ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* mesoderm development (GO:0007498)	8.09631985
2	* mesenchyme development (GO:0060485)	7.49049016
3	* gonadal mesoderm development (GO:0007506)	60.2454466
4	sex differentiation (GO:0007548)	5.96581238
5	N-acetylneuraminate metabolic process (GO:0006054)	5.60202122
6	* nucleosome assembly (GO:0006334)	4.72169076
7	* protein-DNA complex assembly (GO:0065004)	4.09131131
8	* nucleosome organization (GO:0034728)	3.74087672
9	piRNA metabolic process (GO:0034587)	3.74010217
10	* protein-DNA complex subunit organization (GO:0071824)	3.34096867
11	regulation of activation of Janus kinase activity (GO:0010533)	3.07148999
12	interleukin-6-mediated signaling pathway (GO:0070102)	3.00811398
13	ribosomal small subunit biogenesis (GO:0042274)	2.83839713
14	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.69909856
15	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.69909856
16	regulation of isotype switching to IgG isotypes (GO:0048302)	2.63367171
17	protein K63-linked deubiquitination (GO:0070536)	2.48993004
18	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.47775422
19	DNA methylation involved in gamete generation (GO:0043046)	2.45617319
20	protein K48-linked deubiquitination (GO:0071108)	2.40307114
21	viral transcription (GO:0019083)	2.31748028
22	apoptotic cell clearance (GO:0043277)	2.29743489
23	ribosomal small subunit assembly (GO:0000028)	2.29062444
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.28740827
25	translational termination (GO:0006415)	2.27109069
26	cotranslational protein targeting to membrane (GO:0006613)	2.24044722
27	protein localization to endoplasmic reticulum (GO:0070972)	2.23424671
28	protein targeting to ER (GO:0045047)	2.21634484
29	sialylation (GO:0097503)	2.12589190
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.12282561
31	COPI coating of Golgi vesicle (GO:0048205)	2.11161487
32	Golgi transport vesicle coating (GO:0048200)	2.11161487
33	male meiosis (GO:0007140)	2.11075866
34	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.09559954
35	organ or tissue specific immune response (GO:0002251)	2.06541164
36	translational elongation (GO:0006414)	2.05819077
37	positive regulation of viral genome replication (GO:0045070)	2.04113781
38	sodium ion homeostasis (GO:0055078)	2.00813335
39	positive regulation of translational initiation (GO:0045948)	1.94184816
40	cellular response to interleukin-6 (GO:0071354)	1.93852434
41	meiotic chromosome segregation (GO:0045132)	1.92911598
42	* spermatogenesis (GO:0007283)	1.87999310
43	* male gamete generation (GO:0048232)	1.87451878
44	viral life cycle (GO:0019058)	1.85782968
45	regulation of penile erection (GO:0060405)	1.84263047
46	positive regulation of alpha-beta T cell proliferation (GO:0046641)	1.84077285
47	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	1.81410711
48	cellular sodium ion homeostasis (GO:0006883)	1.81276897
49	actin nucleation (GO:0045010)	1.78768218
50	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	1.78312759
51	translational initiation (GO:0006413)	1.73524850
52	cellular protein complex disassembly (GO:0043624)	1.70879577
53	protein targeting to membrane (GO:0006612)	1.70386502
54	* gamete generation (GO:0007276)	1.69382251
55	synaptonemal complex assembly (GO:0007130)	1.65232744
56	formation of translation preinitiation complex (GO:0001731)	1.62389857
57	ER overload response (GO:0006983)	1.61417430
58	* reproductive structure development (GO:0048608)	1.60655114
59	regulation of translational fidelity (GO:0006450)	1.60381132
60	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	1.59891195
61	ganglioside metabolic process (GO:0001573)	1.59765771
62	positive regulation of mitochondrial membrane permeability (GO:0035794)	1.58288178
63	negative regulation of Notch signaling pathway (GO:0045746)	1.57946919
64	proline biosynthetic process (GO:0006561)	1.56218521
65	gene silencing by RNA (GO:0031047)	1.55640582
66	translation (GO:0006412)	1.55511785
67	amyloid precursor protein catabolic process (GO:0042987)	1.55366790
68	positive regulation of isotype switching (GO:0045830)	1.54339795
69	response to interleukin-6 (GO:0070741)	1.53105007
70	neutrophil mediated immunity (GO:0002446)	1.53098315
71	male meiosis I (GO:0007141)	1.51209404
72	complement activation, classical pathway (GO:0006958)	1.50374985
73	synaptonemal complex organization (GO:0070193)	1.49497403
74	positive regulation of urine volume (GO:0035810)	1.49123003
75	viral protein processing (GO:0019082)	1.48935493
76	meiosis I (GO:0007127)	1.48846139
77	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	1.48410036
78	protoporphyrinogen IX metabolic process (GO:0046501)	1.48122750
79	pH reduction (GO:0045851)	1.46894348
80	signal peptide processing (GO:0006465)	1.46893267
81	negative thymic T cell selection (GO:0045060)	1.46253249
82	ribonucleoprotein complex biogenesis (GO:0022613)	1.45636932
83	autophagic vacuole fusion (GO:0000046)	1.45562349
84	regulation of cytokine production involved in inflammatory response (GO:1900015)	1.44036398
85	regulation of urine volume (GO:0035809)	1.42736996
86	protein N-linked glycosylation via asparagine (GO:0018279)	1.42392061
87	amino sugar metabolic process (GO:0006040)	1.41565826
88	peptidyl-asparagine modification (GO:0018196)	1.40606073
89	regulation of mitochondrial membrane permeability (GO:0046902)	1.40170046
90	amyloid precursor protein metabolic process (GO:0042982)	1.39107352
91	negative regulation of translational initiation (GO:0045947)	1.39101140
92	regulation of translation in response to stress (GO:0043555)	1.38955818
93	mitotic metaphase plate congression (GO:0007080)	1.38564679
94	mitotic chromosome condensation (GO:0007076)	1.37495470
95	protein complex disassembly (GO:0043241)	1.37406357
96	preassembly of GPI anchor in ER membrane (GO:0016254)	1.36631333
97	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	1.35400345
98	one-carbon compound transport (GO:0019755)	1.34482355
99	regulation of inflammatory response to antigenic stimulus (GO:0002861)	1.34365014
100	protein insertion into membrane (GO:0051205)	1.34059349

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.47896108
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.85923398
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.77241897
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.20198117
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.55022301
6	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.50295132
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.46556393
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.42732363
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.19779622
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.09082898
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.05552983
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.86813398
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.64461031
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.60866242
15	TFEB_21752829_ChIP-Seq_HELA_Human	2.47352337
16	DCP1A_22483619_ChIP-Seq_HELA_Human	2.37491822
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33609808
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.33474764
19	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.30545899
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.16527313
21	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	2.15906173
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15052303
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.10883236
24	TTF2_22483619_ChIP-Seq_HELA_Human	2.09192911
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.08111819
26	IGF1R_20145208_ChIP-Seq_DFB_Human	2.06130607
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.03732608
28	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03392246
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.03164053
30	GABP_19822575_ChIP-Seq_HepG2_Human	2.02761370
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.01584171
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93821120
33	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.82235261
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.80717125
35	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.74764553
36	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.71751966
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68084907
38	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.65755316
39	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.65351786
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.64563757
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.63907523
42	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.63659270
43	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.63004002
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.57926435
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54006483
46	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.50326577
47	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.49010314
48	EZH2_22144423_ChIP-Seq_EOC_Human	1.48319789
49	MYC_22102868_ChIP-Seq_BL_Human	1.44900828
50	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.44510055
51	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42703685
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.40812363
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39933251
54	MYB_26560356_Chip-Seq_TH2_Human	1.39892914
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33833855
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.30147641
57	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.28371478
58	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.28347617
59	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.27730511
60	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	1.24918863
61	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.24096252
62	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23259152
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22858991
64	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.22253614
65	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.22141980
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.19638977
67	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.19388676
68	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.18560368
69	STAT1_20625510_ChIP-Seq_HELA_Human	1.16965192
70	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.12064640
71	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.11466999
72	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09804049
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.08338272
74	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.08092914
75	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05989634
76	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.05368193
77	MYC_18940864_ChIP-ChIP_HL60_Human	1.04958860
78	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.00885610
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.00802243
80	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.97940313
81	SPI1_23547873_ChIP-Seq_NB4_Human	0.93620276
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90091023
83	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.89670652
84	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.86839887
85	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80305987
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79812826
87	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.79806135
88	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.79794525
89	P300_27268052_Chip-Seq_Bcells_Human	0.79704681
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.78586127
91	GATA3_26560356_Chip-Seq_TH2_Human	0.76509376
92	MYB_26560356_Chip-Seq_TH1_Human	0.75951310
93	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.74806712
94	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.73990952
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.73515186
96	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.71879522
97	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.71795523
98	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.71253497
99	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.68922264
100	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.67833710

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	7.64298463
2	MP0003136_yellow_coat_color	6.22901655
3	MP0005058_abnormal_lysosome_morphology	3.86263603
4	MP0005171_absent_coat_pigmentation	3.65897429
5	MP0003183_abnormal_peptide_metabolism	3.18545965
6	MP0009333_abnormal_splenocyte_physiolog	3.10634717
7	MP0003693_abnormal_embryo_hatching	2.67382565
8	MP0008995_early_reproductive_senescence	2.63051435
9	MP0008877_abnormal_DNA_methylation	2.16211821
10	MP0005174_abnormal_tail_pigmentation	2.13541341
11	MP0005408_hypopigmentation	2.10942135
12	MP0005671_abnormal_response_to	1.92538840
13	MP0000372_irregular_coat_pigmentation	1.91398330
14	MP0008057_abnormal_DNA_replication	1.88445329
15	MP0004957_abnormal_blastocyst_morpholog	1.86965568
16	MP0009840_abnormal_foam_cell	1.85137834
17	MP0003806_abnormal_nucleotide_metabolis	1.84505024
18	MP0004043_abnormal_pH_regulation	1.81255047
19	MP0003172_abnormal_lysosome_physiology	1.71823054
20	MP0004147_increased_porphyrin_level	1.66677396
21	MP0005075_abnormal_melanosome_morpholog	1.65537620
22	MP0003763_abnormal_thymus_physiology	1.65370185
23	MP0002095_abnormal_skin_pigmentation	1.61415612
24	MP0002090_abnormal_vision	1.61130984
25	MP0002168_other_aberrant_phenotype	1.54265465
26	MP0001348_abnormal_lacrimal_gland	1.54116318
27	MP0003077_abnormal_cell_cycle	1.51969013
28	MP0003786_premature_aging	1.50879207
29	MP0001929_abnormal_gametogenesis	1.46196459
30	MP0002210_abnormal_sex_determination	1.44695586
31	MP0002138_abnormal_hepatobiliary_system	1.42345827
32	MP0000747_muscle_weakness	1.41068377
33	MP0001324_abnormal_eye_pigmentation	1.37348170
34	MP0009785_altered_susceptibility_to	1.35200498
35	MP0003111_abnormal_nucleus_morphology	1.34890042
36	MP0005220_abnormal_exocrine_pancreas	1.31091830
37	MP0010386_abnormal_urinary_bladder	1.29941475
38	MP0005395_other_phenotype	1.26437748
39	MP0001145_abnormal_male_reproductive	1.21196382
40	MP0003698_abnormal_male_reproductive	1.19145840
41	MP0005410_abnormal_fertilization	1.17788455
42	MP0000015_abnormal_ear_pigmentation	1.16714521
43	MP0005464_abnormal_platelet_physiology	1.13617320
44	MP0005451_abnormal_body_composition	1.13197091
45	MP0001663_abnormal_digestive_system	1.11435166
46	MP0001186_pigmentation_phenotype	1.09677957
47	MP0008932_abnormal_embryonic_tissue	1.06764066
48	MP0000465_gastrointestinal_hemorrhage	1.03252941
49	MP0009379_abnormal_foot_pigmentation	1.02683163
50	MP0001730_embryonic_growth_arrest	1.02299472
51	MP0003950_abnormal_plasma_membrane	1.00997763
52	MP0003221_abnormal_cardiomyocyte_apopto	1.00272024
53	MP0000653_abnormal_sex_gland	0.99758390
54	MP0002075_abnormal_coat/hair_pigmentati	0.98373794
55	MP0000350_abnormal_cell_proliferation	0.96814066
56	MP0008058_abnormal_DNA_repair	0.93357586
57	MP0005670_abnormal_white_adipose	0.92431571
58	MP0003656_abnormal_erythrocyte_physiolo	0.92341057
59	MP0001800_abnormal_humoral_immune	0.92124686
60	MP0001666_abnormal_nutrient_absorption	0.89720341
61	MP0002693_abnormal_pancreas_physiology	0.87747592
62	MP0009643_abnormal_urine_homeostasis	0.85509978
63	MP0002396_abnormal_hematopoietic_system	0.85242584
64	MP0000689_abnormal_spleen_morphology	0.84479671
65	MP0002751_abnormal_autonomic_nervous	0.84438363
66	MP0000371_diluted_coat_color	0.84021349
67	MP0003718_maternal_effect	0.83390238
68	MP0002229_neurodegeneration	0.82956047
69	MP0001664_abnormal_digestion	0.81599917
70	MP0001919_abnormal_reproductive_system	0.81328756
71	MP0001542_abnormal_bone_strength	0.80845446
72	MP0000685_abnormal_immune_system	0.80202115
73	MP0005083_abnormal_biliary_tract	0.79006535
74	MP0005389_reproductive_system_phenotype	0.78029614
75	MP0005381_digestive/alimentary_phenotyp	0.78014253
76	MP0000313_abnormal_cell_death	0.77566254
77	MP0001756_abnormal_urination	0.76574210
78	MP0003943_abnormal_hepatobiliary_system	0.76180211
79	MP0010307_abnormal_tumor_latency	0.75615954
80	MP0005266_abnormal_metabolism	0.75331947
81	MP0002398_abnormal_bone_marrow	0.75185966
82	MP0002928_abnormal_bile_duct	0.73966472
83	MP0003252_abnormal_bile_duct	0.73153723
84	MP0003045_fibrosis	0.73066320
85	MP0001835_abnormal_antigen_presentation	0.72637189
86	MP0001697_abnormal_embryo_size	0.72378142
87	MP0010094_abnormal_chromosome_stability	0.70356622
88	MP0002161_abnormal_fertility/fecundity	0.70227421
89	MP0000716_abnormal_immune_system	0.69748669
90	MP0002429_abnormal_blood_cell	0.69523924
91	MP0008007_abnormal_cellular_replicative	0.67811943
92	MP0005025_abnormal_response_to	0.67593547
93	MP0006036_abnormal_mitochondrial_physio	0.67576440
94	MP0002080_prenatal_lethality	0.66676071
95	MP0002452_abnormal_antigen_presenting	0.65789538
96	MP0006138_congestive_heart_failure	0.65434099
97	MP0005636_abnormal_mineral_homeostasis	0.62501172
98	MP0002148_abnormal_hypersensitivity_rea	0.61991985
99	MP0003868_abnormal_feces_composition	0.58917641
100	MP0004233_abnormal_muscle_weight	0.58421291

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Vacuolated lymphocytes (HP:0001922)	5.50963340
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.12320868
3	Albinism (HP:0001022)	4.08805445
4	Increased cerebral lipofuscin (HP:0011813)	4.02656725
5	Vertebral compression fractures (HP:0002953)	3.90969664
6	Large for gestational age (HP:0001520)	3.89232138
7	Abnormal auditory evoked potentials (HP:0006958)	3.88961514
8	Decreased circulating renin level (HP:0003351)	3.83394516
9	Reticulocytopenia (HP:0001896)	3.63461394
10	Abnormal protein N-linked glycosylation (HP:0012347)	3.51595829
11	Abnormal protein glycosylation (HP:0012346)	3.51595829
12	Abnormal glycosylation (HP:0012345)	3.51595829
13	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.51595829
14	Patchy hypopigmentation of hair (HP:0011365)	3.50741745
15	Dysostosis multiplex (HP:0000943)	3.38539802
16	Type I transferrin isoform profile (HP:0003642)	3.37297100
17	Reduced antithrombin III activity (HP:0001976)	3.37073523
18	Hyperactive renin-angiotensin system (HP:0000841)	3.35497933
19	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.33491713
20	Abnormality of liposaccharide metabolism (HP:0010968)	3.28058651
21	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.28058651
22	Abnormality of glycolipid metabolism (HP:0010969)	3.28058651
23	Abnormality of cells of the erythroid lineage (HP:0012130)	3.17505922
24	Abnormality of the columella (HP:0009929)	3.16898645
25	Abnormal number of erythroid precursors (HP:0012131)	3.07443940
26	Thoracolumbar scoliosis (HP:0002944)	2.94956718
27	Abnormal tarsal ossification (HP:0008369)	2.84226971
28	Increased IgM level (HP:0003496)	2.80761054
29	Spastic paraparesis (HP:0002313)	2.75104829
30	Carpal bone hypoplasia (HP:0001498)	2.72738045
31	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.65750829
32	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.63285878
33	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.63285878
34	White forelock (HP:0002211)	2.63241674
35	Short middle phalanx of the 5th finger (HP:0004220)	2.61181896
36	Cerebral hypomyelination (HP:0006808)	2.58426837
37	Acute hepatic failure (HP:0006554)	2.56757779
38	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.47830245
39	Hypokalemic alkalosis (HP:0001949)	2.41433515
40	Lower limb hyperreflexia (HP:0002395)	2.40568915
41	Chronic bronchitis (HP:0004469)	2.40039739
42	Abnormality of the lumbar spine (HP:0100712)	2.38391936
43	Overlapping toe (HP:0001845)	2.37483366
44	Premature graying of hair (HP:0002216)	2.36442176
45	Dry hair (HP:0011359)	2.36397405
46	Autoimmune hemolytic anemia (HP:0001890)	2.35610203
47	Onycholysis (HP:0001806)	2.34365305
48	Upper limb muscle weakness (HP:0003484)	2.29226463
49	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.26938590
50	Microretrognathia (HP:0000308)	2.25159861
51	Tetraparesis (HP:0002273)	2.22840173
52	Progressive visual loss (HP:0000529)	2.22708553
53	3-Methylglutaconic aciduria (HP:0003535)	2.20183390
54	Hyperlipoproteinemia (HP:0010980)	2.19728890
55	Abnormality of incisor morphology (HP:0011063)	2.18978839
56	CNS hypomyelination (HP:0003429)	2.18920393
57	Generalized hypopigmentation (HP:0007513)	2.18839721
58	Thoracic kyphosis (HP:0002942)	2.18273925
59	Beaking of vertebral bodies (HP:0004568)	2.17454638
60	Exocrine pancreatic insufficiency (HP:0001738)	2.17314620
61	Premature ovarian failure (HP:0008209)	2.17066032
62	Hyponatremia (HP:0002902)	2.15716663
63	Abolished electroretinogram (ERG) (HP:0000550)	2.12375186
64	Severe visual impairment (HP:0001141)	2.07751274
65	Abnormality of the distal phalanges of the toes (HP:0010182)	2.07316315
66	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.06575960
67	Hyperkalemia (HP:0002153)	2.06197256
68	Volvulus (HP:0002580)	2.04830268
69	Abnormality of the renal collecting system (HP:0004742)	2.03342269
70	Prolonged neonatal jaundice (HP:0006579)	2.02915600
71	Conical tooth (HP:0000698)	2.01066828
72	Duplicated collecting system (HP:0000081)	1.99519979
73	Ankyloglossia (HP:0010296)	1.98736653
74	Increased CSF lactate (HP:0002490)	1.98483780
75	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98316641
76	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98316641
77	Progressive microcephaly (HP:0000253)	1.98115961
78	Abnormality of macular pigmentation (HP:0008002)	1.95910489
79	Syringomyelia (HP:0003396)	1.92072130
80	Spinal cord lesions (HP:0100561)	1.92072130
81	Ridged nail (HP:0001807)	1.92070470
82	Hypercortisolism (HP:0001578)	1.91992668
83	Chromsome breakage (HP:0040012)	1.90432279
84	Blepharitis (HP:0000498)	1.90362110
85	Abnormal foot bone ossification (HP:0010675)	1.90205517
86	Hypopigmentation of the fundus (HP:0007894)	1.89933343
87	Abnormality of the thoracic spine (HP:0100711)	1.88785316
88	J-shaped sella turcica (HP:0002680)	1.88349063
89	Pallor (HP:0000980)	1.85548038
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84939963
91	Macrocytic anemia (HP:0001972)	1.84220006
92	Abnormality of macrophages (HP:0004311)	1.84159951
93	Small epiphyses (HP:0010585)	1.82795345
94	Long eyelashes (HP:0000527)	1.82772475
95	Abnormality of T cell physiology (HP:0011840)	1.82672988
96	Petechiae (HP:0000967)	1.77162144
97	Paraparesis (HP:0002385)	1.74951693
98	Mitochondrial inheritance (HP:0001427)	1.74346347
99	Abnormality of the frontal sinuses (HP:0002687)	1.74293692
100	Unilateral renal agenesis (HP:0000122)	1.74003851

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	5.30505070
2	EIF2AK3	4.92453372
3	INSRR	3.95092800
4	TESK2	3.77046676
5	TAOK2	3.34508661
6	CDK19	3.22304893
7	ARAF	3.17815202
8	ITK	2.51993846
9	MAP3K9	2.43222063
10	NME2	2.35812705
11	BRAF	2.31583665
12	LATS1	2.30739589
13	KSR2	2.30456390
14	TAF1	2.28606395
15	BUB1	2.27811834
16	ERN1	2.06673692
17	MUSK	2.05266723
18	SCYL2	2.04360630
19	MAP3K12	1.96936681
20	IRAK3	1.89329371
21	CDK3	1.54543338
22	STK16	1.46612430
23	RAF1	1.30830203
24	PBK	1.26609339
25	MAPK7	1.23351850
26	MAP3K10	1.22497505
27	BRSK1	1.09934237
28	KDR	1.05880541
29	EEF2K	1.04948390
30	WEE1	1.03284457
31	NME1	1.02731497
32	MOS	0.99256282
33	BLK	0.97081126
34	ACVR1B	0.97062887
35	AKT2	0.85709997
36	KSR1	0.84901494
37	PLK4	0.84317729
38	EIF2AK1	0.82513707
39	OXSR1	0.80686742
40	MAP3K13	0.78548950
41	MAP3K1	0.76018262
42	MAP3K8	0.68091121
43	CDK11A	0.68044912
44	AURKA	0.67640187
45	CSNK2A1	0.66511325
46	DAPK2	0.64243356
47	MARK3	0.63624114
48	PAK1	0.63322111
49	MAPK12	0.62721244
50	ICK	0.62544513
51	SRPK1	0.62208818
52	STK10	0.58680144
53	CHEK1	0.58083752
54	TTK	0.57070507
55	CSF1R	0.56820755
56	BMPR1B	0.56600940
57	CDK15	0.54969554
58	CDK18	0.52960767
59	CDK14	0.52864503
60	TYK2	0.52137376
61	CDK8	0.52119290
62	MAP3K5	0.51448661
63	NEK2	0.51300658
64	LRRK2	0.51180217
65	CDC7	0.49908074
66	IRAK2	0.47917042
67	CDK7	0.47890192
68	PIM1	0.47335063
69	CHEK2	0.46988380
70	TESK1	0.45082048
71	MAP4K1	0.45071548
72	MAP2K2	0.43436653
73	PDK1	0.41642628
74	RPS6KB1	0.41018873
75	DYRK1B	0.40684187
76	PDPK1	0.38973205
77	TRIM28	0.38465080
78	NEK1	0.36806426
79	IRAK4	0.36040049
80	GRK6	0.34425976
81	MAP3K14	0.33889300
82	CSNK2A2	0.33863275
83	CSNK1G2	0.33857531
84	TBK1	0.32106121
85	IKBKB	0.30584087
86	STK3	0.28325182
87	CSNK1G3	0.27699438
88	RPS6KL1	0.27344251
89	RPS6KC1	0.27344251
90	MAP3K11	0.26467613
91	JAK2	0.26399863
92	AURKB	0.26178419
93	RPS6KA6	0.25774800
94	RPS6KA5	0.25105501
95	PRKCI	0.25090095
96	TAOK3	0.24734080
97	CDK1	0.23187288
98	PAK4	0.22000970
99	ATR	0.21519453
100	MYLK	0.21350520

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	N-Glycan biosynthesis_Homo sapiens_hsa00510	4.70924427
2	Ribosome_Homo sapiens_hsa03010	4.16915142
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.56908930
4	Proteasome_Homo sapiens_hsa03050	3.43115103
5	Protein export_Homo sapiens_hsa03060	2.97298484
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.86564660
7	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.77973354
8	DNA replication_Homo sapiens_hsa03030	2.61496244
9	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.31578302
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.26931033
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.20895238
12	Mismatch repair_Homo sapiens_hsa03430	2.05686042
13	Collecting duct acid secretion_Homo sapiens_hsa04966	2.03072739
14	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.01335055
15	Bladder cancer_Homo sapiens_hsa05219	1.96362218
16	Vibrio cholerae infection_Homo sapiens_hsa05110	1.87221596
17	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.81905036
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72244229
19	Parkinsons disease_Homo sapiens_hsa05012	1.65859237
20	RNA transport_Homo sapiens_hsa03013	1.60784779
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.55633458
22	One carbon pool by folate_Homo sapiens_hsa00670	1.52477617
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.45629237
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45327820
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.42061929
26	Allograft rejection_Homo sapiens_hsa05330	1.41018453
27	Lysosome_Homo sapiens_hsa04142	1.40673771
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.39752131
29	Prion diseases_Homo sapiens_hsa05020	1.38961048
30	Alzheimers disease_Homo sapiens_hsa05010	1.36597521
31	mRNA surveillance pathway_Homo sapiens_hsa03015	1.35436765
32	RNA polymerase_Homo sapiens_hsa03020	1.34900051
33	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.23421892
34	Sulfur metabolism_Homo sapiens_hsa00920	1.20914463
35	Huntingtons disease_Homo sapiens_hsa05016	1.18975365
36	Viral myocarditis_Homo sapiens_hsa05416	1.18921804
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17200013
38	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.15542545
39	Homologous recombination_Homo sapiens_hsa03440	1.13255564
40	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.09319450
41	Other glycan degradation_Homo sapiens_hsa00511	1.06104782
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.00019630
43	Cell cycle_Homo sapiens_hsa04110	0.98543890
44	Base excision repair_Homo sapiens_hsa03410	0.98529994
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.96685767
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.90102635
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87618503
48	Non-small cell lung cancer_Homo sapiens_hsa05223	0.86039324
49	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.84111476
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.83511958
51	Acute myeloid leukemia_Homo sapiens_hsa05221	0.82277751
52	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.81775579
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79300216
54	Spliceosome_Homo sapiens_hsa03040	0.76498291
55	Pancreatic cancer_Homo sapiens_hsa05212	0.75701932
56	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.74126602
57	Antigen processing and presentation_Homo sapiens_hsa04612	0.70878671
58	Basal transcription factors_Homo sapiens_hsa03022	0.69521525
59	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.69516373
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68139116
61	Measles_Homo sapiens_hsa05162	0.67949023
62	Purine metabolism_Homo sapiens_hsa00230	0.63656772
63	Prostate cancer_Homo sapiens_hsa05215	0.63114388
64	Fatty acid elongation_Homo sapiens_hsa00062	0.62871989
65	Hepatitis B_Homo sapiens_hsa05161	0.62008477
66	Melanoma_Homo sapiens_hsa05218	0.56544628
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55575669
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54325092
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52784396
70	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50591763
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49314671
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.49246741
73	Cardiac muscle contraction_Homo sapiens_hsa04260	0.46154394
74	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.43104234
75	Herpes simplex infection_Homo sapiens_hsa05168	0.42651176
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.41936860
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.40830530
78	Apoptosis_Homo sapiens_hsa04210	0.40335646
79	Phagosome_Homo sapiens_hsa04145	0.37835062
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36952491
81	Glioma_Homo sapiens_hsa05214	0.36850077
82	Metabolic pathways_Homo sapiens_hsa01100	0.35545066
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33392395
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.33245213
85	RNA degradation_Homo sapiens_hsa03018	0.32783600
86	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28795358
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27392331
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.26350392
89	Oocyte meiosis_Homo sapiens_hsa04114	0.26252376
90	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.25699292
91	Sulfur relay system_Homo sapiens_hsa04122	0.25644163
92	HTLV-I infection_Homo sapiens_hsa05166	0.25554339
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23826985
94	Viral carcinogenesis_Homo sapiens_hsa05203	0.22111324
95	Taste transduction_Homo sapiens_hsa04742	0.21949284
96	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.16229843
97	Thyroid cancer_Homo sapiens_hsa05216	0.15889512
98	Endocytosis_Homo sapiens_hsa04144	0.15627143
99	Folate biosynthesis_Homo sapiens_hsa00790	0.15585710
100	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.14136903

TSPY10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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