ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of meiosis I (GO:0060631)	7.31334923
2	piRNA metabolic process (GO:0034587)	7.13489650
3	* mesoderm development (GO:0007498)	6.26335219
4	* mesenchyme development (GO:0060485)	6.00109656
5	sex differentiation (GO:0007548)	5.79756485
6	* gonadal mesoderm development (GO:0007506)	46.1260251
7	positive regulation of meiosis (GO:0045836)	4.67374592
8	ribosomal small subunit assembly (GO:0000028)	4.60929641
9	ncRNA 3-end processing (GO:0043628)	4.60057825
10	positive regulation of meiotic cell cycle (GO:0051446)	4.54195804
11	regulation of activation of Janus kinase activity (GO:0010533)	4.10106925
12	* nucleosome assembly (GO:0006334)	4.02933529
13	folic acid transport (GO:0015884)	3.95638285
14	male meiosis (GO:0007140)	3.88681443
15	synapsis (GO:0007129)	3.86563220
16	nucleotide transmembrane transport (GO:1901679)	3.81869211
17	male meiosis I (GO:0007141)	3.76166537
18	* protein-DNA complex assembly (GO:0065004)	3.66428223
19	positive regulation of translational initiation (GO:0045948)	3.44421207
20	gene silencing by RNA (GO:0031047)	3.43613099
21	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.38371451
22	meiosis I (GO:0007127)	3.38131255
23	negative regulation of meiosis (GO:0045835)	3.34626901
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.30700866
25	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.30700866
26	* nucleosome organization (GO:0034728)	3.26548049
27	N-acetylneuraminate metabolic process (GO:0006054)	3.24982104
28	DNA catabolic process, exonucleolytic (GO:0000738)	3.13588549
29	oogenesis (GO:0048477)	3.07150840
30	ribosomal small subunit biogenesis (GO:0042274)	3.06435411
31	* protein-DNA complex subunit organization (GO:0071824)	3.05781596
32	regulation of meiosis (GO:0040020)	3.02071070
33	chromosome organization involved in meiosis (GO:0070192)	2.96487448
34	meiotic chromosome segregation (GO:0045132)	2.95785863
35	germ cell migration (GO:0008354)	2.93699392
36	meiotic nuclear division (GO:0007126)	2.87179962
37	lymphangiogenesis (GO:0001946)	2.81980902
38	ear development (GO:0043583)	2.81301227
39	nucleotide transport (GO:0006862)	2.81071438
40	synaptonemal complex assembly (GO:0007130)	2.76239390
41	one-carbon compound transport (GO:0019755)	2.76071492
42	CENP-A containing nucleosome assembly (GO:0034080)	2.72066508
43	regulation of sister chromatid cohesion (GO:0007063)	2.69541461
44	negative regulation of gene silencing (GO:0060969)	2.69247376
45	proteasome assembly (GO:0043248)	2.68844359
46	DNA double-strand break processing (GO:0000729)	2.68609715
47	mitotic chromosome condensation (GO:0007076)	2.63300501
48	DNA methylation involved in gamete generation (GO:0043046)	2.63179557
49	chromatin remodeling at centromere (GO:0031055)	2.61761487
50	regulation of meiotic cell cycle (GO:0051445)	2.59394540
51	viral transcription (GO:0019083)	2.57332514
52	synaptonemal complex organization (GO:0070193)	2.54841772
53	translational termination (GO:0006415)	2.54161474
54	meiotic cell cycle (GO:0051321)	2.51186432
55	regulation of fibroblast apoptotic process (GO:2000269)	2.46368299
56	mitotic sister chromatid cohesion (GO:0007064)	2.45699675
57	meiotic cell cycle process (GO:1903046)	2.43761923
58	resolution of meiotic recombination intermediates (GO:0000712)	2.38390282
59	positive regulation of viral genome replication (GO:0045070)	2.35575092
60	sister chromatid cohesion (GO:0007062)	2.33845836
61	fat-soluble vitamin biosynthetic process (GO:0042362)	2.32281934
62	female gamete generation (GO:0007292)	2.32012020
63	formation of translation preinitiation complex (GO:0001731)	2.31926676
64	translational elongation (GO:0006414)	2.30446331
65	histone exchange (GO:0043486)	2.29215193
66	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.25847376
67	G2 DNA damage checkpoint (GO:0031572)	2.22999819
68	cotranslational protein targeting to membrane (GO:0006613)	2.20057841
69	establishment of integrated proviral latency (GO:0075713)	2.18303757
70	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.17892105
71	blastocyst development (GO:0001824)	2.17508790
72	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.14030985
73	DNA replication-independent nucleosome assembly (GO:0006336)	2.13037369
74	DNA replication-independent nucleosome organization (GO:0034724)	2.13037369
75	protein targeting to ER (GO:0045047)	2.12332884
76	* male gamete generation (GO:0048232)	2.11682254
77	telomere maintenance via semi-conservative replication (GO:0032201)	2.10894117
78	protein localization to endoplasmic reticulum (GO:0070972)	2.10444786
79	* spermatogenesis (GO:0007283)	2.10420147
80	viral life cycle (GO:0019058)	2.09830685
81	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.07796109
82	protein K6-linked ubiquitination (GO:0085020)	2.06837642
83	negative regulation of meiotic cell cycle (GO:0051447)	2.05978910
84	cellular response to interleukin-15 (GO:0071350)	2.04754265
85	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.04347283
86	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.03972853
87	histone mRNA metabolic process (GO:0008334)	2.03896783
88	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.03695759
89	translational initiation (GO:0006413)	2.03459610
90	DNA-dependent DNA replication (GO:0006261)	2.03038524
91	response to UV-B (GO:0010224)	2.02382322
92	hepatocyte apoptotic process (GO:0097284)	1.99645900
93	RNA phosphodiester bond hydrolysis (GO:0090501)	1.95832754
94	regulation of regulatory T cell differentiation (GO:0045589)	1.95640395
95	N-terminal protein amino acid acetylation (GO:0006474)	1.95520376
96	* gamete generation (GO:0007276)	1.94569511
97	vitamin D metabolic process (GO:0042359)	1.94132925
98	protein-cofactor linkage (GO:0018065)	1.92664921
99	cellular protein complex disassembly (GO:0043624)	1.89876995
100	positive regulation of mitochondrial fission (GO:0090141)	1.89398607

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.36788907
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.01824554
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.78558852
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.70634266
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.59218469
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.42702271
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36023806
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.16454688
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92850722
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.75561341
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.72696191
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.68214845
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.67362217
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.63299465
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.58772209
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.58710581
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.42129167
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.37327751
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26536231
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.25715833
21	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.23122413
22	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.21451944
23	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.13410816
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11082549
25	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.07307702
26	ELK1_19687146_ChIP-ChIP_HELA_Human	2.04091848
27	TTF2_22483619_ChIP-Seq_HELA_Human	2.02379160
28	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.01090986
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.00414627
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.98665381
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.97651673
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.96582844
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.95897467
34	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.91777352
35	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.91777352
36	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.91777352
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.88967705
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.79682842
39	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.77563231
40	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.77015845
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.74599429
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69512749
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.69406745
44	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.68549107
45	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.67728558
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67180047
47	TFEB_21752829_ChIP-Seq_HELA_Human	1.64144844
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.62993253
49	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.62920818
50	VDR_22108803_ChIP-Seq_LS180_Human	1.55732127
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53758964
52	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.49991270
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.49769533
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44818027
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.38852553
56	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.38687390
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.30466106
58	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.29220795
59	ZNF263_19887448_ChIP-Seq_K562_Human	1.23632175
60	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.21325709
61	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.20519202
62	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.20491698
63	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16812150
64	MYB_26560356_Chip-Seq_TH2_Human	1.14087293
65	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.11273414
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10474262
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05554607
68	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.05165717
69	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04797319
70	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.04689369
71	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02960266
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99704080
73	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.99493059
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98964356
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98814140
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.96634661
77	GATA3_26560356_Chip-Seq_TH1_Human	0.96606902
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95533402
79	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92901721
80	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92894159
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.90249695
82	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.88934228
83	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.86686562
84	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.86360793
85	MYC_18940864_ChIP-ChIP_HL60_Human	0.84063530
86	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.83971434
87	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.83342697
88	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.83161335
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.80483408
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.79485857
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.79485857
92	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.78060875
93	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.77667534
94	XRN2_22483619_ChIP-Seq_HELA_Human	0.77506249
95	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.77000810
96	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.75426007
97	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.74528457
98	TP53_22573176_ChIP-Seq_HFKS_Human	0.74207856
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.73951807
100	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.73144921

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	5.98352049
2	MP0003136_yellow_coat_color	3.67909206
3	MP0003806_abnormal_nucleotide_metabolis	3.58309743
4	MP0008877_abnormal_DNA_methylation	3.49542172
5	MP0003693_abnormal_embryo_hatching	3.12377003
6	MP0002163_abnormal_gland_morphology	3.08820709
7	MP0004147_increased_porphyrin_level	3.04347617
8	MP0000372_irregular_coat_pigmentation	2.83573287
9	MP0005174_abnormal_tail_pigmentation	2.78857002
10	MP0004957_abnormal_blastocyst_morpholog	2.67400280
11	MP0005671_abnormal_response_to	2.67399013
12	MP0005075_abnormal_melanosome_morpholog	2.61219840
13	MP0003303_peritoneal_inflammation	2.42638183
14	MP0005379_endocrine/exocrine_gland_phen	2.32770681
15	MP0010094_abnormal_chromosome_stability	2.17660573
16	MP0002210_abnormal_sex_determination	2.10027539
17	MP0001879_abnormal_lymphatic_vessel	2.05949397
18	MP0001929_abnormal_gametogenesis	1.98553215
19	MP0005451_abnormal_body_composition	1.98310264
20	MP0010307_abnormal_tumor_latency	1.94504746
21	MP0008057_abnormal_DNA_replication	1.90795198
22	MP0003646_muscle_fatigue	1.86732021
23	MP0005408_hypopigmentation	1.85640241
24	MP0005367_renal/urinary_system_phenotyp	1.84837649
25	MP0000516_abnormal_urinary_system	1.84837649
26	MP0001145_abnormal_male_reproductive	1.74175103
27	MP0002877_abnormal_melanocyte_morpholog	1.72511361
28	MP0009379_abnormal_foot_pigmentation	1.70466011
29	MP0008995_early_reproductive_senescence	1.69966302
30	MP0001177_atelectasis	1.63300975
31	MP0003786_premature_aging	1.63010770
32	MP0009333_abnormal_splenocyte_physiolog	1.62490478
33	MP0003183_abnormal_peptide_metabolism	1.57281282
34	MP0003763_abnormal_thymus_physiology	1.55309416
35	MP0000653_abnormal_sex_gland	1.52410209
36	MP0002796_impaired_skin_barrier	1.48013235
37	MP0008932_abnormal_embryonic_tissue	1.46101982
38	MP0001873_stomach_inflammation	1.40334967
39	MP0003077_abnormal_cell_cycle	1.38828093
40	MP0002837_dystrophic_cardiac_calcinosis	1.38033404
41	MP0003698_abnormal_male_reproductive	1.35552915
42	MP0005058_abnormal_lysosome_morphology	1.32477619
43	MP0003186_abnormal_redox_activity	1.31944233
44	MP0008058_abnormal_DNA_repair	1.31224075
45	MP0003252_abnormal_bile_duct	1.27198971
46	MP0002277_abnormal_respiratory_mucosa	1.26633941
47	MP0002095_abnormal_skin_pigmentation	1.20932556
48	MP0001853_heart_inflammation	1.20657980
49	MP0002160_abnormal_reproductive_system	1.20184352
50	MP0001188_hyperpigmentation	1.16122566
51	MP0000350_abnormal_cell_proliferation	1.14775501
52	MP0003718_maternal_effect	1.13810917
53	MP0004782_abnormal_surfactant_physiolog	1.12956625
54	MP0000371_diluted_coat_color	1.12948923
55	MP0001666_abnormal_nutrient_absorption	1.08001446
56	MP0003111_abnormal_nucleus_morphology	1.07512438
57	MP0005670_abnormal_white_adipose	1.05708533
58	MP0004381_abnormal_hair_follicle	1.05428713
59	MP0003959_abnormal_lean_body	1.05427625
60	MP0000569_abnormal_digit_pigmentation	1.02345835
61	MP0000490_abnormal_crypts_of	1.01073888
62	MP0005171_absent_coat_pigmentation	1.00626346
63	MP0001730_embryonic_growth_arrest	1.00169480
64	MP0002009_preneoplasia	0.99430658
65	MP0002075_abnormal_coat/hair_pigmentati	0.98313512
66	MP0010155_abnormal_intestine_physiology	0.97941499
67	MP0005389_reproductive_system_phenotype	0.97579893
68	MP0008004_abnormal_stomach_pH	0.97025705
69	MP0005501_abnormal_skin_physiology	0.95955499
70	MP0001348_abnormal_lacrimal_gland	0.94522543
71	MP0005310_abnormal_salivary_gland	0.92685716
72	MP0003943_abnormal_hepatobiliary_system	0.88266447
73	MP0008007_abnormal_cellular_replicative	0.87907656
74	MP0004197_abnormal_fetal_growth/weight/	0.86841790
75	MP0002638_abnormal_pupillary_reflex	0.86772007
76	MP0000358_abnormal_cell_content/	0.85376300
77	MP0005410_abnormal_fertilization	0.85342286
78	MP0005395_other_phenotype	0.80990810
79	MP0001663_abnormal_digestive_system	0.79776393
80	MP0000313_abnormal_cell_death	0.76674674
81	MP0005464_abnormal_platelet_physiology	0.76008792
82	MP0003448_altered_tumor_morphology	0.74624644
83	MP0001697_abnormal_embryo_size	0.72652085
84	MP0002161_abnormal_fertility/fecundity	0.71264550
85	MP0002080_prenatal_lethality	0.69913051
86	MP0009840_abnormal_foam_cell	0.69693537
87	MP0000920_abnormal_myelination	0.69562070
88	MP0002398_abnormal_bone_marrow	0.69505145
89	MP0000343_altered_response_to	0.69354051
90	MP0000015_abnormal_ear_pigmentation	0.68812678
91	MP0001119_abnormal_female_reproductive	0.68682257
92	MP0001186_pigmentation_phenotype	0.66693632
93	MP0001800_abnormal_humoral_immune	0.63672324
94	MP0000462_abnormal_digestive_system	0.61692863
95	MP0003880_abnormal_central_pattern	0.59185835
96	MP0005381_digestive/alimentary_phenotyp	0.58720959
97	MP0004215_abnormal_myocardial_fiber	0.58152734
98	MP0009785_altered_susceptibility_to	0.57987337
99	MP0001919_abnormal_reproductive_system	0.57788504
100	MP0002148_abnormal_hypersensitivity_rea	0.57715220

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the costochondral junction (HP:0000919)	4.56979072
2	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.38982787
3	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.38982787
4	Carpal bone hypoplasia (HP:0001498)	4.08203883
5	Reticulocytopenia (HP:0001896)	3.59895605
6	Chronic diarrhea (HP:0002028)	3.57625053
7	Microvesicular hepatic steatosis (HP:0001414)	3.54127483
8	Abnormality of the corticospinal tract (HP:0002492)	3.43762496
9	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.34422469
10	Type I transferrin isoform profile (HP:0003642)	3.27458706
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.27195048
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.27195048
13	Delayed epiphyseal ossification (HP:0002663)	3.20606390
14	Abnormality of the renal collecting system (HP:0004742)	3.10067177
15	Squamous cell carcinoma (HP:0002860)	3.08229786
16	Increased hepatocellular lipid droplets (HP:0006565)	3.05756094
17	Lipid accumulation in hepatocytes (HP:0006561)	3.03763519
18	Abnormal protein glycosylation (HP:0012346)	3.03444540
19	Abnormal glycosylation (HP:0012345)	3.03444540
20	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.03444540
21	Abnormal protein N-linked glycosylation (HP:0012347)	3.03444540
22	Abnormality of DNA repair (HP:0003254)	2.97920553
23	Abnormality of T cell number (HP:0011839)	2.94843561
24	Abnormality of T cell physiology (HP:0011840)	2.92606046
25	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.83945642
26	Duplicated collecting system (HP:0000081)	2.82166845
27	Reduced antithrombin III activity (HP:0001976)	2.78296853
28	T lymphocytopenia (HP:0005403)	2.78227356
29	Abnormality of T cells (HP:0002843)	2.78189818
30	Chromsome breakage (HP:0040012)	2.76016597
31	Enlarged epiphyses (HP:0010580)	2.73151237
32	Hyperglycinuria (HP:0003108)	2.62162242
33	Increased CSF lactate (HP:0002490)	2.59593690
34	Patchy hypopigmentation of hair (HP:0011365)	2.59341585
35	Thin bony cortex (HP:0002753)	2.52126800
36	Metaphyseal irregularity (HP:0003025)	2.49015172
37	Premature skin wrinkling (HP:0100678)	2.45767114
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.45119812
39	Volvulus (HP:0002580)	2.44311013
40	Horizontal nystagmus (HP:0000666)	2.42788378
41	Osteomalacia (HP:0002749)	2.42677477
42	Scotoma (HP:0000575)	2.40341676
43	Azoospermia (HP:0000027)	2.39587993
44	IgG deficiency (HP:0004315)	2.38970318
45	Acute necrotizing encephalopathy (HP:0006965)	2.37966622
46	Abnormality of oral frenula (HP:0000190)	2.37573129
47	Cutaneous melanoma (HP:0012056)	2.36468093
48	Abnormal auditory evoked potentials (HP:0006958)	2.36139755
49	Dysphonia (HP:0001618)	2.36062258
50	Abnormal spermatogenesis (HP:0008669)	2.34654339
51	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.34522060
52	Exocrine pancreatic insufficiency (HP:0001738)	2.31059924
53	Chronic mucocutaneous candidiasis (HP:0002728)	2.28288384
54	Recurrent cutaneous fungal infections (HP:0011370)	2.28288384
55	J-shaped sella turcica (HP:0002680)	2.25648980
56	Mitochondrial inheritance (HP:0001427)	2.24565605
57	IgA deficiency (HP:0002720)	2.21667913
58	Hyperglycinemia (HP:0002154)	2.16786248
59	White forelock (HP:0002211)	2.14746726
60	Flat occiput (HP:0005469)	2.11743791
61	Abnormal mitochondria in muscle tissue (HP:0008316)	2.09668422
62	Acute encephalopathy (HP:0006846)	2.08856792
63	Ectopic kidney (HP:0000086)	2.07629235
64	Poikiloderma (HP:0001029)	2.07530248
65	IgM deficiency (HP:0002850)	2.07114303
66	Basal cell carcinoma (HP:0002671)	2.06414114
67	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.06266082
68	Short tibia (HP:0005736)	2.04604929
69	Death in childhood (HP:0003819)	2.03397502
70	Hypercortisolism (HP:0001578)	2.01222086
71	Severe global developmental delay (HP:0011344)	2.01219327
72	Cerebral edema (HP:0002181)	2.00691502
73	Neoplasm of head and neck (HP:0012288)	2.00648547
74	Esophageal neoplasm (HP:0100751)	2.00648547
75	Vacuolated lymphocytes (HP:0001922)	2.00542193
76	Horseshoe kidney (HP:0000085)	2.00267060
77	Macrocytic anemia (HP:0001972)	2.00112343
78	Progressive inability to walk (HP:0002505)	2.00048984
79	Widely patent fontanelles and sutures (HP:0004492)	1.99473282
80	Progressive microcephaly (HP:0000253)	1.94834410
81	Retinal dysplasia (HP:0007973)	1.94307317
82	Septate vagina (HP:0001153)	1.94146587
83	Asplenia (HP:0001746)	1.92784645
84	Autoimmune hemolytic anemia (HP:0001890)	1.89443233
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88821998
86	Abnormality of glycine metabolism (HP:0010895)	1.88821998
87	Progressive macrocephaly (HP:0004481)	1.88167843
88	Gonadal dysgenesis (HP:0000133)	1.87732887
89	Rimmed vacuoles (HP:0003805)	1.86821831
90	Micronodular cirrhosis (HP:0001413)	1.84979482
91	Deformed sella turcica (HP:0002681)	1.84022676
92	Hypoproteinemia (HP:0003075)	1.83386244
93	Abnormality of pyrimidine metabolism (HP:0004353)	1.79179693
94	Hyperlipoproteinemia (HP:0010980)	1.78349953
95	Beaking of vertebral bodies (HP:0004568)	1.76486256
96	Rickets (HP:0002748)	1.76281552
97	Paralysis (HP:0003470)	1.74071565
98	Testicular atrophy (HP:0000029)	1.73462100
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.73025138
100	Sparse eyelashes (HP:0000653)	1.72429545

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	8.89158104
2	TXK	5.74969004
3	CDK19	5.08913401
4	WNK4	2.81515764
5	TTK	2.78961157
6	PLK4	2.72190789
7	STK39	2.63812479
8	PBK	2.27689675
9	PNCK	2.15533859
10	EIF2AK3	1.99659114
11	ARAF	1.91214667
12	BCR	1.82354480
13	BRAF	1.74693431
14	KSR2	1.62752166
15	WEE1	1.40917746
16	ITK	1.36490173
17	BUB1	1.35744586
18	NEK9	1.30312267
19	MATK	1.28606986
20	SCYL2	1.15099697
21	OXSR1	1.12271880
22	NME1	1.01706710
23	RAF1	0.98181829
24	MAP3K2	0.95786343
25	PIM1	0.93253245
26	CDC7	0.92813833
27	NTRK3	0.90661432
28	CDK8	0.88501975
29	PASK	0.83560627
30	EPHA4	0.83419885
31	MAPK11	0.82985386
32	TEC	0.81935814
33	ZAK	0.81474317
34	KSR1	0.81416116
35	BRSK1	0.80208970
36	TAF1	0.79863025
37	PRPF4B	0.78430147
38	PLK1	0.76831144
39	KIT	0.76342705
40	STK16	0.75153970
41	DAPK2	0.74985508
42	PRKCQ	0.74453262
43	MAP3K9	0.72155639
44	CDK3	0.71106309
45	STK10	0.69904757
46	ATR	0.68015385
47	TAOK2	0.64364982
48	CSNK1G2	0.62725775
49	MAP3K8	0.62389685
50	MARK3	0.59975226
51	NME2	0.55339335
52	BMPR1B	0.54780172
53	ADRBK2	0.54756888
54	MAP3K14	0.54530983
55	PHKG2	0.54289416
56	PHKG1	0.54289416
57	STK24	0.51469181
58	ABL2	0.48350209
59	CHEK1	0.48185049
60	MAP3K1	0.47790841
61	WNK1	0.47573684
62	AURKA	0.46825356
63	NEK6	0.46454774
64	CHEK2	0.46114188
65	GRK7	0.44684605
66	PIM2	0.43780915
67	CDK7	0.42216199
68	TYRO3	0.41139125
69	TRIM28	0.40511648
70	TIE1	0.35956489
71	ATM	0.35039179
72	RPS6KB1	0.35034703
73	CDK11A	0.34975625
74	MAP3K13	0.34911801
75	CSNK2A1	0.34066369
76	VRK2	0.33905716
77	LYN	0.33849998
78	KDR	0.33013263
79	TGFBR1	0.31689142
80	AURKB	0.31385341
81	JAK2	0.31148733
82	CSNK2A2	0.28710204
83	CSNK1G1	0.28428483
84	BCKDK	0.27806213
85	MAP3K12	0.26481198
86	RPS6KB2	0.25701614
87	ERBB4	0.25564494
88	CDK14	0.24515803
89	GRK6	0.23552781
90	VRK1	0.22371785
91	INSRR	0.22198664
92	PRKCG	0.21868152
93	SYK	0.21863627
94	PLK2	0.21263393
95	CSNK1G3	0.21160053
96	LCK	0.19008800
97	STK38L	0.18672738
98	PRKACA	0.16826880
99	PRKCI	0.16343046
100	CDK1	0.16113526

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.87906568
2	DNA replication_Homo sapiens_hsa03030	3.81525978
3	Homologous recombination_Homo sapiens_hsa03440	3.21351580
4	Mismatch repair_Homo sapiens_hsa03430	3.06046527
5	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.90043587
6	Nucleotide excision repair_Homo sapiens_hsa03420	2.40934292
7	Base excision repair_Homo sapiens_hsa03410	2.39883132
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.20211694
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.19929810
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.19018773
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.18552952
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.14737786
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12815292
14	Rheumatoid arthritis_Homo sapiens_hsa05323	2.08022159
15	p53 signaling pathway_Homo sapiens_hsa04115	2.03748802
16	RNA transport_Homo sapiens_hsa03013	1.95014030
17	Folate biosynthesis_Homo sapiens_hsa00790	1.94473959
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92195551
19	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.91733448
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.90184058
21	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.76744001
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.72236755
23	Basal transcription factors_Homo sapiens_hsa03022	1.70959998
24	Cell cycle_Homo sapiens_hsa04110	1.70778402
25	Protein export_Homo sapiens_hsa03060	1.67172844
26	Proteasome_Homo sapiens_hsa03050	1.65713361
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60937860
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.59300628
29	RNA degradation_Homo sapiens_hsa03018	1.48548983
30	Allograft rejection_Homo sapiens_hsa05330	1.47806863
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.47618511
32	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.42862704
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.40514472
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.40232388
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39733648
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.27338805
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.26718202
38	Parkinsons disease_Homo sapiens_hsa05012	1.24644969
39	One carbon pool by folate_Homo sapiens_hsa00670	1.22430693
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.12121213
41	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08891706
42	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.04616713
43	Alzheimers disease_Homo sapiens_hsa05010	0.97674993
44	Regulation of autophagy_Homo sapiens_hsa04140	0.97115061
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.95847020
46	Vibrio cholerae infection_Homo sapiens_hsa05110	0.95263868
47	RNA polymerase_Homo sapiens_hsa03020	0.94335989
48	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.91276971
49	Huntingtons disease_Homo sapiens_hsa05016	0.85813430
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.85651347
51	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.82255884
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80760870
53	Viral myocarditis_Homo sapiens_hsa05416	0.78141265
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76223179
55	Bladder cancer_Homo sapiens_hsa05219	0.75026994
56	Purine metabolism_Homo sapiens_hsa00230	0.72800896
57	Lysosome_Homo sapiens_hsa04142	0.71561063
58	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.71441877
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70179685
60	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.68985367
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66045565
62	Fatty acid elongation_Homo sapiens_hsa00062	0.65503677
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.65371971
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.64480805
65	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63714881
66	ABC transporters_Homo sapiens_hsa02010	0.61989576
67	Sulfur metabolism_Homo sapiens_hsa00920	0.61942775
68	Oocyte meiosis_Homo sapiens_hsa04114	0.60411574
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.57549911
70	Metabolic pathways_Homo sapiens_hsa01100	0.53909242
71	HTLV-I infection_Homo sapiens_hsa05166	0.52443751
72	Endocytosis_Homo sapiens_hsa04144	0.49491186
73	Spliceosome_Homo sapiens_hsa03040	0.49192482
74	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.47785486
75	Shigellosis_Homo sapiens_hsa05131	0.46760457
76	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45271008
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41738592
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.39703182
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39283612
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.35619366
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35210222
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.34565253
83	Measles_Homo sapiens_hsa05162	0.33975089
84	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.31609479
85	Pancreatic secretion_Homo sapiens_hsa04972	0.30751062
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28936701
87	Sulfur relay system_Homo sapiens_hsa04122	0.28406702
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.27277880
89	Prion diseases_Homo sapiens_hsa05020	0.26808241
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26763823
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.25542185
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24494941
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23306801
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.22799793
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.21646891
96	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.20381850
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.19665781
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.19246128
99	Viral carcinogenesis_Homo sapiens_hsa05203	0.16137798
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.15959963

TSPY2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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