ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mesoderm development (GO:0007498)	9.17866806
2	mesenchyme development (GO:0060485)	8.43192991
3	gonadal mesoderm development (GO:0007506)	61.2072243
4	sex differentiation (GO:0007548)	5.90551732
5	N-acetylneuraminate metabolic process (GO:0006054)	5.56232963
6	nucleosome assembly (GO:0006334)	5.50079579
7	protein-DNA complex assembly (GO:0065004)	4.70195411
8	nucleosome organization (GO:0034728)	4.48766040
9	protein-DNA complex subunit organization (GO:0071824)	3.95081512
10	ribosomal small subunit biogenesis (GO:0042274)	3.30578623
11	ribosomal small subunit assembly (GO:0000028)	2.91293996
12	interleukin-6-mediated signaling pathway (GO:0070102)	2.77295274
13	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.72419903
14	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.72419903
15	regulation of activation of Janus kinase activity (GO:0010533)	2.72234620
16	apoptotic cell clearance (GO:0043277)	2.39498465
17	sialylation (GO:0097503)	2.26338662
18	regulation of isotype switching to IgG isotypes (GO:0048302)	2.22987800
19	mitotic chromosome condensation (GO:0007076)	2.06560835
20	positive regulation of viral genome replication (GO:0045070)	2.05833972
21	formation of translation preinitiation complex (GO:0001731)	2.05205979
22	piRNA metabolic process (GO:0034587)	2.00119882
23	viral transcription (GO:0019083)	1.99862745
24	N-glycan processing (GO:0006491)	1.98629808
25	protein K48-linked deubiquitination (GO:0071108)	1.96841386
26	protein K63-linked deubiquitination (GO:0070536)	1.96079398
27	translational termination (GO:0006415)	1.94651385
28	regulation of translational fidelity (GO:0006450)	1.94167893
29	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	1.92319524
30	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	1.92058871
31	protein localization to endoplasmic reticulum (GO:0070972)	1.87982527
32	spermatogenesis (GO:0007283)	1.87191839
33	cotranslational protein targeting to membrane (GO:0006613)	1.87094224
34	translational elongation (GO:0006414)	1.87039812
35	male gamete generation (GO:0048232)	1.86591609
36	protein targeting to ER (GO:0045047)	1.86462982
37	negative regulation of Notch signaling pathway (GO:0045746)	1.85703254
38	reproductive structure development (GO:0048608)	1.84908314
39	ribonucleoprotein complex biogenesis (GO:0022613)	1.84862621
40	establishment of integrated proviral latency (GO:0075713)	1.81160741
41	Golgi transport vesicle coating (GO:0048200)	1.80583424
42	COPI coating of Golgi vesicle (GO:0048205)	1.80583424
43	establishment of protein localization to endoplasmic reticulum (GO:0072599)	1.79223277
44	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	1.76920847
45	proline biosynthetic process (GO:0006561)	1.75321293
46	cellular response to interleukin-6 (GO:0071354)	1.73850943
47	positive regulation of mitochondrial membrane permeability (GO:0035794)	1.70720544
48	ribosome biogenesis (GO:0042254)	1.69386826
49	gamete generation (GO:0007276)	1.69175484
50	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	1.66717047
51	amyloid precursor protein catabolic process (GO:0042987)	1.66024943
52	ganglioside metabolic process (GO:0001573)	1.64473874
53	viral life cycle (GO:0019058)	1.63880418
54	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	1.62763286
55	meiotic chromosome segregation (GO:0045132)	1.62735268
56	positive regulation of alpha-beta T cell proliferation (GO:0046641)	1.62531006
57	protein N-linked glycosylation via asparagine (GO:0018279)	1.61487762
58	translational initiation (GO:0006413)	1.59958868
59	peptidyl-asparagine modification (GO:0018196)	1.59876207
60	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	1.58226874
61	amyloid precursor protein metabolic process (GO:0042982)	1.56822978
62	cellular sodium ion homeostasis (GO:0006883)	1.54539400
63	cellular protein complex disassembly (GO:0043624)	1.49644933
64	neutrophil mediated immunity (GO:0002446)	1.48259679
65	chaperone mediated protein folding requiring cofactor (GO:0051085)	1.48046132
66	protein N-linked glycosylation (GO:0006487)	1.47616304
67	modulation by virus of host process (GO:0019054)	1.47577204
68	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	1.46669410
69	negative thymic T cell selection (GO:0045060)	1.46454725
70	establishment of viral latency (GO:0019043)	1.43611569
71	regulation of chromatin binding (GO:0035561)	1.43468940
72	protein targeting to membrane (GO:0006612)	1.41685336
73	mitotic metaphase plate congression (GO:0007080)	1.41498924
74	mitotic nuclear envelope disassembly (GO:0007077)	1.40863413
75	amino sugar metabolic process (GO:0006040)	1.40805707
76	deoxyribonucleotide biosynthetic process (GO:0009263)	1.40010380
77	ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	1.39536717
78	mitochondrial DNA metabolic process (GO:0032042)	1.38098683
79	sodium ion homeostasis (GO:0055078)	1.37557243
80	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	1.36665426
81	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	1.36019501
82	response to interleukin-6 (GO:0070741)	1.35948716
83	DNA methylation involved in gamete generation (GO:0043046)	1.35761346
84	nuclear envelope disassembly (GO:0051081)	1.35689309
85	membrane disassembly (GO:0030397)	1.35689309
86	mitotic sister chromatid cohesion (GO:0007064)	1.35332355
87	DNA unwinding involved in DNA replication (GO:0006268)	1.34949681
88	protein complex disassembly (GO:0043241)	1.33476396
89	ER overload response (GO:0006983)	1.33396361
90	multicellular organismal reproductive process (GO:0048609)	1.33387973
91	DNA replication initiation (GO:0006270)	1.32991681
92	complement activation, classical pathway (GO:0006958)	1.31258908
93	cellular component biogenesis (GO:0044085)	1.30892423
94	regulation of penile erection (GO:0060405)	1.30853281
95	negative T cell selection (GO:0043383)	1.28968618
96	DNA strand elongation involved in DNA replication (GO:0006271)	1.28883718
97	organ or tissue specific immune response (GO:0002251)	1.28582750
98	DNA strand elongation (GO:0022616)	1.28474197
99	translation (GO:0006412)	1.28326966
100	protoporphyrinogen IX metabolic process (GO:0046501)	1.28051426

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.08706744
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.82861245
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.68645155
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.61443026
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29758164
6	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.24437553
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.12035048
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.97591729
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.80098180
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.79456181
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.68347734
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55521751
13	TFEB_21752829_ChIP-Seq_HELA_Human	2.55377167
14	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.53076252
15	MYC_22102868_ChIP-Seq_BL_Human	2.43241819
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.41648952
17	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.37911486
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.33372974
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.32132239
20	DCP1A_22483619_ChIP-Seq_HELA_Human	2.31689203
21	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	2.16361963
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.11612953
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10455296
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.07670201
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.07621616
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.04453598
27	CIITA_25753668_ChIP-Seq_RAJI_Human	2.02716093
28	GABP_19822575_ChIP-Seq_HepG2_Human	2.02689057
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.00372181
30	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.97286413
31	GATA1_22025678_ChIP-Seq_K562_Human	1.96935134
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.94522598
33	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.92342377
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.85671221
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81387334
36	VDR_23849224_ChIP-Seq_CD4+_Human	1.80699372
37	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.77007796
38	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.76961663
39	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.76510756
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.73954623
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.71715209
42	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.70823376
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.70779025
44	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.68332175
45	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.68085476
46	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.66917051
47	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.64457114
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.64456191
49	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.62979025
50	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.62218209
51	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.59064327
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.58972664
53	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.58194284
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.56154759
55	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.52120755
56	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.50858087
57	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.50202953
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49313586
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43297617
60	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.41160281
61	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39966224
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35827445
63	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.35596419
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34353702
65	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.32551742
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25422830
67	VDR_21846776_ChIP-Seq_THP-1_Human	1.24006323
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22319914
69	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	1.21763385
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18990161
71	SCL_19346495_ChIP-Seq_HPC-7_Human	1.18421573
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.16579202
73	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14871592
74	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.09862689
75	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.09131308
76	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.03971775
77	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03771742
78	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.02135776
79	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99700083
80	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.99551930
81	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99107466
82	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.98220381
83	NCOR1_26117541_ChIP-Seq_K562_Human	0.94822819
84	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.92158669
85	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.91755500
86	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.90771463
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88789672
88	MYB_26560356_Chip-Seq_TH2_Human	0.88007190
89	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.87696350
90	MAF_26560356_Chip-Seq_TH2_Human	0.87522667
91	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.85972774
92	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.85344631
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.84812823
94	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.84135829
95	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.84108845
96	IGF1R_20145208_ChIP-Seq_DFB_Human	0.82620750
97	MYB_26560356_Chip-Seq_TH1_Human	0.80558487
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80357627
99	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.78339746
100	GATA1_19941826_ChIP-Seq_K562_Human	0.77482986

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	8.45046712
2	MP0003136_yellow_coat_color	5.26289623
3	MP0005171_absent_coat_pigmentation	4.20578655
4	MP0003693_abnormal_embryo_hatching	3.66033977
5	MP0008995_early_reproductive_senescence	3.48951024
6	MP0005058_abnormal_lysosome_morphology	3.35050132
7	MP0009333_abnormal_splenocyte_physiolog	2.98914197
8	MP0003111_abnormal_nucleus_morphology	2.62544388
9	MP0005451_abnormal_body_composition	2.36453820
10	MP0009840_abnormal_foam_cell	2.34049917
11	MP0004957_abnormal_blastocyst_morpholog	2.20510406
12	MP0005174_abnormal_tail_pigmentation	2.17106592
13	MP0001348_abnormal_lacrimal_gland	2.12611713
14	MP0003077_abnormal_cell_cycle	2.05439452
15	MP0003786_premature_aging	1.97426263
16	MP0002168_other_aberrant_phenotype	1.85347027
17	MP0000747_muscle_weakness	1.80841392
18	MP0003172_abnormal_lysosome_physiology	1.78901572
19	MP0008058_abnormal_DNA_repair	1.76171108
20	MP0004043_abnormal_pH_regulation	1.74995571
21	MP0005395_other_phenotype	1.61808039
22	MP0008057_abnormal_DNA_replication	1.61534078
23	MP0010307_abnormal_tumor_latency	1.59413929
24	MP0005408_hypopigmentation	1.55290942
25	MP0000350_abnormal_cell_proliferation	1.43750823
26	MP0002210_abnormal_sex_determination	1.42070763
27	MP0001663_abnormal_digestive_system	1.41301701
28	MP0004147_increased_porphyrin_level	1.41198249
29	MP0000372_irregular_coat_pigmentation	1.35224694
30	MP0008932_abnormal_embryonic_tissue	1.34287079
31	MP0005083_abnormal_biliary_tract	1.32734376
32	MP0001730_embryonic_growth_arrest	1.32305748
33	MP0001145_abnormal_male_reproductive	1.30719274
34	MP0004808_abnormal_hematopoietic_stem	1.27537256
35	MP0010094_abnormal_chromosome_stability	1.27183762
36	MP0005220_abnormal_exocrine_pancreas	1.26239523
37	MP0003656_abnormal_erythrocyte_physiolo	1.26039843
38	MP0003763_abnormal_thymus_physiology	1.24675536
39	MP0005671_abnormal_response_to	1.24482413
40	MP0001929_abnormal_gametogenesis	1.22601663
41	MP0003718_maternal_effect	1.21536008
42	MP0002075_abnormal_coat/hair_pigmentati	1.16032125
43	MP0003698_abnormal_male_reproductive	1.11711480
44	MP0002095_abnormal_skin_pigmentation	1.10802692
45	MP0000313_abnormal_cell_death	1.09057184
46	MP0001661_extended_life_span	1.08838612
47	MP0001186_pigmentation_phenotype	1.08688248
48	MP0005381_digestive/alimentary_phenotyp	1.07492773
49	MP0003183_abnormal_peptide_metabolism	1.06804204
50	MP0000689_abnormal_spleen_morphology	1.06691472
51	MP0000358_abnormal_cell_content/	1.03143041
52	MP0002080_prenatal_lethality	1.02867379
53	MP0002398_abnormal_bone_marrow	1.01467229
54	MP0000653_abnormal_sex_gland	1.01176170
55	MP0001188_hyperpigmentation	1.00970926
56	MP0008569_lethality_at_weaning	0.93957948
57	MP0002429_abnormal_blood_cell	0.93720313
58	MP0008007_abnormal_cellular_replicative	0.92568151
59	MP0001697_abnormal_embryo_size	0.92372326
60	MP0002090_abnormal_vision	0.91820758
61	MP0003959_abnormal_lean_body	0.91452981
62	MP0001324_abnormal_eye_pigmentation	0.90738796
63	MP0009672_abnormal_birth_weight	0.88899158
64	MP0005075_abnormal_melanosome_morpholog	0.88085624
65	MP0002396_abnormal_hematopoietic_system	0.88044064
66	MP0000703_abnormal_thymus_morphology	0.85872882
67	MP0005464_abnormal_platelet_physiology	0.85149324
68	MP0003045_fibrosis	0.85054747
69	MP0000685_abnormal_immune_system	0.84774534
70	MP0006035_abnormal_mitochondrial_morpho	0.84685483
71	MP0001919_abnormal_reproductive_system	0.82245483
72	MP0002722_abnormal_immune_system	0.80236079
73	MP0000716_abnormal_immune_system	0.79731994
74	MP0005670_abnormal_white_adipose	0.78140546
75	MP0010234_abnormal_vibrissa_follicle	0.76697268
76	MP0000465_gastrointestinal_hemorrhage	0.76606422
77	MP0004233_abnormal_muscle_weight	0.76088754
78	MP0005384_cellular_phenotype	0.75799923
79	MP0002877_abnormal_melanocyte_morpholog	0.74300605
80	MP0005621_abnormal_cell_physiology	0.73800515
81	MP0000598_abnormal_liver_morphology	0.72985607
82	MP0002019_abnormal_tumor_incidence	0.72394899
83	MP0002751_abnormal_autonomic_nervous	0.71785018
84	MP0000371_diluted_coat_color	0.71299878
85	MP0003221_abnormal_cardiomyocyte_apopto	0.69292302
86	MP0002161_abnormal_fertility/fecundity	0.66153026
87	MP0001800_abnormal_humoral_immune	0.65494440
88	MP0009643_abnormal_urine_homeostasis	0.63799548
89	MP0000609_abnormal_liver_physiology	0.59612902
90	MP0009785_altered_susceptibility_to	0.58399562
91	MP0003943_abnormal_hepatobiliary_system	0.57690218
92	MP0002269_muscular_atrophy	0.55286709
93	MP0006036_abnormal_mitochondrial_physio	0.55244997
94	MP0001270_distended_abdomen	0.52768402
95	MP0002229_neurodegeneration	0.52603805
96	MP0004145_abnormal_muscle_electrophysio	0.52057106
97	MP0002084_abnormal_developmental_patter	0.51349056
98	MP0001944_abnormal_pancreas_morphology	0.51275594
99	MP0001666_abnormal_nutrient_absorption	0.51012075
100	MP0002086_abnormal_extraembryonic_tissu	0.50512190

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.63751661
2	Increased cerebral lipofuscin (HP:0011813)	4.50774814
3	Back pain (HP:0003418)	4.30550646
4	Vacuolated lymphocytes (HP:0001922)	4.01560739
5	Nonimmune hydrops fetalis (HP:0001790)	3.86446891
6	Albinism (HP:0001022)	3.77923327
7	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.74517355
8	Patchy hypopigmentation of hair (HP:0011365)	3.68361320
9	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.66540362
10	Large for gestational age (HP:0001520)	3.62183847
11	Decreased circulating renin level (HP:0003351)	3.51505848
12	Abnormal number of erythroid precursors (HP:0012131)	3.45864342
13	Abnormality of liposaccharide metabolism (HP:0010968)	3.45657247
14	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.45657247
15	Abnormality of glycolipid metabolism (HP:0010969)	3.45657247
16	Hyperactive renin-angiotensin system (HP:0000841)	3.42989619
17	Hypoplasia of the uterus (HP:0000013)	3.26738666
18	Short middle phalanx of the 5th finger (HP:0004220)	3.24100146
19	Carpal bone hypoplasia (HP:0001498)	3.20551054
20	Abnormality of cells of the erythroid lineage (HP:0012130)	3.19942208
21	Vertebral compression fractures (HP:0002953)	3.17655486
22	White forelock (HP:0002211)	3.11040764
23	Upper limb muscle weakness (HP:0003484)	3.08025719
24	Reticulocytopenia (HP:0001896)	2.99956656
25	Spastic paraparesis (HP:0002313)	2.98146795
26	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.92888436
27	Overlapping toe (HP:0001845)	2.88739449
28	Dysostosis multiplex (HP:0000943)	2.85669550
29	Global brain atrophy (HP:0002283)	2.83476833
30	Abnormality of the distal phalanges of the toes (HP:0010182)	2.83043273
31	Acute hepatic failure (HP:0006554)	2.82351909
32	Urethral obstruction (HP:0000796)	2.79466188
33	Abnormal auditory evoked potentials (HP:0006958)	2.75805637
34	Abnormal tarsal ossification (HP:0008369)	2.75474806
35	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.64629273
36	Abnormal gallbladder physiology (HP:0012438)	2.61502615
37	Cholecystitis (HP:0001082)	2.61502615
38	Basal cell carcinoma (HP:0002671)	2.56943720
39	Polycythemia (HP:0001901)	2.54760677
40	Tetraparesis (HP:0002273)	2.52379361
41	Abnormality of reticulocytes (HP:0004312)	2.51954373
42	Spinal cord lesions (HP:0100561)	2.50136950
43	Syringomyelia (HP:0003396)	2.50136950
44	Ankyloglossia (HP:0010296)	2.45491003
45	Aplasia/hypoplasia of the uterus (HP:0008684)	2.43738888
46	Ridged nail (HP:0001807)	2.42254235
47	Cutaneous melanoma (HP:0012056)	2.40017631
48	Onycholysis (HP:0001806)	2.39605173
49	Microretrognathia (HP:0000308)	2.38285944
50	Dry hair (HP:0011359)	2.37748077
51	Long palpebral fissure (HP:0000637)	2.36756435
52	Hyponatremia (HP:0002902)	2.34226774
53	Abnormality of incisor morphology (HP:0011063)	2.33866919
54	Small epiphyses (HP:0010585)	2.33615431
55	Abnormal protein glycosylation (HP:0012346)	2.32696188
56	Abnormal glycosylation (HP:0012345)	2.32696188
57	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.32696188
58	Abnormal protein N-linked glycosylation (HP:0012347)	2.32696188
59	Deep palmar crease (HP:0006191)	2.31738596
60	Reticulocytosis (HP:0001923)	2.29216449
61	Hypercortisolism (HP:0001578)	2.28730176
62	Gonadal dysgenesis (HP:0000133)	2.22258481
63	Hypokalemic alkalosis (HP:0001949)	2.21072603
64	Hypopigmentation of the fundus (HP:0007894)	2.20130259
65	Squamous cell carcinoma (HP:0002860)	2.16974717
66	Unilateral renal agenesis (HP:0000122)	2.16235868
67	Exocrine pancreatic insufficiency (HP:0001738)	2.14673251
68	Visual hallucinations (HP:0002367)	2.12667419
69	Type I transferrin isoform profile (HP:0003642)	2.10597571
70	Hyperbilirubinemia (HP:0002904)	2.08697054
71	Self-mutilation (HP:0000742)	2.08662050
72	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.06698016
73	Impulsivity (HP:0100710)	2.05912603
74	Thoracolumbar scoliosis (HP:0002944)	2.04637593
75	Hypokinesia (HP:0002375)	1.99591087
76	Chronic bronchitis (HP:0004469)	1.99178775
77	Abnormality of oral frenula (HP:0000190)	1.97651190
78	Pallor (HP:0000980)	1.96857396
79	Abnormality of the lumbar spine (HP:0100712)	1.96324656
80	Chronic mucocutaneous candidiasis (HP:0002728)	1.95318423
81	Recurrent cutaneous fungal infections (HP:0011370)	1.95318423
82	Hyperkalemia (HP:0002153)	1.93918614
83	Premature graying of hair (HP:0002216)	1.93837009
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93301105
85	Exercise-induced myalgia (HP:0003738)	1.91008407
86	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.89128915
87	Deformed sella turcica (HP:0002681)	1.88804803
88	Paraparesis (HP:0002385)	1.88631670
89	Birth length less than 3rd percentile (HP:0003561)	1.88344762
90	Long eyelashes (HP:0000527)	1.84250818
91	CNS hypomyelination (HP:0003429)	1.83272858
92	Abnormal autonomic nervous system physiology (HP:0012332)	1.82862641
93	Erythema (HP:0010783)	1.82788583
94	Autoimmune hemolytic anemia (HP:0001890)	1.81117690
95	J-shaped sella turcica (HP:0002680)	1.80361546
96	Breast hypoplasia (HP:0003187)	1.79562706
97	Macrocytic anemia (HP:0001972)	1.78696910
98	Abnormal foot bone ossification (HP:0010675)	1.77328951
99	Death in infancy (HP:0001522)	1.75870771
100	Lower limb hyperreflexia (HP:0002395)	1.75064252

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	6.98631189
2	EIF2AK3	4.19812540
3	CDC7	3.57140226
4	TAOK2	3.54827852
5	TAF1	3.15862016
6	KSR2	2.97440007
7	IRAK3	2.85004654
8	ARAF	2.80885107
9	NME2	2.75782284
10	ERN1	2.71758008
11	BRAF	2.60454388
12	CDK19	2.51521970
13	MAP3K9	2.48953544
14	ITK	2.20371874
15	SCYL2	2.14977171
16	EEF2K	2.02231619
17	TESK2	1.71255897
18	MAP3K13	1.61853874
19	CDK3	1.57575401
20	RPS6KB2	1.57532557
21	RAF1	1.52009088
22	TTK	1.45142961
23	NME1	1.44677585
24	STK16	1.41726555
25	KSR1	1.26553928
26	MAPK7	1.24292229
27	MAP3K8	1.18824634
28	BUB1	1.15690402
29	BRSK1	1.14261577
30	CDK8	1.11600696
31	JAK2	1.07895206
32	ICK	0.99147486
33	LRRK2	0.96198777
34	STK10	0.95617290
35	SIK1	0.91379247
36	MARK3	0.89095640
37	MUSK	0.88241409
38	MAP3K1	0.86879915
39	MAP3K10	0.85449697
40	RPS6KB1	0.84833229
41	WEE1	0.82639636
42	PAK2	0.79477155
43	MOS	0.78469532
44	AKT2	0.78060401
45	IRAK2	0.76052399
46	MAPK12	0.73088297
47	JAK1	0.72620154
48	CDK7	0.71502356
49	GRK6	0.68134164
50	CHEK1	0.66430529
51	RPS6KC1	0.66097290
52	RPS6KL1	0.66097290
53	SRPK1	0.61880228
54	TSSK6	0.61251094
55	ALK	0.60322405
56	IRAK4	0.58137617
57	PIM1	0.58104133
58	MAP3K14	0.56093136
59	CDK11A	0.55895849
60	RPS6KA6	0.54334697
61	CSNK2A1	0.53512046
62	AURKA	0.50914733
63	MARK2	0.50088554
64	MAP3K2	0.49810834
65	CHEK2	0.49026132
66	CDK14	0.48750232
67	PAK1	0.47278337
68	ATR	0.43025724
69	PDPK1	0.42562765
70	MATK	0.42286503
71	PLK1	0.41528251
72	JAK3	0.41016472
73	TBK1	0.40612658
74	PRKCI	0.40309246
75	CDK15	0.38705430
76	MAP2K2	0.38349575
77	MAP4K1	0.38092991
78	DYRK1B	0.37362210
79	CDK2	0.36773718
80	NEK1	0.35685795
81	CCNB1	0.35544975
82	EIF2AK1	0.34283450
83	PBK	0.34189228
84	CDK18	0.33057359
85	MST4	0.32624888
86	TYK2	0.32575238
87	INSRR	0.31895652
88	PDK1	0.31749317
89	IRAK1	0.31126528
90	RPS6KA1	0.30085444
91	CDK1	0.29697591
92	MAP2K1	0.27637771
93	CSF1R	0.27449112
94	PLK3	0.26414741
95	CSNK2A2	0.24149142
96	ATM	0.23968238
97	ACVR1B	0.23768857
98	AKT1	0.21972145
99	DAPK2	0.21893076
100	AURKB	0.19890471

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	N-Glycan biosynthesis_Homo sapiens_hsa00510	4.77402289
2	Ribosome_Homo sapiens_hsa03010	3.46362867
3	DNA replication_Homo sapiens_hsa03030	3.30280549
4	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	3.05623826
5	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	3.02615658
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.00911827
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.88209849
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.69758215
9	One carbon pool by folate_Homo sapiens_hsa00670	2.37472560
10	Proteasome_Homo sapiens_hsa03050	2.08327416
11	mRNA surveillance pathway_Homo sapiens_hsa03015	2.03288156
12	Mismatch repair_Homo sapiens_hsa03430	2.01259619
13	RNA transport_Homo sapiens_hsa03013	1.99547636
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.92036896
15	Bladder cancer_Homo sapiens_hsa05219	1.90803303
16	Acute myeloid leukemia_Homo sapiens_hsa05221	1.87453779
17	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.82097914
18	Base excision repair_Homo sapiens_hsa03410	1.76573853
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.74135274
20	Non-small cell lung cancer_Homo sapiens_hsa05223	1.51476293
21	Cell cycle_Homo sapiens_hsa04110	1.51441977
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47892513
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.44050078
24	Protein export_Homo sapiens_hsa03060	1.40101918
25	Vibrio cholerae infection_Homo sapiens_hsa05110	1.37984373
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.33988395
27	Other glycan degradation_Homo sapiens_hsa00511	1.33718309
28	Lysosome_Homo sapiens_hsa04142	1.29044161
29	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.24852438
30	Fatty acid elongation_Homo sapiens_hsa00062	1.18142086
31	Spliceosome_Homo sapiens_hsa03040	1.17449787
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16344659
33	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.15742258
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15607725
35	Endometrial cancer_Homo sapiens_hsa05213	1.04936480
36	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.02073924
37	Thyroid cancer_Homo sapiens_hsa05216	1.01918438
38	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.95618203
39	Prion diseases_Homo sapiens_hsa05020	0.94592019
40	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.94379561
41	Prostate cancer_Homo sapiens_hsa05215	0.93405841
42	Pancreatic cancer_Homo sapiens_hsa05212	0.91441367
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.91365941
44	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.90229594
45	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.89426366
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.88045341
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87140491
48	Basal transcription factors_Homo sapiens_hsa03022	0.85563408
49	Hepatitis B_Homo sapiens_hsa05161	0.85535385
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.84858765
51	Sulfur relay system_Homo sapiens_hsa04122	0.84768423
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.83305369
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81097871
54	Herpes simplex infection_Homo sapiens_hsa05168	0.80781501
55	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.78624803
56	Glioma_Homo sapiens_hsa05214	0.77703620
57	Measles_Homo sapiens_hsa05162	0.75876856
58	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.73357435
59	Parkinsons disease_Homo sapiens_hsa05012	0.72879594
60	RNA polymerase_Homo sapiens_hsa03020	0.72204339
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.69111389
62	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.68819450
63	Influenza A_Homo sapiens_hsa05164	0.67891057
64	Purine metabolism_Homo sapiens_hsa00230	0.67163772
65	Folate biosynthesis_Homo sapiens_hsa00790	0.64903123
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63513042
67	Melanoma_Homo sapiens_hsa05218	0.58911585
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58355879
69	Insulin signaling pathway_Homo sapiens_hsa04910	0.57521938
70	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.56350237
71	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.54460374
72	HTLV-I infection_Homo sapiens_hsa05166	0.54413701
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53666468
74	mTOR signaling pathway_Homo sapiens_hsa04150	0.53483738
75	FoxO signaling pathway_Homo sapiens_hsa04068	0.53262370
76	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.52038853
77	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.48144609
78	Sulfur metabolism_Homo sapiens_hsa00920	0.47653408
79	Carbon metabolism_Homo sapiens_hsa01200	0.44755520
80	Fanconi anemia pathway_Homo sapiens_hsa03460	0.44446363
81	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.43033924
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42395078
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42305121
84	Apoptosis_Homo sapiens_hsa04210	0.39709079
85	Oocyte meiosis_Homo sapiens_hsa04114	0.39385598
86	Renal cell carcinoma_Homo sapiens_hsa05211	0.38645635
87	Homologous recombination_Homo sapiens_hsa03440	0.38518314
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36919096
89	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36552638
90	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34690803
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34602099
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.34369529
93	Huntingtons disease_Homo sapiens_hsa05016	0.34101431
94	ErbB signaling pathway_Homo sapiens_hsa04012	0.30931278
95	Allograft rejection_Homo sapiens_hsa05330	0.30590190
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.29958109
97	RNA degradation_Homo sapiens_hsa03018	0.29643033
98	Viral carcinogenesis_Homo sapiens_hsa05203	0.28727598
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.28612215
100	Metabolic pathways_Homo sapiens_hsa01100	0.28610227

TSPY9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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