TSR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.24277894
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.08424499
3proteasome assembly (GO:0043248)5.00826584
4ribosomal small subunit biogenesis (GO:0042274)4.65941952
5viral transcription (GO:0019083)4.51355651
6formation of translation preinitiation complex (GO:0001731)4.48894146
7maturation of SSU-rRNA (GO:0030490)4.44120706
8translational termination (GO:0006415)4.43245743
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.34307445
10ribosomal small subunit assembly (GO:0000028)4.30910140
11cullin deneddylation (GO:0010388)4.29566350
12spliceosomal snRNP assembly (GO:0000387)4.20741896
13ribosomal large subunit biogenesis (GO:0042273)4.19418825
14protein deneddylation (GO:0000338)4.17853486
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.16170008
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10846261
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.09280728
18translational initiation (GO:0006413)4.08188436
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.05624558
20ribonucleoprotein complex biogenesis (GO:0022613)4.03089011
21transcription elongation from RNA polymerase III promoter (GO:0006385)4.02343254
22termination of RNA polymerase III transcription (GO:0006386)4.02343254
23translational elongation (GO:0006414)4.01989134
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.01273485
25purine nucleobase biosynthetic process (GO:0009113)3.98207582
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97775589
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96678972
28negative regulation of ligase activity (GO:0051352)3.96678972
29cotranslational protein targeting to membrane (GO:0006613)3.93842017
30protein targeting to ER (GO:0045047)3.88410132
31nucleobase biosynthetic process (GO:0046112)3.88109113
32ribosome biogenesis (GO:0042254)3.82784356
33DNA strand elongation involved in DNA replication (GO:0006271)3.82597668
34protein retention in ER lumen (GO:0006621)3.80042054
35GDP-mannose metabolic process (GO:0019673)3.79154003
36translation (GO:0006412)3.79105862
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78768340
38protein localization to endoplasmic reticulum (GO:0070972)3.75000891
39regulation of mitochondrial translation (GO:0070129)3.74898146
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.70544908
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.70456684
42ATP synthesis coupled proton transport (GO:0015986)3.70456684
43DNA replication checkpoint (GO:0000076)3.69259662
44viral mRNA export from host cell nucleus (GO:0046784)3.68376083
45positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.66268715
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66118878
47cellular protein complex disassembly (GO:0043624)3.65860610
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.65353543
49DNA strand elongation (GO:0022616)3.62972516
50spliceosomal complex assembly (GO:0000245)3.62204666
51* rRNA processing (GO:0006364)3.60037291
52protein insertion into membrane (GO:0051205)3.59861108
53protein targeting to membrane (GO:0006612)3.57752109
54telomere maintenance via semi-conservative replication (GO:0032201)3.57547223
55protein maturation by protein folding (GO:0022417)3.55613633
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54464748
577-methylguanosine mRNA capping (GO:0006370)3.54250780
58iron-sulfur cluster assembly (GO:0016226)3.53802615
59metallo-sulfur cluster assembly (GO:0031163)3.53802615
60viral life cycle (GO:0019058)3.53239521
61establishment of protein localization to mitochondrion (GO:0072655)3.52549361
62UV protection (GO:0009650)3.52054063
63positive regulation of ligase activity (GO:0051351)3.52010982
64DNA replication initiation (GO:0006270)3.51608575
65guanosine-containing compound biosynthetic process (GO:1901070)3.49602473
66ribosome assembly (GO:0042255)3.48698258
67cellular component biogenesis (GO:0044085)3.47469550
68rRNA modification (GO:0000154)3.47057955
69* rRNA metabolic process (GO:0016072)3.45975853
70regulation of cellular amino acid metabolic process (GO:0006521)3.45472431
71RNA capping (GO:0036260)3.44235169
727-methylguanosine RNA capping (GO:0009452)3.44235169
73negative regulation of cell size (GO:0045792)3.43903384
74protein targeting to mitochondrion (GO:0006626)3.43354499
75mitotic metaphase plate congression (GO:0007080)3.42303222
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40864802
77apoptotic process involved in morphogenesis (GO:0060561)3.39894056
78pentose metabolic process (GO:0019321)3.36948191
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34815882
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34815882
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34815882
82mitochondrion transport along microtubule (GO:0047497)3.34694937
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.34694937
84peptidyl-arginine omega-N-methylation (GO:0035247)3.34648423
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34028035
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34028035
87signal transduction involved in DNA damage checkpoint (GO:0072422)3.34003734
88signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34003734
89chaperone-mediated protein transport (GO:0072321)3.33142602
90establishment of mitochondrion localization (GO:0051654)3.31474444
91signal transduction involved in cell cycle checkpoint (GO:0072395)3.31139689
92termination of RNA polymerase I transcription (GO:0006363)3.29805770
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.29621558
94protein complex disassembly (GO:0043241)3.29304593
95transcription elongation from RNA polymerase I promoter (GO:0006362)3.28338959
96histone arginine methylation (GO:0034969)3.27296974
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26005239
98tooth mineralization (GO:0034505)3.23601387
99transcription-coupled nucleotide-excision repair (GO:0006283)3.23142751
100GTP biosynthetic process (GO:0006183)3.22960087
101UTP biosynthetic process (GO:0006228)3.22485291
102regulation of mammary gland epithelial cell proliferation (GO:0033599)3.21867099
103UTP metabolic process (GO:0046051)3.21402252
104pseudouridine synthesis (GO:0001522)3.21030110
105macromolecular complex disassembly (GO:0032984)3.18437425
106regulation of ligase activity (GO:0051340)3.15815552
107protein localization to mitochondrion (GO:0070585)3.14505670
108response to misfolded protein (GO:0051788)3.13093795
109pyrimidine nucleotide catabolic process (GO:0006244)3.12893786
110transcription from RNA polymerase I promoter (GO:0006360)3.09848871
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08418718
112regulation of early endosome to late endosome transport (GO:2000641)3.07645492
113nucleobase-containing small molecule interconversion (GO:0015949)3.06927281
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04537582
115nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03126200
116telomere maintenance via recombination (GO:0000722)3.02187537
117regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.02149262
118establishment of integrated proviral latency (GO:0075713)3.00304435
119cell cycle G1/S phase transition (GO:0044843)2.99651443
120G1/S transition of mitotic cell cycle (GO:0000082)2.99651443
121ncRNA 3-end processing (GO:0043628)2.97300273
122folic acid-containing compound biosynthetic process (GO:0009396)2.97030772
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96981490
124negative regulation of chromosome segregation (GO:0051985)2.96890869
125DNA-templated transcription, termination (GO:0006353)2.96521058
126lens fiber cell development (GO:0070307)2.96244551
127de novo protein folding (GO:0006458)2.95941688
128negative regulation of DNA-templated transcription, elongation (GO:0032785)2.93323639
129protein localization to endosome (GO:0036010)2.91445188
130pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.91083213
131proline biosynthetic process (GO:0006561)2.90534056
132establishment of protein localization to membrane (GO:0090150)2.87431654
133respiratory electron transport chain (GO:0022904)2.84665043
134CTP metabolic process (GO:0046036)2.82470219
135CTP biosynthetic process (GO:0006241)2.82470219
136pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.81776820
137negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.80142938
138pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77890575
139mitochondrial calcium ion transport (GO:0006851)2.77740136
140electron transport chain (GO:0022900)2.77646765
141mitotic nuclear envelope reassembly (GO:0007084)2.73356695
142nuclear envelope reassembly (GO:0031468)2.73356695
143pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.70235919
144activation of MAPKKK activity (GO:0000185)2.69651939
145deoxyribonucleotide catabolic process (GO:0009264)2.69253714
146mitochondrial fusion (GO:0008053)2.69012088
147viral protein processing (GO:0019082)2.68681595
148pentose-phosphate shunt (GO:0006098)2.67109075
149positive regulation of mitochondrion organization (GO:0010822)2.66169945
150barbed-end actin filament capping (GO:0051016)2.65552620
151regulation of protein heterodimerization activity (GO:0043497)2.65078435
152prostanoid biosynthetic process (GO:0046457)2.62822971
153prostaglandin biosynthetic process (GO:0001516)2.62822971
154pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62476727
155T cell apoptotic process (GO:0070231)2.62473985
156regulation of glucocorticoid metabolic process (GO:0031943)2.61937378
157regulation of apoptotic process involved in morphogenesis (GO:1902337)2.59393825
158regulation of chromatin binding (GO:0035561)2.57033457
159CDP-diacylglycerol metabolic process (GO:0046341)2.56827847
160post-embryonic morphogenesis (GO:0009886)2.55873112
161cell migration in hindbrain (GO:0021535)2.54536423
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.53443198
163nuclear-transcribed mRNA catabolic process (GO:0000956)2.53180502
164purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52557378
165modulation by virus of host process (GO:0019054)2.52189472
166protein targeting (GO:0006605)2.51276897
167misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.50443290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.52295455
2E2F7_22180533_ChIP-Seq_HELA_Human4.46666994
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13926218
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07639754
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.91833934
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.88256060
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.70299220
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.64948677
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.39266152
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.25252518
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17155729
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15263655
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15142655
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99441801
15VDR_21846776_ChIP-Seq_THP-1_Human2.89603498
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.86646315
17LXR_22292898_ChIP-Seq_THP-1_Human2.82452170
18XRN2_22483619_ChIP-Seq_HELA_Human2.72616082
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.57215625
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55618151
21VDR_23849224_ChIP-Seq_CD4+_Human2.54448154
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52720120
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51543235
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50400795
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.41916578
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40391759
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36243868
28DCP1A_22483619_ChIP-Seq_HELA_Human2.34228287
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33529320
30GABP_19822575_ChIP-Seq_HepG2_Human2.30765413
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28903387
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.27644053
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.20095414
34TTF2_22483619_ChIP-Seq_HELA_Human2.19707666
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18873143
36TET1_21451524_ChIP-Seq_MESCs_Mouse2.16503204
37FOXP3_21729870_ChIP-Seq_TREG_Human2.12338598
38ELK3_25401928_ChIP-Seq_HUVEC_Human2.11278121
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09826935
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.01280591
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00877075
42ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00252571
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92033412
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90484955
45RACK7_27058665_Chip-Seq_MCF-7_Human1.89901500
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88690001
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.86972639
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84789412
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83870683
50P68_20966046_ChIP-Seq_HELA_Human1.83089930
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80201762
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.78074937
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72174353
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71516582
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69561900
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69014587
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68787656
58ZNF263_19887448_ChIP-Seq_K562_Human1.67660004
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.67491435
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67260094
61KDM2B_26808549_Chip-Seq_DND41_Human1.64518404
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62673347
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62068839
64KDM2B_26808549_Chip-Seq_K562_Human1.57561062
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57060590
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55207218
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54269012
68CIITA_25753668_ChIP-Seq_RAJI_Human1.53741807
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52896625
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.52592643
71ELK1_19687146_ChIP-ChIP_HELA_Human1.51760603
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51432822
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48640458
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47964141
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47602795
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46947498
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45474789
78KDM5A_27292631_Chip-Seq_BREAST_Human1.44982197
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43627286
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43609126
81CTCF_27219007_Chip-Seq_Bcells_Human1.41434249
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38677089
83SMC4_20622854_ChIP-Seq_HELA_Human1.38536739
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38225840
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37526664
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.37386881
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36623211
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35914636
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35837953
90BCL6_27268052_Chip-Seq_Bcells_Human1.35253265
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34136733
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33225492
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32601740
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32228510
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31681756
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30717615
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.29242545
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27162143
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.27052834
100TP53_22127205_ChIP-Seq_IMR90_Human1.22208559
101AR_21909140_ChIP-Seq_LNCAP_Human1.21993634
102BCOR_27268052_Chip-Seq_Bcells_Human1.21803539
103CREB1_26743006_Chip-Seq_LNCaP_Human1.21715949
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20475222
105SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20247077
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19474660
107ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18269513
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18095327
109MAF_26560356_Chip-Seq_TH2_Human1.17133937
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16549928
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16187699
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.13987153
113SA1_27219007_Chip-Seq_Bcells_Human1.13717403
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13524060
115TCF7_22412390_ChIP-Seq_EML_Mouse1.12919201
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12167159
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11902404
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11418869
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10949102
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10393108
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10162598
122PHF8_20622854_ChIP-Seq_HELA_Human1.09158290
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07835496
124VDR_24763502_ChIP-Seq_THP-1_Human1.07815200
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07107884
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06839002
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.06441121
128CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05965866
129SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05398291
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05168416
131PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04859149
132E2F1_20622854_ChIP-Seq_HELA_Human1.04806403
133CTCF_21964334_Chip-Seq_Bcells_Human1.04517807
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04512115
135MYC_18940864_ChIP-ChIP_HL60_Human1.03532641
136OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03498104
137PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03439339
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02266584
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02253657
140ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02238557
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02223731
142CTCF_20526341_ChIP-Seq_ESCs_Human1.01470687
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00780804
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.99978498
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99531701
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99253561
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98809662
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.98778365
149TFEB_21752829_ChIP-Seq_HELA_Human0.98428589
150CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98092862
151SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97417599
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.97210747
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96714741
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95973872
155FOXP1_21924763_ChIP-Seq_HESCs_Human0.94009995
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92766402
157MYC_22102868_ChIP-Seq_BL_Human0.90510728
158SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90410565
159GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89922636
160CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88666712
161SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88223040
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88033197
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87896416
164NOTCH1_21737748_ChIP-Seq_TLL_Human0.87603923
165TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87565369
166CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85752292
167CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83860192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.08829708
2MP0004957_abnormal_blastocyst_morpholog4.77007444
3MP0003111_abnormal_nucleus_morphology4.15024491
4MP0003077_abnormal_cell_cycle3.71935428
5MP0010094_abnormal_chromosome_stability3.55445818
6MP0005058_abnormal_lysosome_morphology3.48178887
7MP0005451_abnormal_body_composition3.36147034
8MP0009278_abnormal_bone_marrow3.27222464
9MP0008932_abnormal_embryonic_tissue3.11210142
10MP0003123_paternal_imprinting3.00437606
11MP0009840_abnormal_foam_cell2.96418492
12MP0008058_abnormal_DNA_repair2.91462742
13MP0004858_abnormal_nervous_system2.82974614
14MP0003718_maternal_effect2.78586648
15MP0008057_abnormal_DNA_replication2.75302823
16MP0003705_abnormal_hypodermis_morpholog2.53331426
17MP0008007_abnormal_cellular_replicative2.41551966
18MP0006292_abnormal_olfactory_placode2.38480885
19MP0004185_abnormal_adipocyte_glucose2.36251204
20MP0008877_abnormal_DNA_methylation2.35589538
21MP0005623_abnormal_meninges_morphology2.34326049
22MP0003786_premature_aging2.32619096
23MP0000003_abnormal_adipose_tissue2.32411060
24MP0009379_abnormal_foot_pigmentation2.29383489
25MP0003329_amyloid_beta_deposits2.20643051
26MP0001730_embryonic_growth_arrest2.12062461
27MP0004133_heterotaxia2.11078012
28MP0006035_abnormal_mitochondrial_morpho2.10480786
29MP0001529_abnormal_vocalization2.06906276
30MP0010030_abnormal_orbit_morphology2.04174317
31MP0001348_abnormal_lacrimal_gland2.03798202
32MP0000678_abnormal_parathyroid_gland2.02206108
33MP0005375_adipose_tissue_phenotype1.99679052
34MP0002877_abnormal_melanocyte_morpholog1.99432570
35MP0002249_abnormal_larynx_morphology1.88338622
36MP0004859_abnormal_synaptic_plasticity1.84033980
37MP0003806_abnormal_nucleotide_metabolis1.83740870
38MP0003122_maternal_imprinting1.82570586
39MP0003121_genomic_imprinting1.80338936
40MP0002653_abnormal_ependyma_morphology1.79788315
41MP0000013_abnormal_adipose_tissue1.79493682
42MP0000350_abnormal_cell_proliferation1.77504937
43MP0000358_abnormal_cell_content/1.75603532
44MP0001849_ear_inflammation1.71810242
45MP0005666_abnormal_adipose_tissue1.71421936
46MP0004510_myositis1.69441040
47MP0005257_abnormal_intraocular_pressure1.68765158
48MP0006036_abnormal_mitochondrial_physio1.68564337
49MP0006276_abnormal_autonomic_nervous1.66489801
50MP0005501_abnormal_skin_physiology1.65902845
51MP0002638_abnormal_pupillary_reflex1.60659909
52MP0003315_abnormal_perineum_morphology1.58762884
53MP0002751_abnormal_autonomic_nervous1.56758259
54MP0001697_abnormal_embryo_size1.55966885
55MP0008438_abnormal_cutaneous_collagen1.54702882
56MP0002080_prenatal_lethality1.53198646
57MP0003119_abnormal_digestive_system1.50141984
58MP0001905_abnormal_dopamine_level1.47324488
59MP0000759_abnormal_skeletal_muscle1.46830425
60MP0000681_abnormal_thyroid_gland1.45672553
61MP0003183_abnormal_peptide_metabolism1.40766748
62MP0002085_abnormal_embryonic_tissue1.39716349
63MP0006072_abnormal_retinal_apoptosis1.36701625
64MP0003890_abnormal_embryonic-extraembry1.34877935
65MP0003279_aneurysm1.32490966
66MP0009384_cardiac_valve_regurgitation1.32389838
67MP0001672_abnormal_embryogenesis/_devel1.31125558
68MP0005380_embryogenesis_phenotype1.31125558
69MP0000313_abnormal_cell_death1.30548682
70MP0002796_impaired_skin_barrier1.24943132
71MP0001542_abnormal_bone_strength1.22900183
72MP0002822_catalepsy1.22827619
73MP0005670_abnormal_white_adipose1.22456778
74MP0000747_muscle_weakness1.19439386
75MP0000733_abnormal_muscle_development1.19232949
76MP0002396_abnormal_hematopoietic_system1.16958470
77MP0003453_abnormal_keratinocyte_physiol1.16574033
78MP0002084_abnormal_developmental_patter1.15556262
79MP0000751_myopathy1.14881725
80MP0000343_altered_response_to1.14860230
81MP0000566_synostosis1.14065671
82MP0002160_abnormal_reproductive_system1.13368778
83MP0005503_abnormal_tendon_morphology1.11783794
84MP0003303_peritoneal_inflammation1.11296848
85MP0001727_abnormal_embryo_implantation1.09940535
86MP0003984_embryonic_growth_retardation1.09855185
87MP0002163_abnormal_gland_morphology1.09689736
88MP0002088_abnormal_embryonic_growth/wei1.07761282
89MP0004233_abnormal_muscle_weight1.04713357
90MP0005394_taste/olfaction_phenotype1.03858813
91MP0005499_abnormal_olfactory_system1.03858813
92MP0005508_abnormal_skeleton_morphology1.03818891
93MP0004130_abnormal_muscle_cell1.02998217
94MP0005397_hematopoietic_system_phenotyp1.02233940
95MP0001545_abnormal_hematopoietic_system1.02233940
96MP0001145_abnormal_male_reproductive1.01855267
97MP0002210_abnormal_sex_determination0.99461793
98MP0008260_abnormal_autophagy0.99416376
99MP0005266_abnormal_metabolism0.99313104
100MP0009333_abnormal_splenocyte_physiolog0.98898962
101MP0004142_abnormal_muscle_tone0.98224723
102MP0003879_abnormal_hair_cell0.97584546
103MP0004087_abnormal_muscle_fiber0.95874735
104MP0005389_reproductive_system_phenotype0.94644684
105MP0000858_altered_metastatic_potential0.93248129
106MP0002089_abnormal_postnatal_growth/wei0.91803337
107MP0002971_abnormal_brown_adipose0.91256973
108MP0003172_abnormal_lysosome_physiology0.91218618
109MP0002909_abnormal_adrenal_gland0.90855218
110MP0000537_abnormal_urethra_morphology0.90803570
111MP0002019_abnormal_tumor_incidence0.90670588
112MP0003191_abnormal_cellular_cholesterol0.89196005
113MP0000762_abnormal_tongue_morphology0.89154174
114MP0003634_abnormal_glial_cell0.86457324
115MP0000490_abnormal_crypts_of0.86291938
116MP0002938_white_spotting0.85243362
117MP0001919_abnormal_reproductive_system0.84869653
118MP0000604_amyloidosis0.83085734
119MP0005381_digestive/alimentary_phenotyp0.82104553
120MP0005384_cellular_phenotype0.81751655
121MP0002736_abnormal_nociception_after0.79911099
122MP0000749_muscle_degeneration0.79308176
123MP0002269_muscular_atrophy0.79059727
124MP0000049_abnormal_middle_ear0.78660797
125MP0001293_anophthalmia0.77657286
126MP0000653_abnormal_sex_gland0.76925674
127MP0000750_abnormal_muscle_regeneration0.76903137
128MP0005330_cardiomyopathy0.76720972
129MP0001502_abnormal_circadian_rhythm0.76228122
130MP0002111_abnormal_tail_morphology0.75601710
131MP0004145_abnormal_muscle_electrophysio0.75545924
132MP0001663_abnormal_digestive_system0.75364815
133MP0003861_abnormal_nervous_system0.74799734
134MP0008874_decreased_physiological_sensi0.74727098
135MP0005076_abnormal_cell_differentiation0.74720663
136MP0009672_abnormal_birth_weight0.73516205
137MP0003436_decreased_susceptibility_to0.73289975
138MP0001929_abnormal_gametogenesis0.73275426
139MP0000703_abnormal_thymus_morphology0.72193719
140MP0005390_skeleton_phenotype0.72047867
141MP0002086_abnormal_extraembryonic_tissu0.72029186
142MP0001873_stomach_inflammation0.71390310
143MP0002102_abnormal_ear_morphology0.69652610
144MP0005193_abnormal_anterior_eye0.69175467
145MP0003221_abnormal_cardiomyocyte_apopto0.69037930
146MP0010386_abnormal_urinary_bladder0.67153431
147MP0003567_abnormal_fetal_cardiomyocyte0.67122241
148MP0000955_abnormal_spinal_cord0.65253375
149MP0003283_abnormal_digestive_organ0.64696182
150MP0004197_abnormal_fetal_growth/weight/0.64611406
151MP0002184_abnormal_innervation0.64140813
152MP0004272_abnormal_basement_membrane0.63784422
153MP0002114_abnormal_axial_skeleton0.63150313
154MP0002234_abnormal_pharynx_morphology0.62399576
155MP0001188_hyperpigmentation0.62156888
156MP0003186_abnormal_redox_activity0.62132427
157MP0003385_abnormal_body_wall0.61033287
158MP0009250_abnormal_appendicular_skeleto0.60506887
159MP0002733_abnormal_thermal_nociception0.60306872
160MP0005395_other_phenotype0.60236860
161MP0002970_abnormal_white_adipose0.59561220
162MP0008789_abnormal_olfactory_epithelium0.58607581
163MP0001764_abnormal_homeostasis0.57259004
164MP0000015_abnormal_ear_pigmentation0.56860643
165MP0002169_no_abnormal_phenotype0.55887386
166MP0003942_abnormal_urinary_system0.55719804
167MP0002873_normal_phenotype0.54539996
168MP0009053_abnormal_anal_canal0.53437537
169MP0005379_endocrine/exocrine_gland_phen0.53172011
170MP0008995_early_reproductive_senescence0.52992650
171MP0005621_abnormal_cell_physiology0.51489358
172MP0002127_abnormal_cardiovascular_syste0.50948287
173MP0005376_homeostasis/metabolism_phenot0.50656794
174MP0002932_abnormal_joint_morphology0.50126813
175MP0008770_decreased_survivor_rate0.49888084
176MP0002161_abnormal_fertility/fecundity0.49319984

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.39839601
2Birth length less than 3rd percentile (HP:0003561)4.26187138
3Achilles tendon contracture (HP:0001771)4.06691812
4Abnormal number of erythroid precursors (HP:0012131)4.03936505
5Cerebral hypomyelination (HP:0006808)3.82569062
6Breast hypoplasia (HP:0003187)3.73967662
7Acute necrotizing encephalopathy (HP:0006965)3.72666935
8Reticulocytopenia (HP:0001896)3.69028803
9Mitochondrial inheritance (HP:0001427)3.63686036
10Hepatocellular necrosis (HP:0001404)3.61822171
11Abnormality of the Achilles tendon (HP:0005109)3.48280238
12Abnormal mitochondria in muscle tissue (HP:0008316)3.48247621
13Patellar aplasia (HP:0006443)3.45110975
14Rough bone trabeculation (HP:0100670)3.43236614
15Increased CSF lactate (HP:0002490)3.33574037
16Oral leukoplakia (HP:0002745)3.32934345
17Aplasia/Hypoplasia of the patella (HP:0006498)3.31372149
18Hyperacusis (HP:0010780)3.30390968
19Microretrognathia (HP:0000308)3.27018939
20Increased muscle lipid content (HP:0009058)3.25728505
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.25358080
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.25358080
23Carpal bone hypoplasia (HP:0001498)3.25335213
24Macrocytic anemia (HP:0001972)3.24949034
25Increased serum lactate (HP:0002151)3.16361395
26Secondary amenorrhea (HP:0000869)3.09006094
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07182745
283-Methylglutaconic aciduria (HP:0003535)3.06530359
29Degeneration of anterior horn cells (HP:0002398)3.05330662
30Abnormality of the anterior horn cell (HP:0006802)3.05330662
31Hyperthyroidism (HP:0000836)3.02576691
32Protrusio acetabuli (HP:0003179)2.99787909
33Emotional lability (HP:0000712)2.99221028
34Myopathic facies (HP:0002058)2.98279532
35Acute encephalopathy (HP:0006846)2.94140060
36Abnormality of glycolysis (HP:0004366)2.93517666
37Increased serum pyruvate (HP:0003542)2.93517666
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93200567
39Hepatic necrosis (HP:0002605)2.90470793
40Broad distal phalanx of finger (HP:0009836)2.90053060
41Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89712989
42Vertebral compression fractures (HP:0002953)2.88484881
43Aplastic anemia (HP:0001915)2.83481912
44Increased hepatocellular lipid droplets (HP:0006565)2.77650767
45Insomnia (HP:0100785)2.75033526
46Progressive macrocephaly (HP:0004481)2.73074733
47Type 1 muscle fiber predominance (HP:0003803)2.67186824
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.65993075
49Distal lower limb muscle weakness (HP:0009053)2.64210074
50Premature rupture of membranes (HP:0001788)2.64157862
51Abnormality of the labia minora (HP:0012880)2.63606044
52Progressive muscle weakness (HP:0003323)2.63081397
53Premature graying of hair (HP:0002216)2.60152837
54Pallor (HP:0000980)2.59505595
55Unsteady gait (HP:0002317)2.59229313
56Delusions (HP:0000746)2.58566199
57CNS demyelination (HP:0007305)2.57485154
58CNS hypomyelination (HP:0003429)2.54935836
59Microvesicular hepatic steatosis (HP:0001414)2.54217359
60Lactic acidosis (HP:0003128)2.52552741
61Selective tooth agenesis (HP:0001592)2.52444315
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40039782
63Shoulder girdle muscle weakness (HP:0003547)2.39298393
64Lipid accumulation in hepatocytes (HP:0006561)2.38474520
65Premature ovarian failure (HP:0008209)2.37884460
66Increased connective tissue (HP:0009025)2.37504251
67Progressive external ophthalmoplegia (HP:0000590)2.37005708
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34645040
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.32200227
70Poor suck (HP:0002033)2.32037647
71Hyperparathyroidism (HP:0000843)2.31491712
72Overriding aorta (HP:0002623)2.31333885
73Multiple enchondromatosis (HP:0005701)2.31185723
74Hypertensive crisis (HP:0100735)2.30481226
75Exercise intolerance (HP:0003546)2.30458892
76Abnormal trabecular bone morphology (HP:0100671)2.29682875
77Cellular immunodeficiency (HP:0005374)2.29624871
78Abnormality of dentin (HP:0010299)2.29463650
79Myokymia (HP:0002411)2.29452110
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.28447966
81Upper limb amyotrophy (HP:0009129)2.28111769
82Distal upper limb amyotrophy (HP:0007149)2.28111769
83Increased variability in muscle fiber diameter (HP:0003557)2.26242195
84Hypoplasia of the pons (HP:0012110)2.25892079
85Truncus arteriosus (HP:0001660)2.25743800
86Prolonged neonatal jaundice (HP:0006579)2.25546764
87Abnormality of skeletal muscle fiber size (HP:0012084)2.24182606
88Trismus (HP:0000211)2.23693354
89Cleft eyelid (HP:0000625)2.23454768
90Exertional dyspnea (HP:0002875)2.22957574
91Colon cancer (HP:0003003)2.20821123
92Bulbar palsy (HP:0001283)2.19317911
93Spinal rigidity (HP:0003306)2.18207959
94Ankle clonus (HP:0011448)2.17351161
95Absent thumb (HP:0009777)2.16134146
96Turricephaly (HP:0000262)2.15682982
97Hypercalcemia (HP:0003072)2.13971217
98Respiratory failure (HP:0002878)2.10667167
99Absent radius (HP:0003974)2.09892281
100Genu recurvatum (HP:0002816)2.09835420
101Horseshoe kidney (HP:0000085)2.09302596
102Abnormality of liposaccharide metabolism (HP:0010968)2.09028907
103Abnormality of glycosphingolipid metabolism (HP:0004343)2.09028907
104Abnormality of glycolipid metabolism (HP:0010969)2.09028907
105Elbow flexion contracture (HP:0002987)2.08791045
106Rhabdomyolysis (HP:0003201)2.08277622
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07157400
108Abnormality of alanine metabolism (HP:0010916)2.07157400
109Hyperalaninemia (HP:0003348)2.07157400
110Short nail (HP:0001799)2.03973665
111Aplasia involving forearm bones (HP:0009822)2.03553919
112Absent forearm bone (HP:0003953)2.03553919
113Axonal loss (HP:0003447)2.03275600
114Fragile skin (HP:0001030)2.02298323
115Increased intramyocellular lipid droplets (HP:0012240)2.02211151
116Facial cleft (HP:0002006)2.01475667
117Mitral regurgitation (HP:0001653)2.01374653
118Elfin facies (HP:0004428)2.01269360
11911 pairs of ribs (HP:0000878)2.00978755
120Postnatal microcephaly (HP:0005484)2.00784560
121Exercise-induced myalgia (HP:0003738)2.00489674
122Distal lower limb amyotrophy (HP:0008944)2.00318264
123Long palpebral fissure (HP:0000637)1.99370961
124Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99319522
125Athetosis (HP:0002305)1.98310246
126Neoplasm of the pancreas (HP:0002894)1.96866224
127Round ear (HP:0100830)1.96535172
128Abnormality of reticulocytes (HP:0004312)1.95601972
129Ulnar bowing (HP:0003031)1.95410158
130Patellar dislocation (HP:0002999)1.94943751
131Cerebral edema (HP:0002181)1.94934134
132Growth hormone excess (HP:0000845)1.93854515
133Calcaneovalgus deformity (HP:0001848)1.93238032
134Atelectasis (HP:0100750)1.92637408
135Adducted thumb (HP:0001181)1.92564913
136Dysautonomia (HP:0002459)1.92425648
137Abnormal number of incisors (HP:0011064)1.91093104
138Stridor (HP:0010307)1.90728618
139Bladder diverticulum (HP:0000015)1.89404724
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89308716
141Absent epiphyses (HP:0010577)1.89308716
142Type I transferrin isoform profile (HP:0003642)1.88305834
143Cerebral inclusion bodies (HP:0100314)1.87443717
144Abnormality of the tricuspid valve (HP:0001702)1.86109867
145Renal Fanconi syndrome (HP:0001994)1.85636476
146Down-sloping shoulders (HP:0200021)1.85634524
147Self-mutilation (HP:0000742)1.84785622
148Renal duplication (HP:0000075)1.84313669
149Rectal prolapse (HP:0002035)1.83793655
150Congenital glaucoma (HP:0001087)1.83463735
151Muscle stiffness (HP:0003552)1.83448071
152Abnormality of the pons (HP:0007361)1.83144304
153Pelvic girdle muscle weakness (HP:0003749)1.82398025
154Irregular epiphyses (HP:0010582)1.82276718
155Hypokinesia (HP:0002375)1.81971926
156Supernumerary spleens (HP:0009799)1.81780911
157Female pseudohermaphroditism (HP:0010458)1.81169319
158Facial hemangioma (HP:0000329)1.80091584
159Muscle fiber inclusion bodies (HP:0100299)1.79033006
160Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78895443
161Hand muscle atrophy (HP:0009130)1.78786504
162Ragged-red muscle fibers (HP:0003200)1.78332308
163Failure to thrive in infancy (HP:0001531)1.76483696
164Sparse eyelashes (HP:0000653)1.75235525
165Aplasia/hypoplasia of the uterus (HP:0008684)1.74770582
166Congenital malformation of the right heart (HP:0011723)1.73426955
167Double outlet right ventricle (HP:0001719)1.73426955
168Abnormality of the ileum (HP:0001549)1.72765457
169Joint stiffness (HP:0001387)1.72317403
170Nemaline bodies (HP:0003798)1.71741685
171Hypercortisolism (HP:0001578)1.71169416
172Personality changes (HP:0000751)1.71045155
173Severe visual impairment (HP:0001141)1.70806982
174Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70361439
175Hydroureter (HP:0000072)1.70289787
176Difficulty climbing stairs (HP:0003551)1.68702456
177Premature skin wrinkling (HP:0100678)1.68418410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.31200018
2STK164.62649844
3WEE13.86685286
4TRIB33.69330955
5SRPK13.08787673
6SMG13.06339646
7EIF2AK12.84022361
8NME12.78836662
9IRAK32.74548396
10CDC72.72563082
11VRK22.60346862
12NME22.52392858
13TSSK62.44634832
14ERN12.42502397
15BRAF2.32833212
16SIK12.31798041
17TESK22.19501645
18PRPF4B2.07094347
19DYRK31.83822535
20TLK11.82440535
21PLK11.78368947
22PRKD31.75982518
23EPHB21.72240833
24BRSK21.71136053
25AURKA1.69030732
26NEK11.68797060
27TTN1.68663416
28ARAF1.68512989
29VRK11.63758501
30TTK1.60555622
31ICK1.60364953
32PLK41.57262661
33PNCK1.55020447
34MAP3K111.52741933
35NEK21.48354099
36PLK31.47708977
37SIK21.43953606
38EIF2AK31.42554489
39MAP3K121.41370990
40NTRK11.40873050
41MOS1.40786182
42CDK71.36950259
43CHEK21.36653441
44ACVR1B1.32607233
45PIM21.30167190
46BRSK11.24516595
47BCKDK1.23564495
48PASK1.22252776
49AURKB1.22230003
50DYRK21.20626842
51PRKD21.19035835
52EPHA21.15194956
53IRAK41.12838100
54MARK21.11574204
55KDR1.10638132
56RPS6KB21.08036450
57TYRO31.04831388
58LATS21.02678288
59TAOK11.02235191
60CCNB11.00395737
61ATR0.98924541
62DYRK1B0.94150518
63MAP4K10.92429173
64LIMK10.90425225
65DAPK10.89127099
66PKN20.88083916
67RPS6KA20.87416069
68DMPK0.87372892
69RPS6KC10.85538343
70RPS6KL10.85538343
71TESK10.85176722
72MAP2K30.84616145
73MAP3K10.84025718
74MAP3K80.82457933
75MAP3K100.82395358
76EEF2K0.82257066
77RPS6KA40.81441901
78MAP3K130.80732561
79PDPK10.79346401
80MAPKAPK30.77636245
81TBK10.77240847
82MARK10.76933393
83ZAK0.75193437
84CDK190.75151449
85CSNK2A20.74674694
86CDK80.74315443
87CSNK2A10.73811818
88PRKCI0.72997035
89SCYL20.72885997
90CHEK10.72762384
91IRAK20.69377283
92PAK10.68940725
93PAK60.67548371
94CSNK1G30.66925867
95ILK0.65718587
96PTK20.65283422
97RPS6KA60.64527436
98CAMKK10.64343729
99PHKG20.64267472
100PHKG10.64267472
101FLT30.62556385
102PAK40.61308851
103PRKG20.60397268
104MTOR0.58928192
105MINK10.58311150
106CDK20.56808219
107MKNK10.56041266
108HIPK20.55103566
109DAPK30.54639731
110MAPK110.54449953
111MAPK40.54283106
112GRK60.53398357
113GRK50.52451958
114TAOK20.52253955
115RIPK10.52142573
116CAMK2G0.51289509
117CDK140.51129725
118PTK60.51113537
119CSNK1E0.50731076
120CDK11A0.50647517
121MAPK120.49006725
122PDGFRA0.48770900
123CAMKK20.48743000
124RAF10.47956506
125CDK180.47421241
126UHMK10.46168022
127CDK150.45838135
128MKNK20.45813436
129MAP2K20.45462655
130RPS6KA50.45219519
131CDK10.45106164
132MAP2K40.43070567
133MAP3K90.42962306
134ABL20.41445172
135ATM0.41444581
136MUSK0.41191216
137STK38L0.39430845
138CDK40.39348364
139IRAK10.38562100
140CSNK1G10.37993090
141PAK20.37617627
142PDK20.36403323
143MAP3K40.35435095
144MAP2K70.35408071
145RPS6KA10.33977876
146ZAP700.33835565
147DDR20.32231064
148AKT20.31937496
149CAMK2B0.31789832
150CSNK1G20.28060114
151WNK30.27519329
152KSR10.25931712
153PRKCG0.24985641
154YES10.23666289
155MAPK90.22900469
156LRRK20.22071398

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.70549970
2Proteasome_Homo sapiens_hsa030504.66922481
3RNA polymerase_Homo sapiens_hsa030204.02792439
4DNA replication_Homo sapiens_hsa030303.81330312
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42328396
6Spliceosome_Homo sapiens_hsa030403.41158208
7Mismatch repair_Homo sapiens_hsa034303.21840959
8RNA transport_Homo sapiens_hsa030132.87777085
9Oxidative phosphorylation_Homo sapiens_hsa001902.83481533
10Pyrimidine metabolism_Homo sapiens_hsa002402.78000419
11Parkinsons disease_Homo sapiens_hsa050122.55843511
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.52995208
13Base excision repair_Homo sapiens_hsa034102.51836774
14Homologous recombination_Homo sapiens_hsa034402.41183112
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38255669
16Nucleotide excision repair_Homo sapiens_hsa034202.38025341
17Other glycan degradation_Homo sapiens_hsa005112.20744188
18Protein export_Homo sapiens_hsa030602.06272945
19Huntingtons disease_Homo sapiens_hsa050162.05515508
20Cell cycle_Homo sapiens_hsa041102.00591133
21Sulfur relay system_Homo sapiens_hsa041221.91547764
22One carbon pool by folate_Homo sapiens_hsa006701.67141352
23RNA degradation_Homo sapiens_hsa030181.58792444
24Basal transcription factors_Homo sapiens_hsa030221.57435343
25Alzheimers disease_Homo sapiens_hsa050101.54359801
26Purine metabolism_Homo sapiens_hsa002301.47911995
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.46834880
28Folate biosynthesis_Homo sapiens_hsa007901.42158868
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38702532
30Fanconi anemia pathway_Homo sapiens_hsa034601.34299634
31Notch signaling pathway_Homo sapiens_hsa043301.32855755
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32059536
33VEGF signaling pathway_Homo sapiens_hsa043701.30759630
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27808411
35mRNA surveillance pathway_Homo sapiens_hsa030151.27755742
36Vitamin B6 metabolism_Homo sapiens_hsa007501.23718524
37Oocyte meiosis_Homo sapiens_hsa041141.15600228
38Biosynthesis of amino acids_Homo sapiens_hsa012301.11278288
39p53 signaling pathway_Homo sapiens_hsa041151.08436024
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07576043
41Pentose phosphate pathway_Homo sapiens_hsa000301.04352655
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.04324871
43Epstein-Barr virus infection_Homo sapiens_hsa051691.04054569
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97790584
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96569746
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94674593
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.94015317
48Lysosome_Homo sapiens_hsa041420.93131913
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85054824
50Acute myeloid leukemia_Homo sapiens_hsa052210.83598230
51Non-homologous end-joining_Homo sapiens_hsa034500.82255001
52Cardiac muscle contraction_Homo sapiens_hsa042600.80954672
53Salmonella infection_Homo sapiens_hsa051320.79842939
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79426121
55Chronic myeloid leukemia_Homo sapiens_hsa052200.79329592
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78512210
57Collecting duct acid secretion_Homo sapiens_hsa049660.77965339
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77199031
59Insulin signaling pathway_Homo sapiens_hsa049100.76603505
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75574195
61AMPK signaling pathway_Homo sapiens_hsa041520.74565726
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74414519
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.74247055
64Vibrio cholerae infection_Homo sapiens_hsa051100.73091617
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70349080
66Regulation of autophagy_Homo sapiens_hsa041400.68682988
67Fructose and mannose metabolism_Homo sapiens_hsa000510.68572269
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.66422002
69Sulfur metabolism_Homo sapiens_hsa009200.66030656
70Endocytosis_Homo sapiens_hsa041440.65792957
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64223288
72Non-small cell lung cancer_Homo sapiens_hsa052230.63460824
73Carbon metabolism_Homo sapiens_hsa012000.63161113
74Dilated cardiomyopathy_Homo sapiens_hsa054140.61968844
75Metabolic pathways_Homo sapiens_hsa011000.58838161
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58747163
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56924018
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55819659
79B cell receptor signaling pathway_Homo sapiens_hsa046620.55749422
80Systemic lupus erythematosus_Homo sapiens_hsa053220.54220994
81Synaptic vesicle cycle_Homo sapiens_hsa047210.53788263
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53271593
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.51668879
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50009422
85Pancreatic cancer_Homo sapiens_hsa052120.48805514
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47929474
87Arginine and proline metabolism_Homo sapiens_hsa003300.46539046
88Thyroid cancer_Homo sapiens_hsa052160.45059648
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44961212
90Alcoholism_Homo sapiens_hsa050340.44521924
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42917135
92Axon guidance_Homo sapiens_hsa043600.42054876
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42042407
94Galactose metabolism_Homo sapiens_hsa000520.39833084
95Renal cell carcinoma_Homo sapiens_hsa052110.39542611
96ErbB signaling pathway_Homo sapiens_hsa040120.39463149
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39246085
98Glutathione metabolism_Homo sapiens_hsa004800.39240609
99Apoptosis_Homo sapiens_hsa042100.39164405
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.38839085
101Glioma_Homo sapiens_hsa052140.38830378
102N-Glycan biosynthesis_Homo sapiens_hsa005100.37950889
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.37927698
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36827557
105Antigen processing and presentation_Homo sapiens_hsa046120.35458847
106Hepatitis C_Homo sapiens_hsa051600.34294415
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.34197272
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34191718
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.33403898
110Pyruvate metabolism_Homo sapiens_hsa006200.33274773
111Viral carcinogenesis_Homo sapiens_hsa052030.33269572
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33146278
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32670822
114GnRH signaling pathway_Homo sapiens_hsa049120.31466550
115Endometrial cancer_Homo sapiens_hsa052130.29478834
116Melanogenesis_Homo sapiens_hsa049160.29041024
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28561755
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.28227596
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27549764
120Nicotine addiction_Homo sapiens_hsa050330.27474117
121Bladder cancer_Homo sapiens_hsa052190.26196110
122Circadian rhythm_Homo sapiens_hsa047100.25900363
123Focal adhesion_Homo sapiens_hsa045100.25855007
124mTOR signaling pathway_Homo sapiens_hsa041500.25793468
125Cocaine addiction_Homo sapiens_hsa050300.23806688
126HTLV-I infection_Homo sapiens_hsa051660.23598174
127Selenocompound metabolism_Homo sapiens_hsa004500.23337973
128Renin-angiotensin system_Homo sapiens_hsa046140.22827130
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22226990
130Hedgehog signaling pathway_Homo sapiens_hsa043400.16335223
131Shigellosis_Homo sapiens_hsa051310.16021671
132Phenylalanine metabolism_Homo sapiens_hsa003600.14353997
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12652878
134Tyrosine metabolism_Homo sapiens_hsa003500.12058118
135Prion diseases_Homo sapiens_hsa050200.08440267
136Primary immunodeficiency_Homo sapiens_hsa053400.07289806
137Hippo signaling pathway_Homo sapiens_hsa043900.06802527
138Herpes simplex infection_Homo sapiens_hsa051680.04750854
139Colorectal cancer_Homo sapiens_hsa052100.04112708
140Basal cell carcinoma_Homo sapiens_hsa052170.02816029
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.02213336
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02152243
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.01701580
144Legionellosis_Homo sapiens_hsa05134-0.0622602
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0599937
146GABAergic synapse_Homo sapiens_hsa04727-0.0584736
147Gap junction_Homo sapiens_hsa04540-0.0468320
148Wnt signaling pathway_Homo sapiens_hsa04310-0.0410640
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0363969
150Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0320351

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