TSPAN33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound metabolic process (GO:0006778)9.45674935
2heme metabolic process (GO:0042168)9.36116217
3erythrocyte maturation (GO:0043249)8.47471329
4erythrocyte development (GO:0048821)7.44363111
5response to methylmercury (GO:0051597)6.92961355
6hemoglobin metabolic process (GO:0020027)6.70680629
7tetrapyrrole metabolic process (GO:0033013)6.33947237
8one-carbon compound transport (GO:0019755)6.29354381
9response to insecticide (GO:0017085)5.62633861
10response to lead ion (GO:0010288)5.49951029
11bicarbonate transport (GO:0015701)5.28346848
12pigment biosynthetic process (GO:0046148)5.22813524
13myeloid cell development (GO:0061515)4.83885585
14immunoglobulin mediated immune response (GO:0016064)4.77730719
15regulation of response to osmotic stress (GO:0047484)4.76701870
16regulation of T-helper 1 cell differentiation (GO:0045625)4.71214586
17erythrocyte differentiation (GO:0030218)4.66538219
18pigment metabolic process (GO:0042440)4.53646902
19neutrophil activation involved in immune response (GO:0002283)4.49417423
20positive regulation of gamma-delta T cell activation (GO:0046645)4.33012736
21negative regulation of interleukin-12 production (GO:0032695)4.26276799
22response to peptidoglycan (GO:0032494)4.17606289
23cellular response to type I interferon (GO:0071357)4.13709290
24type I interferon signaling pathway (GO:0060337)4.13709290
25response to type I interferon (GO:0034340)4.08503875
26gas transport (GO:0015669)4.08240274
27positive regulation by symbiont of host defense response (GO:0052509)4.06778319
28modulation by symbiont of host defense response (GO:0052031)4.06778319
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.06778319
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.06778319
31positive regulation by organism of defense response of other organism involved in symbiotic interact4.06778319
32modulation by symbiont of host immune response (GO:0052553)4.06778319
33granulocyte differentiation (GO:0030851)4.02622889
34interferon-gamma-mediated signaling pathway (GO:0060333)3.98273558
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.95815829
36very-low-density lipoprotein particle assembly (GO:0034379)3.93736825
37B cell mediated immunity (GO:0019724)3.93017747
38T-helper 1 type immune response (GO:0042088)3.90220108
39NIK/NF-kappaB signaling (GO:0038061)3.88174911
40macrophage activation involved in immune response (GO:0002281)3.86920446
41myeloid dendritic cell differentiation (GO:0043011)3.85649325
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.68071537
43regulation of interferon-alpha production (GO:0032647)3.64837086
44embryonic hemopoiesis (GO:0035162)3.62171099
45positive regulation of type 2 immune response (GO:0002830)3.61670269
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.55021330
47myeloid dendritic cell activation (GO:0001773)3.53078888
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52886289
49negative regulation of cell killing (GO:0031342)3.52886289
50defense response to protozoan (GO:0042832)3.43742422
51germinal center formation (GO:0002467)3.42984987
52regulation of antigen processing and presentation (GO:0002577)3.42745626
53regulation of interferon-beta biosynthetic process (GO:0045357)3.38123054
54iron ion import (GO:0097286)3.35951205
55positive regulation of interferon-alpha production (GO:0032727)3.34012515
56positive regulation of antigen processing and presentation (GO:0002579)3.33830393
57response to protozoan (GO:0001562)3.31932155
58regulation of vitamin D biosynthetic process (GO:0060556)3.30303479
59negative regulation of erythrocyte differentiation (GO:0045647)3.27223687
60response to muramyl dipeptide (GO:0032495)3.22615519
61antigen processing and presentation of endogenous antigen (GO:0019883)3.21751912
62dendritic cell differentiation (GO:0097028)3.21420342
63T cell migration (GO:0072678)3.20083463
64protein-cofactor linkage (GO:0018065)3.19785000
65positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.18127723
66platelet formation (GO:0030220)3.17798367
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17626513
68detection of bacterium (GO:0016045)3.17606211
69detection of other organism (GO:0098543)3.17428461
70cellular response to interferon-gamma (GO:0071346)3.16730328
71positive regulation of immunoglobulin mediated immune response (GO:0002891)3.16074753
72positive regulation of B cell mediated immunity (GO:0002714)3.16074753
73regulation of podosome assembly (GO:0071801)3.15173148
74regulation of interleukin-12 production (GO:0032655)3.13911959
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.13113739
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.12422236
77megakaryocyte development (GO:0035855)3.12373404
78regulation of B cell receptor signaling pathway (GO:0050855)3.11372461
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.10040515
80positive regulation of mast cell activation (GO:0033005)3.09974593
81negative regulation of cytokine production involved in immune response (GO:0002719)3.09257678
82cofactor biosynthetic process (GO:0051188)3.08766210
83regulation of T-helper 2 cell differentiation (GO:0045628)3.05440663
84response to arsenic-containing substance (GO:0046685)3.04398801
85negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.03947499
86negative regulation of myeloid cell apoptotic process (GO:0033033)3.02548548
87iron ion homeostasis (GO:0055072)3.01650655
88L-alpha-amino acid transmembrane transport (GO:1902475)3.01495047
89adenosine receptor signaling pathway (GO:0001973)3.01207078
90regulation of gamma-delta T cell activation (GO:0046643)3.00151907
91regulation of chronic inflammatory response (GO:0002676)2.98211186
92myeloid cell activation involved in immune response (GO:0002275)2.98118094
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97390929
94cellular response to thyroid hormone stimulus (GO:0097067)2.97190303
95response to host immune response (GO:0052572)2.96844820
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96844820
97granulocyte activation (GO:0036230)2.96675931
98positive regulation of T-helper cell differentiation (GO:0045624)2.95747432
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95559882
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.95286850
101B cell receptor signaling pathway (GO:0050853)2.95111295
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.94324709
103regulation of T-helper cell differentiation (GO:0045622)2.93696841
104response to interferon-gamma (GO:0034341)2.93274273
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93053699
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90172202
107water-soluble vitamin biosynthetic process (GO:0042364)2.90063434
108positive regulation of interleukin-12 production (GO:0032735)2.88760916
109positive regulation of erythrocyte differentiation (GO:0045648)2.87772732
110regulation of inflammatory response to antigenic stimulus (GO:0002861)2.86967929
111regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86398133
112regulation of mast cell degranulation (GO:0043304)2.83653690
113positive regulation of interleukin-10 production (GO:0032733)2.82642532
114regulation of interleukin-2 biosynthetic process (GO:0045076)2.82383325
115DNA replication checkpoint (GO:0000076)2.81821742
116kinetochore assembly (GO:0051382)2.80890752
117regulation of DNA endoreduplication (GO:0032875)2.79931602
118positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.79649392
119activation of MAPKKK activity (GO:0000185)2.79353946
120DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.78701629
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78686157
122regulation of mononuclear cell migration (GO:0071675)2.77994372
123B cell proliferation (GO:0042100)2.77543969
124plasma lipoprotein particle assembly (GO:0034377)2.77202482
125actin filament capping (GO:0051693)2.76751409
126regulation of interferon-gamma biosynthetic process (GO:0045072)2.76750898
127regulation of erythrocyte differentiation (GO:0045646)2.76586577
128kinetochore organization (GO:0051383)2.76515363
129centriole assembly (GO:0098534)2.72774051
130regulation of type 2 immune response (GO:0002828)2.72506041
131positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.72305553
132positive regulation of B cell differentiation (GO:0045579)2.72112680
133detection of external biotic stimulus (GO:0098581)2.71979797
134N-acetylneuraminate metabolic process (GO:0006054)2.71205810
135neutrophil activation (GO:0042119)2.69280096
136positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.69075064
137response to thyroid hormone (GO:0097066)2.69036847
138energy homeostasis (GO:0097009)2.68455481
139positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.68290402
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.67016510
141cysteine metabolic process (GO:0006534)2.66379030
142regulation of immunoglobulin secretion (GO:0051023)2.64462438
143regulation of hypersensitivity (GO:0002883)2.62840805
144import into cell (GO:0098657)2.62218487
145negative regulation of viral entry into host cell (GO:0046597)2.60285705
146regulation of cytokine secretion involved in immune response (GO:0002739)2.59982929
147receptor recycling (GO:0001881)2.59817809
148protein autoprocessing (GO:0016540)2.59203485
149NAD biosynthetic process (GO:0009435)2.58626227
150tryptophan catabolic process (GO:0006569)2.57132028
151indole-containing compound catabolic process (GO:0042436)2.57132028
152indolalkylamine catabolic process (GO:0046218)2.57132028
153microtubule depolymerization (GO:0007019)2.55879518
154drug transmembrane transport (GO:0006855)2.55681937
155meiotic chromosome segregation (GO:0045132)2.55515489
156DNA damage response, signal transduction resulting in transcription (GO:0042772)2.52358788
157superoxide anion generation (GO:0042554)2.52317180
158amine catabolic process (GO:0009310)2.52074013
159cellular biogenic amine catabolic process (GO:0042402)2.52074013
160innate immune response in mucosa (GO:0002227)2.49948569
161iron-sulfur cluster assembly (GO:0016226)2.49788410
162metallo-sulfur cluster assembly (GO:0031163)2.49788410
163regulation of RIG-I signaling pathway (GO:0039535)2.49157947
164cellular response to dexamethasone stimulus (GO:0071549)2.48129794
165DNA synthesis involved in DNA repair (GO:0000731)2.45056216
166pyridine-containing compound biosynthetic process (GO:0072525)2.42250652
167positive regulation of cellular amide metabolic process (GO:0034250)2.41073369
168proteasome assembly (GO:0043248)2.38630239
169transition metal ion homeostasis (GO:0055076)2.34708734
170deoxyribonucleotide biosynthetic process (GO:0009263)2.34255784
171protein K6-linked ubiquitination (GO:0085020)2.33448721
172lipoxygenase pathway (GO:0019372)2.32502768
173lysine catabolic process (GO:0006554)2.32177792
174lysine metabolic process (GO:0006553)2.32177792
175motile cilium assembly (GO:0044458)2.30783734
176DNA replication initiation (GO:0006270)2.30751840
177response to dexamethasone (GO:0071548)2.30237187
178tryptophan metabolic process (GO:0006568)2.30007380
179regulation of activation of Janus kinase activity (GO:0010533)2.29550640
180telomere maintenance via semi-conservative replication (GO:0032201)2.29127517
181nucleosome assembly (GO:0006334)2.28584859
182heme transport (GO:0015886)2.28062088
183response to xenobiotic stimulus (GO:0009410)2.27452059
184mitotic sister chromatid segregation (GO:0000070)2.24663144
185drug transport (GO:0015893)2.24109583
186hydrogen peroxide catabolic process (GO:0042744)2.22628214
187DNA catabolic process, exonucleolytic (GO:0000738)2.21726206
188protein-lipid complex assembly (GO:0065005)2.20222884
189regulation of nuclear cell cycle DNA replication (GO:0033262)2.20219543
190response to oxygen radical (GO:0000305)2.20096982
191organic cation transport (GO:0015695)2.18840114
192antibacterial humoral response (GO:0019731)2.17198674
193protoporphyrinogen IX metabolic process (GO:0046501)16.9247049
194protoporphyrinogen IX biosynthetic process (GO:0006782)15.6636190
195porphyrin-containing compound biosynthetic process (GO:0006779)11.8299508
196heme biosynthetic process (GO:0006783)11.6807578
197tetrapyrrole biosynthetic process (GO:0033014)10.7698474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.78948451
2E2F7_22180533_ChIP-Seq_HELA_Human6.65259991
3KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse4.99073907
4* GATA1_19941827_ChIP-Seq_MEL_Mouse4.68332195
5* GATA1_19941826_ChIP-Seq_K562_Human4.50540621
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.40482349
7TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse4.40146057
8SCL_19346495_ChIP-Seq_HPC-7_Human3.63386107
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.55962404
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07771983
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.94001785
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91190042
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.87056969
14* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.82013027
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76403478
16MYC_22102868_ChIP-Seq_BL_Human2.67738981
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.67556370
18* GATA2_19941826_ChIP-Seq_K562_Human2.59038506
19VDR_21846776_ChIP-Seq_THP-1_Human2.55475567
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44351159
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.35886903
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.30333571
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.28497207
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25189444
25VDR_24763502_ChIP-Seq_THP-1_Human2.25143588
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18856705
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18823756
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13222789
29SPI1_23547873_ChIP-Seq_NB4_Human2.09068340
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08353618
31SPI1_23127762_ChIP-Seq_K562_Human2.07312931
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.05842364
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02795063
34MAF_26560356_Chip-Seq_TH1_Human1.99928802
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.99840247
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97487469
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92411319
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91126573
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79182406
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77970604
41* LXR_22292898_ChIP-Seq_THP-1_Human1.69802148
42MYB_26560356_Chip-Seq_TH2_Human1.68147948
43TCF7_22412390_ChIP-Seq_EML_Mouse1.65441992
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.64104547
45UTX_26944678_Chip-Seq_JUKART_Human1.62255257
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61635388
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61337944
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60477517
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.57199223
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52590661
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52417045
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.52284912
53RUNX_20019798_ChIP-Seq_JUKART_Human1.50168408
54MYB_26560356_Chip-Seq_TH1_Human1.49620337
55VDR_24787735_ChIP-Seq_THP-1_Human1.48342839
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46447993
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.44696673
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.43217900
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42848817
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42848270
61MAF_26560356_Chip-Seq_TH2_Human1.42540232
62IGF1R_20145208_ChIP-Seq_DFB_Human1.41422803
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39650261
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36748721
65KDM2B_26808549_Chip-Seq_DND41_Human1.36522571
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35607092
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35198566
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32960995
69PU_27001747_Chip-Seq_BMDM_Mouse1.32124893
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30331337
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30297030
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30027782
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28657562
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27941812
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24405484
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24175622
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20811038
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20698051
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20489562
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20475102
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18407720
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17832281
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16170858
84* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15758501
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14975930
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.14796261
87GATA3_27048872_Chip-Seq_THYMUS_Human1.13406908
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12476737
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12136080
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11602036
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09289923
92VDR_23849224_ChIP-Seq_CD4+_Human1.09066903
93NCOR1_26117541_ChIP-Seq_K562_Human1.08436721
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.07233377
95BCOR_27268052_Chip-Seq_Bcells_Human1.06674857
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06441503
97BCL6_27268052_Chip-Seq_Bcells_Human1.05894975
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05440059
99TFEB_21752829_ChIP-Seq_HELA_Human1.04557850
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03788947
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03626892
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03587905
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99767947
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99286833
105* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99176278
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.98328384
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95802631
108* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94032476
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93350544
110BP1_19119308_ChIP-ChIP_Hs578T_Human0.93156548
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92160557
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.91376716
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88942427
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.87384224
115GATA3_26560356_Chip-Seq_TH2_Human0.86810888
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85944343
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85248685
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84357284
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84206435
120RUNX1_22412390_ChIP-Seq_EML_Mouse0.83969481
121ELF1_20517297_ChIP-Seq_JURKAT_Human0.80697344
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80401338
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80300296
124SPI1_20517297_ChIP-Seq_HL60_Human0.79541292
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.78876679
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77901998
127GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77037237
128RBPJ_21746931_ChIP-Seq_IB4_Human0.76723814
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76206914
130NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75980405
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.73969865
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73728884
133STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.72270008
134IRF1_19129219_ChIP-ChIP_H3396_Human0.72210103
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71857309
136E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.71677045
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.71329043
138STAT3_18555785_Chip-Seq_ESCs_Mouse0.70360021
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70232480
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.69127758
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68986804
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.68853856
143ESRRB_18555785_Chip-Seq_ESCs_Mouse0.68198844
144NMYC_18555785_Chip-Seq_ESCs_Mouse0.68152361
145HNFA_21074721_ChIP-Seq_CACO-2_Human0.67949476
146PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.67719918
147FOXP3_21729870_ChIP-Seq_TREG_Human0.66214007
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.65887863
149STAT1_20625510_ChIP-Seq_HELA_Human0.65810446
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.65281798
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.65044549
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.64379064
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63581013
154PADI4_21655091_ChIP-ChIP_MCF-7_Human0.63179227
155ETV1_20927104_ChIP-Seq_GIST48_Human0.62913556
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62701374
157RUNX1_27457419_Chip-Seq_LIVER_Mouse0.62318001
158EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.62029923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.46289656
2MP0004147_increased_porphyrin_level8.75708024
3MP0003303_peritoneal_inflammation5.08040637
4MP0002138_abnormal_hepatobiliary_system3.53441157
5MP0005058_abnormal_lysosome_morphology3.13206788
6MP0004510_myositis3.03819266
7MP0003724_increased_susceptibility_to2.94121659
8MP0006082_CNS_inflammation2.58379563
9MP0005083_abnormal_biliary_tract2.53853030
10MP0003300_gastrointestinal_ulcer2.52299322
11MP0002139_abnormal_hepatobiliary_system2.47272161
12MP0008004_abnormal_stomach_pH2.47227436
13MP0005636_abnormal_mineral_homeostasis2.44648242
14MP0009840_abnormal_foam_cell2.33739738
15MP0003111_abnormal_nucleus_morphology2.24731775
16MP0005397_hematopoietic_system_phenotyp2.12720864
17MP0001545_abnormal_hematopoietic_system2.12720864
18MP0010155_abnormal_intestine_physiology1.95253511
19MP0005451_abnormal_body_composition1.88708882
20MP0000343_altered_response_to1.87475368
21MP0001845_abnormal_inflammatory_respons1.84196100
22MP0004947_skin_inflammation1.82144765
23MP0003075_altered_response_to1.80163599
24MP0002132_abnormal_respiratory_system1.77170212
25MP0001533_abnormal_skeleton_physiology1.72172939
26MP0001835_abnormal_antigen_presentation1.68886749
27MP0009764_decreased_sensitivity_to1.64936933
28MP0003186_abnormal_redox_activity1.64229630
29MP0002876_abnormal_thyroid_physiology1.63349773
30MP0005310_abnormal_salivary_gland1.62056369
31MP0008057_abnormal_DNA_replication1.56752754
32MP0009278_abnormal_bone_marrow1.53584430
33MP0002405_respiratory_system_inflammati1.53524282
34MP0008872_abnormal_physiological_respon1.51536375
35MP0000685_abnormal_immune_system1.50146228
36MP0008260_abnormal_autophagy1.48080207
37MP0010094_abnormal_chromosome_stability1.47156513
38MP0004043_abnormal_pH_regulation1.45363373
39MP0002254_reproductive_system_inflammat1.42752494
40MP0005167_abnormal_blood-brain_barrier1.42073866
41MP0006292_abnormal_olfactory_placode1.41461130
42MP0005646_abnormal_pituitary_gland1.41323174
43MP0002998_abnormal_bone_remodeling1.39079338
44MP0003763_abnormal_thymus_physiology1.37664132
45MP0005379_endocrine/exocrine_gland_phen1.36866768
46MP0000858_altered_metastatic_potential1.35005921
47MP0003453_abnormal_keratinocyte_physiol1.34361075
48MP0002163_abnormal_gland_morphology1.34052410
49MP0005464_abnormal_platelet_physiology1.34010686
50MP0008058_abnormal_DNA_repair1.34007006
51MP0005671_abnormal_response_to1.31946351
52MP0004019_abnormal_vitamin_homeostasis1.27632704
53MP0000604_amyloidosis1.27055348
54MP0002736_abnormal_nociception_after1.24505760
55MP0003806_abnormal_nucleotide_metabolis1.22915021
56MP0005085_abnormal_gallbladder_physiolo1.20604922
57MP0003183_abnormal_peptide_metabolism1.20238104
58MP0005645_abnormal_hypothalamus_physiol1.19355852
59* MP0002398_abnormal_bone_marrow1.18900817
60MP0005166_decreased_susceptibility_to1.12463193
61MP0005360_urolithiasis1.12097961
62MP0003195_calcinosis1.10925020
63MP0006036_abnormal_mitochondrial_physio1.09541012
64MP0000465_gastrointestinal_hemorrhage1.09439712
65MP0001188_hyperpigmentation1.08730136
66MP0001764_abnormal_homeostasis1.08540222
67MP0001968_abnormal_touch/_nociception1.08193172
68MP0000015_abnormal_ear_pigmentation1.08171459
69MP0002735_abnormal_chemical_nociception1.08081000
70MP0003787_abnormal_imprinting1.06287384
71MP0003448_altered_tumor_morphology1.06192173
72MP0005387_immune_system_phenotype1.05286020
73MP0001790_abnormal_immune_system1.05286020
74MP0000490_abnormal_crypts_of1.03876802
75MP0009643_abnormal_urine_homeostasis1.00880816
76MP0001765_abnormal_ion_homeostasis1.00124981
77MP0003077_abnormal_cell_cycle0.99759537
78MP0001663_abnormal_digestive_system0.98808149
79* MP0000689_abnormal_spleen_morphology0.95565167
80MP0008874_decreased_physiological_sensi0.95354153
81MP0009785_altered_susceptibility_to0.95301671
82MP0003091_abnormal_cell_migration0.94353790
83MP0003690_abnormal_glial_cell0.94214384
84* MP0002429_abnormal_blood_cell0.92834036
85MP0009765_abnormal_xenobiotic_induced0.92411057
86* MP0002722_abnormal_immune_system0.91270855
87MP0005025_abnormal_response_to0.89097464
88MP0002396_abnormal_hematopoietic_system0.88595643
89MP0005535_abnormal_body_temperature0.86763702
90MP0002148_abnormal_hypersensitivity_rea0.85474397
91MP0003693_abnormal_embryo_hatching0.84377676
92MP0010386_abnormal_urinary_bladder0.82670016
93MP0003011_delayed_dark_adaptation0.81065587
94MP0002095_abnormal_skin_pigmentation0.80619439
95MP0008469_abnormal_protein_level0.80262695
96MP0002877_abnormal_melanocyte_morpholog0.79955454
97MP0004859_abnormal_synaptic_plasticity0.79817225
98MP0000703_abnormal_thymus_morphology0.79191729
99MP0001851_eye_inflammation0.76462542
100MP0005000_abnormal_immune_tolerance0.76112565
101MP0005332_abnormal_amino_acid0.75920554
102MP0005165_increased_susceptibility_to0.75528053
103MP0000249_abnormal_blood_vessel0.75311756
104MP0001346_abnormal_lacrimal_gland0.74839893
105MP0002332_abnormal_exercise_endurance0.74591558
106MP0001756_abnormal_urination0.74565935
107MP0004808_abnormal_hematopoietic_stem0.74560560
108MP0003252_abnormal_bile_duct0.73959969
109MP0001873_stomach_inflammation0.73856780
110MP0003879_abnormal_hair_cell0.72995839
111MP0002419_abnormal_innate_immunity0.72170031
112MP0002136_abnormal_kidney_physiology0.71615947
113MP0009333_abnormal_splenocyte_physiolog0.70608623
114MP0003191_abnormal_cellular_cholesterol0.70249628
115MP0009745_abnormal_behavioral_response0.69545386
116MP0008877_abnormal_DNA_methylation0.69105329
117MP0003718_maternal_effect0.66359015
118MP0005174_abnormal_tail_pigmentation0.66348555
119MP0003786_premature_aging0.65474344
120MP0001529_abnormal_vocalization0.65367753
121MP0000313_abnormal_cell_death0.64654434
122MP0001819_abnormal_immune_cell0.64339599
123MP0002693_abnormal_pancreas_physiology0.64235318
124MP0002723_abnormal_immune_serum0.62990842
125MP0002928_abnormal_bile_duct0.62523030
126* MP0000716_abnormal_immune_system0.62392749
127MP0005365_abnormal_bile_salt0.61972867
128MP0003436_decreased_susceptibility_to0.61778596
129MP0002420_abnormal_adaptive_immunity0.61642772
130MP0001853_heart_inflammation0.60841329
131MP0005647_abnormal_sex_gland0.60170593
132MP0000920_abnormal_myelination0.59994346
133MP0000609_abnormal_liver_physiology0.59744552
134MP0003866_abnormal_defecation0.59505607
135MP0003795_abnormal_bone_structure0.59299956
136MP0009763_increased_sensitivity_to0.59170253
137MP0002452_abnormal_antigen_presenting0.59019501
138MP0008995_early_reproductive_senescence0.58350633
139MP0005381_digestive/alimentary_phenotyp0.58100996
140MP0002166_altered_tumor_susceptibility0.57811520
141MP0009931_abnormal_skin_appearance0.56869918
142MP0003828_pulmonary_edema0.56647413
143MP0003172_abnormal_lysosome_physiology0.56426309
144MP0005666_abnormal_adipose_tissue0.56222259
145MP0000566_synostosis0.56156328
146MP0005390_skeleton_phenotype0.56009832
147MP0004142_abnormal_muscle_tone0.54838853
148MP0003880_abnormal_central_pattern0.54231772
149MP0001800_abnormal_humoral_immune0.53766136
150MP0008775_abnormal_heart_ventricle0.52071224
151MP0005584_abnormal_enzyme/coenzyme_acti0.52062718
152MP0005319_abnormal_enzyme/_coenzyme0.49835362
153MP0004883_abnormal_blood_vessel0.46692281
154MP0009642_abnormal_blood_homeostasis0.46166664

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)7.54505649
2Hypochromic microcytic anemia (HP:0004840)7.16582826
3Reticulocytosis (HP:0001923)6.43731772
4Osteomalacia (HP:0002749)5.38538117
5Cholelithiasis (HP:0001081)4.89680196
6Diaphragmatic weakness (HP:0009113)4.87060876
7Hyperbilirubinemia (HP:0002904)4.81102581
8Systemic lupus erythematosus (HP:0002725)4.68019005
9Abnormality of macrophages (HP:0004311)4.67745081
10Paralysis (HP:0003470)4.66657564
11Abnormality of glycolipid metabolism (HP:0010969)4.65581037
12Abnormality of liposaccharide metabolism (HP:0010968)4.65581037
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.65581037
14Recurrent bacterial skin infections (HP:0005406)4.58045838
15Abnormality of reticulocytes (HP:0004312)4.54531298
16Abnormal gallbladder morphology (HP:0012437)4.50874438
17Hypochromic anemia (HP:0001931)4.02494212
18Gastrointestinal stroma tumor (HP:0100723)3.97280978
19Eczematoid dermatitis (HP:0000976)3.93743359
20Dysostosis multiplex (HP:0000943)3.65278510
21Vacuolated lymphocytes (HP:0001922)3.62062939
22Mediastinal lymphadenopathy (HP:0100721)3.61320871
23Cutaneous photosensitivity (HP:0000992)3.58175422
24Petechiae (HP:0000967)3.50115874
25Spontaneous hematomas (HP:0007420)3.47769397
26Microcytic anemia (HP:0001935)3.47417932
27Optic neuritis (HP:0100653)3.43914390
28Retrobulbar optic neuritis (HP:0100654)3.43914390
29Increased cerebral lipofuscin (HP:0011813)3.42202378
30Orchitis (HP:0100796)3.31641570
31Vasculitis (HP:0002633)3.31467295
32Cholecystitis (HP:0001082)3.27616006
33Abnormal gallbladder physiology (HP:0012438)3.27616006
34Menorrhagia (HP:0000132)3.26018514
35Abnormal platelet volume (HP:0011876)3.25325998
36Meningitis (HP:0001287)3.22135756
37Insomnia (HP:0100785)3.22083013
38Stomatitis (HP:0010280)3.20213328
39Abnormality of the gallbladder (HP:0005264)3.17638780
40Loss of speech (HP:0002371)3.16653546
41Disinhibition (HP:0000734)3.14519263
42Recurrent viral infections (HP:0004429)3.13995291
43Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13250355
44Abnormal number of erythroid precursors (HP:0012131)3.12446618
45Gingival bleeding (HP:0000225)3.11948530
46Increased mean platelet volume (HP:0011877)3.10046862
47IgA deficiency (HP:0002720)3.06469431
48Chronic obstructive pulmonary disease (HP:0006510)3.06077321
49Obstructive lung disease (HP:0006536)3.06077321
50Hyponatremia (HP:0002902)3.03857619
51Recurrent gram-negative bacterial infections (HP:0005420)2.97210828
52Myositis (HP:0100614)2.97060566
53Glomerulonephritis (HP:0000099)2.93675935
54Polycythemia (HP:0001901)2.92349238
55Colitis (HP:0002583)2.90522222
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.87742409
57Chromsome breakage (HP:0040012)2.81240908
58Recurrent skin infections (HP:0001581)2.79583473
59Abnormality of sodium homeostasis (HP:0010931)2.76112324
60Short middle phalanx of the 5th finger (HP:0004220)2.71884609
61Recurrent fungal infections (HP:0002841)2.70912527
62Renal tubular acidosis (HP:0001947)2.69514997
63Encephalitis (HP:0002383)2.68981847
64Recurrent sinusitis (HP:0011108)2.62016426
65Pulmonary infiltrates (HP:0002113)2.60712499
66Abnormality of cells of the erythroid lineage (HP:0012130)2.60129139
67Agammaglobulinemia (HP:0004432)2.59016816
68Inflammation of the large intestine (HP:0002037)2.59005979
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.57873668
70Confusion (HP:0001289)2.56497107
71Prolonged bleeding time (HP:0003010)2.55211746
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53993101
73Lymphopenia (HP:0001888)2.53097514
74Gastrointestinal inflammation (HP:0004386)2.51872630
75Increased serum ferritin (HP:0003281)2.46364932
76Cellulitis (HP:0100658)2.42656497
77Mutism (HP:0002300)2.41267345
78Emphysema (HP:0002097)2.39753749
79Restrictive lung disease (HP:0002091)2.38594349
80Hepatocellular carcinoma (HP:0001402)2.38328925
81Hepatosplenomegaly (HP:0001433)2.34035054
82Birth length less than 3rd percentile (HP:0003561)2.33917261
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.33797193
84Nuclear cataract (HP:0100018)2.31939475
85Increased IgE level (HP:0003212)2.30509829
86Basal ganglia calcification (HP:0002135)2.29645087
87Axonal loss (HP:0003447)2.28645498
88Lower limb hyperreflexia (HP:0002395)2.28217138
89Keratoconjunctivitis sicca (HP:0001097)2.27656736
90Abnormality of polysaccharide metabolism (HP:0011012)2.27461114
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27461114
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27461114
93Nausea (HP:0002018)2.24253490
94Abnormality of lateral ventricle (HP:0030047)2.23182263
95Recurrent cutaneous fungal infections (HP:0011370)2.23071252
96Chronic mucocutaneous candidiasis (HP:0002728)2.23071252
97Joint swelling (HP:0001386)2.22670966
98Abnormality of iron homeostasis (HP:0011031)2.22395187
99Complement deficiency (HP:0004431)2.22372620
100Ileus (HP:0002595)2.22053338
101Arterial thrombosis (HP:0004420)2.21655810
102Abnormality of dental color (HP:0011073)2.20504880
103Autoimmune hemolytic anemia (HP:0001890)2.18409651
104Gangrene (HP:0100758)2.17899264
105Arthralgia (HP:0002829)2.16781121
106Metabolic alkalosis (HP:0200114)2.16780059
107Urinary glycosaminoglycan excretion (HP:0003541)2.16570910
108Mucopolysacchariduria (HP:0008155)2.16570910
109Hypergammaglobulinemia (HP:0010702)2.14381818
110Hemoptysis (HP:0002105)2.14189312
111Renal tubular dysfunction (HP:0000124)2.13210367
112Premature loss of primary teeth (HP:0006323)2.11072150
113Gingivitis (HP:0000230)2.10522934
114Urticaria (HP:0001025)2.10345274
115Hyperlipoproteinemia (HP:0010980)2.09587458
116Abnormality of transition element cation homeostasis (HP:0011030)2.09525515
117Epistaxis (HP:0000421)2.07814670
118Chronic otitis media (HP:0000389)2.07582456
119Keratoconjunctivitis (HP:0001096)2.06363726
120Gastrointestinal infarctions (HP:0005244)2.05706099
121Cerebral palsy (HP:0100021)2.05694313
122IgM deficiency (HP:0002850)2.05408574
123Recurrent bronchitis (HP:0002837)2.04938600
124Panhypogammaglobulinemia (HP:0003139)2.04698322
125Recurrent pneumonia (HP:0006532)2.04522999
126Progressive neurologic deterioration (HP:0002344)2.03082019
127Pulmonary embolism (HP:0002204)2.02337569
128Polyneuropathy (HP:0001271)2.02025253
129Azoospermia (HP:0000027)2.01057794
130Conjunctival telangiectasia (HP:0000524)2.00134092
131Abnormality of the heme biosynthetic pathway (HP:0010472)12.8725128
132Poikilocytosis (HP:0004447)10.3902288
133Abnormality of magnesium homeostasis (HP:0004921)1.98553379
134Hypomagnesemia (HP:0002917)1.98174642
135Hyperactive renin-angiotensin system (HP:0000841)1.93110768
136Abnormality of chloride homeostasis (HP:0011422)1.90946632
137Abnormal hair whorl (HP:0010721)1.90040394
138Rickets (HP:0002748)1.88450051
139Febrile seizures (HP:0002373)1.88034193
140Abnormality of renal excretion (HP:0011036)1.87825670
141Onycholysis (HP:0001806)1.87057042
142Pathologic fracture (HP:0002756)1.86849809
143Protruding tongue (HP:0010808)1.84045751
144Delusions (HP:0000746)1.83892281
145Polyuria (HP:0000103)1.83313387
146Duplicated collecting system (HP:0000081)1.78290243
147Nephrocalcinosis (HP:0000121)1.77461968
148Abnormality of chromosome stability (HP:0003220)1.73255328
149Abnormal urine output (HP:0012590)1.72643011
150Abnormality of pyrimidine metabolism (HP:0004353)1.71735967
151Purpura (HP:0000979)1.70978587
152Abnormal drinking behavior (HP:0030082)1.70884791
153Polydipsia (HP:0001959)1.70884791
154Cortical visual impairment (HP:0100704)1.67193919
155Pustule (HP:0200039)1.66629741
156Autoimmune thrombocytopenia (HP:0001973)1.66080897
157Tetany (HP:0001281)1.65678675
158Increased circulating renin level (HP:0000848)1.65573743
159Impaired platelet aggregation (HP:0003540)1.62623226
160Abnormal platelet function (HP:0011869)1.62623226
161Joint hemorrhage (HP:0005261)1.62355663
162Abnormality of the renal collecting system (HP:0004742)1.61619074
163Hypertensive crisis (HP:0100735)1.55277053
164Renal cortical cysts (HP:0000803)1.55063232
165Increased IgM level (HP:0003496)1.54958360
166Tubulointerstitial nephritis (HP:0001970)1.54560208
167Abnormal delayed hypersensitivity skin test (HP:0002963)1.54186310
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.53508768
169Hypokalemic alkalosis (HP:0001949)1.52784537
170Abnormal spermatogenesis (HP:0008669)1.52079132
171Abnormality of renal resorption (HP:0011038)1.51155924
172Recurrent abscess formation (HP:0002722)1.50827851
173Pallor (HP:0000980)1.50384492
174Generalized hyperpigmentation (HP:0007440)1.49840708
175Small intestinal stenosis (HP:0012848)1.47727670
176Duodenal stenosis (HP:0100867)1.47727670
177Prostate neoplasm (HP:0100787)1.47015294
178Abnormality of the preputium (HP:0100587)1.45815903
179Hyperaldosteronism (HP:0000859)1.44823208
180Alkalosis (HP:0001948)1.44236741
181Global brain atrophy (HP:0002283)1.42844202
182Metabolic acidosis (HP:0001942)1.40962867
183Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.39632101
184Neutropenia (HP:0001875)1.37726698
185Meckel diverticulum (HP:0002245)1.37274391
186Clubbing of toes (HP:0100760)1.36730572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK15.16060507
2ZAK3.66754428
3TLK13.50941332
4MAP4K13.28396799
5IRAK33.22837786
6STK42.64458073
7VRK12.30451967
8IRAK42.19889580
9MATK2.18186848
10MAP3K142.15655628
11CSF1R2.06746924
12MAP2K31.98897654
13FGR1.95185231
14BRSK11.80212428
15INSRR1.77513318
16TAOK31.73711887
17CDC71.72724430
18ERN11.71541021
19STK161.68214925
20CSK1.66782603
21BTK1.65132175
22IKBKB1.61091250
23WNK31.55652983
24DDR21.55440958
25TNIK1.55081288
26TAOK11.53244193
27IKBKE1.49441796
28MAP2K71.41602504
29TYK21.38100703
30PIM11.34269128
31ZAP701.32692297
32CASK1.30907499
33CDK121.30854959
34NME21.30809347
35EIF2AK21.25837819
36CDC42BPA1.24179844
37BMPR21.23834685
38SYK1.20897740
39BMX1.20631373
40TTK1.18715824
41NEK91.17932052
42MAP3K31.17393009
43SGK21.16439436
44MAPK111.15698983
45GRK51.15357719
46TNK21.11814958
47STK31.08763602
48ARAF1.06917285
49JAK21.06578050
50HCK1.05614757
51WNK41.05487716
52ABL21.04773596
53JAK31.03871686
54STK241.03164016
55SMG11.02123181
56KIT1.01038850
57SIK31.00879231
58CHEK21.00279510
59FGFR40.99881037
60PINK10.98840222
61RPS6KA50.98493770
62DAPK20.98105886
63TBK10.97284356
64PRPF4B0.96700051
65IRAK20.95791011
66CHUK0.94955146
67NTRK30.94884776
68SGK30.94042666
69GRK70.93806223
70MARK30.93756418
71CLK10.91912075
72TEC0.90678113
73FES0.88707621
74RIPK40.84525077
75BLK0.83386529
76SRPK10.83264456
77SGK10.82973878
78AURKA0.82383242
79MAP3K110.81735073
80SGK2230.81176879
81SGK4940.81176879
82MAPK130.80687232
83JAK10.80490442
84BRSK20.79433652
85TRIB30.78820267
86PLK40.78814094
87DYRK30.78726433
88MOS0.78709196
89IRAK10.78099165
90BRAF0.77485183
91LCK0.76099635
92PDK10.75892507
93LYN0.74960783
94PLK10.74596109
95MUSK0.73971514
96PRKAA10.73954904
97MAP3K80.72621100
98GRK60.72443184
99PBK0.72403279
100TRPM70.71993456
101STK100.71505190
102RIPK10.70564591
103DAPK30.68129691
104AURKB0.67676712
105ADRBK20.67258175
106TESK20.66357326
107PDPK10.66130208
108OXSR10.66121212
109TAOK20.65768751
110MAP2K60.63508937
111ATR0.62950082
112HIPK20.60340578
113TXK0.59945950
114BRD40.58826888
115PKN10.57120958
116NEK60.55841617
117MAP3K50.54478262
118ATM0.53679004
119SIK20.53645801
120YES10.51700888
121PRKCQ0.51488545
122GRK10.50540815
123PRKCD0.50524182
124PIM20.49811193
125MAP3K120.49673029
126ACVR1B0.49669866
127SIK10.48560344
128MELK0.47372952
129NEK20.47285038
130MAP3K100.47024797
131MAPKAPK50.46842149
132BUB10.46489823
133MST40.45622790
134MAPK120.44737839
135CHEK10.44453579
136MAPK40.43815572
137MAP3K10.43573087
138FGFR30.43155854
139MKNK20.42311865
140ITK0.40584181
141MAP3K130.39922663
142TYRO30.39209633
143DYRK1A0.38284417
144CCNB10.37680654
145CDK40.37497016
146MAPK70.35823515
147RPS6KC10.31917617
148RPS6KL10.31917617
149TGFBR20.30614587
150PIK3CG0.28650425
151CDK60.28456700
152PAK10.27815263
153FYN0.27207113
154CAMK1D0.26515956
155MAP3K90.25838416
156KSR20.24169868

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008608.26067411
2Systemic lupus erythematosus_Homo sapiens_hsa053224.31357047
3Vitamin B6 metabolism_Homo sapiens_hsa007504.17282162
4DNA replication_Homo sapiens_hsa030302.68950424
5Collecting duct acid secretion_Homo sapiens_hsa049662.54194259
6Osteoclast differentiation_Homo sapiens_hsa043802.38243310
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31973404
8B cell receptor signaling pathway_Homo sapiens_hsa046622.23480925
9ABC transporters_Homo sapiens_hsa020102.21833472
10Alcoholism_Homo sapiens_hsa050342.12771295
11Fanconi anemia pathway_Homo sapiens_hsa034602.10261388
12Primary immunodeficiency_Homo sapiens_hsa053402.07768058
13Viral myocarditis_Homo sapiens_hsa054161.92125861
14Antigen processing and presentation_Homo sapiens_hsa046121.86797053
15Hematopoietic cell lineage_Homo sapiens_hsa046401.72565939
16Homologous recombination_Homo sapiens_hsa034401.67695916
17Toxoplasmosis_Homo sapiens_hsa051451.66004509
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56346694
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55897348
20TNF signaling pathway_Homo sapiens_hsa046681.51850208
21Sulfur relay system_Homo sapiens_hsa041221.49711029
22Pertussis_Homo sapiens_hsa051331.48187679
23Cell cycle_Homo sapiens_hsa041101.46235130
24One carbon pool by folate_Homo sapiens_hsa006701.45759721
25Malaria_Homo sapiens_hsa051441.35892894
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35890148
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32881537
28Chemokine signaling pathway_Homo sapiens_hsa040621.31352870
29Nicotine addiction_Homo sapiens_hsa050331.28778082
30Phagosome_Homo sapiens_hsa041451.26946503
31African trypanosomiasis_Homo sapiens_hsa051431.24648986
32Legionellosis_Homo sapiens_hsa051341.24518582
33Measles_Homo sapiens_hsa051621.24045511
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.23853347
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21704876
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18315152
37Vitamin digestion and absorption_Homo sapiens_hsa049771.16090774
38Pyrimidine metabolism_Homo sapiens_hsa002401.15245326
39Platelet activation_Homo sapiens_hsa046111.15032774
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.14135425
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14060874
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11411146
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11388390
44Herpes simplex infection_Homo sapiens_hsa051681.11356144
45Base excision repair_Homo sapiens_hsa034101.11293274
46Graft-versus-host disease_Homo sapiens_hsa053321.07537776
47Allograft rejection_Homo sapiens_hsa053301.06568308
48Nucleotide excision repair_Homo sapiens_hsa034201.05811992
49T cell receptor signaling pathway_Homo sapiens_hsa046601.04491658
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.04005443
51Salmonella infection_Homo sapiens_hsa051321.02247821
52p53 signaling pathway_Homo sapiens_hsa041151.01264176
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00568205
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00320937
55Shigellosis_Homo sapiens_hsa051311.00272310
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99861489
57Mismatch repair_Homo sapiens_hsa034300.98164332
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.96157308
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93019111
60Epstein-Barr virus infection_Homo sapiens_hsa051690.91613014
61beta-Alanine metabolism_Homo sapiens_hsa004100.91102039
62Regulation of autophagy_Homo sapiens_hsa041400.90734907
63Apoptosis_Homo sapiens_hsa042100.90309403
64Autoimmune thyroid disease_Homo sapiens_hsa053200.88912229
65Acute myeloid leukemia_Homo sapiens_hsa052210.88494687
66Other glycan degradation_Homo sapiens_hsa005110.84388967
67Selenocompound metabolism_Homo sapiens_hsa004500.81917936
68Synaptic vesicle cycle_Homo sapiens_hsa047210.80699324
69Viral carcinogenesis_Homo sapiens_hsa052030.80533626
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80362547
71Prion diseases_Homo sapiens_hsa050200.80255149
72Peroxisome_Homo sapiens_hsa041460.77371201
73Tryptophan metabolism_Homo sapiens_hsa003800.77316443
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75884371
75Phenylalanine metabolism_Homo sapiens_hsa003600.74509500
76Type I diabetes mellitus_Homo sapiens_hsa049400.74276420
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73051803
78Glutathione metabolism_Homo sapiens_hsa004800.68125130
79Rheumatoid arthritis_Homo sapiens_hsa053230.68121558
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68033550
81Leishmaniasis_Homo sapiens_hsa051400.66214892
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65908935
83Arachidonic acid metabolism_Homo sapiens_hsa005900.65858677
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64516932
85Influenza A_Homo sapiens_hsa051640.63812229
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60712638
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.60550710
88Prolactin signaling pathway_Homo sapiens_hsa049170.60382083
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60070616
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59822080
91Bile secretion_Homo sapiens_hsa049760.57090921
92Non-homologous end-joining_Homo sapiens_hsa034500.56272192
93VEGF signaling pathway_Homo sapiens_hsa043700.55482217
94HTLV-I infection_Homo sapiens_hsa051660.54028311
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.53751096
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52985089
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.52869614
98Purine metabolism_Homo sapiens_hsa002300.52794292
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51133291
100Proteasome_Homo sapiens_hsa030500.51051376
101Staphylococcus aureus infection_Homo sapiens_hsa051500.50911539
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.49978842
103Bladder cancer_Homo sapiens_hsa052190.47579499
104Metabolic pathways_Homo sapiens_hsa011000.46724956
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.46548665
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45803698
107Pancreatic cancer_Homo sapiens_hsa052120.45745398
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45670558
109Folate biosynthesis_Homo sapiens_hsa007900.45396513
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.44892218
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44638116
112Sphingolipid metabolism_Homo sapiens_hsa006000.44444400
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44148778
114Hepatitis B_Homo sapiens_hsa051610.43774409
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43638731
116Morphine addiction_Homo sapiens_hsa050320.42859768
117Taste transduction_Homo sapiens_hsa047420.41871916
118Hepatitis C_Homo sapiens_hsa051600.41542927
119Oxidative phosphorylation_Homo sapiens_hsa001900.41142489
120Galactose metabolism_Homo sapiens_hsa000520.40509674
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39848094
122Ether lipid metabolism_Homo sapiens_hsa005650.39122699
123Chronic myeloid leukemia_Homo sapiens_hsa052200.38561299
124Complement and coagulation cascades_Homo sapiens_hsa046100.37483093
125Tuberculosis_Homo sapiens_hsa051520.35667504
126Linoleic acid metabolism_Homo sapiens_hsa005910.35643771
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35563992
128Basal transcription factors_Homo sapiens_hsa030220.35089787
129Endocytosis_Homo sapiens_hsa041440.34773652
130Amoebiasis_Homo sapiens_hsa051460.34260679
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.33980959
132Tyrosine metabolism_Homo sapiens_hsa003500.33539087
133RNA degradation_Homo sapiens_hsa030180.33218411
134Huntingtons disease_Homo sapiens_hsa050160.32800838
135Non-small cell lung cancer_Homo sapiens_hsa052230.32544788
136Parkinsons disease_Homo sapiens_hsa050120.31658986
137RNA polymerase_Homo sapiens_hsa030200.31528132
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31080626
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30103807
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29807046
141Type II diabetes mellitus_Homo sapiens_hsa049300.29010263
142GABAergic synapse_Homo sapiens_hsa047270.28135160
143Asthma_Homo sapiens_hsa053100.28098440
144Lysosome_Homo sapiens_hsa041420.27758475
145Sulfur metabolism_Homo sapiens_hsa009200.27182857
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26946273
147Mineral absorption_Homo sapiens_hsa049780.26713026
148Histidine metabolism_Homo sapiens_hsa003400.24934206
149Notch signaling pathway_Homo sapiens_hsa043300.24320802
150Renal cell carcinoma_Homo sapiens_hsa052110.23730606
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.21539809
152Renin-angiotensin system_Homo sapiens_hsa046140.21374066
153HIF-1 signaling pathway_Homo sapiens_hsa040660.20486177
154Insulin resistance_Homo sapiens_hsa049310.17456180
155Pentose phosphate pathway_Homo sapiens_hsa000300.16091082
156MAPK signaling pathway_Homo sapiens_hsa040100.14345134
157Vibrio cholerae infection_Homo sapiens_hsa051100.14255181
158PPAR signaling pathway_Homo sapiens_hsa033200.13227135
159GnRH signaling pathway_Homo sapiens_hsa049120.12477668
160Prostate cancer_Homo sapiens_hsa052150.11637953

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