TSPY4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mesoderm development (GO:0007498)8.06136207
2* mesenchyme development (GO:0060485)7.39330328
3* gonadal mesoderm development (GO:0007506)60.2193937
4sex differentiation (GO:0007548)6.51751897
5N-acetylneuraminate metabolic process (GO:0006054)5.89755857
6* nucleosome assembly (GO:0006334)4.90558465
7* protein-DNA complex assembly (GO:0065004)4.21089199
8* nucleosome organization (GO:0034728)4.00992330
9* protein-DNA complex subunit organization (GO:0071824)3.54659333
10ribosomal small subunit biogenesis (GO:0042274)3.27917220
11regulation of activation of Janus kinase activity (GO:0010533)3.02109677
12interleukin-6-mediated signaling pathway (GO:0070102)2.97782443
13ribosomal small subunit assembly (GO:0000028)2.89747460
14mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.78751789
15positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.78751789
16piRNA metabolic process (GO:0034587)2.53419617
17apoptotic cell clearance (GO:0043277)2.53003123
18mitotic chromosome condensation (GO:0007076)2.46342086
19regulation of isotype switching to IgG isotypes (GO:0048302)2.31303259
20sialylation (GO:0097503)2.25996547
21protein K63-linked deubiquitination (GO:0070536)2.22685910
22regulation of meiosis I (GO:0060631)2.19294085
23protein K48-linked deubiquitination (GO:0071108)2.17141772
24positive regulation of viral genome replication (GO:0045070)2.15821895
25formation of translation preinitiation complex (GO:0001731)2.08640251
26positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.03781434
27viral transcription (GO:0019083)2.01997082
28mitotic sister chromatid cohesion (GO:0007064)1.99981036
29translational termination (GO:0006415)1.98636867
30COPI coating of Golgi vesicle (GO:0048205)1.95347213
31Golgi transport vesicle coating (GO:0048200)1.95347213
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)1.94700013
33protein localization to endoplasmic reticulum (GO:0070972)1.92029503
34cotranslational protein targeting to membrane (GO:0006613)1.89978537
35protein targeting to ER (GO:0045047)1.88278361
36translational elongation (GO:0006414)1.87200852
37negative regulation of Notch signaling pathway (GO:0045746)1.86853122
38* spermatogenesis (GO:0007283)1.83998365
39* male gamete generation (GO:0048232)1.83899531
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.82733246
41establishment of protein localization to endoplasmic reticulum (GO:0072599)1.81016781
42cellular response to interleukin-6 (GO:0071354)1.79581423
43amyloid precursor protein catabolic process (GO:0042987)1.78401790
44positive regulation of alpha-beta T cell proliferation (GO:0046641)1.74926859
45positive regulation of mitochondrial membrane permeability (GO:0035794)1.73327382
46amyloid precursor protein metabolic process (GO:0042982)1.72490822
47ribonucleoprotein complex biogenesis (GO:0022613)1.72476067
48cellular sodium ion homeostasis (GO:0006883)1.70101916
49positive regulation of translational initiation (GO:0045948)1.69866053
50mitotic metaphase plate congression (GO:0007080)1.69322783
51male meiosis (GO:0007140)1.68534862
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)1.68227253
53viral life cycle (GO:0019058)1.67906255
54* gamete generation (GO:0007276)1.66392959
55regulation of translational fidelity (GO:0006450)1.66233700
56protein N-linked glycosylation via asparagine (GO:0018279)1.64313603
57establishment of integrated proviral latency (GO:0075713)1.64259814
58ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)1.64117180
59* reproductive structure development (GO:0048608)1.62656805
60peptidyl-asparagine modification (GO:0018196)1.62484435
61ganglioside metabolic process (GO:0001573)1.62125394
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)1.61946941
63translational initiation (GO:0006413)1.61332134
64nucleotide transmembrane transport (GO:1901679)1.58756016
65neutrophil mediated immunity (GO:0002446)1.57615303
66ER overload response (GO:0006983)1.55479855
67regulation of chromatin binding (GO:0035561)1.54505511
68ribosome biogenesis (GO:0042254)1.53521974
69protein N-linked glycosylation (GO:0006487)1.52216816
70cellular protein complex disassembly (GO:0043624)1.52005540
71regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.51818101
72chaperone mediated protein folding requiring cofactor (GO:0051085)1.50698162
73COPII vesicle coating (GO:0048208)1.49670815
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.49520288
75nucleotide transport (GO:0006862)1.49200635
76sodium ion homeostasis (GO:0055078)1.48409253
77meiotic chromosome segregation (GO:0045132)1.48051450
78ncRNA 3-end processing (GO:0043628)1.47748926
79DNA strand elongation involved in DNA replication (GO:0006271)1.47045602
80proline biosynthetic process (GO:0006561)1.46987664
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)1.46598629
82DNA strand elongation (GO:0022616)1.46010143
83protein targeting to membrane (GO:0006612)1.45326352
84amino sugar metabolic process (GO:0006040)1.44500202
85N-terminal protein amino acid acetylation (GO:0006474)1.44172688
86telomere maintenance via semi-conservative replication (GO:0032201)1.44163627
87regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)1.42622780
88somatic hypermutation of immunoglobulin genes (GO:0016446)1.42580558
89somatic diversification of immune receptors via somatic mutation (GO:0002566)1.42580558
90response to interleukin-6 (GO:0070741)1.41507060
91regulation of penile erection (GO:0060405)1.40526778
92negative regulation of meiosis (GO:0045835)1.40253922
93deoxyribonucleotide biosynthetic process (GO:0009263)1.40061750
94DNA replication initiation (GO:0006270)1.39556085
95complement activation, classical pathway (GO:0006958)1.39343390
96protein K6-linked ubiquitination (GO:0085020)1.39301443
97autophagic vacuole fusion (GO:0000046)1.39295681
98negative regulation of interleukin-8 production (GO:0032717)1.37325116
99viral protein processing (GO:0019082)1.37000462
100mitotic nuclear envelope disassembly (GO:0007077)1.35998915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57467065
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.99201497
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95930056
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71114798
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.60691766
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.22479103
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21340079
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01231716
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89881425
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84076396
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77150429
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.75286873
13TFEB_21752829_ChIP-Seq_HELA_Human2.74396306
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.65272118
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56163551
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.55893110
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52564767
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49935666
19DCP1A_22483619_ChIP-Seq_HELA_Human2.44330904
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34826414
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32244462
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19359576
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18468971
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.17427792
25GABP_19822575_ChIP-Seq_HepG2_Human2.16726030
26ZFX_18555785_ChIP-Seq_MESCs_Mouse2.15835698
27TTF2_22483619_ChIP-Seq_HELA_Human2.10250036
28MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01323032
29VDR_23849224_ChIP-Seq_CD4+_Human2.01311537
30FOXP3_21729870_ChIP-Seq_TREG_Human2.00108108
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.97398669
32XRN2_22483619_ChIP-Seq_HELA_Human1.96639836
33MYC_22102868_ChIP-Seq_BL_Human1.95197376
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93209231
35CIITA_25753668_ChIP-Seq_RAJI_Human1.89954271
36SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.85841414
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83614645
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83464413
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81205004
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78529230
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.77783817
42KDM5A_27292631_Chip-Seq_BREAST_Human1.73392613
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69615742
44CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.68436169
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.65968959
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63862224
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60298953
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58342359
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57776711
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57042038
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52333672
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50672823
53ELK1_19687146_ChIP-ChIP_HELA_Human1.50332619
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49666684
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48989472
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47504163
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46700277
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46464613
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44363737
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43336776
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42752153
62IGF1R_20145208_ChIP-Seq_DFB_Human1.41226720
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37931333
64SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.34124740
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33892494
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30837344
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30378413
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.28533248
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24483180
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19730578
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15285575
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14578962
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13930752
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.11025317
75TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10012241
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08539479
77AR_21909140_ChIP-Seq_LNCAP_Human1.08327102
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04148855
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03978338
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00891987
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99173274
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97461897
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92728281
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91014115
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87188161
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87117919
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.86622264
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86574216
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84900111
90MYB_26560356_Chip-Seq_TH2_Human0.81731988
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81138222
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80888093
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80738725
94BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79744493
95SCL_19346495_ChIP-Seq_HPC-7_Human0.78156178
96NCOR1_26117541_ChIP-Seq_K562_Human0.77620383
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76895779
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76798130
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76483762
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76322702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation8.26669787
2MP0003136_yellow_coat_color5.59071078
3MP0003693_abnormal_embryo_hatching3.97507809
4MP0005171_absent_coat_pigmentation3.76862419
5MP0005058_abnormal_lysosome_morphology3.69826736
6MP0009333_abnormal_splenocyte_physiolog2.98671652
7MP0004957_abnormal_blastocyst_morpholog2.68955678
8MP0003111_abnormal_nucleus_morphology2.58975671
9MP0005174_abnormal_tail_pigmentation2.52775626
10MP0009840_abnormal_foam_cell2.41047900
11MP0008057_abnormal_DNA_replication2.30524413
12MP0001348_abnormal_lacrimal_gland2.19371910
13MP0008058_abnormal_DNA_repair2.11494092
14MP0003077_abnormal_cell_cycle2.05516957
15MP0005451_abnormal_body_composition2.03674541
16MP0008995_early_reproductive_senescence1.92093064
17MP0003183_abnormal_peptide_metabolism1.78767033
18MP0010307_abnormal_tumor_latency1.77599934
19MP0002210_abnormal_sex_determination1.71461455
20MP0003172_abnormal_lysosome_physiology1.67036486
21MP0010368_abnormal_lymphatic_system1.65140051
22MP0004043_abnormal_pH_regulation1.63888347
23MP0008932_abnormal_embryonic_tissue1.63722777
24MP0002168_other_aberrant_phenotype1.59443321
25MP0001145_abnormal_male_reproductive1.55198619
26MP0001929_abnormal_gametogenesis1.53944214
27MP0001730_embryonic_growth_arrest1.52788734
28MP0000350_abnormal_cell_proliferation1.45774734
29MP0003786_premature_aging1.42427578
30MP0000747_muscle_weakness1.42048500
31MP0010094_abnormal_chromosome_stability1.40876613
32MP0005395_other_phenotype1.34156529
33MP0001663_abnormal_digestive_system1.31536071
34MP0001188_hyperpigmentation1.29863334
35MP0005408_hypopigmentation1.28822807
36MP0000653_abnormal_sex_gland1.27200191
37MP0005220_abnormal_exocrine_pancreas1.25947106
38MP0003698_abnormal_male_reproductive1.25776885
39MP0005671_abnormal_response_to1.22264175
40MP0003763_abnormal_thymus_physiology1.13927833
41MP0004147_increased_porphyrin_level1.13217777
42MP0002090_abnormal_vision1.06643228
43MP0002080_prenatal_lethality1.06553077
44MP0000313_abnormal_cell_death1.05669221
45MP0001661_extended_life_span1.05175110
46MP0005381_digestive/alimentary_phenotyp1.04545072
47MP0005670_abnormal_white_adipose1.04404910
48MP0000358_abnormal_cell_content/1.04115501
49MP0000372_irregular_coat_pigmentation1.03311276
50MP0002075_abnormal_coat/hair_pigmentati1.03185345
51MP0008007_abnormal_cellular_replicative1.00700536
52MP0010234_abnormal_vibrissa_follicle1.00035327
53MP0003959_abnormal_lean_body0.96211540
54MP0001697_abnormal_embryo_size0.95744924
55MP0002095_abnormal_skin_pigmentation0.95730940
56MP0005075_abnormal_melanosome_morpholog0.94644138
57MP0003186_abnormal_redox_activity0.92855241
58MP0003718_maternal_effect0.91865303
59MP0001186_pigmentation_phenotype0.91532581
60MP0008569_lethality_at_weaning0.91499256
61MP0001324_abnormal_eye_pigmentation0.87680957
62MP0003656_abnormal_erythrocyte_physiolo0.87165160
63MP0006035_abnormal_mitochondrial_morpho0.86831418
64MP0002796_impaired_skin_barrier0.86754971
65MP0009672_abnormal_birth_weight0.86440702
66MP0004233_abnormal_muscle_weight0.86363921
67MP0000689_abnormal_spleen_morphology0.84304853
68MP0004808_abnormal_hematopoietic_stem0.83571304
69MP0005464_abnormal_platelet_physiology0.79905620
70MP0002398_abnormal_bone_marrow0.77091880
71MP0008260_abnormal_autophagy0.75028678
72MP0002161_abnormal_fertility/fecundity0.74675557
73MP0005384_cellular_phenotype0.73470577
74MP0001542_abnormal_bone_strength0.73299794
75MP0002429_abnormal_blood_cell0.71852593
76MP0002163_abnormal_gland_morphology0.71531349
77MP0000703_abnormal_thymus_morphology0.71105670
78MP0003943_abnormal_hepatobiliary_system0.69797741
79MP0001919_abnormal_reproductive_system0.68851738
80MP0000685_abnormal_immune_system0.68408372
81MP0005621_abnormal_cell_physiology0.67286948
82MP0002396_abnormal_hematopoietic_system0.65983326
83MP0002751_abnormal_autonomic_nervous0.65312594
84MP0003221_abnormal_cardiomyocyte_apopto0.64964948
85MP0000716_abnormal_immune_system0.63307483
86MP0002084_abnormal_developmental_patter0.62487190
87MP0001666_abnormal_nutrient_absorption0.62193864
88MP0005379_endocrine/exocrine_gland_phen0.61523941
89MP0001270_distended_abdomen0.60484921
90MP0002877_abnormal_melanocyte_morpholog0.60364813
91MP0004197_abnormal_fetal_growth/weight/0.60333689
92MP0002019_abnormal_tumor_incidence0.60104441
93MP0000598_abnormal_liver_morphology0.59931119
94MP0000490_abnormal_crypts_of0.59465023
95MP0003868_abnormal_feces_composition0.58752974
96MP0002229_neurodegeneration0.56292744
97MP0009643_abnormal_urine_homeostasis0.55930240
98MP0009785_altered_susceptibility_to0.54062153
99MP0008877_abnormal_DNA_methylation0.54049751
100MP0005389_reproductive_system_phenotype0.53714443

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)4.77436941
2Increased cerebral lipofuscin (HP:0011813)4.62601514
3Vacuolated lymphocytes (HP:0001922)4.26694152
4Carpal bone hypoplasia (HP:0001498)3.95492126
5Aplasia/Hypoplasia of the sacrum (HP:0008517)3.94277751
6Patchy hypopigmentation of hair (HP:0011365)3.92590605
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.78855301
8Abnormality of liposaccharide metabolism (HP:0010968)3.77763097
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.77763097
10Abnormality of glycolipid metabolism (HP:0010969)3.77763097
11Albinism (HP:0001022)3.58075566
12Decreased circulating renin level (HP:0003351)3.46020230
13White forelock (HP:0002211)3.39020372
14Hyperactive renin-angiotensin system (HP:0000841)3.34728448
15Vertebral compression fractures (HP:0002953)3.34302917
16Reticulocytopenia (HP:0001896)3.33535117
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31458770
18Large for gestational age (HP:0001520)3.30525977
19Abnormal auditory evoked potentials (HP:0006958)3.23451118
20Short middle phalanx of the 5th finger (HP:0004220)3.19861769
21Upper limb muscle weakness (HP:0003484)3.06247306
22Dysostosis multiplex (HP:0000943)3.06019700
23Overlapping toe (HP:0001845)3.05460784
24Abnormal number of erythroid precursors (HP:0012131)3.03720707
25Back pain (HP:0003418)2.98984653
26Spastic paraparesis (HP:0002313)2.80519802
27Basal cell carcinoma (HP:0002671)2.80463603
28Tetraparesis (HP:0002273)2.80022025
29Abnormality of cells of the erythroid lineage (HP:0012130)2.79714090
30Abnormality of the distal phalanges of the toes (HP:0010182)2.79579384
31Hypoplasia of the uterus (HP:0000013)2.78957734
32Ankyloglossia (HP:0010296)2.75076752
33Abnormal tarsal ossification (HP:0008369)2.67030899
34Cutaneous melanoma (HP:0012056)2.62773258
35Small epiphyses (HP:0010585)2.54541353
36Nonimmune hydrops fetalis (HP:0001790)2.49297889
37Microretrognathia (HP:0000308)2.47972187
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.46783998
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46783998
40Abnormal protein glycosylation (HP:0012346)2.45954798
41Abnormal glycosylation (HP:0012345)2.45954798
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45954798
43Abnormal protein N-linked glycosylation (HP:0012347)2.45954798
44Deep palmar crease (HP:0006191)2.41256036
45Hypercortisolism (HP:0001578)2.40544586
46Syringomyelia (HP:0003396)2.39659804
47Spinal cord lesions (HP:0100561)2.39659804
48Abnormality of incisor morphology (HP:0011063)2.38702437
49Hyperlipoproteinemia (HP:0010980)2.38692289
50Long palpebral fissure (HP:0000637)2.37306438
51Exocrine pancreatic insufficiency (HP:0001738)2.36927771
52Thoracolumbar scoliosis (HP:0002944)2.34391511
53Squamous cell carcinoma (HP:0002860)2.33980472
54Dry hair (HP:0011359)2.33381298
55Acute hepatic failure (HP:0006554)2.29539334
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28754362
57Urethral obstruction (HP:0000796)2.28042357
58Abnormality of the lumbar spine (HP:0100712)2.25116222
59CNS hypomyelination (HP:0003429)2.22743037
60Ridged nail (HP:0001807)2.20325301
61Onycholysis (HP:0001806)2.20089594
62Abnormality of oral frenula (HP:0000190)2.17565697
63Hypokalemic alkalosis (HP:0001949)2.16259240
64Hyponatremia (HP:0002902)2.11401585
65Chronic bronchitis (HP:0004469)2.10929664
66Unilateral renal agenesis (HP:0000122)2.08918689
67Hyperkalemia (HP:0002153)2.08619884
68Cortical dysplasia (HP:0002539)2.08282135
69Type I transferrin isoform profile (HP:0003642)2.07692974
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.03654530
71Aplasia/hypoplasia of the uterus (HP:0008684)2.03505184
72Visual hallucinations (HP:0002367)2.03331667
73Deformed sella turcica (HP:0002681)2.03127590
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00799988
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00799988
76Global brain atrophy (HP:0002283)1.99212224
77Recurrent cutaneous fungal infections (HP:0011370)1.97706034
78Chronic mucocutaneous candidiasis (HP:0002728)1.97706034
79Gonadal dysgenesis (HP:0000133)1.95997345
80Hypopigmentation of the fundus (HP:0007894)1.95952504
81Erythema (HP:0010783)1.94478529
82Chromsome breakage (HP:0040012)1.93009211
83J-shaped sella turcica (HP:0002680)1.92806841
84Reduced antithrombin III activity (HP:0001976)1.92233439
85Lower limb hyperreflexia (HP:0002395)1.91630364
86Abnormal foot bone ossification (HP:0010675)1.91417913
87Hypokinesia (HP:0002375)1.90904917
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.88096715
89Abnormality of the thoracic spine (HP:0100711)1.85655377
90Premature skin wrinkling (HP:0100678)1.84617898
91Autoimmune hemolytic anemia (HP:0001890)1.84022072
92Macrocytic anemia (HP:0001972)1.83254588
93Abnormality of the corticospinal tract (HP:0002492)1.83032192
94Thoracic kyphosis (HP:0002942)1.82472834
95Death in infancy (HP:0001522)1.82466630
96Premature graying of hair (HP:0002216)1.81864336
97Conical tooth (HP:0000698)1.80923926
98Adrenal overactivity (HP:0002717)1.79243866
99Self-mutilation (HP:0000742)1.79026368
100Pallor (HP:0000980)1.78995716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B6.23349781
2EIF2AK34.46770471
3CDK193.59550254
4KSR23.43439313
5ARAF3.21249456
6TAOK23.06179726
7BRAF2.97905064
8TAF12.84107075
9MAP3K92.81855450
10CDC72.67365389
11ERN12.60136550
12NME22.58027292
13IRAK32.50475294
14SCYL22.36940756
15ITK2.12168112
16ACVR1B2.01797599
17MAP3K131.99998710
18STK161.86672574
19RAF11.76817502
20TTK1.62827997
21KSR11.58473962
22CDK31.53237515
23EEF2K1.48038931
24TESK21.47872678
25CDK81.43523476
26BRSK11.26527302
27MAPK71.25357366
28PBK1.23711417
29MAP3K81.19733183
30BUB11.15920456
31WEE11.10254226
32MAP3K11.02677831
33ICK1.02526976
34MOS0.97292369
35MAP3K20.94497654
36PLK40.90707293
37IRAK40.87389175
38CDK70.85343165
39MARK30.84517030
40MAP3K100.83617789
41IRAK20.83346042
42LRRK20.80972312
43STK100.80429934
44AKT20.77062245
45RPS6KB10.77050184
46NME10.75450545
47JAK20.69709788
48CHEK10.68172530
49BMPR1B0.64161245
50RPS6KB20.62576580
51PLK10.61834858
52AURKA0.59436277
53SRPK10.59240545
54MAP3K140.57794578
55CDK11A0.56012019
56PIM10.55698249
57MAPK120.55005335
58CSNK2A10.54752785
59PAK20.54665258
60GRK60.51151370
61MARK20.49164841
62CDK140.45957363
63ATR0.45870890
64PAK10.42675258
65CHEK20.41771593
66PRKCI0.41738690
67PDPK10.41398999
68MATK0.41222131
69TBK10.40805585
70MST40.40390179
71ALK0.40269439
72MAP2K20.38356660
73DYRK1B0.37919975
74RPS6KL10.37601503
75RPS6KC10.37601503
76CDK150.36865669
77AURKB0.36092765
78STK240.35068240
79SIK10.34733957
80NEK10.34678402
81TAOK30.32536383
82IRAK10.32043044
83CDK20.31879053
84CDK180.31291908
85MUSK0.30868948
86AKT30.30783724
87PDK10.30577922
88RPS6KA60.29440444
89PLK30.29153570
90CDK10.28664293
91ATM0.28374952
92CCNB10.26839175
93BCKDK0.26438091
94CSF1R0.26017295
95CDK120.25417950
96TSSK60.23572886
97CSNK2A20.23572056
98TYK20.22300766
99PNCK0.22186519
100JAK10.21100532

Predicted pathways (KEGG)

RankGene SetZ-score
1N-Glycan biosynthesis_Homo sapiens_hsa005104.78356703
2DNA replication_Homo sapiens_hsa030303.63600585
3Ribosome_Homo sapiens_hsa030103.39844758
4Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.15898028
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.98577964
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75639101
7Mismatch repair_Homo sapiens_hsa034302.60909211
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.59928125
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34804450
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.17130588
11One carbon pool by folate_Homo sapiens_hsa006702.12833628
12Dorso-ventral axis formation_Homo sapiens_hsa043202.12191717
13Base excision repair_Homo sapiens_hsa034102.08415735
14Proteasome_Homo sapiens_hsa030501.99424628
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92326346
16RNA transport_Homo sapiens_hsa030131.77971879
17mRNA surveillance pathway_Homo sapiens_hsa030151.75446125
18Bladder cancer_Homo sapiens_hsa052191.74294133
19Non-homologous end-joining_Homo sapiens_hsa034501.73177875
20Protein export_Homo sapiens_hsa030601.67826252
21Cell cycle_Homo sapiens_hsa041101.65115941
22Acute myeloid leukemia_Homo sapiens_hsa052211.63018634
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57756279
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53893886
25Vibrio cholerae infection_Homo sapiens_hsa051101.47838370
26Collecting duct acid secretion_Homo sapiens_hsa049661.41498451
27Lysosome_Homo sapiens_hsa041421.39660276
28Nucleotide excision repair_Homo sapiens_hsa034201.31554388
29Non-small cell lung cancer_Homo sapiens_hsa052231.27746148
30Pyrimidine metabolism_Homo sapiens_hsa002401.26993698
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26867552
32Vitamin B6 metabolism_Homo sapiens_hsa007501.21566576
33Fatty acid elongation_Homo sapiens_hsa000621.12283832
34Chronic myeloid leukemia_Homo sapiens_hsa052201.08763752
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07759073
36Folate biosynthesis_Homo sapiens_hsa007901.06964245
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05896419
38Basal transcription factors_Homo sapiens_hsa030221.02351278
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00025129
40Prion diseases_Homo sapiens_hsa050200.95172043
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93102224
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90913592
43Sulfur metabolism_Homo sapiens_hsa009200.89207113
44Other glycan degradation_Homo sapiens_hsa005110.87394655
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85581182
46Sulfur relay system_Homo sapiens_hsa041220.85259211
47Pancreatic cancer_Homo sapiens_hsa052120.85128605
48Spliceosome_Homo sapiens_hsa030400.84545637
49Endometrial cancer_Homo sapiens_hsa052130.84040777
50RNA polymerase_Homo sapiens_hsa030200.82691355
51Oxidative phosphorylation_Homo sapiens_hsa001900.82409208
52Prostate cancer_Homo sapiens_hsa052150.81923355
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77611320
54Fanconi anemia pathway_Homo sapiens_hsa034600.76620910
55Synaptic vesicle cycle_Homo sapiens_hsa047210.76331564
56T cell receptor signaling pathway_Homo sapiens_hsa046600.75899049
57Thyroid cancer_Homo sapiens_hsa052160.75185891
58Rheumatoid arthritis_Homo sapiens_hsa053230.74543697
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74372291
60Glioma_Homo sapiens_hsa052140.70775158
61Hepatitis B_Homo sapiens_hsa051610.69534082
62Oocyte meiosis_Homo sapiens_hsa041140.67386754
63Homologous recombination_Homo sapiens_hsa034400.65331646
64Melanoma_Homo sapiens_hsa052180.64991038
65Purine metabolism_Homo sapiens_hsa002300.63933937
66Parkinsons disease_Homo sapiens_hsa050120.61257988
67Measles_Homo sapiens_hsa051620.56944209
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55626880
69HTLV-I infection_Homo sapiens_hsa051660.49895354
70FoxO signaling pathway_Homo sapiens_hsa040680.49588330
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49145195
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47575688
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.45429113
74RNA degradation_Homo sapiens_hsa030180.44161784
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43759552
76Herpes simplex infection_Homo sapiens_hsa051680.41896757
77Renal cell carcinoma_Homo sapiens_hsa052110.41268248
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.40799498
79B cell receptor signaling pathway_Homo sapiens_hsa046620.39168210
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.36590776
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35840017
82Influenza A_Homo sapiens_hsa051640.35758019
83Insulin signaling pathway_Homo sapiens_hsa049100.34961222
84Allograft rejection_Homo sapiens_hsa053300.34694109
85Autoimmune thyroid disease_Homo sapiens_hsa053200.32525260
86Hepatitis C_Homo sapiens_hsa051600.32348248
87Metabolic pathways_Homo sapiens_hsa011000.31162835
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.31150044
89mTOR signaling pathway_Homo sapiens_hsa041500.30980525
90Selenocompound metabolism_Homo sapiens_hsa004500.30551201
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29846702
92Epstein-Barr virus infection_Homo sapiens_hsa051690.29336855
93Colorectal cancer_Homo sapiens_hsa052100.28992260
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28947880
95Apoptosis_Homo sapiens_hsa042100.28757251
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.28365881
97Huntingtons disease_Homo sapiens_hsa050160.27883605
98ErbB signaling pathway_Homo sapiens_hsa040120.26967137
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26575881
100Sphingolipid metabolism_Homo sapiens_hsa006000.25354793

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