TSPYL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.18140664
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.96830574
3locomotory exploration behavior (GO:0035641)5.59705038
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57504813
5synaptic vesicle exocytosis (GO:0016079)4.87670978
6regulation of synaptic vesicle exocytosis (GO:2000300)4.87412472
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.70355550
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.62357570
9glutamate secretion (GO:0014047)4.53214981
10L-amino acid import (GO:0043092)4.40267507
11vocalization behavior (GO:0071625)4.36852249
12cerebellar granule cell differentiation (GO:0021707)4.35793867
13neurotransmitter secretion (GO:0007269)4.35658691
14regulation of synaptic vesicle transport (GO:1902803)4.28702418
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.21434368
16layer formation in cerebral cortex (GO:0021819)4.21311430
17regulation of glutamate receptor signaling pathway (GO:1900449)4.12515713
18sodium ion export (GO:0071436)4.10689748
19amino acid import (GO:0043090)4.05369495
20exploration behavior (GO:0035640)4.04666919
21regulation of neuronal synaptic plasticity (GO:0048168)3.99281314
22cellular potassium ion homeostasis (GO:0030007)3.97689709
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.93359438
24proline transport (GO:0015824)3.85089175
25neuromuscular process controlling posture (GO:0050884)3.82550898
26regulation of synapse structural plasticity (GO:0051823)3.81365939
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80706195
28activation of protein kinase A activity (GO:0034199)3.80099495
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76221736
30neuronal action potential propagation (GO:0019227)3.76202105
31cerebellar Purkinje cell differentiation (GO:0021702)3.71206241
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.66148544
33cerebellar Purkinje cell layer development (GO:0021680)3.65397346
34gamma-aminobutyric acid transport (GO:0015812)3.62407731
35protein localization to synapse (GO:0035418)3.60366669
36regulation of synapse maturation (GO:0090128)3.59007160
37cell communication by electrical coupling (GO:0010644)3.58699692
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53065552
39glycine transport (GO:0015816)3.52586847
40regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52553449
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49593878
42synaptic transmission, glutamatergic (GO:0035249)3.44754936
43neurotransmitter transport (GO:0006836)3.43969666
44synaptic vesicle endocytosis (GO:0048488)3.42706249
45neuron cell-cell adhesion (GO:0007158)3.40917239
46dendritic spine morphogenesis (GO:0060997)3.40231959
47negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36988782
48neuromuscular process controlling balance (GO:0050885)3.34303984
49positive regulation of Rap GTPase activity (GO:0032854)3.33479411
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33083144
51long-term memory (GO:0007616)3.32459534
52regulation of voltage-gated calcium channel activity (GO:1901385)3.31823141
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31705753
54regulation of ARF protein signal transduction (GO:0032012)3.31335711
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31291145
56vesicle transport along microtubule (GO:0047496)3.28520055
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.24278574
58neuron-neuron synaptic transmission (GO:0007270)3.23254003
59regulation of neurotransmitter levels (GO:0001505)3.19366586
60regulation of clathrin-mediated endocytosis (GO:2000369)3.18150856
61neuronal ion channel clustering (GO:0045161)3.14996045
62mating behavior (GO:0007617)3.11445530
63cellular sodium ion homeostasis (GO:0006883)3.10554298
64positive regulation of membrane potential (GO:0045838)3.09368841
65positive regulation of dendritic spine development (GO:0060999)3.07512613
66potassium ion import (GO:0010107)3.05950245
67prepulse inhibition (GO:0060134)3.05790649
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04035082
69central nervous system myelination (GO:0022010)3.03457996
70axon ensheathment in central nervous system (GO:0032291)3.03457996
71regulation of Rap GTPase activity (GO:0032317)3.03301042
72glutamate receptor signaling pathway (GO:0007215)3.03214609
73dendrite morphogenesis (GO:0048813)3.03050500
74regulation of synaptic plasticity (GO:0048167)3.01256924
75regulation of neurotransmitter secretion (GO:0046928)3.00974384
76membrane depolarization during action potential (GO:0086010)3.00256183
77positive regulation of neurotransmitter secretion (GO:0001956)3.00252241
78potassium ion homeostasis (GO:0055075)3.00209465
79regulation of vesicle fusion (GO:0031338)2.97219976
80regulation of postsynaptic membrane potential (GO:0060078)2.95544144
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94939937
82innervation (GO:0060384)2.91669922
83positive regulation of synapse maturation (GO:0090129)2.89956248
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88756677
85cell differentiation in hindbrain (GO:0021533)2.88681225
86neurotransmitter-gated ion channel clustering (GO:0072578)2.87814363
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87409727
88auditory behavior (GO:0031223)2.87347973
89negative regulation of dendrite morphogenesis (GO:0050774)2.86626951
90positive regulation of neurotransmitter transport (GO:0051590)2.85582789
91suckling behavior (GO:0001967)2.85456992
92regulation of neurotransmitter transport (GO:0051588)2.85019902
93response to auditory stimulus (GO:0010996)2.84998316
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84339916
95negative regulation of inclusion body assembly (GO:0090084)2.82823550
96regulation of calcium ion-dependent exocytosis (GO:0017158)2.82134175
97chemosensory behavior (GO:0007635)2.81946660
98transmission of nerve impulse (GO:0019226)2.81377993
99response to pheromone (GO:0019236)2.81088278
100membrane hyperpolarization (GO:0060081)2.79199162
101dendritic spine organization (GO:0097061)2.78110346
102neuromuscular process (GO:0050905)2.76592442
103regulation of synaptic transmission (GO:0050804)2.75467871
104vesicle docking involved in exocytosis (GO:0006904)2.75409156
105organelle transport along microtubule (GO:0072384)2.75213077
106long-term synaptic potentiation (GO:0060291)2.74811826
107axon cargo transport (GO:0008088)2.74512295
108establishment of nucleus localization (GO:0040023)2.74340119
109detection of calcium ion (GO:0005513)2.71022503
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70535813
111signal release (GO:0023061)2.70441326
112neuron recognition (GO:0008038)2.69185799
113regulation of synaptic transmission, GABAergic (GO:0032228)2.68450549
114social behavior (GO:0035176)2.68309064
115intraspecies interaction between organisms (GO:0051703)2.68309064
116membrane repolarization (GO:0086009)2.67271456
117membrane depolarization (GO:0051899)2.66429619
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.65991549
119positive regulation of synaptic transmission (GO:0050806)2.64164900
120postsynaptic membrane organization (GO:0001941)2.63598586
121regulation of synaptic transmission, glutamatergic (GO:0051966)2.63523482
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.63507518
123neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.63489243
124negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61832773
125regulation of exocytosis (GO:0017157)2.57006112
126peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.56649379
127acidic amino acid transport (GO:0015800)2.54570677
128regulation of dendritic spine morphogenesis (GO:0061001)2.49692574
129signal complex assembly (GO:0007172)2.49186437
130regulation of ARF GTPase activity (GO:0032312)2.49119957
131regulation of dendritic spine development (GO:0060998)2.46564439
132response to gravity (GO:0009629)2.45966729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38440388
2* RARB_27405468_Chip-Seq_BRAIN_Mouse2.97333946
3DROSHA_22980978_ChIP-Seq_HELA_Human2.85398789
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71720419
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69358306
6REST_21632747_ChIP-Seq_MESCs_Mouse2.68734127
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.66458079
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53850499
9GBX2_23144817_ChIP-Seq_PC3_Human2.49438016
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48665250
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45350048
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45350048
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40735104
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38623016
15* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35947803
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34365155
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.30709000
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22166442
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17530738
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09688508
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.07313884
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06555386
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.06251048
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.05301114
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05106153
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99916609
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95249442
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93198139
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86595688
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.80780323
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80642012
32TCF7_22412390_ChIP-Seq_EML_Mouse1.77726357
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71283491
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66844306
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65635204
36KDM2B_26808549_Chip-Seq_K562_Human1.65303485
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58200912
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.57537319
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57420662
40ZNF274_21170338_ChIP-Seq_K562_Hela1.56817586
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54920895
42* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53369628
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.52185504
44* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49966231
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48212068
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45352855
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42636826
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40326321
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38998509
50AR_21572438_ChIP-Seq_LNCaP_Human1.37636289
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35618827
52SMAD4_21799915_ChIP-Seq_A2780_Human1.33968593
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33766179
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33206872
55AR_19668381_ChIP-Seq_PC3_Human1.32476821
56RUNX_20019798_ChIP-Seq_JUKART_Human1.29518096
57MYC_22102868_ChIP-Seq_BL_Human1.26689960
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.26686354
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.26340877
60* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26075365
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23791892
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22038367
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21351557
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18876905
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18376739
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18087713
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17591730
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16366099
69STAT3_23295773_ChIP-Seq_U87_Human1.15693082
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14694408
71P68_20966046_ChIP-Seq_HELA_Human1.12542933
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.11629292
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11537298
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10192751
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09861101
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09729748
77KDM2B_26808549_Chip-Seq_DND41_Human1.09502845
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08381882
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06230564
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.05767511
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.05142609
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.03092632
83* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02126698
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.01550003
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00898131
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99876674
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99706217
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98846033
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98495167
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98166697
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.98077462
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96810623
93CTCF_27219007_Chip-Seq_Bcells_Human0.95256927
94TCF4_23295773_ChIP-Seq_U87_Human0.95042287
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94781766
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94116117
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93991549
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.93816955
99KLF4_19829295_ChIP-Seq_ESCs_Human0.93809107
100MAF_26560356_Chip-Seq_TH2_Human0.93781392
101AHR_22903824_ChIP-Seq_MCF-7_Human0.92638012
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92323239
103* DPY_21335234_ChIP-Seq_ESCs_Mouse0.90869981
104CREB1_26743006_Chip-Seq_LNCaP_Human0.90499965
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.90235106
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.90229892
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89617771
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89466894
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89170013
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88795792
111SMC4_20622854_ChIP-Seq_HELA_Human0.88795242
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88506028
113AR_25329375_ChIP-Seq_VCAP_Human0.88288784
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87771300
115LXR_22292898_ChIP-Seq_THP-1_Human0.87688275
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86714113
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85642193
118* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85281383
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84855087
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83925698
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83172470
122RACK7_27058665_Chip-Seq_MCF-7_Human0.83143077
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.82653746
124IGF1R_20145208_ChIP-Seq_DFB_Human0.81518927
125RXR_22108803_ChIP-Seq_LS180_Human0.81196695
126TP53_23651856_ChIP-Seq_MEFs_Mouse0.80567956
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.80512381
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80461132
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80117038
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79747390
131* OCT4_19829295_ChIP-Seq_ESCs_Human0.78331601
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.76781844
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75696185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.88455106
2MP0003635_abnormal_synaptic_transmissio3.75577255
3MP0003880_abnormal_central_pattern3.35043249
4MP0004270_analgesia3.10518487
5MP0009745_abnormal_behavioral_response2.88848200
6MP0002064_seizures2.83596223
7MP0009046_muscle_twitch2.81469741
8MP0002063_abnormal_learning/memory/cond2.81415656
9MP0002909_abnormal_adrenal_gland2.76345561
10MP0009780_abnormal_chondrocyte_physiolo2.76179657
11MP0005423_abnormal_somatic_nervous2.69321146
12MP0003122_maternal_imprinting2.68927040
13MP0002572_abnormal_emotion/affect_behav2.43991429
14MP0003283_abnormal_digestive_organ2.39179911
15MP0002822_catalepsy2.37858835
16MP0003787_abnormal_imprinting2.25844048
17MP0002272_abnormal_nervous_system2.23801522
18MP0001968_abnormal_touch/_nociception2.16194561
19MP0002734_abnormal_mechanical_nocicepti2.14033633
20MP0001348_abnormal_lacrimal_gland2.12183849
21MP0001486_abnormal_startle_reflex2.12066633
22MP0000569_abnormal_digit_pigmentation2.11231738
23MP0005646_abnormal_pituitary_gland1.95364192
24MP0001501_abnormal_sleep_pattern1.94564141
25MP0005645_abnormal_hypothalamus_physiol1.89621391
26MP0008569_lethality_at_weaning1.88392553
27MP0000013_abnormal_adipose_tissue1.88356104
28MP0002733_abnormal_thermal_nociception1.87716056
29MP0004885_abnormal_endolymph1.87672522
30MP0004858_abnormal_nervous_system1.86911003
31MP0001440_abnormal_grooming_behavior1.76727097
32MP0004811_abnormal_neuron_physiology1.73061823
33MP0008961_abnormal_basal_metabolism1.71229535
34MP0001970_abnormal_pain_threshold1.69977904
35MP0002557_abnormal_social/conspecific_i1.67299038
36MP0002067_abnormal_sensory_capabilities1.65501150
37MP0003329_amyloid_beta_deposits1.60360538
38MP0002184_abnormal_innervation1.58804488
39MP0000920_abnormal_myelination1.57447274
40MP0000955_abnormal_spinal_cord1.55365586
41MP0004510_myositis1.53286333
42MP0003879_abnormal_hair_cell1.47949223
43MP0004924_abnormal_behavior1.47609308
44MP0005386_behavior/neurological_phenoty1.47609308
45MP0006276_abnormal_autonomic_nervous1.40352701
46MP0001502_abnormal_circadian_rhythm1.38922881
47MP0003763_abnormal_thymus_physiology1.35382607
48MP0000778_abnormal_nervous_system1.33075380
49MP0002882_abnormal_neuron_morphology1.31427410
50MP0000751_myopathy1.30941746
51MP0002066_abnormal_motor_capabilities/c1.30468345
52MP0004145_abnormal_muscle_electrophysio1.29363603
53MP0003172_abnormal_lysosome_physiology1.28919273
54MP0002735_abnormal_chemical_nociception1.27581918
55MP0002736_abnormal_nociception_after1.26342266
56MP0003633_abnormal_nervous_system1.23888240
57MP0004043_abnormal_pH_regulation1.21761587
58MP0003045_fibrosis1.20638553
59MP0001984_abnormal_olfaction1.11353484
60MP0003121_genomic_imprinting1.11197116
61MP0000604_amyloidosis1.10031933
62MP0001299_abnormal_eye_distance/1.08452909
63MP0000003_abnormal_adipose_tissue1.05720815
64MP0000631_abnormal_neuroendocrine_gland1.05345579
65MP0002152_abnormal_brain_morphology1.04631512
66MP0004233_abnormal_muscle_weight1.04093700
67MP0010386_abnormal_urinary_bladder1.02292722
68MP0003123_paternal_imprinting1.02186948
69MP0006072_abnormal_retinal_apoptosis1.00588351
70MP0004130_abnormal_muscle_cell0.98550369
71MP0004142_abnormal_muscle_tone0.98185260
72MP0002229_neurodegeneration0.97476941
73MP0002069_abnormal_eating/drinking_beha0.96339497
74MP0003631_nervous_system_phenotype0.95873361
75MP0003183_abnormal_peptide_metabolism0.95104981
76MP0002837_dystrophic_cardiac_calcinosis0.93989441
77MP0002009_preneoplasia0.92870244
78MP0003634_abnormal_glial_cell0.92631287
79MP0001177_atelectasis0.91037355
80MP0001963_abnormal_hearing_physiology0.88167958
81MP0002653_abnormal_ependyma_morphology0.88013650
82MP0008877_abnormal_DNA_methylation0.87746649
83MP0002877_abnormal_melanocyte_morpholog0.85799781
84MP0008995_early_reproductive_senescence0.82530673
85MP0004085_abnormal_heartbeat0.82041642
86MP0003690_abnormal_glial_cell0.79848518
87MP0001986_abnormal_taste_sensitivity0.79489981
88MP0005623_abnormal_meninges_morphology0.77114501
89MP0001905_abnormal_dopamine_level0.76415296
90MP0003436_decreased_susceptibility_to0.76406582
91MP0001944_abnormal_pancreas_morphology0.75892092
92MP0005535_abnormal_body_temperature0.75756700
93MP0000639_abnormal_adrenal_gland0.75340079
94MP0002638_abnormal_pupillary_reflex0.74913329
95MP0001529_abnormal_vocalization0.74204228
96MP0003632_abnormal_nervous_system0.71846484
97MP0008872_abnormal_physiological_respon0.69945943
98MP0008874_decreased_physiological_sensi0.69585742
99MP0002090_abnormal_vision0.69562318
100MP0002234_abnormal_pharynx_morphology0.69530840
101MP0005551_abnormal_eye_electrophysiolog0.68897421
102MP0001346_abnormal_lacrimal_gland0.68413252
103MP0000747_muscle_weakness0.68166953
104MP0001851_eye_inflammation0.66407725
105MP0005499_abnormal_olfactory_system0.65462088
106MP0005394_taste/olfaction_phenotype0.65462088
107MP0002693_abnormal_pancreas_physiology0.64806087
108MP0000534_abnormal_ureter_morphology0.63092755
109MP0001853_heart_inflammation0.62847427
110MP0004947_skin_inflammation0.62058904
111MP0005375_adipose_tissue_phenotype0.62011308
112MP0004742_abnormal_vestibular_system0.60861798
113MP0010769_abnormal_survival0.60850852
114MP0005167_abnormal_blood-brain_barrier0.60367265
115MP0010768_mortality/aging0.59915635
116MP0003137_abnormal_impulse_conducting0.59639420
117MP0002078_abnormal_glucose_homeostasis0.59601566
118MP0009278_abnormal_bone_marrow0.59137224
119MP0005409_darkened_coat_color0.59039901
120MP0005000_abnormal_immune_tolerance0.58931160
121MP0003075_altered_response_to0.58784363
122MP0002083_premature_death0.57479292
123MP0001765_abnormal_ion_homeostasis0.55943432
124MP0002249_abnormal_larynx_morphology0.55534933
125MP0005166_decreased_susceptibility_to0.55272540
126MP0002082_postnatal_lethality0.54234472
127MP0010770_preweaning_lethality0.54234472
128MP0002089_abnormal_postnatal_growth/wei0.53302497
129MP0002933_joint_inflammation0.52966974
130MP0003866_abnormal_defecation0.52847648
131MP0002133_abnormal_respiratory_system0.52103690
132MP0005388_respiratory_system_phenotype0.52103690

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.36861379
2Obstructive sleep apnea (HP:0002870)5.16570659
3Myokymia (HP:0002411)5.05185142
4Visual hallucinations (HP:0002367)4.92465150
5Focal seizures (HP:0007359)4.53037557
6Ankle clonus (HP:0011448)3.82680716
7Action tremor (HP:0002345)3.82477263
8Neurofibrillary tangles (HP:0002185)3.73351797
9Supranuclear gaze palsy (HP:0000605)3.51415116
10Progressive cerebellar ataxia (HP:0002073)3.50064398
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.36289248
12Epileptic encephalopathy (HP:0200134)3.32734566
13Absence seizures (HP:0002121)3.31561388
14Atonic seizures (HP:0010819)3.27847683
15Depression (HP:0000716)3.24893026
16Papilledema (HP:0001085)3.14923191
17Peripheral hypomyelination (HP:0007182)3.11126521
18Generalized tonic-clonic seizures (HP:0002069)3.09471864
19Febrile seizures (HP:0002373)2.99793107
20Postural instability (HP:0002172)2.96316193
21Slow saccadic eye movements (HP:0000514)2.95671314
22Tetraplegia (HP:0002445)2.93397749
23Abnormality of the lower motor neuron (HP:0002366)2.90422193
24Genetic anticipation (HP:0003743)2.89925656
25Dialeptic seizures (HP:0011146)2.87032818
26Impaired vibration sensation in the lower limbs (HP:0002166)2.80778697
27Urinary bladder sphincter dysfunction (HP:0002839)2.75661946
28Sleep apnea (HP:0010535)2.74230282
29Macroorchidism (HP:0000053)2.67675090
30Truncal ataxia (HP:0002078)2.67142376
31Poor eye contact (HP:0000817)2.65553296
32Failure to thrive in infancy (HP:0001531)2.65377154
33Agitation (HP:0000713)2.64394184
34Neoplasm of the heart (HP:0100544)2.63794528
35Insomnia (HP:0100785)2.60259566
36Anxiety (HP:0000739)2.59289652
37Impaired smooth pursuit (HP:0007772)2.58043111
38Abnormal social behavior (HP:0012433)2.57839532
39Impaired social interactions (HP:0000735)2.57839532
40Hemiplegia (HP:0002301)2.55683864
41Dysdiadochokinesis (HP:0002075)2.55162509
42Abnormal eating behavior (HP:0100738)2.48313972
43Hypoventilation (HP:0002791)2.43145480
44Dysmetria (HP:0001310)2.37542127
45Hypercortisolism (HP:0001578)2.35949088
46Pheochromocytoma (HP:0002666)2.34920424
47Status epilepticus (HP:0002133)2.34823298
48Torticollis (HP:0000473)2.34128607
49Cerebral hypomyelination (HP:0006808)2.33799850
50Abnormality of ocular smooth pursuit (HP:0000617)2.33309291
51Gaze-evoked nystagmus (HP:0000640)2.32963732
52Abnormality of saccadic eye movements (HP:0000570)2.31577918
53Pointed chin (HP:0000307)2.29558539
54Spastic gait (HP:0002064)2.29502688
55Hyperacusis (HP:0010780)2.28165891
56Ventricular fibrillation (HP:0001663)2.28033168
57Urinary urgency (HP:0000012)2.27357214
58Bradykinesia (HP:0002067)2.26582139
59Postural tremor (HP:0002174)2.26434429
60Akinesia (HP:0002304)2.22989568
61Clonus (HP:0002169)2.22965125
62Megalencephaly (HP:0001355)2.22573779
63Limb dystonia (HP:0002451)2.18981649
64Cerebral aneurysm (HP:0004944)2.18551501
65Resting tremor (HP:0002322)2.18421130
66Dysmetric saccades (HP:0000641)2.17667529
67Menstrual irregularities (HP:0000858)2.17538792
68EEG with generalized epileptiform discharges (HP:0011198)2.14567157
69Mutism (HP:0002300)2.13411987
70Intention tremor (HP:0002080)2.12155314
71Epileptiform EEG discharges (HP:0011182)2.11618698
72Hypsarrhythmia (HP:0002521)2.07972095
73Growth hormone excess (HP:0000845)2.07825985
74Focal dystonia (HP:0004373)2.06469734
75Lower limb muscle weakness (HP:0007340)2.06245045
76Scanning speech (HP:0002168)2.05866473
77Delusions (HP:0000746)2.04428408
78Upper limb amyotrophy (HP:0009129)2.02949236
79Distal upper limb amyotrophy (HP:0007149)2.02949236
80Abnormality of calcium-phosphate metabolism (HP:0100530)2.01663386
81Lower limb asymmetry (HP:0100559)2.01573570
82Excessive salivation (HP:0003781)2.00972967
83Drooling (HP:0002307)2.00972967
84Abnormality of the corticospinal tract (HP:0002492)1.99094671
85Broad-based gait (HP:0002136)1.98427878
86Hemiparesis (HP:0001269)1.96020600
87Bronchomalacia (HP:0002780)1.95952465
88Hand muscle atrophy (HP:0009130)1.94142246
89Amblyopia (HP:0000646)1.93734927
90Increased circulating renin level (HP:0000848)1.91578829
91Bundle branch block (HP:0011710)1.88128540
92Craniofacial dystonia (HP:0012179)1.87458271
93Neuroendocrine neoplasm (HP:0100634)1.86551522
94Neuronal loss in central nervous system (HP:0002529)1.86458195
95Anomalous pulmonary venous return (HP:0010772)1.86418515
96Testicular neoplasm (HP:0010788)1.85247349
97Annular pancreas (HP:0001734)1.84486979
98Stereotypic behavior (HP:0000733)1.83292496
99Choreoathetosis (HP:0001266)1.81398713
100Germ cell neoplasia (HP:0100728)1.80490275
101Turricephaly (HP:0000262)1.79930984
102Elfin facies (HP:0004428)1.79647884
103Progressive inability to walk (HP:0002505)1.79244624
104Cerebral inclusion bodies (HP:0100314)1.78096744
105Ankyloglossia (HP:0010296)1.77227255
106Abnormality of the periventricular white matter (HP:0002518)1.77106429
107Rapidly progressive (HP:0003678)1.76530929
108Deeply set eye (HP:0000490)1.75912122
109Lower limb amyotrophy (HP:0007210)1.75760109
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.73887084
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73887084
112Diplopia (HP:0000651)1.73827123
113Abnormality of binocular vision (HP:0011514)1.73827123
114Insidious onset (HP:0003587)1.73537610
115Termporal pattern (HP:0011008)1.73537610
116Mild short stature (HP:0003502)1.73451729
117Spinal canal stenosis (HP:0003416)1.72710902
118Open mouth (HP:0000194)1.72512850
119Apathy (HP:0000741)1.71809365
120Abnormal EKG (HP:0003115)1.71698494
121Papillary thyroid carcinoma (HP:0002895)1.70951240
122Impaired vibratory sensation (HP:0002495)1.70561523
123Striae distensae (HP:0001065)1.69070423
124Bowel diverticulosis (HP:0005222)1.68505251
125Rigidity (HP:0002063)1.67791130
126Overriding aorta (HP:0002623)1.66940279
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65959457
128Abnormality of the fingertips (HP:0001211)1.65548898
129Abnormality of the pulmonary veins (HP:0011718)1.62798441
130Limb ataxia (HP:0002070)1.61819043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.50977218
2MAP3K93.41228425
3PRKD33.27576382
4MAP3K42.93003321
5EPHA42.48811626
6PAK62.37187444
7MINK12.32617293
8MARK12.09102551
9NTRK12.08993759
10KSR22.05308686
11NTRK22.03093151
12CAMKK11.98089329
13MAP2K71.89239770
14MAP2K41.85201657
15STK381.79594993
16DAPK21.73454981
17RIPK11.55233092
18TYRO31.55145948
19PRKCH1.49502350
20MAP3K21.48603618
21BRD41.46688047
22SIK21.45552778
23UHMK11.42982811
24CDK51.41983474
25TRIB31.41587546
26CAMK1G1.30999827
27MAP3K121.29903546
28MAPK121.28452419
29INSRR1.26535314
30RET1.25634925
31KSR11.23420721
32ALK1.22596259
33CDC42BPA1.19465535
34NEK61.16675587
35TAOK11.16592706
36PDGFRA1.16336905
37WNK11.14268354
38CAMKK21.13616588
39JAK11.11665548
40PAK31.10901364
41MAP3K131.08734972
42TNIK1.08229941
43MARK21.05734103
44DAPK11.03406789
45LATS21.01991233
46FGFR41.01705461
47GRK50.99846976
48SIK10.98390726
49PRKCG0.97309410
50MAP4K10.96388161
51MAP3K10.95886324
52PHKG10.93343384
53PHKG20.93343384
54MAPK130.92628788
55SGK30.92582815
56LMTK20.92298520
57RIPK40.91752378
58CAMK10.90936540
59PNCK0.90738523
60SCYL20.90564007
61ICK0.87828891
62STK110.87675434
63SGK4940.86510625
64SGK2230.86510625
65TNK20.86029323
66PRKD20.81343964
67SGK20.77378063
68PRPF4B0.77149420
69HIPK20.77129095
70FES0.75551279
71PLK20.75095623
72PKN20.74005617
73FGFR30.73337912
74NEK10.72757488
75EEF2K0.72425347
76MAP3K110.70564280
77CDK180.69625493
78CDK150.69252646
79FGFR20.69051844
80BMPR20.67864487
81PTK20.66975922
82ITK0.66510584
83AKT30.66433275
84SGK10.66188671
85DMPK0.65922907
86CDK140.65877777
87DDR20.65618462
88SIK30.65179810
89MAPK100.64736983
90ARAF0.63998734
91CAMK2A0.63808854
92CAMK1D0.63142207
93RPS6KA30.63021336
94MAPK150.61197160
95IRAK20.61024578
96ERN10.60894061
97FER0.60765002
98CDK190.60161212
99CDK11A0.60092101
100CAMK40.59515433
101MAPK70.59413574
102WNK30.58701753
103RPS6KA20.58694314
104MAP3K70.58367285
105CSNK1G20.57671149
106PDK10.56312313
107BRSK10.55988413
108PINK10.55569545
109TXK0.54702030
110PDPK10.54280782
111DYRK1A0.53948161
112IKBKE0.53620652
113CAMK2B0.47519555
114JAK20.46764050
115GRK60.46329747
116RAF10.45605144
117BMX0.44942256
118CDK120.44938192
119MAP3K140.44918520
120EPHA30.43413802
121MAP2K60.43353894
122MAP2K20.42923636
123MAPK40.42850238
124CAMK2G0.42520904
125PRKD10.42502481
126FYN0.41911322
127EPHB10.40318131
128CAMK2D0.38930921
129TBK10.38201299
130MAPK80.36584261

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.14429157
2Nicotine addiction_Homo sapiens_hsa050332.84859620
3GABAergic synapse_Homo sapiens_hsa047272.51274094
4Circadian entrainment_Homo sapiens_hsa047132.34482752
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32153344
6Insulin secretion_Homo sapiens_hsa049112.29797938
7Long-term potentiation_Homo sapiens_hsa047202.29316270
8Olfactory transduction_Homo sapiens_hsa047402.28000683
9Amphetamine addiction_Homo sapiens_hsa050312.25309306
10Morphine addiction_Homo sapiens_hsa050322.15906027
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10921761
12Glutamatergic synapse_Homo sapiens_hsa047242.05481905
13Dopaminergic synapse_Homo sapiens_hsa047282.00998777
14Cocaine addiction_Homo sapiens_hsa050301.97694432
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88832315
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85778755
17Salivary secretion_Homo sapiens_hsa049701.80104670
18Cholinergic synapse_Homo sapiens_hsa047251.73698817
19Type II diabetes mellitus_Homo sapiens_hsa049301.72770400
20Gastric acid secretion_Homo sapiens_hsa049711.69422463
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62626951
22Renin secretion_Homo sapiens_hsa049241.52437814
23Taste transduction_Homo sapiens_hsa047421.47143839
24Oxytocin signaling pathway_Homo sapiens_hsa049211.43285371
25Long-term depression_Homo sapiens_hsa047301.42230626
26GnRH signaling pathway_Homo sapiens_hsa049121.40496198
27Serotonergic synapse_Homo sapiens_hsa047261.33659761
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32835418
29cAMP signaling pathway_Homo sapiens_hsa040241.28935570
30Estrogen signaling pathway_Homo sapiens_hsa049151.28577395
31Calcium signaling pathway_Homo sapiens_hsa040201.25042980
32Gap junction_Homo sapiens_hsa045401.24846318
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23775762
34Glioma_Homo sapiens_hsa052141.17580222
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14487701
36Collecting duct acid secretion_Homo sapiens_hsa049661.12386623
37T cell receptor signaling pathway_Homo sapiens_hsa046601.11667448
38Vibrio cholerae infection_Homo sapiens_hsa051101.11371369
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06639611
40Dorso-ventral axis formation_Homo sapiens_hsa043201.04991049
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04633111
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04600933
43Melanogenesis_Homo sapiens_hsa049161.00382777
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99232132
45ErbB signaling pathway_Homo sapiens_hsa040120.98971162
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98598610
47Nitrogen metabolism_Homo sapiens_hsa009100.97666822
48Thyroid hormone synthesis_Homo sapiens_hsa049180.96881022
49mTOR signaling pathway_Homo sapiens_hsa041500.96401964
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.95469356
51B cell receptor signaling pathway_Homo sapiens_hsa046620.94936612
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93589428
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93269156
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.91828047
55Pancreatic secretion_Homo sapiens_hsa049720.91529648
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89307543
57Axon guidance_Homo sapiens_hsa043600.89249180
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.89036056
59Dilated cardiomyopathy_Homo sapiens_hsa054140.87506285
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87094612
61Type I diabetes mellitus_Homo sapiens_hsa049400.81027732
62MAPK signaling pathway_Homo sapiens_hsa040100.80858423
63Oocyte meiosis_Homo sapiens_hsa041140.79453215
64Glucagon signaling pathway_Homo sapiens_hsa049220.77089993
65Choline metabolism in cancer_Homo sapiens_hsa052310.75038874
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72415770
67Acute myeloid leukemia_Homo sapiens_hsa052210.71426698
68Insulin signaling pathway_Homo sapiens_hsa049100.71017774
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70199967
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69349595
71Endocytosis_Homo sapiens_hsa041440.68361982
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68117447
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67727844
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67474770
75Endometrial cancer_Homo sapiens_hsa052130.67346406
76Circadian rhythm_Homo sapiens_hsa047100.66741594
77VEGF signaling pathway_Homo sapiens_hsa043700.66584632
78Inositol phosphate metabolism_Homo sapiens_hsa005620.64085068
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63850855
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61646740
81Non-small cell lung cancer_Homo sapiens_hsa052230.60929878
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59236800
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59000277
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58428531
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.57739879
86Prolactin signaling pathway_Homo sapiens_hsa049170.57690067
87Alcoholism_Homo sapiens_hsa050340.56935847
88Rap1 signaling pathway_Homo sapiens_hsa040150.56044586
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55515231
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55366660
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54792716
92Osteoclast differentiation_Homo sapiens_hsa043800.54527701
93Ras signaling pathway_Homo sapiens_hsa040140.53455129
94Wnt signaling pathway_Homo sapiens_hsa043100.53354473
95Cardiac muscle contraction_Homo sapiens_hsa042600.53105453
96FoxO signaling pathway_Homo sapiens_hsa040680.52888078
97Prion diseases_Homo sapiens_hsa050200.52499660
98AMPK signaling pathway_Homo sapiens_hsa041520.52436965
99Renal cell carcinoma_Homo sapiens_hsa052110.51869823
100Chronic myeloid leukemia_Homo sapiens_hsa052200.51111689
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.47738661
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.47359541
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.46905427
104Ovarian steroidogenesis_Homo sapiens_hsa049130.45777480
105HIF-1 signaling pathway_Homo sapiens_hsa040660.44622294
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44116290
107Notch signaling pathway_Homo sapiens_hsa043300.42395963
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42374331
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42146208
110Phototransduction_Homo sapiens_hsa047440.41995831
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41788547
112Insulin resistance_Homo sapiens_hsa049310.41434014
113Platelet activation_Homo sapiens_hsa046110.41229406
114Colorectal cancer_Homo sapiens_hsa052100.40561113
115Bile secretion_Homo sapiens_hsa049760.40537901
116Lysosome_Homo sapiens_hsa041420.40018714
117TNF signaling pathway_Homo sapiens_hsa046680.39551825
118Hedgehog signaling pathway_Homo sapiens_hsa043400.37999534
119Proteoglycans in cancer_Homo sapiens_hsa052050.37901312
120Chemokine signaling pathway_Homo sapiens_hsa040620.37852349

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »