ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* mesoderm development (GO:0007498)	7.90128474
2	* mesenchyme development (GO:0060485)	7.35835179
3	sex differentiation (GO:0007548)	6.53138334
4	* gonadal mesoderm development (GO:0007506)	58.6951161
5	N-acetylneuraminate metabolic process (GO:0006054)	5.18450009
6	* nucleosome assembly (GO:0006334)	4.82778262
7	* protein-DNA complex assembly (GO:0065004)	4.18685138
8	* nucleosome organization (GO:0034728)	3.92412792
9	ribosomal small subunit assembly (GO:0000028)	3.74111079
10	ribosomal small subunit biogenesis (GO:0042274)	3.70008768
11	* protein-DNA complex subunit organization (GO:0071824)	3.50609663
12	piRNA metabolic process (GO:0034587)	3.22747620
13	regulation of meiosis I (GO:0060631)	3.13346925
14	regulation of activation of Janus kinase activity (GO:0010533)	2.68244057
15	positive regulation of translational initiation (GO:0045948)	2.67299358
16	mitotic chromosome condensation (GO:0007076)	2.58823586
17	formation of translation preinitiation complex (GO:0001731)	2.58630354
18	interleukin-6-mediated signaling pathway (GO:0070102)	2.53225024
19	positive regulation of meiosis (GO:0045836)	2.50156128
20	viral transcription (GO:0019083)	2.46047906
21	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.44526933
22	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.44526933
23	translational termination (GO:0006415)	2.41157821
24	positive regulation of meiotic cell cycle (GO:0051446)	2.32992957
25	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.31266731
26	cotranslational protein targeting to membrane (GO:0006613)	2.26911309
27	meiotic chromosome segregation (GO:0045132)	2.25409818
28	protein localization to endoplasmic reticulum (GO:0070972)	2.24969009
29	translational elongation (GO:0006414)	2.24703651
30	protein targeting to ER (GO:0045047)	2.23253964
31	regulation of isotype switching to IgG isotypes (GO:0048302)	2.22924956
32	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.15262326
33	apoptotic cell clearance (GO:0043277)	2.06480898
34	protein K63-linked deubiquitination (GO:0070536)	2.04060671
35	viral life cycle (GO:0019058)	2.03809565
36	positive regulation of viral genome replication (GO:0045070)	2.02388946
37	translational initiation (GO:0006413)	2.00380608
38	mitotic metaphase plate congression (GO:0007080)	1.99741065
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	1.99161504
40	synapsis (GO:0007129)	1.97933287
41	ribonucleoprotein complex biogenesis (GO:0022613)	1.97360937
42	protein K48-linked deubiquitination (GO:0071108)	1.97026147
43	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	1.96667978
44	* male gamete generation (GO:0048232)	1.96358621
45	* spermatogenesis (GO:0007283)	1.96336819
46	male meiosis (GO:0007140)	1.95331167
47	Golgi transport vesicle coating (GO:0048200)	1.95078739
48	COPI coating of Golgi vesicle (GO:0048205)	1.95078739
49	sialylation (GO:0097503)	1.94399637
50	establishment of integrated proviral latency (GO:0075713)	1.91590474
51	negative regulation of meiosis (GO:0045835)	1.90952579
52	mitotic sister chromatid cohesion (GO:0007064)	1.90825553
53	cellular protein complex disassembly (GO:0043624)	1.86161610
54	nucleotide transmembrane transport (GO:1901679)	1.81878461
55	* gamete generation (GO:0007276)	1.79708562
56	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	1.74790935
57	regulation of translational initiation (GO:0006446)	1.70686237
58	protein targeting to membrane (GO:0006612)	1.70559684
59	ribosome biogenesis (GO:0042254)	1.70139592
60	nucleotide transport (GO:0006862)	1.69084018
61	negative regulation of Notch signaling pathway (GO:0045746)	1.67257520
62	proline biosynthetic process (GO:0006561)	1.66545250
63	protein K6-linked ubiquitination (GO:0085020)	1.62881529
64	* reproductive structure development (GO:0048608)	1.62610017
65	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	1.62133505
66	regulation of translational fidelity (GO:0006450)	1.61828149
67	gene silencing by RNA (GO:0031047)	1.60260235
68	regulation of meiosis (GO:0040020)	1.59255697
69	protein complex disassembly (GO:0043241)	1.57923983
70	translation (GO:0006412)	1.57710419
71	positive regulation of alpha-beta T cell proliferation (GO:0046641)	1.57544928
72	chaperone mediated protein folding requiring cofactor (GO:0051085)	1.57436601
73	viral protein processing (GO:0019082)	1.57022693
74	proteasome assembly (GO:0043248)	1.56874451
75	male sex determination (GO:0030238)	1.55834292
76	DNA catabolic process, exonucleolytic (GO:0000738)	1.55626679
77	cellular response to interleukin-6 (GO:0071354)	1.55553288
78	germ cell migration (GO:0008354)	1.54949783
79	ncRNA 3-end processing (GO:0043628)	1.52868832
80	protein N-linked glycosylation via asparagine (GO:0018279)	1.52317600
81	chromosome organization involved in meiosis (GO:0070192)	1.50000770
82	male meiosis I (GO:0007141)	1.49955348
83	DNA strand elongation involved in DNA replication (GO:0006271)	1.49850331
84	peptidyl-asparagine modification (GO:0018196)	1.49820405
85	organ or tissue specific immune response (GO:0002251)	1.49717560
86	meiotic nuclear division (GO:0007126)	1.49490037
87	DNA strand elongation (GO:0022616)	1.48982204
88	DNA replication initiation (GO:0006270)	1.48143571
89	somatic hypermutation of immunoglobulin genes (GO:0016446)	1.48037405
90	somatic diversification of immune receptors via somatic mutation (GO:0002566)	1.48037405
91	regulation of sister chromatid cohesion (GO:0007063)	1.47419661
92	sodium ion homeostasis (GO:0055078)	1.47143520
93	macromolecular complex disassembly (GO:0032984)	1.46466682
94	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	1.46243224
95	cellular sodium ion homeostasis (GO:0006883)	1.45903409
96	metaphase plate congression (GO:0051310)	1.45794999
97	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	1.45624488
98	regulation of penile erection (GO:0060405)	1.45251197
99	N-terminal protein amino acid acetylation (GO:0006474)	1.44786109
100	purine ribonucleotide transport (GO:0015868)	1.44743294

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.40829309
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.00774289
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.87111988
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.82565113
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.74449753
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.17593936
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.14890021
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10534421
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.02956439
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.91035690
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.84891662
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.80721000
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.68206646
14	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.63831880
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.59057376
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.54765482
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.49204312
18	TFEB_21752829_ChIP-Seq_HELA_Human	2.45853095
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.41986106
20	DCP1A_22483619_ChIP-Seq_HELA_Human	2.41927860
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.40054358
22	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.28271376
23	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.19218998
24	TTF2_22483619_ChIP-Seq_HELA_Human	2.16253964
25	VDR_23849224_ChIP-Seq_CD4+_Human	2.15959718
26	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15400638
27	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.15276135
28	GABP_19822575_ChIP-Seq_HepG2_Human	2.05694157
29	FOXP3_21729870_ChIP-Seq_TREG_Human	2.04878315
30	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.03695905
31	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.97728358
32	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.95889897
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.95166825
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92692222
35	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.89503043
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.88763932
37	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.87953702
38	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.82941377
39	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.79615470
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.78188498
41	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.77842920
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74588369
43	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.68780812
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.64358894
45	CIITA_25753668_ChIP-Seq_RAJI_Human	1.63137177
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.62019379
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61426365
48	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.61127373
49	MYC_22102868_ChIP-Seq_BL_Human	1.60876952
50	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.59907404
51	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.58092943
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.53360928
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.52153338
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50184461
55	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.46038330
56	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.42672404
57	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.41658677
58	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.41320811
59	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.41286320
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.39058410
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39045184
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38494333
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36601079
64	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36546712
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.35019029
66	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.33865229
67	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.29927479
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26265084
69	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24465122
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23806253
71	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23311951
72	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.19934120
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.19687075
74	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.16517230
75	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.16517230
76	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.16517230
77	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.06673821
78	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	1.03508516
79	MYB_26560356_Chip-Seq_TH2_Human	1.02941550
80	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.01803027
81	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.01802513
82	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.98155394
83	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.96804520
84	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.96756351
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.93476348
86	ZNF263_19887448_ChIP-Seq_K562_Human	0.92228065
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.89265431
88	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.87842340
89	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.86801582
90	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.84202284
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.81785121
92	AR_21909140_ChIP-Seq_LNCAP_Human	0.81563270
93	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.81330997
94	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.80755229
95	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.79670739
96	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.79010511
97	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.78022221
98	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.77653944
99	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.76657259
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75885091

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	6.70832706
2	MP0003136_yellow_coat_color	4.46613663
3	MP0003693_abnormal_embryo_hatching	4.09964667
4	MP0005058_abnormal_lysosome_morphology	3.72073676
5	MP0004147_increased_porphyrin_level	3.56398380
6	MP0005171_absent_coat_pigmentation	3.10120286
7	MP0004957_abnormal_blastocyst_morpholog	3.06770709
8	MP0009333_abnormal_splenocyte_physiolog	2.85078944
9	MP0003111_abnormal_nucleus_morphology	2.77119642
10	MP0005174_abnormal_tail_pigmentation	2.71144222
11	MP0008995_early_reproductive_senescence	2.67810835
12	MP0008057_abnormal_DNA_replication	2.44327788
13	MP0003077_abnormal_cell_cycle	2.22868697
14	MP0002210_abnormal_sex_determination	2.03657898
15	MP0001929_abnormal_gametogenesis	1.94691741
16	MP0003183_abnormal_peptide_metabolism	1.93655397
17	MP0008932_abnormal_embryonic_tissue	1.91425421
18	MP0008058_abnormal_DNA_repair	1.89939283
19	MP0010368_abnormal_lymphatic_system	1.81032689
20	MP0005451_abnormal_body_composition	1.80848000
21	MP0001145_abnormal_male_reproductive	1.80591542
22	MP0001188_hyperpigmentation	1.76493299
23	MP0010307_abnormal_tumor_latency	1.70719985
24	MP0005075_abnormal_melanosome_morpholog	1.65617436
25	MP0008877_abnormal_DNA_methylation	1.58565634
26	MP0001730_embryonic_growth_arrest	1.58495884
27	MP0003786_premature_aging	1.56323025
28	MP0001348_abnormal_lacrimal_gland	1.55802086
29	MP0000350_abnormal_cell_proliferation	1.53785317
30	MP0000653_abnormal_sex_gland	1.52680572
31	MP0009840_abnormal_foam_cell	1.51192450
32	MP0003698_abnormal_male_reproductive	1.51127740
33	MP0005408_hypopigmentation	1.50260379
34	MP0005671_abnormal_response_to	1.47700078
35	MP0003806_abnormal_nucleotide_metabolis	1.43129260
36	MP0002877_abnormal_melanocyte_morpholog	1.40909859
37	MP0000747_muscle_weakness	1.39147515
38	MP0010094_abnormal_chromosome_stability	1.35554532
39	MP0002168_other_aberrant_phenotype	1.34994590
40	MP0000372_irregular_coat_pigmentation	1.33467118
41	MP0005395_other_phenotype	1.26705391
42	MP0003763_abnormal_thymus_physiology	1.26565025
43	MP0003172_abnormal_lysosome_physiology	1.14799639
44	MP0000313_abnormal_cell_death	1.13950768
45	MP0005670_abnormal_white_adipose	1.13572900
46	MP0002095_abnormal_skin_pigmentation	1.13536428
47	MP0002080_prenatal_lethality	1.12014022
48	MP0003718_maternal_effect	1.08579777
49	MP0008007_abnormal_cellular_replicative	1.08050137
50	MP0003656_abnormal_erythrocyte_physiolo	1.06515141
51	MP0000358_abnormal_cell_content/	1.06427216
52	MP0004043_abnormal_pH_regulation	1.06163828
53	MP0001663_abnormal_digestive_system	1.05042954
54	MP0001697_abnormal_embryo_size	1.04576760
55	MP0003186_abnormal_redox_activity	1.01116541
56	MP0005220_abnormal_exocrine_pancreas	1.00594770
57	MP0002075_abnormal_coat/hair_pigmentati	0.97728505
58	MP0008260_abnormal_autophagy	0.97696991
59	MP0003646_muscle_fatigue	0.92351940
60	MP0003943_abnormal_hepatobiliary_system	0.91838139
61	MP0001661_extended_life_span	0.90898094
62	MP0002161_abnormal_fertility/fecundity	0.86456643
63	MP0000689_abnormal_spleen_morphology	0.85346070
64	MP0005464_abnormal_platelet_physiology	0.84636617
65	MP0002398_abnormal_bone_marrow	0.83309626
66	MP0001186_pigmentation_phenotype	0.83082533
67	MP0002796_impaired_skin_barrier	0.82571696
68	MP0005381_digestive/alimentary_phenotyp	0.81426754
69	MP0004233_abnormal_muscle_weight	0.79776410
70	MP0009379_abnormal_foot_pigmentation	0.78328556
71	MP0006035_abnormal_mitochondrial_morpho	0.78121943
72	MP0008569_lethality_at_weaning	0.77352030
73	MP0003959_abnormal_lean_body	0.76894359
74	MP0002090_abnormal_vision	0.75354181
75	MP0002751_abnormal_autonomic_nervous	0.74887182
76	MP0003221_abnormal_cardiomyocyte_apopto	0.72904070
77	MP0002429_abnormal_blood_cell	0.72882141
78	MP0000703_abnormal_thymus_morphology	0.72289644
79	MP0001324_abnormal_eye_pigmentation	0.71085835
80	MP0001542_abnormal_bone_strength	0.70364731
81	MP0005410_abnormal_fertilization	0.68642184
82	MP0009643_abnormal_urine_homeostasis	0.68539388
83	MP0001666_abnormal_nutrient_absorption	0.67455169
84	MP0000598_abnormal_liver_morphology	0.66352187
85	MP0006036_abnormal_mitochondrial_physio	0.64157802
86	MP0000371_diluted_coat_color	0.63925777
87	MP0004215_abnormal_myocardial_fiber	0.62736083
88	MP0002019_abnormal_tumor_incidence	0.62624169
89	MP0004808_abnormal_hematopoietic_stem	0.61928466
90	MP0000716_abnormal_immune_system	0.61770947
91	MP0001919_abnormal_reproductive_system	0.61006308
92	MP0005384_cellular_phenotype	0.60528449
93	MP0002084_abnormal_developmental_patter	0.60339732
94	MP0002722_abnormal_immune_system	0.60140556
95	MP0009785_altered_susceptibility_to	0.59466738
96	MP0002822_catalepsy	0.57820325
97	MP0002086_abnormal_extraembryonic_tissu	0.57694702
98	MP0000490_abnormal_crypts_of	0.57598316
99	MP0001119_abnormal_female_reproductive	0.57447511
100	MP0004197_abnormal_fetal_growth/weight/	0.57230301

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Vacuolated lymphocytes (HP:0001922)	4.62976178
2	Carpal bone hypoplasia (HP:0001498)	3.90672295
3	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.81111628
4	Back pain (HP:0003418)	3.71467378
5	Patchy hypopigmentation of hair (HP:0011365)	3.69604910
6	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.66802040
7	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.66802040
8	Increased cerebral lipofuscin (HP:0011813)	3.65023637
9	Reticulocytopenia (HP:0001896)	3.44907241
10	Vertebral compression fractures (HP:0002953)	3.44529213
11	Abnormal number of erythroid precursors (HP:0012131)	3.41127199
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.28417213
13	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.23571655
14	Abnormal auditory evoked potentials (HP:0006958)	3.20171405
15	Nonimmune hydrops fetalis (HP:0001790)	3.17885593
16	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.17532440
17	White forelock (HP:0002211)	3.13060196
18	Hypoplasia of the uterus (HP:0000013)	3.09693190
19	Albinism (HP:0001022)	3.09427438
20	Short middle phalanx of the 5th finger (HP:0004220)	3.01237189
21	Abnormality of glycolipid metabolism (HP:0010969)	2.99793634
22	Abnormality of liposaccharide metabolism (HP:0010968)	2.99793634
23	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.99793634
24	Abnormal protein glycosylation (HP:0012346)	2.97842312
25	Abnormal glycosylation (HP:0012345)	2.97842312
26	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.97842312
27	Abnormal protein N-linked glycosylation (HP:0012347)	2.97842312
28	Dysostosis multiplex (HP:0000943)	2.97255911
29	Type I transferrin isoform profile (HP:0003642)	2.85236057
30	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.85026528
31	Acute hepatic failure (HP:0006554)	2.84657457
32	Large for gestational age (HP:0001520)	2.77185280
33	Abnormality of the corticospinal tract (HP:0002492)	2.76835137
34	Gonadal dysgenesis (HP:0000133)	2.76225927
35	Basal cell carcinoma (HP:0002671)	2.73172508
36	Decreased circulating renin level (HP:0003351)	2.72227086
37	Hyperactive renin-angiotensin system (HP:0000841)	2.65400272
38	Spastic paraparesis (HP:0002313)	2.59243734
39	Upper limb muscle weakness (HP:0003484)	2.56446678
40	Cutaneous melanoma (HP:0012056)	2.53916818
41	Abnormal tarsal ossification (HP:0008369)	2.45333742
42	Global brain atrophy (HP:0002283)	2.44486415
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.41369279
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.41369279
45	Reduced antithrombin III activity (HP:0001976)	2.40172627
46	Ankyloglossia (HP:0010296)	2.37883094
47	Hyperglycinuria (HP:0003108)	2.36539735
48	Hyperlipoproteinemia (HP:0010980)	2.36421433
49	Lower limb hyperreflexia (HP:0002395)	2.32726087
50	Exocrine pancreatic insufficiency (HP:0001738)	2.30402033
51	Hyponatremia (HP:0002902)	2.28559597
52	Aplasia/hypoplasia of the uterus (HP:0008684)	2.25644244
53	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.23458153
54	Autoimmune hemolytic anemia (HP:0001890)	2.23002544
55	Beaking of vertebral bodies (HP:0004568)	2.22487119
56	Volvulus (HP:0002580)	2.19957250
57	Small epiphyses (HP:0010585)	2.17591008
58	Squamous cell carcinoma (HP:0002860)	2.15922180
59	Macrocytic anemia (HP:0001972)	2.14266933
60	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12981299
61	Pallor (HP:0000980)	2.12294475
62	Overlapping toe (HP:0001845)	2.09346604
63	Osteomalacia (HP:0002749)	2.05491990
64	Urethral obstruction (HP:0000796)	2.05197193
65	Hypercortisolism (HP:0001578)	2.04207736
66	Microretrognathia (HP:0000308)	2.03934791
67	Exercise-induced myalgia (HP:0003738)	2.03758652
68	Recurrent cutaneous fungal infections (HP:0011370)	2.03620726
69	Chronic mucocutaneous candidiasis (HP:0002728)	2.03620726
70	CNS hypomyelination (HP:0003429)	2.02841743
71	Abnormality of the distal phalanges of the toes (HP:0010182)	2.02637179
72	Esophageal neoplasm (HP:0100751)	2.00188514
73	Neoplasm of head and neck (HP:0012288)	2.00188514
74	Abnormality of oral frenula (HP:0000190)	1.98490901
75	Abnormality of the lumbar spine (HP:0100712)	1.97110239
76	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96824963
77	Birth length less than 3rd percentile (HP:0003561)	1.94070291
78	Long palpebral fissure (HP:0000637)	1.93338725
79	Onycholysis (HP:0001806)	1.92428632
80	Erythema (HP:0010783)	1.92403508
81	Tetraparesis (HP:0002273)	1.91766152
82	Abnormality of reticulocytes (HP:0004312)	1.90714313
83	Impulsivity (HP:0100710)	1.90646223
84	Abnormal foot bone ossification (HP:0010675)	1.90074284
85	Cerebral hypomyelination (HP:0006808)	1.89462818
86	Abnormality of small intestinal villus morphology (HP:0011472)	1.89152033
87	Villous atrophy (HP:0011473)	1.89152033
88	Death in infancy (HP:0001522)	1.87926338
89	Hypokalemic alkalosis (HP:0001949)	1.85223590
90	Cortical dysplasia (HP:0002539)	1.83402085
91	Progressive neurologic deterioration (HP:0002344)	1.83246191
92	Hypokinesia (HP:0002375)	1.81857502
93	Abnormality of the thoracic spine (HP:0100711)	1.80295272
94	Abnormality of fatty-acid metabolism (HP:0004359)	1.80185953
95	Thoracolumbar scoliosis (HP:0002944)	1.79589282
96	Deep palmar crease (HP:0006191)	1.78751036
97	Death in childhood (HP:0003819)	1.78672224
98	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.77864979
99	Thoracic kyphosis (HP:0002942)	1.73864470
100	Unsteady gait (HP:0002317)	1.73821827

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	5.24121009
2	CDK19	4.66737246
3	EIF2AK3	3.92993973
4	KSR2	3.34643364
5	TAF1	3.20171661
6	ACVR1B	3.16317355
7	CDC7	2.99978277
8	TAOK2	2.86231319
9	BRAF	2.70317097
10	ARAF	2.65634131
11	SCYL2	2.49980059
12	TESK2	2.21922062
13	NME2	2.14771104
14	TTK	2.08813747
15	BUB1	2.02912571
16	ITK	1.93533523
17	ERN1	1.90394492
18	MAP3K9	1.77593320
19	IRAK3	1.76672771
20	RAF1	1.68920756
21	STK16	1.55204005
22	PNCK	1.52338091
23	CDK3	1.48235640
24	MAP3K2	1.42786422
25	WEE1	1.39919644
26	MAP3K8	1.32974848
27	BRSK1	1.31812387
28	KSR1	1.26026872
29	RPS6KB2	1.23483419
30	WNK4	1.23448335
31	CDK8	1.21446554
32	MAP3K1	1.15530400
33	MAP3K10	1.07716814
34	EEF2K	1.07337608
35	MAP3K13	1.06877488
36	MATK	1.06175283
37	MAPK7	0.90744986
38	STK10	0.90661038
39	NME1	0.90000640
40	PBK	0.88363164
41	STK39	0.86467520
42	JAK2	0.78484298
43	PLK4	0.77906726
44	RPS6KB1	0.75742696
45	PLK1	0.74440280
46	ATR	0.74298029
47	CDK7	0.73693823
48	MOS	0.72242118
49	CDK11A	0.70288115
50	PIM1	0.67303627
51	AURKA	0.65649054
52	PAK2	0.64770142
53	CHEK1	0.62974378
54	AKT2	0.62138608
55	CHEK2	0.59470178
56	CSNK2A1	0.59023535
57	CDK14	0.58214082
58	INSRR	0.55049453
59	RPS6KC1	0.54197866
60	RPS6KL1	0.54197866
61	MAP3K12	0.50260273
62	LRRK2	0.48834438
63	ICK	0.47868523
64	BCKDK	0.47448843
65	NEK1	0.46846594
66	STK24	0.46615585
67	MARK3	0.46319396
68	SRPK1	0.46265574
69	RPS6KA6	0.45933200
70	IRAK2	0.45139464
71	KIT	0.43478298
72	PASK	0.43079820
73	MAP3K11	0.42410277
74	NTRK3	0.42070810
75	CDK15	0.41486452
76	PAK1	0.39823950
77	GRK6	0.39183239
78	BMPR1B	0.38853391
79	AURKB	0.38547495
80	IRAK4	0.37697003
81	CDK18	0.34764742
82	CSF1R	0.34753604
83	DYRK1B	0.34743671
84	DAPK2	0.33082980
85	CCNB1	0.32400451
86	MAPK12	0.30815957
87	CSNK2A2	0.30737347
88	CSNK1G2	0.30491080
89	NEK2	0.29887940
90	ATM	0.29762050
91	PRKCI	0.28972667
92	CDK2	0.27996475
93	CDK12	0.26448463
94	CDK1	0.26339483
95	RPS6KA1	0.25785833
96	MAP2K1	0.25480696
97	CLK1	0.24095552
98	ALK	0.23279881
99	NEK6	0.21854838
100	TRIM28	0.21095886

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	N-Glycan biosynthesis_Homo sapiens_hsa00510	4.43559350
2	Ribosome_Homo sapiens_hsa03010	4.16038708
3	DNA replication_Homo sapiens_hsa03030	3.79812351
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.84973852
5	Mismatch repair_Homo sapiens_hsa03430	2.63746854
6	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.59766835
7	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.56974519
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.56778315
9	Proteasome_Homo sapiens_hsa03050	2.38692890
10	RNA transport_Homo sapiens_hsa03013	2.28140502
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.26357306
12	Base excision repair_Homo sapiens_hsa03410	2.15434542
13	One carbon pool by folate_Homo sapiens_hsa00670	2.06550171
14	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.04222527
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01943820
16	Protein export_Homo sapiens_hsa03060	1.95138316
17	mRNA surveillance pathway_Homo sapiens_hsa03015	1.95078025
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.89148078
19	Cell cycle_Homo sapiens_hsa04110	1.82692452
20	Bladder cancer_Homo sapiens_hsa05219	1.67730148
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.57684238
22	Fatty acid elongation_Homo sapiens_hsa00062	1.55779522
23	Basal transcription factors_Homo sapiens_hsa03022	1.52868086
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.46895871
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45104361
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.44954256
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39849095
28	Acute myeloid leukemia_Homo sapiens_hsa05221	1.39152243
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.29746720
30	Vibrio cholerae infection_Homo sapiens_hsa05110	1.29597657
31	Homologous recombination_Homo sapiens_hsa03440	1.27125875
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25532856
33	Lysosome_Homo sapiens_hsa04142	1.25273095
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20885095
35	Parkinsons disease_Homo sapiens_hsa05012	1.13388029
36	Prion diseases_Homo sapiens_hsa05020	1.13151716
37	RNA polymerase_Homo sapiens_hsa03020	1.06365787
38	Folate biosynthesis_Homo sapiens_hsa00790	1.05967801
39	Spliceosome_Homo sapiens_hsa03040	1.05705790
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.03898501
41	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.00369664
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00128270
43	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.97356623
44	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.94977133
45	RNA degradation_Homo sapiens_hsa03018	0.87833364
46	Non-small cell lung cancer_Homo sapiens_hsa05223	0.87374968
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85345200
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.85338840
49	Other glycan degradation_Homo sapiens_hsa00511	0.84815111
50	Alzheimers disease_Homo sapiens_hsa05010	0.82024087
51	Huntingtons disease_Homo sapiens_hsa05016	0.75536977
52	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74162805
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73923773
54	Sulfur metabolism_Homo sapiens_hsa00920	0.72934580
55	Purine metabolism_Homo sapiens_hsa00230	0.68076498
56	Oocyte meiosis_Homo sapiens_hsa04114	0.67865912
57	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.67208449
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.66609379
59	Viral myocarditis_Homo sapiens_hsa05416	0.63614353
60	Allograft rejection_Homo sapiens_hsa05330	0.61314845
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61205207
62	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.59667010
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.58915048
64	Hepatitis B_Homo sapiens_hsa05161	0.58254981
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57874187
66	Pancreatic cancer_Homo sapiens_hsa05212	0.57822773
67	p53 signaling pathway_Homo sapiens_hsa04115	0.56561958
68	Prostate cancer_Homo sapiens_hsa05215	0.56061101
69	Melanoma_Homo sapiens_hsa05218	0.54505848
70	Herpes simplex infection_Homo sapiens_hsa05168	0.53815834
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.52974004
72	Measles_Homo sapiens_hsa05162	0.48111081
73	Sulfur relay system_Homo sapiens_hsa04122	0.47748041
74	HTLV-I infection_Homo sapiens_hsa05166	0.47176017
75	Glioma_Homo sapiens_hsa05214	0.46737176
76	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45906532
77	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44289406
78	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.41964413
79	Thyroid cancer_Homo sapiens_hsa05216	0.40197849
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38999698
81	Metabolic pathways_Homo sapiens_hsa01100	0.38493613
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38138184
83	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.38069054
84	Influenza A_Homo sapiens_hsa05164	0.36576506
85	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.33876159
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32995356
87	mTOR signaling pathway_Homo sapiens_hsa04150	0.31811696
88	Viral carcinogenesis_Homo sapiens_hsa05203	0.31485361
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30918997
90	Endometrial cancer_Homo sapiens_hsa05213	0.30087517
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.28786104
92	Insulin signaling pathway_Homo sapiens_hsa04910	0.27064988
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.26996318
94	FoxO signaling pathway_Homo sapiens_hsa04068	0.26829719
95	Apoptosis_Homo sapiens_hsa04210	0.26744859
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.25333837
97	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.23597996
98	Carbon metabolism_Homo sapiens_hsa01200	0.21917110
99	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.19693641
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.19308242

TSPY8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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