TSPEAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a N-terminal thrombospondin-type laminin G domain and several tandem arranged epilepsy-associated repeats (EARs). A mutation in this gene is the cause of autosomal recessive deafness-98. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.27756567
2viral transcription (GO:0019083)8.27532941
3translational termination (GO:0006415)7.94823985
4maturation of SSU-rRNA (GO:0030490)7.24060803
5ribosomal small subunit biogenesis (GO:0042274)7.18709774
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.16672595
7cotranslational protein targeting to membrane (GO:0006613)7.04576478
8translational elongation (GO:0006414)7.01516284
9protein targeting to ER (GO:0045047)6.99931735
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.66943837
11DNA deamination (GO:0045006)6.65967615
12protein localization to endoplasmic reticulum (GO:0070972)6.53731422
13dorsal/ventral neural tube patterning (GO:0021904)6.45677994
14ribosomal large subunit biogenesis (GO:0042273)6.38282027
15viral life cycle (GO:0019058)6.27679078
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.15330113
17cellular protein complex disassembly (GO:0043624)6.14369149
18translational initiation (GO:0006413)5.70244500
19protein complex disassembly (GO:0043241)5.49899167
20histone H3-K36 demethylation (GO:0070544)5.47115496
21leukotriene biosynthetic process (GO:0019370)5.20736696
22histone H3-K9 demethylation (GO:0033169)5.15664582
23macromolecular complex disassembly (GO:0032984)5.15560687
24epithelial cell fate commitment (GO:0072148)4.92246011
25type B pancreatic cell development (GO:0003323)4.69646790
26protein targeting to membrane (GO:0006612)4.65430885
27establishment of integrated proviral latency (GO:0075713)4.57525431
28nuclear-transcribed mRNA catabolic process (GO:0000956)4.57010349
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.52871642
30mRNA catabolic process (GO:0006402)4.38151329
31leukotriene metabolic process (GO:0006691)4.36258986
32adrenergic receptor signaling pathway (GO:0071875)4.29301994
33translation (GO:0006412)4.24645293
34muscle organ morphogenesis (GO:0048644)4.23977604
35glandular epithelial cell development (GO:0002068)4.16551785
36DNA unwinding involved in DNA replication (GO:0006268)4.14561605
37cell junction maintenance (GO:0034331)4.10020622
38formation of translation preinitiation complex (GO:0001731)4.04429747
39RNA catabolic process (GO:0006401)4.04252481
40ribonucleoprotein complex biogenesis (GO:0022613)4.03976702
41IMP biosynthetic process (GO:0006188)3.98025084
42cell-cell junction maintenance (GO:0045217)3.93468480
43negative regulation of cAMP-mediated signaling (GO:0043951)3.91934586
44positive regulation of gastrulation (GO:2000543)3.88841563
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.88518133
46termination of RNA polymerase III transcription (GO:0006386)3.88518133
47establishment of viral latency (GO:0019043)3.85725304
48DNA strand elongation involved in DNA replication (GO:0006271)3.79454931
49peristalsis (GO:0030432)3.75342892
50ncRNA 3-end processing (GO:0043628)3.66879932
51mitochondrial DNA replication (GO:0006264)3.65083992
52embryonic retina morphogenesis in camera-type eye (GO:0060059)3.64323821
53hemidesmosome assembly (GO:0031581)3.63978891
54histone lysine demethylation (GO:0070076)3.60914761
55nucleotide transmembrane transport (GO:1901679)3.58726696
56intestinal cholesterol absorption (GO:0030299)3.57555645
57fat-soluble vitamin biosynthetic process (GO:0042362)3.55948507
58phosphatidylethanolamine biosynthetic process (GO:0006646)3.52366040
59histone demethylation (GO:0016577)3.49448246
60response to parathyroid hormone (GO:0071107)3.48320980
61DNA strand elongation (GO:0022616)3.48308600
62regulation of cholesterol metabolic process (GO:0090181)3.45407878
63DNA replication initiation (GO:0006270)3.45052187
64IMP metabolic process (GO:0046040)3.43239658
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.43014799
66definitive hemopoiesis (GO:0060216)3.42186029
67negative regulation of fibrinolysis (GO:0051918)3.33736781
68positive regulation of triglyceride lipase activity (GO:0061365)3.30675479
69positive regulation of lipoprotein lipase activity (GO:0051006)3.30675479
70hyperosmotic salinity response (GO:0042538)3.27021260
71rRNA processing (GO:0006364)3.26470136
72regulation of bile acid biosynthetic process (GO:0070857)3.25799243
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21631925
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21631925
75negative regulation of hormone biosynthetic process (GO:0032353)3.21509123
76respiratory chain complex IV assembly (GO:0008535)3.21413884
77establishment of protein localization to membrane (GO:0090150)3.20609161
78plasma lipoprotein particle clearance (GO:0034381)3.20381853
79protein carboxylation (GO:0018214)3.18304690
80peptidyl-glutamic acid carboxylation (GO:0017187)3.18304690
81cellular component biogenesis (GO:0044085)3.17516989
82cellular component maintenance (GO:0043954)3.17355584
83musculoskeletal movement (GO:0050881)3.17012742
84multicellular organismal movement (GO:0050879)3.17012742
85positive regulation of hormone biosynthetic process (GO:0046886)3.16960663
86rRNA metabolic process (GO:0016072)3.16552525
87outflow tract septum morphogenesis (GO:0003148)3.16445519
88negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.14541352
89respiratory system process (GO:0003016)3.12438047
90heart field specification (GO:0003128)3.10126107
91secondary heart field specification (GO:0003139)3.10126107
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09959277
93protein demethylation (GO:0006482)3.06978770
94protein dealkylation (GO:0008214)3.06978770
95phosphatidylethanolamine metabolic process (GO:0046337)3.04961329
96regulation of ARF GTPase activity (GO:0032312)3.04791318
97regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.00977455
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.99502370
99positive regulation of hormone metabolic process (GO:0032352)2.95145607
100blood coagulation, intrinsic pathway (GO:0007597)2.93725310
101positive regulation of receptor biosynthetic process (GO:0010870)2.92379229
102regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.90923068
103protein targeting (GO:0006605)2.90591208
104regulation of fibrinolysis (GO:0051917)2.86859638
105oocyte development (GO:0048599)2.85183401
106antigen processing and presentation of endogenous antigen (GO:0019883)2.83781017
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82915790
108negative regulation of hormone metabolic process (GO:0032351)2.81626166
109vitamin catabolic process (GO:0009111)2.81451953
110fat-soluble vitamin catabolic process (GO:0042363)2.81451953
111lung epithelium development (GO:0060428)2.81016436
112pseudouridine synthesis (GO:0001522)2.78206247
113regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.78071761
114dendritic spine organization (GO:0097061)2.75650241
115mitochondrial DNA metabolic process (GO:0032042)2.73833584
116telomere maintenance via semi-conservative replication (GO:0032201)2.73722193
117establishment of protein localization to organelle (GO:0072594)2.72396144
118lymphoid progenitor cell differentiation (GO:0002320)2.71583687
119pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.69051458
120primitive streak formation (GO:0090009)2.68126272
121signal transduction involved in regulation of gene expression (GO:0023019)2.67193101
122neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65781492
123columnar/cuboidal epithelial cell development (GO:0002066)2.65255172
124UTP biosynthetic process (GO:0006228)2.64856647
125phosphorelay signal transduction system (GO:0000160)2.64746739
126positive regulation of icosanoid secretion (GO:0032305)2.62058542
127apoptotic process involved in morphogenesis (GO:0060561)2.61098068
128fatty acid derivative biosynthetic process (GO:1901570)2.60663614
129icosanoid biosynthetic process (GO:0046456)2.60663614
130COPII vesicle coating (GO:0048208)2.60576766
131guanosine-containing compound biosynthetic process (GO:1901070)2.59601065
132peptidyl-lysine dimethylation (GO:0018027)2.59259200
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58331397
134protein localization to membrane (GO:0072657)2.57822630
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.55257369
136NADH dehydrogenase complex assembly (GO:0010257)2.55257369
137mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55257369
138DNA methylation involved in gamete generation (GO:0043046)2.54870632
139epithelial cell-cell adhesion (GO:0090136)2.53769750
140CTP biosynthetic process (GO:0006241)2.53503239
141CTP metabolic process (GO:0046036)2.53503239
142regulation of protein heterodimerization activity (GO:0043497)2.53091883
143pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52710239
144vitamin transmembrane transport (GO:0035461)2.52065533
145regulation of steroid hormone biosynthetic process (GO:0090030)2.51363285
146detection of molecule of bacterial origin (GO:0032490)2.51343388
147chemosensory behavior (GO:0007635)2.50857506
148negative regulation of cell size (GO:0045792)2.50338384
149positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.48220534
150pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.47464035
151peptide catabolic process (GO:0043171)2.47338837
152positive regulation of dendrite morphogenesis (GO:0050775)2.47002536
153L-fucose metabolic process (GO:0042354)2.46796117
154L-fucose catabolic process (GO:0042355)2.46796117
155fucose catabolic process (GO:0019317)2.46796117
156RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.46023390
157nucleobase biosynthetic process (GO:0046112)2.44801423
158pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.44226050
159regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44166547
160regulation of chromatin binding (GO:0035561)2.43150503
161spliceosomal snRNP assembly (GO:0000387)2.42707365
162GTP biosynthetic process (GO:0006183)2.42669659
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42606312
164carnitine shuttle (GO:0006853)2.42093071
165mating behavior (GO:0007617)2.41886584
166phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.41843756
167peptidyl-arginine omega-N-methylation (GO:0035247)2.41433703
168response to phenylpropanoid (GO:0080184)2.40361483
169histone mRNA metabolic process (GO:0008334)2.40117491
170somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39373441
171somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.39373441
172isotype switching (GO:0045190)2.39373441
173establishment of planar polarity (GO:0001736)2.39290181
174establishment of tissue polarity (GO:0007164)2.39290181
175cysteine metabolic process (GO:0006534)2.37657138
176histone H3-K4 trimethylation (GO:0080182)2.37332107
177plasma lipoprotein particle assembly (GO:0034377)2.36916690
178atrial septum morphogenesis (GO:0060413)2.36125750
179exocrine pancreas development (GO:0031017)2.35428981
180snRNA metabolic process (GO:0016073)2.35308500
181positive regulation of transcription regulatory region DNA binding (GO:2000679)2.35292208
182positive regulation of catenin import into nucleus (GO:0035413)2.35105799
183body morphogenesis (GO:0010171)2.33495186
184histone H4 deacetylation (GO:0070933)2.31348996
185unsaturated fatty acid biosynthetic process (GO:0006636)2.30612037
186fatty acid homeostasis (GO:0055089)2.29090931
187snRNA transcription (GO:0009301)2.28844435
188cellular modified amino acid catabolic process (GO:0042219)2.28661316
189cardiac myofibril assembly (GO:0055003)2.28410119
190regulation of cholesterol biosynthetic process (GO:0045540)2.28171301
191piRNA metabolic process (GO:0034587)2.28096320
192gonadal mesoderm development (GO:0007506)2.26999040
193positive regulation of insulin receptor signaling pathway (GO:0046628)2.26702128
194regulation of sarcomere organization (GO:0060297)2.26644445
195embryonic process involved in female pregnancy (GO:0060136)2.26632010
196pre-miRNA processing (GO:0031054)2.26169408
197regulation of water loss via skin (GO:0033561)2.25814475
198negative regulation of myotube differentiation (GO:0010832)2.24136927
199regulation of actin nucleation (GO:0051125)2.22878180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75958724
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.81909701
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.80863408
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.28329838
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.23207807
6EZH2_22144423_ChIP-Seq_EOC_Human4.17421444
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.45833453
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.33098499
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.15491372
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.15491372
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.15491372
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.14193625
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.94544441
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.92804953
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90853228
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.90123124
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88808158
18XRN2_22483619_ChIP-Seq_HELA_Human2.88599702
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.80027460
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75339619
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56274068
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.54531202
23DROSHA_22980978_ChIP-Seq_HELA_Human2.50111119
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.48516611
25MYC_22102868_ChIP-Seq_BL_Human2.36552272
26LXR_22292898_ChIP-Seq_THP-1_Human2.27067132
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26467432
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.24545067
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23159114
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21033263
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20397192
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16492224
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.13182406
34RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13125889
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11876285
36CIITA_25753668_ChIP-Seq_RAJI_Human2.11423898
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09418877
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.08363319
39FOXA2_19822575_ChIP-Seq_HepG2_Human2.05535292
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05336658
41SCL_19346495_ChIP-Seq_HPC-7_Human1.96173012
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94008351
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93618116
44VDR_23849224_ChIP-Seq_CD4+_Human1.93445724
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.92616200
46TCF7_22412390_ChIP-Seq_EML_Mouse1.92150033
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91264826
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.88593835
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88167382
50TTF2_22483619_ChIP-Seq_HELA_Human1.87706450
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85959485
52FOXP3_21729870_ChIP-Seq_TREG_Human1.83020913
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82158135
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81396311
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80506507
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78960072
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76969725
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72897441
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71608512
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70986362
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69652320
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.65876378
63RACK7_27058665_Chip-Seq_MCF-7_Human1.64520384
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63417516
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61504131
66SMC4_20622854_ChIP-Seq_HELA_Human1.60558920
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59561810
68VDR_21846776_ChIP-Seq_THP-1_Human1.58990121
69P68_20966046_ChIP-Seq_HELA_Human1.56186291
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.56066567
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54102519
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53728857
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.53099313
74KDM2B_26808549_Chip-Seq_K562_Human1.52079408
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51689395
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50074656
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49920500
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48152983
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.47886000
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45809625
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45321217
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43987602
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42848867
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42475412
85ELK1_19687146_ChIP-ChIP_HELA_Human1.42258532
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.40516764
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40435711
88DCP1A_22483619_ChIP-Seq_HELA_Human1.40187238
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39238956
90GATA1_22025678_ChIP-Seq_K562_Human1.38026475
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36116326
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35183934
93ELK1_22589737_ChIP-Seq_MCF10A_Human1.33837799
94GABP_19822575_ChIP-Seq_HepG2_Human1.33803021
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33704534
96CREB1_26743006_Chip-Seq_LNCaP_Human1.32395491
97KDM2B_26808549_Chip-Seq_DND41_Human1.31772956
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31190737
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29343369
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26865575
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26407089
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25986635
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24431957
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23619873
105UTX_26944678_Chip-Seq_JUKART_Human1.23519181
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22694581
107MYC_18940864_ChIP-ChIP_HL60_Human1.22438135
108CTCF_27219007_Chip-Seq_Bcells_Human1.21998430
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.21215919
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20666822
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20145701
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19863901
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19483634
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.19345453
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18942249
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18335631
117YY1_21170310_ChIP-Seq_MESCs_Mouse1.16815703
118SPI1_23547873_ChIP-Seq_NB4_Human1.16781674
119HNF4A_19822575_ChIP-Seq_HepG2_Human1.15386979
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.15104500
121E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14220869
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13389145
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12463074
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11704173
125LXR_22158963_ChIP-Seq_LIVER_Mouse1.11458417
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10455092
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09974110
128SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.09476866
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08669972
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06817564
131YY1_22570637_ChIP-Seq_MALME-3M_Human1.06779011
132OCT4_20526341_ChIP-Seq_ESCs_Human1.05649970
133NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05518072
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.04797920
135RARB_24833708_ChIP-Seq_LIVER_Mouse1.04130918
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04122621
137TP63_22573176_ChIP-Seq_HFKS_Human1.03984745
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03967213
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02665757
140TCF4_18268006_ChIP-ChIP_LS174T_Human1.01984487
141JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01550474
142OCT4_19829295_ChIP-Seq_ESCs_Human1.01330015
143E2F1_20622854_ChIP-Seq_HELA_Human1.01087585
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00785949
145MAF_26560356_Chip-Seq_TH1_Human1.00601659
146RAC3_21632823_ChIP-Seq_H3396_Human1.00094249
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99797339
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99415847
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98028090
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.97912114
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97315640
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.97097661
153VDR_24763502_ChIP-Seq_THP-1_Human0.96917075
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96675170
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.96437394
156PHF8_20622854_ChIP-Seq_HELA_Human0.95993438
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95795638
158BCOR_27268052_Chip-Seq_Bcells_Human0.95442894
159E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94623963
160KDM5A_27292631_Chip-Seq_BREAST_Human0.94331062
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94089470
162RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93972348
163EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93972348
164JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93844183
165RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93593362
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93496878
167SA1_27219007_Chip-Seq_ERYTHROID_Human0.92870653
168POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92711995
169CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92568299
170STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92169906
171BCL6_27268052_Chip-Seq_Bcells_Human0.91740056
172KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91608560
173OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90704871
174ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89992944
175E2F1_21310950_ChIP-Seq_MCF-7_Human0.89941351
176EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89826272
177MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89740895
178RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89399425
179MAF_26560356_Chip-Seq_TH2_Human0.89311090
180KDM2B_26808549_Chip-Seq_JURKAT_Human0.88564260
181CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88517230
182CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87730880
183TET1_21490601_ChIP-Seq_MESCs_Mouse0.87563456
184WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86599836
185YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86555571
186SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86398947
187POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85745296
188SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85447992
189MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85006229
190FOXP1_21924763_ChIP-Seq_HESCs_Human0.83387815
191IRF8_22096565_ChIP-ChIP_GC-B_Human0.83344811
192PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82913913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.14631181
2MP0005377_hearing/vestibular/ear_phenot5.14631181
3MP0000678_abnormal_parathyroid_gland4.59555840
4MP0009379_abnormal_foot_pigmentation3.90748534
5MP0003123_paternal_imprinting3.62237758
6MP0005409_darkened_coat_color3.60135691
7MP0003172_abnormal_lysosome_physiology3.48769047
8MP0003195_calcinosis3.45447937
9MP0005360_urolithiasis2.99772876
10MP0010352_gastrointestinal_tract_polyps2.85520838
11MP0002277_abnormal_respiratory_mucosa2.84188521
12MP0008007_abnormal_cellular_replicative2.80703087
13MP0002163_abnormal_gland_morphology2.77387995
14MP0005499_abnormal_olfactory_system2.72499431
15MP0005394_taste/olfaction_phenotype2.72499431
16MP0003693_abnormal_embryo_hatching2.61945422
17MP0002877_abnormal_melanocyte_morpholog2.60799991
18MP0005076_abnormal_cell_differentiation2.58037486
19MP0010030_abnormal_orbit_morphology2.50997300
20MP0002822_catalepsy2.48107661
21MP0008995_early_reproductive_senescence2.38075346
22MP0002751_abnormal_autonomic_nervous2.32323849
23MP0004510_myositis2.29526783
24MP0003879_abnormal_hair_cell2.25768938
25MP0005379_endocrine/exocrine_gland_phen2.17674374
26MP0003786_premature_aging2.13655132
27MP0005451_abnormal_body_composition2.06585097
28MP0008057_abnormal_DNA_replication1.97925144
29MP0003315_abnormal_perineum_morphology1.86937018
30MP0002396_abnormal_hematopoietic_system1.86453872
31MP0003077_abnormal_cell_cycle1.74232115
32MP0005310_abnormal_salivary_gland1.72824862
33MP0009780_abnormal_chondrocyte_physiolo1.72654302
34MP0000681_abnormal_thyroid_gland1.72063385
35MP0005365_abnormal_bile_salt1.70958659
36MP0004264_abnormal_extraembryonic_tissu1.69231793
37MP0000762_abnormal_tongue_morphology1.68628293
38MP0004133_heterotaxia1.67292469
39MP0010234_abnormal_vibrissa_follicle1.67235644
40MP0005220_abnormal_exocrine_pancreas1.67178444
41MP0002095_abnormal_skin_pigmentation1.65607056
42MP0001661_extended_life_span1.65358226
43MP0004858_abnormal_nervous_system1.64722363
44MP0006054_spinal_hemorrhage1.63585371
45MP0003111_abnormal_nucleus_morphology1.63570220
46MP0001346_abnormal_lacrimal_gland1.58135428
47MP0006292_abnormal_olfactory_placode1.54334177
48MP0005075_abnormal_melanosome_morpholog1.54070666
49MP0003763_abnormal_thymus_physiology1.53662592
50MP0003119_abnormal_digestive_system1.47013727
51MP0010094_abnormal_chromosome_stability1.45754187
52MP0001986_abnormal_taste_sensitivity1.44761893
53MP0003121_genomic_imprinting1.44516333
54MP0005501_abnormal_skin_physiology1.43924127
55MP0005645_abnormal_hypothalamus_physiol1.43506744
56MP0002098_abnormal_vibrissa_morphology1.43456547
57MP0005085_abnormal_gallbladder_physiolo1.42882120
58MP0002102_abnormal_ear_morphology1.41901092
59MP0008872_abnormal_physiological_respon1.41765020
60MP0002796_impaired_skin_barrier1.40539030
61MP0002060_abnormal_skin_morphology1.40311138
62MP0000470_abnormal_stomach_morphology1.39100159
63MP0006276_abnormal_autonomic_nervous1.38092714
64MP0003866_abnormal_defecation1.38057615
65MP0000685_abnormal_immune_system1.35239063
66MP0002166_altered_tumor_susceptibility1.34548020
67MP0004957_abnormal_blastocyst_morpholog1.31997511
68MP0000858_altered_metastatic_potential1.30088979
69MP0005666_abnormal_adipose_tissue1.28650769
70MP0002254_reproductive_system_inflammat1.26272354
71MP0000566_synostosis1.25277186
72MP0008877_abnormal_DNA_methylation1.25231298
73MP0001666_abnormal_nutrient_absorption1.21238598
74MP0010771_integument_phenotype1.20369653
75MP0004808_abnormal_hematopoietic_stem1.18085768
76MP0000428_abnormal_craniofacial_morphol1.17741574
77MP0009278_abnormal_bone_marrow1.16314053
78MP0010329_abnormal_lipoprotein_level1.14126561
79MP0005397_hematopoietic_system_phenotyp1.13878507
80MP0001545_abnormal_hematopoietic_system1.13878507
81MP0003566_abnormal_cell_adhesion1.13863362
82MP0001186_pigmentation_phenotype1.09897336
83MP0002398_abnormal_bone_marrow1.09788074
84MP0003656_abnormal_erythrocyte_physiolo1.09236290
85MP0001216_abnormal_epidermal_layer1.09228132
86MP0010630_abnormal_cardiac_muscle1.08761598
87MP0001835_abnormal_antigen_presentation1.08385178
88MP0000534_abnormal_ureter_morphology1.07131607
89MP0005410_abnormal_fertilization1.04948155
90MP0000427_abnormal_hair_cycle1.04702228
91MP0005647_abnormal_sex_gland1.02720354
92MP0002932_abnormal_joint_morphology1.01570836
93MP0001730_embryonic_growth_arrest1.01080482
94MP0002233_abnormal_nose_morphology1.01007442
95MP0009672_abnormal_birth_weight1.00622981
96MP0002108_abnormal_muscle_morphology0.99929346
97MP0000465_gastrointestinal_hemorrhage0.99275808
98MP0001853_heart_inflammation0.99129077
99MP0003122_maternal_imprinting0.98208336
100MP0002075_abnormal_coat/hair_pigmentati0.98156254
101MP0000613_abnormal_salivary_gland0.96108063
102MP0001502_abnormal_circadian_rhythm0.95858297
103MP0008260_abnormal_autophagy0.95411363
104MP0000015_abnormal_ear_pigmentation0.95392603
105MP0008961_abnormal_basal_metabolism0.95364761
106MP0002234_abnormal_pharynx_morphology0.94319432
107MP0004381_abnormal_hair_follicle0.94281651
108MP0000703_abnormal_thymus_morphology0.93356551
109MP0003942_abnormal_urinary_system0.92956540
110MP0001486_abnormal_startle_reflex0.92554774
111MP0002722_abnormal_immune_system0.92216041
112MP0001485_abnormal_pinna_reflex0.90919054
113MP0002909_abnormal_adrenal_gland0.90521594
114MP0003567_abnormal_fetal_cardiomyocyte0.90252366
115MP0002006_tumorigenesis0.89106782
116MP0002118_abnormal_lipid_homeostasis0.88975956
117MP0003698_abnormal_male_reproductive0.87712922
118MP0000689_abnormal_spleen_morphology0.87616261
119MP0003283_abnormal_digestive_organ0.87446998
120MP0003935_abnormal_craniofacial_develop0.87025847
121MP0002938_white_spotting0.86679734
122MP0000750_abnormal_muscle_regeneration0.85590289
123MP0004185_abnormal_adipocyte_glucose0.84898047
124MP0001929_abnormal_gametogenesis0.84236932
125MP0000313_abnormal_cell_death0.84012936
126MP0001800_abnormal_humoral_immune0.83585829
127MP0005058_abnormal_lysosome_morphology0.83409249
128MP0002693_abnormal_pancreas_physiology0.83384401
129MP0010155_abnormal_intestine_physiology0.82625547
130MP0006072_abnormal_retinal_apoptosis0.81782845
131MP0003787_abnormal_imprinting0.81579607
132MP0002019_abnormal_tumor_incidence0.81177321
133MP0000490_abnormal_crypts_of0.78753885
134MP0000516_abnormal_urinary_system0.78515543
135MP0005367_renal/urinary_system_phenotyp0.78515543
136MP0010678_abnormal_skin_adnexa0.78455880
137MP0000383_abnormal_hair_follicle0.77809889
138MP0008789_abnormal_olfactory_epithelium0.77150486
139MP0004043_abnormal_pH_regulation0.76865129
140MP0003890_abnormal_embryonic-extraembry0.76199730
141MP0002089_abnormal_postnatal_growth/wei0.76051078
142MP0001672_abnormal_embryogenesis/_devel0.75230270
143MP0005380_embryogenesis_phenotype0.75230270
144MP0002925_abnormal_cardiovascular_devel0.74324875
145MP0005375_adipose_tissue_phenotype0.74056869
146MP0000631_abnormal_neuroendocrine_gland0.73714748
147MP0003984_embryonic_growth_retardation0.73248094
148MP0005000_abnormal_immune_tolerance0.73157610
149MP0000716_abnormal_immune_system0.73079202
150MP0003183_abnormal_peptide_metabolism0.72575724
151MP0002084_abnormal_developmental_patter0.72340294
152MP0000477_abnormal_intestine_morphology0.72204208
153MP0002429_abnormal_blood_cell0.72204092
154MP0002249_abnormal_larynx_morphology0.71442980
155MP0002653_abnormal_ependyma_morphology0.71175650
156MP0002111_abnormal_tail_morphology0.70953287
157MP0009333_abnormal_splenocyte_physiolog0.70736033
158MP0010307_abnormal_tumor_latency0.70613932
159MP0003638_abnormal_response/metabolism_0.70488848
160MP0003943_abnormal_hepatobiliary_system0.70356972
161MP0002116_abnormal_craniofacial_bone0.70117969
162MP0005646_abnormal_pituitary_gland0.69920454
163MP0001944_abnormal_pancreas_morphology0.69845787
164MP0008004_abnormal_stomach_pH0.69628766
165MP0004084_abnormal_cardiac_muscle0.68944575
166MP0003115_abnormal_respiratory_system0.68289584
167MP0002088_abnormal_embryonic_growth/wei0.68267649
168MP0003868_abnormal_feces_composition0.67166192
169MP0009115_abnormal_fat_cell0.65906190
170MP0002161_abnormal_fertility/fecundity0.64624411
171MP0002086_abnormal_extraembryonic_tissu0.64250039
172MP0000767_abnormal_smooth_muscle0.63603016
173MP0004197_abnormal_fetal_growth/weight/0.63116633
174MP0004233_abnormal_muscle_weight0.62495186
175MP0000653_abnormal_sex_gland0.61990393
176MP0003705_abnormal_hypodermis_morpholog0.61698636
177MP0002127_abnormal_cardiovascular_syste0.61683491
178MP0002078_abnormal_glucose_homeostasis0.60151966
179MP0005334_abnormal_fat_pad0.59127928
180MP0002085_abnormal_embryonic_tissue0.58943856

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pubic bones (HP:0003172)5.29677375
2Deep venous thrombosis (HP:0002625)5.19834189
3Abnormality of cells of the erythroid lineage (HP:0012130)4.84550777
4Short humerus (HP:0005792)4.56069233
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.55574026
6Milia (HP:0001056)4.48847724
7Reticulocytopenia (HP:0001896)4.37238966
8Lip pit (HP:0100267)4.19814073
9Asplenia (HP:0001746)4.00609488
10Gonadotropin excess (HP:0000837)3.97385356
11Macrocytic anemia (HP:0001972)3.95456896
12Ridged nail (HP:0001807)3.93282676
13Aplastic anemia (HP:0001915)3.93191554
14Aplasia/hypoplasia of the humerus (HP:0006507)3.91571191
15Flat acetabular roof (HP:0003180)3.82559821
16Abnormal number of erythroid precursors (HP:0012131)3.81905735
17Pallor (HP:0000980)3.80881225
18Prolonged partial thromboplastin time (HP:0003645)3.75838456
19Dislocated radial head (HP:0003083)3.72980531
20Aplasia/Hypoplasia of the spleen (HP:0010451)3.72400334
21Genetic anticipation (HP:0003743)3.62571690
22Selective tooth agenesis (HP:0001592)3.60327766
23Abnormality of the radial head (HP:0003995)3.54773601
24Broad alveolar ridges (HP:0000187)3.52723611
25Severe visual impairment (HP:0001141)3.48770956
26Asymmetry of the thorax (HP:0001555)3.44591682
27IgM deficiency (HP:0002850)3.41191682
28Down-sloping shoulders (HP:0200021)3.29466253
29Ankyloglossia (HP:0010296)3.28151133
30Abnormality of the aortic arch (HP:0012303)3.25617614
31Generalized aminoaciduria (HP:0002909)3.17504155
32Aplasia/Hypoplasia of the scapulae (HP:0006713)3.13722316
33Hypoplastic scapulae (HP:0000882)3.13722316
34Congenital, generalized hypertrichosis (HP:0004540)3.06409081
35Abnormality of the humeroradial joint (HP:0100744)3.05984936
36Joint hemorrhage (HP:0005261)3.05948811
37Thrombocytosis (HP:0001894)2.97895545
38Preauricular pit (HP:0004467)2.97216109
39Periauricular skin pits (HP:0100277)2.97216109
40Fragile nails (HP:0001808)2.94132603
41Menorrhagia (HP:0000132)2.85906125
42Abnormality of oral frenula (HP:0000190)2.83959536
43Plantar hyperkeratosis (HP:0007556)2.83443537
44Abnormality of the humerus (HP:0003063)2.82270248
45Hypoglycemic seizures (HP:0002173)2.80926860
46Abnormality of the axillary hair (HP:0100134)2.77526981
47Abnormality of secondary sexual hair (HP:0009888)2.77526981
48Trismus (HP:0000211)2.75463716
49Abnormality of the upper arm (HP:0001454)2.74880294
50Stenosis of the external auditory canal (HP:0000402)2.74550573
51Hemorrhage of the eye (HP:0011885)2.70338212
52Germ cell neoplasia (HP:0100728)2.68283990
53Depressed nasal tip (HP:0000437)2.66896718
54Cerebral hypomyelination (HP:0006808)2.66617198
55Abnormality of abdominal situs (HP:0011620)2.66432326
56Abdominal situs inversus (HP:0003363)2.66432326
57Abnormal lung lobation (HP:0002101)2.64419847
58Dysmetric saccades (HP:0000641)2.64288793
59J-shaped sella turcica (HP:0002680)2.62836778
60Chronic otitis media (HP:0000389)2.62248724
61Sparse scalp hair (HP:0002209)2.58947564
62Flared iliac wings (HP:0002869)2.58038264
63Hyperparathyroidism (HP:0000843)2.57045255
64Testicular neoplasm (HP:0010788)2.55284682
65Gastrointestinal inflammation (HP:0004386)2.54871708
66Skin pits (HP:0100276)2.52329700
67Nail dystrophy (HP:0008404)2.49917219
68Abnormality of the columella (HP:0009929)2.46783304
69Lymphangioma (HP:0100764)2.45948671
70Gonadal dysgenesis (HP:0000133)2.45805604
71Woolly hair (HP:0002224)2.45469255
72Nausea (HP:0002018)2.45207570
73Pili torti (HP:0003777)2.45170889
74Abnormal number of incisors (HP:0011064)2.43185933
75Renal dysplasia (HP:0000110)2.42379171
76Colon cancer (HP:0003003)2.41516001
77Squamous cell carcinoma (HP:0002860)2.40540799
78Abnormality of calcium-phosphate metabolism (HP:0100530)2.40375076
79Hypercholesterolemia (HP:0003124)2.39672854
8011 pairs of ribs (HP:0000878)2.38967613
81Chronic sinusitis (HP:0011109)2.38885459
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38864893
83Abnormality of the fingertips (HP:0001211)2.38836651
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37497658
85Elevated erythrocyte sedimentation rate (HP:0003565)2.36896358
86Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35876554
87Anal stenosis (HP:0002025)2.35651049
88Basal cell carcinoma (HP:0002671)2.34973005
89Abnormality of endocrine pancreas physiology (HP:0012093)2.33015552
90Abnormality of the pancreatic islet cells (HP:0006476)2.33015552
91Midline defect of the nose (HP:0004122)2.31608337
92Skin tags (HP:0010609)2.31323180
93Palmar hyperkeratosis (HP:0010765)2.30962652
94Abnormality of the lumbar spine (HP:0100712)2.30252211
95Oral leukoplakia (HP:0002745)2.28458815
96Neoplasm of striated muscle (HP:0009728)2.27962825
97Abnormal trabecular bone morphology (HP:0100671)2.25539901
98Palmoplantar hyperkeratosis (HP:0000972)2.25269062
99Abnormal pancreas size (HP:0012094)2.22950905
100Sparse eyelashes (HP:0000653)2.22262965
101Abnormal hemoglobin (HP:0011902)2.21906285
102Onycholysis (HP:0001806)2.20906911
103Abnormality of the labia minora (HP:0012880)2.20441131
104Preauricular skin tag (HP:0000384)2.19835305
105Widely patent fontanelles and sutures (HP:0004492)2.19778291
106Right ventricular cardiomyopathy (HP:0011663)2.19544661
107Rhabdomyosarcoma (HP:0002859)2.19412636
108Broad ribs (HP:0000885)2.18752646
109Bifid tongue (HP:0010297)2.16994625
110Secondary amenorrhea (HP:0000869)2.16521281
111Thin bony cortex (HP:0002753)2.15405288
112High anterior hairline (HP:0009890)2.15194044
113Rough bone trabeculation (HP:0100670)2.13013593
114Poikiloderma (HP:0001029)2.10522369
115Facial hemangioma (HP:0000329)2.08458136
116Broad palm (HP:0001169)2.05981037
117Hepatoblastoma (HP:0002884)2.03810888
118Absent thumb (HP:0009777)2.03355405
119Hypophosphatemic rickets (HP:0004912)2.02768391
120Vaginal fistula (HP:0004320)2.02324408
121Microretrognathia (HP:0000308)2.01702495
122Abnormal sex determination (HP:0012244)2.00667654
123Sex reversal (HP:0012245)2.00667654
124Bicornuate uterus (HP:0000813)1.99919312
125Split foot (HP:0001839)1.99333214
126Growth hormone excess (HP:0000845)1.99003245
127Absent radius (HP:0003974)1.95591854
128Abnormality of the ischium (HP:0003174)1.94999595
129Type I transferrin isoform profile (HP:0003642)1.94134736
130Breast hypoplasia (HP:0003187)1.94079961
131Bilateral microphthalmos (HP:0007633)1.93569694
132Gingival bleeding (HP:0000225)1.92567322
133Abnormality of the thoracic spine (HP:0100711)1.92296685
134Mucopolysacchariduria (HP:0008155)1.91619770
135Urinary glycosaminoglycan excretion (HP:0003541)1.91619770
136CNS hypomyelination (HP:0003429)1.91260567
137Symptomatic seizures (HP:0011145)1.91151608
138Neoplasm of the adrenal cortex (HP:0100641)1.90702003
139Hypoplastic ischia (HP:0003175)1.90302414
140Vertebral arch anomaly (HP:0008438)1.89986420
141Choanal stenosis (HP:0000452)1.89231358
142Abnormal blistering of the skin (HP:0008066)1.89021948
143Enlarged penis (HP:0000040)1.88959366
144Increased mean platelet volume (HP:0011877)1.88827860
145Myelomeningocele (HP:0002475)1.87389442
146Atrophic scars (HP:0001075)1.86837297
147Abnormal platelet volume (HP:0011876)1.86383095
148Interstitial pulmonary disease (HP:0006530)1.86117760
149Hypoplasia of the odontoid process (HP:0003311)1.85910424
150Hypotrichosis (HP:0001006)1.85608341
151Heterotopia (HP:0002282)1.85243296
152Medulloblastoma (HP:0002885)1.83962955
153Diastasis recti (HP:0001540)1.83847258
154Intestinal fistula (HP:0100819)1.83776878
155Hypoplasia of the fovea (HP:0007750)1.83766202
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.83766202
157Skull defect (HP:0001362)1.82025627
158Late onset (HP:0003584)1.81009390
159Cerebellar dysplasia (HP:0007033)1.79514010
160Metaphyseal cupping (HP:0003021)1.78381715
161Short 4th metacarpal (HP:0010044)1.77359465
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77359465
163Dry hair (HP:0011359)1.76656121
164Ventricular tachycardia (HP:0004756)1.76591296
165Mesangial abnormality (HP:0001966)1.76494766
166Conjunctival hamartoma (HP:0100780)1.76343344
167Adenoma sebaceum (HP:0009720)1.75996051
168Angiofibromas (HP:0010615)1.75996051
169Deformed sella turcica (HP:0002681)1.75593910
170Visceral angiomatosis (HP:0100761)1.75135374
171Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74945994
172Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74945994
173Abnormality of polysaccharide metabolism (HP:0011012)1.74945994
174Migraine (HP:0002076)1.74655938
175Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72850028
176Abnormality of lateral ventricle (HP:0030047)1.72517406
177Aplasia involving forearm bones (HP:0009822)1.72074204
178Absent forearm bone (HP:0003953)1.72074204
179Progressive external ophthalmoplegia (HP:0000590)1.72039782
180Abnormality of subcutaneous fat tissue (HP:0001001)1.71868087
181Wide cranial sutures (HP:0010537)1.71266189
182Hypoglycemic coma (HP:0001325)1.70435404
183Cutaneous finger syndactyly (HP:0010554)1.69363251
184Atresia of the external auditory canal (HP:0000413)1.69088343
185Hypoalphalipoproteinemia (HP:0003233)1.68564714
186Abnormality of the nasal septum (HP:0000419)1.68559712
187Pancreatic islet-cell hyperplasia (HP:0004510)1.68401841
188Xanthomatosis (HP:0000991)1.67956547
189Abnormality of the phalanges of the hallux (HP:0010057)1.67665628
190Amelogenesis imperfecta (HP:0000705)1.67108593
191Truncal obesity (HP:0001956)1.67098610
192Hemangiomatosis (HP:0007461)1.66673553
193Fragile skin (HP:0001030)1.66164912
194Osteomalacia (HP:0002749)1.65198853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.33745995
2PKN23.99618154
3TSSK63.91052685
4CDK83.55915350
5NME23.53176154
6BUB13.37082038
7EPHB13.34972026
8PASK3.31335627
9FGFR43.25238099
10NME13.23640416
11CDK123.17266866
12RPS6KB22.92276459
13WEE12.85846014
14MAP4K12.54202722
15MAP3K122.52915767
16MAP3K72.52457758
17LATS12.50150157
18TGFBR12.39707062
19ADRBK22.35391509
20ICK2.27215052
21MAP3K32.24980829
22SIK32.14816264
23STK162.14705610
24SCYL21.96270410
25FGFR31.92386060
26DYRK1B1.89967837
27CDC71.81374875
28BTK1.80629169
29SIK21.76016906
30NEK91.74792186
31VRK11.73849002
32MAP2K31.64116506
33MARK21.61940574
34PINK11.61007049
35MAPKAPK31.61004620
36CDK71.60252234
37KIT1.49467630
38SMG11.41892951
39MAP3K101.39331082
40ERN11.39171347
41DAPK21.39160311
42FRK1.39087200
43TNK21.37671361
44ATR1.33522185
45RET1.32836719
46WNK11.32143007
47DMPK1.31923413
48INSRR1.31845457
49HIPK21.30979006
50NTRK31.30863987
51FLT31.27593762
52FGFR21.26443004
53WNK41.25908052
54MKNK11.25799096
55PAK41.24431479
56TLK11.24101242
57MET1.20301116
58GRK61.19247264
59CDC42BPA1.16711423
60TYK21.15703374
61RPS6KA41.14024406
62MKNK21.13006386
63EPHA21.09321243
64CDK41.09071188
65DAPK11.08809253
66RPS6KA21.08131548
67RPS6KA61.07426237
68FES1.07144332
69RPS6KC11.06656112
70RPS6KL11.06656112
71TEC1.05710984
72MTOR1.05710442
73PTK2B1.05600848
74MAPK111.04971345
75MAP3K111.00218361
76EEF2K0.99928320
77SIK10.93523726
78CDK60.93005273
79TAOK20.92327653
80PTK20.91313691
81IRAK40.90914522
82RIPK10.89622122
83CAMKK10.89005878
84MAPKAPK50.88021555
85AURKA0.84685814
86LRRK20.83652403
87PTK60.83360619
88CSF1R0.81060718
89STK380.80752817
90MAP3K60.79490751
91ACVR1B0.78938006
92BLK0.78779931
93PDPK10.77779180
94BRD40.77739952
95MAP3K20.77118850
96STK38L0.75798442
97CSNK2A20.74626782
98AURKB0.74454061
99PRKAA20.74013102
100DYRK1A0.73838917
101PRKAA10.73544413
102NLK0.73136465
103ILK0.71193056
104SYK0.69486698
105LATS20.69006194
106IRAK20.68834258
107CAMK1G0.67675909
108CHUK0.66814042
109DDR20.63589361
110MST1R0.62797997
111CAMK1D0.61224956
112ARAF0.60903082
113FGFR10.59816715
114CLK10.59128005
115NEK60.57677695
116PIM20.57650183
117BCKDK0.57218946
118PDGFRA0.56558702
119MAP2K40.54882430
120SGK2230.54246653
121SGK4940.54246653
122PRKD20.53988789
123NEK20.52980685
124PDK10.52179924
125TYRO30.51105527
126MAP3K40.51086352
127MATK0.50210146
128ADRBK10.49228188
129SGK30.48617482
130MAP2K70.48538849
131EPHA30.48221064
132RPS6KA10.47497851
133LYN0.47157848
134NEK10.46786907
135CSNK2A10.46050333
136TBK10.45785918
137TAOK10.44865028
138MELK0.44707345
139MAP3K10.44044755
140DYRK30.42468211
141ERBB20.41531967
142IKBKE0.41119838
143FGR0.40753068
144MAP2K20.39635737
145MUSK0.39210321
146MAPK10.39143543
147STK110.39057161
148RPS6KB10.38221463
149SGK20.38030065
150MAPK40.35822458
151PIM10.34595890
152CAMK40.34249036
153CDK190.32578091
154ZAP700.31938268
155PLK30.31593263
156PRKCI0.31447427
157ITK0.31241201
158PRPF4B0.30490828
159IRAK10.29153642
160KDR0.28565301
161MAP2K60.28324221
162PBK0.27113086
163RPS6KA50.26668693
164TIE10.26013974
165CDK20.25973330

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.68268747
2DNA replication_Homo sapiens_hsa030304.42859587
3Mismatch repair_Homo sapiens_hsa034304.00679645
4RNA polymerase_Homo sapiens_hsa030203.74130128
5Protein export_Homo sapiens_hsa030603.07087669
6Proteasome_Homo sapiens_hsa030503.00145158
7Spliceosome_Homo sapiens_hsa030402.58173403
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.51470871
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36907184
10Pyrimidine metabolism_Homo sapiens_hsa002402.28144838
11Lysine degradation_Homo sapiens_hsa003102.11534347
12RNA degradation_Homo sapiens_hsa030182.04331772
13RNA transport_Homo sapiens_hsa030132.03674404
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97715638
15Complement and coagulation cascades_Homo sapiens_hsa046101.97007943
16ABC transporters_Homo sapiens_hsa020101.87725782
17Homologous recombination_Homo sapiens_hsa034401.81412375
18Nucleotide excision repair_Homo sapiens_hsa034201.79552938
19Type II diabetes mellitus_Homo sapiens_hsa049301.78186221
20Non-homologous end-joining_Homo sapiens_hsa034501.72178783
21Cell cycle_Homo sapiens_hsa041101.62654320
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60789898
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.56314062
24Base excision repair_Homo sapiens_hsa034101.48725892
25mTOR signaling pathway_Homo sapiens_hsa041501.45943410
26Parkinsons disease_Homo sapiens_hsa050121.42817332
27Hedgehog signaling pathway_Homo sapiens_hsa043401.39734786
28Insulin signaling pathway_Homo sapiens_hsa049101.37562705
29Dorso-ventral axis formation_Homo sapiens_hsa043201.37452110
30Endometrial cancer_Homo sapiens_hsa052131.35472800
31Prolactin signaling pathway_Homo sapiens_hsa049171.35336911
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32414006
33VEGF signaling pathway_Homo sapiens_hsa043701.31875586
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.28294897
35Antigen processing and presentation_Homo sapiens_hsa046121.24218667
36AMPK signaling pathway_Homo sapiens_hsa041521.23337584
37Fatty acid degradation_Homo sapiens_hsa000711.20825206
38Oxidative phosphorylation_Homo sapiens_hsa001901.14934982
39Epstein-Barr virus infection_Homo sapiens_hsa051691.14479424
40N-Glycan biosynthesis_Homo sapiens_hsa005101.14290318
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12502273
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12472046
43Purine metabolism_Homo sapiens_hsa002301.12278955
44mRNA surveillance pathway_Homo sapiens_hsa030151.10490469
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10484740
46Insulin resistance_Homo sapiens_hsa049311.05403436
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.05302663
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04764046
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04615500
50Fatty acid metabolism_Homo sapiens_hsa012121.04433788
51Bile secretion_Homo sapiens_hsa049761.03425563
52One carbon pool by folate_Homo sapiens_hsa006701.01868910
53Basal cell carcinoma_Homo sapiens_hsa052171.00672589
54Wnt signaling pathway_Homo sapiens_hsa043100.99035594
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95231192
56Taste transduction_Homo sapiens_hsa047420.95050030
57Huntingtons disease_Homo sapiens_hsa050160.95006945
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.93336049
59PPAR signaling pathway_Homo sapiens_hsa033200.91554703
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91535796
61Fatty acid elongation_Homo sapiens_hsa000620.90891434
62Sphingolipid metabolism_Homo sapiens_hsa006000.90104273
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89576980
64Primary immunodeficiency_Homo sapiens_hsa053400.88943129
65Pentose phosphate pathway_Homo sapiens_hsa000300.87902673
66B cell receptor signaling pathway_Homo sapiens_hsa046620.87045897
67p53 signaling pathway_Homo sapiens_hsa041150.83955584
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82693228
69Arginine biosynthesis_Homo sapiens_hsa002200.80782647
70Fatty acid biosynthesis_Homo sapiens_hsa000610.80049941
71Inositol phosphate metabolism_Homo sapiens_hsa005620.79479236
72FoxO signaling pathway_Homo sapiens_hsa040680.79293471
73Fat digestion and absorption_Homo sapiens_hsa049750.78870027
74Folate biosynthesis_Homo sapiens_hsa007900.76586066
75Herpes simplex infection_Homo sapiens_hsa051680.74616160
76Thyroid cancer_Homo sapiens_hsa052160.72965398
77HTLV-I infection_Homo sapiens_hsa051660.72660270
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72517792
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72493880
80Choline metabolism in cancer_Homo sapiens_hsa052310.72068976
81Axon guidance_Homo sapiens_hsa043600.71527293
82Basal transcription factors_Homo sapiens_hsa030220.71034574
83Notch signaling pathway_Homo sapiens_hsa043300.70610884
84Legionellosis_Homo sapiens_hsa051340.70475791
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69639794
86Galactose metabolism_Homo sapiens_hsa000520.67899298
87Vitamin digestion and absorption_Homo sapiens_hsa049770.66520077
88Non-small cell lung cancer_Homo sapiens_hsa052230.64435254
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64426767
90Histidine metabolism_Homo sapiens_hsa003400.63880571
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62556170
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62277278
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61728436
94Butanoate metabolism_Homo sapiens_hsa006500.61334737
95Regulation of autophagy_Homo sapiens_hsa041400.60549097
96ErbB signaling pathway_Homo sapiens_hsa040120.60107966
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.60099053
98Hippo signaling pathway_Homo sapiens_hsa043900.56650670
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56292800
100Alzheimers disease_Homo sapiens_hsa050100.56233421
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54774925
102Estrogen signaling pathway_Homo sapiens_hsa049150.52064090
103TGF-beta signaling pathway_Homo sapiens_hsa043500.52024205
104Glutathione metabolism_Homo sapiens_hsa004800.51717752
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.51658880
106Hepatitis C_Homo sapiens_hsa051600.51316519
107Starch and sucrose metabolism_Homo sapiens_hsa005000.50081423
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49910538
109HIF-1 signaling pathway_Homo sapiens_hsa040660.49519375
110MicroRNAs in cancer_Homo sapiens_hsa052060.48487111
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48363824
112Steroid biosynthesis_Homo sapiens_hsa001000.47984153
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47779668
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46963116
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46584267
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46524106
117Adherens junction_Homo sapiens_hsa045200.46356857
118Bladder cancer_Homo sapiens_hsa052190.46337515
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45806613
120Dilated cardiomyopathy_Homo sapiens_hsa054140.45540153
121Proteoglycans in cancer_Homo sapiens_hsa052050.43993585
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43279840
123GnRH signaling pathway_Homo sapiens_hsa049120.41688342
124Colorectal cancer_Homo sapiens_hsa052100.41325553
125Small cell lung cancer_Homo sapiens_hsa052220.40452988
126Platelet activation_Homo sapiens_hsa046110.39943577
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39508297
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38744768
129Melanogenesis_Homo sapiens_hsa049160.38710645
130Tryptophan metabolism_Homo sapiens_hsa003800.38264905
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38264291
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.37493536
133Glucagon signaling pathway_Homo sapiens_hsa049220.36041478
134Glycerolipid metabolism_Homo sapiens_hsa005610.35573574
135Renin secretion_Homo sapiens_hsa049240.35400423
136Phenylalanine metabolism_Homo sapiens_hsa003600.34641202
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.34592917
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34524029
139Viral carcinogenesis_Homo sapiens_hsa052030.33491068
140Type I diabetes mellitus_Homo sapiens_hsa049400.33193094
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.32654890
142Pathways in cancer_Homo sapiens_hsa052000.29615297
143Leishmaniasis_Homo sapiens_hsa051400.29089083
144Shigellosis_Homo sapiens_hsa051310.27995266
145Other glycan degradation_Homo sapiens_hsa005110.27533643
146Prostate cancer_Homo sapiens_hsa052150.26753532
147Chronic myeloid leukemia_Homo sapiens_hsa052200.26584096
148Acute myeloid leukemia_Homo sapiens_hsa052210.25345907
149Cyanoamino acid metabolism_Homo sapiens_hsa004600.25162298
150Measles_Homo sapiens_hsa051620.24490251
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24269406
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24108894
153Pyruvate metabolism_Homo sapiens_hsa006200.23958487
154Hepatitis B_Homo sapiens_hsa051610.23439095
155Insulin secretion_Homo sapiens_hsa049110.22278616
156Ovarian steroidogenesis_Homo sapiens_hsa049130.22194257
157Oocyte meiosis_Homo sapiens_hsa041140.21118009
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19336764
159Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19048494
160Chemical carcinogenesis_Homo sapiens_hsa052040.18208282
161Metabolic pathways_Homo sapiens_hsa011000.17622242
162Alcoholism_Homo sapiens_hsa050340.17482833
163Apoptosis_Homo sapiens_hsa042100.16787787
164Cocaine addiction_Homo sapiens_hsa050300.15608871
165Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14554098
166Amphetamine addiction_Homo sapiens_hsa050310.14327232
167Dopaminergic synapse_Homo sapiens_hsa047280.13411034
168Central carbon metabolism in cancer_Homo sapiens_hsa052300.13314130
169Toxoplasmosis_Homo sapiens_hsa051450.12871033
170T cell receptor signaling pathway_Homo sapiens_hsa046600.12777825
171NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12405142
172Neurotrophin signaling pathway_Homo sapiens_hsa047220.11924281
173Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11630829

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »