_ChIP-Seq_EOC_Human1.91650801
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90182896
24SCL_19346495_ChIP-Seq_HPC-7_Human1.89071237
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87475062
26IGF1R_20145208_ChIP-Seq_DFB_Human1.87430740
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87398023
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.85003514
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.84954243
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84399072
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83722412
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81926594
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79354087
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.76884190
35VDR_22108803_ChIP-Seq_LS180_Human1.76538476
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74854087
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72968148
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72459993
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.70835702
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70483520
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70171664
42* ER_23166858_ChIP-Seq_MCF-7_Human1.69008080
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.68532252
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68303845
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66115517
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65630517
47* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65432190
48DROSHA_22980978_ChIP-Seq_HELA_Human1.64024945
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63792809
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63244293
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.59418874
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58674338
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.58263943
54AR_21572438_ChIP-Seq_LNCaP_Human1.57723063
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.56396686
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53107078
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.51592114
58ZNF274_21170338_ChIP-Seq_K562_Hela1.51090998
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.51086958
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50543641
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50210195
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50010800
63SPI1_23127762_ChIP-Seq_K562_Human1.48098331
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45007060
65* RUNX_20019798_ChIP-Seq_JUKART_Human1.43053892
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42491371
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40655216
68BCAT_22108803_ChIP-Seq_LS180_Human1.39696650
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.38561255
70FUS_26573619_Chip-Seq_HEK293_Human1.37005657
71SPI1_23547873_ChIP-Seq_NB4_Human1.35562202
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.35539011
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33387489
74GATA3_26560356_Chip-Seq_TH2_Human1.33089604
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30583869
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29180132
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29048225
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28805942
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.27485913
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.27210166
81GATA3_27048872_Chip-Seq_THYMUS_Human1.27181161
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26676681
83P300_19829295_ChIP-Seq_ESCs_Human1.26608420
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24581855
85* MYB_26560356_Chip-Seq_TH2_Human1.24262201
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24194466
87* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23283434
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22104323
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22067294
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18909204
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.18154604
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18112146
93EWS_26573619_Chip-Seq_HEK293_Human1.17584657
94AR_25329375_ChIP-Seq_VCAP_Human1.17475932
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.17434009
96P53_22387025_ChIP-Seq_ESCs_Mouse1.16674543
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15951108
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15687481
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15204942
100STAT3_23295773_ChIP-Seq_U87_Human1.14821611
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14742294
102SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13819730
103REST_21632747_ChIP-Seq_MESCs_Mouse1.12482167
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12086915
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.10931235
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10777238
107VDR_24787735_ChIP-Seq_THP-1_Human1.09110164
108LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09042888
109EOMES_21245162_ChIP-Seq_HESCs_Human1.08888796
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.08751668
111RNF2_27304074_Chip-Seq_NSC_Mouse1.08293706
112* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07970361
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07970361
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.06070319
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.05872453
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.04432805
117GATA2_19941826_ChIP-Seq_K562_Human1.03553326
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02993744
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.02865256
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02851282
121TCF4_23295773_ChIP-Seq_U87_Human1.02214934
122SMRT_27268052_Chip-Seq_Bcells_Human1.01945194
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00862399
124* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00234047
125* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00171582
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00117875
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99958480
128* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99821635
129HTT_18923047_ChIP-ChIP_STHdh_Human0.99817905
130TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99215866
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98736712
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98210501
133SMAD4_21799915_ChIP-Seq_A2780_Human0.97989452
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97533458
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97158550
136* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97077586
137BP1_19119308_ChIP-ChIP_Hs578T_Human0.97076095
138FOXA1_25329375_ChIP-Seq_VCAP_Human0.97027966
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97027966
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.96525892
141AR_20517297_ChIP-Seq_VCAP_Human0.96282000
142CDX2_22108803_ChIP-Seq_LS180_Human0.95917372
143* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95585214
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95263850
145* P300_18555785_Chip-Seq_ESCs_Mouse0.94438464
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93922726
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93619903
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.93537294
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.93107189
150* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92859732
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91824052
152AHR_22903824_ChIP-Seq_MCF-7_Human0.91003399
153FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90661406
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89283665
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.89113447
156EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88206210
157RING1B_27294783_Chip-Seq_NPCs_Mouse0.88193365
158* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87800261
159NANOG_19829295_ChIP-Seq_ESCs_Human0.87662848
160SOX2_19829295_ChIP-Seq_ESCs_Human0.87662848
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87401235
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86991733
163* TBL1_22424771_ChIP-Seq_293T_Human0.86507470
164* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86006386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.80211902
2MP0003724_increased_susceptibility_to4.75986564
3MP0005464_abnormal_platelet_physiology4.24892155
4MP0003880_abnormal_central_pattern3.97173972
5MP0003787_abnormal_imprinting3.61561732
6MP0003950_abnormal_plasma_membrane3.58586001
7MP0004270_analgesia3.55209719
8MP0003690_abnormal_glial_cell3.27441983
9MP0004885_abnormal_endolymph2.97440385
10MP0002837_dystrophic_cardiac_calcinosis2.88790938
11MP0001529_abnormal_vocalization2.74939968
12MP0003329_amyloid_beta_deposits2.71344564
13MP0004742_abnormal_vestibular_system2.64883697
14MP0001905_abnormal_dopamine_level2.53673969
15MP0002272_abnormal_nervous_system2.52494406
16MP0002132_abnormal_respiratory_system2.49052204
17MP0001486_abnormal_startle_reflex2.47205335
18MP0003634_abnormal_glial_cell2.46472034
19MP0003136_yellow_coat_color2.46388376
20MP0005171_absent_coat_pigmentation2.41758667
21MP0001485_abnormal_pinna_reflex2.40703023
22MP0001835_abnormal_antigen_presentation2.33928752
23MP0005084_abnormal_gallbladder_morpholo2.31718975
24MP0005409_darkened_coat_color2.22990986
25MP0008877_abnormal_DNA_methylation2.20910134
26MP0003283_abnormal_digestive_organ2.18147638
27MP0002064_seizures2.18146300
28MP0004142_abnormal_muscle_tone2.17473703
29MP0000778_abnormal_nervous_system2.15316417
30MP0004859_abnormal_synaptic_plasticity2.10026769
31MP0005451_abnormal_body_composition2.06825854
32MP0002693_abnormal_pancreas_physiology2.06160334
33MP0002909_abnormal_adrenal_gland2.02297992
34MP0005645_abnormal_hypothalamus_physiol1.98545005
35MP0002229_neurodegeneration1.96050978
36MP0003122_maternal_imprinting1.93287766
37MP0000462_abnormal_digestive_system1.89048114
38MP0009046_muscle_twitch1.88325372
39MP0003632_abnormal_nervous_system1.86924154
40MP0000465_gastrointestinal_hemorrhage1.85447413
41MP0003436_decreased_susceptibility_to1.84959720
42MP0002277_abnormal_respiratory_mucosa1.84344218
43MP0005379_endocrine/exocrine_gland_phen1.82956676
44MP0008004_abnormal_stomach_pH1.82850517
45MP0000013_abnormal_adipose_tissue1.82783898
46MP0005410_abnormal_fertilization1.77566573
47MP0003172_abnormal_lysosome_physiology1.74883181
48MP0002734_abnormal_mechanical_nocicepti1.74495453
49MP0002419_abnormal_innate_immunity1.71034276
50MP0010678_abnormal_skin_adnexa1.68839198
51MP0003303_peritoneal_inflammation1.68409651
52MP0009745_abnormal_behavioral_response1.68395160
53MP0004147_increased_porphyrin_level1.68030402
54MP0003635_abnormal_synaptic_transmissio1.67921157
55MP0010386_abnormal_urinary_bladder1.61977872
56MP0003011_delayed_dark_adaptation1.61491387
57MP0000383_abnormal_hair_follicle1.60323236
58MP0005646_abnormal_pituitary_gland1.57654365
59MP0004484_altered_response_of1.57253735
60MP0009785_altered_susceptibility_to1.54692893
61MP0005423_abnormal_somatic_nervous1.54189347
62MP0004381_abnormal_hair_follicle1.54110484
63MP0002102_abnormal_ear_morphology1.50540479
64MP0001944_abnormal_pancreas_morphology1.49884793
65MP0004043_abnormal_pH_regulation1.47713248
66MP0000955_abnormal_spinal_cord1.47289010
67MP0005000_abnormal_immune_tolerance1.45200935
68MP0002163_abnormal_gland_morphology1.44956716
69MP0005671_abnormal_response_to1.41061297
70MP0002254_reproductive_system_inflammat1.41002948
71MP0002882_abnormal_neuron_morphology1.39966820
72MP0005551_abnormal_eye_electrophysiolog1.39766169
73MP0001545_abnormal_hematopoietic_system1.38165934
74MP0005397_hematopoietic_system_phenotyp1.38165934
75MP0005025_abnormal_response_to1.37976404
76MP0001533_abnormal_skeleton_physiology1.36928332
77MP0001440_abnormal_grooming_behavior1.36888281
78MP0002723_abnormal_immune_serum1.36822672
79MP0005075_abnormal_melanosome_morpholog1.36346659
80MP0002420_abnormal_adaptive_immunity1.35866149
81MP0000685_abnormal_immune_system1.35697114
82MP0000604_amyloidosis1.35199481
83MP0001819_abnormal_immune_cell1.34649040
84MP0001963_abnormal_hearing_physiology1.30024128
85MP0003631_nervous_system_phenotype1.29512657
86MP0001661_extended_life_span1.29228100
87MP0001800_abnormal_humoral_immune1.28670175
88MP0005248_abnormal_Harderian_gland1.27990536
89MP0004134_abnormal_chest_morphology1.26739084
90MP0001299_abnormal_eye_distance/1.26248354
91MP0002066_abnormal_motor_capabilities/c1.25301449
92MP0005220_abnormal_exocrine_pancreas1.24900797
93MP0002572_abnormal_emotion/affect_behav1.24847797
94MP0000230_abnormal_systemic_arterial1.24769362
95MP0003300_gastrointestinal_ulcer1.23479155
96MP0001346_abnormal_lacrimal_gland1.23344593
97MP0001845_abnormal_inflammatory_respons1.23035751
98MP0005174_abnormal_tail_pigmentation1.22616064
99MP0004924_abnormal_behavior1.21682660
100MP0005386_behavior/neurological_phenoty1.21682660
101MP0003866_abnormal_defecation1.21591136
102MP0000747_muscle_weakness1.21154192
103MP0003806_abnormal_nucleotide_metabolis1.20868459
104MP0003121_genomic_imprinting1.20540411
105MP0002452_abnormal_antigen_presenting1.20489330
106MP0008260_abnormal_autophagy1.19832573
107MP0002928_abnormal_bile_duct1.19698032
108MP0002752_abnormal_somatic_nervous1.18859770
109MP0002067_abnormal_sensory_capabilities1.15735802
110MP0008569_lethality_at_weaning1.15628088
111MP0005623_abnormal_meninges_morphology1.15561677
112MP0002148_abnormal_hypersensitivity_rea1.13393136
113MP0000566_synostosis1.12590979
114MP0002063_abnormal_learning/memory/cond1.12549298
115MP0001970_abnormal_pain_threshold1.12336001
116MP0000689_abnormal_spleen_morphology1.12305493
117MP0002398_abnormal_bone_marrow1.09846934
118MP0000516_abnormal_urinary_system1.09789754
119MP0005367_renal/urinary_system_phenotyp1.09789754
120MP0008872_abnormal_physiological_respon1.08640773
121MP0002078_abnormal_glucose_homeostasis1.08458641
122MP0001790_abnormal_immune_system1.06907165
123MP0005387_immune_system_phenotype1.06907165
124MP0003075_altered_response_to1.03915493
125MP0002166_altered_tumor_susceptibility1.03114285
126MP0001851_eye_inflammation1.03079048
127MP0003633_abnormal_nervous_system1.02875570
128MP0005535_abnormal_body_temperature1.02391214
129MP0001765_abnormal_ion_homeostasis1.02116782
130MP0000716_abnormal_immune_system1.01126284
131MP0000015_abnormal_ear_pigmentation1.00697684
132MP0003938_abnormal_ear_development1.00082174
133MP0002733_abnormal_thermal_nociception0.98388922
134MP0001756_abnormal_urination0.97224475
135MP0005195_abnormal_posterior_eye0.96380862
136MP0003656_abnormal_erythrocyte_physiolo0.96204849
137MP0001986_abnormal_taste_sensitivity0.96065158
138MP0003937_abnormal_limbs/digits/tail_de0.95255002
139MP0002722_abnormal_immune_system0.95044527
140MP0001348_abnormal_lacrimal_gland0.94817264
141MP0002405_respiratory_system_inflammati0.93841495
142MP0005058_abnormal_lysosome_morphology0.93411476
143MP0003195_calcinosis0.92959065
144MP0000647_abnormal_sebaceous_gland0.92714105
145MP0004145_abnormal_muscle_electrophysio0.92493777
146MP0001984_abnormal_olfaction0.92303747
147MP0005408_hypopigmentation0.91593905
148MP0000026_abnormal_inner_ear0.86443244
149MP0004883_abnormal_blood_vessel0.84211578
150MP0000762_abnormal_tongue_morphology0.83450415
151MP0002152_abnormal_brain_morphology0.83411774
152MP0010155_abnormal_intestine_physiology0.83031188
153MP0000703_abnormal_thymus_morphology0.82748625
154MP0002429_abnormal_blood_cell0.82729251
155MP0002295_abnormal_pulmonary_circulatio0.82726480
156MP0010329_abnormal_lipoprotein_level0.82679635
157MP0006072_abnormal_retinal_apoptosis0.81710802
158MP0004510_myositis0.81701681
159MP0001177_atelectasis0.81449668
160MP0002735_abnormal_chemical_nociception0.80266141
161MP0008469_abnormal_protein_level0.80032544
162MP0006036_abnormal_mitochondrial_physio0.79421084
163MP0009642_abnormal_blood_homeostasis0.79386110
164MP0001727_abnormal_embryo_implantation0.79236297
165MP0003828_pulmonary_edema0.78025108
166MP0000467_abnormal_esophagus_morphology0.76127558
167MP0009764_decreased_sensitivity_to0.75587070
168MP0005636_abnormal_mineral_homeostasis0.73468279
169MP0009780_abnormal_chondrocyte_physiolo0.73252734
170MP0001968_abnormal_touch/_nociception0.73108285
171MP0008438_abnormal_cutaneous_collagen0.72090814
172MP0003943_abnormal_hepatobiliary_system0.71094083
173MP0005253_abnormal_eye_physiology0.70304097
174MP0003191_abnormal_cellular_cholesterol0.69977508
175MP0004808_abnormal_hematopoietic_stem0.69508048
176MP0004185_abnormal_adipocyte_glucose0.68784638
177MP0004036_abnormal_muscle_relaxation0.68673595
178MP0003137_abnormal_impulse_conducting0.66543937
179MP0004133_heterotaxia0.66353373
180MP0002184_abnormal_innervation0.65819735
181MP0001501_abnormal_sleep_pattern0.65652724
182MP0001502_abnormal_circadian_rhythm0.62854054
183MP0006082_CNS_inflammation0.61624188
184MP0002090_abnormal_vision0.60872121
185MP0002736_abnormal_nociception_after0.59662239
186MP0005388_respiratory_system_phenotype0.58459397
187MP0002133_abnormal_respiratory_system0.58459397
188MP0000579_abnormal_nail_morphology0.57506989
189MP0002557_abnormal_social/conspecific_i0.55180479
190MP0001340_abnormal_eyelid_morphology0.54617403

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.84400761
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.84400761
3Neurofibrillary tangles (HP:0002185)6.32331806
4Prolonged bleeding time (HP:0003010)6.14429437
5Sensory axonal neuropathy (HP:0003390)5.50623768
6Petechiae (HP:0000967)5.07914834
7Parakeratosis (HP:0001036)5.06229012
8Abnormality of the corticospinal tract (HP:0002492)5.04053231
9Stomatitis (HP:0010280)4.96353235
10Cerebral inclusion bodies (HP:0100314)4.48205170
11Peripheral hypomyelination (HP:0007182)4.44829445
12Gingival bleeding (HP:0000225)4.17316944
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.92612766
14Menorrhagia (HP:0000132)3.81969638
15Cerebral hypomyelination (HP:0006808)3.78595451
16Spastic gait (HP:0002064)3.77601804
17Abnormal platelet volume (HP:0011876)3.76520004
18Epistaxis (HP:0000421)3.74762539
19Supranuclear gaze palsy (HP:0000605)3.71387496
20Onion bulb formation (HP:0003383)3.63341846
21Increased mean platelet volume (HP:0011877)3.52945421
22Myositis (HP:0100614)3.49768048
23Recurrent abscess formation (HP:0002722)3.49755228
24Intention tremor (HP:0002080)3.36189756
25Akinesia (HP:0002304)3.34990663
26Recurrent bacterial skin infections (HP:0005406)3.34775610
27Hypoglycemic coma (HP:0001325)3.31200629
28Alacrima (HP:0000522)3.31147834
29Elevated erythrocyte sedimentation rate (HP:0003565)3.31128032
30Abnormal auditory evoked potentials (HP:0006958)3.29876471
31Eczematoid dermatitis (HP:0000976)3.27969950
32Hypoglycemic seizures (HP:0002173)3.25913660
33Dysmetria (HP:0001310)3.19878403
34Episodic fever (HP:0001954)3.19229593
35Optic neuritis (HP:0100653)3.16301344
36Retrobulbar optic neuritis (HP:0100654)3.16301344
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.13023458
38Termporal pattern (HP:0011008)3.07832513
39Insidious onset (HP:0003587)3.07832513
40Abnormal pupillary function (HP:0007686)3.06283450
41Abnormality of macrophages (HP:0004311)3.06099821
42Orchitis (HP:0100796)3.05924387
43Purpura (HP:0000979)3.05497103
44Hypochromic microcytic anemia (HP:0004840)2.95723890
45Thickened helices (HP:0000391)2.91299497
46Spontaneous hematomas (HP:0007420)2.88433800
47Hyperinsulinemic hypoglycemia (HP:0000825)2.88247191
48Encephalitis (HP:0002383)2.87018904
49Leukodystrophy (HP:0002415)2.86285427
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.85644135
51Increased serum pyruvate (HP:0003542)2.83798600
52Abnormality of glycolysis (HP:0004366)2.83798600
53Scanning speech (HP:0002168)2.82272311
54Slow saccadic eye movements (HP:0000514)2.81830393
55Autoamputation (HP:0001218)2.80946601
56Myokymia (HP:0002411)2.80490739
57Hyperlipoproteinemia (HP:0010980)2.80314706
58Congenital ichthyosiform erythroderma (HP:0007431)2.78340693
59Hematochezia (HP:0002573)2.76225659
60Hyperglycemia (HP:0003074)2.75696895
61Anteriorly placed anus (HP:0001545)2.73768039
62Spastic paraparesis (HP:0002313)2.73321267
63Hypothermia (HP:0002045)2.72419517
64Ketoacidosis (HP:0001993)2.71422962
65Retinal dysplasia (HP:0007973)2.70285808
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69647364
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.68153134
68Premature skin wrinkling (HP:0100678)2.65858648
69Hypoplastic pelvis (HP:0008839)2.62943646
70Ankle clonus (HP:0011448)2.61935939
71Panhypogammaglobulinemia (HP:0003139)2.58678993
72Decreased lacrimation (HP:0000633)2.57888603
73Stridor (HP:0010307)2.57323743
74Abnormality of the pancreatic islet cells (HP:0006476)2.56593909
75Abnormality of endocrine pancreas physiology (HP:0012093)2.56593909
76Cerebral hemorrhage (HP:0001342)2.55595551
77Absent septum pellucidum (HP:0001331)2.51842269
78Recurrent fungal infections (HP:0002841)2.47025274
79Recurrent cutaneous fungal infections (HP:0011370)2.43800534
80Chronic mucocutaneous candidiasis (HP:0002728)2.43800534
81Increased circulating renin level (HP:0000848)2.40133538
82Split foot (HP:0001839)2.35066012
83CNS hypomyelination (HP:0003429)2.34100636
84Clumsiness (HP:0002312)2.34076152
85Recurrent skin infections (HP:0001581)2.31962548
86Coronal craniosynostosis (HP:0004440)2.28023127
87Arterial thrombosis (HP:0004420)2.24808186
88Pancreatic islet-cell hyperplasia (HP:0004510)2.23604820
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.22051889
90Pheochromocytoma (HP:0002666)2.20812727
91Infantile muscular hypotonia (HP:0008947)2.20549768
92Morphological abnormality of the inner ear (HP:0011390)2.19351727
93Hypomagnesemia (HP:0002917)2.18638108
94Chronic obstructive pulmonary disease (HP:0006510)2.17431724
95Obstructive lung disease (HP:0006536)2.17431724
96Hepatosplenomegaly (HP:0001433)2.17385085
97Thyroiditis (HP:0100646)2.17170833
98Keratoconjunctivitis (HP:0001096)2.14832727
99Abnormality of the septum pellucidum (HP:0007375)2.13594363
100T lymphocytopenia (HP:0005403)2.13104979
101Partial agenesis of the corpus callosum (HP:0001338)2.11735834
102Lower limb muscle weakness (HP:0007340)2.11443416
103Neoplasm of the tracheobronchial system (HP:0100552)2.11387733
104Cupped ear (HP:0000378)2.10434194
105Metabolic alkalosis (HP:0200114)2.10018061
106Synostosis involving the elbow (HP:0003938)2.09838884
107Humeroradial synostosis (HP:0003041)2.09838884
108Abnormal rod and cone electroretinograms (HP:0008323)2.09525991
109Muscle fibrillation (HP:0010546)2.09249649
110Stomach cancer (HP:0012126)2.09211071
111Intestinal atresia (HP:0011100)2.08875775
112Decreased central vision (HP:0007663)2.08410329
113Insulin-resistant diabetes mellitus (HP:0000831)2.05724005
114Spastic tetraparesis (HP:0001285)2.05200057
115Recurrent gram-negative bacterial infections (HP:0005420)2.04600097
116Megalencephaly (HP:0001355)2.04103785
117Agitation (HP:0000713)2.04009860
118Abnormality of T cell number (HP:0011839)2.03862894
119Keratoconjunctivitis sicca (HP:0001097)2.02679485
120Leukocytosis (HP:0001974)2.02655201
121Methylmalonic acidemia (HP:0002912)2.01768659
122Increased density of long bones (HP:0006392)2.01386267
123Segmental peripheral demyelination/remyelination (HP:0003481)2.01345040
124Hypokalemic alkalosis (HP:0001949)1.98530367
125Muscle fiber splitting (HP:0003555)1.97930543
126Renal Fanconi syndrome (HP:0001994)1.97536121
127White forelock (HP:0002211)1.97363953
128Adrenal hypoplasia (HP:0000835)1.97093263
129Progressive neurologic deterioration (HP:0002344)1.96312787
130Facial diplegia (HP:0001349)1.96242163
131Increased CSF protein (HP:0002922)1.96159742
132Patchy hypopigmentation of hair (HP:0011365)1.95992302
133Poor speech (HP:0002465)1.95581668
134Chest pain (HP:0100749)1.95576010
135Foot dorsiflexor weakness (HP:0009027)1.94952483
136Aplasia involving bones of the upper limbs (HP:0009823)1.94425090
137Aplasia of the phalanges of the hand (HP:0009802)1.94425090
138Aplasia involving bones of the extremities (HP:0009825)1.94425090
139Microcytic anemia (HP:0001935)1.94258300
140Absent/shortened dynein arms (HP:0200106)1.92603824
141Neuroendocrine neoplasm (HP:0100634)1.92183918
142Atonic seizures (HP:0010819)1.89711305
143Bowel incontinence (HP:0002607)1.88662026
144Alveolar cell carcinoma (HP:0006519)1.88435762
145Partial duplication of thumb phalanx (HP:0009944)1.88231240
146Hypoplasia of the iris (HP:0007676)1.88185568
147Barrel-shaped chest (HP:0001552)1.87193208
148Erythroderma (HP:0001019)1.86644174
149Gastrointestinal infarctions (HP:0005244)1.85791908
150Testicular neoplasm (HP:0010788)1.85786454
151Symptomatic seizures (HP:0011145)1.84669063
152Urinary incontinence (HP:0000020)1.84283743
153Paraparesis (HP:0002385)1.81576052
154Clonus (HP:0002169)1.81011246
155Diminished movement (HP:0002374)1.81006411
156Decreased motor nerve conduction velocity (HP:0003431)1.80876130
157Anorexia (HP:0002039)1.80149060
158Generalized myoclonic seizures (HP:0002123)1.79180439
159Ketosis (HP:0001946)1.78976672
160Anomalous pulmonary venous return (HP:0010772)1.78625515
161Gowers sign (HP:0003391)1.78550128
162Acute hepatic failure (HP:0006554)1.78280264
163Hyporeflexia of lower limbs (HP:0002600)1.77865470
164Abnormality of calcium-phosphate metabolism (HP:0100530)1.77636507
165Vaginal atresia (HP:0000148)1.77408736
166Medial flaring of the eyebrow (HP:0010747)1.77347654
167Meningitis (HP:0001287)1.77067733
168Abnormality of T cells (HP:0002843)1.76928821
169Bruising susceptibility (HP:0000978)1.76610206
170Morphological abnormality of the pyramidal tract (HP:0002062)1.75311561
171Abnormal large intestine physiology (HP:0012700)1.75256998
172Abnormality of the foot musculature (HP:0001436)1.74862778
173Pulmonary embolism (HP:0002204)1.74381651
174Palpitations (HP:0001962)1.73598144
175Abnormality of the middle phalanges of the toes (HP:0010183)1.72654747
176Menstrual irregularities (HP:0000858)1.72213736
177Abnormality of T cell physiology (HP:0011840)1.71945860
178Abnormal drinking behavior (HP:0030082)1.70770300
179Polydipsia (HP:0001959)1.70770300
180Esophageal atresia (HP:0002032)1.70325399
181Constricted visual fields (HP:0001133)1.69683707
182Dyschromatopsia (HP:0007641)1.69615428
183Chronic otitis media (HP:0000389)1.69150745
184Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68855686
185Relative macrocephaly (HP:0004482)1.68782593
186Joint swelling (HP:0001386)1.68708190
187Abnormal ciliary motility (HP:0012262)1.67822846
188Disproportionate short-trunk short stature (HP:0003521)1.67213282
1893-Methylglutaconic aciduria (HP:0003535)1.67076054
190Abnormality of the renal cortex (HP:0011035)1.67009581
191Papilledema (HP:0001085)1.66947833
192Genital tract atresia (HP:0001827)1.66763381
193Abolished electroretinogram (ERG) (HP:0000550)1.66241778
194Renal cortical cysts (HP:0000803)1.66222739
195Dynein arm defect of respiratory motile cilia (HP:0012255)1.65670720
196Abnormal hair whorl (HP:0010721)1.65283557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.59393400
2FRK4.98857201
3OXSR14.85655695
4EPHB13.07809547
5BCR3.03018351
6RIPK42.92297807
7CDK192.83408925
8TNIK2.66902692
9WNK42.65192957
10PKN12.48297993
11MET2.37691294
12PBK2.22704839
13LIMK12.12658104
14WNK12.10903756
15TEC2.07935774
16FGFR22.07263697
17TAOK12.06110085
18WNK32.03062413
19ICK2.02100506
20TAOK32.00379394
21CSNK1G31.94438121
22BTK1.94211702
23MAP2K31.93472118
24GRK61.91757162
25YES11.90561281
26CSNK1A1L1.88406336
27NEK61.87471350
28PRPF4B1.83739503
29TNK21.79200959
30DAPK21.77718283
31PNCK1.75915181
32MAPKAPK51.74950480
33UHMK11.72942571
34MYLK1.71233489
35NTRK11.62354588
36EPHA31.58042261
37IRAK41.53888122
38ROCK21.52607803
39CAMK2B1.51737679
40CSNK1G11.50928636
41MAP2K61.49777586
42NLK1.49210814
43BLK1.45784908
44CLK11.45376941
45CSNK1G21.45090995
46SYK1.42391425
47PAK61.39699834
48FGR1.38955075
49EPHA41.30754887
50STK241.28148437
51CAMK2D1.26217402
52PIK3CG1.25536033
53MST41.25390907
54HCK1.23504622
55PINK11.22310426
56NUAK11.21123173
57MAP4K11.20268991
58ZAP701.16617428
59TXK1.14153674
60GRK11.12602849
61TESK21.10473928
62ERBB31.09091196
63LYN1.07815416
64EIF2AK11.07018439
65MAP3K41.03458399
66CASK1.01573910
67CSF1R1.01133545
68FGFR31.00668142
69MAP3K50.99124642
70PAK30.96070246
71MAP2K40.95665769
72CAMK2G0.95093238
73MAP3K120.94713077
74SGK2230.93165995
75SGK4940.93165995
76MAPK150.91792801
77CDK140.91283045
78STK30.90340201
79TYRO30.90220246
80MARK10.90201194
81IKBKE0.88451950
82PLK20.86635944
83PRKCQ0.86321410
84LCK0.84736437
85JAK20.83466976
86TYK20.83207968
87ARAF0.82815982
88CDK50.81123401
89JAK10.80728831
90PASK0.80412992
91DYRK20.79840946
92ERBB40.79282997
93CDK150.78049192
94MARK20.77238297
95ACVR1B0.76390801
96CAMK2A0.75391896
97TRPM70.75286502
98JAK30.75065984
99MAP3K30.74211273
100BMPR20.73242281
101BMPR1B0.73150729
102CDK180.72824137
103STK40.70362717
104CDK11A0.70235747
105MUSK0.69312952
106SGK20.69001364
107MAP3K10.68841413
108MAP3K130.66160128
109MAP4K20.65354031
110STK38L0.64808796
111IRAK20.64726163
112PRKD10.63370181
113IKBKB0.63058733
114GRK50.62899255
115ADRBK10.62730558
116PDPK10.60839513
117FER0.60158075
118INSRR0.59790237
119FYN0.58732157
120MAP3K60.58181612
121BMX0.57917806
122PRKCE0.57730585
123KSR20.54131019
124KIT0.54006517
125NTRK30.52586261
126PHKG20.51537317
127PHKG10.51537317
128DYRK30.51275234
129CSNK1D0.49909846
130PRKG10.45513269
131STK110.45077852
132FLT30.44650897
133PRKCH0.44039835
134RPS6KA50.42693518
135ITK0.41226194
136TRIM280.41113604
137MATK0.40704834
138CSNK1A10.39320894
139IRAK10.37772109
140MAP2K20.37451556
141DYRK1B0.36675683
142CAMK1G0.35772749
143PRKACB0.35606323
144PAK10.34895980
145PIK3CA0.34311440
146MAPK70.33512040
147GSK3A0.32641698
148NTRK20.31910795
149STK160.30962062
150PDGFRB0.30907271
151MAP3K20.30301229
152MAPK130.29341610
153ADRBK20.29169610
154OBSCN0.28491397
155HIPK20.28209868
156FES0.28127591
157MELK0.27511688
158ROCK10.26840275
159INSR0.26654379
160PDK10.26266600
161PRKACA0.25038427
162MAPK100.23786611
163DMPK0.23685047
164MAP3K90.22819629
165PTK2B0.22612718
166DDR20.22513210
167CSK0.21797696
168GRK70.21241957

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.25826274
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.19055646
3Steroid biosynthesis_Homo sapiens_hsa001004.58792751
4Fatty acid elongation_Homo sapiens_hsa000624.32196840
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49686239
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.18067285
7Ether lipid metabolism_Homo sapiens_hsa005653.10574987
8Platelet activation_Homo sapiens_hsa046112.93932884
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.27792067
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24726947
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.24096988
12Type I diabetes mellitus_Homo sapiens_hsa049402.21342618
13Oxidative phosphorylation_Homo sapiens_hsa001902.16022708
14Sulfur metabolism_Homo sapiens_hsa009202.13630527
15Protein export_Homo sapiens_hsa030602.11900336
16Axon guidance_Homo sapiens_hsa043601.99526392
17Sphingolipid metabolism_Homo sapiens_hsa006001.97825668
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78339354
19Vitamin B6 metabolism_Homo sapiens_hsa007501.66406419
20Hematopoietic cell lineage_Homo sapiens_hsa046401.60564332
21Linoleic acid metabolism_Homo sapiens_hsa005911.56762144
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52333231
23Leishmaniasis_Homo sapiens_hsa051401.51454589
24Parkinsons disease_Homo sapiens_hsa050121.48817740
25Osteoclast differentiation_Homo sapiens_hsa043801.46525240
26Butanoate metabolism_Homo sapiens_hsa006501.46112044
27Histidine metabolism_Homo sapiens_hsa003401.45478482
28Alzheimers disease_Homo sapiens_hsa050101.44931211
29Legionellosis_Homo sapiens_hsa051341.44136409
30Primary immunodeficiency_Homo sapiens_hsa053401.43131347
31Insulin secretion_Homo sapiens_hsa049111.42093274
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40286228
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35798089
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32853316
35Serotonergic synapse_Homo sapiens_hsa047261.32353323
36GABAergic synapse_Homo sapiens_hsa047271.27318777
37Chemokine signaling pathway_Homo sapiens_hsa040621.25786410
38Renal cell carcinoma_Homo sapiens_hsa052111.23928651
39Tuberculosis_Homo sapiens_hsa051521.23903595
40Glutamatergic synapse_Homo sapiens_hsa047241.22902737
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22241466
42Type II diabetes mellitus_Homo sapiens_hsa049301.20961192
43Staphylococcus aureus infection_Homo sapiens_hsa051501.19266085
44Vibrio cholerae infection_Homo sapiens_hsa051101.08765137
45Arginine and proline metabolism_Homo sapiens_hsa003301.08135209
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.07183890
47Tight junction_Homo sapiens_hsa045301.04825477
48Long-term depression_Homo sapiens_hsa047301.03155450
49Morphine addiction_Homo sapiens_hsa050321.02728937
50Collecting duct acid secretion_Homo sapiens_hsa049661.02716563
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97882818
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96434416
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94849670
54T cell receptor signaling pathway_Homo sapiens_hsa046600.90159088
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.89959632
56Cardiac muscle contraction_Homo sapiens_hsa042600.87668027
57Autoimmune thyroid disease_Homo sapiens_hsa053200.85404299
58Endocytosis_Homo sapiens_hsa041440.84693336
59Rheumatoid arthritis_Homo sapiens_hsa053230.84537517
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83884859
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82235908
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81670749
63Arachidonic acid metabolism_Homo sapiens_hsa005900.81232182
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80796533
65Measles_Homo sapiens_hsa051620.80705787
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76525691
67Glutathione metabolism_Homo sapiens_hsa004800.75668010
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.74949756
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.74567479
70Graft-versus-host disease_Homo sapiens_hsa053320.74520652
71B cell receptor signaling pathway_Homo sapiens_hsa046620.74155493
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.74121836
73Ras signaling pathway_Homo sapiens_hsa040140.73720480
74Cocaine addiction_Homo sapiens_hsa050300.73659442
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73145912
76Huntingtons disease_Homo sapiens_hsa050160.72742015
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69948506
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68950113
79Phototransduction_Homo sapiens_hsa047440.68377617
80Lysosome_Homo sapiens_hsa041420.67557509
81Circadian entrainment_Homo sapiens_hsa047130.66783204
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66144753
83Fatty acid metabolism_Homo sapiens_hsa012120.65761239
84Ovarian steroidogenesis_Homo sapiens_hsa049130.65411865
85ErbB signaling pathway_Homo sapiens_hsa040120.65360227
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.65271390
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63662977
88African trypanosomiasis_Homo sapiens_hsa051430.63258575
89Olfactory transduction_Homo sapiens_hsa047400.62874689
90Nicotine addiction_Homo sapiens_hsa050330.62696301
91Salivary secretion_Homo sapiens_hsa049700.62487694
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62064668
93Shigellosis_Homo sapiens_hsa051310.61974655
94Dorso-ventral axis formation_Homo sapiens_hsa043200.61064011
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60767158
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59474284
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.59235925
98Malaria_Homo sapiens_hsa051440.58802296
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57640569
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57029161
101Allograft rejection_Homo sapiens_hsa053300.56469351
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55899996
103Dopaminergic synapse_Homo sapiens_hsa047280.55151591
104FoxO signaling pathway_Homo sapiens_hsa040680.54947932
105Propanoate metabolism_Homo sapiens_hsa006400.54922792
106Cholinergic synapse_Homo sapiens_hsa047250.54307039
107Pancreatic secretion_Homo sapiens_hsa049720.53485956
108Phagosome_Homo sapiens_hsa041450.52339070
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51209891
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51181570
111Inositol phosphate metabolism_Homo sapiens_hsa005620.51054261
112ECM-receptor interaction_Homo sapiens_hsa045120.50867794
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50458960
114Synaptic vesicle cycle_Homo sapiens_hsa047210.50028866
115Hedgehog signaling pathway_Homo sapiens_hsa043400.48910577
116Antigen processing and presentation_Homo sapiens_hsa046120.48722504
117Mineral absorption_Homo sapiens_hsa049780.47507741
118Calcium signaling pathway_Homo sapiens_hsa040200.47336989
119Gastric acid secretion_Homo sapiens_hsa049710.47263897
120Nitrogen metabolism_Homo sapiens_hsa009100.46586089
121Insulin resistance_Homo sapiens_hsa049310.45247714
122Peroxisome_Homo sapiens_hsa041460.44120205
123Fatty acid biosynthesis_Homo sapiens_hsa000610.44045954
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43941237
125Folate biosynthesis_Homo sapiens_hsa007900.42739307
126Rap1 signaling pathway_Homo sapiens_hsa040150.40824810
127Starch and sucrose metabolism_Homo sapiens_hsa005000.40733825
128Metabolic pathways_Homo sapiens_hsa011000.40517940
129Oxytocin signaling pathway_Homo sapiens_hsa049210.40063832
130Taste transduction_Homo sapiens_hsa047420.36520016
131Gap junction_Homo sapiens_hsa045400.35492119
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35293181
133Choline metabolism in cancer_Homo sapiens_hsa052310.35196944
134cAMP signaling pathway_Homo sapiens_hsa040240.34127685
135Renin secretion_Homo sapiens_hsa049240.33757945
136Regulation of autophagy_Homo sapiens_hsa041400.30969919
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30648267
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30332490
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27904520
140Amphetamine addiction_Homo sapiens_hsa050310.27782655
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27536420
142Alcoholism_Homo sapiens_hsa050340.26951705
143MAPK signaling pathway_Homo sapiens_hsa040100.26688990
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25850392
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24328378
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23828054
147Chemical carcinogenesis_Homo sapiens_hsa052040.21382397

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