TSPOAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.01033971
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.94891385
3synaptic vesicle exocytosis (GO:0016079)5.93691970
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78478980
5glutamate secretion (GO:0014047)5.55062603
6regulation of synaptic vesicle exocytosis (GO:2000300)5.51537871
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50519981
8locomotory exploration behavior (GO:0035641)4.87018152
9regulation of ARF protein signal transduction (GO:0032012)4.84414689
10regulation of synaptic vesicle transport (GO:1902803)4.62145563
11neurotransmitter secretion (GO:0007269)4.58700568
12L-amino acid import (GO:0043092)4.47969648
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.41004103
14regulation of neuronal synaptic plasticity (GO:0048168)4.40996781
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.32405568
16vocalization behavior (GO:0071625)4.31538333
17exploration behavior (GO:0035640)4.26289247
18cellular potassium ion homeostasis (GO:0030007)4.20760580
19cerebellar granule cell differentiation (GO:0021707)4.19131415
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.06707869
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.03407270
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01541312
23sodium ion export (GO:0071436)3.99058385
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93762506
25positive regulation of synapse maturation (GO:0090129)3.87311417
26regulation of glutamate receptor signaling pathway (GO:1900449)3.86845111
27dendritic spine morphogenesis (GO:0060997)3.82197670
28cerebellar Purkinje cell differentiation (GO:0021702)3.77196917
29amino acid import (GO:0043090)3.63009788
30positive regulation of membrane potential (GO:0045838)3.60761880
31synaptic transmission, glutamatergic (GO:0035249)3.60597988
32G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.56886771
33neuronal ion channel clustering (GO:0045161)3.56371696
34neurotransmitter transport (GO:0006836)3.53006423
35protein localization to synapse (GO:0035418)3.48227690
36regulation of synaptic plasticity (GO:0048167)3.44414652
37negative regulation of erythrocyte differentiation (GO:0045647)3.40887981
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.40365122
39regulation of neurotransmitter levels (GO:0001505)3.40295260
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38186432
41neuromuscular process controlling balance (GO:0050885)3.36883173
42synaptic vesicle endocytosis (GO:0048488)3.34705297
43postsynaptic membrane organization (GO:0001941)3.33621339
44neuronal action potential propagation (GO:0019227)3.32708684
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32558371
46regulation of voltage-gated calcium channel activity (GO:1901385)3.30410069
47regulation of neurotransmitter secretion (GO:0046928)3.30145140
48regulation of synapse maturation (GO:0090128)3.27800359
49positive regulation of Rap GTPase activity (GO:0032854)3.25975227
50glutamate receptor signaling pathway (GO:0007215)3.23507891
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19883690
52positive regulation of dendritic spine development (GO:0060999)3.18707878
53regulation of vesicle fusion (GO:0031338)3.17968008
54regulation of synapse structural plasticity (GO:0051823)3.16433365
55neuron-neuron synaptic transmission (GO:0007270)3.11077038
56potassium ion import (GO:0010107)3.10797384
57neurotransmitter-gated ion channel clustering (GO:0072578)3.06090843
58regulation of postsynaptic membrane potential (GO:0060078)3.05827544
59potassium ion homeostasis (GO:0055075)3.03998530
60long-term memory (GO:0007616)3.03929925
61axon ensheathment in central nervous system (GO:0032291)3.03131864
62central nervous system myelination (GO:0022010)3.03131864
63gamma-aminobutyric acid transport (GO:0015812)3.02055558
64regulation of Rap GTPase activity (GO:0032317)2.97533195
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94914935
66membrane depolarization during action potential (GO:0086010)2.94724906
67regulation of neurotransmitter transport (GO:0051588)2.93704683
68cell differentiation in hindbrain (GO:0021533)2.91723720
69mechanosensory behavior (GO:0007638)2.89401291
70negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88093344
71regulation of ARF GTPase activity (GO:0032312)2.84445890
72neuron cell-cell adhesion (GO:0007158)2.84168516
73gamma-aminobutyric acid signaling pathway (GO:0007214)2.82667327
74activation of protein kinase A activity (GO:0034199)2.81803007
75regulation of exocytosis (GO:0017157)2.80809458
76dendritic spine organization (GO:0097061)2.80380635
77layer formation in cerebral cortex (GO:0021819)2.80324486
78auditory behavior (GO:0031223)2.80301958
79membrane depolarization (GO:0051899)2.79994952
80positive regulation of neurotransmitter secretion (GO:0001956)2.77967009
81mannose metabolic process (GO:0006013)2.76213893
82negative regulation of dendrite morphogenesis (GO:0050774)2.75444747
83phosphorelay signal transduction system (GO:0000160)2.75327123
84regulation of female receptivity (GO:0045924)2.74618608
85long-term synaptic potentiation (GO:0060291)2.73994485
86regulation of synaptic transmission (GO:0050804)2.73097678
87peptidyl-tyrosine autophosphorylation (GO:0038083)2.70537189
88positive regulation of neurotransmitter transport (GO:0051590)2.69429239
89visual learning (GO:0008542)2.65088554
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.59550702
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.58777902
92transmission of nerve impulse (GO:0019226)2.58677073
93visual behavior (GO:0007632)2.57976876
94regulation of dendritic spine morphogenesis (GO:0061001)2.57538482
95signal complex assembly (GO:0007172)2.56683630
96cell communication by electrical coupling (GO:0010644)2.55756615
97positive thymic T cell selection (GO:0045059)2.54136350
98regulation of dendritic spine development (GO:0060998)2.53652860
99dopamine receptor signaling pathway (GO:0007212)2.53086715
100learning (GO:0007612)2.52909363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.30353470
2DROSHA_22980978_ChIP-Seq_HELA_Human3.88127605
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.24358387
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.87419129
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.74143316
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72019414
7REST_21632747_ChIP-Seq_MESCs_Mouse2.56989953
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.56892466
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45898891
10VDR_21846776_ChIP-Seq_THP-1_Human2.44437807
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27117740
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19357259
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17219249
14KDM2B_26808549_Chip-Seq_DND41_Human2.14479696
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11590864
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.11138954
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08654130
18KDM2B_26808549_Chip-Seq_K562_Human2.01910873
19LXR_22292898_ChIP-Seq_THP-1_Human2.01335606
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99267594
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.97830805
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97772704
23GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.97551697
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96380729
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.93235351
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86232836
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85103877
28TCF7_22412390_ChIP-Seq_EML_Mouse1.84307864
29VDR_24763502_ChIP-Seq_THP-1_Human1.81936619
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.81839285
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80170986
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78314800
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76363787
34SCL_19346495_ChIP-Seq_HPC-7_Human1.71858888
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67748601
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67748601
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65691674
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64573322
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61779991
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.61679743
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.59976448
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58377004
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56726919
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56015403
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53194908
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52947230
47MYC_22102868_ChIP-Seq_BL_Human1.49369507
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48320247
49P68_20966046_ChIP-Seq_HELA_Human1.46557340
50SMC4_20622854_ChIP-Seq_HELA_Human1.46219661
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44822195
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.43679229
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42774589
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42406704
55CTCF_27219007_Chip-Seq_Bcells_Human1.38486883
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.38387553
57OCT4_19829295_ChIP-Seq_ESCs_Human1.32067686
58CREB1_26743006_Chip-Seq_LNCaP_Human1.28981504
59AR_21572438_ChIP-Seq_LNCaP_Human1.23120937
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19123294
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18508042
62RUNX_20019798_ChIP-Seq_JUKART_Human1.18168851
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16274541
64UTX_26944678_Chip-Seq_JUKART_Human1.14764368
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14622783
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.14087649
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.13433073
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11255278
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10179471
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09897892
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09219419
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.09009239
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08728395
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08518304
75SPI1_23127762_ChIP-Seq_K562_Human1.06281160
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05402447
77KLF4_19829295_ChIP-Seq_ESCs_Human1.04997728
78MAF_26560356_Chip-Seq_TH1_Human1.03829071
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02101596
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00053903
81ESR2_21235772_ChIP-Seq_MCF-7_Human0.99614760
82MAF_26560356_Chip-Seq_TH2_Human0.99592135
83RING1B_27294783_Chip-Seq_ESCs_Mouse0.99459597
84RUNX1_22412390_ChIP-Seq_EML_Mouse0.98547576
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98519835
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97591961
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95318404
88TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94678152
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94565202
90BCOR_27268052_Chip-Seq_Bcells_Human0.94547301
91AR_19668381_ChIP-Seq_PC3_Human0.93017932
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92887388
93GATA1_19941826_ChIP-Seq_K562_Human0.92847250
94MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91487485
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90955865
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90022407
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86452246
98TET1_21451524_ChIP-Seq_MESCs_Mouse0.85209014
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85133189
100BCL6_27268052_Chip-Seq_Bcells_Human0.84018656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31492700
2MP0003880_abnormal_central_pattern4.45516587
3MP0003635_abnormal_synaptic_transmissio3.79762538
4MP0005423_abnormal_somatic_nervous3.69147900
5MP0002064_seizures3.31039763
6MP0004270_analgesia3.19841991
7MP0002063_abnormal_learning/memory/cond3.05377166
8MP0009745_abnormal_behavioral_response2.98061499
9MP0001486_abnormal_startle_reflex2.81478427
10MP0002572_abnormal_emotion/affect_behav2.50568324
11MP0003172_abnormal_lysosome_physiology2.43328466
12MP0002272_abnormal_nervous_system2.42628937
13MP0009046_muscle_twitch2.41108516
14MP0008569_lethality_at_weaning2.38902116
15MP0001968_abnormal_touch/_nociception2.38677452
16MP0001501_abnormal_sleep_pattern2.32056678
17MP0002734_abnormal_mechanical_nocicepti2.24985170
18MP0003787_abnormal_imprinting2.24796877
19MP0002735_abnormal_chemical_nociception2.22370461
20MP0003690_abnormal_glial_cell2.18145839
21MP0003329_amyloid_beta_deposits1.91774126
22MP0001970_abnormal_pain_threshold1.87740009
23MP0002822_catalepsy1.83469164
24MP0009278_abnormal_bone_marrow1.76525342
25MP0003879_abnormal_hair_cell1.71309555
26MP0002733_abnormal_thermal_nociception1.71174842
27MP0001986_abnormal_taste_sensitivity1.65029412
28MP0004742_abnormal_vestibular_system1.55082936
29MP0003183_abnormal_peptide_metabolism1.51418147
30MP0001502_abnormal_circadian_rhythm1.50493188
31MP0004811_abnormal_neuron_physiology1.47563823
32MP0002067_abnormal_sensory_capabilities1.44118871
33MP0004885_abnormal_endolymph1.37828644
34MP0003303_peritoneal_inflammation1.35121078
35MP0000920_abnormal_myelination1.35109086
36MP0003633_abnormal_nervous_system1.34230264
37MP0002396_abnormal_hematopoietic_system1.34005405
38MP0002557_abnormal_social/conspecific_i1.33417962
39MP0002066_abnormal_motor_capabilities/c1.30328963
40MP0001440_abnormal_grooming_behavior1.25504321
41MP0009780_abnormal_chondrocyte_physiolo1.25385253
42MP0005646_abnormal_pituitary_gland1.23584339
43MP0002736_abnormal_nociception_after1.22351779
44MP0004130_abnormal_muscle_cell1.21320578
45MP0002882_abnormal_neuron_morphology1.18952228
46MP0003631_nervous_system_phenotype1.16989050
47MP0000778_abnormal_nervous_system1.16553294
48MP0004924_abnormal_behavior1.15631844
49MP0005386_behavior/neurological_phenoty1.15631844
50MP0002653_abnormal_ependyma_morphology1.14151707
51MP0001485_abnormal_pinna_reflex1.07845954
52MP0000604_amyloidosis1.07444192
53MP0000569_abnormal_digit_pigmentation1.06571349
54MP0003436_decreased_susceptibility_to1.05938471
55MP0003075_altered_response_to1.02863351
56MP0001177_atelectasis1.02133159
57MP0001984_abnormal_olfaction1.01335742
58MP0000955_abnormal_spinal_cord1.00705187
59MP0003763_abnormal_thymus_physiology1.00549579
60MP0006276_abnormal_autonomic_nervous0.98855969
61MP0001963_abnormal_hearing_physiology0.98285366
62MP0002229_neurodegeneration0.97601164
63MP0003634_abnormal_glial_cell0.97360037
64MP0008874_decreased_physiological_sensi0.96966859
65MP0005535_abnormal_body_temperature0.96482898
66MP0005409_darkened_coat_color0.96082641
67MP0002152_abnormal_brain_morphology0.92061652
68MP0005397_hematopoietic_system_phenotyp0.88381042
69MP0001545_abnormal_hematopoietic_system0.88381042
70MP0003632_abnormal_nervous_system0.82629522
71MP0005645_abnormal_hypothalamus_physiol0.80848049
72MP0001835_abnormal_antigen_presentation0.79497148
73MP0004043_abnormal_pH_regulation0.75515234
74MP0001905_abnormal_dopamine_level0.75237517
75MP0002419_abnormal_innate_immunity0.75104527
76MP0001800_abnormal_humoral_immune0.73231077
77MP0008877_abnormal_DNA_methylation0.71627051
78MP0002420_abnormal_adaptive_immunity0.71064041
79MP0001765_abnormal_ion_homeostasis0.69516015
80MP0003122_maternal_imprinting0.69285752
81MP0005025_abnormal_response_to0.68955754
82MP0002184_abnormal_innervation0.68413552
83MP0001819_abnormal_immune_cell0.68375232
84MP0000015_abnormal_ear_pigmentation0.65906206
85MP0000566_synostosis0.64764553
86MP0005166_decreased_susceptibility_to0.63897772
87MP0000681_abnormal_thyroid_gland0.63829728
88MP0003045_fibrosis0.63663494
89MP0005000_abnormal_immune_tolerance0.62926257
90MP0002398_abnormal_bone_marrow0.61480284
91MP0002083_premature_death0.59386354
92MP0002069_abnormal_eating/drinking_beha0.59281261
93MP0004381_abnormal_hair_follicle0.58648032
94MP0002873_normal_phenotype0.57271660
95MP0003283_abnormal_digestive_organ0.56850216
96MP0000703_abnormal_thymus_morphology0.56308216
97MP0002169_no_abnormal_phenotype0.55847491
98MP0000716_abnormal_immune_system0.54828936
99MP0010769_abnormal_survival0.54079093
100MP0002638_abnormal_pupillary_reflex0.53219713

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.07110104
2Focal motor seizures (HP:0011153)5.48252540
3Papilledema (HP:0001085)4.83805318
4Obstructive sleep apnea (HP:0002870)4.72831148
5Focal seizures (HP:0007359)4.68210332
6Febrile seizures (HP:0002373)4.59984628
7Diplopia (HP:0000651)4.45794803
8Abnormality of binocular vision (HP:0011514)4.45794803
9Supranuclear gaze palsy (HP:0000605)4.36203130
10Epileptic encephalopathy (HP:0200134)4.32365912
11Ankle clonus (HP:0011448)4.23831815
12Hemiplegia (HP:0002301)4.01981910
13Visual hallucinations (HP:0002367)3.74230057
14Annular pancreas (HP:0001734)3.59036036
15Action tremor (HP:0002345)3.58179832
16Progressive cerebellar ataxia (HP:0002073)3.50877539
17Atonic seizures (HP:0010819)3.27409090
18Postural instability (HP:0002172)3.26684213
19Spastic gait (HP:0002064)3.24416151
20Neurofibrillary tangles (HP:0002185)3.09563197
21Panhypogammaglobulinemia (HP:0003139)2.98508337
22Hyperventilation (HP:0002883)2.96754452
23Urinary bladder sphincter dysfunction (HP:0002839)2.96126689
24Abnormal eating behavior (HP:0100738)2.82762912
25Neuronal loss in central nervous system (HP:0002529)2.81148182
26Truncal ataxia (HP:0002078)2.78410813
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.71925091
28Absent/shortened dynein arms (HP:0200106)2.71925091
29Impaired smooth pursuit (HP:0007772)2.68904995
30Sleep apnea (HP:0010535)2.66157459
31Acute lymphatic leukemia (HP:0006721)2.64716526
32Tetraplegia (HP:0002445)2.64376147
33Torticollis (HP:0000473)2.60737099
34Abnormal respiratory epithelium morphology (HP:0012253)2.58060874
35Abnormal respiratory motile cilium morphology (HP:0005938)2.58060874
36Generalized tonic-clonic seizures (HP:0002069)2.57660750
37Genetic anticipation (HP:0003743)2.56273476
38Absence seizures (HP:0002121)2.53950625
39Depression (HP:0000716)2.51295685
40Dysmetria (HP:0001310)2.49189364
41Agammaglobulinemia (HP:0004432)2.46769357
42Stereotypic behavior (HP:0000733)2.45876273
43Abnormal ciliary motility (HP:0012262)2.38800606
44Cerebral inclusion bodies (HP:0100314)2.36108118
45Peripheral hypomyelination (HP:0007182)2.35777011
46Dysdiadochokinesis (HP:0002075)2.34234532
47Dialeptic seizures (HP:0011146)2.30571450
48Mutism (HP:0002300)2.29852423
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29587794
50Lower limb muscle weakness (HP:0007340)2.25644275
51Abnormality of the fingertips (HP:0001211)2.24208717
52Clonus (HP:0002169)2.22943291
53Intention tremor (HP:0002080)2.22158571
54Abnormality of ocular smooth pursuit (HP:0000617)2.21743615
55Status epilepticus (HP:0002133)2.20878340
56Lower limb asymmetry (HP:0100559)2.20255134
57Impaired vibration sensation in the lower limbs (HP:0002166)2.16291023
58Abnormal respiratory motile cilium physiology (HP:0012261)2.16113050
59Urinary urgency (HP:0000012)2.15091766
60Poor eye contact (HP:0000817)2.14840549
61Dysmetric saccades (HP:0000641)2.14652046
62Slow saccadic eye movements (HP:0000514)2.11964995
63Spinal canal stenosis (HP:0003416)2.11172523
64Pointed chin (HP:0000307)2.11079987
65Bradykinesia (HP:0002067)2.09569443
66Ocular albinism (HP:0001107)2.08176732
67Nasal polyposis (HP:0100582)2.03204998
68Limb dystonia (HP:0002451)2.03143571
69Impaired vibratory sensation (HP:0002495)2.01752007
70Focal dystonia (HP:0004373)1.99234184
71Absent speech (HP:0001344)1.99224647
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98366993
73Scanning speech (HP:0002168)1.96913313
74Hypoplasia of the thymus (HP:0000778)1.93617808
75Gaze-evoked nystagmus (HP:0000640)1.93166115
76Abnormality of saccadic eye movements (HP:0000570)1.92069583
77Apathy (HP:0000741)1.90443535
78Megalencephaly (HP:0001355)1.89935799
79Delusions (HP:0000746)1.87047915
80Abnormal social behavior (HP:0012433)1.84478064
81Impaired social interactions (HP:0000735)1.84478064
82Epileptiform EEG discharges (HP:0011182)1.84239756
83Hemiparesis (HP:0001269)1.83963911
84Rhinitis (HP:0012384)1.83742520
85Iris hypopigmentation (HP:0007730)1.83090640
86Chronic otitis media (HP:0000389)1.81889509
87Craniofacial dystonia (HP:0012179)1.79291353
88Meningitis (HP:0001287)1.76960834
89Bowel incontinence (HP:0002607)1.76639657
90Bronchomalacia (HP:0002780)1.76399279
91Rigidity (HP:0002063)1.75823877
92Broad face (HP:0000283)1.75279944
93B lymphocytopenia (HP:0010976)1.75059338
94Abnormal delayed hypersensitivity skin test (HP:0002963)1.74255171
95Intellectual disability, severe (HP:0010864)1.74123558
96Recurrent fungal infections (HP:0002841)1.73001508
97Polygenic inheritance (HP:0010982)1.72461872
98Abnormality of the lower motor neuron (HP:0002366)1.72120577
99Rapidly progressive (HP:0003678)1.69093780
100Diminished motivation (HP:0000745)1.68501935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.81466691
2DAPK23.28299639
3RIPK43.20553597
4NTRK33.18918281
5PAK62.99101460
6PRPF4B2.84754307
7TNK22.50684344
8CAMKK12.50201021
9MARK12.38655093
10UHMK12.30997269
11NTRK22.11934870
12SIK22.06277924
13PRKD32.04091018
14FES2.01373858
15MARK21.99611697
16MAPK151.74074227
17TRIB31.52018268
18MAP3K131.48822917
19MINK11.44775804
20MAPK121.42612434
21KIT1.41743149
22MAP4K11.41549241
23CDK191.33652449
24PRKCH1.26685251
25RIPK11.26348051
26SGK2231.23913344
27SGK4941.23913344
28CAMK11.23260947
29CDK51.18635457
30MAPK131.17074572
31STK111.14328531
32GRK51.12741902
33CDK121.11409265
34SGK21.09308958
35MAP3K71.08489480
36KSR21.06191962
37PDK11.01408754
38SYK0.99943475
39BTK0.97119292
40SGK30.91876210
41NTRK10.91620693
42DAPK10.91404939
43TYRO30.90851920
44MAP3K40.86713559
45CAMK40.86082724
46DYRK1A0.85562652
47HIPK20.85509799
48RET0.85460878
49MAP2K40.83901040
50MAP2K60.83823094
51ITK0.83128081
52NEK60.82030016
53STK380.80617773
54EEF2K0.80363484
55ICK0.77951087
56SGK10.77814527
57ZAP700.77037976
58BMPR20.75293599
59PDPK10.74166911
60MAPK70.72872607
61JAK10.71864559
62MAP3K110.71395689
63MAP2K30.69900102
64MAP3K60.69172998
65TEC0.68743635
66MAPK100.67920189
67ERN10.66097942
68BRD40.64255538
69JAK20.62566361
70CDC42BPA0.61742234
71TAOK30.60919065
72FYN0.59971985
73HCK0.59026820
74GRK60.58914495
75PKN10.58897936
76ARAF0.58601331
77MAPK80.54815370
78CAMK2B0.54264042
79ALK0.52464409
80RPS6KA30.50558484
81CASK0.50126788
82MAP3K10.49919598
83ERBB20.49873820
84MAPK40.49849808
85CAMKK20.49801244
86FGFR20.47625917
87PRKCG0.47588580
88MAP3K90.45319942
89CDK150.43078305
90CAMK2A0.43002944
91CDK11A0.41365470
92PRKCQ0.40395618
93BLK0.40060019
94RPS6KA20.39452135
95PRKD20.38215957
96PINK10.37003545
97LCK0.36932674
98SMG10.36887410
99CDK180.36404861
100PRKCZ0.35280986

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94855614
2Synaptic vesicle cycle_Homo sapiens_hsa047212.70771462
3Long-term potentiation_Homo sapiens_hsa047202.49399569
4Circadian entrainment_Homo sapiens_hsa047132.29930242
5Morphine addiction_Homo sapiens_hsa050322.20900547
6Glutamatergic synapse_Homo sapiens_hsa047242.19537138
7Amphetamine addiction_Homo sapiens_hsa050312.18465584
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13942786
9GABAergic synapse_Homo sapiens_hsa047272.04097882
10Insulin secretion_Homo sapiens_hsa049112.01324676
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87803743
12Gastric acid secretion_Homo sapiens_hsa049711.87325943
13Cholinergic synapse_Homo sapiens_hsa047251.82070310
14Dopaminergic synapse_Homo sapiens_hsa047281.72574735
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.71485313
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70023470
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66854771
18Cocaine addiction_Homo sapiens_hsa050301.64811492
19Salivary secretion_Homo sapiens_hsa049701.63343592
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.61910883
21Oxytocin signaling pathway_Homo sapiens_hsa049211.60322179
22GnRH signaling pathway_Homo sapiens_hsa049121.54586865
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46502307
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.44330232
25Calcium signaling pathway_Homo sapiens_hsa040201.43218858
26cAMP signaling pathway_Homo sapiens_hsa040241.38177278
27Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.33358043
28Renin secretion_Homo sapiens_hsa049241.29408559
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28290191
30Glioma_Homo sapiens_hsa052141.27491625
31Estrogen signaling pathway_Homo sapiens_hsa049151.25819914
32VEGF signaling pathway_Homo sapiens_hsa043701.25166924
33Choline metabolism in cancer_Homo sapiens_hsa052311.22406878
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21014122
35Taste transduction_Homo sapiens_hsa047421.18425883
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.18079949
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17898005
38ErbB signaling pathway_Homo sapiens_hsa040121.16181253
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16057800
40B cell receptor signaling pathway_Homo sapiens_hsa046621.15427371
41Long-term depression_Homo sapiens_hsa047301.07306157
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06547557
43Inositol phosphate metabolism_Homo sapiens_hsa005621.05667109
44Type II diabetes mellitus_Homo sapiens_hsa049301.02494093
45Acute myeloid leukemia_Homo sapiens_hsa052210.99923510
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99823112
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97708464
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96564375
49Non-small cell lung cancer_Homo sapiens_hsa052230.94627240
50Olfactory transduction_Homo sapiens_hsa047400.93685451
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91182949
52Serotonergic synapse_Homo sapiens_hsa047260.91002944
53Pancreatic secretion_Homo sapiens_hsa049720.89227587
54Melanogenesis_Homo sapiens_hsa049160.88510461
55Dorso-ventral axis formation_Homo sapiens_hsa043200.87536068
56MAPK signaling pathway_Homo sapiens_hsa040100.87437968
57T cell receptor signaling pathway_Homo sapiens_hsa046600.85042880
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.82107106
59mTOR signaling pathway_Homo sapiens_hsa041500.81088549
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80239570
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.79887413
62Rap1 signaling pathway_Homo sapiens_hsa040150.75339865
63Osteoclast differentiation_Homo sapiens_hsa043800.73851445
64Gap junction_Homo sapiens_hsa045400.71707232
65Ras signaling pathway_Homo sapiens_hsa040140.71572719
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71154485
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.69908906
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67882922
69Notch signaling pathway_Homo sapiens_hsa043300.66778314
70Alcoholism_Homo sapiens_hsa050340.65834407
71Other glycan degradation_Homo sapiens_hsa005110.65354977
72Chronic myeloid leukemia_Homo sapiens_hsa052200.65183480
73Platelet activation_Homo sapiens_hsa046110.64697437
74Chemokine signaling pathway_Homo sapiens_hsa040620.62872447
75Thyroid hormone synthesis_Homo sapiens_hsa049180.62614758
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60326256
77Prolactin signaling pathway_Homo sapiens_hsa049170.59808906
78Renal cell carcinoma_Homo sapiens_hsa052110.59756214
79Endocytosis_Homo sapiens_hsa041440.58737503
80Tuberculosis_Homo sapiens_hsa051520.56234375
81Primary immunodeficiency_Homo sapiens_hsa053400.55217743
82Endometrial cancer_Homo sapiens_hsa052130.54537348
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53355520
84Leishmaniasis_Homo sapiens_hsa051400.49037584
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48730854
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47568885
87Axon guidance_Homo sapiens_hsa043600.47556447
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.46941393
89Phototransduction_Homo sapiens_hsa047440.46464102
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45829674
91Collecting duct acid secretion_Homo sapiens_hsa049660.45619501
92Bile secretion_Homo sapiens_hsa049760.45592638
93Colorectal cancer_Homo sapiens_hsa052100.45288098
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44077603
95Pancreatic cancer_Homo sapiens_hsa052120.43476566
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38725420
97Insulin signaling pathway_Homo sapiens_hsa049100.38297030
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37652108
99Glucagon signaling pathway_Homo sapiens_hsa049220.37537471
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35654848

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