TSPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.40694045
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09171783
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76332172
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76332172
5antigen processing and presentation of endogenous antigen (GO:0019883)4.46586759
6neutrophil activation involved in immune response (GO:0002283)4.21138315
7response to interferon-beta (GO:0035456)3.87752733
8detection of other organism (GO:0098543)3.84490517
9detection of bacterium (GO:0016045)3.82687833
10cellular response to type I interferon (GO:0071357)3.81410829
11type I interferon signaling pathway (GO:0060337)3.81410829
12response to type I interferon (GO:0034340)3.78042586
13barbed-end actin filament capping (GO:0051016)3.72855034
14immunoglobulin mediated immune response (GO:0016064)3.67394472
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67263908
16negative regulation of cell killing (GO:0031342)3.67263908
17positive regulation of protein homooligomerization (GO:0032464)3.61323754
18response to interferon-alpha (GO:0035455)3.59148670
19cellular response to interferon-beta (GO:0035458)3.57177593
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48339328
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.48339328
22modulation by symbiont of host immune response (GO:0052553)3.48339328
23positive regulation by symbiont of host defense response (GO:0052509)3.48339328
24modulation by symbiont of host defense response (GO:0052031)3.48339328
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48339328
26ribosomal small subunit assembly (GO:0000028)3.44922797
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40324779
28pinocytosis (GO:0006907)3.39897852
29proline biosynthetic process (GO:0006561)3.38015546
30regulation of mast cell degranulation (GO:0043304)3.34940251
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28440666
32positive regulation of interferon-alpha production (GO:0032727)3.20519748
33negative regulation of viral genome replication (GO:0045071)3.15998779
34B cell mediated immunity (GO:0019724)3.14163310
35negative regulation of erythrocyte differentiation (GO:0045647)3.13680514
36macrophage activation involved in immune response (GO:0002281)3.12764776
37detection of external biotic stimulus (GO:0098581)3.12475553
38positive regulation of natural killer cell differentiation (GO:0032825)3.11950625
39mature B cell differentiation involved in immune response (GO:0002313)3.11776290
40respiratory burst (GO:0045730)3.10433648
41antigen processing and presentation via MHC class Ib (GO:0002475)3.09132091
42response to peptidoglycan (GO:0032494)3.08560253
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03887396
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.02726307
45regulation of leukocyte degranulation (GO:0043300)3.02292815
46regulation of mast cell activation involved in immune response (GO:0033006)3.00430597
47regulation of interferon-alpha production (GO:0032647)2.99748341
48defense response to protozoan (GO:0042832)2.99131987
49neutrophil activation (GO:0042119)2.95513741
50positive regulation of antigen processing and presentation (GO:0002579)2.95496846
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94495940
52cellular extravasation (GO:0045123)2.92268338
53positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.91168242
54NIK/NF-kappaB signaling (GO:0038061)2.90183970
55telomere maintenance via semi-conservative replication (GO:0032201)2.88911236
56negative regulation of phagocytosis (GO:0050765)2.88851479
57positive regulation of lamellipodium assembly (GO:0010592)2.88660507
58granulocyte activation (GO:0036230)2.87219380
59amino sugar catabolic process (GO:0046348)2.82538726
60regulation of integrin activation (GO:0033623)2.82120535
61interferon-gamma-mediated signaling pathway (GO:0060333)2.80911789
62regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79803974
63regulation of T-helper 1 cell differentiation (GO:0045625)2.78081154
64embryonic process involved in female pregnancy (GO:0060136)2.78021241
65cellular response to virus (GO:0098586)2.77820789
66viral transcription (GO:0019083)2.77746542
67myeloid cell activation involved in immune response (GO:0002275)2.76373656
68response to protozoan (GO:0001562)2.75306645
69leukocyte mediated cytotoxicity (GO:0001909)2.73381872
70regulation of RIG-I signaling pathway (GO:0039535)2.72713179
71positive regulation of protein oligomerization (GO:0032461)2.72478386
72modulation of growth of symbiont involved in interaction with host (GO:0044144)2.71509695
73regulation of growth of symbiont in host (GO:0044126)2.71509695
74negative regulation of growth of symbiont in host (GO:0044130)2.71509695
75negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.71509695
76myeloid dendritic cell activation (GO:0001773)2.71400168
77natural killer cell mediated immunity (GO:0002228)2.71113272
78natural killer cell mediated cytotoxicity (GO:0042267)2.71113272
79regulation of antigen processing and presentation (GO:0002577)2.71042191
80sequestering of actin monomers (GO:0042989)2.69523861
81detection of biotic stimulus (GO:0009595)2.68976515
82reactive oxygen species biosynthetic process (GO:1903409)2.67140122
83positive regulation of B cell differentiation (GO:0045579)2.67014232
84T cell migration (GO:0072678)2.66102473
85regulation of superoxide anion generation (GO:0032928)2.65970413
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.65965458
87positive regulation of mast cell degranulation (GO:0043306)2.65965458
88positive regulation of interferon-beta production (GO:0032728)2.64732610
89myeloid dendritic cell differentiation (GO:0043011)2.63280396
90fibril organization (GO:0097435)2.63110723
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62870689
92response to host immune response (GO:0052572)2.62870689
93translational termination (GO:0006415)2.62312271
94positive regulation of gamma-delta T cell activation (GO:0046645)2.62275616
95positive regulation of monocyte chemotaxis (GO:0090026)2.61847219
96lipoxygenase pathway (GO:0019372)2.60283863
97regulation of hypersensitivity (GO:0002883)2.58545676
98negative regulation of interleukin-12 production (GO:0032695)2.57247540
99regulation of mononuclear cell migration (GO:0071675)2.57240933
100replication fork processing (GO:0031297)2.56806684
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55923602
102negative regulation of innate immune response (GO:0045824)2.55569609
103positive regulation of mast cell activation (GO:0033005)2.54316868
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.53876986
105regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53836238
106dendritic cell differentiation (GO:0097028)2.53094653
107negative regulation of cytokine production involved in immune response (GO:0002719)2.52844899
108positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52747010
109regulation of chemokine biosynthetic process (GO:0045073)2.52635824
110detection of molecule of bacterial origin (GO:0032490)2.52502131
111regulation of mast cell activation (GO:0033003)2.51313020
112positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51285975
113leukocyte aggregation (GO:0070486)2.51129241
114regulation of protein homooligomerization (GO:0032462)2.50645036
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50365479
116telomere maintenance via recombination (GO:0000722)2.50072892
117negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.49965674
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49208617
119response to host (GO:0075136)2.49208617
120response to host defenses (GO:0052200)2.49208617
121regulation of interferon-beta biosynthetic process (GO:0045357)2.47543145
122cellular response to exogenous dsRNA (GO:0071360)2.47090785
123pyrimidine nucleoside salvage (GO:0043097)2.46919074
124pyrimidine-containing compound salvage (GO:0008655)2.46919074
125proline metabolic process (GO:0006560)2.46732998
126negative regulation of myeloid cell apoptotic process (GO:0033033)2.46512350
127response to muramyl dipeptide (GO:0032495)2.46360996
128regulation of natural killer cell differentiation (GO:0032823)2.46096359
129cellular response to thyroid hormone stimulus (GO:0097067)2.45573295
130glycosphingolipid catabolic process (GO:0046479)2.45467438
131positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.45272542
132actin nucleation (GO:0045010)2.45235054
133negative regulation of interleukin-6 production (GO:0032715)2.45194502
134pentose-phosphate shunt (GO:0006098)2.45099497
135regulation of B cell receptor signaling pathway (GO:0050855)2.44385986
136regulation of activation of Janus kinase activity (GO:0010533)2.44070738
137positive regulation of T cell apoptotic process (GO:0070234)2.43555524
138transcription from mitochondrial promoter (GO:0006390)2.43458977
139T-helper 1 type immune response (GO:0042088)2.43120594
140regulation of monocyte chemotaxis (GO:0090025)2.42779774
141negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42674799
142* regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.42533328
143positive regulation of leukocyte degranulation (GO:0043302)2.41950499
144SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.41039428
145formation of translation preinitiation complex (GO:0001731)2.40885551
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.40858144
147macrophage differentiation (GO:0030225)2.39569202
148positive regulation of tumor necrosis factor production (GO:0032760)2.39283288
149positive regulation of lamellipodium organization (GO:1902745)2.39035804
150negative regulation of leukocyte mediated immunity (GO:0002704)2.38268673
151leukocyte degranulation (GO:0043299)2.37958930
152positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.37673183
153low-density lipoprotein particle clearance (GO:0034383)2.37355176
154negative regulation of granulocyte differentiation (GO:0030853)2.37197756
155regulation of macrophage chemotaxis (GO:0010758)2.36428216
156protein localization to endosome (GO:0036010)2.36153686
157positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34915790
158protein targeting to ER (GO:0045047)2.32153666
159DNA strand elongation involved in DNA replication (GO:0006271)2.31942438
160regulation of necroptotic process (GO:0060544)2.31668541
161cotranslational protein targeting to membrane (GO:0006613)2.30665569
162translational elongation (GO:0006414)2.30616670
163positive regulation of macrophage differentiation (GO:0045651)2.30120636
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.30043281
165leukocyte cell-cell adhesion (GO:0007159)2.28726770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.91166830
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.90061328
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15365123
4E2F7_22180533_ChIP-Seq_HELA_Human2.97962100
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92436095
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82739223
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.58863113
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57287340
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49963887
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.48891778
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41717682
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34666564
13* VDR_21846776_ChIP-Seq_THP-1_Human2.33045088
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26483673
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25965746
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15665527
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.13063395
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10914307
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04575143
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04416333
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.99201159
22SPI1_23547873_ChIP-Seq_NB4_Human1.96337419
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95191049
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90813266
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90236490
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.86036628
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77541693
28MAF_26560356_Chip-Seq_TH1_Human1.77371455
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76086303
30* VDR_24763502_ChIP-Seq_THP-1_Human1.70852579
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69689053
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69661030
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61535725
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.59798472
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59524457
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58663795
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58157255
38MYB_26560356_Chip-Seq_TH2_Human1.56887066
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55783828
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.53905655
41MYC_22102868_ChIP-Seq_BL_Human1.49949128
42RACK7_27058665_Chip-Seq_MCF-7_Human1.47369278
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47256799
44MYB_26560356_Chip-Seq_TH1_Human1.45046064
45SCL_19346495_ChIP-Seq_HPC-7_Human1.44368739
46GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44282143
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43129399
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39757174
49PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39561291
50* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38427342
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.38283394
52* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36438050
53BCOR_27268052_Chip-Seq_Bcells_Human1.35796401
54TCF7_22412390_ChIP-Seq_EML_Mouse1.35315785
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.34571508
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33332327
57KDM2B_26808549_Chip-Seq_DND41_Human1.32815465
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32612627
59UTX_26944678_Chip-Seq_JUKART_Human1.32346027
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30928349
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30382206
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30196807
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28989492
64* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27937261
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27881096
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27868390
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.27828421
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24738540
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24335752
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23980701
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.23904160
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.23341642
73MAF_26560356_Chip-Seq_TH2_Human1.23341021
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22597165
75* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22500537
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20851974
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19655089
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19564414
79P68_20966046_ChIP-Seq_HELA_Human1.18836459
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.17857512
81DCP1A_22483619_ChIP-Seq_HELA_Human1.17580222
82* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16395749
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16166306
84VDR_23849224_ChIP-Seq_CD4+_Human1.15363044
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.15356237
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14767308
87* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13664615
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13581250
89LXR_22292898_ChIP-Seq_THP-1_Human1.13513016
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13459014
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13292491
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12989792
93ZNF263_19887448_ChIP-Seq_K562_Human1.12381247
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12358083
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.12310427
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12301617
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11758260
98GATA1_22025678_ChIP-Seq_K562_Human1.11652131
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10307313
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.09823585
101* PU_27001747_Chip-Seq_BMDM_Mouse1.09471145
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09018031
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08756758
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08745675
105TFEB_21752829_ChIP-Seq_HELA_Human1.08590634
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06918031
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06838918
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06671828
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06657715
110EST1_17652178_ChIP-ChIP_JURKAT_Human1.06198744
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05899445
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05065451
113ETS1_20019798_ChIP-Seq_JURKAT_Human1.04220029
114* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03612128
115NCOR1_26117541_ChIP-Seq_K562_Human1.02603131
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02397870
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01776260
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00451217
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99552182
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99280049
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99260434
122* ATF3_27146783_Chip-Seq_COLON_Human0.99154228
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99016207
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.98954999
125PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97935426
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97007821
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96331398
128NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94946650
129BCL6_27268052_Chip-Seq_Bcells_Human0.94609405
130* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94509082
131XRN2_22483619_ChIP-Seq_HELA_Human0.93836043
132SPI1_23127762_ChIP-Seq_K562_Human0.93528042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03464479
2MP0000685_abnormal_immune_system3.39262866
3MP0009785_altered_susceptibility_to3.33526990
4MP0003436_decreased_susceptibility_to2.94491589
5MP0003724_increased_susceptibility_to2.85329581
6MP0002148_abnormal_hypersensitivity_rea2.83255136
7MP0002166_altered_tumor_susceptibility2.63639379
8MP0005025_abnormal_response_to2.62884558
9MP0005671_abnormal_response_to2.51238980
10MP0005000_abnormal_immune_tolerance2.36540814
11MP0002006_tumorigenesis2.33047964
12MP0002419_abnormal_innate_immunity2.29503613
13MP0005397_hematopoietic_system_phenotyp2.29013447
14MP0001545_abnormal_hematopoietic_system2.29013447
15MP0006082_CNS_inflammation2.28086440
16MP0005387_immune_system_phenotype2.26120439
17MP0001790_abnormal_immune_system2.26120439
18MP0003806_abnormal_nucleotide_metabolis2.24748996
19MP0001800_abnormal_humoral_immune2.10218533
20MP0002452_abnormal_antigen_presenting2.10184089
21MP0002723_abnormal_immune_serum2.04489002
22MP0001853_heart_inflammation2.03256849
23MP0001819_abnormal_immune_cell1.98838402
24MP0002420_abnormal_adaptive_immunity1.97691853
25MP0002405_respiratory_system_inflammati1.97679755
26MP0009278_abnormal_bone_marrow1.97361262
27MP0003300_gastrointestinal_ulcer1.90730022
28MP0008057_abnormal_DNA_replication1.87521806
29MP0005058_abnormal_lysosome_morphology1.82424664
30MP0009333_abnormal_splenocyte_physiolog1.81636090
31MP0003763_abnormal_thymus_physiology1.79602318
32MP0005464_abnormal_platelet_physiology1.79519411
33MP0008260_abnormal_autophagy1.79319531
34MP0010155_abnormal_intestine_physiology1.78841291
35MP0003186_abnormal_redox_activity1.75395713
36MP0002398_abnormal_bone_marrow1.71809044
37MP0005451_abnormal_body_composition1.70445315
38MP0002396_abnormal_hematopoietic_system1.69584729
39MP0003279_aneurysm1.63796470
40MP0000716_abnormal_immune_system1.63193524
41MP0003705_abnormal_hypodermis_morpholog1.59953862
42MP0001845_abnormal_inflammatory_respons1.59636060
43MP0000490_abnormal_crypts_of1.57796346
44MP0000343_altered_response_to1.55486482
45MP0000858_altered_metastatic_potential1.55141513
46MP0001542_abnormal_bone_strength1.54722777
47MP0003191_abnormal_cellular_cholesterol1.50431329
48MP0000689_abnormal_spleen_morphology1.49345500
49MP0001533_abnormal_skeleton_physiology1.47161272
50MP0005174_abnormal_tail_pigmentation1.44765876
51MP0002429_abnormal_blood_cell1.42412207
52MP0008469_abnormal_protein_level1.41268110
53MP0003448_altered_tumor_morphology1.41104924
54MP0002722_abnormal_immune_system1.40867007
55MP0001958_emphysema1.37531971
56MP0004947_skin_inflammation1.33166258
57MP0009764_decreased_sensitivity_to1.33152104
58MP0003303_peritoneal_inflammation1.32530393
59MP0000604_amyloidosis1.30962098
60MP0004510_myositis1.28703229
61MP0003172_abnormal_lysosome_physiology1.24346904
62MP0001873_stomach_inflammation1.23545877
63MP0003656_abnormal_erythrocyte_physiolo1.22317752
64MP0002009_preneoplasia1.22190024
65MP0005166_decreased_susceptibility_to1.21502589
66MP0005165_increased_susceptibility_to1.21088395
67MP0008438_abnormal_cutaneous_collagen1.19546567
68MP0001348_abnormal_lacrimal_gland1.19106698
69MP0002138_abnormal_hepatobiliary_system1.13017938
70MP0010352_gastrointestinal_tract_polyps1.12515348
71MP0002019_abnormal_tumor_incidence1.11855352
72MP0001851_eye_inflammation1.08198432
73MP0003828_pulmonary_edema1.01939974
74MP0003453_abnormal_keratinocyte_physiol1.01637069
75MP0003566_abnormal_cell_adhesion0.99963999
76MP0004782_abnormal_surfactant_physiolog0.97770448
77MP0003075_altered_response_to0.97633585
78MP0005075_abnormal_melanosome_morpholog0.96044738
79MP0009840_abnormal_foam_cell0.95267314
80MP0004883_abnormal_blood_vessel0.95018071
81MP0003866_abnormal_defecation0.92881111
82MP0010307_abnormal_tumor_latency0.92671088
83MP0004808_abnormal_hematopoietic_stem0.91510005
84MP0003795_abnormal_bone_structure0.91047711
85MP0009763_increased_sensitivity_to0.90404745
86MP0005023_abnormal_wound_healing0.90292000
87MP0002132_abnormal_respiratory_system0.89949667
88MP0002998_abnormal_bone_remodeling0.89674087
89MP0000703_abnormal_thymus_morphology0.88626634
90MP0005275_abnormal_skin_tensile0.86971155
91MP0002933_joint_inflammation0.86200596
92MP0003091_abnormal_cell_migration0.85801827
93MP0005257_abnormal_intraocular_pressure0.84561733
94MP0005076_abnormal_cell_differentiation0.83470507
95MP0009115_abnormal_fat_cell0.83311805
96MP0000371_diluted_coat_color0.83137099
97MP0004858_abnormal_nervous_system0.82036581
98MP0005310_abnormal_salivary_gland0.79509621
99MP0002796_impaired_skin_barrier0.79352406
100MP0005390_skeleton_phenotype0.79242332
101MP0006054_spinal_hemorrhage0.78544052
102MP0003329_amyloid_beta_deposits0.78217434
103MP0005164_abnormal_response_to0.77851711
104MP0003693_abnormal_embryo_hatching0.77439115
105MP0001663_abnormal_digestive_system0.77277248
106MP0001243_abnormal_dermal_layer0.73823810
107MP0005666_abnormal_adipose_tissue0.73624850
108MP0010094_abnormal_chromosome_stability0.73281997
109MP0000465_gastrointestinal_hemorrhage0.73149196
110MP0004185_abnormal_adipocyte_glucose0.73003107
111MP0000249_abnormal_blood_vessel0.72786593
112MP0003183_abnormal_peptide_metabolism0.72113258
113MP0005319_abnormal_enzyme/_coenzyme0.71790871
114MP0008004_abnormal_stomach_pH0.71440736
115MP0002060_abnormal_skin_morphology0.70893463
116MP0003786_premature_aging0.68671344
117MP0000015_abnormal_ear_pigmentation0.68389673
118MP0001849_ear_inflammation0.68167457
119MP0000750_abnormal_muscle_regeneration0.67929268
120MP0000609_abnormal_liver_physiology0.67371985
121MP0005584_abnormal_enzyme/coenzyme_acti0.67116351
122MP0008007_abnormal_cellular_replicative0.66144238
123MP0002163_abnormal_gland_morphology0.64217758
124MP0000598_abnormal_liver_morphology0.63192581
125MP0003077_abnormal_cell_cycle0.61370871
126MP0002877_abnormal_melanocyte_morpholog0.60539132
127MP0004957_abnormal_blastocyst_morpholog0.59635363
128MP0002254_reproductive_system_inflammat0.59225291
129MP0005670_abnormal_white_adipose0.58740564

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.01156987
2Abnormality of glycolipid metabolism (HP:0010969)4.95152231
3Abnormality of liposaccharide metabolism (HP:0010968)4.95152231
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.95152231
5Increased IgM level (HP:0003496)4.85226541
6Recurrent abscess formation (HP:0002722)4.78339891
7Eczematoid dermatitis (HP:0000976)4.67336086
8Pustule (HP:0200039)4.35862796
9Recurrent bacterial skin infections (HP:0005406)4.25958965
10Myositis (HP:0100614)3.76867846
11Autoimmune thrombocytopenia (HP:0001973)3.51375701
12Recurrent gram-negative bacterial infections (HP:0005420)3.42139766
13Thrombocytosis (HP:0001894)3.40530620
14Recurrent fungal infections (HP:0002841)3.37990162
15Chronic otitis media (HP:0000389)3.34400486
16Hypergammaglobulinemia (HP:0010702)3.28775773
17Increased cerebral lipofuscin (HP:0011813)3.25633149
18Amyloidosis (HP:0011034)3.23069382
19Abnormality of macrophages (HP:0004311)3.20542040
20Abnormality of T cell physiology (HP:0011840)3.19660057
21Mediastinal lymphadenopathy (HP:0100721)3.07816538
22Hepatosplenomegaly (HP:0001433)2.99787229
23Abnormal number of erythroid precursors (HP:0012131)2.97366863
24Recurrent skin infections (HP:0001581)2.96719382
25Poikiloderma (HP:0001029)2.96391872
26Petechiae (HP:0000967)2.92946689
27Vacuolated lymphocytes (HP:0001922)2.91710549
28Loss of speech (HP:0002371)2.91703745
29Abnormality of cells of the erythroid lineage (HP:0012130)2.89531108
30Orchitis (HP:0100796)2.88208955
31Nasal polyposis (HP:0100582)2.73103277
32Obstructive lung disease (HP:0006536)2.72755805
33Chronic obstructive pulmonary disease (HP:0006510)2.72755805
34Premature rupture of membranes (HP:0001788)2.71858217
35Abnormality of the nasal mucosa (HP:0000433)2.71019213
36Vasculitis (HP:0002633)2.68246071
37Urinary glycosaminoglycan excretion (HP:0003541)2.65613346
38Mucopolysacchariduria (HP:0008155)2.65613346
39Recurrent bronchitis (HP:0002837)2.64842060
40Abnormality of T cells (HP:0002843)2.62623302
41Recurrent viral infections (HP:0004429)2.62396692
42Albinism (HP:0001022)2.59424010
43IgA deficiency (HP:0002720)2.56587532
44Basal ganglia calcification (HP:0002135)2.56101219
45Dysostosis multiplex (HP:0000943)2.53189253
46Interstitial pulmonary disease (HP:0006530)2.52430593
47IgG deficiency (HP:0004315)2.51572252
48Exertional dyspnea (HP:0002875)2.51344779
49Chronic mucocutaneous candidiasis (HP:0002728)2.49858682
50Recurrent cutaneous fungal infections (HP:0011370)2.49858682
51Systemic lupus erythematosus (HP:0002725)2.48519186
52IgM deficiency (HP:0002850)2.46789865
53Gingivitis (HP:0000230)2.44104302
54Periodontitis (HP:0000704)2.42246356
55Protrusio acetabuli (HP:0003179)2.40926380
56Distal lower limb muscle weakness (HP:0009053)2.39706939
57Abnormal hemoglobin (HP:0011902)2.38444281
58Vertebral compression fractures (HP:0002953)2.38116055
59Urticaria (HP:0001025)2.35379917
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35082357
61Abnormality of polysaccharide metabolism (HP:0011012)2.35082357
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35082357
63Hypertensive crisis (HP:0100735)2.31407650
64Meningitis (HP:0001287)2.30105019
65Optic neuritis (HP:0100653)2.27877234
66Retrobulbar optic neuritis (HP:0100654)2.27877234
67Autoimmune hemolytic anemia (HP:0001890)2.27763446
68Hypertriglyceridemia (HP:0002155)2.25499670
69Reticulocytopenia (HP:0001896)2.24313496
70Progressive neurologic deterioration (HP:0002344)2.23355488
71Reduced antithrombin III activity (HP:0001976)2.21283195
72Gastrointestinal infarctions (HP:0005244)2.19602623
73Epistaxis (HP:0000421)2.18935300
74Stomatitis (HP:0010280)2.18481070
75Cellulitis (HP:0100658)2.18408588
76Hypochromic anemia (HP:0001931)2.17438650
77Prolonged bleeding time (HP:0003010)2.16077494
78Spondylolisthesis (HP:0003302)2.15185673
79Cheilitis (HP:0100825)2.14706005
80Recurrent lower respiratory tract infections (HP:0002783)2.13811591
81Purpura (HP:0000979)2.11752351
82Inflammation of the large intestine (HP:0002037)2.09086222
83Abnormality of the prostate (HP:0008775)2.08847916
84Skin ulcer (HP:0200042)2.08681491
85Peritonitis (HP:0002586)2.07908485
86Hemoptysis (HP:0002105)2.06517495
87Leukocytosis (HP:0001974)2.05246330
88Poor head control (HP:0002421)2.04328250
89Abnormality of iron homeostasis (HP:0011031)2.04309054
90Upper motor neuron abnormality (HP:0002127)2.03104041
91Abnormality of male internal genitalia (HP:0000022)2.02922772
92Joint stiffness (HP:0001387)2.02656544
93Gastrointestinal inflammation (HP:0004386)2.02360116
94Polygenic inheritance (HP:0010982)2.02188653
95Colitis (HP:0002583)2.02049702
96Prolonged neonatal jaundice (HP:0006579)2.01969208
97Alopecia of scalp (HP:0002293)2.01353739
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.00895750
99Polycythemia (HP:0001901)1.99661949
100Microcytic anemia (HP:0001935)1.97303703
101Abnormality of T cell number (HP:0011839)1.96563005
102Myocardial infarction (HP:0001658)1.93436058
103Spontaneous hematomas (HP:0007420)1.93296475
104Muscle fiber atrophy (HP:0100295)1.92145376
105Anorexia (HP:0002039)1.92104355
106Gingival bleeding (HP:0000225)1.91793346
107Pulmonary infiltrates (HP:0002113)1.91336894
108Abnormality of cells of the lymphoid lineage (HP:0012140)1.90875359
109Increased serum ferritin (HP:0003281)1.88842753
110Tetraparesis (HP:0002273)1.88745133
111Asymmetric septal hypertrophy (HP:0001670)1.88184062
112Increased neuronal autofluorescent lipopigment (HP:0002074)1.88088312
113Chest pain (HP:0100749)1.87651022
114Eosinophilia (HP:0001880)1.85163884
115Increased IgE level (HP:0003212)1.85076262
116Granulocytopenia (HP:0001913)1.84492537
117Nausea (HP:0002018)1.83850327
118Abnormal platelet volume (HP:0011876)1.82852841
119Glomerulopathy (HP:0100820)1.82123291
120Axonal loss (HP:0003447)1.81779778
121Increased connective tissue (HP:0009025)1.81575476
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80481355
123Type I transferrin isoform profile (HP:0003642)1.80181663
124Cervical subluxation (HP:0003308)1.79685897
125Episodic fever (HP:0001954)1.78592652
126Abnormality of the pericardium (HP:0001697)1.78311086
127Atrophic scars (HP:0001075)1.76010377
128Reduced subcutaneous adipose tissue (HP:0003758)1.75333597
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.75018359
130Osteolytic defects of the hand bones (HP:0009699)1.75018359
131Premature loss of primary teeth (HP:0006323)1.70168137
132Abnormality of complement system (HP:0005339)1.68105680
133Dilatation of the ascending aorta (HP:0005111)1.68026211
134Nuclear cataract (HP:0100018)1.67131685
135Encephalitis (HP:0002383)1.66246185
136Osteomyelitis (HP:0002754)1.65588835
137Skin rash (HP:0000988)1.65517376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM23.90287357
2NME22.92483131
3TBK12.74369028
4TYK22.59241056
5MAP3K142.47849851
6BLK2.46138104
7MAP4K12.33739106
8JAK32.24277928
9MAP3K112.22658923
10KIT2.21170525
11IKBKE2.16397286
12ERN12.11103649
13IRAK42.01231766
14PRPF4B1.98869139
15MATK1.93945346
16IKBKB1.93644156
17CSK1.83436302
18MAP3K61.77294681
19PIM11.70078177
20KDR1.66347324
21ZAP701.62388775
22MAPK151.59298886
23TEC1.57157036
24TRPM71.56335023
25GRK61.51259228
26DDR21.50585481
27RPS6KA41.45768849
28LIMK11.45249034
29FES1.45125476
30TESK21.41282977
31TXK1.40736826
32BTK1.38852953
33MOS1.35479442
34BMX1.29210836
35PBK1.29006569
36IRAK31.27536674
37FLT31.27442337
38TAOK11.25192014
39JAK11.22863888
40TESK11.19996488
41MAP2K31.18113483
42LRRK21.11066830
43VRK21.09847644
44LYN1.09824721
45GRK71.08494666
46DAPK11.08453030
47SYK1.06641995
48YES11.06278082
49TRIB31.05483382
50FGFR41.03603646
51DYRK1B1.03527784
52SIK11.02871423
53TNK21.02794616
54CDK61.02482183
55ICK1.00368439
56CHUK1.00133712
57SMG10.99284296
58NEK90.97618867
59MAP3K10.97029919
60ABL20.96429876
61RIPK40.93891639
62LCK0.92767504
63MAP3K130.92264726
64EPHA20.91866297
65STK100.89593805
66MAPK110.88936198
67TTN0.88573647
68EIF2AK30.88234594
69ACVR1B0.87437291
70CDK70.87054804
71MAPKAPK30.87041222
72BCKDK0.86480664
73STK160.86443487
74CSF1R0.84889500
75RPS6KA60.84668517
76TGFBR20.83866936
77EIF2AK10.80700680
78FGR0.74952751
79RPS6KL10.73376770
80RPS6KC10.73376770
81JAK20.73167232
82EIF2AK20.73077721
83EPHB20.72983516
84PINK10.72379904
85MST40.70508737
86STK40.70214525
87DYRK30.67916066
88PDPK10.67332809
89SCYL20.65805389
90HCK0.65300666
91CDC42BPA0.65256857
92TGFBR10.64099460
93PRKG20.62899670
94PAK40.61122451
95PTK60.59102620
96MAP3K30.58485427
97DAPK30.57823406
98MAPKAPK20.57239691
99TAOK20.57051820
100LMTK20.56218054
101PRKCD0.56150684
102VRK10.51815265
103MST1R0.51157053
104BUB10.50892508
105PRKD20.50302065
106ABL10.50004216
107MAP2K20.49902069
108MAPK70.49665063
109TIE10.49516773
110ILK0.48965488
111SIK30.48438462
112HIPK20.48119637
113RPS6KA20.48002974
114NLK0.47647058
115PAK10.46805370
116TLK10.46133835
117EPHB10.46066514
118RPS6KB20.45515749
119RAF10.45432281
120MARK30.45343717
121PDK10.44517912
122WEE10.44227333
123MAP3K80.44104409
124TAOK30.43641527
125CDK40.42929151
126MYLK0.42615154
127MAP2K60.42594206
128PIK3CG0.42144307
129ARAF0.42078042
130BMPR20.41846675
131MAPK120.41506892
132MAP3K50.40466268
133RIPK10.39930238
134ATR0.39929501
135BRAF0.39808979
136PDGFRA0.39535801
137MAPK40.39501577
138ITK0.39415469

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.80730788
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72821045
3Ribosome_Homo sapiens_hsa030102.50677260
4Graft-versus-host disease_Homo sapiens_hsa053322.35422455
5Leishmaniasis_Homo sapiens_hsa051402.34922005
6Allograft rejection_Homo sapiens_hsa053302.34910718
7Base excision repair_Homo sapiens_hsa034102.29421555
8Primary immunodeficiency_Homo sapiens_hsa053402.25939803
9Mismatch repair_Homo sapiens_hsa034302.21199374
10Legionellosis_Homo sapiens_hsa051342.11743524
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.09462349
12Proteasome_Homo sapiens_hsa030502.06982603
13Measles_Homo sapiens_hsa051622.02880082
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01441712
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82124458
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.80810755
17Antigen processing and presentation_Homo sapiens_hsa046121.76752299
18Staphylococcus aureus infection_Homo sapiens_hsa051501.70634224
19Herpes simplex infection_Homo sapiens_hsa051681.70584021
20Pertussis_Homo sapiens_hsa051331.51517757
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50288032
22Viral myocarditis_Homo sapiens_hsa054161.49158452
23Shigellosis_Homo sapiens_hsa051311.46710610
24Malaria_Homo sapiens_hsa051441.45901211
25Fatty acid biosynthesis_Homo sapiens_hsa000611.43720936
26Asthma_Homo sapiens_hsa053101.32607529
27Osteoclast differentiation_Homo sapiens_hsa043801.31766022
28Apoptosis_Homo sapiens_hsa042101.31187285
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30951426
30Homologous recombination_Homo sapiens_hsa034401.28232179
31Autoimmune thyroid disease_Homo sapiens_hsa053201.27300549
32p53 signaling pathway_Homo sapiens_hsa041151.27093236
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.26820576
34Influenza A_Homo sapiens_hsa051641.26745595
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24473624
36Hematopoietic cell lineage_Homo sapiens_hsa046401.24027556
37Nucleotide excision repair_Homo sapiens_hsa034201.20930852
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.19655930
39Tuberculosis_Homo sapiens_hsa051521.19409693
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17974204
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15918076
42Toxoplasmosis_Homo sapiens_hsa051451.15745762
43Other glycan degradation_Homo sapiens_hsa005111.14296228
44TNF signaling pathway_Homo sapiens_hsa046681.13131017
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10968857
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10653826
47Lysosome_Homo sapiens_hsa041421.10086574
48Sulfur metabolism_Homo sapiens_hsa009201.09936150
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08863053
50Salmonella infection_Homo sapiens_hsa051321.07970777
51Sulfur relay system_Homo sapiens_hsa041221.06714123
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04910592
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99050433
54Fructose and mannose metabolism_Homo sapiens_hsa000510.98901050
55Pentose phosphate pathway_Homo sapiens_hsa000300.95713213
56Amoebiasis_Homo sapiens_hsa051460.94417376
57B cell receptor signaling pathway_Homo sapiens_hsa046620.92509555
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91721426
59Hepatitis B_Homo sapiens_hsa051610.91222875
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90539657
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84693313
62Pyrimidine metabolism_Homo sapiens_hsa002400.84641537
63Endocytosis_Homo sapiens_hsa041440.81123065
64Acute myeloid leukemia_Homo sapiens_hsa052210.81066814
65Folate biosynthesis_Homo sapiens_hsa007900.80400564
66Caffeine metabolism_Homo sapiens_hsa002320.79685803
67Type I diabetes mellitus_Homo sapiens_hsa049400.78559138
68Rheumatoid arthritis_Homo sapiens_hsa053230.74668384
69Fatty acid elongation_Homo sapiens_hsa000620.74546725
70Phagosome_Homo sapiens_hsa041450.72625715
71Platelet activation_Homo sapiens_hsa046110.71661224
72Chemokine signaling pathway_Homo sapiens_hsa040620.69404425
73Vibrio cholerae infection_Homo sapiens_hsa051100.68622385
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66311001
75Spliceosome_Homo sapiens_hsa030400.65528954
76African trypanosomiasis_Homo sapiens_hsa051430.63868444
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63775371
78Small cell lung cancer_Homo sapiens_hsa052220.63583261
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63305840
80Pancreatic cancer_Homo sapiens_hsa052120.62819024
81T cell receptor signaling pathway_Homo sapiens_hsa046600.61700385
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60759302
83Epstein-Barr virus infection_Homo sapiens_hsa051690.60474330
84Glutathione metabolism_Homo sapiens_hsa004800.59957801
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59351091
86Hepatitis C_Homo sapiens_hsa051600.58813842
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58453600
88Viral carcinogenesis_Homo sapiens_hsa052030.56930501
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.56076724
90One carbon pool by folate_Homo sapiens_hsa006700.55751138
91VEGF signaling pathway_Homo sapiens_hsa043700.55704666
92Collecting duct acid secretion_Homo sapiens_hsa049660.55370510
93Galactose metabolism_Homo sapiens_hsa000520.54708523
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54132664
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53278100
96Prion diseases_Homo sapiens_hsa050200.50257704
97Arachidonic acid metabolism_Homo sapiens_hsa005900.46997244
98Systemic lupus erythematosus_Homo sapiens_hsa053220.45650947
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45121758
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44896995
101Chronic myeloid leukemia_Homo sapiens_hsa052200.44074615
102PPAR signaling pathway_Homo sapiens_hsa033200.43761376
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.42826175
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41284336
105Fanconi anemia pathway_Homo sapiens_hsa034600.38587726
106N-Glycan biosynthesis_Homo sapiens_hsa005100.38559761
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38322934
108Renin-angiotensin system_Homo sapiens_hsa046140.37997579
109Cell cycle_Homo sapiens_hsa041100.37965741
110Notch signaling pathway_Homo sapiens_hsa043300.37200044
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36763706
112Protein export_Homo sapiens_hsa030600.36510647
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.35152383
114Thyroid cancer_Homo sapiens_hsa052160.34758350
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.34085072
116* HTLV-I infection_Homo sapiens_hsa051660.34024915
117RNA polymerase_Homo sapiens_hsa030200.33875934
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33750957
119Non-small cell lung cancer_Homo sapiens_hsa052230.33314233
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33016166
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32304659
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32285782
123Focal adhesion_Homo sapiens_hsa045100.31644528
124Sphingolipid metabolism_Homo sapiens_hsa006000.31603533
125Peroxisome_Homo sapiens_hsa041460.31314241
126Bladder cancer_Homo sapiens_hsa052190.31185968
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.29991349

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