ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.55339769
2	regulation of posttranscriptional gene silencing (GO:0060147)	5.21188682
3	regulation of gene silencing by miRNA (GO:0060964)	5.21188682
4	regulation of gene silencing by RNA (GO:0060966)	5.21188682
5	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.86109330
6	fucose catabolic process (GO:0019317)	3.64155195
7	L-fucose metabolic process (GO:0042354)	3.64155195
8	L-fucose catabolic process (GO:0042355)	3.64155195
9	negative regulation of telomere maintenance (GO:0032205)	3.62059072
10	nonmotile primary cilium assembly (GO:0035058)	3.52395691
11	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.50750897
12	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.50750897
13	regulation of translation, ncRNA-mediated (GO:0045974)	3.50750897
14	DNA deamination (GO:0045006)	3.34914663
15	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.30536669
16	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.28753792
17	reciprocal DNA recombination (GO:0035825)	3.25071656
18	reciprocal meiotic recombination (GO:0007131)	3.25071656
19	meiotic chromosome segregation (GO:0045132)	3.20565022
20	kynurenine metabolic process (GO:0070189)	3.15901666
21	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.10366585
22	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.10366585
23	regulation of mesoderm development (GO:2000380)	3.09483839
24	water-soluble vitamin biosynthetic process (GO:0042364)	3.08408470
25	response to pheromone (GO:0019236)	3.05540036
26	DNA replication checkpoint (GO:0000076)	3.05462720
27	kidney morphogenesis (GO:0060993)	2.96152907
28	ATP synthesis coupled proton transport (GO:0015986)	2.93300879
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.93300879
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.92671573
31	NADH dehydrogenase complex assembly (GO:0010257)	2.92671573
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.92671573
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.88000457
34	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87924535
35	ncRNA catabolic process (GO:0034661)	2.87831437
36	protein complex biogenesis (GO:0070271)	2.86657301
37	DNA methylation involved in gamete generation (GO:0043046)	2.85715095
38	sulfation (GO:0051923)	2.83196979
39	synapsis (GO:0007129)	2.80210299
40	indole-containing compound catabolic process (GO:0042436)	2.74049560
41	indolalkylamine catabolic process (GO:0046218)	2.74049560
42	tryptophan catabolic process (GO:0006569)	2.74049560
43	recombinational repair (GO:0000725)	2.73974141
44	double-strand break repair via homologous recombination (GO:0000724)	2.73587905
45	respiratory chain complex IV assembly (GO:0008535)	2.72905937
46	replication fork processing (GO:0031297)	2.72467703
47	translational termination (GO:0006415)	2.71884133
48	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.71575275
49	positive regulation of gastrulation (GO:2000543)	2.70839233
50	regulation of cilium movement (GO:0003352)	2.68434400
51	cell proliferation in forebrain (GO:0021846)	2.67913289
52	epithelial cilium movement (GO:0003351)	2.67537849
53	ribosomal small subunit assembly (GO:0000028)	2.66956118
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.66043314
55	protein-cofactor linkage (GO:0018065)	2.65915172
56	viral transcription (GO:0019083)	2.65159125
57	indolalkylamine metabolic process (GO:0006586)	2.64259566
58	DNA double-strand break processing (GO:0000729)	2.62944052
59	ubiquinone biosynthetic process (GO:0006744)	2.62357016
60	cytochrome complex assembly (GO:0017004)	2.58569797
61	detection of light stimulus involved in visual perception (GO:0050908)	2.57801637
62	detection of light stimulus involved in sensory perception (GO:0050962)	2.57801637
63	ubiquinone metabolic process (GO:0006743)	2.56356040
64	somite development (GO:0061053)	2.56307435
65	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.55665529
66	piRNA metabolic process (GO:0034587)	2.55576294
67	rRNA catabolic process (GO:0016075)	2.54523767
68	male meiosis I (GO:0007141)	2.52913079
69	nephron epithelium morphogenesis (GO:0072088)	2.51879419
70	nephron tubule morphogenesis (GO:0072078)	2.51879419
71	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51726784
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.49445032
73	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.49445032
74	regulation of telomere maintenance (GO:0032204)	2.49282851
75	protein polyglutamylation (GO:0018095)	2.48750440
76	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.48642665
77	cornea development in camera-type eye (GO:0061303)	2.46071724
78	centriole replication (GO:0007099)	2.45644733
79	hindbrain development (GO:0030902)	2.44618531
80	pseudouridine synthesis (GO:0001522)	2.43066453
81	somite rostral/caudal axis specification (GO:0032525)	2.43054092
82	regulation of meiosis I (GO:0060631)	2.40494567
83	regulation of hippo signaling (GO:0035330)	2.40459799
84	maturation of SSU-rRNA (GO:0030490)	2.39384301
85	positive regulation of histone H3-K4 methylation (GO:0051571)	2.37878082
86	neural tube formation (GO:0001841)	2.37739983
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.37062569
88	termination of RNA polymerase III transcription (GO:0006386)	2.37062569
89	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.35703386
90	DNA modification (GO:0006304)	2.33162279
91	photoreceptor cell maintenance (GO:0045494)	2.32497630
92	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.32143392
93	regulation of mitotic spindle checkpoint (GO:1903504)	2.32143392
94	head development (GO:0060322)	2.32128079
95	negative regulation by host of viral transcription (GO:0043922)	2.31485754
96	male meiosis (GO:0007140)	2.31243932
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.31181071
98	chromatin remodeling at centromere (GO:0031055)	2.30923516
99	lung-associated mesenchyme development (GO:0060484)	2.30674430
100	spinal cord development (GO:0021510)	2.30250015

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.28970839
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.10882081
3	VDR_22108803_ChIP-Seq_LS180_Human	3.10151906
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.69791738
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54771469
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.44878205
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.29530956
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28519653
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21017655
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.15460631
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09980042
12	EWS_26573619_Chip-Seq_HEK293_Human	2.09608891
13	MYC_18940864_ChIP-ChIP_HL60_Human	2.02686304
14	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.01563430
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.97931708
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94829348
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.93609128
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92548193
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.88310536
20	FUS_26573619_Chip-Seq_HEK293_Human	1.84116227
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.83604938
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.80316735
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76344641
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71892606
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.71676799
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68142615
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67003568
28	P300_19829295_ChIP-Seq_ESCs_Human	1.62204200
29	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.60322909
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57515016
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57515016
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56131558
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.55821162
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50673925
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50317600
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.49101772
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45733693
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43247620
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.37948787
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36414653
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31980495
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28354824
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27460250
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.27344347
45	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25398314
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24286775
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.23866202
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23594331
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20925232
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20292408
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20292408
52	ERA_21632823_ChIP-Seq_H3396_Human	1.17494530
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.16285357
54	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14378030
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13803759
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.13630636
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13405546
58	NCOR_22424771_ChIP-Seq_293T_Human	1.13381872
59	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13160119
60	TCF4_23295773_ChIP-Seq_U87_Human	1.11753192
61	STAT3_23295773_ChIP-Seq_U87_Human	1.11286954
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11039557
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10956593
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10474105
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10474105
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07081465
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.07081465
68	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06985304
69	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.05274012
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03519311
71	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03190511
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02451818
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.01845471
74	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.01285643
75	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00601327
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00366048
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99353364
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98939862
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98343938
80	E2F7_22180533_ChIP-Seq_HELA_Human	0.98274208
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.98214783
82	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98069353
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97877961
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97784556
85	AR_20517297_ChIP-Seq_VCAP_Human	0.97769679
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97461870
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.96826166
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96723791
89	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95041926
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94939410
91	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.94374661
92	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.94374661
93	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.94374661
94	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.94285157
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94109566
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92893773
97	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.90719771
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89681965
99	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89559913
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.89465829

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.62129397
2	MP0006292_abnormal_olfactory_placode	3.51811401
3	MP0008877_abnormal_DNA_methylation	3.19968410
4	MP0003646_muscle_fatigue	2.55907322
5	MP0002653_abnormal_ependyma_morphology	2.47179451
6	MP0003890_abnormal_embryonic-extraembry	2.34356679
7	MP0004133_heterotaxia	2.19663862
8	MP0002837_dystrophic_cardiac_calcinosis	1.97709739
9	MP0002254_reproductive_system_inflammat	1.97252185
10	MP0002938_white_spotting	1.91376178
11	MP0003787_abnormal_imprinting	1.91087362
12	MP0006276_abnormal_autonomic_nervous	1.89774029
13	MP0004147_increased_porphyrin_level	1.83040259
14	MP0001968_abnormal_touch/_nociception	1.82677093
15	MP0003195_calcinosis	1.82496653
16	MP0005645_abnormal_hypothalamus_physiol	1.78117769
17	MP0001293_anophthalmia	1.73706540
18	MP0005551_abnormal_eye_electrophysiolog	1.72059529
19	MP0008058_abnormal_DNA_repair	1.72037723
20	MP0006072_abnormal_retinal_apoptosis	1.69777134
21	MP0000631_abnormal_neuroendocrine_gland	1.69754996
22	MP0005377_hearing/vestibular/ear_phenot	1.68314230
23	MP0003878_abnormal_ear_physiology	1.68314230
24	MP0001485_abnormal_pinna_reflex	1.67206241
25	MP0002102_abnormal_ear_morphology	1.65138047
26	MP0003119_abnormal_digestive_system	1.61599552
27	MP0003718_maternal_effect	1.61419431
28	MP0008995_early_reproductive_senescence	1.60072323
29	MP0004142_abnormal_muscle_tone	1.58307748
30	MP0003937_abnormal_limbs/digits/tail_de	1.58056042
31	MP0004043_abnormal_pH_regulation	1.56143092
32	MP0003693_abnormal_embryo_hatching	1.51912253
33	MP0000049_abnormal_middle_ear	1.51154460
34	MP0009379_abnormal_foot_pigmentation	1.41089309
35	MP0004885_abnormal_endolymph	1.40293691
36	MP0002160_abnormal_reproductive_system	1.40228695
37	MP0001529_abnormal_vocalization	1.37002600
38	MP0002736_abnormal_nociception_after	1.33693837
39	MP0008872_abnormal_physiological_respon	1.33251978
40	MP0002272_abnormal_nervous_system	1.30676078
41	MP0000569_abnormal_digit_pigmentation	1.28187362
42	MP0005646_abnormal_pituitary_gland	1.27073685
43	MP0005389_reproductive_system_phenotype	1.26409450
44	MP0003283_abnormal_digestive_organ	1.26266453
45	MP0000427_abnormal_hair_cycle	1.25955408
46	MP0008789_abnormal_olfactory_epithelium	1.23042416
47	MP0002638_abnormal_pupillary_reflex	1.22545884
48	MP0001986_abnormal_taste_sensitivity	1.22527442
49	MP0009046_muscle_twitch	1.21934394
50	MP0004145_abnormal_muscle_electrophysio	1.21904099
51	MP0002163_abnormal_gland_morphology	1.21405823
52	MP0003880_abnormal_central_pattern	1.19942972
53	MP0009745_abnormal_behavioral_response	1.19032846
54	MP0002210_abnormal_sex_determination	1.17304695
55	MP0008057_abnormal_DNA_replication	1.16629005
56	MP0005253_abnormal_eye_physiology	1.16469030
57	MP0001919_abnormal_reproductive_system	1.14753873
58	MP0003121_genomic_imprinting	1.10932310
59	MP0003567_abnormal_fetal_cardiomyocyte	1.10494696
60	MP0002557_abnormal_social/conspecific_i	1.09844289
61	MP0005394_taste/olfaction_phenotype	1.09293330
62	MP0005499_abnormal_olfactory_system	1.09293330
63	MP0000778_abnormal_nervous_system	1.08751019
64	MP0002733_abnormal_thermal_nociception	1.07777623
65	MP0004742_abnormal_vestibular_system	1.06238167
66	MP0010094_abnormal_chromosome_stability	1.04801456
67	MP0001286_abnormal_eye_development	1.01674433
68	MP0003698_abnormal_male_reproductive	1.01632270
69	MP0002184_abnormal_innervation	0.99590996
70	MP0005195_abnormal_posterior_eye	0.96002409
71	MP0000372_irregular_coat_pigmentation	0.95199221
72	MP0000647_abnormal_sebaceous_gland	0.95139881
73	MP0002752_abnormal_somatic_nervous	0.95011605
74	MP0005174_abnormal_tail_pigmentation	0.94564342
75	MP0001929_abnormal_gametogenesis	0.93424176
76	MP0003938_abnormal_ear_development	0.90223057
77	MP0002751_abnormal_autonomic_nervous	0.90094919
78	MP0002735_abnormal_chemical_nociception	0.89941014
79	MP0002572_abnormal_emotion/affect_behav	0.89750009
80	MP0000955_abnormal_spinal_cord	0.89682114
81	MP0010030_abnormal_orbit_morphology	0.89158169
82	MP0008875_abnormal_xenobiotic_pharmacok	0.88580954
83	MP0000026_abnormal_inner_ear	0.88092308
84	MP0001970_abnormal_pain_threshold	0.87898518
85	MP0002095_abnormal_skin_pigmentation	0.87729261
86	MP0001145_abnormal_male_reproductive	0.87635480
87	MP0003011_delayed_dark_adaptation	0.87269236
88	MP0005410_abnormal_fertilization	0.86561649
89	MP0001486_abnormal_startle_reflex	0.85713539
90	MP0000653_abnormal_sex_gland	0.85593001
91	MP0008775_abnormal_heart_ventricle	0.83187151
92	MP0002234_abnormal_pharynx_morphology	0.83071269
93	MP0003861_abnormal_nervous_system	0.82426644
94	MP0003111_abnormal_nucleus_morphology	0.81812157
95	MP0001963_abnormal_hearing_physiology	0.79428637
96	MP0003635_abnormal_synaptic_transmissio	0.79356515
97	MP0001188_hyperpigmentation	0.78549846
98	MP0001501_abnormal_sleep_pattern	0.77877985
99	MP0000566_synostosis	0.76895441
100	MP0005084_abnormal_gallbladder_morpholo	0.75994178

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	3.70071490
2	Molar tooth sign on MRI (HP:0002419)	3.70071490
3	Pancreatic cysts (HP:0001737)	3.63216673
4	Pancreatic fibrosis (HP:0100732)	3.49225636
5	Nephronophthisis (HP:0000090)	3.39835883
6	Colon cancer (HP:0003003)	3.03375019
7	True hermaphroditism (HP:0010459)	2.98155510
8	Birth length less than 3rd percentile (HP:0003561)	2.96313215
9	Congenital stationary night blindness (HP:0007642)	2.91033890
10	Type II lissencephaly (HP:0007260)	2.86410274
11	Abnormal number of erythroid precursors (HP:0012131)	2.85272488
12	Abnormality of the renal medulla (HP:0100957)	2.79666073
13	Abnormality of cells of the erythroid lineage (HP:0012130)	2.76220140
14	Septo-optic dysplasia (HP:0100842)	2.73858610
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.60577175
16	Abnormality of alanine metabolism (HP:0010916)	2.60577175
17	Hyperalaninemia (HP:0003348)	2.60577175
18	Bilateral microphthalmos (HP:0007633)	2.58310451
19	Abnormality of the labia minora (HP:0012880)	2.57157976
20	Chronic hepatic failure (HP:0100626)	2.56262474
21	Medial flaring of the eyebrow (HP:0010747)	2.46919944
22	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.45682344
23	Reticulocytopenia (HP:0001896)	2.45594970
24	Patellar aplasia (HP:0006443)	2.45304078
25	Concave nail (HP:0001598)	2.43630257
26	Pendular nystagmus (HP:0012043)	2.42289026
27	Cerebellar dysplasia (HP:0007033)	2.40997824
28	Tubular atrophy (HP:0000092)	2.38670275
29	Protruding tongue (HP:0010808)	2.38666223
30	Attenuation of retinal blood vessels (HP:0007843)	2.37382910
31	Abolished electroretinogram (ERG) (HP:0000550)	2.36373373
32	Abnormality of the renal cortex (HP:0011035)	2.33524793
33	Sclerocornea (HP:0000647)	2.33095180
34	Aplasia/Hypoplasia of the patella (HP:0006498)	2.31800206
35	Abnormal drinking behavior (HP:0030082)	2.29625047
36	Polydipsia (HP:0001959)	2.29625047
37	Hypoplasia of the pons (HP:0012110)	2.25245949
38	Optic nerve hypoplasia (HP:0000609)	2.24133983
39	Cystic liver disease (HP:0006706)	2.21388942
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20531521
41	Abnormality of the pons (HP:0007361)	2.18631778
42	Anencephaly (HP:0002323)	2.14795394
43	Inability to walk (HP:0002540)	2.13697609
44	Lissencephaly (HP:0001339)	2.11564219
45	Bile duct proliferation (HP:0001408)	2.10089304
46	Abnormal biliary tract physiology (HP:0012439)	2.10089304
47	Absent thumb (HP:0009777)	2.09173341
48	Rib fusion (HP:0000902)	2.08511583
49	Meckel diverticulum (HP:0002245)	2.05808839
50	Abnormality of the ileum (HP:0001549)	2.04794135
51	Acute necrotizing encephalopathy (HP:0006965)	2.03882921
52	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.03854595
53	Partial agenesis of the corpus callosum (HP:0001338)	2.03244364
54	Decreased central vision (HP:0007663)	2.02687424
55	Ectopic kidney (HP:0000086)	2.01116437
56	Clumsiness (HP:0002312)	1.99470896
57	Bony spicule pigmentary retinopathy (HP:0007737)	1.98670676
58	Mitochondrial inheritance (HP:0001427)	1.96085137
59	Polyuria (HP:0000103)	1.95657601
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94791448
61	Absent/shortened dynein arms (HP:0200106)	1.94791448
62	Chromsome breakage (HP:0040012)	1.94505273
63	Hyperglycinuria (HP:0003108)	1.93310796
64	Hyperventilation (HP:0002883)	1.92968495
65	Triphalangeal thumb (HP:0001199)	1.90605614
66	Vaginal atresia (HP:0000148)	1.89878377
67	Anophthalmia (HP:0000528)	1.89553040
68	Gait imbalance (HP:0002141)	1.88402560
69	Congenital primary aphakia (HP:0007707)	1.86702845
70	3-Methylglutaconic aciduria (HP:0003535)	1.86376387
71	Acute encephalopathy (HP:0006846)	1.85789245
72	Genital tract atresia (HP:0001827)	1.85168434
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.83691944
74	Broad-based gait (HP:0002136)	1.82171518
75	Increased CSF lactate (HP:0002490)	1.81300206
76	Nephrogenic diabetes insipidus (HP:0009806)	1.80942633
77	Abnormality of the renal collecting system (HP:0004742)	1.79954781
78	Congenital, generalized hypertrichosis (HP:0004540)	1.79286925
79	Hyperglycinemia (HP:0002154)	1.76896155
80	Postaxial foot polydactyly (HP:0001830)	1.75465386
81	Stenosis of the external auditory canal (HP:0000402)	1.74084109
82	Congenital hepatic fibrosis (HP:0002612)	1.73812129
83	Progressive inability to walk (HP:0002505)	1.72836997
84	Lipid accumulation in hepatocytes (HP:0006561)	1.72834247
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.72187455
86	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71741729
87	Dandy-Walker malformation (HP:0001305)	1.71161142
88	Small hand (HP:0200055)	1.70005512
89	Short hallux (HP:0010109)	1.67626544
90	Abnormal mitochondria in muscle tissue (HP:0008316)	1.67290315
91	Genetic anticipation (HP:0003743)	1.67211513
92	Preaxial hand polydactyly (HP:0001177)	1.66592184
93	Poor coordination (HP:0002370)	1.66129732
94	Increased hepatocellular lipid droplets (HP:0006565)	1.65964382
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.65547394
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.65547394
97	Absent septum pellucidum (HP:0001331)	1.65474199
98	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.65335362
99	Progressive cerebellar ataxia (HP:0002073)	1.64823350
100	Abnormality of homocysteine metabolism (HP:0010919)	1.64308411

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.74640395
2	FRK	3.54655785
3	WNK4	3.12652212
4	BMPR1B	2.90210090
5	ADRBK2	2.78929634
6	TLK1	2.48923577
7	INSRR	2.30470419
8	GRK1	2.21638707
9	MKNK2	2.12235490
10	NUAK1	2.02607697
11	ACVR1B	2.00602302
12	WNK3	1.91979565
13	CASK	1.86693361
14	MAP3K4	1.84812038
15	CDC7	1.83213531
16	TAF1	1.82460834
17	TNIK	1.79725517
18	NEK2	1.79531870
19	STK38L	1.77710009
20	VRK2	1.70609043
21	PINK1	1.67357025
22	DYRK2	1.59571519
23	PLK4	1.57799100
24	MKNK1	1.56503197
25	MAP4K2	1.48448695
26	CAMK1D	1.47753197
27	TAOK3	1.40090697
28	OXSR1	1.34553690
29	CAMK1G	1.26684771
30	VRK1	1.26248056
31	PNCK	1.19402130
32	CDK19	1.18908443
33	NME1	1.17378832
34	TTK	1.17318978
35	TGFBR1	1.15692388
36	DYRK3	1.09706837
37	DAPK2	1.07830201
38	TXK	1.06736997
39	CHEK2	1.05651416
40	AKT3	1.05508793
41	MAP3K9	1.01081449
42	MAP2K7	0.99892555
43	PRKCG	0.99211929
44	STK3	0.96730446
45	MAPK15	0.94234229
46	ATR	0.89993953
47	TYRO3	0.87862296
48	ADRBK1	0.87654169
49	PLK3	0.87227910
50	FGFR2	0.86288744
51	NLK	0.84848081
52	MAPK13	0.84631048
53	PLK1	0.82999425
54	BRSK2	0.82444533
55	SIK2	0.81324986
56	PASK	0.80600926
57	STK39	0.79465615
58	TIE1	0.77229505
59	LATS1	0.75736949
60	CSNK1G1	0.72625920
61	CAMK1	0.69167660
62	RPS6KA5	0.68532833
63	STK16	0.65736296
64	TEC	0.64212400
65	STK11	0.64189524
66	TSSK6	0.63987732
67	NTRK3	0.62874401
68	WNK1	0.62605487
69	PRKCE	0.61786577
70	BCKDK	0.59052780
71	CSNK1A1L	0.58201518
72	SRPK1	0.57288536
73	MAPKAPK5	0.56890385
74	ATM	0.56692533
75	CSNK1G2	0.56333434
76	RPS6KA6	0.55638773
77	CSNK1G3	0.55506505
78	WEE1	0.55224678
79	PAK3	0.54487742
80	MARK1	0.47845157
81	CSNK1A1	0.46350353
82	DYRK1A	0.45701309
83	NTRK2	0.45467853
84	PRKCI	0.43995825
85	PLK2	0.43410777
86	BUB1	0.43261113
87	PIM1	0.41996604
88	CSNK1E	0.41231928
89	BMX	0.40949560
90	PRKAA1	0.39334942
91	PRKACA	0.36940146
92	AURKA	0.36450939
93	AURKB	0.32838067
94	FLT3	0.32730068
95	PRKAA2	0.32590443
96	CSNK1D	0.31973425
97	CHUK	0.30515304
98	MUSK	0.29813029
99	PIK3CA	0.29204613
100	CDK2	0.28991639

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	2.95438487
2	Homologous recombination_Homo sapiens_hsa03440	2.68726428
3	RNA polymerase_Homo sapiens_hsa03020	2.61209269
4	Phototransduction_Homo sapiens_hsa04744	2.51819356
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.50945266
6	Basal transcription factors_Homo sapiens_hsa03022	2.46847578
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33845387
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.28843921
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.27129304
10	Nicotine addiction_Homo sapiens_hsa05033	2.16458868
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16225468
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16050275
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.11233069
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.07372830
15	Parkinsons disease_Homo sapiens_hsa05012	1.98789062
16	One carbon pool by folate_Homo sapiens_hsa00670	1.93290240
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82256855
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.81996905
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79696682
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77382366
21	Butanoate metabolism_Homo sapiens_hsa00650	1.69712392
22	Huntingtons disease_Homo sapiens_hsa05016	1.68433255
23	RNA degradation_Homo sapiens_hsa03018	1.63280363
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62318130
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59002942
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.54464062
27	Caffeine metabolism_Homo sapiens_hsa00232	1.51383539
28	Olfactory transduction_Homo sapiens_hsa04740	1.48219515
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46648618
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39533397
31	Taste transduction_Homo sapiens_hsa04742	1.36706441
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.28048455
33	Alzheimers disease_Homo sapiens_hsa05010	1.22485018
34	Morphine addiction_Homo sapiens_hsa05032	1.20117163
35	Mismatch repair_Homo sapiens_hsa03430	1.18251490
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.15595329
37	Basal cell carcinoma_Homo sapiens_hsa05217	1.15497319
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14076235
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13130800
40	RNA transport_Homo sapiens_hsa03013	1.12716331
41	DNA replication_Homo sapiens_hsa03030	1.07904048
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.06366542
43	Protein export_Homo sapiens_hsa03060	1.03615477
44	Purine metabolism_Homo sapiens_hsa00230	0.99148486
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96680367
46	Base excision repair_Homo sapiens_hsa03410	0.95900370
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95856930
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91614379
49	Propanoate metabolism_Homo sapiens_hsa00640	0.91464987
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90958003
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.90479500
52	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.89487955
53	Retinol metabolism_Homo sapiens_hsa00830	0.89156218
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.87874885
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86343672
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86215094
57	GABAergic synapse_Homo sapiens_hsa04727	0.85885682
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.84331951
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.84315050
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84064372
61	Spliceosome_Homo sapiens_hsa03040	0.81987655
62	Serotonergic synapse_Homo sapiens_hsa04726	0.81766486
63	ABC transporters_Homo sapiens_hsa02010	0.81463445
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.80177106
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.79870281
66	Peroxisome_Homo sapiens_hsa04146	0.78144959
67	Insulin secretion_Homo sapiens_hsa04911	0.76637861
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75809354
69	Sulfur relay system_Homo sapiens_hsa04122	0.66087197
70	Metabolic pathways_Homo sapiens_hsa01100	0.65971342
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65387341
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64988189
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63695793
74	Circadian entrainment_Homo sapiens_hsa04713	0.63506721
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61304325
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60972707
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60668621
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60076660
79	Proteasome_Homo sapiens_hsa03050	0.58448637
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.57405231
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56510269
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.55092582
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.53175004
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50210585
85	Lysine degradation_Homo sapiens_hsa00310	0.50196343
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48091387
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47179759
88	Cell cycle_Homo sapiens_hsa04110	0.46993624
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44423645
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44146726
91	mRNA surveillance pathway_Homo sapiens_hsa03015	0.43070203
92	Alcoholism_Homo sapiens_hsa05034	0.42508266
93	p53 signaling pathway_Homo sapiens_hsa04115	0.42214571
94	Regulation of autophagy_Homo sapiens_hsa04140	0.40902922
95	Long-term depression_Homo sapiens_hsa04730	0.40684486
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39140276
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.38654869
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37950020
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36529452
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33936242

TSSC2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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