TSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.26015885
2establishment of integrated proviral latency (GO:0075713)5.23585500
3nuclear pore complex assembly (GO:0051292)5.01673024
4IMP biosynthetic process (GO:0006188)4.91766683
5folic acid-containing compound biosynthetic process (GO:0009396)4.87602985
6nucleobase biosynthetic process (GO:0046112)4.85926999
7protein localization to kinetochore (GO:0034501)4.67005465
8DNA unwinding involved in DNA replication (GO:0006268)4.65979221
9mitotic nuclear envelope disassembly (GO:0007077)4.56431239
10purine nucleobase biosynthetic process (GO:0009113)4.47552270
11formation of translation preinitiation complex (GO:0001731)4.45036638
12DNA replication initiation (GO:0006270)4.42500979
13maturation of SSU-rRNA (GO:0030490)4.41631507
14nuclear envelope disassembly (GO:0051081)4.28075745
15membrane disassembly (GO:0030397)4.28075745
16IMP metabolic process (GO:0046040)4.26735133
17mitotic metaphase plate congression (GO:0007080)4.22035721
18DNA replication-dependent nucleosome assembly (GO:0006335)4.19471681
19DNA replication-dependent nucleosome organization (GO:0034723)4.19471681
20DNA strand elongation involved in DNA replication (GO:0006271)4.11551654
21* ribosome assembly (GO:0042255)4.06872340
22DNA replication checkpoint (GO:0000076)4.03385359
23establishment of viral latency (GO:0019043)4.01085416
24* ribosome biogenesis (GO:0042254)3.96583558
25DNA strand elongation (GO:0022616)3.88938247
26L-serine metabolic process (GO:0006563)3.82017108
27protein localization to chromosome, centromeric region (GO:0071459)3.81956892
28regulation of translational termination (GO:0006449)3.81462936
29pore complex assembly (GO:0046931)3.76299272
30protein complex localization (GO:0031503)3.73427811
31DNA duplex unwinding (GO:0032508)3.70762910
32DNA geometric change (GO:0032392)3.69480570
33regulation of spindle organization (GO:0090224)3.68234916
34non-recombinational repair (GO:0000726)3.67966673
35double-strand break repair via nonhomologous end joining (GO:0006303)3.67966673
36telomere maintenance via semi-conservative replication (GO:0032201)3.60391878
37metaphase plate congression (GO:0051310)3.60366417
38pre-miRNA processing (GO:0031054)3.45478559
39regulation of gene silencing by RNA (GO:0060966)3.45128912
40regulation of posttranscriptional gene silencing (GO:0060147)3.45128912
41regulation of gene silencing by miRNA (GO:0060964)3.45128912
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.44236205
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44236205
44* ribonucleoprotein complex biogenesis (GO:0022613)3.44180801
45ribosomal large subunit biogenesis (GO:0042273)3.42267797
46regulation of translational fidelity (GO:0006450)3.40353580
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39289186
48heterochromatin organization (GO:0070828)3.38877968
49DNA ligation (GO:0006266)3.38749799
50chromatin remodeling at centromere (GO:0031055)3.35393222
51nuclear envelope organization (GO:0006998)3.33986699
52cellular protein complex localization (GO:0034629)3.33916901
53rRNA processing (GO:0006364)3.30720413
54folic acid metabolic process (GO:0046655)3.30587618
55positive regulation of chromosome segregation (GO:0051984)3.28704146
56CENP-A containing nucleosome assembly (GO:0034080)3.26644128
57regulation of centriole replication (GO:0046599)3.26017061
58telomere maintenance via recombination (GO:0000722)3.25809266
59mitotic sister chromatid segregation (GO:0000070)3.23182523
60DNA replication-independent nucleosome organization (GO:0034724)3.22459659
61DNA replication-independent nucleosome assembly (GO:0006336)3.22459659
62DNA topological change (GO:0006265)3.22340357
63mitotic chromosome condensation (GO:0007076)3.22193110
64rRNA metabolic process (GO:0016072)3.21748031
65ribosomal small subunit assembly (GO:0000028)3.20010900
66regulation of helicase activity (GO:0051095)3.19236389
67mitotic recombination (GO:0006312)3.17976520
68telomere maintenance via telomere lengthening (GO:0010833)3.17946041
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17920699
70attachment of spindle microtubules to kinetochore (GO:0008608)3.17268110
71negative regulation of mRNA processing (GO:0050686)3.17228433
72regulation of mitotic spindle organization (GO:0060236)3.16579653
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15311877
74establishment of chromosome localization (GO:0051303)3.14267742
75spliceosomal snRNP assembly (GO:0000387)3.12544317
76sister chromatid segregation (GO:0000819)3.10544497
77regulation of centrosome cycle (GO:0046605)3.09769526
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.06446054
79tRNA aminoacylation for protein translation (GO:0006418)3.06244537
80negative regulation of histone methylation (GO:0031061)3.05873746
81nucleobase-containing small molecule interconversion (GO:0015949)3.05798502
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03007318
83chromatin assembly or disassembly (GO:0006333)3.02999643
84mitotic spindle assembly checkpoint (GO:0007094)3.00732043
85regulation of histone H3-K9 methylation (GO:0051570)2.99672265
86mitotic sister chromatid cohesion (GO:0007064)2.99540064
87chromosome condensation (GO:0030261)2.99102769
88negative regulation of mRNA metabolic process (GO:1903312)2.98976867
89histone H2A monoubiquitination (GO:0035518)2.98676388
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97570783
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97179949
92kinetochore organization (GO:0051383)2.95514255
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95212338
94tRNA aminoacylation (GO:0043039)2.94992246
95amino acid activation (GO:0043038)2.94992246
96negative regulation of RNA splicing (GO:0033119)2.94684118
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94364199
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.93894252
99protein localization to chromosome (GO:0034502)2.93777444
100regulation of RNA export from nucleus (GO:0046831)2.93626747
101translational initiation (GO:0006413)2.93170773
102mitochondrial RNA metabolic process (GO:0000959)2.92970484
103spindle checkpoint (GO:0031577)2.92947007
104regulation of sister chromatid segregation (GO:0033045)2.92005503
105regulation of mitotic sister chromatid separation (GO:0010965)2.92005503
106regulation of mitotic sister chromatid segregation (GO:0033047)2.92005503
107regulation of chromosome segregation (GO:0051983)2.91418569
108mRNA transport (GO:0051028)2.91290223
109peptidyl-arginine omega-N-methylation (GO:0035247)2.91136278
110DNA conformation change (GO:0071103)2.90754462
111negative regulation of chromosome segregation (GO:0051985)2.89377594
112histone exchange (GO:0043486)2.88979940
113chromatin assembly (GO:0031497)2.86990529
114maturation of 5.8S rRNA (GO:0000460)2.86662751
115RNA splicing, via transesterification reactions (GO:0000375)2.86506174
116spindle assembly checkpoint (GO:0071173)2.85463216
117chaperone-mediated protein complex assembly (GO:0051131)2.85225743
118RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84868914
119mRNA splicing, via spliceosome (GO:0000398)2.84868914
120postreplication repair (GO:0006301)2.84629786
121regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84618219
122histone-serine phosphorylation (GO:0035404)2.84009161
123negative regulation of mitotic sister chromatid separation (GO:2000816)2.83893383
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83893383
125negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83893383
126negative regulation of sister chromatid segregation (GO:0033046)2.83893383
127mitotic spindle checkpoint (GO:0071174)2.82788438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.77892332
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.46807797
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97849567
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60112846
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50567637
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21736452
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90647412
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87417384
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65766769
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.62166394
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.56788496
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55348758
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.50647379
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45917556
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40071066
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39093014
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.35870134
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34652362
19XRN2_22483619_ChIP-Seq_HELA_Human2.25740657
20AR_21909140_ChIP-Seq_LNCAP_Human2.21178927
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14316689
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.11786901
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07389306
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04266158
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03109568
26VDR_23849224_ChIP-Seq_CD4+_Human2.00725666
27MYC_22102868_ChIP-Seq_BL_Human1.98924743
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.95540504
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92465968
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85500526
31FOXP3_21729870_ChIP-Seq_TREG_Human1.81123988
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79440411
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77554344
34* GABP_19822575_ChIP-Seq_HepG2_Human1.77244242
35DCP1A_22483619_ChIP-Seq_HELA_Human1.75383817
36TTF2_22483619_ChIP-Seq_HELA_Human1.69822922
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68985537
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67748338
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66619919
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66039688
41ELK1_19687146_ChIP-ChIP_HELA_Human1.64075193
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61181106
43* KDM5A_27292631_Chip-Seq_BREAST_Human1.59820387
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55189645
45CIITA_25753668_ChIP-Seq_RAJI_Human1.54094139
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52984578
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46237612
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42746541
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42563804
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.42226624
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39348071
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37143782
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36950252
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36327388
55TFEB_21752829_ChIP-Seq_HELA_Human1.33136222
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33057922
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32385057
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31460198
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30961969
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29284215
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27815462
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.23901644
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23882807
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22952727
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21932692
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21820313
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.21384131
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21200756
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20852897
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18570147
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18544059
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18221414
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15770266
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15446343
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13440961
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12987393
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.10845058
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.10144613
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09079007
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08212838
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05334809
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04468736
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04457534
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03135849
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02982563
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02708439
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02708439
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02708439
89* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02174831
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.01804902
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01621635
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01040838
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99813306
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.98013001
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97848082
96MYC_18940864_ChIP-ChIP_HL60_Human0.96179050
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93222839
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.90284692
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88241012
100* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86384201
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85599502
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85263284
103CHD1_26751641_Chip-Seq_LNCaP_Human0.85170421
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83800056
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83513261
106TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83003970
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82754985
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.81962271
109ZNF263_19887448_ChIP-Seq_K562_Human0.80816606
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80134548
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79990188
112CLOCK_20551151_ChIP-Seq_293T_Human0.79626542
113* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79081335
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77775104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.07568199
2MP0010094_abnormal_chromosome_stability4.49991839
3MP0004957_abnormal_blastocyst_morpholog4.47228446
4MP0003111_abnormal_nucleus_morphology4.36209040
5MP0003077_abnormal_cell_cycle3.86704729
6MP0008057_abnormal_DNA_replication3.81329784
7MP0010352_gastrointestinal_tract_polyps3.22600368
8MP0003123_paternal_imprinting3.08562965
9MP0008058_abnormal_DNA_repair3.06034031
10MP0001730_embryonic_growth_arrest2.79804739
11MP0008007_abnormal_cellular_replicative2.73210401
12MP0010307_abnormal_tumor_latency2.53454478
13MP0000350_abnormal_cell_proliferation2.49235736
14MP0008932_abnormal_embryonic_tissue2.36903456
15MP0002396_abnormal_hematopoietic_system2.26015773
16MP0001672_abnormal_embryogenesis/_devel2.14654112
17MP0005380_embryogenesis_phenotype2.14654112
18MP0008877_abnormal_DNA_methylation2.02181080
19MP0001697_abnormal_embryo_size2.01879436
20MP0003984_embryonic_growth_retardation1.98396291
21MP0002088_abnormal_embryonic_growth/wei1.94640120
22MP0002084_abnormal_developmental_patter1.87701368
23MP0004197_abnormal_fetal_growth/weight/1.86138304
24MP0002086_abnormal_extraembryonic_tissu1.84401236
25MP0002080_prenatal_lethality1.83208114
26MP0003786_premature_aging1.82050923
27MP0005076_abnormal_cell_differentiation1.80355687
28MP0002085_abnormal_embryonic_tissue1.75246656
29MP0003806_abnormal_nucleotide_metabolis1.74699186
30MP0003890_abnormal_embryonic-extraembry1.70691575
31MP0003705_abnormal_hypodermis_morpholog1.70619307
32MP0009697_abnormal_copulation1.63717356
33MP0003121_genomic_imprinting1.51162212
34MP0003567_abnormal_fetal_cardiomyocyte1.47541139
35MP0004808_abnormal_hematopoietic_stem1.47191828
36MP0000537_abnormal_urethra_morphology1.46945867
37MP0000490_abnormal_crypts_of1.43980243
38MP0000313_abnormal_cell_death1.40744771
39MP0004264_abnormal_extraembryonic_tissu1.37687823
40MP0002019_abnormal_tumor_incidence1.36801387
41MP0000579_abnormal_nail_morphology1.35774672
42MP0001661_extended_life_span1.33115790
43MP0002796_impaired_skin_barrier1.31905966
44MP0001293_anophthalmia1.28882855
45MP0003566_abnormal_cell_adhesion1.26957784
46MP0003119_abnormal_digestive_system1.26723773
47MP0005501_abnormal_skin_physiology1.24371710
48MP0003718_maternal_effect1.22270589
49MP0006035_abnormal_mitochondrial_morpho1.22076646
50MP0009672_abnormal_birth_weight1.19952080
51MP0002877_abnormal_melanocyte_morpholog1.19903664
52MP0005623_abnormal_meninges_morphology1.15297153
53MP0004185_abnormal_adipocyte_glucose1.14338422
54MP0010234_abnormal_vibrissa_follicle1.12987077
55MP0010030_abnormal_orbit_morphology1.10744583
56MP0005023_abnormal_wound_healing1.08502959
57MP0009053_abnormal_anal_canal1.05383426
58MP0000762_abnormal_tongue_morphology1.04788114
59MP0003941_abnormal_skin_development1.01795150
60MP0002210_abnormal_sex_determination1.01299776
61MP0004272_abnormal_basement_membrane1.00711575
62MP0009333_abnormal_splenocyte_physiolog0.98698711
63MP0000358_abnormal_cell_content/0.98424756
64MP0000703_abnormal_thymus_morphology0.98107119
65MP0001145_abnormal_male_reproductive0.97524824
66MP0005384_cellular_phenotype0.96090270
67MP0002060_abnormal_skin_morphology0.94766499
68MP0006054_spinal_hemorrhage0.94330529
69MP0003950_abnormal_plasma_membrane0.94276899
70MP0005621_abnormal_cell_physiology0.93981470
71MP0009703_decreased_birth_body0.93427880
72MP0000428_abnormal_craniofacial_morphol0.91809769
73MP0003763_abnormal_thymus_physiology0.90050923
74MP0005451_abnormal_body_composition0.89810341
75MP0002111_abnormal_tail_morphology0.89009324
76MP0001915_intracranial_hemorrhage0.88888618
77MP0001545_abnormal_hematopoietic_system0.87340368
78MP0005397_hematopoietic_system_phenotyp0.87340368
79MP0001346_abnormal_lacrimal_gland0.87167385
80MP0004133_heterotaxia0.85655141
81MP0004233_abnormal_muscle_weight0.85284613
82MP0002160_abnormal_reproductive_system0.85110083
83MP0003283_abnormal_digestive_organ0.84706202
84MP0001727_abnormal_embryo_implantation0.80039635
85MP0000749_muscle_degeneration0.78750968
86MP0000653_abnormal_sex_gland0.78180537
87MP0003221_abnormal_cardiomyocyte_apopto0.77377928
88MP0002398_abnormal_bone_marrow0.77169894
89MP0000858_altered_metastatic_potential0.76526132
90MP0003755_abnormal_palate_morphology0.76020761
91MP0002269_muscular_atrophy0.75675073
92MP0002722_abnormal_immune_system0.75575534
93MP0001299_abnormal_eye_distance/0.74261381
94MP0001929_abnormal_gametogenesis0.74236955
95MP0003937_abnormal_limbs/digits/tail_de0.73720924
96MP0003385_abnormal_body_wall0.73582064
97MP0002092_abnormal_eye_morphology0.73221406
98MP0000751_myopathy0.73216282
99MP0001849_ear_inflammation0.72664788
100MP0008770_decreased_survivor_rate0.72188553
101MP0000689_abnormal_spleen_morphology0.71497149
102MP0000733_abnormal_muscle_development0.71024515
103MP0006036_abnormal_mitochondrial_physio0.70352373
104MP0000477_abnormal_intestine_morphology0.69998272
105MP0002254_reproductive_system_inflammat0.69768700
106MP0002233_abnormal_nose_morphology0.68564630
107MP0006292_abnormal_olfactory_placode0.67089488
108MP0005389_reproductive_system_phenotype0.66260250
109MP0001216_abnormal_epidermal_layer0.65900460
110MP0003186_abnormal_redox_activity0.65241987
111MP0003861_abnormal_nervous_system0.64544284
112MP0000432_abnormal_head_morphology0.62996118
113MP0002009_preneoplasia0.61626900
114MP0004087_abnormal_muscle_fiber0.61431263
115MP0000747_muscle_weakness0.61237557
116MP0002925_abnormal_cardiovascular_devel0.61120824
117MP0005330_cardiomyopathy0.60328533
118MP0001286_abnormal_eye_development0.59623372
119MP0002653_abnormal_ependyma_morphology0.59306291
120MP0003115_abnormal_respiratory_system0.59296275
121MP0001119_abnormal_female_reproductive0.58886435
122MP0003315_abnormal_perineum_morphology0.58107602
123MP0003935_abnormal_craniofacial_develop0.57730721
124MP0002697_abnormal_eye_size0.55615831
125MP0000750_abnormal_muscle_regeneration0.55520798
126MP0000627_abnormal_mammary_gland0.53811938
127MP0005367_renal/urinary_system_phenotyp0.53540070
128MP0000516_abnormal_urinary_system0.53540070
129MP0002429_abnormal_blood_cell0.53086855
130MP0005266_abnormal_metabolism0.52483286
131MP0000266_abnormal_heart_morphology0.50892442

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.68581916
2Ependymoma (HP:0002888)4.24365461
3Colon cancer (HP:0003003)3.47768761
4Selective tooth agenesis (HP:0001592)3.45131985
5Chromsome breakage (HP:0040012)3.42299051
6Medulloblastoma (HP:0002885)3.36300336
7Breast hypoplasia (HP:0003187)3.25373333
8Abnormality of the labia minora (HP:0012880)3.15206870
9Degeneration of anterior horn cells (HP:0002398)3.14406315
10Abnormality of the anterior horn cell (HP:0006802)3.14406315
11Microvesicular hepatic steatosis (HP:0001414)3.11857380
12Abnormality of glycolysis (HP:0004366)3.09557277
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07216887
14Agnosia (HP:0010524)3.03886874
15Reticulocytopenia (HP:0001896)3.02304446
16Progressive muscle weakness (HP:0003323)2.98096221
17Astrocytoma (HP:0009592)2.94173048
18Abnormality of the astrocytes (HP:0100707)2.94173048
19Abnormality of chromosome stability (HP:0003220)2.88637989
20Rhabdomyosarcoma (HP:0002859)2.87054815
21Carpal bone hypoplasia (HP:0001498)2.86241414
22Increased serum pyruvate (HP:0003542)2.81741568
23Impulsivity (HP:0100710)2.81177380
24Patellar aplasia (HP:0006443)2.78443929
25Oral leukoplakia (HP:0002745)2.71867758
26Basal cell carcinoma (HP:0002671)2.70999177
27Nephroblastoma (Wilms tumor) (HP:0002667)2.68641264
28Missing ribs (HP:0000921)2.66071537
29Biliary tract neoplasm (HP:0100574)2.63478910
30Glioma (HP:0009733)2.62407251
31Meckel diverticulum (HP:0002245)2.62339100
32Spastic diplegia (HP:0001264)2.61020165
33Aplasia/Hypoplasia of the patella (HP:0006498)2.60502328
34Myelodysplasia (HP:0002863)2.57495320
35Cortical dysplasia (HP:0002539)2.57227546
36Abnormality of the preputium (HP:0100587)2.56407524
37Embryonal renal neoplasm (HP:0011794)2.53365894
38Progressive external ophthalmoplegia (HP:0000590)2.52405780
39Rough bone trabeculation (HP:0100670)2.50737087
40Absent thumb (HP:0009777)2.49810894
41Abnormality of the ileum (HP:0001549)2.49713686
42Absent radius (HP:0003974)2.49580370
4311 pairs of ribs (HP:0000878)2.48673882
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.42497437
45Amaurosis fugax (HP:0100576)2.41984113
46Trismus (HP:0000211)2.41238927
47Neoplasm of the pancreas (HP:0002894)2.40182801
48Cutaneous melanoma (HP:0012056)2.39773133
49Multiple enchondromatosis (HP:0005701)2.39220191
50Deviation of the thumb (HP:0009603)2.38802008
51Neoplasm of the oral cavity (HP:0100649)2.38552880
52Abnormality of the calcaneus (HP:0008364)2.29799775
53Aplasia involving forearm bones (HP:0009822)2.27807555
54Absent forearm bone (HP:0003953)2.27807555
55Proximal placement of thumb (HP:0009623)2.27359400
56Abnormal lung lobation (HP:0002101)2.25680670
57Pelvic girdle muscle weakness (HP:0003749)2.18490843
58Duodenal stenosis (HP:0100867)2.16895003
59Small intestinal stenosis (HP:0012848)2.16895003
60Cerebral hypomyelination (HP:0006808)2.15588719
61Prominent nose (HP:0000448)2.15572077
62Cafe-au-lait spot (HP:0000957)2.14937947
63Increased nuchal translucency (HP:0010880)2.14561041
64Aplastic anemia (HP:0001915)2.14496943
65Neoplasm of striated muscle (HP:0009728)2.12587960
66Ectopic kidney (HP:0000086)2.12307702
67Thrombocytosis (HP:0001894)2.12169313
68Squamous cell carcinoma (HP:0002860)2.11331050
69Abnormality of cells of the erythroid lineage (HP:0012130)2.10835058
70Premature graying of hair (HP:0002216)2.10154350
71Aplasia/hypoplasia of the humerus (HP:0006507)2.08705977
72Horseshoe kidney (HP:0000085)2.07771051
73Abnormal biliary tract morphology (HP:0012440)2.07674051
74Spinal muscular atrophy (HP:0007269)2.07266308
75Facial cleft (HP:0002006)2.06619634
76Abnormality of the umbilical cord (HP:0010881)2.03061628
77Sloping forehead (HP:0000340)2.02898778
78Bone marrow hypocellularity (HP:0005528)2.01381768
79Atresia of the external auditory canal (HP:0000413)2.00119657
80Calcaneovalgus deformity (HP:0001848)2.00049645
81Abnormality of methionine metabolism (HP:0010901)1.99021414
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.98107631
83Glossoptosis (HP:0000162)1.97911843
84Secondary amenorrhea (HP:0000869)1.97598373
85Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97598016
86Overlapping toe (HP:0001845)1.97169744
87Slender long bone (HP:0003100)1.95817552
88Abnormality of the carotid arteries (HP:0005344)1.94327314
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94285362
90Freckling (HP:0001480)1.94281735
91Ureteral duplication (HP:0000073)1.92507326
92Adenoma sebaceum (HP:0009720)1.91812377
93Angiofibromas (HP:0010615)1.91812377
94Entropion (HP:0000621)1.90787809
95Atrophy/Degeneration involving motor neurons (HP:0007373)1.89838771
96Tracheoesophageal fistula (HP:0002575)1.88427479
97Volvulus (HP:0002580)1.88146306
98Short humerus (HP:0005792)1.87287077
99Choanal atresia (HP:0000453)1.87279523
100Shoulder girdle muscle weakness (HP:0003547)1.86984311
101Abnormal number of erythroid precursors (HP:0012131)1.86645974
102Metaphyseal cupping (HP:0003021)1.86590102
103Gastrointestinal carcinoma (HP:0002672)1.84884850
104Malignant gastrointestinal tract tumors (HP:0006749)1.84884850
105Postnatal microcephaly (HP:0005484)1.84295261
106Hyperacusis (HP:0010780)1.83778405
107Neoplasm of the colon (HP:0100273)1.83274344
108Supernumerary spleens (HP:0009799)1.83176236
109Abnormality of the duodenum (HP:0002246)1.83073732
110Hypoplasia of the pons (HP:0012110)1.82756449
111Cellular immunodeficiency (HP:0005374)1.82640553
112Premature ovarian failure (HP:0008209)1.79506432
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78202196
114Poikiloderma (HP:0001029)1.78136544
115Neoplasm of the rectum (HP:0100743)1.77914286
116Sparse lateral eyebrow (HP:0005338)1.76270776
117Abnormal number of incisors (HP:0011064)1.75790015
118Abnormalities of placenta or umbilical cord (HP:0001194)1.75664610
119Prominent metopic ridge (HP:0005487)1.73103599
120Abnormality of the musculature of the pelvis (HP:0001469)1.72959343
121Abnormality of the hip-girdle musculature (HP:0001445)1.72959343
122Ovarian neoplasm (HP:0100615)1.72525144
123Ragged-red muscle fibers (HP:0003200)1.72388238
124Insomnia (HP:0100785)1.72269262
125Reduced antithrombin III activity (HP:0001976)1.69795383
126Pancreatic islet-cell hyperplasia (HP:0004510)1.69238324
127Microglossia (HP:0000171)1.68620683
128Exercise-induced muscle cramps (HP:0003710)1.68208478
129Sparse eyelashes (HP:0000653)1.68065202
130Deformed tarsal bones (HP:0008119)1.65537493
131Sensory axonal neuropathy (HP:0003390)1.64277614
132High anterior hairline (HP:0009890)1.63230132
133Neuroblastoma (HP:0003006)1.60777091
134Primitive neuroectodermal tumor (HP:0030065)1.60777091
135Neuroblastic tumors (HP:0004376)1.60777091
136Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.60777091
137Urethral obstruction (HP:0000796)1.59968452
138Breech presentation (HP:0001623)1.57755776
139Overriding aorta (HP:0002623)1.57020457
140Deep philtrum (HP:0002002)1.56285854
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55159000
142Absent epiphyses (HP:0010577)1.55159000
143Type I transferrin isoform profile (HP:0003642)1.53678346
144Megaloblastic anemia (HP:0001889)1.53658277
145Hyperinsulinemic hypoglycemia (HP:0000825)1.53503934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.87918709
2CDC73.85128216
3BUB13.41719848
4TSSK63.10783889
5PBK3.09965348
6CDK122.81847235
7BRSK22.77478088
8NEK22.54422750
9NEK12.50782434
10VRK22.48963708
11PASK2.36209969
12EIF2AK12.31205667
13EPHA22.29784638
14SMG12.26306179
15TTK2.25671297
16SCYL22.15150697
17SRPK12.13322565
18EEF2K1.95063570
19PLK31.90949560
20RPS6KB21.89566682
21PLK11.86461936
22TAF11.83634280
23ACVR1B1.78474772
24PKN21.71131839
25ATR1.68538345
26PLK41.66947650
27NME21.64297792
28EIF2AK31.61659785
29AURKB1.60110153
30ALK1.59501324
31MKNK11.57112446
32CDK71.54476241
33CDK41.46456091
34BRSK11.45621345
35CHEK11.45146353
36MAP3K81.42872950
37CHEK21.41156695
38TESK21.38822598
39NME11.38646337
40TGFBR11.35968213
41RPS6KA41.34677538
42MST1R1.34177011
43FLT31.28336294
44STK101.27539899
45ERBB41.24147439
46MKNK21.14182414
47VRK11.14010526
48LATS11.12198682
49EIF2AK21.08151934
50BRD41.05933359
51AKT31.05495791
52MAP3K101.03287706
53PAK41.00689928
54ATM1.00435668
55* CDK20.99174707
56TRIM280.97331656
57LATS20.96919260
58AURKA0.96565005
59DYRK30.95652873
60CDK60.93569107
61PDK30.93071417
62PDK40.93071417
63PNCK0.88245101
64TRIB30.86974735
65IRAK30.86951817
66MTOR0.86892760
67STK30.85015425
68PIM10.83204986
69ZAK0.82724554
70STK38L0.77626277
71ICK0.77532625
72LRRK20.75523091
73STK40.74261054
74CSNK2A20.74008466
75MELK0.71963466
76MAP2K30.71632929
77TLK10.70119367
78TTN0.68033160
79CDK10.67217002
80MET0.67011221
81CLK10.64886652
82MAP3K30.64825639
83CDK90.62431241
84PRKCI0.61356662
85TAOK20.59621779
86PAK20.59601001
87FGFR10.59421726
88CSNK1E0.58643252
89PAK10.57083182
90MAP3K90.56821458
91MAP4K10.53932539
92TESK10.52713394
93MARK30.51681407
94CSNK2A10.48860147
95PRKDC0.48718152
96AKT20.48463730
97MAPKAPK30.48257308
98NUAK10.47597102
99PDK20.47569099
100DAPK10.45515219
101STK160.44453411
102PDGFRA0.43618712
103MAP3K110.42884729
104TNIK0.41695336
105CDK80.39079787
106MAPKAPK50.37973714
107CAMK1G0.36844331
108CCNB10.36539886
109CSNK1D0.34279137
110GRK60.33695397
111MAPK140.33643100
112MAP3K50.33462224
113RPS6KB10.33184495
114TAOK10.32426531
115ZAP700.32186268
116CSNK1G10.32090558
117JAK30.31675096
118PTK20.30541035
119RAF10.29912967
120ARAF0.29539413
121NEK90.27832131
122CAMK1D0.27746731
123CDK180.26682004
124CDK11A0.26126098
125CSNK1A1L0.25586106
126RPS6KA50.24345393
127BRAF0.23580237
128BMX0.23177404
129MST40.22024436

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46149054
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.42000687
3Mismatch repair_Homo sapiens_hsa034304.03409021
4RNA transport_Homo sapiens_hsa030133.62217321
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.38615913
6One carbon pool by folate_Homo sapiens_hsa006703.25539558
7Spliceosome_Homo sapiens_hsa030403.23092227
8RNA polymerase_Homo sapiens_hsa030202.90936507
9Base excision repair_Homo sapiens_hsa034102.70669072
10Cell cycle_Homo sapiens_hsa041102.69396862
11Nucleotide excision repair_Homo sapiens_hsa034202.68125233
12Proteasome_Homo sapiens_hsa030502.55040923
13Homologous recombination_Homo sapiens_hsa034402.51480134
14Ribosome_Homo sapiens_hsa030102.29970653
15Pyrimidine metabolism_Homo sapiens_hsa002402.12480221
16mRNA surveillance pathway_Homo sapiens_hsa030152.04077162
17Fanconi anemia pathway_Homo sapiens_hsa034602.00376215
18RNA degradation_Homo sapiens_hsa030181.94192907
19Non-homologous end-joining_Homo sapiens_hsa034501.92835310
20Basal transcription factors_Homo sapiens_hsa030221.67036456
21p53 signaling pathway_Homo sapiens_hsa041151.65097429
22Pyruvate metabolism_Homo sapiens_hsa006201.43992575
23Selenocompound metabolism_Homo sapiens_hsa004501.38884748
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34861079
25Systemic lupus erythematosus_Homo sapiens_hsa053221.25235418
26Antigen processing and presentation_Homo sapiens_hsa046121.22428897
27Epstein-Barr virus infection_Homo sapiens_hsa051691.22294101
28Viral carcinogenesis_Homo sapiens_hsa052031.18130098
29Biosynthesis of amino acids_Homo sapiens_hsa012301.17371398
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14951088
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14631894
32Purine metabolism_Homo sapiens_hsa002301.08219288
33Oocyte meiosis_Homo sapiens_hsa041141.01321534
34Vitamin B6 metabolism_Homo sapiens_hsa007501.00698368
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.00132154
36Thyroid cancer_Homo sapiens_hsa052161.00074931
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98400895
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96517781
39Propanoate metabolism_Homo sapiens_hsa006400.95008946
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93644646
41Steroid biosynthesis_Homo sapiens_hsa001000.92128301
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.89540946
43Pentose phosphate pathway_Homo sapiens_hsa000300.88848000
44Herpes simplex infection_Homo sapiens_hsa051680.84410841
45MicroRNAs in cancer_Homo sapiens_hsa052060.83915547
46HTLV-I infection_Homo sapiens_hsa051660.81656908
47Small cell lung cancer_Homo sapiens_hsa052220.75000472
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.70427031
49mTOR signaling pathway_Homo sapiens_hsa041500.70355910
50Fatty acid elongation_Homo sapiens_hsa000620.67603582
51Legionellosis_Homo sapiens_hsa051340.67381955
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66997502
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66348404
54Carbon metabolism_Homo sapiens_hsa012000.63550271
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63543985
56Hippo signaling pathway_Homo sapiens_hsa043900.61686500
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61296507
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60680129
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58491576
60TGF-beta signaling pathway_Homo sapiens_hsa043500.57576340
61Folate biosynthesis_Homo sapiens_hsa007900.57510457
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.57297712
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54707814
64Arginine and proline metabolism_Homo sapiens_hsa003300.54309944
65Colorectal cancer_Homo sapiens_hsa052100.54270977
66Huntingtons disease_Homo sapiens_hsa050160.51694057
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51690635
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51066621
69Chronic myeloid leukemia_Homo sapiens_hsa052200.50417159
70Bladder cancer_Homo sapiens_hsa052190.49728481
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47787902
72Adherens junction_Homo sapiens_hsa045200.47557510
73Fructose and mannose metabolism_Homo sapiens_hsa000510.47455664
74N-Glycan biosynthesis_Homo sapiens_hsa005100.46050137
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45896071
76Apoptosis_Homo sapiens_hsa042100.45375044
77Alcoholism_Homo sapiens_hsa050340.44923176
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44816750
79HIF-1 signaling pathway_Homo sapiens_hsa040660.43451106
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42663370
81Fatty acid metabolism_Homo sapiens_hsa012120.41519683
82Galactose metabolism_Homo sapiens_hsa000520.40881060
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39292785
84Sulfur relay system_Homo sapiens_hsa041220.39147593
85Parkinsons disease_Homo sapiens_hsa050120.38656011
86Metabolic pathways_Homo sapiens_hsa011000.37562065
87Hepatitis B_Homo sapiens_hsa051610.36426855
88Wnt signaling pathway_Homo sapiens_hsa043100.33493241
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33140266
90Arginine biosynthesis_Homo sapiens_hsa002200.31948242
91Acute myeloid leukemia_Homo sapiens_hsa052210.31641051
92Lysine degradation_Homo sapiens_hsa003100.31139000
93Shigellosis_Homo sapiens_hsa051310.30587544
94Prostate cancer_Homo sapiens_hsa052150.28817893
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27481381
96Basal cell carcinoma_Homo sapiens_hsa052170.27249208
97Viral myocarditis_Homo sapiens_hsa054160.26939851
98Proteoglycans in cancer_Homo sapiens_hsa052050.25748638
99Pathways in cancer_Homo sapiens_hsa052000.24649298
100Protein export_Homo sapiens_hsa030600.23243588
101Non-small cell lung cancer_Homo sapiens_hsa052230.22215646
102Tight junction_Homo sapiens_hsa045300.22109050
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21963351
104Hedgehog signaling pathway_Homo sapiens_hsa043400.21941554
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20992105
106Measles_Homo sapiens_hsa051620.20713662
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20357480
108Influenza A_Homo sapiens_hsa051640.20194491
109Primary immunodeficiency_Homo sapiens_hsa053400.19625172
110Glutathione metabolism_Homo sapiens_hsa004800.18503547
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.18182558
112Type I diabetes mellitus_Homo sapiens_hsa049400.18162125
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18138879
114FoxO signaling pathway_Homo sapiens_hsa040680.17982716
115Endometrial cancer_Homo sapiens_hsa052130.17896134
116Notch signaling pathway_Homo sapiens_hsa043300.16882746
117Oxidative phosphorylation_Homo sapiens_hsa001900.15746879
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14727097
119Melanoma_Homo sapiens_hsa052180.14634324
120Fatty acid biosynthesis_Homo sapiens_hsa000610.14238058
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14084219
122Glucagon signaling pathway_Homo sapiens_hsa049220.13533836
123Renin-angiotensin system_Homo sapiens_hsa046140.13323423
124Pancreatic cancer_Homo sapiens_hsa052120.13144036
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12789812

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