TSPYL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex organization (GO:0070193)9.58414446
2histone H3-K36 demethylation (GO:0070544)9.39863267
3meiotic nuclear division (GO:0007126)9.19124715
4DNA synthesis involved in DNA repair (GO:0000731)9.17582348
5meiotic chromosome segregation (GO:0045132)8.89989365
6histone H3-K9 demethylation (GO:0033169)8.20003433
7sister chromatid cohesion (GO:0007062)7.19812748
8positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc7.01424926
9meiotic cell cycle process (GO:1903046)6.79535658
10regulation of transcription from RNA polymerase I promoter (GO:0006356)6.77573905
11regulation of meiosis I (GO:0060631)6.68206700
12negative regulation of gene silencing (GO:0060969)6.37597268
13growth hormone receptor signaling pathway (GO:0060396)6.29798037
14signal complex assembly (GO:0007172)6.21110355
15positive regulation of response to oxidative stress (GO:1902884)6.02959990
16positive regulation of cellular response to oxidative stress (GO:1900409)6.02959990
17reciprocal DNA recombination (GO:0035825)5.77089877
18reciprocal meiotic recombination (GO:0007131)5.77089877
19cellular response to growth hormone stimulus (GO:0071378)5.63044745
20regulation of DNA endoreduplication (GO:0032875)5.52443164
21regulation of histone H3-K9 methylation (GO:0051570)5.43790188
22resolution of meiotic recombination intermediates (GO:0000712)5.15421011
23gene silencing by RNA (GO:0031047)4.83192153
24histone H4-K12 acetylation (GO:0043983)4.60430175
25embryonic body morphogenesis (GO:0010172)4.47128670
26sex differentiation (GO:0007548)4.46310636
27establishment of nucleus localization (GO:0040023)4.40040914
28mitotic sister chromatid cohesion (GO:0007064)4.35866689
29DNA methylation (GO:0006306)4.35131434
30DNA alkylation (GO:0006305)4.35131434
31mating behavior (GO:0007617)4.26219511
32regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:24.21232076
33regulation of chromatin silencing (GO:0031935)4.20428252
34genitalia morphogenesis (GO:0035112)4.09632092
35regulation of NFAT protein import into nucleus (GO:0051532)4.03887544
36mitotic chromosome condensation (GO:0007076)3.99852190
37mismatch repair (GO:0006298)3.95021489
38female gamete generation (GO:0007292)3.93576853
39positive regulation of meiosis (GO:0045836)3.82003643
40positive regulation of gene expression, epigenetic (GO:0045815)3.81938695
41histone lysine demethylation (GO:0070076)3.78066459
42nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.78040915
43diterpenoid biosynthetic process (GO:0016102)3.76321316
44histone H4-K16 acetylation (GO:0043984)3.73964593
45regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.72831363
46histone demethylation (GO:0016577)3.69589199
47body morphogenesis (GO:0010171)3.60796249
48positive regulation of meiotic cell cycle (GO:0051446)3.55081499
49nucleus localization (GO:0051647)3.53171307
50histone H2A acetylation (GO:0043968)3.50458746
51negative regulation of inclusion body assembly (GO:0090084)3.48746659
52nuclear pore complex assembly (GO:0051292)3.47639605
53histone H4-K5 acetylation (GO:0043981)3.46136761
54histone H4-K8 acetylation (GO:0043982)3.46136761
55protein localization to chromosome (GO:0034502)3.43384747
56chromosome organization (GO:0051276)3.41668623
57regulation of RNA export from nucleus (GO:0046831)3.40278357
58reproductive system development (GO:0061458)3.38342220
59protein dealkylation (GO:0008214)3.34219982
60protein demethylation (GO:0006482)3.34219982
61attachment of spindle microtubules to kinetochore (GO:0008608)3.31165145
62interkinetic nuclear migration (GO:0022027)3.27085107
63meiotic cell cycle (GO:0051321)3.18393628
64DNA methylation or demethylation (GO:0044728)3.11873410
65vitamin A metabolic process (GO:0006776)3.10393226
66regulation of meiotic cell cycle (GO:0051445)3.05803467
67macroautophagy (GO:0016236)3.05246427
68regulation of microtubule-based movement (GO:0060632)3.02566502
69DNA biosynthetic process (GO:0071897)2.99401859
70nuclear division (GO:0000280)2.97684087
71mitotic spindle assembly checkpoint (GO:0007094)2.92548494
72DNA replication initiation (GO:0006270)2.88353348
73protein refolding (GO:0042026)2.88258081
74response to growth hormone (GO:0060416)2.87018485
75spindle assembly checkpoint (GO:0071173)2.86189027
76spermatid development (GO:0007286)2.83925029
77mitotic spindle checkpoint (GO:0071174)2.82940376
78gene silencing (GO:0016458)2.82389752
79regulation of oxidative stress-induced neuron death (GO:1903203)2.81392567
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.80270527
81response to misfolded protein (GO:0051788)2.79556491
82negative regulation of mitotic sister chromatid separation (GO:2000816)2.76059035
83negative regulation of sister chromatid segregation (GO:0033046)2.76059035
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76059035
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76059035
86negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76059035
87organelle fission (GO:0048285)2.75954509
88positive regulation of histone methylation (GO:0031062)2.75902502
89pericardium development (GO:0060039)2.72452502
90nuclear pore organization (GO:0006999)2.71343846
91regulation of mitotic sister chromatid segregation (GO:0033047)2.69233764
92regulation of sister chromatid segregation (GO:0033045)2.69233764
93synapsis (GO:0007129)14.3255942
94male meiosis I (GO:0007141)12.4265417
95chromosome organization involved in meiosis (GO:0070192)12.1813373
96piRNA metabolic process (GO:0034587)11.5135364
97synaptonemal complex assembly (GO:0007130)10.6735280
98DNA methylation involved in gamete generation (GO:0043046)10.5948023
99male meiosis (GO:0007140)10.3234561
100meiosis I (GO:0007127)10.0371618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.05247053
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.57895925
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.61620227
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.47173961
5POU5F1_18555785_ChIP-Seq_MESCs_Mouse3.25391444
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81063218
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74408453
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67192120
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65312062
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.64011192
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54912209
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.45815279
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31433359
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.28385534
15RNF2_27304074_Chip-Seq_NSC_Mouse2.27931166
16MYCN_18555785_ChIP-Seq_MESCs_Mouse2.26293357
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.06355903
18FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04245469
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99366038
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88353931
21PKCTHETA_26484144_Chip-Seq_BREAST_Human1.87944825
22KDM5A_27292631_Chip-Seq_BREAST_Human1.87904766
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82356294
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80368770
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79802139
26YY1_22570637_ChIP-Seq_MALME-3M_Human1.73080750
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62718567
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.60258479
29FUS_26573619_Chip-Seq_HEK293_Human1.56043864
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54951352
31ER_23166858_ChIP-Seq_MCF-7_Human1.53392541
32CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.52253056
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50010897
34RUNX1_26923725_Chip-Seq_HPCs_Mouse1.45804208
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43118287
36ZNF274_21170338_ChIP-Seq_K562_Hela1.39404850
37VDR_22108803_ChIP-Seq_LS180_Human1.38881267
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35183633
39BCAT_22108803_ChIP-Seq_LS180_Human1.34122156
40GABP_19822575_ChIP-Seq_HepG2_Human1.33522750
41SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.31898252
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26372970
43TP53_22573176_ChIP-Seq_HFKS_Human1.22864541
44GATA3_26560356_Chip-Seq_TH1_Human1.22809834
45E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22284601
46MYC_18940864_ChIP-ChIP_HL60_Human1.18248184
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17729679
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16407150
49TAF15_26573619_Chip-Seq_HEK293_Human1.16363116
50ERA_21632823_ChIP-Seq_H3396_Human1.14655538
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13790603
52DCP1A_22483619_ChIP-Seq_HELA_Human1.12799360
53PHF8_20622853_ChIP-Seq_HELA_Human1.10812792
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07947613
55TP53_16413492_ChIP-PET_HCT116_Human1.06328612
56TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05551861
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05476905
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04669111
59REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03053576
60STAT3_23295773_ChIP-Seq_U87_Human1.02980752
61TTF2_22483619_ChIP-Seq_HELA_Human1.02630584
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02506222
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01931511
64TCF4_23295773_ChIP-Seq_U87_Human1.01792579
65IGF1R_20145208_ChIP-Seq_DFB_Human1.01659721
66TP63_19390658_ChIP-ChIP_HaCaT_Human0.94889500
67BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.94649141
68GABP_17652178_ChIP-ChIP_JURKAT_Human0.94344866
69KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93594148
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93321265
71EGR1_19032775_ChIP-ChIP_M12_Human0.92517623
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92067609
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89993733
74RUNX2_22187159_ChIP-Seq_PCA_Human0.89420831
75KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88841435
76EWS_26573619_Chip-Seq_HEK293_Human0.86857225
77* ETV1_20927104_ChIP-Seq_GIST48_Human0.86570889
78TFEB_21752829_ChIP-Seq_HELA_Human0.85789994
79TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85518450
80FOXH1_21741376_ChIP-Seq_EPCs_Human0.85116922
81SMC4_20622854_ChIP-Seq_HELA_Human0.84864426
82MYC_18555785_ChIP-Seq_MESCs_Mouse0.84291981
83* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83947565
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83622506
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83524994
86NFYB_21822215_ChIP-Seq_K562_Human0.83183612
87HOXB7_26014856_ChIP-Seq_BT474_Human0.80721963
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80557413
89TET1_21490601_ChIP-Seq_MESCs_Mouse0.79164369
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78597499
91HTT_18923047_ChIP-ChIP_STHdh_Human0.78528356
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.77814877
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.77707941
94MYC_19829295_ChIP-Seq_ESCs_Human0.77022276
95VDR_23849224_ChIP-Seq_CD4+_Human0.76712339
96ETS1_20019798_ChIP-Seq_JURKAT_Human0.76257615
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.74273220
98SOX2_21211035_ChIP-Seq_LN229_Human0.73669637
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72611591
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72075609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.80007146
2MP0002210_abnormal_sex_determination4.16012235
3MP0002160_abnormal_reproductive_system4.13252039
4MP0008995_early_reproductive_senescence3.94000263
5MP0000383_abnormal_hair_follicle3.51321151
6MP0001929_abnormal_gametogenesis3.43777139
7MP0003646_muscle_fatigue3.41588669
8MP0008058_abnormal_DNA_repair3.39878428
9MP0005409_darkened_coat_color3.16484860
10MP0001145_abnormal_male_reproductive3.06575509
11MP0003698_abnormal_male_reproductive2.92781323
12MP0000653_abnormal_sex_gland2.77918211
13MP0010678_abnormal_skin_adnexa2.73173752
14MP0000015_abnormal_ear_pigmentation2.65649255
15MP0003693_abnormal_embryo_hatching2.65248391
16MP0005389_reproductive_system_phenotype2.64199760
17MP0000678_abnormal_parathyroid_gland2.63424689
18MP0000427_abnormal_hair_cycle2.62245877
19MP0000569_abnormal_digit_pigmentation2.50473771
20MP0005174_abnormal_tail_pigmentation2.46673667
21MP0010094_abnormal_chromosome_stability2.29712669
22MP0008057_abnormal_DNA_replication2.27402147
23MP0003786_premature_aging2.20806034
24MP0001661_extended_life_span1.89110725
25MP0008007_abnormal_cellular_replicative1.76912686
26MP0001119_abnormal_female_reproductive1.62612274
27MP0003123_paternal_imprinting1.56611103
28MP0006035_abnormal_mitochondrial_morpho1.56548010
29MP0002161_abnormal_fertility/fecundity1.55252430
30MP0003111_abnormal_nucleus_morphology1.53523115
31MP0008004_abnormal_stomach_pH1.51544625
32MP0003119_abnormal_digestive_system1.50226071
33MP0004233_abnormal_muscle_weight1.50098297
34MP0003453_abnormal_keratinocyte_physiol1.44425444
35MP0003943_abnormal_hepatobiliary_system1.43927457
36MP0001243_abnormal_dermal_layer1.42407780
37MP0000647_abnormal_sebaceous_gland1.42047584
38MP0003699_abnormal_female_reproductive1.34584581
39MP0004808_abnormal_hematopoietic_stem1.29380757
40MP0000013_abnormal_adipose_tissue1.25764931
41MP0003937_abnormal_limbs/digits/tail_de1.21546620
42MP0003077_abnormal_cell_cycle1.20145684
43MP0002095_abnormal_skin_pigmentation1.18370703
44MP0003890_abnormal_embryonic-extraembry1.13698564
45MP0002084_abnormal_developmental_patter1.09624261
46MP0002089_abnormal_postnatal_growth/wei1.09087428
47MP0003936_abnormal_reproductive_system1.02991392
48MP0002249_abnormal_larynx_morphology0.95465744
49MP0001730_embryonic_growth_arrest0.91394410
50MP0001984_abnormal_olfaction0.91211232
51MP0001919_abnormal_reproductive_system0.91028563
52MP0004957_abnormal_blastocyst_morpholog0.84684386
53MP0001915_intracranial_hemorrhage0.84363696
54MP0001697_abnormal_embryo_size0.84354790
55MP0003115_abnormal_respiratory_system0.84159954
56MP0009703_decreased_birth_body0.83906398
57MP0005410_abnormal_fertilization0.80017152
58MP0004036_abnormal_muscle_relaxation0.79811051
59MP0004019_abnormal_vitamin_homeostasis0.79806517
60MP0008789_abnormal_olfactory_epithelium0.78918045
61MP0002132_abnormal_respiratory_system0.78213236
62MP0005310_abnormal_salivary_gland0.74038136
63MP0000313_abnormal_cell_death0.71933475
64MP0005451_abnormal_body_composition0.71121215
65MP0001188_hyperpigmentation0.70726661
66MP0003959_abnormal_lean_body0.66503030
67MP0000358_abnormal_cell_content/0.63444402
68MP0001672_abnormal_embryogenesis/_devel0.62841839
69MP0005380_embryogenesis_phenotype0.62841839
70MP0002269_muscular_atrophy0.62799494
71MP0000350_abnormal_cell_proliferation0.61959029
72MP0001216_abnormal_epidermal_layer0.61770525
73MP0003718_maternal_effect0.61518921
74MP0009379_abnormal_foot_pigmentation0.61425062
75MP0003984_embryonic_growth_retardation0.59402061
76MP0005394_taste/olfaction_phenotype0.58441574
77MP0005499_abnormal_olfactory_system0.58441574
78MP0002971_abnormal_brown_adipose0.58017472
79MP0001542_abnormal_bone_strength0.58001625
80MP0001764_abnormal_homeostasis0.57901116
81MP0002928_abnormal_bile_duct0.56875744
82MP0008932_abnormal_embryonic_tissue0.56649351
83MP0010307_abnormal_tumor_latency0.55687554
84MP0002088_abnormal_embryonic_growth/wei0.55443943
85MP0008260_abnormal_autophagy0.54767801
86MP0000377_abnormal_hair_follicle0.52765241
87MP0002085_abnormal_embryonic_tissue0.50179704
88MP0000749_muscle_degeneration0.49086156
89MP0002080_prenatal_lethality0.49072298
90MP0000703_abnormal_thymus_morphology0.48134375
91MP0010771_integument_phenotype0.47640674
92MP0005647_abnormal_sex_gland0.47248641
93MP0005646_abnormal_pituitary_gland0.47213579
94MP0002075_abnormal_coat/hair_pigmentati0.46912198
95MP0002060_abnormal_skin_morphology0.46123720
96MP0003172_abnormal_lysosome_physiology0.46108802
97MP0000371_diluted_coat_color0.45591154
98MP0009697_abnormal_copulation0.45315277
99MP0002009_preneoplasia0.44242025
100MP0000631_abnormal_neuroendocrine_gland0.43284666

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)6.90244855
2Horizontal nystagmus (HP:0000666)6.73620774
3Abnormal protein glycosylation (HP:0012346)6.26539308
4Abnormal glycosylation (HP:0012345)6.26539308
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)6.26539308
6Abnormal protein N-linked glycosylation (HP:0012347)6.26539308
7Shoulder girdle muscle weakness (HP:0003547)6.25670556
8Amyotrophic lateral sclerosis (HP:0007354)5.61415672
9Rimmed vacuoles (HP:0003805)5.58641863
10Abnormality of the lower motor neuron (HP:0002366)5.24460859
11Volvulus (HP:0002580)5.24183220
12Upper motor neuron abnormality (HP:0002127)4.76863148
1311 pairs of ribs (HP:0000878)4.51705113
14Gonadotropin excess (HP:0000837)4.37805485
15Oligodactyly (hands) (HP:0001180)4.32189106
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.75905024
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.75905024
18Large hands (HP:0001176)3.75878616
19Osteomalacia (HP:0002749)3.45221396
20Facial hemangioma (HP:0000329)3.38586323
21Azoospermia (HP:0000027)3.37339491
22Increased nuchal translucency (HP:0010880)3.29335926
23Atrophy/Degeneration involving motor neurons (HP:0007373)3.24143633
24Hypoplastic iliac wings (HP:0002866)3.20309331
25Metaphyseal cupping (HP:0003021)3.15921910
26Aplasia/Hypoplasia of the sternum (HP:0006714)3.14195443
27Broad distal phalanx of finger (HP:0009836)3.10186428
28Short nail (HP:0001799)3.09194129
29Abnormality of the vocal cords (HP:0008777)3.07982124
30Tubulointerstitial nephritis (HP:0001970)3.03087088
31Non-midline cleft lip (HP:0100335)2.86704112
32Oligodactyly (HP:0012165)2.79123347
33Ectopic kidney (HP:0000086)2.76914475
34Abnormality of the corticospinal tract (HP:0002492)2.68799072
35Abnormality of cochlea (HP:0000375)2.67442180
36Spontaneous abortion (HP:0005268)2.66436061
37Chromsome breakage (HP:0040012)2.57457909
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55906838
39Capillary hemangiomas (HP:0005306)2.51156140
40Limb-girdle muscle weakness (HP:0003325)2.48125469
41Abnormality of DNA repair (HP:0003254)2.45633154
42Abnormality of chromosome segregation (HP:0002916)2.33338410
43Abnormal spermatogenesis (HP:0008669)2.20587172
44Abnormality of the calcaneus (HP:0008364)2.14695781
45Abnormality of the renal medulla (HP:0100957)2.13301707
46Missing ribs (HP:0000921)2.12181658
47Bicuspid aortic valve (HP:0001647)2.11570927
48Poor coordination (HP:0002370)2.10281290
49Widely spaced teeth (HP:0000687)2.10043622
50Small intestinal stenosis (HP:0012848)2.07045576
51Duodenal stenosis (HP:0100867)2.07045576
52Rhizomelia (HP:0008905)2.05738711
53Synophrys (HP:0000664)2.05393039
54Hyperkalemia (HP:0002153)2.03847339
55Aplasia/Hypoplasia of the earlobes (HP:0009906)2.03363262
56Proximal placement of thumb (HP:0009623)2.03001556
57Nephronophthisis (HP:0000090)2.02905010
58Truncal obesity (HP:0001956)1.98973484
59Low posterior hairline (HP:0002162)1.98599150
60Congenital primary aphakia (HP:0007707)1.97498341
61Lip pit (HP:0100267)1.95926900
62Resting tremor (HP:0002322)1.95644192
63Bowel incontinence (HP:0002607)1.95564526
64Blepharitis (HP:0000498)1.94859270
65Morphological abnormality of the inner ear (HP:0011390)1.93767148
66Gait imbalance (HP:0002141)1.90765717
67Abnormality of the motor neurons (HP:0002450)1.89883763
68Abnormal neuron morphology (HP:0012757)1.89883763
69Impaired vibration sensation in the lower limbs (HP:0002166)1.89253230
70Abnormal large intestine physiology (HP:0012700)1.87732972
71Nephroblastoma (Wilms tumor) (HP:0002667)1.87060920
72Preaxial hand polydactyly (HP:0001177)1.86668216
73Multicystic kidney dysplasia (HP:0000003)1.85244618
74Abnormality of chloride homeostasis (HP:0011422)1.84365142
75Urinary urgency (HP:0000012)1.83818059
76Abnormality of the dental root (HP:0006486)1.82010638
77Taurodontia (HP:0000679)1.82010638
78Abnormality of permanent molar morphology (HP:0011071)1.82010638
79Abnormality of chromosome stability (HP:0003220)1.81567673
80Scotoma (HP:0000575)1.78143137
81Embryonal renal neoplasm (HP:0011794)1.78040939
82Deviation of the thumb (HP:0009603)1.77424463
83Hypoplastic labia majora (HP:0000059)1.77063553
84Medial flaring of the eyebrow (HP:0010747)1.73544120
85Fetal akinesia sequence (HP:0001989)1.73407673
86Supernumerary spleens (HP:0009799)1.71751848
87Fragile nails (HP:0001808)1.71689060
88Nephrogenic diabetes insipidus (HP:0009806)1.71381642
89Bulbar palsy (HP:0001283)1.71312629
90Atelectasis (HP:0100750)1.70437680
91Intellectual disability, moderate (HP:0002342)1.69922741
92Thin ribs (HP:0000883)1.69158659
93Short middle phalanx of the 5th finger (HP:0004220)1.68259265
94Hypoplastic ilia (HP:0000946)1.68065628
95Decreased subcutaneous fat (HP:0001002)1.67352329
96Abnormality of molar morphology (HP:0011070)1.63797778
97Abnormality of molar (HP:0011077)1.63797778
98Obsessive-compulsive behavior (HP:0000722)1.63703799
99Acanthocytosis (HP:0001927)1.63643234
100Rhabdomyosarcoma (HP:0002859)1.63099555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET6.15361801
2BMX4.15769163
3CAMK1G4.06338149
4PTK2B3.77973428
5CDK193.63761758
6FGR3.63756449
7CSF1R3.03361782
8PLK22.07200041
9PNCK10.5669279
10RET1.94114763
11PDGFRB1.84601280
12OXSR11.74365450
13NEK11.72014671
14PLK41.68063745
15MAP3K101.49159294
16PTK21.23074328
17CASK1.21155627
18PDK21.14898920
19MAP3K21.08378235
20YES10.98503301
21MST1R0.97508335
22TTK0.90899871
23WEE10.90844514
24TSSK60.86809666
25PRKCI0.86059847
26ATR0.78975459
27KSR10.71407847
28MAP3K90.71346547
29EGFR0.69639357
30CHEK10.69631181
31CDK60.68707662
32NEK90.65635891
33NEK20.65300370
34KSR20.63042906
35SGK10.61731726
36PLK10.61117551
37RAF10.60024223
38TAF10.56554172
39ROCK10.55520833
40CAMK10.54136608
41MAP3K40.52856974
42TYRO30.51230209
43RPS6KB10.50570540
44PASK0.48573581
45PINK10.46258794
46ATM0.45180645
47MAP2K20.42691023
48CDK11A0.40759800
49STK38L0.40569384
50CDK30.40531712
51CDK70.39925305
52CDK40.38329248
53STK380.38088331
54NUAK10.36793020
55NEK60.34946091
56BRAF0.34296708
57ARAF0.33274588
58CDK120.32669702
59STK110.32486178
60MAPK130.32279262
61WNK10.30870182
62MARK30.30060139
63CSNK1E0.28786564
64CDK50.27517869
65CCNB10.26476826
66PTK60.26466696
67NTRK30.25899365
68MAP3K130.25244214
69CDK10.23467456
70CHEK20.23346756
71LATS10.22935783
72SRPK10.22620950
73PDPK10.21378275
74CDK20.21370422
75MAP3K50.20334052
76IGF1R0.17684372
77PDK10.16487409
78MAPK100.16266052
79AURKA0.15074201
80NLK0.14350046
81DYRK30.14345573
82EPHA40.13433584
83MAPK30.13094369
84PRKAA10.12345358
85MAPK10.12157004
86PIM10.11768677
87PRKDC0.11279518
88MINK10.08566387
89BRSK10.08145830
90MTOR0.07638148
91GSK3B0.06035254
92PRPF4B0.05680726
93CSNK2A10.04704448
94TAOK20.04487317
95MAPK140.04335572
96RPS6KA50.04013561
97JAK20.03799702
98ADRBK10.03113690
99PRKG10.03074422
100CSNK2A20.02383451

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.20741425
2Mismatch repair_Homo sapiens_hsa034303.79223592
3Fanconi anemia pathway_Homo sapiens_hsa034603.70923122
4DNA replication_Homo sapiens_hsa030303.62745468
5Ubiquitin mediated proteolysis_Homo sapiens_hsa041203.31875063
6RNA transport_Homo sapiens_hsa030133.30608871
7N-Glycan biosynthesis_Homo sapiens_hsa005103.22880734
8Cell cycle_Homo sapiens_hsa041103.21362828
9Nucleotide excision repair_Homo sapiens_hsa034203.05507552
10Regulation of autophagy_Homo sapiens_hsa041403.04348053
11mRNA surveillance pathway_Homo sapiens_hsa030152.83839611
12Oocyte meiosis_Homo sapiens_hsa041142.75827475
13RNA degradation_Homo sapiens_hsa030182.50458271
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.42968381
15ErbB signaling pathway_Homo sapiens_hsa040122.40209741
16Base excision repair_Homo sapiens_hsa034102.06997834
17Basal transcription factors_Homo sapiens_hsa030222.00609543
18Small cell lung cancer_Homo sapiens_hsa052221.88673267
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74012649
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59384624
21Lysine degradation_Homo sapiens_hsa003101.58416389
22Dorso-ventral axis formation_Homo sapiens_hsa043201.54146614
23Sulfur relay system_Homo sapiens_hsa041221.48456086
24VEGF signaling pathway_Homo sapiens_hsa043701.46901394
25mTOR signaling pathway_Homo sapiens_hsa041501.31226093
26Selenocompound metabolism_Homo sapiens_hsa004501.28829059
27Fatty acid biosynthesis_Homo sapiens_hsa000611.25898820
28Non-homologous end-joining_Homo sapiens_hsa034501.22607895
29Choline metabolism in cancer_Homo sapiens_hsa052311.19134553
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13267211
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06346448
32Spliceosome_Homo sapiens_hsa030401.02653809
33Chronic myeloid leukemia_Homo sapiens_hsa052200.90094651
34Prostate cancer_Homo sapiens_hsa052150.84709180
35Shigellosis_Homo sapiens_hsa051310.76897478
36Adipocytokine signaling pathway_Homo sapiens_hsa049200.76745563
37Pyruvate metabolism_Homo sapiens_hsa006200.74436885
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71562089
39Acute myeloid leukemia_Homo sapiens_hsa052210.69674534
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69299671
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66137320
42Type II diabetes mellitus_Homo sapiens_hsa049300.64886854
43Linoleic acid metabolism_Homo sapiens_hsa005910.64550530
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63439772
45Fatty acid metabolism_Homo sapiens_hsa012120.60678106
46One carbon pool by folate_Homo sapiens_hsa006700.60218526
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60038145
48p53 signaling pathway_Homo sapiens_hsa041150.58734639
49Adherens junction_Homo sapiens_hsa045200.58604258
50Steroid biosynthesis_Homo sapiens_hsa001000.58277524
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57643502
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54924521
53MAPK signaling pathway_Homo sapiens_hsa040100.53547706
54Ether lipid metabolism_Homo sapiens_hsa005650.53014558
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.52443837
56Viral carcinogenesis_Homo sapiens_hsa052030.51971619
57Non-small cell lung cancer_Homo sapiens_hsa052230.50329656
58Propanoate metabolism_Homo sapiens_hsa006400.50198225
59Phenylalanine metabolism_Homo sapiens_hsa003600.50111994
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49745276
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48886522
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.44409974
63Amoebiasis_Homo sapiens_hsa051460.43199795
64Fat digestion and absorption_Homo sapiens_hsa049750.42391671
65Pyrimidine metabolism_Homo sapiens_hsa002400.41980588
66Insulin signaling pathway_Homo sapiens_hsa049100.39214827
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38873791
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.38729593
69Endometrial cancer_Homo sapiens_hsa052130.38434910
70Glioma_Homo sapiens_hsa052140.37988364
71AMPK signaling pathway_Homo sapiens_hsa041520.37369705
72HTLV-I infection_Homo sapiens_hsa051660.36988880
73Huntingtons disease_Homo sapiens_hsa050160.36490101
74Legionellosis_Homo sapiens_hsa051340.35928588
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35030887
76Retinol metabolism_Homo sapiens_hsa008300.34949682
77Olfactory transduction_Homo sapiens_hsa047400.34027835
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33252298
79Antigen processing and presentation_Homo sapiens_hsa046120.32765675
80Calcium signaling pathway_Homo sapiens_hsa040200.32587331
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30068336
82Estrogen signaling pathway_Homo sapiens_hsa049150.28479094
83Prolactin signaling pathway_Homo sapiens_hsa049170.27823229
84Focal adhesion_Homo sapiens_hsa045100.25362664
85Pathways in cancer_Homo sapiens_hsa052000.25251380
86Herpes simplex infection_Homo sapiens_hsa051680.24987061
87Taste transduction_Homo sapiens_hsa047420.24894112
88Vitamin digestion and absorption_Homo sapiens_hsa049770.24578661
89Inositol phosphate metabolism_Homo sapiens_hsa005620.23430862
90Pancreatic cancer_Homo sapiens_hsa052120.22496315
91Epstein-Barr virus infection_Homo sapiens_hsa051690.18058158
92ABC transporters_Homo sapiens_hsa020100.16615564
93Purine metabolism_Homo sapiens_hsa002300.16356804
94Insulin resistance_Homo sapiens_hsa049310.16138206
95Axon guidance_Homo sapiens_hsa043600.16081228
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15634065
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.14916227
98Renal cell carcinoma_Homo sapiens_hsa052110.14284081
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14052178
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.13150136

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