TSPAN6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)3.95354889
2chromatin remodeling at centromere (GO:0031055)3.80512793
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62583333
4CENP-A containing nucleosome assembly (GO:0034080)3.62121054
5cullin deneddylation (GO:0010388)3.51529926
6otic vesicle formation (GO:0030916)3.46372957
7ATP synthesis coupled proton transport (GO:0015986)3.44222699
8energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44222699
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37442542
10glomerulus development (GO:0032835)3.33950427
11GTP biosynthetic process (GO:0006183)3.30036355
12negative regulation of axon guidance (GO:1902668)3.24808592
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.22203913
14histone exchange (GO:0043486)3.20383316
15lateral sprouting from an epithelium (GO:0060601)3.14866564
16protein deneddylation (GO:0000338)3.11774219
17cilium or flagellum-dependent cell motility (GO:0001539)3.03965282
18DNA damage response, detection of DNA damage (GO:0042769)3.00835633
19chondrocyte proliferation (GO:0035988)2.98268193
20chaperone-mediated protein transport (GO:0072321)2.97274979
21protein neddylation (GO:0045116)2.95747794
22resolution of meiotic recombination intermediates (GO:0000712)2.92070437
23regulation of mesenchymal cell apoptotic process (GO:2001053)2.86419435
24DNA replication-independent nucleosome assembly (GO:0006336)2.85787507
25DNA replication-independent nucleosome organization (GO:0034724)2.85787507
26UTP biosynthetic process (GO:0006228)2.85158136
27aldehyde catabolic process (GO:0046185)2.84676268
28DNA ligation (GO:0006266)2.82747664
29L-serine metabolic process (GO:0006563)2.81619149
30pyrimidine nucleobase catabolic process (GO:0006208)2.80976645
31negative regulation of axon extension involved in axon guidance (GO:0048843)2.79858621
32mesonephros development (GO:0001823)2.78528789
33positive regulation of synapse assembly (GO:0051965)2.78447107
34metaphase plate congression (GO:0051310)2.75478518
35lymph vessel development (GO:0001945)2.74130716
36mesenchyme morphogenesis (GO:0072132)2.74127503
37establishment of integrated proviral latency (GO:0075713)2.73497325
38kinetochore assembly (GO:0051382)2.67604778
39mitotic metaphase plate congression (GO:0007080)2.67575814
40cell differentiation involved in kidney development (GO:0061005)2.67534557
41mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.66794821
42negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.65517455
43replication fork processing (GO:0031297)2.64750850
44facial nerve structural organization (GO:0021612)2.64705472
45cholesterol biosynthetic process (GO:0006695)2.64582488
46metanephric mesenchyme development (GO:0072075)2.64506090
47peptidyl-arginine omega-N-methylation (GO:0035247)2.61575783
48DNA replication checkpoint (GO:0000076)2.61233060
49cilium organization (GO:0044782)2.61159578
50somite development (GO:0061053)2.61063234
51endocardial cushion morphogenesis (GO:0003203)2.60848399
52outer ear morphogenesis (GO:0042473)2.60772198
53epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60100061
54neuron cell-cell adhesion (GO:0007158)2.58365932
55cilium movement (GO:0003341)2.58171765
56cilium assembly (GO:0042384)2.57898229
57guanosine-containing compound biosynthetic process (GO:1901070)2.57835944
58kidney mesenchyme development (GO:0072074)2.55600441
59nonmotile primary cilium assembly (GO:0035058)2.55548326
60microtubule depolymerization (GO:0007019)2.54155242
61protein localization to kinetochore (GO:0034501)2.53553809
62sterol biosynthetic process (GO:0016126)2.52507665
63cerebral cortex radially oriented cell migration (GO:0021799)2.52264374
64ventricular cardiac muscle cell development (GO:0055015)2.51712700
65regulation of cilium movement (GO:0003352)2.51239925
66somatic hypermutation of immunoglobulin genes (GO:0016446)2.50741116
67somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50741116
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.50070681
69cell proliferation involved in metanephros development (GO:0072203)2.49885168
70histone H2A acetylation (GO:0043968)2.49575381
71purine nucleobase biosynthetic process (GO:0009113)2.49220285
72axonemal dynein complex assembly (GO:0070286)2.48467072
73cilium morphogenesis (GO:0060271)2.48201215
74regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47846890
75epithelial cell differentiation involved in kidney development (GO:0035850)2.46152137
76mesenchymal cell proliferation (GO:0010463)2.45997096
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.45892481
78urogenital system development (GO:0001655)2.45193867
79mesenchymal cell differentiation involved in kidney development (GO:0072161)2.44731064
80mesenchymal cell differentiation involved in renal system development (GO:2001012)2.44731064
81regulation of axon guidance (GO:1902667)2.42964971
82cell proliferation involved in kidney development (GO:0072111)2.42937479
83peptidyl-arginine methylation (GO:0018216)2.42740258
84peptidyl-arginine N-methylation (GO:0035246)2.42740258
85proteasome assembly (GO:0043248)2.40179734
86kidney morphogenesis (GO:0060993)2.40075579
87water-soluble vitamin biosynthetic process (GO:0042364)2.38975533
88short-term memory (GO:0007614)2.38799013
89histone arginine methylation (GO:0034969)2.38357857
90intraciliary transport (GO:0042073)2.38249060
91neuron recognition (GO:0008038)2.36718495
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36593968
93UTP metabolic process (GO:0046051)2.36575131
94axonal fasciculation (GO:0007413)2.36280019
95epithelial cilium movement (GO:0003351)2.35950802
96artery development (GO:0060840)2.35948329
97startle response (GO:0001964)2.34510063
98cochlea morphogenesis (GO:0090103)2.34446089
99negative regulation of DNA recombination (GO:0045910)2.34338027
100establishment of tissue polarity (GO:0007164)2.34302588
101establishment of planar polarity (GO:0001736)2.34302588
102cranial nerve morphogenesis (GO:0021602)2.33450580
103regulation of mesoderm development (GO:2000380)2.33366170
104CTP metabolic process (GO:0046036)2.33360614
105CTP biosynthetic process (GO:0006241)2.33360614
106axoneme assembly (GO:0035082)2.31925448
107neural crest cell development (GO:0014032)2.31753775
108response to nitrosative stress (GO:0051409)2.31259485
109serine family amino acid catabolic process (GO:0009071)2.31218257
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.30503766
111axon extension involved in axon guidance (GO:0048846)2.30151904
112neuron projection extension involved in neuron projection guidance (GO:1902284)2.30151904
113heart valve formation (GO:0003188)2.29983650
114atrial septum morphogenesis (GO:0060413)2.29905412
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.29858011
116spindle checkpoint (GO:0031577)2.29200623
117sympathetic nervous system development (GO:0048485)2.28824897
118branched-chain amino acid catabolic process (GO:0009083)2.28622811
119synapsis (GO:0007129)2.28556621
120negative regulation of stem cell proliferation (GO:2000647)2.27967730
121embryonic digestive tract morphogenesis (GO:0048557)2.27510537
122DNA double-strand break processing (GO:0000729)2.27198191
123respiratory chain complex IV assembly (GO:0008535)2.26014142
124regulation of helicase activity (GO:0051095)2.26013131
125anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.25398376
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.25388621
127notochord development (GO:0030903)2.25235254
128viral mRNA export from host cell nucleus (GO:0046784)2.25110625
129centriole replication (GO:0007099)2.25041352
130spliceosomal snRNP assembly (GO:0000387)2.24876724
131regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.24356368
132regulation of mitotic spindle checkpoint (GO:1903504)2.24356368
133negative regulation of ligase activity (GO:0051352)2.24354976
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.24354976
135cell proliferation in forebrain (GO:0021846)2.23850995
136nucleobase biosynthetic process (GO:0046112)2.23495861
137pattern specification involved in kidney development (GO:0061004)2.23430223
138lysine catabolic process (GO:0006554)2.23385004
139lysine metabolic process (GO:0006553)2.23385004
140positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.23018161
141proximal/distal pattern formation (GO:0009954)2.22879659
142regulation of synapse assembly (GO:0051963)2.22819850
143radial glial cell differentiation (GO:0060019)2.22787826
144left/right pattern formation (GO:0060972)2.22667547
145RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.22388002
146tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.22388002
147mesenchymal to epithelial transition (GO:0060231)2.22257080
148genitalia morphogenesis (GO:0035112)2.21878552
149paraxial mesoderm development (GO:0048339)2.21859261
150dendritic spine morphogenesis (GO:0060997)2.21711824
151female gonad development (GO:0008585)2.21619475
152exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.21342247
153lung-associated mesenchyme development (GO:0060484)2.20959138
154mesenchymal cell development (GO:0014031)2.20955909
155smoothened signaling pathway (GO:0007224)2.20822780
156pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.20413659
157cranial nerve structural organization (GO:0021604)2.20323506
158ribosomal small subunit biogenesis (GO:0042274)2.19564612
159regulation of centriole replication (GO:0046599)2.19411722
160kinetochore organization (GO:0051383)2.19344808
161mitotic spindle checkpoint (GO:0071174)2.18861450
162glycine metabolic process (GO:0006544)2.17646123
163regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.17361837
164dorsal/ventral axis specification (GO:0009950)2.16136901
165DNA strand renaturation (GO:0000733)2.15784312
166double-strand break repair via nonhomologous end joining (GO:0006303)2.15683339
167non-recombinational repair (GO:0000726)2.15683339
168retinal ganglion cell axon guidance (GO:0031290)2.14921175
169left/right axis specification (GO:0070986)2.14307978
170mitochondrial respiratory chain complex assembly (GO:0033108)2.14239486
171regulation of mitochondrial translation (GO:0070129)2.14178180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.62234787
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.38324575
3EZH2_22144423_ChIP-Seq_EOC_Human3.36290111
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.51597947
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.51114024
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32603160
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.31136455
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28367828
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28095106
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.27899776
11E2F7_22180533_ChIP-Seq_HELA_Human2.21600842
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13835531
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13408062
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12474120
15FUS_26573619_Chip-Seq_HEK293_Human2.11285811
16POU5F1_16153702_ChIP-ChIP_HESCs_Human2.11048337
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01525062
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.96796920
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94089802
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92848521
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.92634592
22GBX2_23144817_ChIP-Seq_PC3_Human1.92336985
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92272904
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91709182
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86718571
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83458020
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83458020
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81362305
29ZNF274_21170338_ChIP-Seq_K562_Hela1.80402472
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.77634392
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77291765
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76921384
33RNF2_27304074_Chip-Seq_NSC_Mouse1.74030254
34TAF15_26573619_Chip-Seq_HEK293_Human1.73646272
35AR_21909140_ChIP-Seq_LNCAP_Human1.71513300
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71408797
37EWS_26573619_Chip-Seq_HEK293_Human1.70893992
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70426609
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68230072
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.63765787
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62699734
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.61300279
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60814068
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.59114017
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58272522
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53896481
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52901250
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52700603
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.51670630
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50862673
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.48472111
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46991822
53MYC_18940864_ChIP-ChIP_HL60_Human1.43280814
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43126307
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.42865608
56P300_19829295_ChIP-Seq_ESCs_Human1.42755989
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.42725181
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41746580
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39966901
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39158472
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38623807
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.38208550
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35801215
64IGF1R_20145208_ChIP-Seq_DFB_Human1.34925901
65ELK1_19687146_ChIP-ChIP_HELA_Human1.34795484
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33993205
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33858788
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32827888
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31218726
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.30735175
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29141718
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26949380
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25919827
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25146403
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24799162
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23431554
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.21908054
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.21603389
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21412461
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20794764
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19559442
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19271628
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16878456
84SOX9_26525672_Chip-Seq_HEART_Mouse1.16452688
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15070982
86TTF2_22483619_ChIP-Seq_HELA_Human1.14479839
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.14024132
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12793484
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11657450
90VDR_23849224_ChIP-Seq_CD4+_Human1.11217467
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11014514
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10909227
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.10877025
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10746412
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10708974
96AR_21572438_ChIP-Seq_LNCaP_Human1.10671434
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09967186
98VDR_22108803_ChIP-Seq_LS180_Human1.09609681
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07366645
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07069735
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06719574
102YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06658741
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05932626
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05521956
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05213426
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04975292
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04602922
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.04483052
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03488064
110MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02641940
111ER_23166858_ChIP-Seq_MCF-7_Human1.01792182
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00986212
113FOXP3_21729870_ChIP-Seq_TREG_Human1.00507462
114TCF4_22108803_ChIP-Seq_LS180_Human1.00342027
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99771482
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98949311
117MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98634028
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98441533
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96497370
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.96318428
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.96160319
122E2F1_21310950_ChIP-Seq_MCF-7_Human0.95790991
123TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95361170
124SMAD4_21799915_ChIP-Seq_A2780_Human0.94585767
125TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94466100
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94410993
127XRN2_22483619_ChIP-Seq_HELA_Human0.94408643
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93945343
129MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93798196
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93188216
131SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92948979
132JUN_21703547_ChIP-Seq_K562_Human0.92475181
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92464553
134* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92282391
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92127250
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91899976
137IRF1_19129219_ChIP-ChIP_H3396_Human0.91451668
138CBP_20019798_ChIP-Seq_JUKART_Human0.90648025
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90648025
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90243596
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.89955044
142THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89480332
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.89251396
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87993452
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.87974248
146TP53_18474530_ChIP-ChIP_U2OS_Human0.87602683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.84695877
2MP0010030_abnormal_orbit_morphology3.05423898
3MP0005503_abnormal_tendon_morphology2.86798845
4MP0003121_genomic_imprinting2.71794987
5MP0009379_abnormal_foot_pigmentation2.52529544
6MP0000537_abnormal_urethra_morphology2.49812325
7MP0003385_abnormal_body_wall2.48653601
8MP0003878_abnormal_ear_physiology2.45144514
9MP0005377_hearing/vestibular/ear_phenot2.45144514
10MP0009250_abnormal_appendicular_skeleto2.28994949
11MP0000049_abnormal_middle_ear2.26752486
12MP0003123_paternal_imprinting2.16031151
13MP0002938_white_spotting2.13179231
14MP0003942_abnormal_urinary_system2.08414680
15MP0002282_abnormal_trachea_morphology2.04250276
16MP0002102_abnormal_ear_morphology2.02323296
17MP0002249_abnormal_larynx_morphology1.94967006
18MP0000778_abnormal_nervous_system1.93611741
19MP0000566_synostosis1.88291064
20MP0005423_abnormal_somatic_nervous1.85891078
21MP0003880_abnormal_central_pattern1.81798137
22MP0006276_abnormal_autonomic_nervous1.81493204
23MP0001879_abnormal_lymphatic_vessel1.74683059
24MP0003937_abnormal_limbs/digits/tail_de1.73798161
25MP0004272_abnormal_basement_membrane1.73055449
26MP0003315_abnormal_perineum_morphology1.68903558
27MP0003693_abnormal_embryo_hatching1.67427682
28MP0005394_taste/olfaction_phenotype1.65958284
29MP0005499_abnormal_olfactory_system1.65958284
30MP0010094_abnormal_chromosome_stability1.64220594
31MP0006072_abnormal_retinal_apoptosis1.61427238
32MP0009053_abnormal_anal_canal1.58517834
33MP0004133_heterotaxia1.57391693
34MP0003755_abnormal_palate_morphology1.56887290
35MP0004134_abnormal_chest_morphology1.56194738
36MP0004957_abnormal_blastocyst_morpholog1.55256036
37MP0001529_abnormal_vocalization1.52226527
38MP0008438_abnormal_cutaneous_collagen1.52089355
39MP0003787_abnormal_imprinting1.47425271
40MP0003283_abnormal_digestive_organ1.43057161
41MP0003938_abnormal_ear_development1.42780821
42MP0008932_abnormal_embryonic_tissue1.42693621
43MP0010368_abnormal_lymphatic_system1.42390859
44MP0003119_abnormal_digestive_system1.41974098
45MP0000534_abnormal_ureter_morphology1.39118138
46MP0001485_abnormal_pinna_reflex1.39011370
47MP0005248_abnormal_Harderian_gland1.38867523
48MP0001188_hyperpigmentation1.36268578
49MP0003941_abnormal_skin_development1.33699178
50MP0002932_abnormal_joint_morphology1.33028931
51MP0001984_abnormal_olfaction1.32386322
52MP0003718_maternal_effect1.32075391
53MP0002116_abnormal_craniofacial_bone1.31139170
54MP0005391_vision/eye_phenotype1.25545125
55MP0006292_abnormal_olfactory_placode1.25431847
56MP0003890_abnormal_embryonic-extraembry1.25359726
57MP0000631_abnormal_neuroendocrine_gland1.24726931
58MP0002233_abnormal_nose_morphology1.24136864
59MP0002092_abnormal_eye_morphology1.23485268
60MP0003115_abnormal_respiratory_system1.22506038
61MP0005275_abnormal_skin_tensile1.22024740
62MP0008875_abnormal_xenobiotic_pharmacok1.21920462
63MP0005623_abnormal_meninges_morphology1.21910025
64MP0005253_abnormal_eye_physiology1.20285120
65MP0000762_abnormal_tongue_morphology1.20054417
66MP0002751_abnormal_autonomic_nervous1.18692262
67MP0005171_absent_coat_pigmentation1.17860124
68MP0003195_calcinosis1.16779221
69MP0003861_abnormal_nervous_system1.15088207
70MP0003011_delayed_dark_adaptation1.14357717
71MP0005508_abnormal_skeleton_morphology1.13217991
72MP0002184_abnormal_innervation1.12876925
73MP0000516_abnormal_urinary_system1.11699020
74MP0005367_renal/urinary_system_phenotyp1.11699020
75MP0002177_abnormal_outer_ear1.08644042
76MP0002084_abnormal_developmental_patter1.07144037
77MP0001905_abnormal_dopamine_level1.06694661
78MP0005085_abnormal_gallbladder_physiolo1.05685884
79MP0001346_abnormal_lacrimal_gland1.05209091
80MP0003077_abnormal_cell_cycle1.05206910
81MP0003935_abnormal_craniofacial_develop1.04625174
82MP0001286_abnormal_eye_development1.04249442
83MP0000579_abnormal_nail_morphology1.03837705
84MP0008877_abnormal_DNA_methylation1.03379043
85MP0008789_abnormal_olfactory_epithelium1.00782223
86MP0000647_abnormal_sebaceous_gland1.00317887
87MP0001293_anophthalmia0.98518310
88MP0002109_abnormal_limb_morphology0.97616248
89MP0002127_abnormal_cardiovascular_syste0.97366527
90MP0000428_abnormal_craniofacial_morphol0.97281579
91MP0002114_abnormal_axial_skeleton0.97140787
92MP0005551_abnormal_eye_electrophysiolog0.96528638
93MP0002108_abnormal_muscle_morphology0.95258512
94MP0003111_abnormal_nucleus_morphology0.94564290
95MP0005257_abnormal_intraocular_pressure0.94100014
96MP0005409_darkened_coat_color0.93844333
97MP0000026_abnormal_inner_ear0.93315204
98MP0002111_abnormal_tail_morphology0.92256147
99MP0001324_abnormal_eye_pigmentation0.91544062
100MP0003136_yellow_coat_color0.90733484
101MP0002081_perinatal_lethality0.89453086
102MP0000163_abnormal_cartilage_morphology0.88383275
103MP0009697_abnormal_copulation0.87143382
104MP0003186_abnormal_redox_activity0.86863387
105MP0002557_abnormal_social/conspecific_i0.85460317
106MP0001929_abnormal_gametogenesis0.85274104
107MP0009384_cardiac_valve_regurgitation0.84800102
108MP0006054_spinal_hemorrhage0.84038025
109MP0002152_abnormal_brain_morphology0.83105521
110MP0000432_abnormal_head_morphology0.81754757
111MP0002210_abnormal_sex_determination0.81482930
112MP0005195_abnormal_posterior_eye0.81052274
113MP0005187_abnormal_penis_morphology0.80613455
114MP0002090_abnormal_vision0.79878011
115MP0000653_abnormal_sex_gland0.79842277
116MP0009672_abnormal_birth_weight0.79213076
117MP0002254_reproductive_system_inflammat0.79013032
118MP0008007_abnormal_cellular_replicative0.78497497
119MP0003279_aneurysm0.77925438
120MP0001145_abnormal_male_reproductive0.77568146
121MP0002697_abnormal_eye_size0.77525449
122MP0001299_abnormal_eye_distance/0.77099081
123MP0000383_abnormal_hair_follicle0.77035377
124MP0005408_hypopigmentation0.76416902
125MP0001177_atelectasis0.76308253
126MP0003567_abnormal_fetal_cardiomyocyte0.76150914
127MP0005084_abnormal_gallbladder_morpholo0.76069271
128MP0000462_abnormal_digestive_system0.75704506
129MP0001968_abnormal_touch/_nociception0.75015807
130MP0002734_abnormal_mechanical_nocicepti0.74102087
131MP0002736_abnormal_nociception_after0.73503182
132MP0002160_abnormal_reproductive_system0.73443984
133MP0002752_abnormal_somatic_nervous0.73017513
134MP0002653_abnormal_ependyma_morphology0.72501040
135MP0008058_abnormal_DNA_repair0.72366842
136MP0002234_abnormal_pharynx_morphology0.72189817
137MP0002085_abnormal_embryonic_tissue0.71745038
138MP0002089_abnormal_postnatal_growth/wei0.71314458
139MP0000538_abnormal_urinary_bladder0.69768734
140MP0002115_abnormal_skeleton_extremities0.68738903
141MP0001340_abnormal_eyelid_morphology0.67846050

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.36464148
2Hepatoblastoma (HP:0002884)3.12841724
3Hyperglycinemia (HP:0002154)3.09958873
4Pancreatic cysts (HP:0001737)2.98221209
5Abnormality of the labia minora (HP:0012880)2.85114880
6Abnormality of dentin (HP:0010299)2.80770871
7Abnormality of midbrain morphology (HP:0002418)2.72249725
8Molar tooth sign on MRI (HP:0002419)2.72249725
9Fibular hypoplasia (HP:0003038)2.65462162
10Nephronophthisis (HP:0000090)2.63599249
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55276271
12Postaxial foot polydactyly (HP:0001830)2.54830377
13Abnormal ciliary motility (HP:0012262)2.53967549
14Aplasia/Hypoplasia of the tongue (HP:0010295)2.53467816
15Myelomeningocele (HP:0002475)2.52309323
16Adrenal hypoplasia (HP:0000835)2.52252016
17Abnormal respiratory motile cilium morphology (HP:0005938)2.51772998
18Abnormal respiratory epithelium morphology (HP:0012253)2.51772998
19Abnormal respiratory motile cilium physiology (HP:0012261)2.51736017
20Abnormality of glycolysis (HP:0004366)2.49302283
21Increased serum pyruvate (HP:0003542)2.49302283
22Septo-optic dysplasia (HP:0100842)2.47097942
23Supernumerary spleens (HP:0009799)2.41278694
24High anterior hairline (HP:0009890)2.39934098
25Embryonal renal neoplasm (HP:0011794)2.36050396
26Morphological abnormality of the middle ear (HP:0008609)2.35414385
27Abnormality of serine family amino acid metabolism (HP:0010894)2.34268009
28Abnormality of glycine metabolism (HP:0010895)2.34268009
29Asymmetry of the thorax (HP:0001555)2.34228792
30Hyperglycinuria (HP:0003108)2.33871094
31Chronic bronchitis (HP:0004469)2.33541114
32Short 4th metacarpal (HP:0010044)2.31886689
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31886689
34Hypoplastic left heart (HP:0004383)2.30381960
35Acute necrotizing encephalopathy (HP:0006965)2.29881032
36Chronic hepatic failure (HP:0100626)2.29669219
37Nephroblastoma (Wilms tumor) (HP:0002667)2.27984833
38Aplasia/Hypoplasia of the fibula (HP:0006492)2.27174421
39Abnormal umbilical cord blood vessels (HP:0011403)2.26569653
40Single umbilical artery (HP:0001195)2.26569653
41Abnormality of the fetal cardiovascular system (HP:0010948)2.26569653
42Meckel diverticulum (HP:0002245)2.24347620
43Cystic liver disease (HP:0006706)2.23587570
44Colon cancer (HP:0003003)2.22858052
45Anophthalmia (HP:0000528)2.22657351
46Acute encephalopathy (HP:0006846)2.21148823
47True hermaphroditism (HP:0010459)2.18523005
48Limb dystonia (HP:0002451)2.17712505
49Postaxial hand polydactyly (HP:0001162)2.16062996
50Neonatal short-limb short stature (HP:0008921)2.16062933
51Abnormality of the ileum (HP:0001549)2.14680654
52Absent/shortened dynein arms (HP:0200106)2.14650027
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.14650027
54Male pseudohermaphroditism (HP:0000037)2.13390005
55Abnormal lung lobation (HP:0002101)2.12435644
56Abnormality of the renal medulla (HP:0100957)2.10933219
57Triphalangeal thumb (HP:0001199)2.09925654
58Diastasis recti (HP:0001540)2.09704668
59Occipital encephalocele (HP:0002085)2.06716384
60Abnormality of serum amino acid levels (HP:0003112)2.04792610
61Stenosis of the external auditory canal (HP:0000402)2.02989403
62Gait imbalance (HP:0002141)2.02143533
63Absent radius (HP:0003974)2.01102636
64Bifid tongue (HP:0010297)2.01024986
65Median cleft lip (HP:0000161)1.98789223
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.97671436
67Esophageal atresia (HP:0002032)1.96372516
68Lissencephaly (HP:0001339)1.95959904
69Medial flaring of the eyebrow (HP:0010747)1.95868270
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.95218470
71Absent forearm bone (HP:0003953)1.93179723
72Aplasia involving forearm bones (HP:0009822)1.93179723
73Fibular aplasia (HP:0002990)1.92915983
74Progressive macrocephaly (HP:0004481)1.92663750
75Anencephaly (HP:0002323)1.91413434
76Hypoplastic heart (HP:0001961)1.91277334
77Abnormal mitochondria in muscle tissue (HP:0008316)1.90962479
78Rhinitis (HP:0012384)1.90845775
79Bilateral microphthalmos (HP:0007633)1.89434573
80Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89195642
81Tracheomalacia (HP:0002779)1.88727721
82Short tibia (HP:0005736)1.88533405
83Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87604538
84Hypoplasia of the brainstem (HP:0002365)1.87604538
85Abnormality of the middle phalanges of the toes (HP:0010183)1.85270325
86Transposition of the great arteries (HP:0001669)1.83212233
87Abnormal connection of the cardiac segments (HP:0011545)1.83212233
88Abnormal ventriculo-arterial connection (HP:0011563)1.83212233
89Tubulointerstitial nephritis (HP:0001970)1.82469110
90Hypoplastic pelvis (HP:0008839)1.81852304
91Broad foot (HP:0001769)1.80105325
92Preaxial hand polydactyly (HP:0001177)1.79439177
93Congenital primary aphakia (HP:0007707)1.79261709
94Congenital hepatic fibrosis (HP:0002612)1.79150189
95Abnormality of the phalanges of the hallux (HP:0010057)1.79137949
96Vaginal atresia (HP:0000148)1.78723890
97Abnormality of incisor morphology (HP:0011063)1.78667495
98Intestinal atresia (HP:0011100)1.77494547
99Abnormality of methionine metabolism (HP:0010901)1.76364459
100Gastrointestinal atresia (HP:0002589)1.76317942
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75219972
102Increased hepatocellular lipid droplets (HP:0006565)1.74976692
103Abnormal biliary tract physiology (HP:0012439)1.74389065
104Bile duct proliferation (HP:0001408)1.74389065
105Nephrogenic diabetes insipidus (HP:0009806)1.74338118
106Genital tract atresia (HP:0001827)1.74286116
107Cerebral edema (HP:0002181)1.74263034
108Partial duplication of the phalanx of hand (HP:0009999)1.74191709
109Neoplasm of the adrenal cortex (HP:0100641)1.74110328
110Increased CSF lactate (HP:0002490)1.73063906
111Dandy-Walker malformation (HP:0001305)1.72898228
112Renal hypoplasia (HP:0000089)1.72723434
113Abnormality of the nasolacrimal system (HP:0000614)1.72443641
114Abnormality of the incisor (HP:0000676)1.71859397
115Absent septum pellucidum (HP:0001331)1.71322661
116Cutaneous finger syndactyly (HP:0010554)1.70848004
117Reticulocytopenia (HP:0001896)1.70069479
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.70012342
119Abnormality of the 4th metacarpal (HP:0010012)1.69379829
120Chromsome breakage (HP:0040012)1.69117671
121Oligodactyly (hands) (HP:0001180)1.68832677
122Bell-shaped thorax (HP:0001591)1.68279993
123Coronal craniosynostosis (HP:0004440)1.67871270
124Abnormality of chromosome stability (HP:0003220)1.67831325
125Poor coordination (HP:0002370)1.67718279
126Aplasia/Hypoplasia of the lens (HP:0008063)1.67027364
127Patellar aplasia (HP:0006443)1.66216405
128Duplication of thumb phalanx (HP:0009942)1.64948715
129Abnormal number of incisors (HP:0011064)1.64930883
130Midline defect of the nose (HP:0004122)1.64316174
131Methylmalonic acidemia (HP:0002912)1.64016091
132Mitochondrial inheritance (HP:0001427)1.63775379
133Wrist flexion contracture (HP:0001239)1.62738511
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62252262
135Optic nerve hypoplasia (HP:0000609)1.62024712
136Maternal diabetes (HP:0009800)1.61696792
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61551027
138Protrusio acetabuli (HP:0003179)1.61169617
139Aplasia involving bones of the upper limbs (HP:0009823)1.60919472
140Aplasia/Hypoplasia of the patella (HP:0006498)1.59735523
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.59384592
142Neoplasm of the adrenal gland (HP:0100631)1.59192687
143Broad toe (HP:0001837)1.59124004
144Soft skin (HP:0000977)1.59013413
145Rimmed vacuoles (HP:0003805)1.58780784
146Abnormality of the lacrimal duct (HP:0011481)1.58257069
147Facial cleft (HP:0002006)1.58078367
148Glossoptosis (HP:0000162)1.57750959
149Cutaneous syndactyly (HP:0012725)1.55681624
150Omphalocele (HP:0001539)1.55549867
151Heterochromia iridis (HP:0001100)1.54418161
152Meningocele (HP:0002435)1.54277047
153Abnormal pancreas size (HP:0012094)1.53345834
154Partial duplication of thumb phalanx (HP:0009944)1.52251389
155Supernumerary bones of the axial skeleton (HP:0009144)1.51969830
156Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.51916770
157Preaxial foot polydactyly (HP:0001841)1.51312358
158Sclerocornea (HP:0000647)1.49890418
159Aplasia of the phalanges of the hand (HP:0009802)1.49649193
160Aplasia involving bones of the extremities (HP:0009825)1.49649193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.24900390
2CASK3.24164409
3BUB12.84676457
4EPHA42.80544113
5ERBB32.79787359
6MAPK132.54128372
7BCR2.49746439
8DYRK22.46855952
9EPHB22.42772385
10MKNK12.40925131
11TRIM282.18414319
12PLK22.09308815
13SRPK12.07375887
14VRK22.07172785
15TTK2.01561990
16NEK12.01163475
17PBK1.99940971
18LIMK11.99630718
19MAPK151.88105207
20MAP4K21.84209953
21UHMK11.83426034
22BMPR1B1.72394571
23CCNB11.71101754
24MST41.65138314
25ACVR1B1.57599988
26MKNK21.55880029
27PLK31.54178739
28TGFBR11.51536500
29CSNK1G31.49265840
30SIK31.48489957
31VRK11.45556627
32ICK1.45438385
33PNCK1.45391346
34TNIK1.45003968
35OBSCN1.38635291
36NTRK21.38137491
37MINK11.37646700
38TIE11.36502194
39PLK41.33319401
40LATS21.30939976
41CDC71.30835122
42STK161.27308389
43CDK81.25558586
44YES11.22876155
45CSNK1A1L1.20847896
46MYLK1.19410518
47WEE11.16914410
48TESK11.16453043
49KSR11.13620526
50GRK11.09718121
51CSNK1G11.09492104
52MAP2K71.08139269
53DYRK31.06146988
54EIF2AK10.99955081
55KDR0.98998745
56CSNK1G20.97661379
57CDK140.96864905
58BCKDK0.96141427
59INSRR0.93206992
60CDK180.92738866
61OXSR10.91882514
62WNK30.91703671
63AURKA0.90291969
64TLK10.88143615
65ZAK0.86279115
66PASK0.86157253
67TSSK60.86011150
68DYRK1A0.85888699
69TAF10.85590279
70STK38L0.83914859
71PDK20.83665872
72NUAK10.80499540
73CDK150.80069473
74ADRBK10.79851573
75ROCK10.79804454
76STK240.78689411
77MAP3K40.78584331
78FGFR10.78492889
79PTK2B0.75977056
80PLK10.74163186
81NME10.73354466
82ADRBK20.72832317
83CDK11A0.72200220
84ATR0.69866848
85LATS10.69316732
86BRSK10.68641402
87ROCK20.67862838
88EIF2AK20.67685467
89CDK70.67427608
90NEK20.67199345
91BRSK20.64080180
92DDR20.61424036
93ILK0.60393188
94TAOK20.59767173
95FER0.59604794
96PAK30.57367243
97STK30.57289617
98WNK40.57153848
99FGFR20.57072806
100PINK10.56883009
101GRK70.56776918
102NTRK30.56397872
103TYRO30.54885704
104ATM0.54501756
105FRK0.54486977
106EPHA20.53709847
107NLK0.52872895
108MAP3K120.52389096
109EIF2AK30.51321099
110CHEK20.51299360
111PRKCG0.51211149
112CLK10.51073135
113DYRK1B0.50887500
114PHKG20.50761706
115PHKG10.50761706
116CDK30.50056588
117BRD40.49819061
118IRAK20.48763452
119PAK20.48578380
120PRKCE0.48151719
121STK390.46828673
122CSNK2A10.46291640
123CDK190.45468577
124PKN10.45332382
125MET0.44255124
126AURKB0.43922069
127NME20.43880012
128CDK10.43554830
129PAK40.43426228
130STK100.42170986
131CAMK2A0.40445014
132PRKD30.39213962
133RPS6KA40.37623524
134ERBB20.37453499
135CHEK10.36985411
136CSNK1A10.35119539
137CSNK2A20.34331304
138CSNK1E0.33647327
139NEK90.29639010
140ERBB40.28684593

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.23785884
2Ribosome_Homo sapiens_hsa030102.99624263
3Parkinsons disease_Homo sapiens_hsa050122.76303475
4Oxidative phosphorylation_Homo sapiens_hsa001902.75697967
5Spliceosome_Homo sapiens_hsa030402.60779791
6RNA polymerase_Homo sapiens_hsa030202.40654277
7Basal cell carcinoma_Homo sapiens_hsa052172.36857240
8Propanoate metabolism_Homo sapiens_hsa006402.36618180
9Huntingtons disease_Homo sapiens_hsa050162.30783394
10Protein export_Homo sapiens_hsa030602.09616662
11Hedgehog signaling pathway_Homo sapiens_hsa043401.97913228
12Alzheimers disease_Homo sapiens_hsa050101.93694718
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93160664
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92819777
15Axon guidance_Homo sapiens_hsa043601.91434181
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87307093
17DNA replication_Homo sapiens_hsa030301.86391268
18Hippo signaling pathway_Homo sapiens_hsa043901.79277589
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78292127
20Cell cycle_Homo sapiens_hsa041101.73733797
21Mismatch repair_Homo sapiens_hsa034301.73674674
22RNA transport_Homo sapiens_hsa030131.68958358
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68905703
24Cardiac muscle contraction_Homo sapiens_hsa042601.63854114
25Pyrimidine metabolism_Homo sapiens_hsa002401.62760476
26Pyruvate metabolism_Homo sapiens_hsa006201.62165363
27Nucleotide excision repair_Homo sapiens_hsa034201.62003114
28Nicotine addiction_Homo sapiens_hsa050331.58065099
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.57170308
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54326472
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52507652
32Fatty acid elongation_Homo sapiens_hsa000621.51861833
33Butanoate metabolism_Homo sapiens_hsa006501.47746375
34Wnt signaling pathway_Homo sapiens_hsa043101.42996958
35Base excision repair_Homo sapiens_hsa034101.42138741
36mRNA surveillance pathway_Homo sapiens_hsa030151.41423078
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39481183
38TGF-beta signaling pathway_Homo sapiens_hsa043501.39189672
39Basal transcription factors_Homo sapiens_hsa030221.38924329
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37943594
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.36910528
42Fatty acid degradation_Homo sapiens_hsa000711.35087519
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34161274
44Caffeine metabolism_Homo sapiens_hsa002321.32476450
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28989235
46Chemical carcinogenesis_Homo sapiens_hsa052041.26285094
47Glutathione metabolism_Homo sapiens_hsa004801.24412436
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23068666
49Retinol metabolism_Homo sapiens_hsa008301.22626954
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22585122
51Oocyte meiosis_Homo sapiens_hsa041141.22419318
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21752234
53RNA degradation_Homo sapiens_hsa030181.20193842
54Homologous recombination_Homo sapiens_hsa034401.17535636
55beta-Alanine metabolism_Homo sapiens_hsa004101.15802544
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15636729
57Folate biosynthesis_Homo sapiens_hsa007901.15041438
58Nitrogen metabolism_Homo sapiens_hsa009101.14479168
59One carbon pool by folate_Homo sapiens_hsa006701.12899635
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10945857
61Peroxisome_Homo sapiens_hsa041461.08517542
62Biosynthesis of amino acids_Homo sapiens_hsa012301.07747226
63Alcoholism_Homo sapiens_hsa050341.07111454
64Tryptophan metabolism_Homo sapiens_hsa003801.06669802
65Purine metabolism_Homo sapiens_hsa002301.03678913
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02868162
67Gap junction_Homo sapiens_hsa045401.02723916
68Histidine metabolism_Homo sapiens_hsa003401.02129134
69Vitamin B6 metabolism_Homo sapiens_hsa007501.01812505
70Fatty acid metabolism_Homo sapiens_hsa012121.00354536
71Carbon metabolism_Homo sapiens_hsa012000.99575824
72Arginine and proline metabolism_Homo sapiens_hsa003300.99525248
73Fanconi anemia pathway_Homo sapiens_hsa034600.97706986
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96681295
75Melanogenesis_Homo sapiens_hsa049160.96126270
76Fat digestion and absorption_Homo sapiens_hsa049750.94276367
77Cocaine addiction_Homo sapiens_hsa050300.93431395
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.93417210
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92654628
80Tyrosine metabolism_Homo sapiens_hsa003500.90656510
81MicroRNAs in cancer_Homo sapiens_hsa052060.90228966
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89812541
83ECM-receptor interaction_Homo sapiens_hsa045120.89733170
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89418087
85Colorectal cancer_Homo sapiens_hsa052100.88968580
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88365334
87Serotonergic synapse_Homo sapiens_hsa047260.87314994
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86776450
89Tight junction_Homo sapiens_hsa045300.85728933
90Dopaminergic synapse_Homo sapiens_hsa047280.83749911
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83547426
92Phenylalanine metabolism_Homo sapiens_hsa003600.82448796
93Vitamin digestion and absorption_Homo sapiens_hsa049770.81659215
94Linoleic acid metabolism_Homo sapiens_hsa005910.81450458
95Metabolic pathways_Homo sapiens_hsa011000.81246355
96Dilated cardiomyopathy_Homo sapiens_hsa054140.80842393
97Endometrial cancer_Homo sapiens_hsa052130.79964495
98Selenocompound metabolism_Homo sapiens_hsa004500.79196635
99Pathways in cancer_Homo sapiens_hsa052000.78989101
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77300987
101Adherens junction_Homo sapiens_hsa045200.77151277
102Amphetamine addiction_Homo sapiens_hsa050310.75246800
103Focal adhesion_Homo sapiens_hsa045100.73979029
104Glutamatergic synapse_Homo sapiens_hsa047240.73299197
105Viral myocarditis_Homo sapiens_hsa054160.72997378
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72834991
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72251060
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71848270
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71749755
110Circadian entrainment_Homo sapiens_hsa047130.71209044
111Epstein-Barr virus infection_Homo sapiens_hsa051690.70887643
112Vibrio cholerae infection_Homo sapiens_hsa051100.70585193
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69923127
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69735450
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69305504
116Phototransduction_Homo sapiens_hsa047440.69193279
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66381884
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63324185
119Sulfur relay system_Homo sapiens_hsa041220.62837479
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.61772766
121Melanoma_Homo sapiens_hsa052180.61746732
122Long-term depression_Homo sapiens_hsa047300.61464187
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60178337
124Taste transduction_Homo sapiens_hsa047420.59936225
125Renal cell carcinoma_Homo sapiens_hsa052110.59693832
126N-Glycan biosynthesis_Homo sapiens_hsa005100.59155420
127GABAergic synapse_Homo sapiens_hsa047270.57983818
128Cholinergic synapse_Homo sapiens_hsa047250.57309599
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56358307
130Ras signaling pathway_Homo sapiens_hsa040140.55090998
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54670812
132Arginine biosynthesis_Homo sapiens_hsa002200.54390393
133Rap1 signaling pathway_Homo sapiens_hsa040150.53521628
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53394815
135HTLV-I infection_Homo sapiens_hsa051660.53316464
136Sulfur metabolism_Homo sapiens_hsa009200.52604808
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52290947
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.51480053
139Prostate cancer_Homo sapiens_hsa052150.51294334
140Proteoglycans in cancer_Homo sapiens_hsa052050.51287239
141Lysine degradation_Homo sapiens_hsa003100.48590490
142Steroid biosynthesis_Homo sapiens_hsa001000.48480268
143Morphine addiction_Homo sapiens_hsa050320.47772602
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.47308881
145p53 signaling pathway_Homo sapiens_hsa041150.46403942
146Arachidonic acid metabolism_Homo sapiens_hsa005900.46078468
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45381224
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43841977
149ErbB signaling pathway_Homo sapiens_hsa040120.43559279
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42665154
151Glioma_Homo sapiens_hsa052140.41088220
152Systemic lupus erythematosus_Homo sapiens_hsa053220.40661657
153Notch signaling pathway_Homo sapiens_hsa043300.40436067
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39808401
155Olfactory transduction_Homo sapiens_hsa047400.39320322
156Non-homologous end-joining_Homo sapiens_hsa034500.36715795
157Calcium signaling pathway_Homo sapiens_hsa040200.35334810
158Oxytocin signaling pathway_Homo sapiens_hsa049210.34054338

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