TSPAN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.28100580
2neuron cell-cell adhesion (GO:0007158)4.21780297
3axonemal dynein complex assembly (GO:0070286)4.21719157
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15188532
5epithelial cilium movement (GO:0003351)4.02782296
6synaptic vesicle maturation (GO:0016188)4.01718554
7cilium movement (GO:0003341)3.98434090
8locomotory exploration behavior (GO:0035641)3.97396167
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93380331
10central nervous system myelination (GO:0022010)3.87030351
11axon ensheathment in central nervous system (GO:0032291)3.87030351
12neuronal action potential propagation (GO:0019227)3.75238508
13cellular potassium ion homeostasis (GO:0030007)3.74686155
14vocalization behavior (GO:0071625)3.74484789
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69104184
16regulation of synaptic vesicle exocytosis (GO:2000300)3.68960013
17protein localization to synapse (GO:0035418)3.67425317
18glutamate secretion (GO:0014047)3.61747347
19cilium or flagellum-dependent cell motility (GO:0001539)3.60872484
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51119307
21neuron recognition (GO:0008038)3.46941566
22positive regulation of mitochondrial fission (GO:0090141)3.45592212
23intraciliary transport (GO:0042073)3.44494202
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42153468
25layer formation in cerebral cortex (GO:0021819)3.41561614
26pyrimidine nucleobase catabolic process (GO:0006208)3.40245858
27exploration behavior (GO:0035640)3.39348414
28sodium ion export (GO:0071436)3.32468690
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30020869
30axonal fasciculation (GO:0007413)3.25345068
31regulation of synapse structural plasticity (GO:0051823)3.22813378
32cell communication by electrical coupling (GO:0010644)3.21564456
33transmission of nerve impulse (GO:0019226)3.20608464
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.19881028
35dendritic spine morphogenesis (GO:0060997)3.18316258
36regulation of glutamate receptor signaling pathway (GO:1900449)3.18198583
37glutamate receptor signaling pathway (GO:0007215)3.18189847
38regulation of synaptic vesicle transport (GO:1902803)3.17961640
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14414845
40establishment of mitochondrion localization (GO:0051654)3.11103314
41nucleobase catabolic process (GO:0046113)3.06907102
42response to auditory stimulus (GO:0010996)3.02229904
43regulation of neuronal synaptic plasticity (GO:0048168)3.02219185
44innervation (GO:0060384)3.01696909
45calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.00159864
46synaptic transmission, glutamatergic (GO:0035249)2.97544104
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97119737
48gamma-aminobutyric acid signaling pathway (GO:0007214)2.96470184
49regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96358716
50neurotransmitter secretion (GO:0007269)2.95749318
51potassium ion homeostasis (GO:0055075)2.94052504
52presynaptic membrane assembly (GO:0097105)2.93901658
53positive regulation of potassium ion transmembrane transport (GO:1901381)2.93322144
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92423904
55long-term synaptic potentiation (GO:0060291)2.91912065
56neuron-neuron synaptic transmission (GO:0007270)2.90165396
57postsynaptic membrane organization (GO:0001941)2.89356829
58response to pheromone (GO:0019236)2.86676182
59membrane repolarization (GO:0086009)2.86126307
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84459661
61presynaptic membrane organization (GO:0097090)2.84253741
62regulation of vesicle fusion (GO:0031338)2.82083639
63positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80187485
64neurotransmitter catabolic process (GO:0042135)2.79726466
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79267273
66dendrite morphogenesis (GO:0048813)2.79235415
67potassium ion import (GO:0010107)2.79024298
68positive regulation of potassium ion transport (GO:0043268)2.78880304
69retinal ganglion cell axon guidance (GO:0031290)2.78860657
70mating behavior (GO:0007617)2.76083420
71positive regulation of synapse assembly (GO:0051965)2.74054190
72membrane hyperpolarization (GO:0060081)2.73891685
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.73749198
74synapse assembly (GO:0007416)2.72685593
75nonmotile primary cilium assembly (GO:0035058)2.70386511
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69406992
77regulation of cilium movement (GO:0003352)2.68858884
78negative regulation of neurotransmitter transport (GO:0051589)2.67733205
79auditory behavior (GO:0031223)2.66882534
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65142839
81cholesterol biosynthetic process (GO:0006695)2.64632125
82neuronal ion channel clustering (GO:0045161)2.63850776
83neurotransmitter transport (GO:0006836)2.63761084
84regulation of amyloid precursor protein catabolic process (GO:1902991)2.61999458
85C4-dicarboxylate transport (GO:0015740)2.61141635
86regulation of voltage-gated calcium channel activity (GO:1901385)2.60093446
87activation of protein kinase A activity (GO:0034199)2.59309633
88mechanosensory behavior (GO:0007638)2.58992614
89synapse organization (GO:0050808)2.58390167
90synaptic vesicle endocytosis (GO:0048488)2.58345426
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57809826
92long-term memory (GO:0007616)2.56416034
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55582941
94photoreceptor cell differentiation (GO:0046530)2.55550383
95eye photoreceptor cell differentiation (GO:0001754)2.55550383
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55392714
97cerebellar granule cell differentiation (GO:0021707)2.54640316
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54573079
99detection of calcium ion (GO:0005513)2.53691598
100L-amino acid import (GO:0043092)2.53601757
101positive regulation of synapse maturation (GO:0090129)2.53422624
102positive regulation of membrane potential (GO:0045838)2.53396783
103cilium assembly (GO:0042384)2.53016790
104regulation of synaptic plasticity (GO:0048167)2.52700885
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.52583704
106membrane repolarization during action potential (GO:0086011)2.52264841
107cilium organization (GO:0044782)2.52215287
108dendritic spine organization (GO:0097061)2.52103730
109regulation of dendritic spine morphogenesis (GO:0061001)2.52056367
110proline transport (GO:0015824)2.51806162
111motile cilium assembly (GO:0044458)2.51565754
112axoneme assembly (GO:0035082)2.51250307
113left/right pattern formation (GO:0060972)2.50314201
114gamma-aminobutyric acid transport (GO:0015812)2.49956073
115regulation of potassium ion transmembrane transport (GO:1901379)2.49741979
116neurotransmitter-gated ion channel clustering (GO:0072578)2.49515119
117regulation of neurotransmitter secretion (GO:0046928)2.49332136
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49015766
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48324485
120negative regulation of microtubule polymerization (GO:0031115)2.48200472
121cellular sodium ion homeostasis (GO:0006883)2.46633812
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45406145
123regulation of respiratory system process (GO:0044065)2.44254585
124regulation of membrane repolarization (GO:0060306)2.43266503
125primary alcohol catabolic process (GO:0034310)2.43122145
126protein retention in ER lumen (GO:0006621)2.41497091
127carnitine metabolic process (GO:0009437)2.41210489
128sterol biosynthetic process (GO:0016126)2.40640504
129cilium morphogenesis (GO:0060271)2.40337823
130positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.39576650
131mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.39576650
132negative regulation of protein localization to cell surface (GO:2000009)2.38170810
133cGMP-mediated signaling (GO:0019934)2.36068151
134lipid particle organization (GO:0034389)2.34209314
135acidic amino acid transport (GO:0015800)2.33089527
136L-serine transport (GO:0015825)2.30795628
137peroxisome fission (GO:0016559)2.29168035
138protein localization to cilium (GO:0061512)2.25915869
139axon extension involved in axon guidance (GO:0048846)2.21730065
140neuron projection extension involved in neuron projection guidance (GO:1902284)2.21730065
141vascular smooth muscle contraction (GO:0014829)2.21295613
142ethanol oxidation (GO:0006069)2.20799618
143fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.20140345
144L-glutamate transport (GO:0015813)2.19693042
145negative regulation of oligodendrocyte differentiation (GO:0048715)2.19561179
146vitamin transmembrane transport (GO:0035461)2.18650360
147regulation of mitochondrial fission (GO:0090140)2.17805285
148maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.16899616
149sodium ion homeostasis (GO:0055078)2.15532380
150neurotransmitter uptake (GO:0001504)2.15414713
151limb development (GO:0060173)2.14721840
152appendage development (GO:0048736)2.14721840
153polyketide metabolic process (GO:0030638)2.13245251
154doxorubicin metabolic process (GO:0044598)2.13245251
155daunorubicin metabolic process (GO:0044597)2.13245251
156regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.12977673
157cerebral cortex radially oriented cell migration (GO:0021799)2.11734608
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.11285760
159mitochondrion transport along microtubule (GO:0047497)2.11285760
160ubiquinone metabolic process (GO:0006743)2.08047449
161isoprenoid biosynthetic process (GO:0008299)2.07783635
162regulation of cell communication by electrical coupling (GO:0010649)2.07549656
163axon extension (GO:0048675)2.07324953
164alpha-linolenic acid metabolic process (GO:0036109)2.07260751
165oligodendrocyte differentiation (GO:0048709)2.05889185
166glycosphingolipid biosynthetic process (GO:0006688)2.04511780
167neurotransmitter biosynthetic process (GO:0042136)2.02776526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17632906
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.25982084
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21878924
4GBX2_23144817_ChIP-Seq_PC3_Human3.20148078
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10515519
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84438503
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79170243
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79170243
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.78490614
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.78290665
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.75908815
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73004776
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.66285289
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63476286
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56406273
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.42389317
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39864866
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.31143071
19REST_21632747_ChIP-Seq_MESCs_Mouse2.23746389
20DROSHA_22980978_ChIP-Seq_HELA_Human2.04624764
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.93511776
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.89319162
23AR_21572438_ChIP-Seq_LNCaP_Human1.89297759
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.83503119
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83201462
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79206628
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79005198
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77840854
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.69768228
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67095038
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65830643
32* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63828739
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53942980
34ZNF274_21170338_ChIP-Seq_K562_Hela1.52163417
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49841458
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48312098
37* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48281569
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48260732
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.47449399
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46014013
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45767527
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45545766
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42713461
44TAF15_26573619_Chip-Seq_HEK293_Human1.41747973
45SMAD4_21799915_ChIP-Seq_A2780_Human1.40971927
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40098022
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.38448337
48P300_19829295_ChIP-Seq_ESCs_Human1.37294559
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.34766252
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34206026
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32366423
52IGF1R_20145208_ChIP-Seq_DFB_Human1.32146569
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31471028
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.31344943
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30588315
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30280120
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30196125
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29794353
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.29438900
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27053207
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.26284491
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26203984
63VDR_22108803_ChIP-Seq_LS180_Human1.22067037
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.19510629
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16585233
66FUS_26573619_Chip-Seq_HEK293_Human1.16516922
67* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15684186
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14736838
69RNF2_27304074_Chip-Seq_NSC_Mouse1.13407687
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11922388
71AR_25329375_ChIP-Seq_VCAP_Human1.11470456
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11391059
73* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11390216
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10584722
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10338435
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09621500
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.06002431
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05324640
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04725378
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.04669702
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.04534612
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03257355
83CLOCK_20551151_ChIP-Seq_293T_Human1.02446302
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.02034203
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01177102
86STAT3_23295773_ChIP-Seq_U87_Human1.00730775
87AR_19668381_ChIP-Seq_PC3_Human1.00396123
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00107376
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.99250717
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99026902
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98828044
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98612304
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97771788
94ER_23166858_ChIP-Seq_MCF-7_Human0.97765699
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96187324
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96179887
97EWS_26573619_Chip-Seq_HEK293_Human0.95215059
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94741647
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94431315
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94200746
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.93086839
102* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92958369
103KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92837716
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92039674
105CBP_20019798_ChIP-Seq_JUKART_Human0.92039674
106RUNX2_22187159_ChIP-Seq_PCA_Human0.91681819
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90555053
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90013265
109TP53_18474530_ChIP-ChIP_U2OS_Human0.89732441
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89706463
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.88814438
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88534715
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88367797
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88201870
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87593761
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.87436245
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86265004
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.85791573
119SOX9_26525672_Chip-Seq_HEART_Mouse0.85778668
120JUN_21703547_ChIP-Seq_K562_Human0.85500559
121TCF4_23295773_ChIP-Seq_U87_Human0.84216244
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.83795894
123BCAT_22108803_ChIP-Seq_LS180_Human0.83498105
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82824874
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82484036
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82093618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.23291566
2MP0003880_abnormal_central_pattern4.17812109
3MP0003635_abnormal_synaptic_transmissio3.11454404
4MP0004270_analgesia3.10061701
5MP0009745_abnormal_behavioral_response2.52175304
6MP0002064_seizures2.49672995
7MP0002063_abnormal_learning/memory/cond2.45723078
8MP0002272_abnormal_nervous_system2.31728668
9MP0002734_abnormal_mechanical_nocicepti2.30742372
10MP0005423_abnormal_somatic_nervous2.29013462
11MP0001486_abnormal_startle_reflex2.28494928
12MP0003329_amyloid_beta_deposits2.22825802
13MP0009046_muscle_twitch2.22689211
14MP0001968_abnormal_touch/_nociception2.20844219
15MP0002572_abnormal_emotion/affect_behav2.16571025
16MP0004858_abnormal_nervous_system2.16404294
17MP0003136_yellow_coat_color2.01851608
18MP0000778_abnormal_nervous_system1.99650071
19MP0008789_abnormal_olfactory_epithelium1.86350651
20MP0009780_abnormal_chondrocyte_physiolo1.82221243
21MP0005248_abnormal_Harderian_gland1.81985528
22MP0001529_abnormal_vocalization1.81132754
23MP0001984_abnormal_olfaction1.80694461
24MP0002733_abnormal_thermal_nociception1.79309985
25MP0005645_abnormal_hypothalamus_physiol1.76219444
26MP0002736_abnormal_nociception_after1.74207359
27MP0004885_abnormal_endolymph1.73643270
28MP0000566_synostosis1.73031390
29MP0001440_abnormal_grooming_behavior1.72372826
30MP0002067_abnormal_sensory_capabilities1.72069284
31MP0006276_abnormal_autonomic_nervous1.71600331
32MP0003122_maternal_imprinting1.70462067
33MP0002184_abnormal_innervation1.68817657
34MP0001970_abnormal_pain_threshold1.68502151
35MP0002909_abnormal_adrenal_gland1.66743690
36MP0000013_abnormal_adipose_tissue1.63310482
37MP0002735_abnormal_chemical_nociception1.61702560
38MP0001501_abnormal_sleep_pattern1.58187712
39MP0001905_abnormal_dopamine_level1.58035464
40MP0001502_abnormal_circadian_rhythm1.56826602
41MP0002557_abnormal_social/conspecific_i1.56430532
42MP0005646_abnormal_pituitary_gland1.55616074
43MP0008569_lethality_at_weaning1.54577904
44MP0000955_abnormal_spinal_cord1.53693750
45MP0000920_abnormal_myelination1.48001235
46MP0003634_abnormal_glial_cell1.46601961
47MP0002882_abnormal_neuron_morphology1.45197870
48MP0004924_abnormal_behavior1.44201557
49MP0005386_behavior/neurological_phenoty1.44201557
50MP0000751_myopathy1.43253526
51MP0005551_abnormal_eye_electrophysiolog1.40141840
52MP0004043_abnormal_pH_regulation1.39453732
53MP0004145_abnormal_muscle_electrophysio1.38735918
54MP0004133_heterotaxia1.37766670
55MP0003283_abnormal_digestive_organ1.35149026
56MP0006072_abnormal_retinal_apoptosis1.35072987
57MP0004142_abnormal_muscle_tone1.33504893
58MP0002837_dystrophic_cardiac_calcinosis1.29927016
59MP0001485_abnormal_pinna_reflex1.29185277
60MP0002066_abnormal_motor_capabilities/c1.25441058
61MP0002638_abnormal_pupillary_reflex1.24474901
62MP0002822_catalepsy1.23824477
63MP0004811_abnormal_neuron_physiology1.23241124
64MP0003011_delayed_dark_adaptation1.20724463
65MP0004742_abnormal_vestibular_system1.15280956
66MP0000631_abnormal_neuroendocrine_gland1.14802889
67MP0000537_abnormal_urethra_morphology1.13818219
68MP0005187_abnormal_penis_morphology1.13010040
69MP0010030_abnormal_orbit_morphology1.12441865
70MP0002233_abnormal_nose_morphology1.11451333
71MP0010386_abnormal_urinary_bladder1.11381160
72MP0003690_abnormal_glial_cell1.10573639
73MP0005623_abnormal_meninges_morphology1.08555050
74MP0001963_abnormal_hearing_physiology1.07997406
75MP0002229_neurodegeneration1.07338614
76MP0002090_abnormal_vision1.07208883
77MP0002152_abnormal_brain_morphology1.06080308
78MP0001299_abnormal_eye_distance/1.06038219
79MP0003879_abnormal_hair_cell1.05840650
80MP0003633_abnormal_nervous_system1.05606798
81MP0004233_abnormal_muscle_weight1.03359888
82MP0002752_abnormal_somatic_nervous1.02844718
83MP0005171_absent_coat_pigmentation1.00747963
84MP0005379_endocrine/exocrine_gland_phen0.99536211
85MP0004215_abnormal_myocardial_fiber0.98399874
86MP0004147_increased_porphyrin_level0.97074543
87MP0003137_abnormal_impulse_conducting0.96975754
88MP0003631_nervous_system_phenotype0.96949215
89MP0004019_abnormal_vitamin_homeostasis0.95503215
90MP0005085_abnormal_gallbladder_physiolo0.93758766
91MP0002876_abnormal_thyroid_physiology0.93702194
92MP0000462_abnormal_digestive_system0.93388402
93MP0001293_anophthalmia0.91475037
94MP0000026_abnormal_inner_ear0.91464240
95MP0002653_abnormal_ependyma_morphology0.89986183
96MP0005253_abnormal_eye_physiology0.89933643
97MP0003183_abnormal_peptide_metabolism0.89302265
98MP0003632_abnormal_nervous_system0.87576802
99MP0005391_vision/eye_phenotype0.87345554
100MP0001188_hyperpigmentation0.87341608
101MP0000604_amyloidosis0.84887665
102MP0002234_abnormal_pharynx_morphology0.84271092
103MP0003121_genomic_imprinting0.83832561
104MP0005394_taste/olfaction_phenotype0.83521927
105MP0005499_abnormal_olfactory_system0.83521927
106MP0003861_abnormal_nervous_system0.82291441
107MP0002102_abnormal_ear_morphology0.82052670
108MP0005670_abnormal_white_adipose0.80815546
109MP0002249_abnormal_larynx_morphology0.79759405
110MP0005195_abnormal_posterior_eye0.78060892
111MP0004085_abnormal_heartbeat0.77160762
112MP0003942_abnormal_urinary_system0.77050864
113MP0002069_abnormal_eating/drinking_beha0.76902347
114MP0001664_abnormal_digestion0.76222585
115MP0003119_abnormal_digestive_system0.75190348
116MP0000534_abnormal_ureter_morphology0.73966908
117MP0001348_abnormal_lacrimal_gland0.73052122
118MP0004036_abnormal_muscle_relaxation0.71085152
119MP0001177_atelectasis0.69921205
120MP0000747_muscle_weakness0.69505051
121MP0004134_abnormal_chest_morphology0.68139324
122MP0002751_abnormal_autonomic_nervous0.68029116
123MP0000003_abnormal_adipose_tissue0.67978341
124MP0000049_abnormal_middle_ear0.67868933

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.74284368
2Focal motor seizures (HP:0011153)4.41352205
3Myokymia (HP:0002411)4.28576602
4Abnormal respiratory epithelium morphology (HP:0012253)4.17875625
5Abnormal respiratory motile cilium morphology (HP:0005938)4.17875625
6Abnormal respiratory motile cilium physiology (HP:0012261)4.17449594
7Abnormal ciliary motility (HP:0012262)4.10416240
8Neurofibrillary tangles (HP:0002185)4.10044405
9Rhinitis (HP:0012384)3.92351873
10Visual hallucinations (HP:0002367)3.82170249
11Retinal dysplasia (HP:0007973)3.62633725
12Megalencephaly (HP:0001355)3.51461660
13Epileptic encephalopathy (HP:0200134)3.47009975
14Supranuclear gaze palsy (HP:0000605)3.44884680
15Cerebral inclusion bodies (HP:0100314)3.43720035
16Pheochromocytoma (HP:0002666)3.40899617
17True hermaphroditism (HP:0010459)3.35114805
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.32663477
19Absent/shortened dynein arms (HP:0200106)3.32663477
20Occipital encephalocele (HP:0002085)3.24673368
21Focal seizures (HP:0007359)3.22147449
22Abnormality of the lower motor neuron (HP:0002366)3.09773065
23Neuroendocrine neoplasm (HP:0100634)3.09496774
24Atonic seizures (HP:0010819)3.05069867
25Ankle clonus (HP:0011448)2.94543781
26Pancreatic fibrosis (HP:0100732)2.77040789
27Type II lissencephaly (HP:0007260)2.76669839
28Action tremor (HP:0002345)2.72431075
29Hemiparesis (HP:0001269)2.69554392
30Exercise-induced muscle cramps (HP:0003710)2.67396537
31Hyperglycinemia (HP:0002154)2.67356286
32Amyotrophic lateral sclerosis (HP:0007354)2.66176980
33Absence seizures (HP:0002121)2.65986700
34Progressive cerebellar ataxia (HP:0002073)2.65824155
35Degeneration of anterior horn cells (HP:0002398)2.52705307
36Abnormality of the anterior horn cell (HP:0006802)2.52705307
37Dialeptic seizures (HP:0011146)2.44057538
38Truncal ataxia (HP:0002078)2.42298015
39Anxiety (HP:0000739)2.41883486
40Chronic bronchitis (HP:0004469)2.41275400
41Aplasia involving bones of the upper limbs (HP:0009823)2.40531199
42Aplasia of the phalanges of the hand (HP:0009802)2.40531199
43Aplasia involving bones of the extremities (HP:0009825)2.40531199
44Gait imbalance (HP:0002141)2.40108541
45Postaxial foot polydactyly (HP:0001830)2.39736203
46Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.38997546
47Generalized tonic-clonic seizures (HP:0002069)2.36078245
48Abnormality of serine family amino acid metabolism (HP:0010894)2.35649872
49Abnormality of glycine metabolism (HP:0010895)2.35649872
50Depression (HP:0000716)2.34980161
51Molar tooth sign on MRI (HP:0002419)2.30373106
52Abnormality of midbrain morphology (HP:0002418)2.30373106
53Dysmetria (HP:0001310)2.30162963
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.26913776
55Hyperactive renin-angiotensin system (HP:0000841)2.24769579
56Nephronophthisis (HP:0000090)2.22934328
57Postaxial hand polydactyly (HP:0001162)2.19231833
58Abnormal eating behavior (HP:0100738)2.19043708
59Hyperglycinuria (HP:0003108)2.18021455
60Dysdiadochokinesis (HP:0002075)2.17852274
61Limb dystonia (HP:0002451)2.17353978
62Increased circulating renin level (HP:0000848)2.16376118
63Congenital primary aphakia (HP:0007707)2.13432253
64Intention tremor (HP:0002080)2.11751844
65Febrile seizures (HP:0002373)2.11159438
66Cystic liver disease (HP:0006706)2.07595294
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.06974323
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06974323
69Acute necrotizing encephalopathy (HP:0006965)2.05839837
70Pancreatic cysts (HP:0001737)2.05513143
71Vaginal atresia (HP:0000148)2.05502539
72Central scotoma (HP:0000603)2.04901211
73Progressive inability to walk (HP:0002505)2.04868659
74EEG with generalized epileptiform discharges (HP:0011198)2.04563365
75Broad foot (HP:0001769)2.04413668
76Epileptiform EEG discharges (HP:0011182)2.03779370
77Genital tract atresia (HP:0001827)2.02657835
78Myoglobinuria (HP:0002913)2.02416478
79Broad-based gait (HP:0002136)2.02120810
80Abnormal mitochondria in muscle tissue (HP:0008316)2.01730969
81Scanning speech (HP:0002168)2.01304177
82Insidious onset (HP:0003587)2.00986746
83Termporal pattern (HP:0011008)2.00986746
84Medial flaring of the eyebrow (HP:0010747)1.97277050
85Prolonged QT interval (HP:0001657)1.96752784
86Spastic gait (HP:0002064)1.96443440
87Sensorimotor neuropathy (HP:0007141)1.96349520
88Humeroradial synostosis (HP:0003041)1.95849217
89Synostosis involving the elbow (HP:0003938)1.95849217
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.95148597
91Nephrogenic diabetes insipidus (HP:0009806)1.94230716
92Neoplasm of the peripheral nervous system (HP:0100007)1.93696721
93Peripheral hypomyelination (HP:0007182)1.92896443
94Hyperventilation (HP:0002883)1.92216884
95Abnormality of the corticospinal tract (HP:0002492)1.91042074
96Hypsarrhythmia (HP:0002521)1.90540228
97Lissencephaly (HP:0001339)1.90081641
98Polyphagia (HP:0002591)1.89559677
99Lower limb muscle weakness (HP:0007340)1.89307985
100Tubulointerstitial nephritis (HP:0001970)1.88254658
101Poor coordination (HP:0002370)1.87842362
102Agitation (HP:0000713)1.87095400
103Cortical dysplasia (HP:0002539)1.86326738
104Clumsiness (HP:0002312)1.86177244
105Amblyopia (HP:0000646)1.84145188
106Progressive macrocephaly (HP:0004481)1.84044470
107Mutism (HP:0002300)1.84025740
108Sclerocornea (HP:0000647)1.81816341
109Bronchiectasis (HP:0002110)1.78214611
110Abnormality of calcium-phosphate metabolism (HP:0100530)1.78077591
111Abnormality of binocular vision (HP:0011514)1.77171385
112Diplopia (HP:0000651)1.77171385
113Specific learning disability (HP:0001328)1.73868048
114Psychosis (HP:0000709)1.73134832
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72924382
116Hypoplasia of the brainstem (HP:0002365)1.72924382
117Scotoma (HP:0000575)1.72818305
118Congenital hepatic fibrosis (HP:0002612)1.72271827
119Drooling (HP:0002307)1.72158807
120Excessive salivation (HP:0003781)1.72158807
121Abnormality of macular pigmentation (HP:0008002)1.71648618
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71312034
123Short tibia (HP:0005736)1.71299589
124Metabolic alkalosis (HP:0200114)1.70897614
125Ventricular fibrillation (HP:0001663)1.70376583
126Renal dysplasia (HP:0000110)1.69470307
127Split foot (HP:0001839)1.69178655
128Thickened helices (HP:0000391)1.67626986
129Abnormality of the renal medulla (HP:0100957)1.66158311
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65696966
131Poor eye contact (HP:0000817)1.65645130
132Abnormal EKG (HP:0003115)1.64971074
133Urinary urgency (HP:0000012)1.63599180
134Aplasia/Hypoplasia of the lens (HP:0008063)1.63252610
135Hepatoblastoma (HP:0002884)1.62773037
136Buphthalmos (HP:0000557)1.62418352
137Hyperaldosteronism (HP:0000859)1.61387167
138Increased serum pyruvate (HP:0003542)1.61194731
139Limb-girdle muscle atrophy (HP:0003797)1.60376686
140Hypoventilation (HP:0002791)1.60278924
141Postural instability (HP:0002172)1.58061796
142Myotonia (HP:0002486)1.57583745
143Fetal akinesia sequence (HP:0001989)1.56637513
144Abnormality of glycolysis (HP:0004366)1.55801145
145Rapidly progressive (HP:0003678)1.55262530
146Oculomotor apraxia (HP:0000657)1.53700073
147Arterial tortuosity (HP:0005116)1.53475462
148Anencephaly (HP:0002323)1.51875303
149Alacrima (HP:0000522)1.51319285
150Torticollis (HP:0000473)1.51312114
151Poor suck (HP:0002033)1.50985879
152Absent speech (HP:0001344)1.50975479
153Leukodystrophy (HP:0002415)1.50924035
154Renal hypoplasia (HP:0000089)1.50619206
155Decreased testicular size (HP:0008734)1.50403172
156Hammertoe (HP:0001765)1.49413992
157Abnormal neuron morphology (HP:0012757)1.49362854
158Abnormality of the motor neurons (HP:0002450)1.49362854
159Rimmed vacuoles (HP:0003805)1.48426985
160Preaxial hand polydactyly (HP:0001177)1.48194519
161Abnormality of renin-angiotensin system (HP:0000847)1.47611004
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.44251066
163Narrow forehead (HP:0000341)1.43884369
164Chronic hepatic failure (HP:0100626)1.40580430
165Atelectasis (HP:0100750)1.39089882
166Brushfield spots (HP:0001088)1.38586589
167Abnormality of the diencephalon (HP:0010662)1.38037709
168Anophthalmia (HP:0000528)1.37853410
169Shoulder girdle muscle weakness (HP:0003547)1.36656563
170Abnormality of the musculature of the pelvis (HP:0001469)1.35465787
171Abnormality of the hip-girdle musculature (HP:0001445)1.35465787
172Patchy hypopigmentation of hair (HP:0011365)1.34743656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.50246738
2NTRK33.33870132
3MAP3K92.73480426
4MARK12.62195889
5EPHB22.52253678
6NTRK12.33097520
7STK392.23362700
8BCKDK2.22791685
9MINK12.17137082
10PHKG22.16830116
11PHKG12.16830116
12NTRK22.11171357
13PRKD32.00918891
14TNIK1.98947975
15PAK61.96850109
16KSR21.95622660
17LMTK21.94308931
18MAP4K21.91674632
19WNK41.90611778
20MAP3K41.89112048
21OXSR11.79454342
22EPHA31.78690917
23CSNK1G11.77846347
24TESK11.74495386
25ARAF1.74219225
26CASK1.72416014
27KSR11.71377040
28MAP2K71.65503699
29UHMK11.62939797
30BCR1.56020902
31PAK31.50829723
32CDK51.44542522
33PNCK1.43002328
34WNK31.41143419
35TRIM281.39690573
36MAPK131.38921667
37LIMK11.37747952
38EPHB11.35096079
39CAMKK21.33321730
40EPHA21.31591144
41CDK191.30268861
42PLK21.29861736
43MAPK151.21905467
44MAP3K121.19217421
45TYRO31.15790155
46CAMK2B1.15640912
47MAP3K131.15412353
48MAP3K21.12437752
49WNK11.12011831
50NEK11.10762850
51CAMK2D1.10188705
52CAMK2A1.09165303
53MUSK1.07256123
54MET1.06804850
55CDK141.05390672
56SGK2231.04999446
57SGK4941.04999446
58NME11.04310695
59ROCK21.03854588
60CAMKK11.03363996
61PRPF4B1.02049238
62GRK50.99837246
63DAPK20.97184041
64DYRK1B0.93560199
65DDR20.92214203
66CDK180.92042921
67RIPK40.91248856
68NEK90.90970843
69CDK150.89925522
70PRKCG0.89801251
71CSNK1G20.89025257
72MAPKAPK50.87994458
73DYRK30.86433347
74OBSCN0.86049084
75MAP2K40.84868761
76RPS6KA40.84509856
77PRKCE0.83393136
78DYRK1A0.83334501
79CDK11A0.78545255
80CAMK2G0.77512297
81NEK60.76932503
82MST1R0.76420105
83FER0.74037825
84PKN10.71974110
85ERBB20.71634538
86FGR0.69682275
87STK38L0.69628352
88BMPR20.69490868
89CSNK1G30.67507738
90PTK2B0.65700778
91SRPK10.65188011
92RET0.62270481
93PINK10.60242655
94DYRK20.58828267
95PIK3CA0.58240487
96ERBB30.58075436
97CSNK1A10.57693359
98MOS0.57680109
99TIE10.56068138
100FES0.55718634
101PBK0.54276206
102ADRBK10.54227534
103RIPK10.52699725
104SCYL20.52450425
105BMPR1B0.51666953
106MAP2K10.51096749
107IRAK20.50085625
108GRK70.49705070
109CCNB10.48930279
110CAMK10.48777050
111RAF10.48767735
112MAP3K10.48376192
113CSNK1A1L0.48264428
114ROCK10.47950441
115CDK60.47479973
116DMPK0.47147528
117INSRR0.46342634
118SGK10.46101014
119AKT20.45407272
120CAMK1G0.44803187
121MARK20.44323542
122HIPK20.44133475
123FGFR20.43972230
124PRKCH0.43521162
125PIM20.42027949
126PRKACA0.41261412
127PRKCZ0.40563450
128LATS20.39286515
129PDGFRA0.38550372
130GRK10.38087309
131SRC0.34550885
132CDK30.33798290
133ERBB40.32672979
134ABL20.31521345
135PAK40.31299080
136PTK20.30923433
137PRKACG0.29841034
138PRKAA10.29731375

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97057200
2Synaptic vesicle cycle_Homo sapiens_hsa047212.67429275
3GABAergic synapse_Homo sapiens_hsa047272.55315104
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35920495
5Circadian entrainment_Homo sapiens_hsa047132.33548741
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30356042
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18592417
8Glutamatergic synapse_Homo sapiens_hsa047242.17797575
9Morphine addiction_Homo sapiens_hsa050322.14939913
10Steroid biosynthesis_Homo sapiens_hsa001002.05509522
11Insulin secretion_Homo sapiens_hsa049112.03504366
12Olfactory transduction_Homo sapiens_hsa047401.99851873
13Dopaminergic synapse_Homo sapiens_hsa047281.92529321
14Propanoate metabolism_Homo sapiens_hsa006401.92316908
15Amphetamine addiction_Homo sapiens_hsa050311.90994178
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90091056
17Oxidative phosphorylation_Homo sapiens_hsa001901.86754861
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86203296
19Long-term potentiation_Homo sapiens_hsa047201.85852725
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83799917
21Salivary secretion_Homo sapiens_hsa049701.81131725
22Cardiac muscle contraction_Homo sapiens_hsa042601.77478834
23Serotonergic synapse_Homo sapiens_hsa047261.76472941
24Cocaine addiction_Homo sapiens_hsa050301.73824640
25Gastric acid secretion_Homo sapiens_hsa049711.73250689
26Histidine metabolism_Homo sapiens_hsa003401.72648086
27Vibrio cholerae infection_Homo sapiens_hsa051101.69031002
28Collecting duct acid secretion_Homo sapiens_hsa049661.68378825
29Cholinergic synapse_Homo sapiens_hsa047251.65900879
30Fatty acid metabolism_Homo sapiens_hsa012121.64434033
31Taste transduction_Homo sapiens_hsa047421.63113133
32Parkinsons disease_Homo sapiens_hsa050121.62889659
33Arginine and proline metabolism_Homo sapiens_hsa003301.61623955
34beta-Alanine metabolism_Homo sapiens_hsa004101.58626854
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58467186
36Long-term depression_Homo sapiens_hsa047301.53563719
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52928772
38Renin secretion_Homo sapiens_hsa049241.52799979
39Alzheimers disease_Homo sapiens_hsa050101.48400609
40Fatty acid degradation_Homo sapiens_hsa000711.46660795
41Pyruvate metabolism_Homo sapiens_hsa006201.43682960
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36329489
43Fat digestion and absorption_Homo sapiens_hsa049751.35881415
44Gap junction_Homo sapiens_hsa045401.35007969
45Peroxisome_Homo sapiens_hsa041461.34361752
46PPAR signaling pathway_Homo sapiens_hsa033201.31796182
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30380116
48Phenylalanine metabolism_Homo sapiens_hsa003601.29987810
49Oxytocin signaling pathway_Homo sapiens_hsa049211.29039364
50Axon guidance_Homo sapiens_hsa043601.28253512
51Calcium signaling pathway_Homo sapiens_hsa040201.26596325
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24714186
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22187379
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22139465
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20936533
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.20323027
57Carbon metabolism_Homo sapiens_hsa012001.20178234
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15344721
59Folate biosynthesis_Homo sapiens_hsa007901.15231346
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10215568
61GnRH signaling pathway_Homo sapiens_hsa049121.09185453
62Vitamin B6 metabolism_Homo sapiens_hsa007501.08999521
63Nitrogen metabolism_Homo sapiens_hsa009101.08303308
64cAMP signaling pathway_Homo sapiens_hsa040241.07315814
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07184848
66Biosynthesis of amino acids_Homo sapiens_hsa012301.07169329
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06514932
68Melanogenesis_Homo sapiens_hsa049161.05657381
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02010763
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01631830
71Protein digestion and absorption_Homo sapiens_hsa049740.98010816
72Huntingtons disease_Homo sapiens_hsa050160.97943143
73Fructose and mannose metabolism_Homo sapiens_hsa000510.97260074
74Pancreatic secretion_Homo sapiens_hsa049720.95661441
75Dilated cardiomyopathy_Homo sapiens_hsa054140.95489472
76Chemical carcinogenesis_Homo sapiens_hsa052040.94802982
77Phototransduction_Homo sapiens_hsa047440.94788069
78Tyrosine metabolism_Homo sapiens_hsa003500.93908196
79Glutathione metabolism_Homo sapiens_hsa004800.93896794
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92212924
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92194335
82Arginine biosynthesis_Homo sapiens_hsa002200.90570318
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.90394394
84Bile secretion_Homo sapiens_hsa049760.89477987
85Estrogen signaling pathway_Homo sapiens_hsa049150.89433925
86Renin-angiotensin system_Homo sapiens_hsa046140.87320655
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86921652
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85813685
89Sulfur relay system_Homo sapiens_hsa041220.85715453
90Thyroid hormone synthesis_Homo sapiens_hsa049180.85290173
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83678870
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81962930
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81583231
94Glycerolipid metabolism_Homo sapiens_hsa005610.79652913
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78677024
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78412880
97Retinol metabolism_Homo sapiens_hsa008300.78295860
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76740653
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.75006529
100Type II diabetes mellitus_Homo sapiens_hsa049300.74565157
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73395954
102Basal cell carcinoma_Homo sapiens_hsa052170.72651899
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71304590
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.71137550
105Glioma_Homo sapiens_hsa052140.70621594
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70302219
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68661830
108ErbB signaling pathway_Homo sapiens_hsa040120.68156100
109Protein export_Homo sapiens_hsa030600.67596678
110Starch and sucrose metabolism_Homo sapiens_hsa005000.67441350
111Galactose metabolism_Homo sapiens_hsa000520.66559354
112Alcoholism_Homo sapiens_hsa050340.65702126
113Mineral absorption_Homo sapiens_hsa049780.65675108
114Dorso-ventral axis formation_Homo sapiens_hsa043200.65501448
115Fatty acid elongation_Homo sapiens_hsa000620.65501242
116Hippo signaling pathway_Homo sapiens_hsa043900.65303894
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64510639
118Sulfur metabolism_Homo sapiens_hsa009200.64051222
119Ether lipid metabolism_Homo sapiens_hsa005650.64038146
120Tryptophan metabolism_Homo sapiens_hsa003800.62970509
121Hedgehog signaling pathway_Homo sapiens_hsa043400.61326659
122Circadian rhythm_Homo sapiens_hsa047100.60611821
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60409833
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.60309078
125Type I diabetes mellitus_Homo sapiens_hsa049400.60005272
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58253355
127Metabolic pathways_Homo sapiens_hsa011000.57674497
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57194299
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.56602254
130Renal cell carcinoma_Homo sapiens_hsa052110.56519406
131Ras signaling pathway_Homo sapiens_hsa040140.53710744
132Choline metabolism in cancer_Homo sapiens_hsa052310.53628406
133Oocyte meiosis_Homo sapiens_hsa041140.52790018
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52736318
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.51939232
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.51882783
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51856188
138Wnt signaling pathway_Homo sapiens_hsa043100.51745523
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51250208
140Prion diseases_Homo sapiens_hsa050200.50052766
141Tight junction_Homo sapiens_hsa045300.49276003
142Sphingolipid metabolism_Homo sapiens_hsa006000.48999289
143Butanoate metabolism_Homo sapiens_hsa006500.46662848
144MAPK signaling pathway_Homo sapiens_hsa040100.45986502
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45060255
146Endocytosis_Homo sapiens_hsa041440.44587242
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43652206
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.40583923
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39773166
150Rap1 signaling pathway_Homo sapiens_hsa040150.39493434
151Glucagon signaling pathway_Homo sapiens_hsa049220.39078926

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