TSSC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.35711567
2Golgi transport vesicle coating (GO:0048200)8.35711567
3protein maturation by protein folding (GO:0022417)6.27571797
4DNA deamination (GO:0045006)6.08628420
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.45031673
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.10625475
7signal peptide processing (GO:0006465)4.95693263
8protein retention in ER lumen (GO:0006621)4.73879762
9endocrine pancreas development (GO:0031018)4.60168849
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.56910151
11GDP-mannose metabolic process (GO:0019673)4.54720195
12COPII vesicle coating (GO:0048208)4.52435561
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.42908790
14folic acid-containing compound biosynthetic process (GO:0009396)4.34342070
15NIK/NF-kappaB signaling (GO:0038061)4.21989063
16regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.07285973
17negative regulation of glycoprotein biosynthetic process (GO:0010561)4.04254568
18DNA strand elongation involved in DNA replication (GO:0006271)4.01002887
19glandular epithelial cell differentiation (GO:0002067)3.88000005
20negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.85463586
21L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.83251116
22telomere maintenance via semi-conservative replication (GO:0032201)3.83214499
23DNA strand elongation (GO:0022616)3.81199441
24pteridine-containing compound biosynthetic process (GO:0042559)3.76644352
25purine deoxyribonucleotide catabolic process (GO:0009155)3.75185062
26regulation of type B pancreatic cell apoptotic process (GO:2000674)3.72649855
27peptide hormone processing (GO:0016486)3.72295197
28proteasome assembly (GO:0043248)3.68841490
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63266833
30peptidyl-histidine modification (GO:0018202)3.58240643
31cotranslational protein targeting to membrane (GO:0006613)3.57114956
32protein targeting to ER (GO:0045047)3.55535501
33positive regulation of nuclease activity (GO:0032075)3.53422886
34activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.47931788
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41581668
36DNA replication initiation (GO:0006270)3.40978290
37exocrine pancreas development (GO:0031017)3.37773017
38protein localization to endoplasmic reticulum (GO:0070972)3.37534520
39sequestering of metal ion (GO:0051238)3.34455179
40GMP metabolic process (GO:0046037)3.29022613
41ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.27500332
42regulation of nuclease activity (GO:0032069)3.26220903
43viral protein processing (GO:0019082)3.23903478
44protein N-linked glycosylation via asparagine (GO:0018279)3.23160377
45response to peptidoglycan (GO:0032494)3.20503570
46deoxyribonucleotide catabolic process (GO:0009264)3.18889731
47vesicle coating (GO:0006901)3.17528893
48peptidyl-asparagine modification (GO:0018196)3.17049319
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15665723
50proline biosynthetic process (GO:0006561)3.13519771
51positive regulation of insulin secretion (GO:0032024)3.13255676
52virion assembly (GO:0019068)3.11316619
53negative regulation of myeloid cell apoptotic process (GO:0033033)3.08336196
54pyrimidine-containing compound salvage (GO:0008655)3.07441584
55pyrimidine nucleoside salvage (GO:0043097)3.07441584
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04812705
57barbed-end actin filament capping (GO:0051016)3.04578712
58protein N-linked glycosylation (GO:0006487)3.04242361
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01919472
60telomere maintenance via recombination (GO:0000722)3.01657152
61DNA unwinding involved in DNA replication (GO:0006268)3.00604345
62pentose-phosphate shunt (GO:0006098)3.00035095
63deoxyribose phosphate catabolic process (GO:0046386)2.99095151
64UV protection (GO:0009650)2.98200213
65ribosomal small subunit assembly (GO:0000028)2.96833298
66amino sugar catabolic process (GO:0046348)2.96330989
67peptidyl-arginine omega-N-methylation (GO:0035247)2.94896485
68cellular response to arsenic-containing substance (GO:0071243)2.91760378
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91682180
70negative regulation of cell killing (GO:0031342)2.91682180
71negative regulation of glycoprotein metabolic process (GO:1903019)2.90673311
72negative regulation of erythrocyte differentiation (GO:0045647)2.90380805
73ER to Golgi vesicle-mediated transport (GO:0006888)2.89821628
74endoplasmic reticulum unfolded protein response (GO:0030968)2.89695000
75dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.89123271
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88375757
77negative regulation of ligase activity (GO:0051352)2.88375757
78cellular response to topologically incorrect protein (GO:0035967)2.87886099
79deoxyribose phosphate biosynthetic process (GO:0046385)2.85190907
802-deoxyribonucleotide biosynthetic process (GO:0009265)2.85190907
81pinocytosis (GO:0006907)2.84970142
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.84781630
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.83650048
84termination of RNA polymerase III transcription (GO:0006386)2.83650048
85regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83525380
86negative regulation of B cell apoptotic process (GO:0002903)2.82234352
87nucleotide salvage (GO:0043173)2.81835600
88activation of MAPKKK activity (GO:0000185)2.81499507
89nuclear envelope reassembly (GO:0031468)2.81485041
90mitotic nuclear envelope reassembly (GO:0007084)2.81485041
91protein peptidyl-prolyl isomerization (GO:0000413)2.81379280
92cellular response to unfolded protein (GO:0034620)2.81063918
93establishment of integrated proviral latency (GO:0075713)2.80444006
94mature B cell differentiation involved in immune response (GO:0002313)2.80168627
95spliceosomal complex assembly (GO:0000245)2.79788885
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79547849
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79547849
98mannosylation (GO:0097502)2.79231907
99amino acid salvage (GO:0043102)2.77511402
100L-methionine salvage (GO:0071267)2.77511402
101L-methionine biosynthetic process (GO:0071265)2.77511402
102protein autoprocessing (GO:0016540)2.76955836
103mitotic recombination (GO:0006312)2.76297972
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76248216
105modulation by symbiont of host cellular process (GO:0044068)2.75830659
106translation (GO:0006412)2.75047752
107deoxyribonucleotide biosynthetic process (GO:0009263)2.74845606
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73624396
109negative regulation of DNA-templated transcription, elongation (GO:0032785)2.73458133
110positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.72552246
111pentose metabolic process (GO:0019321)2.72541553
112regulation of autophagic vacuole assembly (GO:2000785)2.71918327
113cullin deneddylation (GO:0010388)2.71880510
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71669481
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70860861
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70020529
117iron-sulfur cluster assembly (GO:0016226)2.69744332
118metallo-sulfur cluster assembly (GO:0031163)2.69744332
119negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69706938
120regulation of release of cytochrome c from mitochondria (GO:0090199)2.69345450
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69249820
122protein deneddylation (GO:0000338)2.69058867
123transcription-coupled nucleotide-excision repair (GO:0006283)2.67834028
124immunoglobulin mediated immune response (GO:0016064)2.67715409
125protein localization to endosome (GO:0036010)2.67628744
126negative regulation of interleukin-12 production (GO:0032695)2.67092637
127cellular response to hepatocyte growth factor stimulus (GO:0035729)2.66385358
128response to hepatocyte growth factor (GO:0035728)2.66385358
129nucleoside diphosphate catabolic process (GO:0009134)2.65728804
130nucleobase biosynthetic process (GO:0046112)2.64932849
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64839202
132glucose catabolic process (GO:0006007)2.64287856
133spliceosomal snRNP assembly (GO:0000387)2.64252165
134chaperone mediated protein folding requiring cofactor (GO:0051085)2.64096051
135regulation of mitochondrial membrane potential (GO:0051881)2.63774160
136positive regulation by symbiont of host defense response (GO:0052509)2.63656684
137modulation by symbiont of host defense response (GO:0052031)2.63656684
138modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63656684
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63656684
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.63656684
141modulation by symbiont of host immune response (GO:0052553)2.63656684
142ER-nucleus signaling pathway (GO:0006984)2.63295032
143purine-containing compound salvage (GO:0043101)2.62654172
144pseudouridine synthesis (GO:0001522)2.61823091
145modulation by virus of host process (GO:0019054)2.60427495
146negative regulation of tumor necrosis factor production (GO:0032720)2.60344473
147regulation of superoxide anion generation (GO:0032928)2.58204521
148regulation of necrotic cell death (GO:0010939)2.57555011
149negative regulation of interleukin-2 production (GO:0032703)2.56586105
150ER overload response (GO:0006983)2.55264609
151deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.54736468
152base-excision repair, AP site formation (GO:0006285)2.54492600
153histone arginine methylation (GO:0034969)2.54154786
154protein insertion into membrane (GO:0051205)2.53935526
155DNA replication checkpoint (GO:0000076)2.53139008
156pyrimidine nucleotide catabolic process (GO:0006244)2.52776015
157negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.52633758
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51577180
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.50930990
160NADPH regeneration (GO:0006740)2.49854163
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48925854
162response to muramyl dipeptide (GO:0032495)2.47090842
163antigen processing and presentation of endogenous antigen (GO:0019883)2.45865472
1643-UTR-mediated mRNA stabilization (GO:0070935)2.43697598
165type I interferon signaling pathway (GO:0060337)2.43632556
166cellular response to type I interferon (GO:0071357)2.43632556
167negative regulation of cell size (GO:0045792)2.42816355
168negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42494093
169endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40253465
170prostanoid biosynthetic process (GO:0046457)2.40179465
171prostaglandin biosynthetic process (GO:0001516)2.40179465
172rRNA transcription (GO:0009303)2.37901756
173regulation of mast cell degranulation (GO:0043304)2.37022712
174response to type I interferon (GO:0034340)2.34995661
175endothelial tube morphogenesis (GO:0061154)2.34463093
176morphogenesis of an endothelium (GO:0003159)2.34463093
177interferon-gamma secretion (GO:0072643)2.34077555
178neutrophil activation involved in immune response (GO:0002283)2.33751209
179ribosomal small subunit biogenesis (GO:0042274)2.32683078
180purine nucleotide salvage (GO:0032261)2.32241567
1812-deoxyribonucleotide metabolic process (GO:0009394)2.31641932
182negative regulation of mitochondrion organization (GO:0010823)2.30902182
183negative regulation of viral release from host cell (GO:1902187)2.26484808
184negative regulation of nitric oxide biosynthetic process (GO:0045019)2.25585001
185antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.25525099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.44490106
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86349774
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.71519113
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69478615
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66859598
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.62982404
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.32886336
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.11173162
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.06556085
10* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05943623
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.95833544
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77570328
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75716487
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72400775
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65930963
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.65147694
17XRN2_22483619_ChIP-Seq_HELA_Human2.48340056
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47254156
19* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41666238
20DCP1A_22483619_ChIP-Seq_HELA_Human2.32032546
21* GABP_19822575_ChIP-Seq_HepG2_Human2.31926444
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31109910
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20466744
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18432156
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.18171070
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17174898
27* ELK3_25401928_ChIP-Seq_HUVEC_Human2.14261063
28* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.11855629
29VDR_23849224_ChIP-Seq_CD4+_Human2.11805547
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08773082
31MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04576468
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02438640
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99522920
34FOXP3_21729870_ChIP-Seq_TREG_Human1.95937653
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.94089620
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93130742
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93035606
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.90579118
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83431477
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.83385020
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83214315
42CIITA_25753668_ChIP-Seq_RAJI_Human1.79927003
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.74648325
44ZNF263_19887448_ChIP-Seq_K562_Human1.73636920
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72603226
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71690807
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70286156
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69863943
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66965975
50TTF2_22483619_ChIP-Seq_HELA_Human1.64620749
51* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62720254
52* VDR_24763502_ChIP-Seq_THP-1_Human1.62535828
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59981077
54* MYC_22102868_ChIP-Seq_BL_Human1.59636403
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59457808
56* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59252053
57* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59147666
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58705661
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52946289
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51236144
61RACK7_27058665_Chip-Seq_MCF-7_Human1.50506990
62* MAF_26560356_Chip-Seq_TH2_Human1.50113187
63* MAF_26560356_Chip-Seq_TH1_Human1.48541712
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46080103
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45611700
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.45453978
67BCL6_27268052_Chip-Seq_Bcells_Human1.44353756
68* UTX_26944678_Chip-Seq_JUKART_Human1.43078631
69KDM2B_26808549_Chip-Seq_DND41_Human1.42562752
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42207936
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41199141
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40859066
73BCOR_27268052_Chip-Seq_Bcells_Human1.40607918
74* VDR_21846776_ChIP-Seq_THP-1_Human1.39326003
75TFEB_21752829_ChIP-Seq_HELA_Human1.38633697
76* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37819534
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37214967
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37110998
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.36889676
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36450838
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.36094355
82* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35766657
83* SA1_27219007_Chip-Seq_ERYTHROID_Human1.34779736
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32697299
85* KDM5A_27292631_Chip-Seq_BREAST_Human1.32361440
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31939947
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30849603
88* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30843940
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30068087
90* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29351848
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28855425
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28629657
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27771796
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27586384
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.27260721
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27153639
97TCF7_22412390_ChIP-Seq_EML_Mouse1.26301552
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25445001
99* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24470932
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.23622543
101* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22776841
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21144541
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18015128
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17927742
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16536590
106SPI1_23547873_ChIP-Seq_NB4_Human1.15629721
107ELK1_19687146_ChIP-ChIP_HELA_Human1.15461701
108* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14647128
109* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14645122
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.14585548
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.14278730
112* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12409357
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12094364
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12044898
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.11111010
116* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09896413
117* CTCF_21964334_Chip-Seq_Bcells_Human1.08688705
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08074392
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08004218
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06715840
121* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06535576
122TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06339126
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06038948
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05753885
125PHF8_20622854_ChIP-Seq_HELA_Human1.05731240
126TP63_17297297_ChIP-ChIP_HaCaT_Human1.05097851
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04886405
128NCOR1_26117541_ChIP-Seq_K562_Human1.03946907
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03944781
130FOXM1_23109430_ChIP-Seq_U2OS_Human1.02845343
131* ELK1_22589737_ChIP-Seq_MCF10A_Human1.02415735
132* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01793375
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97987756
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.97551865
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96092759
136* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95381538
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89155638
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87761292
139AR_21909140_ChIP-Seq_LNCAP_Human0.87248324
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85849845
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.84171701
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83893724
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.83161289
144* LXR_22292898_ChIP-Seq_THP-1_Human0.81912974
145P68_20966046_ChIP-Seq_HELA_Human0.80899518
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80183356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.11771298
2MP0005451_abnormal_body_composition3.45824094
3MP0000678_abnormal_parathyroid_gland3.38479199
4MP0008260_abnormal_autophagy3.35646592
5MP0002877_abnormal_melanocyte_morpholog3.27805375
6MP0003436_decreased_susceptibility_to3.26891203
7MP0002693_abnormal_pancreas_physiology3.18493876
8MP0003693_abnormal_embryo_hatching3.16494972
9MP0004043_abnormal_pH_regulation3.08415936
10MP0001944_abnormal_pancreas_morphology3.07311629
11MP0003303_peritoneal_inflammation2.97165648
12MP0005220_abnormal_exocrine_pancreas2.96610359
13MP0006072_abnormal_retinal_apoptosis2.73099054
14MP0000013_abnormal_adipose_tissue2.70159889
15MP0009840_abnormal_foam_cell2.70044031
16MP0006292_abnormal_olfactory_placode2.67171144
17MP0000462_abnormal_digestive_system2.60952486
18MP0003183_abnormal_peptide_metabolism2.56672663
19MP0002909_abnormal_adrenal_gland2.51209819
20MP0004957_abnormal_blastocyst_morpholog2.50121214
21MP0009278_abnormal_bone_marrow2.36113130
22MP0001986_abnormal_taste_sensitivity2.32532130
23MP0010386_abnormal_urinary_bladder2.30226230
24MP0001835_abnormal_antigen_presentation2.21094778
25MP0002148_abnormal_hypersensitivity_rea2.17673864
26MP0005025_abnormal_response_to2.16857212
27MP0005000_abnormal_immune_tolerance2.14424217
28MP0009785_altered_susceptibility_to2.13935789
29MP0002653_abnormal_ependyma_morphology2.10351597
30MP0005379_endocrine/exocrine_gland_phen2.00884574
31MP0008057_abnormal_DNA_replication1.99444513
32MP0002419_abnormal_innate_immunity1.99112722
33MP0004510_myositis1.98772454
34MP0003191_abnormal_cellular_cholesterol1.97407615
35MP0008058_abnormal_DNA_repair1.93270155
36MP0004133_heterotaxia1.92059085
37MP0003724_increased_susceptibility_to1.88606690
38MP0008932_abnormal_embryonic_tissue1.88420582
39MP0000685_abnormal_immune_system1.87568814
40MP0003763_abnormal_thymus_physiology1.81679627
41MP0005671_abnormal_response_to1.80752237
42MP0002723_abnormal_immune_serum1.79589171
43MP0004858_abnormal_nervous_system1.77260438
44MP0001790_abnormal_immune_system1.76983869
45MP0005387_immune_system_phenotype1.76983869
46MP0003077_abnormal_cell_cycle1.76526294
47MP0003172_abnormal_lysosome_physiology1.75990175
48MP0003122_maternal_imprinting1.75843784
49MP0005464_abnormal_platelet_physiology1.73401150
50MP0004947_skin_inflammation1.72852502
51MP0010094_abnormal_chromosome_stability1.72826809
52MP0000858_altered_metastatic_potential1.71763302
53MP0003195_calcinosis1.71332786
54MP0002452_abnormal_antigen_presenting1.69698048
55MP0002420_abnormal_adaptive_immunity1.69132508
56MP0001819_abnormal_immune_cell1.69019539
57MP0000343_altered_response_to1.67769917
58MP0006054_spinal_hemorrhage1.63352673
59MP0001800_abnormal_humoral_immune1.61969328
60MP0003075_altered_response_to1.61373037
61MP0003111_abnormal_nucleus_morphology1.60020372
62MP0001533_abnormal_skeleton_physiology1.56228045
63MP0006082_CNS_inflammation1.55407341
64MP0000537_abnormal_urethra_morphology1.54059917
65MP0009780_abnormal_chondrocyte_physiolo1.53734231
66MP0005397_hematopoietic_system_phenotyp1.53119516
67MP0001545_abnormal_hematopoietic_system1.53119516
68MP0008007_abnormal_cellular_replicative1.47989237
69MP0002332_abnormal_exercise_endurance1.42383365
70MP0002398_abnormal_bone_marrow1.38758177
71MP0002078_abnormal_glucose_homeostasis1.38690983
72MP0000613_abnormal_salivary_gland1.38618048
73MP0000716_abnormal_immune_system1.36871613
74MP0000003_abnormal_adipose_tissue1.36080663
75MP0009764_decreased_sensitivity_to1.35808804
76MP0003119_abnormal_digestive_system1.32138047
77MP0001730_embryonic_growth_arrest1.31855547
78MP0001845_abnormal_inflammatory_respons1.30190587
79MP0002429_abnormal_blood_cell1.28882918
80MP0000750_abnormal_muscle_regeneration1.28742823
81MP0001853_heart_inflammation1.27200877
82MP0002722_abnormal_immune_system1.26417679
83MP0008469_abnormal_protein_level1.26071313
84MP0000604_amyloidosis1.25940375
85MP0000681_abnormal_thyroid_gland1.25830913
86MP0003806_abnormal_nucleotide_metabolis1.25551543
87MP0003705_abnormal_hypodermis_morpholog1.24483093
88MP0002405_respiratory_system_inflammati1.23691933
89MP0010155_abnormal_intestine_physiology1.23199971
90MP0002638_abnormal_pupillary_reflex1.21751206
91MP0000631_abnormal_neuroendocrine_gland1.21359745
92MP0003453_abnormal_keratinocyte_physiol1.21337326
93MP0002234_abnormal_pharynx_morphology1.20628678
94MP0006036_abnormal_mitochondrial_physio1.20226594
95MP0003866_abnormal_defecation1.18029930
96MP0000689_abnormal_spleen_morphology1.17522192
97MP0000358_abnormal_cell_content/1.17412509
98MP0002751_abnormal_autonomic_nervous1.15931662
99MP0009672_abnormal_birth_weight1.15659893
100MP0003329_amyloid_beta_deposits1.14584682
101MP0003186_abnormal_redox_activity1.14500368
102MP0001542_abnormal_bone_strength1.13986718
103MP0001849_ear_inflammation1.13424992
104MP0009333_abnormal_splenocyte_physiolog1.13089961
105MP0000751_myopathy1.10667647
106MP0002998_abnormal_bone_remodeling1.10619456
107MP0003656_abnormal_erythrocyte_physiolo1.09543330
108MP0001529_abnormal_vocalization1.07230036
109MP0003011_delayed_dark_adaptation1.07062001
110MP0003300_gastrointestinal_ulcer1.05360507
111MP0000490_abnormal_crypts_of1.03604350
112MP0000313_abnormal_cell_death1.03596544
113MP0002080_prenatal_lethality1.03397167
114MP0004185_abnormal_adipocyte_glucose0.98571332
115MP0005058_abnormal_lysosome_morphology0.96391985
116MP0005501_abnormal_skin_physiology0.96243002
117MP0005253_abnormal_eye_physiology0.95078477
118MP0009643_abnormal_urine_homeostasis0.93988713
119MP0004264_abnormal_extraembryonic_tissu0.93134899
120MP0002132_abnormal_respiratory_system0.92554197
121MP0005083_abnormal_biliary_tract0.91521618
122MP0004233_abnormal_muscle_weight0.91024507
123MP0001873_stomach_inflammation0.89425564
124MP0008874_decreased_physiological_sensi0.89068066
125MP0005165_increased_susceptibility_to0.86803327
126MP0001697_abnormal_embryo_size0.86706472
127MP0006035_abnormal_mitochondrial_morpho0.86538564
128MP0003123_paternal_imprinting0.86320915
129MP0003279_aneurysm0.85949601
130MP0002837_dystrophic_cardiac_calcinosis0.85300645
131MP0002085_abnormal_embryonic_tissue0.84739782
132MP0002019_abnormal_tumor_incidence0.84679600
133MP0000350_abnormal_cell_proliferation0.84435701
134MP0005584_abnormal_enzyme/coenzyme_acti0.84301759
135MP0005330_cardiomyopathy0.83562957
136MP0008877_abnormal_DNA_methylation0.82493813
137MP0000955_abnormal_spinal_cord0.82159352
138MP0005375_adipose_tissue_phenotype0.82142491
139MP0003448_altered_tumor_morphology0.81985442
140MP0004142_abnormal_muscle_tone0.81851419
141MP0005166_decreased_susceptibility_to0.81489933
142MP0002163_abnormal_gland_morphology0.81229104
143MP0005390_skeleton_phenotype0.80456931
144MP0003566_abnormal_cell_adhesion0.80365975
145MP0003953_abnormal_hormone_level0.79866049
146MP0002928_abnormal_bile_duct0.78928148
147MP0000759_abnormal_skeletal_muscle0.78198969
148MP0002254_reproductive_system_inflammat0.76574386
149MP0008789_abnormal_olfactory_epithelium0.76343389
150MP0005666_abnormal_adipose_tissue0.76039191
151MP0002938_white_spotting0.75012775
152MP0000428_abnormal_craniofacial_morphol0.74043072
153MP0001485_abnormal_pinna_reflex0.73093461
154MP0000049_abnormal_middle_ear0.72934055
155MP0002396_abnormal_hematopoietic_system0.71522535
156MP0005310_abnormal_salivary_gland0.71133921
157MP0002896_abnormal_bone_mineralization0.70267982
158MP0005636_abnormal_mineral_homeostasis0.70078823
159MP0001348_abnormal_lacrimal_gland0.69271750
160MP0009703_decreased_birth_body0.69162678
161MP0005645_abnormal_hypothalamus_physiol0.68031080
162MP0003121_genomic_imprinting0.68012072
163MP0003786_premature_aging0.66990225
164MP0000747_muscle_weakness0.65744433
165MP0005646_abnormal_pituitary_gland0.65437982
166MP0002177_abnormal_outer_ear0.65302771
167MP0002084_abnormal_developmental_patter0.65046266
168MP0004270_analgesia0.64828021
169MP0001731_abnormal_postnatal_growth0.63845814
170MP0001661_extended_life_span0.61586101
171MP0003634_abnormal_glial_cell0.61465578
172MP0005384_cellular_phenotype0.61267055
173MP0001727_abnormal_embryo_implantation0.60798354
174MP0001502_abnormal_circadian_rhythm0.60398084
175MP0001765_abnormal_ion_homeostasis0.59926357
176MP0000703_abnormal_thymus_morphology0.58978934
177MP0002160_abnormal_reproductive_system0.57104406
178MP0001905_abnormal_dopamine_level0.56530341
179MP0004147_increased_porphyrin_level0.56502608
180MP0000465_gastrointestinal_hemorrhage0.56488213

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.98742705
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.64516739
3Hypoglycemic seizures (HP:0002173)4.36710395
4Type I transferrin isoform profile (HP:0003642)4.09995946
5Symptomatic seizures (HP:0011145)4.08523484
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.93701307
7Abnormal protein N-linked glycosylation (HP:0012347)3.93701307
8Abnormal protein glycosylation (HP:0012346)3.93701307
9Abnormal glycosylation (HP:0012345)3.93701307
10Abnormality of liposaccharide metabolism (HP:0010968)3.92608039
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.92608039
12Abnormality of glycolipid metabolism (HP:0010969)3.92608039
13Hypoglycemic coma (HP:0001325)3.88586536
14Cerebral hypomyelination (HP:0006808)3.68142704
15Large for gestational age (HP:0001520)3.66278041
16Generalized aminoaciduria (HP:0002909)3.52288846
17Abnormality of the pancreatic islet cells (HP:0006476)3.42029168
18Abnormality of endocrine pancreas physiology (HP:0012093)3.42029168
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39917998
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39917998
21Late onset (HP:0003584)3.32317098
22Increased cerebral lipofuscin (HP:0011813)3.14981933
23Aplastic anemia (HP:0001915)3.14487488
24Hepatic necrosis (HP:0002605)3.12376512
25Vertebral compression fractures (HP:0002953)2.94625946
26Progressive neurologic deterioration (HP:0002344)2.91872874
27Abnormal pancreas size (HP:0012094)2.91333139
28Eczematoid dermatitis (HP:0000976)2.90419748
29Achilles tendon contracture (HP:0001771)2.85518389
30Progressive muscle weakness (HP:0003323)2.84511786
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.83215613
32Hepatocellular necrosis (HP:0001404)2.82069187
33Abnormality of macrophages (HP:0004311)2.81168531
34Acute necrotizing encephalopathy (HP:0006965)2.79265134
35Mediastinal lymphadenopathy (HP:0100721)2.78828311
36Abnormal mitochondria in muscle tissue (HP:0008316)2.76847086
37Axonal loss (HP:0003447)2.76031873
38Hepatosplenomegaly (HP:0001433)2.75499058
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.74440763
40Loss of speech (HP:0002371)2.71710020
41Petechiae (HP:0000967)2.70089572
42Pancreatic islet-cell hyperplasia (HP:0004510)2.69979543
43Dysostosis multiplex (HP:0000943)2.69595549
44Abnormality of the anterior horn cell (HP:0006802)2.69535338
45Degeneration of anterior horn cells (HP:0002398)2.69535338
46Elevated erythrocyte sedimentation rate (HP:0003565)2.66729931
4711 pairs of ribs (HP:0000878)2.66580945
48Upper motor neuron abnormality (HP:0002127)2.66425619
49Hyperparathyroidism (HP:0000843)2.62763469
50Decreased circulating renin level (HP:0003351)2.61992626
51Recurrent abscess formation (HP:0002722)2.61196942
52Prolonged neonatal jaundice (HP:0006579)2.53491252
53Chronic obstructive pulmonary disease (HP:0006510)2.52950335
54Obstructive lung disease (HP:0006536)2.52950335
55Urinary glycosaminoglycan excretion (HP:0003541)2.52487235
56Mucopolysacchariduria (HP:0008155)2.52487235
57Ketoacidosis (HP:0001993)2.52043033
58Cellulitis (HP:0100658)2.51588580
59Mitochondrial inheritance (HP:0001427)2.51373990
60Abnormal gallbladder physiology (HP:0012438)2.51012391
61Cholecystitis (HP:0001082)2.51012391
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.50840737
63Abnormality of the Achilles tendon (HP:0005109)2.50178521
64Microvesicular hepatic steatosis (HP:0001414)2.50169939
65Vacuolated lymphocytes (HP:0001922)2.49559461
66Prominent metopic ridge (HP:0005487)2.48485903
67Distal lower limb muscle weakness (HP:0009053)2.47797492
68Myositis (HP:0100614)2.46378291
69Increased serum ferritin (HP:0003281)2.45992003
70Hypertensive crisis (HP:0100735)2.44723487
71Microretrognathia (HP:0000308)2.44107062
72Distal lower limb amyotrophy (HP:0008944)2.43165251
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39160008
74Recurrent bacterial skin infections (HP:0005406)2.38268080
75Abnormal number of erythroid precursors (HP:0012131)2.38181102
76Increased muscle lipid content (HP:0009058)2.36364314
77Purpura (HP:0000979)2.35818064
78Increased connective tissue (HP:0009025)2.29697043
79Insulin resistance (HP:0000855)2.27502881
80Insulin-resistant diabetes mellitus (HP:0000831)2.27302784
81Increased intramyocellular lipid droplets (HP:0012240)2.26573504
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25172487
83Difficulty climbing stairs (HP:0003551)2.24573662
84Colitis (HP:0002583)2.23261915
85Missing ribs (HP:0000921)2.22858934
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21748801
87Abnormality of polysaccharide metabolism (HP:0011012)2.21748801
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21748801
89Abnormality of cells of the erythroid lineage (HP:0012130)2.20854739
90Systemic lupus erythematosus (HP:0002725)2.20772620
91Pheochromocytoma (HP:0002666)2.16751977
92Neuroendocrine neoplasm (HP:0100634)2.16475788
93Acute encephalopathy (HP:0006846)2.16008593
94Myopathic facies (HP:0002058)2.15383008
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.14177052
96Rough bone trabeculation (HP:0100670)2.13000575
97Menstrual irregularities (HP:0000858)2.12583148
98Postnatal microcephaly (HP:0005484)2.12152955
99Bulbar palsy (HP:0001283)2.12016655
100Cortical visual impairment (HP:0100704)2.11462285
101Reduced antithrombin III activity (HP:0001976)2.10979341
102Distal upper limb amyotrophy (HP:0007149)2.10688955
103Upper limb amyotrophy (HP:0009129)2.10688955
104CNS hypomyelination (HP:0003429)2.09789789
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09295335
106Increased IgE level (HP:0003212)2.07456617
107Short clavicles (HP:0000894)2.06727110
108Increased IgM level (HP:0003496)2.05861613
109Orchitis (HP:0100796)2.04291690
110Emotional lability (HP:0000712)2.03872715
111Aplasia/Hypoplasia of the clavicles (HP:0006710)2.02548050
112Unilateral renal agenesis (HP:0000122)2.02534636
113Amyloidosis (HP:0011034)2.02133197
114Hypoplastic pelvis (HP:0008839)2.01509247
115Split foot (HP:0001839)1.99596443
116Broad distal phalanx of finger (HP:0009836)1.98982242
117Slender long bone (HP:0003100)1.98576276
118Type II lissencephaly (HP:0007260)1.97558217
119Thoracic kyphosis (HP:0002942)1.97302252
120Increased CSF lactate (HP:0002490)1.97133941
121Primary adrenal insufficiency (HP:0008207)1.96846190
122Aplasia/hypoplasia of the uterus (HP:0008684)1.95892288
123Abnormality of the distal phalanges of the toes (HP:0010182)1.95117239
124Anteriorly placed anus (HP:0001545)1.94720328
125Abnormality of the metopic suture (HP:0005556)1.93701485
126Recurrent viral infections (HP:0004429)1.93519592
127Dysautonomia (HP:0002459)1.92344830
128Recurrent fungal infections (HP:0002841)1.92004509
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91849383
130Rhabdomyolysis (HP:0003201)1.91725994
131Meningitis (HP:0001287)1.90540350
132Gastrointestinal inflammation (HP:0004386)1.90389047
133Testicular atrophy (HP:0000029)1.89726474
134CNS demyelination (HP:0007305)1.88555708
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84433438
136Urticaria (HP:0001025)1.84433019
137Agammaglobulinemia (HP:0004432)1.84235899
138Interstitial pulmonary disease (HP:0006530)1.84084576
139Secondary amenorrhea (HP:0000869)1.83777490
140J-shaped sella turcica (HP:0002680)1.83736807
141Severe visual impairment (HP:0001141)1.83696858
142Hypokalemia (HP:0002900)1.83096896
143Stomatitis (HP:0010280)1.82726576
144Birth length less than 3rd percentile (HP:0003561)1.82378776
145Limb hypertonia (HP:0002509)1.81122016
146Gastrointestinal dysmotility (HP:0002579)1.80649995
147Generalized amyotrophy (HP:0003700)1.80291383
148Hypertriglyceridemia (HP:0002155)1.77950089
149Neuronal loss in central nervous system (HP:0002529)1.77160784
150Progressive macrocephaly (HP:0004481)1.76812471
151Increased serum lactate (HP:0002151)1.76547044
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76302677
153Pustule (HP:0200039)1.76167142
154Poor head control (HP:0002421)1.76008128
155Abnormal neuron morphology (HP:0012757)1.75428693
156Abnormality of the motor neurons (HP:0002450)1.75428693
157Thoracolumbar scoliosis (HP:0002944)1.74179331
158Long palpebral fissure (HP:0000637)1.74152116
159Spastic paraparesis (HP:0002313)1.74113170
160Gastrointestinal stroma tumor (HP:0100723)1.73065343
161Ragged-red muscle fibers (HP:0003200)1.72963865
162Hyperphosphaturia (HP:0003109)1.72832924
163Lactic acidosis (HP:0003128)1.72492065
164Abnormality of the intrinsic pathway (HP:0010989)1.72204038
165Peripheral hypomyelination (HP:0007182)1.71632517
166Entropion (HP:0000621)1.70360802
167Maternal diabetes (HP:0009800)1.69914353
168Exocrine pancreatic insufficiency (HP:0001738)1.69891601
169Trismus (HP:0000211)1.69832789
170Hypergammaglobulinemia (HP:0010702)1.69753072
171Abnormal trabecular bone morphology (HP:0100671)1.69738740
172Recurrent skin infections (HP:0001581)1.69404208
173Inflammation of the large intestine (HP:0002037)1.69343395
174Chronic bronchitis (HP:0004469)1.69214190
175Osteomalacia (HP:0002749)1.69178272
176Hyperglycemia (HP:0003074)1.68675555
177Abnormality of iron homeostasis (HP:0011031)1.68430897
178Neoplasm of the heart (HP:0100544)1.67762729
179Broad face (HP:0000283)1.67363330
180Hyperactive renin-angiotensin system (HP:0000841)1.67166051
181Fasciculations (HP:0002380)1.66964943
182Intestinal atresia (HP:0011100)1.66310801
183Irregular vertebral endplates (HP:0003301)1.65747514
184Polygenic inheritance (HP:0010982)1.65392395
185Unsteady gait (HP:0002317)1.64919975
186Poor suck (HP:0002033)1.64002672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.80145916
2PASK5.57994817
3MAPK154.36111607
4STK163.00305966
5IRAK32.95299827
6BUB12.56748527
7FLT32.34340044
8PRPF4B2.30481393
9BCKDK2.25347349
10TAOK22.22058018
11MAP2K32.21285885
12ERN12.11059211
13TBK12.04796200
14EIF2AK32.03607581
15HIPK21.94233723
16SMG11.92300112
17TRIB31.92133264
18SCYL21.88531555
19TESK21.88051813
20PRKD31.86645738
21UHMK11.71985085
22WEE11.69850620
23VRK11.67368318
24NME21.61352531
25DYRK31.58664952
26VRK21.57150998
27IRAK11.57142929
28CDK191.56021068
29LIMK11.54898350
30NTRK11.49335880
31TYK21.47406173
32ABL21.47380493
33TNIK1.40897864
34MAP2K21.40584696
35CCNB11.38681836
36TAOK11.35336395
37SIK11.35184529
38BRSK21.34939816
39MAP3K31.34793747
40BRSK11.33670410
41BRAF1.33460717
42SRPK11.24402685
43TESK11.23301079
44DYRK1B1.21950020
45BCR1.21058833
46CDC71.20604815
47MET1.18657815
48TTN1.16180973
49PIM21.15964197
50AURKA1.05836384
51KDR1.01010632
52IKBKB1.00247783
53TLK11.00166458
54BLK0.96180627
55MAP3K140.95718410
56GRK60.90460577
57PRKCI0.85731155
58MAP3K100.85552087
59EPHA20.85548903
60IKBKE0.83289653
61SIK20.82303355
62DAPK10.81177646
63FES0.79332040
64MOS0.79036644
65WNK40.78595358
66BMX0.78026600
67BTK0.77824804
68TNK20.77494503
69DYRK20.76291089
70MKNK10.76200127
71DAPK30.74778839
72MAP3K130.73719806
73CSF1R0.71682158
74MAP3K10.70905722
75JAK30.70697660
76CDK70.70159554
77TXK0.69336632
78ARAF0.67718202
79TSSK60.67357112
80CSK0.67260323
81SIK30.66555375
82PRKD20.66118445
83ICK0.62027826
84PTK20.61774186
85MAP3K20.60835084
86MAPK110.60768987
87RPS6KA50.58172581
88EPHA30.57687754
89LMTK20.57571642
90MATK0.56468335
91STK100.56459396
92MAP3K110.56181840
93MAP2K60.55902837
94AURKB0.55795984
95NEK20.55234031
96CHEK20.54947852
97CSNK1G30.54805398
98RIPK10.53993390
99ATR0.53538829
100IRAK20.53231637
101CDK140.52272628
102CDK40.52175425
103NME10.49049020
104MAP3K50.48462669
105RPS6KL10.48004601
106RPS6KC10.48004601
107PLK10.47856997
108ILK0.46734746
109ZAP700.46315892
110HCK0.46285687
111OXSR10.45005640
112MAP4K10.44396751
113CDC42BPA0.42976192
114RPS6KA20.42792151
115MAP3K60.42731536
116PDGFRA0.42702886
117RIPK40.42522927
118RAF10.42194944
119KIT0.41795939
120ACVR1B0.40757370
121PIM10.40518644
122ITK0.38814274
123IRAK40.38806189
124PAK10.38771398
125MARK20.38745903
126AKT20.38539421
127CDK11A0.38098792
128CDK180.37414779
129LYN0.37401185
130PKN20.36966072
131TIE10.36825246
132MAPKAPK20.36823798
133CDK150.35590869
134DDR20.35471196
135MAPK120.35125732
136PAK30.34626920
137MAP3K80.34401186
138PDPK10.34319926
139STK390.34086788
140CSNK2A20.33423521
141EIF2AK10.33363636
142MAPKAPK30.31285553
143PAK40.31168951
144CSNK1A1L0.30041357
145MAPK90.28726043
146EPHB10.27930612
147EPHB20.27695606
148RPS6KA40.26714182
149CSNK2A10.26367450
150CHEK10.26278274
151TEC0.24766387
152LRRK20.22569808
153PTK60.22383545
154FGFR40.22360622
155CDK20.21420663

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.78377108
2Protein export_Homo sapiens_hsa030605.68667506
3DNA replication_Homo sapiens_hsa030303.56842081
4Proteasome_Homo sapiens_hsa030502.77724348
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76986148
6Mismatch repair_Homo sapiens_hsa034302.71946846
7Spliceosome_Homo sapiens_hsa030402.32743352
8N-Glycan biosynthesis_Homo sapiens_hsa005102.27992279
9Ribosome_Homo sapiens_hsa030102.26383994
10RNA polymerase_Homo sapiens_hsa030202.23161478
11Base excision repair_Homo sapiens_hsa034102.21280612
12Homologous recombination_Homo sapiens_hsa034402.20845844
13Pyrimidine metabolism_Homo sapiens_hsa002402.15384066
14Nucleotide excision repair_Homo sapiens_hsa034201.99727182
15Folate biosynthesis_Homo sapiens_hsa007901.98141757
16Sulfur metabolism_Homo sapiens_hsa009201.96823697
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85520049
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84871032
19Vibrio cholerae infection_Homo sapiens_hsa051101.76577649
20Primary immunodeficiency_Homo sapiens_hsa053401.64487977
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63710576
22Osteoclast differentiation_Homo sapiens_hsa043801.63240950
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.57875478
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54633699
25Oxidative phosphorylation_Homo sapiens_hsa001901.53952306
26Leishmaniasis_Homo sapiens_hsa051401.53275336
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52297567
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51484840
29Biosynthesis of amino acids_Homo sapiens_hsa012301.49414886
30Cell cycle_Homo sapiens_hsa041101.48133820
31Selenocompound metabolism_Homo sapiens_hsa004501.45197826
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40719994
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.40563388
34RNA transport_Homo sapiens_hsa030131.40240645
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36529601
36Allograft rejection_Homo sapiens_hsa053301.36523328
37Salmonella infection_Homo sapiens_hsa051321.36044011
38Parkinsons disease_Homo sapiens_hsa050121.35574942
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.34014578
40Sulfur relay system_Homo sapiens_hsa041221.28039073
41Basal transcription factors_Homo sapiens_hsa030221.25852883
42Herpes simplex infection_Homo sapiens_hsa051681.24407286
43Tuberculosis_Homo sapiens_hsa051521.24118150
44Graft-versus-host disease_Homo sapiens_hsa053321.22212230
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20760841
46Apoptosis_Homo sapiens_hsa042101.18917835
47Purine metabolism_Homo sapiens_hsa002301.16984559
48Viral myocarditis_Homo sapiens_hsa054161.15276709
49Non-homologous end-joining_Homo sapiens_hsa034501.14296794
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13718360
51Regulation of autophagy_Homo sapiens_hsa041401.13231893
52Rheumatoid arthritis_Homo sapiens_hsa053231.13112087
53Malaria_Homo sapiens_hsa051441.12785015
54Insulin secretion_Homo sapiens_hsa049111.11146445
55Other glycan degradation_Homo sapiens_hsa005111.10570192
56Autoimmune thyroid disease_Homo sapiens_hsa053201.10433261
57TNF signaling pathway_Homo sapiens_hsa046681.09084594
58One carbon pool by folate_Homo sapiens_hsa006701.06871504
59B cell receptor signaling pathway_Homo sapiens_hsa046621.01902550
60Pertussis_Homo sapiens_hsa051331.00534999
61Influenza A_Homo sapiens_hsa051641.00302713
62Toxoplasmosis_Homo sapiens_hsa051450.99321342
63Fanconi anemia pathway_Homo sapiens_hsa034600.97453029
64Lysosome_Homo sapiens_hsa041420.96205835
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93856551
66Huntingtons disease_Homo sapiens_hsa050160.93418833
67Alcoholism_Homo sapiens_hsa050340.93217465
68RNA degradation_Homo sapiens_hsa030180.92417444
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91850317
70Hepatitis B_Homo sapiens_hsa051610.90245798
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.90100551
72Carbon metabolism_Homo sapiens_hsa012000.89945599
73Alzheimers disease_Homo sapiens_hsa050100.87889884
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84568712
75Hepatitis C_Homo sapiens_hsa051600.83934472
76Asthma_Homo sapiens_hsa053100.82497527
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81424721
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78978447
79Staphylococcus aureus infection_Homo sapiens_hsa051500.78067267
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76915887
81Measles_Homo sapiens_hsa051620.75910131
82VEGF signaling pathway_Homo sapiens_hsa043700.75366445
83Notch signaling pathway_Homo sapiens_hsa043300.75338276
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75159542
85Hematopoietic cell lineage_Homo sapiens_hsa046400.73445870
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73246964
87mRNA surveillance pathway_Homo sapiens_hsa030150.73085609
88p53 signaling pathway_Homo sapiens_hsa041150.71870372
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70869628
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70083057
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69792219
92Fatty acid elongation_Homo sapiens_hsa000620.68749565
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68414722
94Epstein-Barr virus infection_Homo sapiens_hsa051690.67565394
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.65392416
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63961137
97Phenylalanine metabolism_Homo sapiens_hsa003600.63057469
98Bladder cancer_Homo sapiens_hsa052190.62772398
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.61259214
100Cocaine addiction_Homo sapiens_hsa050300.59759440
101Type I diabetes mellitus_Homo sapiens_hsa049400.58125498
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56071128
103Pancreatic cancer_Homo sapiens_hsa052120.55280045
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55004285
105Viral carcinogenesis_Homo sapiens_hsa052030.54891912
106Steroid biosynthesis_Homo sapiens_hsa001000.54372041
107Galactose metabolism_Homo sapiens_hsa000520.54235071
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.53587554
109African trypanosomiasis_Homo sapiens_hsa051430.46321084
110Sphingolipid metabolism_Homo sapiens_hsa006000.46010823
111Non-small cell lung cancer_Homo sapiens_hsa052230.45997398
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45882479
113Metabolic pathways_Homo sapiens_hsa011000.45533603
114Systemic lupus erythematosus_Homo sapiens_hsa053220.45009399
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41812391
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40700057
117Type II diabetes mellitus_Homo sapiens_hsa049300.39581096
118Antigen processing and presentation_Homo sapiens_hsa046120.38613070
119Thyroid cancer_Homo sapiens_hsa052160.38184792
120Butanoate metabolism_Homo sapiens_hsa006500.37203712
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36926142
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34546654
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31764933
124Linoleic acid metabolism_Homo sapiens_hsa005910.31595417
125Fructose and mannose metabolism_Homo sapiens_hsa000510.29660932
126Pentose phosphate pathway_Homo sapiens_hsa000300.28187782
127Arginine and proline metabolism_Homo sapiens_hsa003300.28160617
128Oocyte meiosis_Homo sapiens_hsa041140.27256639
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.25324661
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25258614
131Glutathione metabolism_Homo sapiens_hsa004800.21512012
132Pancreatic secretion_Homo sapiens_hsa049720.21458764
133HTLV-I infection_Homo sapiens_hsa051660.21420838
134Prion diseases_Homo sapiens_hsa050200.20818521
135Shigellosis_Homo sapiens_hsa051310.18591694
136Prolactin signaling pathway_Homo sapiens_hsa049170.18320887
137Arachidonic acid metabolism_Homo sapiens_hsa005900.17953710
138Endocytosis_Homo sapiens_hsa041440.17871886
139Legionellosis_Homo sapiens_hsa051340.17572661
140Serotonergic synapse_Homo sapiens_hsa047260.15509402
141Hedgehog signaling pathway_Homo sapiens_hsa043400.14911163
142Chronic myeloid leukemia_Homo sapiens_hsa052200.12767459
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12632772
144Circadian rhythm_Homo sapiens_hsa047100.12588685
145Collecting duct acid secretion_Homo sapiens_hsa049660.10835983
146Prostate cancer_Homo sapiens_hsa052150.10541801
147Acute myeloid leukemia_Homo sapiens_hsa052210.10096534
148Phagosome_Homo sapiens_hsa041450.09711542
149Taste transduction_Homo sapiens_hsa047420.09398844
150Ether lipid metabolism_Homo sapiens_hsa005650.08930907

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