TSPAN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.22624713
2barbed-end actin filament capping (GO:0051016)4.96656881
3DNA deamination (GO:0045006)4.82536410
4adhesion of symbiont to host cell (GO:0044650)4.80423242
5virion attachment to host cell (GO:0019062)4.80423242
6viral transcription (GO:0019083)4.61633770
7translational termination (GO:0006415)4.46727098
8adhesion of symbiont to host (GO:0044406)4.42557643
9platelet dense granule organization (GO:0060155)4.33918466
10definitive hemopoiesis (GO:0060216)4.19469822
11response to interferon-beta (GO:0035456)4.17667596
12translational elongation (GO:0006414)4.01825527
13response to interferon-alpha (GO:0035455)3.99690853
14endosome to melanosome transport (GO:0035646)3.97803683
15endosome to pigment granule transport (GO:0043485)3.97803683
16protein localization to endosome (GO:0036010)3.95304896
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.91378217
18skin morphogenesis (GO:0043589)3.88586201
19cell migration involved in heart development (GO:0060973)3.80830956
20protein targeting to ER (GO:0045047)3.78890497
21cotranslational protein targeting to membrane (GO:0006613)3.78531247
22ribosomal small subunit biogenesis (GO:0042274)3.78156851
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77450763
24apoptotic cell clearance (GO:0043277)3.75354622
25hyaluronan catabolic process (GO:0030214)3.73251086
26maturation of SSU-rRNA (GO:0030490)3.71094779
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70050353
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70050353
29antigen processing and presentation via MHC class Ib (GO:0002475)3.68560052
30protein localization to endoplasmic reticulum (GO:0070972)3.66751448
31positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.65727508
32protein heterotrimerization (GO:0070208)3.64541909
33endodermal cell differentiation (GO:0035987)3.62907426
34protein retention in ER lumen (GO:0006621)3.62497113
35basement membrane organization (GO:0071711)3.58474406
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58213647
37glycosphingolipid catabolic process (GO:0046479)3.52049549
38negative regulation of nitric oxide biosynthetic process (GO:0045019)3.51659850
39regulation of mononuclear cell migration (GO:0071675)3.51078622
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49790271
41low-density lipoprotein particle clearance (GO:0034383)3.45409321
42viral life cycle (GO:0019058)3.40633950
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.37447142
44stress fiber assembly (GO:0043149)3.36274281
45cell adhesion mediated by integrin (GO:0033627)3.34774070
46purine-containing compound salvage (GO:0043101)3.32781303
47COPI coating of Golgi vesicle (GO:0048205)3.32696047
48Golgi transport vesicle coating (GO:0048200)3.32696047
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32159053
50fibril organization (GO:0097435)3.29497267
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.29133411
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28996710
53positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.27616576
54extracellular fibril organization (GO:0043206)3.27570103
55positive regulation of endothelial cell apoptotic process (GO:2000353)3.27366906
56translational initiation (GO:0006413)3.25865668
57glial cell migration (GO:0008347)3.25322666
58amino sugar catabolic process (GO:0046348)3.22788661
59type B pancreatic cell proliferation (GO:0044342)3.21024230
60regulation of membrane protein ectodomain proteolysis (GO:0051043)3.19891779
61mannose metabolic process (GO:0006013)3.19815118
62cellular protein complex disassembly (GO:0043624)3.19106672
63negative regulation of smooth muscle cell migration (GO:0014912)3.17768874
64tooth mineralization (GO:0034505)3.15901297
65collagen metabolic process (GO:0032963)3.15836271
66negative regulation of erythrocyte differentiation (GO:0045647)3.13107021
67glycolipid catabolic process (GO:0019377)3.10074161
68substrate-dependent cell migration (GO:0006929)3.07804724
69UV protection (GO:0009650)3.07045717
70regulation of early endosome to late endosome transport (GO:2000641)3.05883031
71collagen catabolic process (GO:0030574)3.04649058
72oligosaccharide catabolic process (GO:0009313)3.00694036
73dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.96932650
74regulation of monocyte chemotaxis (GO:0090025)2.96804759
75purine nucleotide salvage (GO:0032261)2.94493905
76mature B cell differentiation involved in immune response (GO:0002313)2.92753040
77multicellular organismal macromolecule metabolic process (GO:0044259)2.90045428
78decidualization (GO:0046697)2.86483206
79endothelial cell chemotaxis (GO:0035767)2.86333151
80collagen fibril organization (GO:0030199)2.85471292
81positive regulation of extracellular matrix organization (GO:1903055)2.84907541
82nucleoside salvage (GO:0043174)2.84770984
83galactose catabolic process (GO:0019388)2.82842613
84negative regulation of viral entry into host cell (GO:0046597)2.82711502
85antigen processing and presentation of endogenous antigen (GO:0019883)2.81870433
86venous blood vessel morphogenesis (GO:0048845)2.79661424
87positive regulation of monocyte chemotaxis (GO:0090026)2.79362948
88valine metabolic process (GO:0006573)2.77092152
89formation of translation preinitiation complex (GO:0001731)2.76869174
90positive regulation of natural killer cell differentiation (GO:0032825)2.76855268
91vascular endothelial growth factor signaling pathway (GO:0038084)2.76615852
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76206168
93multicellular organismal catabolic process (GO:0044243)2.76105341
94extracellular matrix disassembly (GO:0022617)2.76081967
95protein complex disassembly (GO:0043241)2.75445841
96vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.75405301
97regulation of cholesterol storage (GO:0010885)2.74977220
98embryo implantation (GO:0007566)2.74667601
99secretory granule organization (GO:0033363)2.73437263
100regulation of extracellular matrix disassembly (GO:0010715)2.72974032
101multicellular organismal metabolic process (GO:0044236)2.70954454
102ribosomal large subunit biogenesis (GO:0042273)2.68676225
103ribonucleoprotein complex biogenesis (GO:0022613)2.67262407
104positive regulation of B cell differentiation (GO:0045579)2.66751494
105nucleobase biosynthetic process (GO:0046112)2.66372607
106semaphorin-plexin signaling pathway (GO:0071526)2.63903557
107endocytic recycling (GO:0032456)2.62265077
108pseudouridine synthesis (GO:0001522)2.61644391
109response to magnesium ion (GO:0032026)2.61323552
110protein targeting to membrane (GO:0006612)2.60111173
111ceramide catabolic process (GO:0046514)2.59931411
112extracellular matrix assembly (GO:0085029)2.59150098
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59016196
114IMP metabolic process (GO:0046040)2.58562092
115macromolecular complex disassembly (GO:0032984)2.54825420
116response to progesterone (GO:0032570)2.54649168
117positive regulation of respiratory burst (GO:0060267)2.54179449
118regulation of natural killer cell differentiation (GO:0032823)2.53896616
119positive regulation of cholesterol efflux (GO:0010875)2.53431438
120IMP biosynthetic process (GO:0006188)2.52347746
121cellular response to vitamin (GO:0071295)2.52186661
122purine nucleobase biosynthetic process (GO:0009113)2.52069421
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50887215
124cell-substrate junction assembly (GO:0007044)2.50856948
125telomere maintenance via semi-conservative replication (GO:0032201)2.50743429
126epithelial cell-cell adhesion (GO:0090136)2.50222172
127response to peptidoglycan (GO:0032494)2.50010635
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49948101
129membrane lipid catabolic process (GO:0046466)2.48945456
130DNA strand elongation involved in DNA replication (GO:0006271)2.46052030
131endothelial cell morphogenesis (GO:0001886)2.45831718
132translation (GO:0006412)2.45652857
133nucleotide salvage (GO:0043173)2.45519199
134cortical actin cytoskeleton organization (GO:0030866)2.45442405
135nuclear-transcribed mRNA catabolic process (GO:0000956)2.45228924
136modulation by symbiont of host cellular process (GO:0044068)2.44184647
137blood coagulation, intrinsic pathway (GO:0007597)2.44157693
138regulation of vitamin D biosynthetic process (GO:0060556)2.44146018
139peptidyl-proline hydroxylation (GO:0019511)2.43907100
140sphingolipid catabolic process (GO:0030149)2.43550640
141blood vessel maturation (GO:0001955)2.42997153
142positive regulation of chemokine biosynthetic process (GO:0045080)2.42734359
143positive regulation of fat cell differentiation (GO:0045600)2.42063911
144negative regulation of nitric-oxide synthase activity (GO:0051001)2.41795584
145regulation of apoptotic process involved in morphogenesis (GO:1902337)2.41252040
146AMP metabolic process (GO:0046033)2.41175738
147endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41164134
148positive regulation of receptor recycling (GO:0001921)2.41077348
149regulation of smooth muscle cell migration (GO:0014910)2.40315958
150folic acid metabolic process (GO:0046655)2.39681448
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.39520325
152cellular metabolic compound salvage (GO:0043094)2.38754684
153DNA strand elongation (GO:0022616)2.38499799
154positive regulation of axon extension (GO:0045773)2.38435607
155pinocytosis (GO:0006907)2.37448672
156NIK/NF-kappaB signaling (GO:0038061)2.37291884
157chondrocyte proliferation (GO:0035988)2.36394178
158protein maturation by protein folding (GO:0022417)2.35854378
159regulation of collagen metabolic process (GO:0010712)2.35235598
160purine nucleobase metabolic process (GO:0006144)2.35218399
161mRNA catabolic process (GO:0006402)2.34078305
162pteridine-containing compound biosynthetic process (GO:0042559)2.32618926
163negative regulation of biomineral tissue development (GO:0070168)2.31950106
164opsonization (GO:0008228)2.30007249
165ribosome biogenesis (GO:0042254)2.28946438
166megakaryocyte development (GO:0035855)2.28909456
167negative regulation of bone mineralization (GO:0030502)2.27748518
168L-serine metabolic process (GO:0006563)2.27260435
169negative regulation of fibrinolysis (GO:0051918)2.26742527
170Arp2/3 complex-mediated actin nucleation (GO:0034314)2.25644062
171regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.25350283
172response to thyroid hormone (GO:0097066)2.24868348
173heparin biosynthetic process (GO:0030210)2.24241953
174heparin metabolic process (GO:0030202)2.24241953
175cellular response to thyroid hormone stimulus (GO:0097067)2.24070828
176protein carboxylation (GO:0018214)2.23447479
177peptidyl-glutamic acid carboxylation (GO:0017187)2.23447479
178regulation of plasminogen activation (GO:0010755)2.21049118
179glycine metabolic process (GO:0006544)2.20694442
180RNA catabolic process (GO:0006401)2.19962980
181platelet aggregation (GO:0070527)2.19502900
182proteasome assembly (GO:0043248)2.19452030
183necroptotic process (GO:0070266)2.18965862
184immunoglobulin mediated immune response (GO:0016064)2.18446536
185serine family amino acid biosynthetic process (GO:0009070)2.18071103
186regulation of protein activation cascade (GO:2000257)2.17991080
187keratan sulfate catabolic process (GO:0042340)2.17640361
188cytokine production involved in immune response (GO:0002367)2.17009016
189respiratory chain complex IV assembly (GO:0008535)2.16704636
190negative regulation of phagocytosis (GO:0050765)2.15720927
191L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.15516797
192regulation of complement activation (GO:0030449)2.15420129
193negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.14537542
194lymph node development (GO:0048535)2.13339312
195macrophage differentiation (GO:0030225)2.12822636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66247595
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.22620671
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.21101255
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.19588111
5E2F7_22180533_ChIP-Seq_HELA_Human3.02359500
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.95886353
7SCL_19346495_ChIP-Seq_HPC-7_Human2.90038088
8LXR_22292898_ChIP-Seq_THP-1_Human2.73703251
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.49494688
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42604978
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.36768103
12* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33082586
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.32401656
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29733359
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.28960296
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19478495
17* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13715216
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12295952
19* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04692417
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.04559327
21* RXR_22158963_ChIP-Seq_LIVER_Mouse2.01814208
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01805301
23RACK7_27058665_Chip-Seq_MCF-7_Human2.01368336
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95200441
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94761098
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93926263
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88107319
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86793833
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.84744318
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84442723
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.84361925
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83986681
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82582308
34ZNF263_19887448_ChIP-Seq_K562_Human1.82395439
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80943375
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78257427
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74883434
38* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72514484
39* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72304148
40* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70297387
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70206542
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.69040835
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68646439
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68178141
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66777865
46MYC_22102868_ChIP-Seq_BL_Human1.66672647
47* SPI1_23547873_ChIP-Seq_NB4_Human1.66666192
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.66042846
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.65245789
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65056743
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.62964869
52VDR_21846776_ChIP-Seq_THP-1_Human1.61696315
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61539168
54* XRN2_22483619_ChIP-Seq_HELA_Human1.60232254
55* KDM2B_26808549_Chip-Seq_DND41_Human1.53484106
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52470515
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52039527
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52000259
59TP53_22127205_ChIP-Seq_IMR90_Human1.51187368
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50845386
61GATA1_22025678_ChIP-Seq_K562_Human1.49356757
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.47103650
63* ELK3_25401928_ChIP-Seq_HUVEC_Human1.46452063
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45688058
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45024602
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44944825
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44570062
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44375987
69* KDM2B_26808549_Chip-Seq_K562_Human1.44174162
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43257659
71DCP1A_22483619_ChIP-Seq_HELA_Human1.42637699
72* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42286680
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41889553
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.41003714
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40903051
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.40809005
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39130466
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39092191
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38838466
80* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38437861
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38405178
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38346808
83VDR_23849224_ChIP-Seq_CD4+_Human1.37554784
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35711910
85* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34925046
86* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34846404
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33487607
88SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33216965
89* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33069914
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31984493
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31462418
92ATF3_27146783_Chip-Seq_COLON_Human1.30160792
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.29716376
94* FOXP3_21729870_ChIP-Seq_TREG_Human1.29695010
95* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29057315
96GABP_19822575_ChIP-Seq_HepG2_Human1.27929361
97CLOCK_20551151_ChIP-Seq_293T_Human1.27491830
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27083194
99* TCF7_22412390_ChIP-Seq_EML_Mouse1.26946140
100* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26684902
101* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26659995
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26658183
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.25800541
104* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23321926
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.23086273
106P68_20966046_ChIP-Seq_HELA_Human1.21596732
107* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20971963
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20936250
109* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20154853
110VDR_24763502_ChIP-Seq_THP-1_Human1.20136986
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19361500
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17923632
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17911333
114* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17694873
115MAF_26560356_Chip-Seq_TH1_Human1.16203880
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15602202
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15282194
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15182475
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15037197
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14633484
121* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14171419
122* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13765171
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12751104
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12750085
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.12566235
126LXR_22158963_ChIP-Seq_LIVER_Mouse1.12175899
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11970037
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11885327
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11768675
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11547900
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10375957
132TFEB_21752829_ChIP-Seq_HELA_Human1.08227482
133* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07461987
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07070729
135DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06479445
136* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05731198
137GATA2_21666600_ChIP-Seq_HMVEC_Human1.05534566
138TTF2_22483619_ChIP-Seq_HELA_Human1.04667542
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04302785
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04242584
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03726714
142* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03636292
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03336028
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03234968
145BCOR_27268052_Chip-Seq_Bcells_Human1.01881982
146IRF8_27001747_Chip-Seq_BMDM_Mouse1.01182226
147* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00791592
148* BCL6_27268052_Chip-Seq_Bcells_Human0.99702013
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99412333
150SMC4_20622854_ChIP-Seq_HELA_Human0.99327434
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98931585
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98931475
153NCOR1_26117541_ChIP-Seq_K562_Human0.98627464
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97292372
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96665532
156* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96563685
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.96513756
158TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96243461
159SA1_22415368_ChIP-Seq_MEFs_Mouse0.96194962
160EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96144785
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95198354
162PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95164690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.84257628
2MP0005257_abnormal_intraocular_pressure3.14450849
3MP0003279_aneurysm3.08222821
4MP0010368_abnormal_lymphatic_system3.07139514
5MP0002396_abnormal_hematopoietic_system2.90798923
6MP0006054_spinal_hemorrhage2.72716275
7MP0009840_abnormal_foam_cell2.31079649
8MP0003724_increased_susceptibility_to2.30271838
9MP0004808_abnormal_hematopoietic_stem2.29934505
10MP0001545_abnormal_hematopoietic_system2.24838454
11MP0005397_hematopoietic_system_phenotyp2.24838454
12MP0004510_myositis2.13270610
13MP0003303_peritoneal_inflammation2.10245884
14MP0003705_abnormal_hypodermis_morpholog2.06898281
15MP0003172_abnormal_lysosome_physiology2.04382338
16MP0002877_abnormal_melanocyte_morpholog1.98804847
17MP0001958_emphysema1.98028185
18MP0003191_abnormal_cellular_cholesterol1.95599860
19MP0005464_abnormal_platelet_physiology1.95320386
20MP0001835_abnormal_antigen_presentation1.91114310
21MP0005503_abnormal_tendon_morphology1.83144936
22MP0006082_CNS_inflammation1.82805331
23MP0003091_abnormal_cell_migration1.79010276
24MP0009785_altered_susceptibility_to1.77805149
25MP0003806_abnormal_nucleotide_metabolis1.76972581
26MP0004147_increased_porphyrin_level1.75890573
27MP0001879_abnormal_lymphatic_vessel1.73693065
28MP0002998_abnormal_bone_remodeling1.73244464
29MP0000465_gastrointestinal_hemorrhage1.73229914
30MP0005275_abnormal_skin_tensile1.72744863
31MP0000604_amyloidosis1.71312890
32MP0004858_abnormal_nervous_system1.68521799
33MP0003300_gastrointestinal_ulcer1.67988898
34MP0001849_ear_inflammation1.67083403
35MP0005360_urolithiasis1.66061188
36MP0009379_abnormal_foot_pigmentation1.62966167
37MP0000751_myopathy1.62345023
38MP0002254_reproductive_system_inflammat1.59077586
39MP0002139_abnormal_hepatobiliary_system1.59047731
40MP0005365_abnormal_bile_salt1.58101481
41MP0003436_decreased_susceptibility_to1.57814165
42MP0009278_abnormal_bone_marrow1.57665637
43MP0003186_abnormal_redox_activity1.55584904
44MP0003075_altered_response_to1.53415158
45MP0005023_abnormal_wound_healing1.52943000
46MP0005451_abnormal_body_composition1.50075920
47MP0001853_heart_inflammation1.47710397
48MP0000343_altered_response_to1.46233327
49MP0000685_abnormal_immune_system1.44672530
50MP0005508_abnormal_skeleton_morphology1.43556075
51MP0003453_abnormal_keratinocyte_physiol1.43513053
52MP0003448_altered_tumor_morphology1.42244408
53MP0005058_abnormal_lysosome_morphology1.40645426
54MP0003329_amyloid_beta_deposits1.36864664
55MP0005595_abnormal_vascular_smooth1.36403261
56MP0005025_abnormal_response_to1.33408165
57MP0008007_abnormal_cellular_replicative1.32009414
58MP0001542_abnormal_bone_strength1.30056345
59MP0008875_abnormal_xenobiotic_pharmacok1.30024591
60MP0002419_abnormal_innate_immunity1.29757477
61MP0005085_abnormal_gallbladder_physiolo1.29697150
62MP0010030_abnormal_orbit_morphology1.28916521
63MP0001533_abnormal_skeleton_physiology1.25141151
64MP0000490_abnormal_crypts_of1.24885154
65MP0003950_abnormal_plasma_membrane1.23282845
66MP0002295_abnormal_pulmonary_circulatio1.22616187
67MP0009333_abnormal_splenocyte_physiolog1.22066308
68MP0002933_joint_inflammation1.21934336
69MP0005165_increased_susceptibility_to1.21426848
70MP0003656_abnormal_erythrocyte_physiolo1.20371872
71MP0002896_abnormal_bone_mineralization1.20064744
72MP0008260_abnormal_autophagy1.19098131
73MP0000858_altered_metastatic_potential1.18110721
74MP0009384_cardiac_valve_regurgitation1.15674554
75MP0008469_abnormal_protein_level1.14991199
76MP0005319_abnormal_enzyme/_coenzyme1.14620780
77MP0010352_gastrointestinal_tract_polyps1.14233034
78MP0010329_abnormal_lipoprotein_level1.13759310
79MP0005164_abnormal_response_to1.13112099
80MP0003566_abnormal_cell_adhesion1.12981858
81MP0002166_altered_tumor_susceptibility1.12519161
82MP0000689_abnormal_spleen_morphology1.11656886
83MP0005623_abnormal_meninges_morphology1.11186975
84MP0002148_abnormal_hypersensitivity_rea1.10173513
85MP0000598_abnormal_liver_morphology1.09888777
86MP0005671_abnormal_response_to1.09437736
87MP0004947_skin_inflammation1.08641324
88MP0002452_abnormal_antigen_presenting1.05557540
89MP0000750_abnormal_muscle_regeneration1.04958839
90MP0005174_abnormal_tail_pigmentation1.04002802
91MP0005075_abnormal_melanosome_morpholog1.03512601
92MP0005084_abnormal_gallbladder_morpholo1.03168360
93MP0002398_abnormal_bone_marrow1.02755041
94MP0009697_abnormal_copulation1.02216465
95MP0000767_abnormal_smooth_muscle1.02206799
96MP0002722_abnormal_immune_system0.99882417
97MP0005375_adipose_tissue_phenotype0.99200483
98MP0000003_abnormal_adipose_tissue0.98027918
99MP0002429_abnormal_blood_cell0.96289673
100MP0005670_abnormal_white_adipose0.95609291
101MP0005076_abnormal_cell_differentiation0.95295704
102MP0000609_abnormal_liver_physiology0.95162454
103MP0000733_abnormal_muscle_development0.94147242
104MP0001873_stomach_inflammation0.93759099
105MP0003795_abnormal_bone_structure0.93427368
106MP0002060_abnormal_skin_morphology0.93183677
107MP0002723_abnormal_immune_serum0.92928673
108MP0003943_abnormal_hepatobiliary_system0.92926803
109MP0009763_increased_sensitivity_to0.92220485
110MP0002420_abnormal_adaptive_immunity0.91802393
111MP0005390_skeleton_phenotype0.91073063
112MP0001764_abnormal_homeostasis0.90692273
113MP0000249_abnormal_blood_vessel0.90487754
114MP0001819_abnormal_immune_cell0.90393360
115MP0010155_abnormal_intestine_physiology0.89690428
116MP0001845_abnormal_inflammatory_respons0.89590953
117MP0003693_abnormal_embryo_hatching0.89539690
118MP0000013_abnormal_adipose_tissue0.89112378
119MP0001800_abnormal_humoral_immune0.87692625
120MP0005666_abnormal_adipose_tissue0.87321695
121MP0003011_delayed_dark_adaptation0.87274117
122MP0002128_abnormal_blood_circulation0.87158627
123MP0009764_decreased_sensitivity_to0.86019295
124MP0004272_abnormal_basement_membrane0.85932562
125MP0003828_pulmonary_edema0.85930157
126MP0005000_abnormal_immune_tolerance0.85851244
127MP0000716_abnormal_immune_system0.85657417
128MP0000747_muscle_weakness0.82562252
129MP0001915_intracranial_hemorrhage0.82087646
130MP0005197_abnormal_uvea_morphology0.80301398
131MP0006036_abnormal_mitochondrial_physio0.79247691
132MP0005584_abnormal_enzyme/coenzyme_acti0.79211496
133MP0003634_abnormal_glial_cell0.78471698
134MP0005332_abnormal_amino_acid0.78156409
135MP0004185_abnormal_adipocyte_glucose0.77229218
136MP0003567_abnormal_fetal_cardiomyocyte0.77052432
137MP0001243_abnormal_dermal_layer0.76828705
138MP0002095_abnormal_skin_pigmentation0.76000219
139MP0002405_respiratory_system_inflammati0.75810287
140MP0002019_abnormal_tumor_incidence0.75222951
141MP0004233_abnormal_muscle_weight0.74945872
142MP0005171_absent_coat_pigmentation0.74916731
143MP0008004_abnormal_stomach_pH0.74711542
144MP0005083_abnormal_biliary_tract0.74587679
145MP0000759_abnormal_skeletal_muscle0.74365129
146MP0002113_abnormal_skeleton_development0.73388465
147MP0001614_abnormal_blood_vessel0.66928729
148MP0002089_abnormal_postnatal_growth/wei0.66438358
149MP0005193_abnormal_anterior_eye0.65511479
150MP0004883_abnormal_blood_vessel0.62110576
151MP0003690_abnormal_glial_cell0.59173639
152MP0002108_abnormal_muscle_morphology0.58404770
153MP0000681_abnormal_thyroid_gland0.57211040

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.78286567
2Abnormality of glycolipid metabolism (HP:0010969)5.33594592
3Abnormality of liposaccharide metabolism (HP:0010968)5.33594592
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.33594592
5Thrombocytosis (HP:0001894)4.25980923
6Dysostosis multiplex (HP:0000943)4.16091679
7Premature rupture of membranes (HP:0001788)3.98476791
8Beaking of vertebral bodies (HP:0004568)3.78946129
9Vertebral compression fractures (HP:0002953)3.78922584
10Aplastic anemia (HP:0001915)3.72662949
11Abnormality of mucopolysaccharide metabolism (HP:0011020)3.53893862
12Abnormality of polysaccharide metabolism (HP:0011012)3.53893862
13Abnormality of glycosaminoglycan metabolism (HP:0004371)3.53893862
14Elevated erythrocyte sedimentation rate (HP:0003565)3.51105378
15Biconcave vertebral bodies (HP:0004586)3.44917500
16Abnormality of cells of the erythroid lineage (HP:0012130)3.36506768
17Nuclear cataract (HP:0100018)3.25296265
18Cervical subluxation (HP:0003308)3.22241489
19Abnormal number of erythroid precursors (HP:0012131)3.19359162
20Peritonitis (HP:0002586)3.17455558
21Atrophic scars (HP:0001075)2.97384780
22Axonal loss (HP:0003447)2.96302847
23Spinal rigidity (HP:0003306)2.96252455
24Myositis (HP:0100614)2.93004028
25Vascular tortuosity (HP:0004948)2.92312316
26Petechiae (HP:0000967)2.89111637
27Prolonged bleeding time (HP:0003010)2.86946622
28Nonimmune hydrops fetalis (HP:0001790)2.85306735
29Achilles tendon contracture (HP:0001771)2.82054774
30Vacuolated lymphocytes (HP:0001922)2.81305692
31Aortic aneurysm (HP:0004942)2.79621389
32Cerebral aneurysm (HP:0004944)2.77633411
33Epistaxis (HP:0000421)2.71115843
34Neurofibrillary tangles (HP:0002185)2.68918643
35Purpura (HP:0000979)2.68043076
36Fragile skin (HP:0001030)2.65579588
37Loss of speech (HP:0002371)2.64456941
38Ankle contracture (HP:0006466)2.64198382
39Reticulocytopenia (HP:0001896)2.62748212
40Increased connective tissue (HP:0009025)2.61828935
41Joint stiffness (HP:0001387)2.60002077
42Abnormality of dentin (HP:0010299)2.59637811
43Soft skin (HP:0000977)2.58778987
44Genu recurvatum (HP:0002816)2.57426906
45Arterial tortuosity (HP:0005116)2.57076450
46Abnormal platelet function (HP:0011869)2.54918558
47Impaired platelet aggregation (HP:0003540)2.54918558
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.54692510
49Reduced antithrombin III activity (HP:0001976)2.53059023
50Myocardial infarction (HP:0001658)2.52189631
51Aortic dissection (HP:0002647)2.51360446
52Abnormality of the Achilles tendon (HP:0005109)2.49805534
53Spondylolisthesis (HP:0003302)2.47002794
54Systemic lupus erythematosus (HP:0002725)2.46706804
55Type 1 muscle fiber predominance (HP:0003803)2.41727937
56Radial bowing (HP:0002986)2.41072117
57Shallow orbits (HP:0000586)2.39953559
58Short nail (HP:0001799)2.38390412
59Upper limb amyotrophy (HP:0009129)2.32926041
60Distal upper limb amyotrophy (HP:0007149)2.32926041
61Follicular hyperkeratosis (HP:0007502)2.31613900
62Thin bony cortex (HP:0002753)2.31185501
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30620934
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30620934
65Abnormality of the acetabulum (HP:0003170)2.29784158
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.29611948
67Elbow flexion contracture (HP:0002987)2.28485969
68Slender build (HP:0001533)2.26084062
69Abnormal delivery (HP:0001787)2.25769977
70Abnormality of skull ossification (HP:0002703)2.22676003
71Pallor (HP:0000980)2.21730222
72Poor head control (HP:0002421)2.18885070
73Ulnar bowing (HP:0003031)2.18046632
74Aortic regurgitation (HP:0001659)2.17994687
75Deep venous thrombosis (HP:0002625)2.17122849
76Increased variability in muscle fiber diameter (HP:0003557)2.16931014
77Mildly elevated creatine phosphokinase (HP:0008180)2.15410594
78Mitral regurgitation (HP:0001653)2.15115871
79Cerebral inclusion bodies (HP:0100314)2.14571095
80Xanthomatosis (HP:0000991)2.13253105
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.12435350
82Distal lower limb amyotrophy (HP:0008944)2.12022210
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.11201710
84Osteolytic defects of the hand bones (HP:0009699)2.11201710
85Distal lower limb muscle weakness (HP:0009053)2.11198754
86Abnormality of the intrinsic pathway (HP:0010989)2.10691881
87J-shaped sella turcica (HP:0002680)2.08297649
88Gingival bleeding (HP:0000225)2.07953660
89Decreased skull ossification (HP:0004331)2.07513662
90Abnormality of fatty-acid metabolism (HP:0004359)2.07219119
91Upper motor neuron abnormality (HP:0002127)2.05262533
92Generalized amyotrophy (HP:0003700)2.05189518
93Long toe (HP:0010511)2.04020381
94Aneurysm (HP:0002617)2.03728833
95Increased serum ferritin (HP:0003281)2.02083860
96Complement deficiency (HP:0004431)2.01446258
97Bruising susceptibility (HP:0000978)1.99501777
98Generalized aminoaciduria (HP:0002909)1.98826638
99Increased cerebral lipofuscin (HP:0011813)1.98018430
100Hyperacusis (HP:0010780)1.97756501
101Interstitial pulmonary disease (HP:0006530)1.96349451
102Dilatation of the ascending aorta (HP:0005111)1.95939454
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95557056
104Natal tooth (HP:0000695)1.95193264
105Blue sclerae (HP:0000592)1.95156631
106Menorrhagia (HP:0000132)1.94506951
107Joint laxity (HP:0001388)1.92688518
108Abnormality of the nasal mucosa (HP:0000433)1.92670016
109Coxa vara (HP:0002812)1.92183121
110Wormian bones (HP:0002645)1.91434137
111Prolonged neonatal jaundice (HP:0006579)1.90779872
112Amyloidosis (HP:0011034)1.89385881
113Abnormality of skeletal muscle fiber size (HP:0012084)1.89183722
114Type I transferrin isoform profile (HP:0003642)1.89140265
115Progressive neurologic deterioration (HP:0002344)1.88782724
116Abnormality of the common coagulation pathway (HP:0010990)1.88481847
117Spontaneous hematomas (HP:0007420)1.88389201
118Chronic otitis media (HP:0000389)1.88145617
119Hyperlipoproteinemia (HP:0010980)1.87973423
120Spontaneous abortion (HP:0005268)1.86866375
121Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86568705
122Macrocytic anemia (HP:0001972)1.86498465
123Aortic valve stenosis (HP:0001650)1.86446023
124Broad metatarsal (HP:0001783)1.85626069
125Reduced subcutaneous adipose tissue (HP:0003758)1.85029751
126IgM deficiency (HP:0002850)1.84778262
127Abnormal platelet volume (HP:0011876)1.83231459
128Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82672547
129Dicarboxylic aciduria (HP:0003215)1.82672547
130Syringomyelia (HP:0003396)1.82632551
131Spinal cord lesions (HP:0100561)1.82632551
132Turricephaly (HP:0000262)1.82335916
133Ovoid vertebral bodies (HP:0003300)1.81745220
134Neonatal short-limb short stature (HP:0008921)1.80806675
135Abnormality of complement system (HP:0005339)1.79372470
136Increased mean platelet volume (HP:0011877)1.78932695
137Ectopia lentis (HP:0001083)1.78694132
138Bladder diverticulum (HP:0000015)1.78550017
139Hand muscle atrophy (HP:0009130)1.78331875
140Congenital, generalized hypertrichosis (HP:0004540)1.78176591
141Hyperextensible skin (HP:0000974)1.78014611
142Episodic fever (HP:0001954)1.78013937
143Broad face (HP:0000283)1.76988282
144Urinary glycosaminoglycan excretion (HP:0003541)1.76820318
145Mucopolysacchariduria (HP:0008155)1.76820318
146Mitral valve prolapse (HP:0001634)1.76402067
147Abnormality of iron homeostasis (HP:0011031)1.76281150
148Orchitis (HP:0100796)1.75452530
149Bowing of the arm (HP:0006488)1.74716036
150Bowed forearm bones (HP:0003956)1.74716036
151Glomerulonephritis (HP:0000099)1.73329806
152Difficulty climbing stairs (HP:0003551)1.73016835
153Thrombophlebitis (HP:0004418)1.72745524
154Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72102865
155Abnormal cartilage morphology (HP:0002763)1.71022328
156Mitral stenosis (HP:0001718)1.70458821
157Mesangial abnormality (HP:0001966)1.70153135
158Bowel diverticulosis (HP:0005222)1.70022137
159Entropion (HP:0000621)1.69941069
160Abnormality of the peritoneum (HP:0002585)1.68817521
161Microcytic anemia (HP:0001935)1.68388022
162Asymmetric septal hypertrophy (HP:0001670)1.67778376
163Abnormality of macrophages (HP:0004311)1.66951386
164Hypertriglyceridemia (HP:0002155)1.65259939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.88867591
2ERN12.92743727
3TGFBR12.91082461
4MAP2K32.83190629
5TIE12.82788670
6TESK12.77991447
7BCKDK2.73110098
8KIT2.70434869
9KDR2.68964722
10FLT32.59804382
11WEE12.57859586
12RIPK12.39275628
13TGFBR22.36160629
14PKN22.30534488
15PIM22.25002730
16STK162.00314655
17EPHB21.96387910
18EEF2K1.93257363
19TRIB31.89749920
20LIMK11.84577325
21ACVR1B1.83603663
22RPS6KA41.82397629
23GRK71.70639442
24MAP4K11.70362687
25PRPF4B1.70253112
26TESK21.64442703
27PTK21.61835496
28ICK1.55225022
29CAMKK21.52741185
30TEC1.50619766
31TBK11.49274615
32RPS6KB21.47804614
33CDC42BPA1.44620842
34BUB11.43567982
35NTRK11.42237267
36CSF1R1.40581445
37BRSK21.40183443
38JAK31.39193148
39MAP3K111.38175889
40BTK1.36634712
41MYLK1.36112027
42EPHA21.29313183
43MAPKAPK31.25110968
44CDK81.24415739
45TYK21.24045047
46SMG11.20670371
47PAK41.20666437
48MAP3K31.18312667
49PRKD21.15276229
50BLK1.14905265
51EIF2AK11.14470692
52MUSK1.14023999
53ZAP701.13957391
54SCYL21.13873813
55LATS21.13721052
56EPHA31.13472191
57MATK1.11506092
58MAP3K141.11131254
59DYRK31.11110616
60TTN1.10995874
61LRRK21.10831748
62MAPKAPK51.06185849
63CCNB11.03633728
64RPS6KA21.02431718
65MAP3K60.98593435
66CDK190.98078578
67PRKG20.96948807
68CDK70.96874506
69MET0.94539587
70VRK10.92712546
71NEK90.92168413
72IKBKB0.90783942
73MST1R0.85153225
74PAK20.84799641
75MAP3K130.83434548
76DAPK30.82736943
77ILK0.82707564
78ABL20.82442427
79PIK3CG0.82406431
80TAOK20.81558537
81FGFR40.76686022
82TAOK10.75730318
83BMX0.73796105
84LMTK20.69790116
85EIF2AK30.68815796
86ERBB40.68323703
87TRPM70.68225000
88PDGFRB0.66238106
89MAP3K10.66139426
90MTOR0.65396517
91PIM10.63880020
92MKNK10.62126925
93MAP2K60.62024689
94BRAF0.61527565
95IKBKE0.59640968
96PDPK10.58861325
97MAP3K80.57224394
98MAPK40.56074081
99PTK60.55696039
100LYN0.55676029
101NEK20.54877326
102MAPK70.54507526
103MAPK120.53692652
104MAPK110.53477088
105IRAK30.53226019
106CSK0.52049010
107SIK10.51525930
108MOS0.49509039
109CDK60.47966647
110DDR20.47495659
111SYK0.47332959
112RPS6KA60.45170739
113CAMK1D0.43614091
114RAF10.43475996
115MAPKAPK20.43467911
116MARK20.43462226
117ARAF0.43216584
118TXK0.43041405
119GSK3A0.42586747
120CDK40.42508656
121BMPR1B0.41989743
122ZAK0.41950606
123NLK0.41685209
124CHUK0.40360609
125FGR0.39784178
126STK100.39062416
127PRKD10.38736759
128MAP3K120.38146580
129EPHB10.37319036
130RPS6KA50.34832359
131AURKB0.34212435
132STK380.34111214
133BRSK10.33246993
134PASK0.33132387
135ADRBK20.32868994
136ATR0.32834506
137LCK0.32747109
138ROCK20.32509235
139HCK0.32505125
140CDK11A0.32412987
141CDK150.31624657
142RPS6KC10.31443437
143RPS6KL10.31443437
144CLK10.31304999
145CAMKK10.31036614
146ROCK10.30797766
147PAK10.30501083
148PDGFRA0.30210743
149JAK10.30177307
150HIPK20.29579899
151CAMK2G0.29197116
152DMPK0.27366505

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.83892654
2DNA replication_Homo sapiens_hsa030302.99731439
3Folate biosynthesis_Homo sapiens_hsa007902.25082681
4Caffeine metabolism_Homo sapiens_hsa002322.03474788
5Drug metabolism - other enzymes_Homo sapiens_hsa009832.01386082
6Prion diseases_Homo sapiens_hsa050201.96498615
7Pyrimidine metabolism_Homo sapiens_hsa002401.90496999
8Mismatch repair_Homo sapiens_hsa034301.90040700
9Proteasome_Homo sapiens_hsa030501.89482925
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.89460277
11Complement and coagulation cascades_Homo sapiens_hsa046101.87419023
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79501294
13Bladder cancer_Homo sapiens_hsa052191.75405880
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74266857
15Sulfur relay system_Homo sapiens_hsa041221.71691576
16Base excision repair_Homo sapiens_hsa034101.69115732
17RNA polymerase_Homo sapiens_hsa030201.65371990
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65354115
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63932464
20TNF signaling pathway_Homo sapiens_hsa046681.59918539
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55931158
22Focal adhesion_Homo sapiens_hsa045101.55329570
23Rheumatoid arthritis_Homo sapiens_hsa053231.55234825
24Amoebiasis_Homo sapiens_hsa051461.54888301
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53869187
26Salmonella infection_Homo sapiens_hsa051321.51155901
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51002371
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.49460205
29Other glycan degradation_Homo sapiens_hsa005111.46675937
30Staphylococcus aureus infection_Homo sapiens_hsa051501.43105329
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38762152
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37672210
33One carbon pool by folate_Homo sapiens_hsa006701.36483336
34Pentose phosphate pathway_Homo sapiens_hsa000301.34481384
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34263896
36Fatty acid degradation_Homo sapiens_hsa000711.31420357
37Phagosome_Homo sapiens_hsa041451.31353710
38Nucleotide excision repair_Homo sapiens_hsa034201.30061474
39Selenocompound metabolism_Homo sapiens_hsa004501.28075681
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25143245
41Galactose metabolism_Homo sapiens_hsa000521.23639433
42Toxoplasmosis_Homo sapiens_hsa051451.23139324
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.23022199
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22051955
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20258129
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19362346
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.19150635
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17987404
49Malaria_Homo sapiens_hsa051441.16880067
50Vibrio cholerae infection_Homo sapiens_hsa051101.16252290
51N-Glycan biosynthesis_Homo sapiens_hsa005101.14521527
52Proteoglycans in cancer_Homo sapiens_hsa052051.14466316
53Biosynthesis of amino acids_Homo sapiens_hsa012301.13717602
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12652760
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08645644
56Tuberculosis_Homo sapiens_hsa051521.07391180
57Chemical carcinogenesis_Homo sapiens_hsa052041.06458846
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05815705
59Peroxisome_Homo sapiens_hsa041461.05266621
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01689834
61Homologous recombination_Homo sapiens_hsa034401.00728179
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98072601
63Glutathione metabolism_Homo sapiens_hsa004800.96471589
64Chronic myeloid leukemia_Homo sapiens_hsa052200.94965629
65Small cell lung cancer_Homo sapiens_hsa052220.94446506
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.90798495
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.90676991
68Propanoate metabolism_Homo sapiens_hsa006400.90217813
69Leishmaniasis_Homo sapiens_hsa051400.89627611
70Carbon metabolism_Homo sapiens_hsa012000.88716999
71Sphingolipid metabolism_Homo sapiens_hsa006000.88433498
72Starch and sucrose metabolism_Homo sapiens_hsa005000.88107662
73Notch signaling pathway_Homo sapiens_hsa043300.87961641
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87628747
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.87116807
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.86873078
77Tryptophan metabolism_Homo sapiens_hsa003800.86520426
78Antigen processing and presentation_Homo sapiens_hsa046120.86484992
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86065082
80Purine metabolism_Homo sapiens_hsa002300.83834875
81Spliceosome_Homo sapiens_hsa030400.83077500
82VEGF signaling pathway_Homo sapiens_hsa043700.82314557
83ECM-receptor interaction_Homo sapiens_hsa045120.81819622
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80926831
85PPAR signaling pathway_Homo sapiens_hsa033200.80677159
86Shigellosis_Homo sapiens_hsa051310.80415516
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79479517
88Legionellosis_Homo sapiens_hsa051340.78749287
89beta-Alanine metabolism_Homo sapiens_hsa004100.77664756
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77613983
91Pertussis_Homo sapiens_hsa051330.77414290
92Platelet activation_Homo sapiens_hsa046110.76866477
93Lysosome_Homo sapiens_hsa041420.76809035
94Vitamin digestion and absorption_Homo sapiens_hsa049770.75861461
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74624456
96Protein digestion and absorption_Homo sapiens_hsa049740.73960663
97Hepatitis C_Homo sapiens_hsa051600.73293097
98Influenza A_Homo sapiens_hsa051640.73087182
99p53 signaling pathway_Homo sapiens_hsa041150.72706153
100Endocytosis_Homo sapiens_hsa041440.72428345
101Herpes simplex infection_Homo sapiens_hsa051680.71606207
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71405917
103RNA transport_Homo sapiens_hsa030130.70926644
104Sulfur metabolism_Homo sapiens_hsa009200.70372516
105African trypanosomiasis_Homo sapiens_hsa051430.70097912
106Protein export_Homo sapiens_hsa030600.69994657
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68023426
108Acute myeloid leukemia_Homo sapiens_hsa052210.66055842
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.65409958
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.64655631
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.64406169
112Viral myocarditis_Homo sapiens_hsa054160.64160606
113Dilated cardiomyopathy_Homo sapiens_hsa054140.64095223
114Renin-angiotensin system_Homo sapiens_hsa046140.64088238
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63435577
116Measles_Homo sapiens_hsa051620.63350202
117Vitamin B6 metabolism_Homo sapiens_hsa007500.63137798
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62942051
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62732534
120Fatty acid metabolism_Homo sapiens_hsa012120.62624652
121Retinol metabolism_Homo sapiens_hsa008300.62055966
122Arginine biosynthesis_Homo sapiens_hsa002200.60646352
123Arginine and proline metabolism_Homo sapiens_hsa003300.60400979
124Cell cycle_Homo sapiens_hsa041100.60274015
125Hematopoietic cell lineage_Homo sapiens_hsa046400.59303847
126Pancreatic cancer_Homo sapiens_hsa052120.59080908
127HTLV-I infection_Homo sapiens_hsa051660.58980282
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58678450
129Apoptosis_Homo sapiens_hsa042100.58514359
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58103520
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57655010
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57208789
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55409373
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55164677
135RNA degradation_Homo sapiens_hsa030180.55088800
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55068672
137Fructose and mannose metabolism_Homo sapiens_hsa000510.54762333
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.54492032
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.53202765
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51670132
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51218971
142Arachidonic acid metabolism_Homo sapiens_hsa005900.50940889
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48359473
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47427188
145Thyroid cancer_Homo sapiens_hsa052160.46624396
146Pathways in cancer_Homo sapiens_hsa052000.46419153
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46024835
148Metabolic pathways_Homo sapiens_hsa011000.45049978
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44878279
150MicroRNAs in cancer_Homo sapiens_hsa052060.44873193
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44439076
152Hepatitis B_Homo sapiens_hsa051610.44161339
153Osteoclast differentiation_Homo sapiens_hsa043800.42897261
154Prolactin signaling pathway_Homo sapiens_hsa049170.41512412
155Intestinal immune network for IgA production_Homo sapiens_hsa046720.41193304
156Allograft rejection_Homo sapiens_hsa053300.39086064
157Renal cell carcinoma_Homo sapiens_hsa052110.39048053
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38630899
159Melanoma_Homo sapiens_hsa052180.37303485
160Insulin resistance_Homo sapiens_hsa049310.35149803
161HIF-1 signaling pathway_Homo sapiens_hsa040660.33596063
162Asthma_Homo sapiens_hsa053100.33234647
163Rap1 signaling pathway_Homo sapiens_hsa040150.32587075
164B cell receptor signaling pathway_Homo sapiens_hsa046620.32149803

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