TSPYL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.14839110
2synaptic vesicle maturation (GO:0016188)6.04256194
3locomotory exploration behavior (GO:0035641)5.57329280
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56959727
5synaptic vesicle exocytosis (GO:0016079)5.52282574
6vocalization behavior (GO:0071625)5.37372977
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30346477
8regulation of synaptic vesicle exocytosis (GO:2000300)5.27246079
9glutamate secretion (GO:0014047)5.19954907
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.96511046
11neurotransmitter secretion (GO:0007269)4.77990198
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.72993058
13regulation of glutamate receptor signaling pathway (GO:1900449)4.69242873
14neuronal action potential propagation (GO:0019227)4.67030415
15regulation of synaptic vesicle transport (GO:1902803)4.66832926
16protein localization to synapse (GO:0035418)4.54696343
17neuron cell-cell adhesion (GO:0007158)4.54330577
18gamma-aminobutyric acid transport (GO:0015812)4.44810380
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.43505836
20exploration behavior (GO:0035640)4.36497394
21regulation of neuronal synaptic plasticity (GO:0048168)4.21574339
22layer formation in cerebral cortex (GO:0021819)4.21182252
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15475534
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05357478
25regulation of synapse structural plasticity (GO:0051823)4.02751951
26synaptic transmission, glutamatergic (GO:0035249)4.02448889
27proline transport (GO:0015824)4.00717149
28establishment of mitochondrion localization (GO:0051654)3.96626997
29cellular potassium ion homeostasis (GO:0030007)3.95955219
30neuron-neuron synaptic transmission (GO:0007270)3.94584520
31neurotransmitter transport (GO:0006836)3.94425234
32glutamate receptor signaling pathway (GO:0007215)3.93712146
33neurotransmitter-gated ion channel clustering (GO:0072578)3.88860676
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86093385
35long-term memory (GO:0007616)3.80402413
36pyrimidine nucleobase catabolic process (GO:0006208)3.78830801
37sodium ion export (GO:0071436)3.73896574
38activation of protein kinase A activity (GO:0034199)3.72367289
39dendritic spine morphogenesis (GO:0060997)3.70009937
40neuromuscular process controlling posture (GO:0050884)3.69013445
41cerebellar Purkinje cell differentiation (GO:0021702)3.67320963
42regulation of neurotransmitter levels (GO:0001505)3.61846800
43positive regulation of membrane potential (GO:0045838)3.60900921
44transmission of nerve impulse (GO:0019226)3.54389453
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53968199
46glycine transport (GO:0015816)3.53542842
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52785509
48synaptic vesicle endocytosis (GO:0048488)3.52698838
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.50112151
50neuron recognition (GO:0008038)3.49657389
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.48941482
52positive regulation of synapse maturation (GO:0090129)3.48750871
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47203305
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47076057
55regulation of neurotransmitter secretion (GO:0046928)3.45261420
56regulation of voltage-gated calcium channel activity (GO:1901385)3.42445015
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40602279
58regulation of postsynaptic membrane potential (GO:0060078)3.39438071
59neuromuscular process controlling balance (GO:0050885)3.39247449
60potassium ion homeostasis (GO:0055075)3.35942904
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.34996459
62regulation of synaptic plasticity (GO:0048167)3.34605034
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.34313002
64amino acid import (GO:0043090)3.30433315
65long-term synaptic potentiation (GO:0060291)3.30129974
66negative regulation of dendrite morphogenesis (GO:0050774)3.27683889
67mitochondrion transport along microtubule (GO:0047497)3.26053763
68establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.26053763
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.25715469
70central nervous system myelination (GO:0022010)3.25295325
71axon ensheathment in central nervous system (GO:0032291)3.25295325
72L-amino acid import (GO:0043092)3.23217030
73regulation of neurotransmitter transport (GO:0051588)3.23011900
74cellular sodium ion homeostasis (GO:0006883)3.22440224
75positive regulation of dendritic spine development (GO:0060999)3.22136461
76regulation of vesicle fusion (GO:0031338)3.21117475
77membrane depolarization during action potential (GO:0086010)3.20255726
78vesicle transport along microtubule (GO:0047496)3.19568706
79dendrite morphogenesis (GO:0048813)3.19426197
80regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18578723
81dendritic spine organization (GO:0097061)3.18299947
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17908886
83postsynaptic membrane organization (GO:0001941)3.17574032
84prepulse inhibition (GO:0060134)3.15948777
85G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15843311
86cell communication by electrical coupling (GO:0010644)3.15255432
87axonal fasciculation (GO:0007413)3.14889569
88auditory behavior (GO:0031223)3.13615840
89response to auditory stimulus (GO:0010996)3.12730777
90regulation of synapse maturation (GO:0090128)3.12410797
91neuronal ion channel clustering (GO:0045161)3.12101161
92membrane hyperpolarization (GO:0060081)3.11924983
93nucleobase catabolic process (GO:0046113)3.11569923
94potassium ion import (GO:0010107)3.09367151
95neuromuscular synaptic transmission (GO:0007274)3.06537120
96membrane depolarization (GO:0051899)3.05876683
97regulation of dendritic spine morphogenesis (GO:0061001)3.05874789
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05814551
99mating behavior (GO:0007617)3.05548456
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04166420
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03960920
102synapse assembly (GO:0007416)3.03123743
103adult walking behavior (GO:0007628)3.02848059
104synaptic vesicle transport (GO:0048489)3.01879166
105establishment of synaptic vesicle localization (GO:0097480)3.01879166
106cerebellar granule cell differentiation (GO:0021707)3.01717845
107synaptic transmission (GO:0007268)3.00847343
108positive regulation of neurotransmitter transport (GO:0051590)3.00467746
109neuromuscular process (GO:0050905)2.97307107
110regulation of synaptic transmission, GABAergic (GO:0032228)2.96941263
111cerebellar Purkinje cell layer development (GO:0021680)2.96573599
112cell migration in hindbrain (GO:0021535)2.96394683
113learning (GO:0007612)2.95657558
114positive regulation of synaptic transmission (GO:0050806)2.95532339
115regulation of synaptic transmission (GO:0050804)2.95260397
116organelle transport along microtubule (GO:0072384)2.95140350
117intraspecies interaction between organisms (GO:0051703)2.95103168
118social behavior (GO:0035176)2.95103168
119positive regulation of potassium ion transmembrane transport (GO:1901381)2.94816938
120positive regulation of synapse assembly (GO:0051965)2.93964940
121innervation (GO:0060384)2.93912083
122cell communication involved in cardiac conduction (GO:0086065)2.93041242
123response to pheromone (GO:0019236)2.92993328
124presynaptic membrane assembly (GO:0097105)2.90944263
125detection of calcium ion (GO:0005513)2.90844413
126presynaptic membrane organization (GO:0097090)2.90498431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82898583
2GBX2_23144817_ChIP-Seq_PC3_Human3.41081526
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11866327
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06736746
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99257127
6REST_21632747_ChIP-Seq_MESCs_Mouse2.85882234
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68550442
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68550442
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60626358
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56661256
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.54230680
12DROSHA_22980978_ChIP-Seq_HELA_Human2.54101067
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54098364
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53128436
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46930606
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46774180
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.43262547
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.38360106
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27364802
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26843752
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18877420
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.18823579
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16106702
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14478266
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10024780
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98450465
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98157455
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96682504
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88708598
30AR_21572438_ChIP-Seq_LNCaP_Human1.84938904
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75520741
32TAF15_26573619_Chip-Seq_HEK293_Human1.70919888
33SMAD4_21799915_ChIP-Seq_A2780_Human1.65307266
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58266953
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.57277884
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56397723
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55617693
38ZNF274_21170338_ChIP-Seq_K562_Hela1.42908692
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40158590
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35815124
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.35308857
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33616902
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33391837
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31016128
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.29756803
46P300_19829295_ChIP-Seq_ESCs_Human1.29453271
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26475581
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26321975
49STAT3_23295773_ChIP-Seq_U87_Human1.24132262
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23202360
51AR_19668381_ChIP-Seq_PC3_Human1.22952611
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.21527483
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.19889763
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18906912
55* AR_25329375_ChIP-Seq_VCAP_Human1.18587529
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18353525
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18092245
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17606809
59IGF1R_20145208_ChIP-Seq_DFB_Human1.17410693
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.17373824
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17087353
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15677095
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12932900
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12658521
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10713524
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.08714831
67RNF2_27304074_Chip-Seq_NSC_Mouse1.08467701
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06773038
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06362601
70* TCF4_23295773_ChIP-Seq_U87_Human1.06287641
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.04663718
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04607998
73KDM2B_26808549_Chip-Seq_K562_Human1.04207527
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03843108
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03533117
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03466419
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02101212
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02028712
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.02023990
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00708414
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00488288
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.99886130
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99554065
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98666920
85AHR_22903824_ChIP-Seq_MCF-7_Human0.98549723
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.97979127
87CTCF_27219007_Chip-Seq_Bcells_Human0.97528005
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96789609
89ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96724126
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94847911
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94256255
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94167842
93* RUNX2_22187159_ChIP-Seq_PCA_Human0.93687975
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.93388308
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93274729
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93114710
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.92130455
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90058812
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89934412
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.89642953
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89635436
102SOX9_26525672_Chip-Seq_HEART_Mouse0.89542615
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88333319
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86968098
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.85486077
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85204479
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85154077
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85154077
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85126989
110VDR_22108803_ChIP-Seq_LS180_Human0.85090118
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.82650136
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82488001
113ER_23166858_ChIP-Seq_MCF-7_Human0.82367876
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82018347
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81032922
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77407808
117DPY_21335234_ChIP-Seq_ESCs_Mouse0.72533533
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.70709512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.08012262
2MP0003880_abnormal_central_pattern4.62537808
3MP0003635_abnormal_synaptic_transmissio4.09910211
4MP0004270_analgesia3.66372131
5MP0009046_muscle_twitch3.44673309
6MP0009745_abnormal_behavioral_response3.37002794
7MP0002064_seizures3.23626452
8MP0002063_abnormal_learning/memory/cond3.20688145
9MP0005423_abnormal_somatic_nervous3.05368217
10MP0001968_abnormal_touch/_nociception2.96678176
11MP0002734_abnormal_mechanical_nocicepti2.75063386
12MP0002572_abnormal_emotion/affect_behav2.74022858
13MP0002272_abnormal_nervous_system2.72666210
14MP0002822_catalepsy2.59381255
15MP0001486_abnormal_startle_reflex2.55434067
16MP0001501_abnormal_sleep_pattern2.32917791
17MP0002735_abnormal_chemical_nociception2.30860373
18MP0002736_abnormal_nociception_after2.26385447
19MP0002733_abnormal_thermal_nociception2.17196261
20MP0001440_abnormal_grooming_behavior2.10241188
21MP0001970_abnormal_pain_threshold2.06647020
22MP0002067_abnormal_sensory_capabilities2.06133973
23MP0008569_lethality_at_weaning2.05450494
24MP0009780_abnormal_chondrocyte_physiolo2.01955932
25MP0002909_abnormal_adrenal_gland1.90661976
26MP0003329_amyloid_beta_deposits1.89743720
27MP0002184_abnormal_innervation1.88687164
28MP0006276_abnormal_autonomic_nervous1.85058027
29MP0004811_abnormal_neuron_physiology1.79043189
30MP0004924_abnormal_behavior1.78800131
31MP0005386_behavior/neurological_phenoty1.78800131
32MP0005646_abnormal_pituitary_gland1.77459090
33MP0002557_abnormal_social/conspecific_i1.75093633
34MP0000778_abnormal_nervous_system1.72819985
35MP0004858_abnormal_nervous_system1.72732735
36MP0000955_abnormal_spinal_cord1.65151987
37MP0003787_abnormal_imprinting1.59101798
38MP0001984_abnormal_olfaction1.57837422
39MP0003122_maternal_imprinting1.52759101
40MP0004885_abnormal_endolymph1.52754223
41MP0004142_abnormal_muscle_tone1.49159054
42MP0002882_abnormal_neuron_morphology1.47615638
43MP0002066_abnormal_motor_capabilities/c1.47378746
44MP0003879_abnormal_hair_cell1.46929251
45MP0005645_abnormal_hypothalamus_physiol1.44937105
46MP0003633_abnormal_nervous_system1.36896991
47MP0003121_genomic_imprinting1.31402006
48MP0001529_abnormal_vocalization1.30183207
49MP0001502_abnormal_circadian_rhythm1.29069218
50MP0001905_abnormal_dopamine_level1.23111741
51MP0005551_abnormal_eye_electrophysiolog1.18374732
52MP0003631_nervous_system_phenotype1.17230464
53MP0002229_neurodegeneration1.16401288
54MP0000013_abnormal_adipose_tissue1.12626207
55MP0008877_abnormal_DNA_methylation1.11354266
56MP0002152_abnormal_brain_morphology1.09810166
57MP0004145_abnormal_muscle_electrophysio1.05634215
58MP0000751_myopathy1.02248504
59MP0002102_abnormal_ear_morphology1.00395532
60MP0003634_abnormal_glial_cell0.98036556
61MP0008872_abnormal_physiological_respon0.96785583
62MP0001986_abnormal_taste_sensitivity0.95636921
63MP0003283_abnormal_digestive_organ0.95499319
64MP0004742_abnormal_vestibular_system0.95368038
65MP0003690_abnormal_glial_cell0.94686093
66MP0010386_abnormal_urinary_bladder0.94466140
67MP0000920_abnormal_myelination0.94232196
68MP0001188_hyperpigmentation0.93648717
69MP0002069_abnormal_eating/drinking_beha0.93459390
70MP0003632_abnormal_nervous_system0.89782030
71MP0000569_abnormal_digit_pigmentation0.88386251
72MP0002653_abnormal_ependyma_morphology0.87827609
73MP0001177_atelectasis0.86654158
74MP0005535_abnormal_body_temperature0.85804760
75MP0005394_taste/olfaction_phenotype0.85279069
76MP0005499_abnormal_olfactory_system0.85279069
77MP0000566_synostosis0.83256777
78MP0001963_abnormal_hearing_physiology0.82881035
79MP0002752_abnormal_somatic_nervous0.82803839
80MP0004085_abnormal_heartbeat0.82480705
81MP0008874_decreased_physiological_sensi0.81899640
82MP0000604_amyloidosis0.81632308
83MP0002638_abnormal_pupillary_reflex0.81429749
84MP0004043_abnormal_pH_regulation0.81273316
85MP0003861_abnormal_nervous_system0.80785583
86MP0003123_paternal_imprinting0.80083771
87MP0000631_abnormal_neuroendocrine_gland0.78746099
88MP0008961_abnormal_basal_metabolism0.78560332
89MP0002090_abnormal_vision0.78004595
90MP0005187_abnormal_penis_morphology0.77365849
91MP0002837_dystrophic_cardiac_calcinosis0.76461210
92MP0006072_abnormal_retinal_apoptosis0.73925789
93MP0008789_abnormal_olfactory_epithelium0.73428596
94MP0004133_heterotaxia0.70284001
95MP0004147_increased_porphyrin_level0.69873062
96MP0004215_abnormal_myocardial_fiber0.69306073
97MP0004233_abnormal_muscle_weight0.67802630
98MP0000026_abnormal_inner_ear0.67674334
99MP0001299_abnormal_eye_distance/0.67236335
100MP0010768_mortality/aging0.66652510
101MP0003137_abnormal_impulse_conducting0.66013630
102MP0003172_abnormal_lysosome_physiology0.63528875
103MP0003075_altered_response_to0.62379120
104MP0005623_abnormal_meninges_morphology0.61993520
105MP0001485_abnormal_pinna_reflex0.61951260
106MP0005253_abnormal_eye_physiology0.58754305
107MP0001943_abnormal_respiration0.58291504
108MP0002249_abnormal_larynx_morphology0.57776873
109MP0004484_altered_response_of0.57623307
110MP0001664_abnormal_digestion0.57139547
111MP0003938_abnormal_ear_development0.55648938
112MP0002876_abnormal_thyroid_physiology0.55550093
113MP0010769_abnormal_survival0.55225789
114MP0010770_preweaning_lethality0.53570123
115MP0002082_postnatal_lethality0.53570123
116MP0000639_abnormal_adrenal_gland0.53069017
117MP0003956_abnormal_body_size0.51662806

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.27232552
2Myokymia (HP:0002411)6.66108329
3Focal seizures (HP:0007359)5.52497080
4Visual hallucinations (HP:0002367)5.42592983
5Atonic seizures (HP:0010819)4.76371694
6Epileptic encephalopathy (HP:0200134)4.57175670
7Progressive cerebellar ataxia (HP:0002073)4.49600811
8Febrile seizures (HP:0002373)4.43531411
9Action tremor (HP:0002345)4.22074471
10Absence seizures (HP:0002121)4.19382118
11Supranuclear gaze palsy (HP:0000605)3.92195313
12Generalized tonic-clonic seizures (HP:0002069)3.80238370
13Dialeptic seizures (HP:0011146)3.77967036
14Ankle clonus (HP:0011448)3.74668174
15Depression (HP:0000716)3.34303850
16Broad-based gait (HP:0002136)3.34088150
17Dysdiadochokinesis (HP:0002075)3.25488568
18Gaze-evoked nystagmus (HP:0000640)3.24814228
19Abnormal eating behavior (HP:0100738)3.21663682
20Truncal ataxia (HP:0002078)3.18679553
21Impaired vibration sensation in the lower limbs (HP:0002166)3.15871400
22Poor eye contact (HP:0000817)3.15519271
23Mutism (HP:0002300)3.11792316
24Dysmetria (HP:0001310)3.06214847
25Anxiety (HP:0000739)3.05308339
26Postural instability (HP:0002172)3.00615399
27Urinary bladder sphincter dysfunction (HP:0002839)3.00182249
28Abnormal social behavior (HP:0012433)2.96853199
29Impaired social interactions (HP:0000735)2.96853199
30Papilledema (HP:0001085)2.95985242
31Pheochromocytoma (HP:0002666)2.93966908
32Progressive inability to walk (HP:0002505)2.90856793
33Limb dystonia (HP:0002451)2.79913355
34Scanning speech (HP:0002168)2.79568639
35Hyperventilation (HP:0002883)2.79422226
36Sleep apnea (HP:0010535)2.78867076
37Spastic gait (HP:0002064)2.77529219
38Abnormality of the lower motor neuron (HP:0002366)2.75054630
39Urinary urgency (HP:0000012)2.70196143
40Genetic anticipation (HP:0003743)2.66227753
41Intention tremor (HP:0002080)2.66064721
42Hemiparesis (HP:0001269)2.64291362
43Cerebral hypomyelination (HP:0006808)2.63750425
44Impaired smooth pursuit (HP:0007772)2.61420229
45Diplopia (HP:0000651)2.61135194
46Abnormality of binocular vision (HP:0011514)2.61135194
47Hemiplegia (HP:0002301)2.58623166
48Neurofibrillary tangles (HP:0002185)2.56267763
49Amblyopia (HP:0000646)2.56267586
50Torticollis (HP:0000473)2.55978501
51Neuroendocrine neoplasm (HP:0100634)2.54085653
52Ventricular fibrillation (HP:0001663)2.53991352
53Excessive salivation (HP:0003781)2.53785534
54Drooling (HP:0002307)2.53785534
55Bradykinesia (HP:0002067)2.49652743
56Abnormality of the corticospinal tract (HP:0002492)2.47604733
57Cerebral inclusion bodies (HP:0100314)2.44111813
58Morphological abnormality of the pyramidal tract (HP:0002062)2.41156144
59Insidious onset (HP:0003587)2.40822655
60Termporal pattern (HP:0011008)2.40822655
61Obstructive sleep apnea (HP:0002870)2.39637551
62Agitation (HP:0000713)2.38502499
63Polyphagia (HP:0002591)2.38447812
64Epileptiform EEG discharges (HP:0011182)2.38349833
65Focal dystonia (HP:0004373)2.37618843
66EEG with generalized epileptiform discharges (HP:0011198)2.35058767
67Abnormality of ocular smooth pursuit (HP:0000617)2.33500172
68Delusions (HP:0000746)2.32625328
69Dysmetric saccades (HP:0000641)2.30151180
70Poor suck (HP:0002033)2.29711212
71Megalencephaly (HP:0001355)2.29638510
72Fetal akinesia sequence (HP:0001989)2.26733916
73Hypsarrhythmia (HP:0002521)2.26669843
74Lower limb muscle weakness (HP:0007340)2.25289517
75Status epilepticus (HP:0002133)2.24151152
76Peripheral hypomyelination (HP:0007182)2.18696752
77Failure to thrive in infancy (HP:0001531)2.17681877
78Stereotypic behavior (HP:0000733)2.16808222
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14861297
80Craniofacial dystonia (HP:0012179)2.14241446
81Split foot (HP:0001839)2.12994718
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12192619
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.12192619
84Myotonia (HP:0002486)2.11918770
85Amyotrophic lateral sclerosis (HP:0007354)2.10961177
86Neuronal loss in central nervous system (HP:0002529)2.08623216
87Spastic tetraplegia (HP:0002510)2.07989739
88Clonus (HP:0002169)2.07770440
89Impaired vibratory sensation (HP:0002495)2.07196623
90Generalized myoclonic seizures (HP:0002123)2.06959169
91Absent speech (HP:0001344)2.05095781
92Inability to walk (HP:0002540)2.04147155
93Gait ataxia (HP:0002066)1.99605417
94Abnormality of saccadic eye movements (HP:0000570)1.99600104
95Insomnia (HP:0100785)1.96767646
96Psychosis (HP:0000709)1.93628010
97Postural tremor (HP:0002174)1.92575959
98Neoplasm of the peripheral nervous system (HP:0100007)1.92268419
99Blue irides (HP:0000635)1.91974084
100Prolonged QT interval (HP:0001657)1.90991907
101Rigidity (HP:0002063)1.89592665
102Resting tremor (HP:0002322)1.88858312
103Annular pancreas (HP:0001734)1.88366007
104Heterochromia iridis (HP:0001100)1.87916057
105Specific learning disability (HP:0001328)1.87101782
106Akinesia (HP:0002304)1.85966634
107Hand muscle atrophy (HP:0009130)1.85311176
108Hammertoe (HP:0001765)1.84849784
109Pointed chin (HP:0000307)1.84399838
110Hypoventilation (HP:0002791)1.84337361
111Gait imbalance (HP:0002141)1.84075136
112Aplasia involving bones of the upper limbs (HP:0009823)1.84043174
113Aplasia of the phalanges of the hand (HP:0009802)1.84043174
114Aplasia involving bones of the extremities (HP:0009825)1.84043174
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81731229
116CNS hypomyelination (HP:0003429)1.81373893
117Incomplete penetrance (HP:0003829)1.81332853
118Apathy (HP:0000741)1.78516831
119Rapidly progressive (HP:0003678)1.77378861
120Central scotoma (HP:0000603)1.75084474
121Abnormal EKG (HP:0003115)1.74626691
122Tetraplegia (HP:0002445)1.73794475
123Ulnar claw (HP:0001178)1.73541578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.34448454
2MAP3K93.79230158
3MARK13.44040842
4MAP3K43.23975849
5EPHA43.14772920
6MINK12.86180010
7MAP2K72.67631546
8PAK62.30991570
9NTRK22.26631683
10DAPK22.18685628
11MAP3K122.13263209
12MAP2K42.05831852
13NTRK12.04272108
14KSR21.93993518
15PRKD31.90737516
16CASK1.88777556
17CAMKK11.88362064
18CDK51.55962963
19GRK51.53991947
20CDK191.53558806
21STK381.44141981
22BCR1.43701459
23PNCK1.42587993
24MAPK131.36784673
25UHMK11.35657507
26PLK21.35150113
27RIPK41.32436414
28TNIK1.31543861
29CAMKK21.31461502
30KSR11.30817336
31PRKCG1.25869420
32PHKG11.25731793
33PHKG21.25731793
34ARAF1.23377614
35DAPK11.23170288
36SIK21.15947714
37MAP3K21.13885753
38PRPF4B1.12815462
39SGK4941.12529141
40SGK2231.12529141
41DYRK21.11924580
42FES1.11658563
43CSNK1G31.07474612
44TYRO31.07072383
45LATS21.03990753
46LMTK21.03076961
47PRKCH1.00373917
48CSNK1A1L1.00200359
49CAMK2A0.96802361
50OXSR10.94700825
51CDK180.92559006
52PINK10.92085865
53CDK150.91673341
54CDK140.91159030
55STK110.90030339
56RET0.89496827
57TESK10.88033878
58WNK10.87831590
59SGK20.86401597
60TAOK10.84042372
61CAMK10.82262878
62PAK30.81857628
63MAP3K130.79851647
64CAMK2B0.79779536
65CDK11A0.79100016
66CSNK1G20.78235267
67ALK0.78100045
68SGK30.76963316
69MAP4K20.76136923
70DYRK1A0.71106670
71CSNK1G10.70772130
72SCYL20.70743813
73TNK20.69078087
74MAP3K110.67606378
75MARK20.64966662
76SGK10.63364914
77MAP3K10.62252145
78PDK10.59065530
79CDC42BPA0.58924309
80NEK10.58741156
81RIPK10.58650207
82CAMK2D0.56935431
83CAMK2G0.56457285
84PDPK10.56139252
85PRKCE0.55243870
86RAF10.53541925
87WNK30.53201309
88PRKCZ0.52185533
89RPS6KA30.51732275
90CAMK1G0.50353460
91MAPK150.49928979
92AKT30.48930706
93MAP3K50.47622003
94FER0.47018706
95MAPK100.46806044
96PTK2B0.46133765
97FYN0.45514334
98MAPK120.45235596
99CSNK1D0.44528431
100NEK60.43942311
101BMPR20.43399127
102LIMK10.43175587
103EPHA30.42523055
104ROCK20.41684126
105STK390.41613671
106BRSK10.41397551
107MAPKAPK50.40297548
108RPS6KA20.40285263
109PKN10.38188251
110CAMK40.38005118
111BCKDK0.35676521
112MAP2K10.34664400
113PRKCB0.33962158
114CCNB10.33863203
115DYRK1B0.33480356
116MAPK80.32967270
117PRKACA0.31037520
118CSNK1E0.30515331
119CSNK1A10.28580613
120PRKCA0.28571340

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68183707
2Synaptic vesicle cycle_Homo sapiens_hsa047213.60594707
3GABAergic synapse_Homo sapiens_hsa047272.89275340
4Olfactory transduction_Homo sapiens_hsa047402.69545008
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64477984
6Circadian entrainment_Homo sapiens_hsa047132.60992970
7Glutamatergic synapse_Homo sapiens_hsa047242.49807595
8Morphine addiction_Homo sapiens_hsa050322.49279174
9Long-term potentiation_Homo sapiens_hsa047202.47876776
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.34449826
11Amphetamine addiction_Homo sapiens_hsa050312.30763227
12Dopaminergic synapse_Homo sapiens_hsa047282.15694743
13Insulin secretion_Homo sapiens_hsa049112.07983595
14Salivary secretion_Homo sapiens_hsa049702.07466402
15Cholinergic synapse_Homo sapiens_hsa047251.87297877
16Gastric acid secretion_Homo sapiens_hsa049711.85831731
17Taste transduction_Homo sapiens_hsa047421.82824634
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75897758
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73163004
20Long-term depression_Homo sapiens_hsa047301.70126010
21Collecting duct acid secretion_Homo sapiens_hsa049661.67289023
22Serotonergic synapse_Homo sapiens_hsa047261.66708531
23Cocaine addiction_Homo sapiens_hsa050301.66475933
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64565921
25Renin secretion_Homo sapiens_hsa049241.58677155
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51156608
27Calcium signaling pathway_Homo sapiens_hsa040201.44038952
28GnRH signaling pathway_Homo sapiens_hsa049121.36380800
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33959599
30Gap junction_Homo sapiens_hsa045401.33518846
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31400760
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28535583
33Type II diabetes mellitus_Homo sapiens_hsa049301.24858258
34cAMP signaling pathway_Homo sapiens_hsa040241.19521001
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15252936
36Estrogen signaling pathway_Homo sapiens_hsa049151.13239570
37Vibrio cholerae infection_Homo sapiens_hsa051101.12347991
38Phototransduction_Homo sapiens_hsa047441.11979289
39Nitrogen metabolism_Homo sapiens_hsa009101.10016094
40Cardiac muscle contraction_Homo sapiens_hsa042601.02579723
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00608636
42Axon guidance_Homo sapiens_hsa043601.00371775
43Glioma_Homo sapiens_hsa052140.99299028
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98103063
45ErbB signaling pathway_Homo sapiens_hsa040120.96730061
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94664415
47Melanogenesis_Homo sapiens_hsa049160.92533490
48Pancreatic secretion_Homo sapiens_hsa049720.87839913
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.86725215
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84433157
51Oocyte meiosis_Homo sapiens_hsa041140.83487298
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83426796
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81171989
54Thyroid hormone synthesis_Homo sapiens_hsa049180.79814136
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.78775285
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71920969
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70186464
58Type I diabetes mellitus_Homo sapiens_hsa049400.69170152
59Dilated cardiomyopathy_Homo sapiens_hsa054140.68344122
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67981174
61MAPK signaling pathway_Homo sapiens_hsa040100.67024405
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66985104
63Choline metabolism in cancer_Homo sapiens_hsa052310.63211111
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61550955
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.60568837
66Inositol phosphate metabolism_Homo sapiens_hsa005620.54547324
67Alcoholism_Homo sapiens_hsa050340.54417182
68Hippo signaling pathway_Homo sapiens_hsa043900.54368680
69Glucagon signaling pathway_Homo sapiens_hsa049220.54283582
70Endocytosis_Homo sapiens_hsa041440.53608523
71Ras signaling pathway_Homo sapiens_hsa040140.53154332
72Bile secretion_Homo sapiens_hsa049760.52668316
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51866186
74Regulation of autophagy_Homo sapiens_hsa041400.51214655
75Vitamin B6 metabolism_Homo sapiens_hsa007500.51178443
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49178904
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49081204
78mTOR signaling pathway_Homo sapiens_hsa041500.48769808
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.48696163
80VEGF signaling pathway_Homo sapiens_hsa043700.46140108
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45961375
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45872028
83Rap1 signaling pathway_Homo sapiens_hsa040150.45119606
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44031291
85Circadian rhythm_Homo sapiens_hsa047100.43467664
86Endometrial cancer_Homo sapiens_hsa052130.42512081
87Renal cell carcinoma_Homo sapiens_hsa052110.42063459
88Alzheimers disease_Homo sapiens_hsa050100.41634345
89Insulin signaling pathway_Homo sapiens_hsa049100.40976554
90AMPK signaling pathway_Homo sapiens_hsa041520.40652021
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40104001
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39997752
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38978193
94Prion diseases_Homo sapiens_hsa050200.38797557
95Ovarian steroidogenesis_Homo sapiens_hsa049130.36961066
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36930482
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36695879
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35931974
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35923550
100Butanoate metabolism_Homo sapiens_hsa006500.35001362
101Arginine and proline metabolism_Homo sapiens_hsa003300.33576271
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32490062
103Tight junction_Homo sapiens_hsa045300.31966057
104Non-small cell lung cancer_Homo sapiens_hsa052230.31431889
105Wnt signaling pathway_Homo sapiens_hsa043100.31427217
106Chemokine signaling pathway_Homo sapiens_hsa040620.28868496
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28669997
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.25679775
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25293077
110Oxidative phosphorylation_Homo sapiens_hsa001900.25097624
111Hedgehog signaling pathway_Homo sapiens_hsa043400.23334337
112beta-Alanine metabolism_Homo sapiens_hsa004100.22163365
113Arginine biosynthesis_Homo sapiens_hsa002200.16518264

Most similar genes based on co-expression Upload to Enrichr

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