TSPY26P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)4.79882975
2pyrimidine nucleobase catabolic process (GO:0006208)4.34937308
3behavioral response to nicotine (GO:0035095)4.28612317
4nonmotile primary cilium assembly (GO:0035058)3.83873823
5postsynaptic membrane organization (GO:0001941)3.82058362
6cornea development in camera-type eye (GO:0061303)3.76896282
7presynaptic membrane assembly (GO:0097105)3.74080733
8nucleobase catabolic process (GO:0046113)3.72531248
9L-fucose catabolic process (GO:0042355)3.54219780
10fucose catabolic process (GO:0019317)3.54219780
11L-fucose metabolic process (GO:0042354)3.54219780
12detection of light stimulus involved in sensory perception (GO:0050962)3.48820046
13detection of light stimulus involved in visual perception (GO:0050908)3.48820046
14presynaptic membrane organization (GO:0097090)3.48565409
15neuronal action potential propagation (GO:0019227)3.47313213
16otic vesicle formation (GO:0030916)3.42279811
17glycosphingolipid biosynthetic process (GO:0006688)3.42216750
18transmission of nerve impulse (GO:0019226)3.40805015
19negative regulation of translation, ncRNA-mediated (GO:0040033)3.33407165
20regulation of translation, ncRNA-mediated (GO:0045974)3.33407165
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33407165
22dendritic spine morphogenesis (GO:0060997)3.32949301
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.32553418
24central nervous system projection neuron axonogenesis (GO:0021952)3.32470263
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17609731
26cellular biogenic amine catabolic process (GO:0042402)3.15087614
27amine catabolic process (GO:0009310)3.15087614
28limb bud formation (GO:0060174)3.12698302
29response to pheromone (GO:0019236)3.11168664
30neuron recognition (GO:0008038)3.11032696
31kidney morphogenesis (GO:0060993)3.09700628
32sympathetic nervous system development (GO:0048485)3.07903774
33DNA deamination (GO:0045006)3.07172571
34axonal fasciculation (GO:0007413)3.06956770
35hindbrain development (GO:0030902)3.05398267
36head development (GO:0060322)3.05016260
37synaptic vesicle maturation (GO:0016188)3.04197561
38retinal ganglion cell axon guidance (GO:0031290)2.97006591
39negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96240254
40water-soluble vitamin biosynthetic process (GO:0042364)2.92764701
41negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91982090
42neuronal action potential (GO:0019228)2.89724554
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85602453
44regulation of telomere maintenance (GO:0032204)2.82409332
45cerebellar Purkinje cell differentiation (GO:0021702)2.80687178
46negative regulation of telomere maintenance (GO:0032205)2.80391737
47central nervous system neuron axonogenesis (GO:0021955)2.80138565
48regulation of action potential (GO:0098900)2.79378094
49indole-containing compound catabolic process (GO:0042436)2.79347144
50indolalkylamine catabolic process (GO:0046218)2.79347144
51tryptophan catabolic process (GO:0006569)2.79347144
52photoreceptor cell development (GO:0042461)2.78514801
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77355400
54seminiferous tubule development (GO:0072520)2.75914157
55C4-dicarboxylate transport (GO:0015740)2.74465202
56retina layer formation (GO:0010842)2.74346497
57mechanosensory behavior (GO:0007638)2.74097393
58cilium morphogenesis (GO:0060271)2.74095563
59protein polyglutamylation (GO:0018095)2.72406395
60protein localization to cilium (GO:0061512)2.72387821
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71750908
62regulation of cilium movement (GO:0003352)2.70588421
63neuron cell-cell adhesion (GO:0007158)2.68600362
64auditory behavior (GO:0031223)2.68376514
65startle response (GO:0001964)2.67940771
66somite development (GO:0061053)2.66333597
67cell migration in hindbrain (GO:0021535)2.64735345
68negative regulation of axonogenesis (GO:0050771)2.64183974
69adult walking behavior (GO:0007628)2.63408000
70membrane depolarization during action potential (GO:0086010)2.63229603
71olfactory bulb development (GO:0021772)2.62057564
72synaptic transmission, glutamatergic (GO:0035249)2.60009269
73indolalkylamine metabolic process (GO:0006586)2.59808531
74glutamate receptor signaling pathway (GO:0007215)2.59501022
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59391140
76axoneme assembly (GO:0035082)2.58157293
77atrial cardiac muscle cell action potential (GO:0086014)2.56928958
78regulation of gene silencing by RNA (GO:0060966)2.55927845
79regulation of posttranscriptional gene silencing (GO:0060147)2.55927845
80regulation of gene silencing by miRNA (GO:0060964)2.55927845
81cilium movement (GO:0003341)2.53648082
82eye photoreceptor cell development (GO:0042462)2.53133001
83vocalization behavior (GO:0071625)2.52566552
84protein localization to synapse (GO:0035418)2.52063971
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50300070
86regulation of neurotransmitter uptake (GO:0051580)2.49278246
87positive regulation of synapse assembly (GO:0051965)2.48840301
88photoreceptor cell maintenance (GO:0045494)2.48183314
89regulation of collateral sprouting (GO:0048670)2.47840842
90replication fork processing (GO:0031297)2.45353482
91epithelial cilium movement (GO:0003351)2.45021262
92cerebral cortex radially oriented cell migration (GO:0021799)2.43265658
93glycine transport (GO:0015816)2.42134635
94dopamine transport (GO:0015872)2.39966375
95protein-cofactor linkage (GO:0018065)2.39055715
96regulation of microtubule-based movement (GO:0060632)2.38871719
97neuromuscular synaptic transmission (GO:0007274)2.36843701
98spinal cord development (GO:0021510)2.35389002
99cilium organization (GO:0044782)2.33466026
100cell differentiation in hindbrain (GO:0021533)2.32696852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.98609036
2GBX2_23144817_ChIP-Seq_PC3_Human3.49257354
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98277161
4ZNF274_21170338_ChIP-Seq_K562_Hela2.92936982
5VDR_22108803_ChIP-Seq_LS180_Human2.90714860
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63057958
7IGF1R_20145208_ChIP-Seq_DFB_Human2.53877222
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43723518
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26656556
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.24181290
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23863657
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13154688
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.13154688
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08309084
15FUS_26573619_Chip-Seq_HEK293_Human2.07231771
16REST_21632747_ChIP-Seq_MESCs_Mouse2.01787013
17P300_19829295_ChIP-Seq_ESCs_Human2.01472516
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00375813
19TAF15_26573619_Chip-Seq_HEK293_Human1.88823046
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.87529324
21EWS_26573619_Chip-Seq_HEK293_Human1.84999292
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79911036
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77940136
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77774601
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77254040
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75270138
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.75116037
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72733443
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.67363479
30SMAD4_21799915_ChIP-Seq_A2780_Human1.64979412
31RNF2_27304074_Chip-Seq_NSC_Mouse1.64102194
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63197678
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62454813
34BCAT_22108803_ChIP-Seq_LS180_Human1.57627279
35STAT3_23295773_ChIP-Seq_U87_Human1.54323527
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.54287223
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51244967
38ER_23166858_ChIP-Seq_MCF-7_Human1.49754466
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49170415
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48648228
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47898706
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47280856
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46755111
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46407465
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.46019173
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45837157
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45672831
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.45057390
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44030713
50TCF4_23295773_ChIP-Seq_U87_Human1.44006451
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43498081
52AR_25329375_ChIP-Seq_VCAP_Human1.39983675
53CBP_20019798_ChIP-Seq_JUKART_Human1.39716744
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39716744
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38887579
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38320156
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34888596
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.34133528
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33515481
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.32795367
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30618987
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29419063
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.28695597
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28130205
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26048754
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25037784
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25037784
68RUNX2_22187159_ChIP-Seq_PCA_Human1.22904382
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22409844
70TP53_22573176_ChIP-Seq_HFKS_Human1.22304136
71DROSHA_22980978_ChIP-Seq_HELA_Human1.22262647
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20441360
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18896472
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18384501
75TCF4_22108803_ChIP-Seq_LS180_Human1.17965597
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15458133
77NANOG_19829295_ChIP-Seq_ESCs_Human1.15009669
78SOX2_19829295_ChIP-Seq_ESCs_Human1.15009669
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14390364
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13980197
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.13619220
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12986734
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12505515
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12154256
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.11960325
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11865487
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11822391
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07204806
89IRF1_19129219_ChIP-ChIP_H3396_Human1.07012067
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.06335784
91AR_21572438_ChIP-Seq_LNCaP_Human1.05427263
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05348086
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.04656305
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.03796835
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.03718594
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01734362
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.01661275
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01352623
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.99995749
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99441065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.32089375
2MP0004858_abnormal_nervous_system3.01175948
3MP0003880_abnormal_central_pattern2.90336678
4MP0005423_abnormal_somatic_nervous2.50888737
5MP0001968_abnormal_touch/_nociception2.48420476
6MP0003787_abnormal_imprinting2.45596161
7MP0003121_genomic_imprinting2.44704843
8MP0000569_abnormal_digit_pigmentation2.43351865
9MP0006276_abnormal_autonomic_nervous2.42531662
10MP0008877_abnormal_DNA_methylation2.39114329
11MP0001986_abnormal_taste_sensitivity2.36547039
12MP0004142_abnormal_muscle_tone2.35933130
13MP0006292_abnormal_olfactory_placode2.35231188
14MP0002736_abnormal_nociception_after2.28226871
15MP0004859_abnormal_synaptic_plasticity2.22231700
16MP0009046_muscle_twitch2.21165142
17MP0002653_abnormal_ependyma_morphology2.13804994
18MP0004885_abnormal_endolymph2.11144917
19MP0005551_abnormal_eye_electrophysiolog2.08485573
20MP0009745_abnormal_behavioral_response2.05322405
21MP0000778_abnormal_nervous_system2.01923242
22MP0002272_abnormal_nervous_system2.00884911
23MP0003635_abnormal_synaptic_transmissio1.95600048
24MP0001984_abnormal_olfaction1.75961715
25MP0002063_abnormal_learning/memory/cond1.69385396
26MP0001486_abnormal_startle_reflex1.67967196
27MP0002102_abnormal_ear_morphology1.66673930
28MP0002064_seizures1.66131986
29MP0008789_abnormal_olfactory_epithelium1.63548195
30MP0002572_abnormal_emotion/affect_behav1.63275537
31MP0002184_abnormal_innervation1.62401977
32MP0005645_abnormal_hypothalamus_physiol1.62145736
33MP0003195_calcinosis1.55875509
34MP0002638_abnormal_pupillary_reflex1.55839266
35MP0008872_abnormal_physiological_respon1.52928018
36MP0002734_abnormal_mechanical_nocicepti1.51896851
37MP0005174_abnormal_tail_pigmentation1.50455132
38MP0001188_hyperpigmentation1.50406836
39MP0001970_abnormal_pain_threshold1.48796864
40MP0001501_abnormal_sleep_pattern1.48017537
41MP0004270_analgesia1.47602906
42MP0004133_heterotaxia1.45059479
43MP0005646_abnormal_pituitary_gland1.44538732
44MP0002733_abnormal_thermal_nociception1.43724670
45MP0002735_abnormal_chemical_nociception1.43466606
46MP0002557_abnormal_social/conspecific_i1.37777151
47MP0002837_dystrophic_cardiac_calcinosis1.37598934
48MP0002938_white_spotting1.35799275
49MP0002876_abnormal_thyroid_physiology1.34767621
50MP0005394_taste/olfaction_phenotype1.33379987
51MP0005499_abnormal_olfactory_system1.33379987
52MP0006072_abnormal_retinal_apoptosis1.32774299
53MP0003136_yellow_coat_color1.32647274
54MP0000631_abnormal_neuroendocrine_gland1.31894291
55MP0000372_irregular_coat_pigmentation1.30673126
56MP0001529_abnormal_vocalization1.29755059
57MP0000955_abnormal_spinal_cord1.23094489
58MP0005386_behavior/neurological_phenoty1.22880942
59MP0004924_abnormal_behavior1.22880942
60MP0002067_abnormal_sensory_capabilities1.20748283
61MP0001502_abnormal_circadian_rhythm1.15379504
62MP0010386_abnormal_urinary_bladder1.14554032
63MP0005084_abnormal_gallbladder_morpholo1.13071562
64MP0002882_abnormal_neuron_morphology1.10781885
65MP0005253_abnormal_eye_physiology1.07901630
66MP0000427_abnormal_hair_cycle1.07725516
67MP0002752_abnormal_somatic_nervous1.07649099
68MP0002928_abnormal_bile_duct1.07393895
69MP0004043_abnormal_pH_regulation1.06568102
70MP0001440_abnormal_grooming_behavior1.06483063
71MP0002751_abnormal_autonomic_nervous1.06249098
72MP0001485_abnormal_pinna_reflex1.03299395
73MP0005075_abnormal_melanosome_morpholog1.00482572
74MP0008058_abnormal_DNA_repair0.98033000
75MP0004742_abnormal_vestibular_system0.97682622
76MP0002234_abnormal_pharynx_morphology0.95343149
77MP0002160_abnormal_reproductive_system0.93541303
78MP0001963_abnormal_hearing_physiology0.93266618
79MP0001293_anophthalmia0.91886406
80MP0003123_paternal_imprinting0.89720999
81MP0005195_abnormal_posterior_eye0.89500965
82MP0003119_abnormal_digestive_system0.89335248
83MP0000538_abnormal_urinary_bladder0.88436368
84MP0003890_abnormal_embryonic-extraembry0.87977755
85MP0003646_muscle_fatigue0.87158058
86MP0003283_abnormal_digestive_organ0.86691637
87MP0008875_abnormal_xenobiotic_pharmacok0.86362629
88MP0002233_abnormal_nose_morphology0.83894363
89MP0000516_abnormal_urinary_system0.82724723
90MP0005367_renal/urinary_system_phenotyp0.82724723
91MP0000015_abnormal_ear_pigmentation0.82074190
92MP0002066_abnormal_motor_capabilities/c0.81624862
93MP0002152_abnormal_brain_morphology0.80469633
94MP0000026_abnormal_inner_ear0.80253275
95MP0002163_abnormal_gland_morphology0.79475211
96MP0002277_abnormal_respiratory_mucosa0.76462537
97MP0001324_abnormal_eye_pigmentation0.75297094
98MP0003137_abnormal_impulse_conducting0.74317741
99MP0000049_abnormal_middle_ear0.73610360
100MP0003937_abnormal_limbs/digits/tail_de0.70981173

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.71101274
2Abnormality of the labia minora (HP:0012880)4.34479817
3Pancreatic fibrosis (HP:0100732)4.30494633
4True hermaphroditism (HP:0010459)4.24335270
5Abnormality of midbrain morphology (HP:0002418)4.12096196
6Molar tooth sign on MRI (HP:0002419)4.12096196
7Failure to thrive in infancy (HP:0001531)3.86834769
8Congenital stationary night blindness (HP:0007642)3.80148733
9Nephronophthisis (HP:0000090)3.63043670
10Gait imbalance (HP:0002141)3.21214753
11Medial flaring of the eyebrow (HP:0010747)3.16768299
12Abnormality of the renal medulla (HP:0100957)3.15158539
13Febrile seizures (HP:0002373)3.13153228
14Hyperventilation (HP:0002883)3.06286570
15Cystic liver disease (HP:0006706)3.05505531
16Polyphagia (HP:0002591)3.04546348
17Pendular nystagmus (HP:0012043)2.99998763
18Chronic hepatic failure (HP:0100626)2.85241865
19Congenital primary aphakia (HP:0007707)2.82589232
20Attenuation of retinal blood vessels (HP:0007843)2.81972828
21Abnormality of the renal cortex (HP:0011035)2.79405897
22Focal motor seizures (HP:0011153)2.77834737
23Abnormal rod and cone electroretinograms (HP:0008323)2.77485300
24Abnormal hair whorl (HP:0010721)2.77204185
25Broad-based gait (HP:0002136)2.69978804
26Sclerocornea (HP:0000647)2.60703351
27Oligodactyly (hands) (HP:0001180)2.60204293
28Absent speech (HP:0001344)2.60049443
29Nephrogenic diabetes insipidus (HP:0009806)2.55336185
30Anencephaly (HP:0002323)2.54634576
31Hip dysplasia (HP:0001385)2.49654966
32Genital tract atresia (HP:0001827)2.49507174
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.45661033
34Vaginal atresia (HP:0000148)2.45190070
35Type II lissencephaly (HP:0007260)2.41686141
36Focal seizures (HP:0007359)2.40216623
37Atonic seizures (HP:0010819)2.40112369
38Progressive cerebellar ataxia (HP:0002073)2.36755328
39Epileptic encephalopathy (HP:0200134)2.36617674
40Abnormal ciliary motility (HP:0012262)2.28423937
41Renal cortical cysts (HP:0000803)2.27234293
42Poor coordination (HP:0002370)2.26967246
43Decreased central vision (HP:0007663)2.25926348
44Increased corneal curvature (HP:0100692)2.23696994
45Keratoconus (HP:0000563)2.23696994
46Abnormal drinking behavior (HP:0030082)2.21960752
47Polydipsia (HP:0001959)2.21960752
48Dialeptic seizures (HP:0011146)2.21650193
49Bony spicule pigmentary retinopathy (HP:0007737)2.21179462
50Protruding tongue (HP:0010808)2.17813856
51Poor suck (HP:0002033)2.17426143
52Drooling (HP:0002307)2.15480075
53Lissencephaly (HP:0001339)2.14617930
54Intestinal atresia (HP:0011100)2.13475402
55Genetic anticipation (HP:0003743)2.12186495
56Abolished electroretinogram (ERG) (HP:0000550)2.11673190
57Specific learning disability (HP:0001328)2.11605940
58Gaze-evoked nystagmus (HP:0000640)2.09597769
59Inability to walk (HP:0002540)2.08682337
60Narrow forehead (HP:0000341)2.07389219
61Pachygyria (HP:0001302)2.04754637
62Congenital hepatic fibrosis (HP:0002612)2.04596677
63Absence seizures (HP:0002121)2.03747502
64Postaxial foot polydactyly (HP:0001830)2.02503422
65Fair hair (HP:0002286)2.02461931
66Optic nerve hypoplasia (HP:0000609)2.01156925
67Narrow nasal bridge (HP:0000446)2.00625685
68Severe visual impairment (HP:0001141)1.98351529
69Labial hypoplasia (HP:0000066)1.97066769
70Dyskinesia (HP:0100660)1.96951708
71Excessive salivation (HP:0003781)1.92212852
72Absent/shortened dynein arms (HP:0200106)1.90571694
73Dynein arm defect of respiratory motile cilia (HP:0012255)1.90571694
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.89798225
75Chorioretinal atrophy (HP:0000533)1.88920874
76Abnormal respiratory motile cilium physiology (HP:0012261)1.87474048
77Male pseudohermaphroditism (HP:0000037)1.85814858
78Tubular atrophy (HP:0000092)1.85403703
79Myokymia (HP:0002411)1.84969326
80Furrowed tongue (HP:0000221)1.83758681
81Dandy-Walker malformation (HP:0001305)1.83364586
82Hemiparesis (HP:0001269)1.82978084
83Preaxial hand polydactyly (HP:0001177)1.82963385
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82566371
85Hypoplastic female external genitalia (HP:0012815)1.82015286
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81568004
87Postaxial hand polydactyly (HP:0001162)1.80295619
88Polyuria (HP:0000103)1.78399668
89Limb dystonia (HP:0002451)1.78362431
90Oligomenorrhea (HP:0000876)1.76859617
91Aqueductal stenosis (HP:0002410)1.76242552
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.74358627
93Hypoplasia of the fovea (HP:0007750)1.74358627
94Short foot (HP:0001773)1.73605043
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70510446
96Megalencephaly (HP:0001355)1.70071798
97Anophthalmia (HP:0000528)1.69217478
98Scrotal hypoplasia (HP:0000046)1.68803233
99Sleep apnea (HP:0010535)1.67417187
100Status epilepticus (HP:0002133)1.67271916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.29667905
2CASK3.50608284
3MARK13.29833039
4MAPK133.12124249
5PINK12.50554396
6BMPR1B2.48506697
7WNK32.38276828
8MAP4K22.29490939
9TNIK2.10450880
10ADRBK22.09166982
11GRK12.05734006
12NUAK11.90384573
13DYRK21.86584530
14WNK41.76542303
15OXSR11.68660975
16NTRK31.63800639
17MAP3K41.58647319
18CDK191.58444161
19INSRR1.56062638
20TRIM281.46270120
21PRKD31.45926666
22MKNK21.41131085
23CAMKK21.39386237
24CAMK11.37602045
25PLK21.35465368
26PRKCG1.34840976
27STK391.31170772
28PAK31.30233017
29EPHA41.25646043
30PHKG11.19629431
31PHKG21.19629431
32NTRK21.18188556
33ACVR1B1.14578156
34DAPK21.12561702
35ZAK1.12338942
36CAMK1G1.09451862
37PNCK1.05659629
38FGFR21.01390461
39TAOK31.00361307
40CSNK1G20.99596613
41ADRBK10.97012737
42CAMK1D0.95556670
43TIE10.94166683
44PRKCE0.92575185
45MAPK150.88529905
46PKN10.84497709
47CSNK1G10.82596271
48CSNK1G30.82548474
49STK38L0.82408575
50DYRK1A0.80735151
51TXK0.80327032
52CCNB10.78754654
53STK110.74504302
54VRK10.72750314
55MUSK0.72505723
56NEK20.70068854
57PRKCZ0.69460055
58SGK20.67931959
59MKNK10.67833361
60CDK50.64600317
61BCR0.63135364
62MAP2K70.62937723
63BRD40.60038672
64CSNK1D0.58528900
65CAMK2A0.58328756
66TLK10.56608481
67GRK50.56396445
68LMTK20.55998222
69CSNK1A1L0.55159840
70PRKCQ0.54427598
71PTK2B0.54414766
72CSNK1A10.53684649
73BRSK20.52917022
74SGK2230.52186567
75SGK4940.52186567
76TGFBR10.50805699
77PRKCI0.50068998
78MAPKAPK50.49282707
79GRK70.47445702
80TEC0.46943979
81TNK20.46632057
82PLK30.46415652
83MINK10.45922273
84PRKACA0.44983997
85NME10.44465685
86TAF10.43699592
87PRKG10.43683038
88ERBB30.43432557
89CAMK40.42312011
90DMPK0.42277112
91PRKAA10.42146583
92PRKCH0.41871253
93EIF2AK30.41770331
94WEE10.40598806
95EIF2AK20.40217076
96RPS6KA20.39646303
97MAP2K20.38935521
98BRAF0.37492178
99TYRO30.35451466
100PLK40.34298212

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29454131
2Phototransduction_Homo sapiens_hsa047442.92194111
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.80797056
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12105716
5Morphine addiction_Homo sapiens_hsa050322.07673038
6Butanoate metabolism_Homo sapiens_hsa006502.07326493
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03739499
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03400573
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02649638
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02183618
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98158859
12Linoleic acid metabolism_Homo sapiens_hsa005911.98062298
13Nitrogen metabolism_Homo sapiens_hsa009101.95572667
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89058765
15GABAergic synapse_Homo sapiens_hsa047271.85548318
16Fanconi anemia pathway_Homo sapiens_hsa034601.84842865
17Glutamatergic synapse_Homo sapiens_hsa047241.77163340
18Insulin secretion_Homo sapiens_hsa049111.72575805
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.70734485
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.70683008
21Taste transduction_Homo sapiens_hsa047421.70434923
22Circadian entrainment_Homo sapiens_hsa047131.66355160
23RNA polymerase_Homo sapiens_hsa030201.59293621
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56921287
25Ether lipid metabolism_Homo sapiens_hsa005651.54640473
26Dorso-ventral axis formation_Homo sapiens_hsa043201.54000186
27Homologous recombination_Homo sapiens_hsa034401.47368630
28Steroid biosynthesis_Homo sapiens_hsa001001.46564259
29Olfactory transduction_Homo sapiens_hsa047401.45677382
30Basal transcription factors_Homo sapiens_hsa030221.41336092
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40960637
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40279199
33Serotonergic synapse_Homo sapiens_hsa047261.34052844
34Synaptic vesicle cycle_Homo sapiens_hsa047211.33358424
35Selenocompound metabolism_Homo sapiens_hsa004501.31438987
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24893459
37Dopaminergic synapse_Homo sapiens_hsa047281.23872202
38Oxidative phosphorylation_Homo sapiens_hsa001901.19997423
39Tryptophan metabolism_Homo sapiens_hsa003801.18579427
40Axon guidance_Homo sapiens_hsa043601.18036982
41Caffeine metabolism_Homo sapiens_hsa002321.14407487
42Calcium signaling pathway_Homo sapiens_hsa040201.12687337
43Amphetamine addiction_Homo sapiens_hsa050311.08814978
44Long-term depression_Homo sapiens_hsa047301.08771734
45Hedgehog signaling pathway_Homo sapiens_hsa043401.08409225
46Salivary secretion_Homo sapiens_hsa049701.04952939
47Cardiac muscle contraction_Homo sapiens_hsa042601.02688279
48Cholinergic synapse_Homo sapiens_hsa047251.01333723
49Collecting duct acid secretion_Homo sapiens_hsa049660.97590350
50RNA degradation_Homo sapiens_hsa030180.96468585
51Cocaine addiction_Homo sapiens_hsa050300.94693594
52Parkinsons disease_Homo sapiens_hsa050120.94592708
53Protein export_Homo sapiens_hsa030600.94560091
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93143631
55Oxytocin signaling pathway_Homo sapiens_hsa049210.92367233
56Regulation of autophagy_Homo sapiens_hsa041400.88000224
57Ovarian steroidogenesis_Homo sapiens_hsa049130.87912160
58cAMP signaling pathway_Homo sapiens_hsa040240.86609518
59Propanoate metabolism_Homo sapiens_hsa006400.85000239
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.83024188
61Basal cell carcinoma_Homo sapiens_hsa052170.82405236
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79414265
63Retinol metabolism_Homo sapiens_hsa008300.72887433
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71733879
65ABC transporters_Homo sapiens_hsa020100.71524618
66Renin secretion_Homo sapiens_hsa049240.70847879
67Pancreatic secretion_Homo sapiens_hsa049720.70065780
68Peroxisome_Homo sapiens_hsa041460.69617416
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.69497940
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.68020167
71Gastric acid secretion_Homo sapiens_hsa049710.65460501
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61696905
73Chemical carcinogenesis_Homo sapiens_hsa052040.59557258
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58481233
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57267854
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56850191
77Alzheimers disease_Homo sapiens_hsa050100.56511957
78Arachidonic acid metabolism_Homo sapiens_hsa005900.54898711
79Purine metabolism_Homo sapiens_hsa002300.54550129
80One carbon pool by folate_Homo sapiens_hsa006700.54457625
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54456488
82Huntingtons disease_Homo sapiens_hsa050160.52879397
83Non-homologous end-joining_Homo sapiens_hsa034500.50947919
84Mineral absorption_Homo sapiens_hsa049780.48504901
85Long-term potentiation_Homo sapiens_hsa047200.48503924
86beta-Alanine metabolism_Homo sapiens_hsa004100.47149722
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45892079
88Vitamin digestion and absorption_Homo sapiens_hsa049770.41820659
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40332935
90Melanogenesis_Homo sapiens_hsa049160.40257327
91Circadian rhythm_Homo sapiens_hsa047100.37279529
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36330720
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33811903
94Hippo signaling pathway_Homo sapiens_hsa043900.33794853
95Wnt signaling pathway_Homo sapiens_hsa043100.33767161
96Metabolic pathways_Homo sapiens_hsa011000.31554551
97Pyrimidine metabolism_Homo sapiens_hsa002400.31154130
98Alcoholism_Homo sapiens_hsa050340.30518437
99Glycerolipid metabolism_Homo sapiens_hsa005610.29690021
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29569365

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