TSPAN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61177048
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.30424990
3synaptic vesicle exocytosis (GO:0016079)5.27533148
4neurotransmitter-gated ion channel clustering (GO:0072578)5.23954445
5vocalization behavior (GO:0071625)5.13418949
6glutamate secretion (GO:0014047)5.11562078
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10457278
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02063069
9locomotory exploration behavior (GO:0035641)4.98430577
10synaptic vesicle maturation (GO:0016188)4.91049326
11regulation of synaptic vesicle exocytosis (GO:2000300)4.85440689
12regulation of glutamate receptor signaling pathway (GO:1900449)4.73052509
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.67092604
14neuron cell-cell adhesion (GO:0007158)4.52291918
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44672205
16neuronal action potential propagation (GO:0019227)4.41363535
17protein localization to synapse (GO:0035418)4.36091258
18regulation of synaptic vesicle transport (GO:1902803)4.33017443
19neurotransmitter secretion (GO:0007269)4.32582512
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.30052510
21synaptic transmission, glutamatergic (GO:0035249)4.09791160
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.08920381
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08150734
24neuron-neuron synaptic transmission (GO:0007270)4.00766023
25glutamate receptor signaling pathway (GO:0007215)3.98628521
26presynaptic membrane assembly (GO:0097105)3.93377043
27long-term synaptic potentiation (GO:0060291)3.93237731
28regulation of neuronal synaptic plasticity (GO:0048168)3.92697358
29gamma-aminobutyric acid transport (GO:0015812)3.84799894
30potassium ion homeostasis (GO:0055075)3.83869832
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83327301
32exploration behavior (GO:0035640)3.81875387
33postsynaptic membrane organization (GO:0001941)3.79607698
34regulation of synapse structural plasticity (GO:0051823)3.77715480
35positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.75374573
36regulation of synaptic transmission, glutamatergic (GO:0051966)3.72125405
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63159160
38potassium ion import (GO:0010107)3.62213383
39auditory behavior (GO:0031223)3.61607333
40presynaptic membrane organization (GO:0097090)3.60327019
41long-term memory (GO:0007616)3.59011676
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.57660830
43cellular potassium ion homeostasis (GO:0030007)3.57195821
44neuronal ion channel clustering (GO:0045161)3.56357598
45response to auditory stimulus (GO:0010996)3.55882246
46response to histamine (GO:0034776)3.49712751
47regulation of synaptic plasticity (GO:0048167)3.48697689
48positive regulation of synapse maturation (GO:0090129)3.48112049
49central nervous system myelination (GO:0022010)3.48025561
50axon ensheathment in central nervous system (GO:0032291)3.48025561
51neurotransmitter transport (GO:0006836)3.47138369
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45713181
53positive regulation of membrane potential (GO:0045838)3.44321767
54proline transport (GO:0015824)3.44056991
55regulation of postsynaptic membrane potential (GO:0060078)3.43082375
56neurotransmitter uptake (GO:0001504)3.41420852
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40663829
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40528163
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.39433802
60mechanosensory behavior (GO:0007638)3.38276054
61cellular sodium ion homeostasis (GO:0006883)3.37585249
62positive regulation of dendritic spine development (GO:0060999)3.37429106
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.37404737
64regulation of neurotransmitter secretion (GO:0046928)3.36014622
65cerebellar granule cell differentiation (GO:0021707)3.31972039
66membrane depolarization during action potential (GO:0086010)3.30496105
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26330138
68positive regulation of neurotransmitter transport (GO:0051590)3.25362073
69regulation of neurotransmitter levels (GO:0001505)3.24172664
70positive regulation of synaptic transmission (GO:0050806)3.22651446
71activation of protein kinase A activity (GO:0034199)3.20655155
72dendritic spine organization (GO:0097061)3.18968145
73regulation of neurotransmitter transport (GO:0051588)3.18503562
74transmission of nerve impulse (GO:0019226)3.16999486
75layer formation in cerebral cortex (GO:0021819)3.16594334
76positive regulation of neurotransmitter secretion (GO:0001956)3.15651753
77L-amino acid import (GO:0043092)3.14483324
78regulation of dendritic spine development (GO:0060998)3.14359457
79acidic amino acid transport (GO:0015800)3.12949183
80regulation of vesicle fusion (GO:0031338)3.08453335
81startle response (GO:0001964)3.07203098
82neuromuscular synaptic transmission (GO:0007274)3.06706644
83regulation of synaptic transmission (GO:0050804)3.01810686
84synaptic vesicle endocytosis (GO:0048488)3.00731538
85cerebellar Purkinje cell differentiation (GO:0021702)3.00513703
86regulation of beta-amyloid formation (GO:1902003)3.00428581
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00325666
88neuron recognition (GO:0008038)2.99627935
89synaptic vesicle transport (GO:0048489)2.98442151
90establishment of synaptic vesicle localization (GO:0097480)2.98442151
91axonal fasciculation (GO:0007413)2.98149080
92positive regulation of dendritic spine morphogenesis (GO:0061003)2.98020637
93establishment of mitochondrion localization (GO:0051654)2.97605152
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96653387
95neuromuscular process controlling posture (GO:0050884)2.96169239
96regulation of female receptivity (GO:0045924)2.95583242
97synaptic transmission (GO:0007268)2.94739514
98cell communication by electrical coupling (GO:0010644)2.94317288
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93139408
100regulation of voltage-gated calcium channel activity (GO:1901385)2.91758204
101membrane depolarization (GO:0051899)2.91718326
102neuromuscular process controlling balance (GO:0050885)2.91671266
103behavioral fear response (GO:0001662)2.91089555
104behavioral defense response (GO:0002209)2.91089555
105membrane hyperpolarization (GO:0060081)2.90381194
106female mating behavior (GO:0060180)2.90060099
107cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89743687
108regulation of synaptic transmission, GABAergic (GO:0032228)2.89724122
109regulation of dendritic spine morphogenesis (GO:0061001)2.88438810
110sodium ion export (GO:0071436)2.87888859
111regulation of synapse maturation (GO:0090128)2.87177708
112C4-dicarboxylate transport (GO:0015740)2.86096494
113learning (GO:0007612)2.86070802
114dendritic spine morphogenesis (GO:0060997)2.85793838
115amino acid import (GO:0043090)2.85779499
116synapse assembly (GO:0007416)2.85730358
117striatum development (GO:0021756)2.85702137
118detection of calcium ion (GO:0005513)2.84288625
119transferrin transport (GO:0033572)2.81660617
120negative regulation of dendrite morphogenesis (GO:0050774)2.81643336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26992347
2GBX2_23144817_ChIP-Seq_PC3_Human3.92240216
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21941139
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16751216
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87790326
6REST_21632747_ChIP-Seq_MESCs_Mouse2.66848498
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65346289
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64672285
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59900787
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59321151
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58134177
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58134177
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50060742
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47915995
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.46263966
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.42180465
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.41502562
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.24375800
19DROSHA_22980978_ChIP-Seq_HELA_Human2.23726573
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14090376
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.13311381
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.11931008
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11877642
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10622243
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04218511
26AR_21572438_ChIP-Seq_LNCaP_Human1.89403753
27TAF15_26573619_Chip-Seq_HEK293_Human1.88066760
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86166103
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85670875
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82394425
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77905223
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77324655
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75297427
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.71370814
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71074138
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69424625
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67483419
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62746353
39P300_19829295_ChIP-Seq_ESCs_Human1.58624508
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45762480
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.42933779
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.42448312
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.40232637
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39404160
45AR_25329375_ChIP-Seq_VCAP_Human1.37905729
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37503178
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.36850006
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.33599083
49IGF1R_20145208_ChIP-Seq_DFB_Human1.33402278
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32270216
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31994067
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.31393154
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29340835
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28085299
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26901592
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26183833
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25009007
58STAT3_23295773_ChIP-Seq_U87_Human1.24989405
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23813348
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19659788
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.18570412
62* AR_19668381_ChIP-Seq_PC3_Human1.17721813
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15416978
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15308285
65ZNF274_21170338_ChIP-Seq_K562_Hela1.15030138
66TCF4_23295773_ChIP-Seq_U87_Human1.11644318
67* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07945595
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07809988
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07220058
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.06259601
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06207265
72FUS_26573619_Chip-Seq_HEK293_Human1.05854899
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.05835972
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05781083
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04046779
76RUNX2_22187159_ChIP-Seq_PCA_Human1.03376471
77VDR_22108803_ChIP-Seq_LS180_Human1.03276513
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03070675
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02834075
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02383434
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01453431
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00725081
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00402275
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99859915
85ER_23166858_ChIP-Seq_MCF-7_Human0.97146510
86TET1_21490601_ChIP-Seq_MESCs_Mouse0.96801811
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95615889
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.95401100
89RXR_22108803_ChIP-Seq_LS180_Human0.95170910
90AHR_22903824_ChIP-Seq_MCF-7_Human0.95160004
91SMAD3_21741376_ChIP-Seq_ESCs_Human0.94630975
92BCAT_22108803_ChIP-Seq_LS180_Human0.93688284
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.93166698
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92295658
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90796235
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89998415
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89621891
98TP53_18474530_ChIP-ChIP_U2OS_Human0.89403730
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89233678
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88537785
101JUN_21703547_ChIP-Seq_K562_Human0.88319376
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.88307053
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88240320
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88240320
105RING1B_27294783_Chip-Seq_NPCs_Mouse0.87504166
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85956302
107KDM2B_26808549_Chip-Seq_REH_Human0.85047660
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84010152
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83480047
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.83237551
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.81211988
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.79962171
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.79267557
114P53_22387025_ChIP-Seq_ESCs_Mouse0.79246416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.66027270
2MP0003880_abnormal_central_pattern4.51378598
3MP0003635_abnormal_synaptic_transmissio3.94062479
4MP0009745_abnormal_behavioral_response3.42818585
5MP0004270_analgesia3.27363085
6MP0002064_seizures3.21469962
7MP0002063_abnormal_learning/memory/cond3.20020361
8MP0009046_muscle_twitch3.15857601
9MP0002822_catalepsy2.98726543
10MP0001968_abnormal_touch/_nociception2.89096498
11MP0002572_abnormal_emotion/affect_behav2.88945450
12MP0009780_abnormal_chondrocyte_physiolo2.73836634
13MP0001486_abnormal_startle_reflex2.59181876
14MP0002272_abnormal_nervous_system2.58538880
15MP0005646_abnormal_pituitary_gland2.56012182
16MP0002734_abnormal_mechanical_nocicepti2.48039896
17MP0002736_abnormal_nociception_after2.47301075
18MP0001501_abnormal_sleep_pattern2.30738428
19MP0005423_abnormal_somatic_nervous2.23923647
20MP0001440_abnormal_grooming_behavior2.03486015
21MP0003329_amyloid_beta_deposits2.02645566
22MP0002067_abnormal_sensory_capabilities1.97348766
23MP0002733_abnormal_thermal_nociception1.96783327
24MP0002909_abnormal_adrenal_gland1.94284269
25MP0002735_abnormal_chemical_nociception1.92664118
26MP0001970_abnormal_pain_threshold1.87774855
27MP0008569_lethality_at_weaning1.87702179
28MP0001984_abnormal_olfaction1.82994307
29MP0004858_abnormal_nervous_system1.77035595
30MP0002557_abnormal_social/conspecific_i1.76155440
31MP0005645_abnormal_hypothalamus_physiol1.73201255
32MP0003879_abnormal_hair_cell1.71930586
33MP0003787_abnormal_imprinting1.66946877
34MP0000013_abnormal_adipose_tissue1.66230673
35MP0001502_abnormal_circadian_rhythm1.61785143
36MP0005386_behavior/neurological_phenoty1.60172162
37MP0004924_abnormal_behavior1.60172162
38MP0004885_abnormal_endolymph1.55906385
39MP0002184_abnormal_innervation1.51957952
40MP0003183_abnormal_peptide_metabolism1.48909840
41MP0001529_abnormal_vocalization1.47813033
42MP0003633_abnormal_nervous_system1.44377304
43MP0003122_maternal_imprinting1.43601808
44MP0004811_abnormal_neuron_physiology1.43062181
45MP0000778_abnormal_nervous_system1.40638295
46MP0002066_abnormal_motor_capabilities/c1.33011479
47MP0002882_abnormal_neuron_morphology1.31130039
48MP0000955_abnormal_spinal_cord1.29949716
49MP0001905_abnormal_dopamine_level1.27607834
50MP0000920_abnormal_myelination1.25044917
51MP0006276_abnormal_autonomic_nervous1.24464822
52MP0004142_abnormal_muscle_tone1.24236882
53MP0008877_abnormal_DNA_methylation1.22152875
54MP0005551_abnormal_eye_electrophysiolog1.19876296
55MP0003631_nervous_system_phenotype1.19800239
56MP0002837_dystrophic_cardiac_calcinosis1.15317305
57MP0003690_abnormal_glial_cell1.14683997
58MP0004043_abnormal_pH_regulation1.14645043
59MP0001188_hyperpigmentation1.12879395
60MP0000751_myopathy1.04475747
61MP0002876_abnormal_thyroid_physiology1.03860665
62MP0010386_abnormal_urinary_bladder1.03276541
63MP0002638_abnormal_pupillary_reflex1.01715474
64MP0003121_genomic_imprinting1.01278076
65MP0003123_paternal_imprinting0.98185926
66MP0004215_abnormal_myocardial_fiber0.97951531
67MP0002069_abnormal_eating/drinking_beha0.95487551
68MP0002229_neurodegeneration0.95144104
69MP0002152_abnormal_brain_morphology0.94862357
70MP0003075_altered_response_to0.93559530
71MP0003634_abnormal_glial_cell0.91417868
72MP0004147_increased_porphyrin_level0.91331438
73MP0004085_abnormal_heartbeat0.91283944
74MP0001963_abnormal_hearing_physiology0.90394679
75MP0000604_amyloidosis0.89571175
76MP0008872_abnormal_physiological_respon0.87382347
77MP0001485_abnormal_pinna_reflex0.86505718
78MP0002090_abnormal_vision0.85666323
79MP0005535_abnormal_body_temperature0.84931461
80MP0001664_abnormal_digestion0.84453814
81MP0003632_abnormal_nervous_system0.83022789
82MP0008874_decreased_physiological_sensi0.82697875
83MP0001177_atelectasis0.81562399
84MP0000631_abnormal_neuroendocrine_gland0.79379696
85MP0005379_endocrine/exocrine_gland_phen0.77743755
86MP0002102_abnormal_ear_morphology0.77164094
87MP0005171_absent_coat_pigmentation0.76689307
88MP0001986_abnormal_taste_sensitivity0.75486430
89MP0004145_abnormal_muscle_electrophysio0.71280822
90MP0004742_abnormal_vestibular_system0.70309518
91MP0004233_abnormal_muscle_weight0.69051011
92MP0003283_abnormal_digestive_organ0.68367948
93MP0002752_abnormal_somatic_nervous0.67833861
94MP0002653_abnormal_ependyma_morphology0.66707727
95MP0003137_abnormal_impulse_conducting0.63531142
96MP0000639_abnormal_adrenal_gland0.62489377
97MP0005394_taste/olfaction_phenotype0.61012904
98MP0005499_abnormal_olfactory_system0.61012904
99MP0005253_abnormal_eye_physiology0.60668437
100MP0005167_abnormal_blood-brain_barrier0.60655869
101MP0006072_abnormal_retinal_apoptosis0.60516027
102MP0004130_abnormal_muscle_cell0.58778689
103MP0008961_abnormal_basal_metabolism0.58496860
104MP0000026_abnormal_inner_ear0.56776601
105MP0004484_altered_response_of0.55454525
106MP0010769_abnormal_survival0.53326618
107MP0001943_abnormal_respiration0.53049851
108MP0005595_abnormal_vascular_smooth0.52961979
109MP0002082_postnatal_lethality0.52289434
110MP0010770_preweaning_lethality0.52289434
111MP0003956_abnormal_body_size0.51225480

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.92431990
2Myokymia (HP:0002411)5.89277625
3Epileptic encephalopathy (HP:0200134)5.67613700
4Focal seizures (HP:0007359)5.25769163
5Atonic seizures (HP:0010819)5.11538692
6Febrile seizures (HP:0002373)4.62880461
7Visual hallucinations (HP:0002367)4.47927412
8Hyperventilation (HP:0002883)4.45544170
9Absence seizures (HP:0002121)4.04018204
10Progressive cerebellar ataxia (HP:0002073)3.98617864
11Generalized tonic-clonic seizures (HP:0002069)3.83803442
12Dialeptic seizures (HP:0011146)3.80787876
13Broad-based gait (HP:0002136)3.31353282
14Action tremor (HP:0002345)3.19087609
15Dysdiadochokinesis (HP:0002075)3.18991567
16Depression (HP:0000716)3.18140484
17Abnormal eating behavior (HP:0100738)3.17500982
18Anxiety (HP:0000739)3.11257712
19Cerebral hypomyelination (HP:0006808)3.11081947
20Gaze-evoked nystagmus (HP:0000640)3.10865310
21Impaired vibration sensation in the lower limbs (HP:0002166)3.01123826
22Truncal ataxia (HP:0002078)3.00621863
23Poor eye contact (HP:0000817)2.99504208
24Pheochromocytoma (HP:0002666)2.97205395
25Megalencephaly (HP:0001355)2.92213573
26Epileptiform EEG discharges (HP:0011182)2.89517565
27Abnormality of the corticospinal tract (HP:0002492)2.89319957
28Diplopia (HP:0000651)2.88813381
29Abnormality of binocular vision (HP:0011514)2.88813381
30Hemiparesis (HP:0001269)2.77930257
31Akinesia (HP:0002304)2.75218805
32Postural instability (HP:0002172)2.74661642
33Delusions (HP:0000746)2.73288603
34Dysmetria (HP:0001310)2.72953028
35Ankle clonus (HP:0011448)2.72471045
36Supranuclear gaze palsy (HP:0000605)2.71461615
37Neuroendocrine neoplasm (HP:0100634)2.69765083
38Abnormal social behavior (HP:0012433)2.69738182
39Impaired social interactions (HP:0000735)2.69738182
40EEG with generalized epileptiform discharges (HP:0011198)2.68187521
41Polyphagia (HP:0002591)2.61097227
42Neurofibrillary tangles (HP:0002185)2.56494480
43Hypsarrhythmia (HP:0002521)2.55511178
44Drooling (HP:0002307)2.51614048
45Excessive salivation (HP:0003781)2.51614048
46Amblyopia (HP:0000646)2.49715446
47Tetraplegia (HP:0002445)2.49326098
48Sleep apnea (HP:0010535)2.49201037
49Papilledema (HP:0001085)2.48603572
50Gait imbalance (HP:0002141)2.45628326
51Aplasia involving bones of the upper limbs (HP:0009823)2.43399217
52Aplasia of the phalanges of the hand (HP:0009802)2.43399217
53Aplasia involving bones of the extremities (HP:0009825)2.43399217
54Hemiplegia (HP:0002301)2.43329387
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.42165729
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42165729
57Status epilepticus (HP:0002133)2.42052802
58Impaired smooth pursuit (HP:0007772)2.41094379
59Dysmetric saccades (HP:0000641)2.40888197
60Bradykinesia (HP:0002067)2.39738842
61Scanning speech (HP:0002168)2.36259128
62Peripheral hypomyelination (HP:0007182)2.35433712
63Urinary bladder sphincter dysfunction (HP:0002839)2.34853033
64Torticollis (HP:0000473)2.34837331
65Clonus (HP:0002169)2.31786258
66Cerebral inclusion bodies (HP:0100314)2.30551743
67Resting tremor (HP:0002322)2.28926081
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26426128
69Increased circulating renin level (HP:0000848)2.24870623
70Focal dystonia (HP:0004373)2.24077686
71Congenital primary aphakia (HP:0007707)2.23712790
72Impaired vibratory sensation (HP:0002495)2.23655321
73Medial flaring of the eyebrow (HP:0010747)2.20455358
74Stereotypic behavior (HP:0000733)2.19457093
75Blue irides (HP:0000635)2.19266610
76Amyotrophic lateral sclerosis (HP:0007354)2.17023940
77Abnormal hair whorl (HP:0010721)2.15909950
78Neuronal loss in central nervous system (HP:0002529)2.15546549
79Spastic tetraplegia (HP:0002510)2.14251931
80Genetic anticipation (HP:0003743)2.13668236
81Fetal akinesia sequence (HP:0001989)2.12385375
82Morphological abnormality of the pyramidal tract (HP:0002062)2.09967273
83Failure to thrive in infancy (HP:0001531)2.09555897
84Nephrogenic diabetes insipidus (HP:0009806)2.09529876
85Limb dystonia (HP:0002451)2.08109127
86Abnormality of ocular smooth pursuit (HP:0000617)2.07671833
87Poor suck (HP:0002033)2.07510100
88CNS hypomyelination (HP:0003429)2.05825345
89Spastic gait (HP:0002064)2.05526369
90Progressive inability to walk (HP:0002505)2.05434571
91Absent speech (HP:0001344)2.03778724
92Protruding tongue (HP:0010808)2.02272112
93Gait ataxia (HP:0002066)2.01848929
94Muscular hypotonia of the trunk (HP:0008936)1.99256627
95Generalized myoclonic seizures (HP:0002123)1.97574993
96Postural tremor (HP:0002174)1.95832722
97Choreoathetosis (HP:0001266)1.95232370
98Abnormality of the lower motor neuron (HP:0002366)1.95072811
99Urinary urgency (HP:0000012)1.94419061
100Craniofacial dystonia (HP:0012179)1.94304163
101Narrow nasal bridge (HP:0000446)1.93941063
102Thickened helices (HP:0000391)1.93700214
103Specific learning disability (HP:0001328)1.93564440
104Spastic tetraparesis (HP:0001285)1.93402459
105Spinal canal stenosis (HP:0003416)1.93398900
106Lower limb muscle weakness (HP:0007340)1.91417925
107Apathy (HP:0000741)1.90748367
108Clumsiness (HP:0002312)1.90629575
109Inability to walk (HP:0002540)1.89376297
110Annular pancreas (HP:0001734)1.89146687
111Split foot (HP:0001839)1.87899343
112Rigidity (HP:0002063)1.87555208
113Intention tremor (HP:0002080)1.86883898
114Agitation (HP:0000713)1.86512629
115Incomplete penetrance (HP:0003829)1.83928356
116Psychosis (HP:0000709)1.81496344
117Prolonged QT interval (HP:0001657)1.79663475
118Limb ataxia (HP:0002070)1.79399939
119Menstrual irregularities (HP:0000858)1.78901297
120Hyperthyroidism (HP:0000836)1.77747585
121Obstructive sleep apnea (HP:0002870)1.77132476
122Mutism (HP:0002300)1.76645214
123Bundle branch block (HP:0011710)1.76490518
124Abnormality of saccadic eye movements (HP:0000570)1.74268382
125Neoplasm of the peripheral nervous system (HP:0100007)1.74196000
126Diminished motivation (HP:0000745)1.74053799
127Diminished movement (HP:0002374)1.71747892
128Ventricular fibrillation (HP:0001663)1.70912558
129Abnormal EKG (HP:0003115)1.70859114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.97454517
2CASK4.44930626
3NTRK34.11311631
4MAP3K92.77509643
5DAPK22.77135042
6MAP3K42.69943262
7MAP2K72.66941991
8MAP3K122.29370025
9PRPF4B2.14913124
10NTRK22.08228555
11MINK12.02572884
12CDK191.99150326
13PRKD31.91813636
14DAPK11.86147187
15PLK21.77784720
16MARK11.75117008
17MAP2K41.64021327
18TNIK1.60962378
19PAK61.55111205
20KSR21.54748911
21CAMKK11.43167669
22AKT31.43054353
23FRK1.42610093
24CDK51.40028461
25CCNB11.39105990
26LMTK21.38167156
27SGK4941.34811133
28SGK2231.34811133
29RIPK41.34151642
30PRKCG1.33139359
31SGK21.33125255
32PHKG21.32856187
33PHKG11.32856187
34NTRK11.31821860
35ARAF1.31126228
36GRK51.29769213
37KSR11.23532612
38MAPK131.22622477
39CAMKK21.20727673
40OXSR11.15791478
41CAMK2A1.04080820
42MAP3K131.03665678
43MUSK1.03384338
44SGK30.97472006
45FGFR20.97232143
46MAP3K20.96861572
47SIK30.94395575
48PINK10.94359140
49WNK30.94173689
50UHMK10.93229978
51PRKCH0.90130092
52STK380.89758693
53FES0.88231832
54CAMK2B0.86969554
55CSNK1G30.86884412
56LIMK10.85462521
57PTK2B0.83426685
58CAMK10.82378146
59PKN10.82311804
60CDK180.80767072
61DYRK20.80755737
62PRKCE0.80704198
63SIK20.78610645
64CSNK1A1L0.77855060
65BMPR20.76576862
66CDK150.76132309
67MAP4K20.74472487
68CDK140.73238307
69PDK30.73074877
70PDK40.73074877
71BRAF0.72668091
72SGK10.72461789
73CSNK1G10.71263527
74INSRR0.69316276
75DYRK1A0.67863160
76TSSK60.66294836
77NME10.64873910
78CDK11A0.63833418
79TYRO30.63360379
80BCR0.61480261
81PRKCZ0.61176592
82MAP3K10.60937503
83ERBB30.60187577
84LATS20.57363170
85PAK30.56827965
86PDPK10.56346257
87MAPK100.55687525
88PDK10.52978861
89CAMK2D0.52606072
90CAMK2G0.51721140
91STK110.50824344
92TESK10.48663560
93MAPK70.48359184
94DAPK30.47803308
95ALK0.47774375
96RET0.47267502
97RAF10.47041809
98RIPK10.46579746
99ADRBK10.45128678
100RPS6KA30.44703945
101NEK60.44666879
102TNK20.44519821
103MAPK120.44489376
104FER0.44306734
105MARK20.43628993
106MAP2K60.43580811
107CDC42BPA0.43201116
108CAMK40.43133315
109MAP2K10.43048472
110PRKG10.43036373
111TRIM280.42220678
112MAP3K110.41873363
113ROCK20.41113835
114PDK20.37688968
115CDK30.37561568
116PNCK0.37544761
117CSNK1D0.37045338
118CSNK1A10.36766174
119PRKACA0.36600361
120PRKAA10.36119207
121NEK10.35645799
122CSNK1G20.35577483
123FGR0.35033326
124PRKCA0.34614464
125OBSCN0.33660217
126TAOK10.32122289
127CSNK1E0.30728381
128ROCK10.29883465

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82938860
2Synaptic vesicle cycle_Homo sapiens_hsa047213.65667768
3GABAergic synapse_Homo sapiens_hsa047272.82066057
4Olfactory transduction_Homo sapiens_hsa047402.74865114
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69840563
6Circadian entrainment_Homo sapiens_hsa047132.65162873
7Morphine addiction_Homo sapiens_hsa050322.59733484
8Glutamatergic synapse_Homo sapiens_hsa047242.49723881
9Collecting duct acid secretion_Homo sapiens_hsa049662.40356496
10Amphetamine addiction_Homo sapiens_hsa050312.40264821
11Long-term potentiation_Homo sapiens_hsa047202.38147515
12Insulin secretion_Homo sapiens_hsa049112.28464114
13Salivary secretion_Homo sapiens_hsa049702.06338672
14Dopaminergic synapse_Homo sapiens_hsa047282.00399869
15Taste transduction_Homo sapiens_hsa047421.90679157
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86300392
17Cocaine addiction_Homo sapiens_hsa050301.78021778
18Gastric acid secretion_Homo sapiens_hsa049711.76733742
19Cholinergic synapse_Homo sapiens_hsa047251.67730836
20Vibrio cholerae infection_Homo sapiens_hsa051101.65063892
21Serotonergic synapse_Homo sapiens_hsa047261.64014103
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58659837
23Renin secretion_Homo sapiens_hsa049241.58318194
24Long-term depression_Homo sapiens_hsa047301.57544999
25Calcium signaling pathway_Homo sapiens_hsa040201.57380255
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45886687
27Oxytocin signaling pathway_Homo sapiens_hsa049211.40624862
28Nitrogen metabolism_Homo sapiens_hsa009101.39636748
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38405990
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37279008
31Vitamin B6 metabolism_Homo sapiens_hsa007501.35173495
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29623303
33cAMP signaling pathway_Homo sapiens_hsa040241.20949480
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14111672
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14072434
36Gap junction_Homo sapiens_hsa045401.13805941
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13130657
38GnRH signaling pathway_Homo sapiens_hsa049121.09858449
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07079940
40Phototransduction_Homo sapiens_hsa047441.00425405
41Type II diabetes mellitus_Homo sapiens_hsa049300.98618005
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96802220
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95121869
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93830842
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92607160
46Type I diabetes mellitus_Homo sapiens_hsa049400.92384256
47Estrogen signaling pathway_Homo sapiens_hsa049150.89630654
48Circadian rhythm_Homo sapiens_hsa047100.89505511
49Fatty acid biosynthesis_Homo sapiens_hsa000610.88800223
50Cardiac muscle contraction_Homo sapiens_hsa042600.88140256
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.85405937
52Melanogenesis_Homo sapiens_hsa049160.83003672
53Pancreatic secretion_Homo sapiens_hsa049720.82047650
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80485676
55Axon guidance_Homo sapiens_hsa043600.75621934
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74995420
57Glioma_Homo sapiens_hsa052140.74509811
58ErbB signaling pathway_Homo sapiens_hsa040120.74010427
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.73254098
60Thyroid hormone synthesis_Homo sapiens_hsa049180.71327720
61Oxidative phosphorylation_Homo sapiens_hsa001900.68835507
62Dilated cardiomyopathy_Homo sapiens_hsa054140.66745751
63Glucagon signaling pathway_Homo sapiens_hsa049220.65292124
64Arginine and proline metabolism_Homo sapiens_hsa003300.62222981
65Arginine biosynthesis_Homo sapiens_hsa002200.62165959
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61308008
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.60549033
68Rheumatoid arthritis_Homo sapiens_hsa053230.59643299
69Dorso-ventral axis formation_Homo sapiens_hsa043200.58594800
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58316246
71Regulation of autophagy_Homo sapiens_hsa041400.57606031
72beta-Alanine metabolism_Homo sapiens_hsa004100.57100122
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55688353
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55564365
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53582868
76Alzheimers disease_Homo sapiens_hsa050100.53374083
77MAPK signaling pathway_Homo sapiens_hsa040100.53348023
78Histidine metabolism_Homo sapiens_hsa003400.51698634
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51486470
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49563852
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48548027
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47097301
83Oocyte meiosis_Homo sapiens_hsa041140.46905748
84Alcoholism_Homo sapiens_hsa050340.46027347
85Ras signaling pathway_Homo sapiens_hsa040140.45659256
86Butanoate metabolism_Homo sapiens_hsa006500.44733081
87Mineral absorption_Homo sapiens_hsa049780.43222155
88Bile secretion_Homo sapiens_hsa049760.43205681
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41526823
90Rap1 signaling pathway_Homo sapiens_hsa040150.41118553
91Choline metabolism in cancer_Homo sapiens_hsa052310.40328396
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40019126
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39344150
94AMPK signaling pathway_Homo sapiens_hsa041520.38132349
95Inositol phosphate metabolism_Homo sapiens_hsa005620.37583849
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35314703
97Prion diseases_Homo sapiens_hsa050200.35057092
98Ether lipid metabolism_Homo sapiens_hsa005650.34678576
99African trypanosomiasis_Homo sapiens_hsa051430.33138927
100Phagosome_Homo sapiens_hsa041450.31443151
101Parkinsons disease_Homo sapiens_hsa050120.31280506
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.31219364
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.31156333
104Insulin signaling pathway_Homo sapiens_hsa049100.30070472
105Ovarian steroidogenesis_Homo sapiens_hsa049130.29378034
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28879875
107Fatty acid metabolism_Homo sapiens_hsa012120.28850320
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.28148323
109Fructose and mannose metabolism_Homo sapiens_hsa000510.27252100
110Folate biosynthesis_Homo sapiens_hsa007900.26590967
111Endocytosis_Homo sapiens_hsa041440.26262169
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25697935
113Fatty acid elongation_Homo sapiens_hsa000620.25109420
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24760632
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24045741

Most similar genes based on co-expression Upload to Enrichr

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