TSPAN8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)6.88120339
2intestinal epithelial cell development (GO:0060576)6.73195244
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.68411727
4regulation of guanylate cyclase activity (GO:0031282)6.64888838
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.62918135
6calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.79795366
7UDP-N-acetylglucosamine metabolic process (GO:0006047)5.59551077
8intestinal absorption (GO:0050892)5.59436105
9maintenance of gastrointestinal epithelium (GO:0030277)5.50333372
10interferon-gamma secretion (GO:0072643)5.28657224
11NADH metabolic process (GO:0006734)5.28220594
12regulation of cellular extravasation (GO:0002691)5.21206165
13epoxygenase P450 pathway (GO:0019373)5.19207462
14positive regulation of respiratory burst (GO:0060267)5.15893573
15desmosome organization (GO:0002934)5.12505383
16cellular glucuronidation (GO:0052695)5.03032945
17diol metabolic process (GO:0034311)5.00532592
18glucuronate metabolic process (GO:0019585)4.92405942
19uronic acid metabolic process (GO:0006063)4.92405942
20positive regulation of guanylate cyclase activity (GO:0031284)4.88692633
21hepatocyte apoptotic process (GO:0097284)4.83825777
22regulation of water loss via skin (GO:0033561)4.83824194
23regulation of systemic arterial blood pressure by hormone (GO:0001990)4.78295699
24regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.78295699
25endocrine process (GO:0050886)4.78295699
26sphingoid metabolic process (GO:0046519)4.75050057
27sphingosine metabolic process (GO:0006670)4.74967560
28actin filament depolymerization (GO:0030042)4.52099938
29regulation of bile acid biosynthetic process (GO:0070857)4.45073989
30hemidesmosome assembly (GO:0031581)4.44151259
31positive regulation of pseudopodium assembly (GO:0031274)4.43008212
32establishment of skin barrier (GO:0061436)4.42326576
33fat-soluble vitamin biosynthetic process (GO:0042362)4.37939839
34lipoprotein transport (GO:0042953)4.34593061
35membrane budding (GO:0006900)4.33249327
36tight junction assembly (GO:0070830)4.30859031
37O-glycan processing (GO:0016266)4.29300745
38regulation of systemic arterial blood pressure (GO:0003073)4.29084415
39receptor guanylyl cyclase signaling pathway (GO:0007168)4.26283046
40glomerular filtration (GO:0003094)4.19756187
41epithelial structure maintenance (GO:0010669)4.17448497
42phospholipid scrambling (GO:0017121)4.17440784
43regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.16520456
44ethanol oxidation (GO:0006069)4.15863874
45renal system process involved in regulation of blood volume (GO:0001977)4.09981117
46hormone catabolic process (GO:0042447)4.07178899
47regulation of cGMP biosynthetic process (GO:0030826)4.03791107
48regulation of pseudopodium assembly (GO:0031272)3.99210211
49multicellular organismal water homeostasis (GO:0050891)3.99199909
50regulation of vitamin metabolic process (GO:0030656)3.99058897
51drug metabolic process (GO:0017144)3.97075411
52fructose metabolic process (GO:0006000)3.96918792
53urea cycle (GO:0000050)3.96086147
54response to water (GO:0009415)3.87379926
55regulation of transforming growth factor beta1 production (GO:0032908)3.85768255
56urea metabolic process (GO:0019627)3.85626674
57renal filtration (GO:0097205)3.83236877
58complement activation, classical pathway (GO:0006958)3.83208926
59oligosaccharide biosynthetic process (GO:0009312)3.80929264
60digestive system process (GO:0022600)3.80764980
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.78889560
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.78889560
63surfactant homeostasis (GO:0043129)3.76278359
64negative regulation of keratinocyte proliferation (GO:0010839)3.75096060
65transepithelial transport (GO:0070633)3.74230013
66ventricular cardiac muscle cell action potential (GO:0086005)3.73906464
67antibacterial humoral response (GO:0019731)3.70536083
68digestion (GO:0007586)3.68691357
69keratinocyte proliferation (GO:0043616)3.67216537
70vitamin transmembrane transport (GO:0035461)3.66442801
71positive regulation of actin filament depolymerization (GO:0030836)3.65985412
72positive regulation of glycoprotein biosynthetic process (GO:0010560)3.65652452
73diacylglycerol metabolic process (GO:0046339)3.65566492
74regulation of chemokine secretion (GO:0090196)3.65327150
75protein autoprocessing (GO:0016540)3.61225605
76behavioral response to nicotine (GO:0035095)3.59778057
77antimicrobial humoral response (GO:0019730)3.57182398
78nitrogen cycle metabolic process (GO:0071941)3.55976900
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52816890
80norepinephrine metabolic process (GO:0042415)3.52325786
81adhesion of symbiont to host cell (GO:0044650)3.49378731
82virion attachment to host cell (GO:0019062)3.49378731
83nucleotide-sugar biosynthetic process (GO:0009226)3.48087487
84ethanol metabolic process (GO:0006067)3.45763545
85positive regulation of glycoprotein metabolic process (GO:1903020)3.41042136
86drug catabolic process (GO:0042737)3.39584701
87sperm capacitation (GO:0048240)3.38171259
88regulation of cholesterol homeostasis (GO:2000188)3.37831297
89arginine metabolic process (GO:0006525)3.37178112
90purine nucleotide salvage (GO:0032261)3.37035343
91nucleoside diphosphate biosynthetic process (GO:0009133)3.36935185
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36393013
93angiotensin maturation (GO:0002003)3.34624127
94membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.33345946
95water homeostasis (GO:0030104)3.32702519
96sympathetic nervous system development (GO:0048485)3.31671792
97glycolipid catabolic process (GO:0019377)3.31578366
98glycosphingolipid catabolic process (GO:0046479)3.29727316
99regulation of cGMP metabolic process (GO:0030823)3.29427667
100glutathione derivative biosynthetic process (GO:1901687)3.28379393
101glutathione derivative metabolic process (GO:1901685)3.28379393
102GDP-mannose metabolic process (GO:0019673)3.27813218
103transcytosis (GO:0045056)3.26809226
104sulfation (GO:0051923)3.23417438
105alkaloid metabolic process (GO:0009820)3.21080087
106peptide hormone processing (GO:0016486)3.20838434
107auditory receptor cell differentiation (GO:0042491)3.20543321
108very-low-density lipoprotein particle assembly (GO:0034379)3.20070687
109lung secretory cell differentiation (GO:0061140)3.19606177
110cGMP-mediated signaling (GO:0019934)3.18926862
111regulation of respiratory burst (GO:0060263)3.18103064
112peptide catabolic process (GO:0043171)3.17109076
113regulation of cardioblast differentiation (GO:0051890)3.15407880
114viral transcription (GO:0019083)3.15347337
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15001476
116galactose catabolic process (GO:0019388)3.14823660
117chemical homeostasis within a tissue (GO:0048875)3.14617654
118antigen processing and presentation of endogenous antigen (GO:0019883)3.14578311
119regulation of heart rate by cardiac conduction (GO:0086091)3.12132431
120sulfate transport (GO:0008272)3.10277525
121regulation of proton transport (GO:0010155)3.09056670
122hypotonic response (GO:0006971)3.08183137
123membrane repolarization during action potential (GO:0086011)3.07752678
124glandular epithelial cell differentiation (GO:0002067)3.07535144
125intestinal cholesterol absorption (GO:0030299)3.07430172
126nucleotide-sugar metabolic process (GO:0009225)3.07110271
127translational termination (GO:0006415)3.07088315
128complement activation (GO:0006956)3.06211358
129positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.05470749
130cyclooxygenase pathway (GO:0019371)3.04916194
131positive regulation of Cdc42 GTPase activity (GO:0043089)3.04564730
132fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03341347
133exogenous drug catabolic process (GO:0042738)3.03227676
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02159315
135bile acid metabolic process (GO:0008206)3.01605807
136vitamin transport (GO:0051180)3.00900889
137eosinophil chemotaxis (GO:0048245)3.00745869
138drug transport (GO:0015893)2.96161241
139sphingomyelin metabolic process (GO:0006684)2.95904875
140regulation of triglyceride catabolic process (GO:0010896)2.95820439
141renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.95649080
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.94736840
143sulfate transmembrane transport (GO:1902358)2.94308934
144adhesion of symbiont to host (GO:0044406)2.93602151
145positive regulation of fatty acid beta-oxidation (GO:0032000)2.93266641
146primary alcohol catabolic process (GO:0034310)2.92892745
147positive regulation of lipid catabolic process (GO:0050996)2.92850793
148drug transmembrane transport (GO:0006855)2.92663187
149kidney morphogenesis (GO:0060993)2.89131535
150bile acid and bile salt transport (GO:0015721)2.89082631
151phosphatidylserine acyl-chain remodeling (GO:0036150)2.85955603
152sodium ion homeostasis (GO:0055078)2.85607030
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85437478
154bicarbonate transport (GO:0015701)2.84344926
155positive regulation of protein localization to plasma membrane (GO:1903078)2.84189590
156glutamine family amino acid biosynthetic process (GO:0009084)2.82805924
157cytidine metabolic process (GO:0046087)2.82395602
158cytidine catabolic process (GO:0006216)2.82395602
159cytidine deamination (GO:0009972)2.82395602
160positive regulation of cGMP biosynthetic process (GO:0030828)2.81610219
161sulfur compound transport (GO:0072348)2.81407791
162regulation of secondary heart field cardioblast proliferation (GO:0003266)2.81074943
163regulation of cardioblast proliferation (GO:0003264)2.81074943
164protein targeting to ER (GO:0045047)2.80994180
165flavonoid metabolic process (GO:0009812)2.80542971
166cotranslational protein targeting to membrane (GO:0006613)2.79314296
167ribosomal small subunit assembly (GO:0000028)2.78605759
168cell differentiation involved in embryonic placenta development (GO:0060706)2.74147785
169positive regulation of interleukin-8 secretion (GO:2000484)2.73943199
170positive regulation of epidermal cell differentiation (GO:0045606)2.73742247
171protein O-linked glycosylation (GO:0006493)2.73240099
172viral life cycle (GO:0019058)2.71637395
173phosphatidylserine metabolic process (GO:0006658)2.70341827
174cellular protein complex disassembly (GO:0043624)2.69908133
175protein localization to endoplasmic reticulum (GO:0070972)2.69166475
176regulation of Golgi to plasma membrane protein transport (GO:0042996)2.68740561
177negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67840306
178cell communication involved in cardiac conduction (GO:0086065)2.66735900
179establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66710858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.32595151
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.65952057
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.38004783
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.97651970
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.89080100
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62807034
7* GATA4_25053715_ChIP-Seq_YYC3_Human3.52130267
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37846364
9* SOX2_20726797_ChIP-Seq_SW620_Human3.36957941
10ESR1_21235772_ChIP-Seq_MCF-7_Human3.17492112
11ZNF263_19887448_ChIP-Seq_K562_Human3.02905856
12ESR2_21235772_ChIP-Seq_MCF-7_Human3.00694054
13* GATA6_25053715_ChIP-Seq_YYC3_Human2.90302177
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.83664733
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.79937505
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.72197553
17* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.39625216
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.38273509
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35796291
20* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.31255465
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.29098611
22FOXO3_23340844_ChIP-Seq_DLD1_Human2.18220508
23* AR_21909140_ChIP-Seq_LNCAP_Human2.11527765
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.10353594
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.10353594
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10227730
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.05715740
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.03095475
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.98391536
30GATA3_24758297_ChIP-Seq_MCF-7_Human1.91933216
31KLF5_25053715_ChIP-Seq_YYC3_Human1.88715926
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.87723908
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87263715
34FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.82955917
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.82672670
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.82465140
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74519932
38ATF3_27146783_Chip-Seq_COLON_Human1.74428878
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70990125
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70495829
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70189276
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.66139941
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62934270
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61604704
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.59375115
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.58197068
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.57141759
48RACK7_27058665_Chip-Seq_MCF-7_Human1.56318983
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.55894045
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55379160
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53888879
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53425876
53GATA1_22025678_ChIP-Seq_K562_Human1.51401022
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49880562
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46885820
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.45942930
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44224437
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43587874
59LXR_22292898_ChIP-Seq_THP-1_Human1.42829137
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39842023
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38907988
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34152430
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30716453
64CJUN_26792858_Chip-Seq_BT549_Human1.29890099
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29741015
66* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27662098
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27184257
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26252154
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.24777655
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22513218
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.20947256
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19537165
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18108404
74* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16467435
75CLOCK_20551151_ChIP-Seq_293T_Human1.13799001
76* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11491017
77* FOXA1_25552417_ChIP-Seq_VCAP_Human1.10957163
78DROSHA_22980978_ChIP-Seq_HELA_Human1.09301983
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08879207
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03456156
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.02227106
82CDX2_22108803_ChIP-Seq_LS180_Human1.01512612
83CEBPB_22108803_ChIP-Seq_LS180_Human0.99919314
84ELF5_23300383_ChIP-Seq_T47D_Human0.99470269
85RXR_22158963_ChIP-Seq_LIVER_Mouse0.99125272
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98093355
87STAT1_20625510_ChIP-Seq_HELA_Human0.97930498
88* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97889324
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96748181
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94196979
91GATA1_19941826_ChIP-Seq_K562_Human0.92852618
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91032373
93CHD1_26751641_Chip-Seq_LNCaP_Human0.90430185
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90321333
95SA1_27219007_Chip-Seq_Bcells_Human0.89857129
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89750224
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89459142
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88601802
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88200881
100BCOR_27268052_Chip-Seq_Bcells_Human0.87730434
101TP63_23658742_ChIP-Seq_EP156T_Human0.87603484
102* GATA2_19941826_ChIP-Seq_K562_Human0.86592078
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86504880
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85615547
105BCL6_27268052_Chip-Seq_Bcells_Human0.85415206
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85091783
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84827109
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84104248
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83921978
110NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83491723
111BCAT_22108803_ChIP-Seq_LS180_Human0.82754678
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.82642664
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82408956
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82134948
115IRF8_21731497_ChIP-ChIP_J774_Mouse0.81941459
116NANOG_20526341_ChIP-Seq_ESCs_Human0.81305641
117RXR_22108803_ChIP-Seq_LS180_Human0.80992318
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80805295
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80005366
120CTCF_27219007_Chip-Seq_Bcells_Human0.79526903
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79044511
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78915378
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78823786
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.78823786
125* CREB1_26743006_Chip-Seq_LNCaP_Human0.78021334
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.77972568
127EGR1_19032775_ChIP-ChIP_M12_Human0.77702639
128AHR_22903824_ChIP-Seq_MCF-7_Human0.77641216
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75075425
130TP63_22573176_ChIP-Seq_HFKS_Human0.74676733
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74025922
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73521528
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73418030
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72942802
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.71494479
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68366997
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68265985
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68265985
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68249265
140SOX17_20123909_ChIP-Seq_XEN_Mouse0.67409480
141FOXA1_21572438_ChIP-Seq_LNCaP_Human0.66852236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.85410673
2MP0008004_abnormal_stomach_pH5.37506816
3MP0002822_catalepsy4.16146715
4MP0010386_abnormal_urinary_bladder3.46916362
5MP0004264_abnormal_extraembryonic_tissu3.44184057
6MP0000537_abnormal_urethra_morphology3.38676787
7MP0009379_abnormal_foot_pigmentation3.24676921
8MP0006054_spinal_hemorrhage3.13965241
9MP0000462_abnormal_digestive_system2.96978052
10MP0002796_impaired_skin_barrier2.90049140
11MP0001666_abnormal_nutrient_absorption2.83487642
12MP0001664_abnormal_digestion2.68846845
13MP0001873_stomach_inflammation2.67554649
14MP0000538_abnormal_urinary_bladder2.65817030
15MP0003866_abnormal_defecation2.40647818
16MP0005360_urolithiasis2.38649563
17MP0009840_abnormal_foam_cell2.29928393
18MP0005085_abnormal_gallbladder_physiolo2.26483919
19MP0010352_gastrointestinal_tract_polyps2.15773615
20MP0003941_abnormal_skin_development2.08028763
21MP0001663_abnormal_digestive_system2.00982193
22MP0003300_gastrointestinal_ulcer2.00255815
23MP0003868_abnormal_feces_composition1.97355898
24MP0005381_digestive/alimentary_phenotyp1.92251127
25MP0002876_abnormal_thyroid_physiology1.90828341
26MP0004782_abnormal_surfactant_physiolog1.87808934
27MP0005501_abnormal_skin_physiology1.85748349
28MP0000490_abnormal_crypts_of1.80330366
29MP0010678_abnormal_skin_adnexa1.79720752
30MP0010155_abnormal_intestine_physiology1.79299237
31MP0005166_decreased_susceptibility_to1.78019943
32MP0001756_abnormal_urination1.75687869
33MP0005409_darkened_coat_color1.66294677
34MP0003806_abnormal_nucleotide_metabolis1.65836899
35MP0000477_abnormal_intestine_morphology1.62462221
36MP0005408_hypopigmentation1.61411665
37MP0002098_abnormal_vibrissa_morphology1.50272830
38MP0010329_abnormal_lipoprotein_level1.49103326
39MP0009643_abnormal_urine_homeostasis1.46110891
40MP0004147_increased_porphyrin_level1.45648177
41MP0000470_abnormal_stomach_morphology1.42360271
42MP0005636_abnormal_mineral_homeostasis1.41551378
43MP0001765_abnormal_ion_homeostasis1.39163270
44MP0003693_abnormal_embryo_hatching1.37763319
45MP0005670_abnormal_white_adipose1.34405767
46MP0003724_increased_susceptibility_to1.34239784
47MP0004043_abnormal_pH_regulation1.34053651
48MP0004019_abnormal_vitamin_homeostasis1.33629862
49MP0001216_abnormal_epidermal_layer1.33517547
50MP0000465_gastrointestinal_hemorrhage1.29235076
51MP0008872_abnormal_physiological_respon1.27590431
52MP0008875_abnormal_xenobiotic_pharmacok1.26375606
53MP0000678_abnormal_parathyroid_gland1.25026195
54MP0000566_synostosis1.23774308
55MP0005083_abnormal_biliary_tract1.20942615
56MP0002060_abnormal_skin_morphology1.20074414
57MP0003453_abnormal_keratinocyte_physiol1.18790717
58MP0001764_abnormal_homeostasis1.17572669
59MP0002138_abnormal_hepatobiliary_system1.14171934
60MP0009785_altered_susceptibility_to1.09763279
61MP0004947_skin_inflammation1.08305212
62MP0003315_abnormal_perineum_morphology1.07929748
63MP0002132_abnormal_respiratory_system1.07703251
64MP0002277_abnormal_respiratory_mucosa1.07548885
65MP0002166_altered_tumor_susceptibility1.07304478
66MP0010771_integument_phenotype1.07264559
67MP0003705_abnormal_hypodermis_morpholog1.02567454
68MP0002139_abnormal_hepatobiliary_system1.02312051
69MP0002118_abnormal_lipid_homeostasis1.01838823
70MP0003656_abnormal_erythrocyte_physiolo1.00361616
71MP0005367_renal/urinary_system_phenotyp1.00175615
72MP0000516_abnormal_urinary_system1.00175615
73MP0001845_abnormal_inflammatory_respons0.99341310
74MP0001188_hyperpigmentation0.98557593
75MP0005275_abnormal_skin_tensile0.98405068
76MP0003191_abnormal_cellular_cholesterol0.98155356
77MP0003252_abnormal_bile_duct0.97315252
78MP0003303_peritoneal_inflammation0.95639389
79MP0009384_cardiac_valve_regurgitation0.93858557
80MP0002136_abnormal_kidney_physiology0.91884672
81MP0000609_abnormal_liver_physiology0.91847382
82MP0005319_abnormal_enzyme/_coenzyme0.90496865
83MP0003879_abnormal_hair_cell0.89254076
84MP0005025_abnormal_response_to0.88744821
85MP0000613_abnormal_salivary_gland0.86335861
86MP0003183_abnormal_peptide_metabolism0.85419735
87MP0009780_abnormal_chondrocyte_physiolo0.85113081
88MP0001849_ear_inflammation0.84343850
89MP0000230_abnormal_systemic_arterial0.83564730
90MP0000383_abnormal_hair_follicle0.83066173
91MP0002163_abnormal_gland_morphology0.82478170
92MP0002009_preneoplasia0.81647254
93MP0001501_abnormal_sleep_pattern0.80445361
94MP0003283_abnormal_digestive_organ0.79489677
95MP0005584_abnormal_enzyme/coenzyme_acti0.79269730
96MP0001790_abnormal_immune_system0.78872420
97MP0005387_immune_system_phenotype0.78872420
98MP0004270_analgesia0.78127916
99MP0003566_abnormal_cell_adhesion0.75933942
100MP0003436_decreased_susceptibility_to0.75477638
101MP0004484_altered_response_of0.74597881
102MP0005167_abnormal_blood-brain_barrier0.74202058
103MP0004957_abnormal_blastocyst_morpholog0.73625389
104MP0002896_abnormal_bone_mineralization0.73054511
105MP0002006_tumorigenesis0.72365082
106MP0004858_abnormal_nervous_system0.72035854
107MP0003950_abnormal_plasma_membrane0.71907545
108MP0002971_abnormal_brown_adipose0.71891856
109MP0006082_CNS_inflammation0.71795618
110MP0000627_abnormal_mammary_gland0.70254771
111MP0005310_abnormal_salivary_gland0.69949781
112MP0005165_increased_susceptibility_to0.69272445
113MP0003878_abnormal_ear_physiology0.68381569
114MP0005377_hearing/vestibular/ear_phenot0.68381569
115MP0008469_abnormal_protein_level0.68186316
116MP0000604_amyloidosis0.67702216
117MP0005448_abnormal_energy_balance0.67577889
118MP0005365_abnormal_bile_salt0.67068439
119MP0001986_abnormal_taste_sensitivity0.66714205
120MP0000762_abnormal_tongue_morphology0.66635498
121MP0003329_amyloid_beta_deposits0.66611710
122MP0000013_abnormal_adipose_tissue0.66515769
123MP0005451_abnormal_body_composition0.66489016
124MP0005666_abnormal_adipose_tissue0.66179951
125MP0005332_abnormal_amino_acid0.65026526
126MP0000377_abnormal_hair_follicle0.63967210
127MP0001958_emphysema0.63061171
128MP0002254_reproductive_system_inflammat0.62645082
129MP0001485_abnormal_pinna_reflex0.61325260
130MP0000467_abnormal_esophagus_morphology0.60515514
131MP0000249_abnormal_blood_vessel0.60514907
132MP0001533_abnormal_skeleton_physiology0.60381553
133MP0001191_abnormal_skin_condition0.59874764
134MP0009642_abnormal_blood_homeostasis0.59398434
135MP0005084_abnormal_gallbladder_morpholo0.58967496
136MP0001835_abnormal_antigen_presentation0.58558675
137MP0005535_abnormal_body_temperature0.58036145
138MP0001881_abnormal_mammary_gland0.57883502
139MP0004272_abnormal_basement_membrane0.55928911
140MP0002148_abnormal_hypersensitivity_rea0.55764774
141MP0009115_abnormal_fat_cell0.55314042
142MP0002751_abnormal_autonomic_nervous0.54801322
143MP0003045_fibrosis0.53987738
144MP0003119_abnormal_digestive_system0.53460845
145MP0002733_abnormal_thermal_nociception0.52992961
146MP0005187_abnormal_penis_morphology0.50857355

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.38651482
2Right ventricular cardiomyopathy (HP:0011663)6.23122074
3Abnormality of proline metabolism (HP:0010907)5.29837853
4Hydroxyprolinuria (HP:0003080)5.29837853
5Hyperactive renin-angiotensin system (HP:0000841)4.92545481
6Hypothermia (HP:0002045)4.77395025
7Abnormality of chloride homeostasis (HP:0011422)4.43480138
8Systemic lupus erythematosus (HP:0002725)4.40730966
9Onycholysis (HP:0001806)4.39493364
10Chronic diarrhea (HP:0002028)4.28108076
11Ventricular fibrillation (HP:0001663)4.24956811
12Woolly hair (HP:0002224)3.68204135
13Micronodular cirrhosis (HP:0001413)3.50452547
14Abdominal distention (HP:0003270)3.44230301
15Hypobetalipoproteinemia (HP:0003563)3.41985767
16Rectal prolapse (HP:0002035)3.40982492
17Malnutrition (HP:0004395)3.40095446
18Curly hair (HP:0002212)3.38484481
19Abnormal hemoglobin (HP:0011902)3.33245839
20Abnormal biliary tract morphology (HP:0012440)3.31871741
21Fragile nails (HP:0001808)3.22347512
22Abnormality of vitamin metabolism (HP:0100508)3.20974839
23Widely patent fontanelles and sutures (HP:0004492)3.15891787
24Pustule (HP:0200039)3.10894855
25Palpitations (HP:0001962)3.01685902
26Hemorrhage of the eye (HP:0011885)3.00057510
27Congenital sensorineural hearing impairment (HP:0008527)2.99381948
28Dehydration (HP:0001944)2.96592598
29Biliary tract neoplasm (HP:0100574)2.95835778
30Congenital ichthyosiform erythroderma (HP:0007431)2.94221454
31Milia (HP:0001056)2.83964009
32Conjugated hyperbilirubinemia (HP:0002908)2.83706663
33Confusion (HP:0001289)2.82371446
34Hypotension (HP:0002615)2.80345591
35Metabolic alkalosis (HP:0200114)2.78912238
36Glomerulonephritis (HP:0000099)2.78492555
37Glycosuria (HP:0003076)2.78306796
38Abnormality of urine glucose concentration (HP:0011016)2.78306796
39Pili torti (HP:0003777)2.76930412
40Plantar hyperkeratosis (HP:0007556)2.75662428
41Gastrointestinal dysmotility (HP:0002579)2.67221003
42Myopathic facies (HP:0002058)2.65980412
43Abnormality of cells of the erythroid lineage (HP:0012130)2.63883148
44Complement deficiency (HP:0004431)2.63582618
45Abnormality of complement system (HP:0005339)2.62597706
46Gout (HP:0001997)2.60381100
47Interstitial pulmonary disease (HP:0006530)2.60001690
48Eczematoid dermatitis (HP:0000976)2.58811432
49Pigmentary retinal degeneration (HP:0001146)2.58363946
50Abnormality of small intestinal villus morphology (HP:0011472)2.56658464
51Villous atrophy (HP:0011473)2.56658464
52Hyperammonemia (HP:0001987)2.55734093
53Syncope (HP:0001279)2.54973723
54Orthostatic hypotension (HP:0001278)2.52229529
55Hyponatremia (HP:0002902)2.50527434
56Abnormality of the gastric mucosa (HP:0004295)2.49060139
57Abnormality of renin-angiotensin system (HP:0000847)2.46806656
58Abnormal number of erythroid precursors (HP:0012131)2.39270436
59Steatorrhea (HP:0002570)2.38825024
60Xanthomatosis (HP:0000991)2.38521373
61Atrophic scars (HP:0001075)2.37512905
62Renal tubular acidosis (HP:0001947)2.36343185
63Hyperglycinuria (HP:0003108)2.36134831
64Wide cranial sutures (HP:0010537)2.34618649
65Abnormal autonomic nervous system physiology (HP:0012332)2.33281394
66Hyperparathyroidism (HP:0000843)2.32278798
67Abnormality of the nasal mucosa (HP:0000433)2.31388363
68Abnormality of potassium homeostasis (HP:0011042)2.30765111
69Nephritis (HP:0000123)2.29498855
70Hyperaldosteronism (HP:0000859)2.29223269
71Nausea (HP:0002018)2.27383086
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26684913
73Hyperphosphatemia (HP:0002905)2.26485205
74Potter facies (HP:0002009)2.24838891
75Facial shape deformation (HP:0011334)2.24838891
76Cheilitis (HP:0100825)2.24037540
77Nephrolithiasis (HP:0000787)2.23375595
78Focal segmental glomerulosclerosis (HP:0000097)2.22647315
79Fragile skin (HP:0001030)2.22403538
80Xerostomia (HP:0000217)2.21562865
81Hypoplasia of the uterus (HP:0000013)2.13789226
82Flat acetabular roof (HP:0003180)2.12863138
83Glomerulosclerosis (HP:0000096)2.12283403
84Microretrognathia (HP:0000308)2.12253887
85Renal salt wasting (HP:0000127)2.09547655
86Flattened epiphyses (HP:0003071)2.08235937
87Stenosis of the external auditory canal (HP:0000402)2.07419390
88Trismus (HP:0000211)2.07306493
89Abnormality of glycine metabolism (HP:0010895)2.07295779
90Abnormality of serine family amino acid metabolism (HP:0010894)2.07295779
91Abnormality of purine metabolism (HP:0004352)2.06498788
92Growth hormone excess (HP:0000845)2.06131966
93Vacuolated lymphocytes (HP:0001922)2.05904000
94Hyperphosphaturia (HP:0003109)2.05851507
95Hypophosphatemia (HP:0002148)2.05070229
96Lip pit (HP:0100267)2.04903384
97Thin bony cortex (HP:0002753)2.04390636
98Exocrine pancreatic insufficiency (HP:0001738)2.04246347
99Hypoplasia of dental enamel (HP:0006297)2.04152472
100Abnormality of magnesium homeostasis (HP:0004921)2.03910750
101Decreased circulating renin level (HP:0003351)2.03301189
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03278774
103Dicarboxylic aciduria (HP:0003215)2.03278774
104Posterior subcapsular cataract (HP:0007787)2.02511191
105Esophageal varix (HP:0002040)2.02273101
106Alkalosis (HP:0001948)2.01563747
107Nail dystrophy (HP:0008404)1.99839287
108Lipid accumulation in hepatocytes (HP:0006561)1.98794728
109Hypokalemia (HP:0002900)1.96403824
110Abnormal blistering of the skin (HP:0008066)1.95506077
111Cerebral palsy (HP:0100021)1.95239659
112Proximal tubulopathy (HP:0000114)1.94929959
113Abnormality of nucleobase metabolism (HP:0010932)1.94733140
114Conjunctival hamartoma (HP:0100780)1.94075008
115Popliteal pterygium (HP:0009756)1.93343523
116Nasal polyposis (HP:0100582)1.93111059
117Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91775915
118Abnormal pancreas size (HP:0012094)1.91454771
119Pancreatitis (HP:0001733)1.90628448
120Increased hepatocellular lipid droplets (HP:0006565)1.89708984
121Vascular calcification (HP:0004934)1.89599396
122Abnormality of the vitamin B12 metabolism (HP:0004341)1.88815842
123Abnormality of sodium homeostasis (HP:0010931)1.88243498
124Hyperkalemia (HP:0002153)1.88008696
125Symphalangism affecting the phalanges of the hand (HP:0009773)1.86603689
126Metabolic acidosis (HP:0001942)1.86318066
127Abnormal glucose tolerance (HP:0001952)1.85121788
128Protuberant abdomen (HP:0001538)1.85069337
129Goiter (HP:0000853)1.82773550
130Abnormality of carpal bone ossification (HP:0006257)1.82292077
131Neoplasm of the rectum (HP:0100743)1.81806594
132Uterine neoplasm (HP:0010784)1.81176328
133Chronic bronchitis (HP:0004469)1.81165317
134Congenital, generalized hypertrichosis (HP:0004540)1.80477148
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.80206656
136Macrocytic anemia (HP:0001972)1.78838557
137Abnormal tarsal ossification (HP:0008369)1.78528328
138Abnormality of pyrimidine metabolism (HP:0004353)1.78011277
139Abnormality of vitamin B metabolism (HP:0004340)1.77277005
140Increased purine levels (HP:0004368)1.77127160
141Hyperuricemia (HP:0002149)1.77127160
142Aplasia/hypoplasia of the uterus (HP:0008684)1.76824841
143Hepatic necrosis (HP:0002605)1.76716242
144Acanthocytosis (HP:0001927)1.75153629
145Fat malabsorption (HP:0002630)1.74821372
146Palmoplantar hyperkeratosis (HP:0000972)1.74374461
147Hoarse voice (HP:0001609)1.72861507
148Adrenal overactivity (HP:0002717)1.72675137
149Abnormal hair laboratory examination (HP:0003328)1.71949016
150Abnormal urine phosphate concentration (HP:0012599)1.71502025
151Intrahepatic cholestasis (HP:0001406)1.69803563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.89981850
2FRK5.19873705
3MST45.07756165
4EPHA24.52448244
5ERN13.67245751
6MST1R3.56129664
7NME12.86425170
8STK392.66965541
9MAP3K22.55522189
10TESK12.50243361
11MAP2K22.40031140
12PRKG22.13226235
13MAP3K101.95151756
14EPHB21.92669335
15MYLK1.77763000
16RPS6KB21.70357706
17OXSR11.66014214
18LIMK11.63340090
19MAP3K121.63219732
20MATK1.62246639
21FGFR41.58280881
22MAP2K11.54724915
23FER1.52023787
24NUAK11.44183750
25ERBB41.36863970
26MAP3K31.34473853
27PIK3CG1.33558211
28EPHA31.33508679
29MET1.30128477
30WNK41.29913580
31PTK61.27166241
32AKT31.26253706
33NTRK11.23789863
34TYK21.22293999
35MAP2K61.19694466
36EPHB11.17293115
37STK38L1.14040512
38LRRK21.11939381
39MAPKAPK31.11081959
40RIPK11.08970097
41TESK21.08418200
42PRKCI1.05510101
43SCYL21.05084796
44NEK91.04145334
45ERBB21.03017764
46NME21.00891845
47PAK41.00641690
48BRSK20.96621379
49GRK70.94367785
50MAP3K110.92412785
51STK240.90552709
52RIPK40.87747904
53FGFR30.86632644
54PTK20.86319189
55TAOK30.84767907
56PDK20.83399754
57STK100.83242969
58LATS10.78798120
59NLK0.77324221
60PRPF4B0.76479475
61PIK3CA0.73829379
62PDPK10.73304312
63CDC42BPA0.73281449
64PBK0.72056088
65BCR0.69916697
66KSR20.66749397
67TNIK0.65267214
68MAP4K10.64622032
69AURKB0.64126243
70MAPK110.63341303
71GRK10.62457776
72TRPM70.60280587
73PIM20.55936679
74TTN0.55530985
75PDK30.53274216
76PDK40.53274216
77CAMK2G0.52443432
78PRKACG0.51718050
79SMG10.51193611
80TBK10.51028774
81IRAK10.50284757
82BMPR20.49730065
83GRK60.47209392
84MAP3K80.47022826
85PDK10.46368491
86CAMK2D0.45535205
87PRKCE0.45027154
88ABL20.44298732
89CSK0.43836803
90MAP3K10.43086379
91ZAP700.42518278
92ARAF0.41995160
93JAK10.39762708
94MAPK150.39647554
95SRC0.39145307
96CAMK2B0.39062901
97TRIB30.38965971
98BMPR1B0.38848435
99NEK10.38247076
100DMPK0.36970448
101PRKCQ0.35358657
102PDGFRA0.35004793
103IRAK30.34402716
104STK30.34168308
105MAP3K140.33634187
106ADRBK10.33584024
107EPHA40.32392899
108DYRK1B0.32220542
109ILK0.32130622
110RPS6KA20.31101004
111TTK0.29426737
112GRK50.29254160
113PRKAA20.28530565
114MAPKAPK50.27915081
115RET0.27743365
116ROCK10.27586124
117PRKCZ0.26566500
118PRKCD0.26515654
119IKBKE0.25875272
120JAK20.25851406
121CAMKK20.25209971
122AURKA0.24925500
123EIF2AK10.24749743
124FYN0.24655288
125MAPKAPK20.23982352
126ACVR1B0.23682560
127NEK60.23206926
128CASK0.22550636
129BMX0.21580726
130YES10.21102201
131PRKAA10.20171818
132TAOK10.20146978
133TGFBR20.17810711
134IGF1R0.17481159
135BUB10.17343278
136RPS6KA40.17127839
137EEF2K0.16139542
138MELK0.15237975
139PAK10.15211906
140PRKCA0.14955288
141CDK60.14916452
142PAK30.13932573
143DAPK20.13797667
144DDR20.13391509
145CSNK1A10.12810339
146MAP3K70.11854411
147GSK3A0.11533134

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.66271556
2Mineral absorption_Homo sapiens_hsa049783.66842930
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.83289425
4Histidine metabolism_Homo sapiens_hsa003402.81658589
5Fat digestion and absorption_Homo sapiens_hsa049752.50000831
6Arginine biosynthesis_Homo sapiens_hsa002202.39970207
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.31296211
8Ribosome_Homo sapiens_hsa030102.22534184
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22086723
10Glutathione metabolism_Homo sapiens_hsa004802.19171452
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16722714
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08491878
13Tight junction_Homo sapiens_hsa045302.03211972
14Oxidative phosphorylation_Homo sapiens_hsa001902.00425165
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.80218684
16Folate biosynthesis_Homo sapiens_hsa007901.79578039
17Fructose and mannose metabolism_Homo sapiens_hsa000511.78052276
18Renin-angiotensin system_Homo sapiens_hsa046141.77295307
19Vibrio cholerae infection_Homo sapiens_hsa051101.74292477
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70190773
21Phenylalanine metabolism_Homo sapiens_hsa003601.68202976
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.67244721
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66393388
24Parkinsons disease_Homo sapiens_hsa050121.64716444
25Sphingolipid metabolism_Homo sapiens_hsa006001.63948986
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58391252
27Bile secretion_Homo sapiens_hsa049761.53345750
28Pancreatic secretion_Homo sapiens_hsa049721.49470442
29Thyroid cancer_Homo sapiens_hsa052161.47012279
30Tyrosine metabolism_Homo sapiens_hsa003501.40132973
31Alzheimers disease_Homo sapiens_hsa050101.33999583
32Protein digestion and absorption_Homo sapiens_hsa049741.32245274
33Arachidonic acid metabolism_Homo sapiens_hsa005901.31541672
34Nitrogen metabolism_Homo sapiens_hsa009101.28970140
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26750999
36Gastric acid secretion_Homo sapiens_hsa049711.26313799
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21764996
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21592572
39Tryptophan metabolism_Homo sapiens_hsa003801.21357297
40Bladder cancer_Homo sapiens_hsa052191.20461057
41Vitamin digestion and absorption_Homo sapiens_hsa049771.20080923
42Galactose metabolism_Homo sapiens_hsa000521.19630238
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19090195
44Proteasome_Homo sapiens_hsa030501.17939291
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16133200
46Chemical carcinogenesis_Homo sapiens_hsa052041.15926216
47Linoleic acid metabolism_Homo sapiens_hsa005911.15270558
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15074383
49Asthma_Homo sapiens_hsa053101.13833712
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.11663168
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09538529
52Adherens junction_Homo sapiens_hsa045201.09152551
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.09062976
54Caffeine metabolism_Homo sapiens_hsa002321.06956563
55Huntingtons disease_Homo sapiens_hsa050161.06229612
56Thyroid hormone synthesis_Homo sapiens_hsa049181.03601270
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.03201057
58Pentose phosphate pathway_Homo sapiens_hsa000301.01806236
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96764828
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96348940
61Fatty acid degradation_Homo sapiens_hsa000710.93189379
62Starch and sucrose metabolism_Homo sapiens_hsa005000.92010114
63Arginine and proline metabolism_Homo sapiens_hsa003300.90464694
64Staphylococcus aureus infection_Homo sapiens_hsa051500.89768502
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88824057
66Hepatitis C_Homo sapiens_hsa051600.86444102
67Allograft rejection_Homo sapiens_hsa053300.81775676
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79526757
69Autoimmune thyroid disease_Homo sapiens_hsa053200.76694224
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74265718
71N-Glycan biosynthesis_Homo sapiens_hsa005100.70838929
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70754650
73Graft-versus-host disease_Homo sapiens_hsa053320.70614193
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69820856
75Protein export_Homo sapiens_hsa030600.69030773
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.67892167
77ABC transporters_Homo sapiens_hsa020100.67655496
78Other glycan degradation_Homo sapiens_hsa005110.62525652
79Ether lipid metabolism_Homo sapiens_hsa005650.62154168
80Pyruvate metabolism_Homo sapiens_hsa006200.61976683
81Glycerolipid metabolism_Homo sapiens_hsa005610.61205997
82Collecting duct acid secretion_Homo sapiens_hsa049660.60353254
83Type I diabetes mellitus_Homo sapiens_hsa049400.57374231
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56987009
85Metabolic pathways_Homo sapiens_hsa011000.55908290
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54466165
87Peroxisome_Homo sapiens_hsa041460.53430975
88Fatty acid metabolism_Homo sapiens_hsa012120.51163371
89Retinol metabolism_Homo sapiens_hsa008300.50588544
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50018747
91Hippo signaling pathway_Homo sapiens_hsa043900.48765284
92Carbon metabolism_Homo sapiens_hsa012000.48194939
93Salmonella infection_Homo sapiens_hsa051320.47176655
94ECM-receptor interaction_Homo sapiens_hsa045120.45696494
95Cardiac muscle contraction_Homo sapiens_hsa042600.45516356
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43689579
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43608792
98Complement and coagulation cascades_Homo sapiens_hsa046100.40206904
99Endometrial cancer_Homo sapiens_hsa052130.38584117
100Renin secretion_Homo sapiens_hsa049240.37889719
101Antigen processing and presentation_Homo sapiens_hsa046120.37013667
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35550039
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.32495763
104Leishmaniasis_Homo sapiens_hsa051400.32385517
105Propanoate metabolism_Homo sapiens_hsa006400.32357185
106Salivary secretion_Homo sapiens_hsa049700.32291845
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32011233
108Insulin resistance_Homo sapiens_hsa049310.30763888
109beta-Alanine metabolism_Homo sapiens_hsa004100.30307307
110Fatty acid biosynthesis_Homo sapiens_hsa000610.30050441
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29963426
112Inositol phosphate metabolism_Homo sapiens_hsa005620.28954147
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.27630903
114Butanoate metabolism_Homo sapiens_hsa006500.25742674
115GnRH signaling pathway_Homo sapiens_hsa049120.25494815
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23371899
117Amoebiasis_Homo sapiens_hsa051460.22620896
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21375916
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.20867946
120Insulin secretion_Homo sapiens_hsa049110.17712806
121Sulfur relay system_Homo sapiens_hsa041220.17656651
122Small cell lung cancer_Homo sapiens_hsa052220.17571874
123Viral myocarditis_Homo sapiens_hsa054160.17023683
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16256945
125PPAR signaling pathway_Homo sapiens_hsa033200.14789145
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.14761203
127Pertussis_Homo sapiens_hsa051330.14734498
128Toxoplasmosis_Homo sapiens_hsa051450.11638889
129Influenza A_Homo sapiens_hsa051640.09049559
130Hematopoietic cell lineage_Homo sapiens_hsa046400.08605603
131African trypanosomiasis_Homo sapiens_hsa051430.08460355
132Biosynthesis of amino acids_Homo sapiens_hsa012300.05480299

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