ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	embryonic camera-type eye development (GO:0031076)	9.44865990
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	8.94430878
3	regulation of cellular respiration (GO:0043457)	8.77191672
4	tongue development (GO:0043586)	8.63492931
5	neuron fate determination (GO:0048664)	8.28261598
6	positive regulation of protein depolymerization (GO:1901881)	8.06906622
7	negative regulation of granulocyte differentiation (GO:0030853)	7.32713950
8	synaptic transmission, cholinergic (GO:0007271)	7.07391236
9	positive regulation of action potential (GO:0045760)	6.20274170
10	positive regulation of neural precursor cell proliferation (GO:2000179)	5.81610276
11	positive regulation of protein complex disassembly (GO:0043243)	5.30693285
12	detection of mechanical stimulus involved in sensory perception (GO:0050974)	5.24296160
13	transmission of nerve impulse (GO:0019226)	4.95584673
14	white fat cell differentiation (GO:0050872)	4.88846139
15	glucocorticoid receptor signaling pathway (GO:0042921)	4.85189225
16	primitive streak formation (GO:0090009)	4.59234750
17	short-term memory (GO:0007614)	4.46299190
18	positive regulation of catecholamine secretion (GO:0033605)	4.25772609
19	negative regulation of appetite (GO:0032099)	4.19723425
20	negative regulation of response to food (GO:0032096)	4.19723425
21	maturation of SSU-rRNA (GO:0030490)	4.19071396
22	positive regulation of gastrulation (GO:2000543)	4.13587870
23	regulation of oxidative phosphorylation (GO:0002082)	4.06148009
24	retina layer formation (GO:0010842)	4.02569659
25	behavioral response to nicotine (GO:0035095)	3.94300863
26	negative regulation of amino acid transport (GO:0051956)	3.93620506
27	regulation of relaxation of muscle (GO:1901077)	3.74205308
28	corticosteroid receptor signaling pathway (GO:0031958)	3.73837232
29	myofibril assembly (GO:0030239)	3.73301976
30	ribosomal small subunit biogenesis (GO:0042274)	3.72952868
31	positive regulation of protein export from nucleus (GO:0046827)	3.71157522
32	multicellular organism reproduction (GO:0032504)	3.66866297
33	cerebellar granule cell differentiation (GO:0021707)	3.65888011
34	DNA strand renaturation (GO:0000733)	3.62469514
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59875322
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59875322
37	NADH dehydrogenase complex assembly (GO:0010257)	3.59875322
38	negative regulation of activin receptor signaling pathway (GO:0032926)	3.53709938
39	nerve growth factor signaling pathway (GO:0038180)	3.50319012
40	collecting duct development (GO:0072044)	3.49609953
41	peptidyl-cysteine modification (GO:0018198)	3.47676752
42	detection of mechanical stimulus (GO:0050982)	3.44602977
43	cerebral cortex radially oriented cell migration (GO:0021799)	3.41507924
44	glomerular visceral epithelial cell development (GO:0072015)	3.40340760
45	cytokine production involved in immune response (GO:0002367)	3.39820030
46	regulation of glutamate secretion (GO:0014048)	3.35501770
47	protein insertion into membrane (GO:0051205)	3.35266901
48	regulation of action potential (GO:0098900)	3.33662407
49	resolution of meiotic recombination intermediates (GO:0000712)	3.28834024
50	positive regulation of neuroblast proliferation (GO:0002052)	3.26937292
51	regulation of neural precursor cell proliferation (GO:2000177)	3.25894326
52	muscle cell cellular homeostasis (GO:0046716)	3.24153510
53	postsynaptic membrane organization (GO:0001941)	3.18075058
54	dopaminergic neuron differentiation (GO:0071542)	3.14356787
55	cardiac myofibril assembly (GO:0055003)	3.14101765
56	viral transcription (GO:0019083)	3.12441626
57	inner ear morphogenesis (GO:0042472)	3.07481470
58	sarcomere organization (GO:0045214)	3.04367417
59	glomerular epithelial cell development (GO:0072310)	3.01537341
60	detection of calcium ion (GO:0005513)	3.01417284
61	somite rostral/caudal axis specification (GO:0032525)	3.00064943
62	sensory perception of smell (GO:0007608)	2.99821255
63	protein localization to cilium (GO:0061512)	2.96887160
64	translational termination (GO:0006415)	2.96505584
65	regulation of granulocyte differentiation (GO:0030852)	2.94584802
66	male meiosis (GO:0007140)	2.92556475
67	regulation of collateral sprouting (GO:0048670)	2.90978907
68	male meiosis I (GO:0007141)	2.87304060
69	response to muscle activity (GO:0014850)	2.85737045
70	platelet formation (GO:0030220)	2.84431013
71	olfactory bulb development (GO:0021772)	2.84069053
72	adult heart development (GO:0007512)	2.82456827
73	plasma membrane repair (GO:0001778)	2.81581267
74	regulation of endothelial cell chemotaxis (GO:2001026)	2.80171223
75	reproduction (GO:0000003)	2.77863394
76	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.76181296
77	regulation of response to food (GO:0032095)	2.76135368
78	cellular response to nerve growth factor stimulus (GO:1990090)	2.75236818
79	response to nerve growth factor (GO:1990089)	2.75236818
80	negative regulation of protein binding (GO:0032091)	2.72692794
81	ovulation cycle (GO:0042698)	2.69324629
82	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.68909653
83	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.68728079
84	midbrain development (GO:0030901)	2.67795514
85	relaxation of smooth muscle (GO:0044557)	2.66919359
86	proteasome assembly (GO:0043248)	2.65204768
87	glyoxylate metabolic process (GO:0046487)	2.63974081
88	cell proliferation in forebrain (GO:0021846)	2.63137261
89	meiosis I (GO:0007127)	2.62476270
90	DNA integration (GO:0015074)	2.61559054
91	glycerophospholipid catabolic process (GO:0046475)	2.61213893
92	fat-soluble vitamin biosynthetic process (GO:0042362)	2.60640724
93	lung epithelium development (GO:0060428)	2.59362284
94	calcium ion transmembrane transport (GO:0070588)	2.56611061
95	notochord development (GO:0030903)	2.55657781
96	cellular ketone body metabolic process (GO:0046950)	2.54980981
97	sensory organ development (GO:0007423)	2.53573757
98	neurogenesis (GO:0022008)	2.52625749
99	mitochondrion degradation (GO:0000422)	2.51903879
100	adaptation of signaling pathway (GO:0023058)	10.6401206

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.07864270
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.76446495
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.99269901
4	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.84171827
5	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.56459964
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.54843300
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31858273
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.06408658
9	EZH2_22144423_ChIP-Seq_EOC_Human	14.5636455
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.85102481
11	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.79618907
12	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.79618907
13	CTCF_27219007_Chip-Seq_Bcells_Human	1.70642614
14	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.70152521
15	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.59311481
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58051061
17	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.57998767
18	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.50765074
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47543947
20	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.46719037
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.45675156
22	DROSHA_22980978_ChIP-Seq_HELA_Human	1.38264590
23	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37797673
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35225125
25	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.32982787
26	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.32551933
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30849395
28	SA1_27219007_Chip-Seq_Bcells_Human	1.27139850
29	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.25098622
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21520715
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21520715
32	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.14884381
33	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.14437637
34	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.14437637
35	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.14437637
36	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.13524383
37	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.12940238
38	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11671668
39	ERA_21632823_ChIP-Seq_H3396_Human	1.10324291
40	VDR_22108803_ChIP-Seq_LS180_Human	1.09853968
41	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.07962323
42	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07150179
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05125718
44	ZNF274_21170338_ChIP-Seq_K562_Hela	1.04740288
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04497521
46	NFYA_21822215_ChIP-Seq_K562_Human	1.01290513
47	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.98141437
48	PHF8_20622853_ChIP-Seq_HELA_Human	0.97344774
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96158162
50	NFYB_21822215_ChIP-Seq_K562_Human	0.94025650
51	JUN_21703547_ChIP-Seq_K562_Human	0.92847551
52	SMAD4_21799915_ChIP-Seq_A2780_Human	0.91265129
53	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.90569967
54	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.89347067
55	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89328149
56	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.88822767
57	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.87635277
58	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.86561856
59	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85668330
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.85422689
61	GBX2_23144817_ChIP-Seq_PC3_Human	0.85356503
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.85236761
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.83226857
64	GF1_26923725_Chip-Seq_HPCs_Mouse	0.82925229
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.82697535
66	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.82067332
67	PHF8_20622854_ChIP-Seq_HELA_Human	0.81999527
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81288206
69	FUS_26573619_Chip-Seq_HEK293_Human	0.81186903
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.80776178
71	ER_23166858_ChIP-Seq_MCF-7_Human	0.80691709
72	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.80580101
73	TBL1_22424771_ChIP-Seq_293T_Human	0.79407520
74	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.79278585
75	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.76623332
76	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.75961675
77	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.75424462
78	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.75117308
79	SMC4_20622854_ChIP-Seq_HELA_Human	0.74750929
80	TP63_22573176_ChIP-Seq_HFKS_Human	0.73648284
81	CEBPB_22108803_ChIP-Seq_LS180_Human	0.72552359
82	ETV1_20927104_ChIP-Seq_GIST48_Human	0.72459416
83	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.72129871
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.71576588
85	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.70978604
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.70649981
87	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.70606973
88	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.70278181
89	KDM2B_26808549_Chip-Seq_DND41_Human	0.69642809
90	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.69607147
91	SCL_19346495_ChIP-Seq_HPC-7_Human	0.68156605
92	RAC3_21632823_ChIP-Seq_H3396_Human	0.67681036
93	CBP_21632823_ChIP-Seq_H3396_Human	0.67534519
94	LXR_22292898_ChIP-Seq_THP-1_Human	0.67049923
95	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.66372111
96	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.65343087
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.65322703
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.64815936
99	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.64802666
100	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.64626358

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.20318376
2	MP0006292_abnormal_olfactory_placode	5.56186418
3	MP0003879_abnormal_hair_cell	5.31573384
4	MP0002234_abnormal_pharynx_morphology	4.57327086
5	MP0008789_abnormal_olfactory_epithelium	4.39527964
6	MP0004145_abnormal_muscle_electrophysio	3.88188160
7	MP0005499_abnormal_olfactory_system	3.78909862
8	MP0005394_taste/olfaction_phenotype	3.78909862
9	MP0009278_abnormal_bone_marrow	3.17759838
10	MP0010030_abnormal_orbit_morphology	3.14711043
11	MP0003950_abnormal_plasma_membrane	3.11337994
12	MP0003890_abnormal_embryonic-extraembry	2.54815660
13	MP0004264_abnormal_extraembryonic_tissu	2.17118491
14	MP0004510_myositis	2.05842756
15	MP0005423_abnormal_somatic_nervous	1.69235422
16	MP0003868_abnormal_feces_composition	1.65930938
17	MP0002184_abnormal_innervation	1.64960281
18	MP0000749_muscle_degeneration	1.62471542
19	MP0005409_darkened_coat_color	1.59743713
20	MP0002876_abnormal_thyroid_physiology	1.59113926
21	MP0005058_abnormal_lysosome_morphology	1.57989270
22	MP0005410_abnormal_fertilization	1.57303542
23	MP0001324_abnormal_eye_pigmentation	1.53864249
24	MP0002736_abnormal_nociception_after	1.53694629
25	MP0003880_abnormal_central_pattern	1.52431712
26	MP0001293_anophthalmia	1.45578247
27	MP0003567_abnormal_fetal_cardiomyocyte	1.44583064
28	MP0004185_abnormal_adipocyte_glucose	1.44324628
29	MP0003806_abnormal_nucleotide_metabolis	1.41986920
30	MP0004130_abnormal_muscle_cell	1.39801765
31	MP0003755_abnormal_palate_morphology	1.39578633
32	MP0005551_abnormal_eye_electrophysiolog	1.39024487
33	MP0001545_abnormal_hematopoietic_system	1.37536360
34	MP0005397_hematopoietic_system_phenotyp	1.37536360
35	MP0002837_dystrophic_cardiac_calcinosis	1.35096078
36	MP0003646_muscle_fatigue	1.27095810
37	MP0001968_abnormal_touch/_nociception	1.24547839
38	MP0001919_abnormal_reproductive_system	1.22257596
39	MP0005646_abnormal_pituitary_gland	1.16706682
40	MP0002233_abnormal_nose_morphology	1.11705965
41	MP0002909_abnormal_adrenal_gland	1.10918093
42	MP0000762_abnormal_tongue_morphology	1.10870338
43	MP0004233_abnormal_muscle_weight	1.07921679
44	MP0000750_abnormal_muscle_regeneration	1.05218552
45	MP0005365_abnormal_bile_salt	1.01821463
46	MP0000534_abnormal_ureter_morphology	1.00513758
47	MP0003635_abnormal_synaptic_transmissio	0.99423612
48	MP0000026_abnormal_inner_ear	0.98796227
49	MP0000049_abnormal_middle_ear	0.98291902
50	MP0002733_abnormal_thermal_nociception	0.98138688
51	MP0005666_abnormal_adipose_tissue	0.95753610
52	MP0003283_abnormal_digestive_organ	0.95532196
53	MP0002249_abnormal_larynx_morphology	0.95115514
54	MP0001986_abnormal_taste_sensitivity	0.94970258
55	MP0000678_abnormal_parathyroid_gland	0.93751202
56	MP0002064_seizures	0.93695964
57	MP0005197_abnormal_uvea_morphology	0.93176626
58	MP0004147_increased_porphyrin_level	0.92812311
59	MP0002160_abnormal_reproductive_system	0.92217895
60	MP0005174_abnormal_tail_pigmentation	0.91380903
61	MP0009053_abnormal_anal_canal	0.91020159
62	MP0005248_abnormal_Harderian_gland	0.87984846
63	MP0008004_abnormal_stomach_pH	0.81619691
64	MP0001963_abnormal_hearing_physiology	0.80755567
65	MP0002106_abnormal_muscle_physiology	0.80542608
66	MP0001970_abnormal_pain_threshold	0.80007783
67	MP0002127_abnormal_cardiovascular_syste	0.75761128
68	MP0003011_delayed_dark_adaptation	0.75495988
69	MP0005167_abnormal_blood-brain_barrier	0.72708932
70	MP0003698_abnormal_male_reproductive	0.71912723
71	MP0009745_abnormal_behavioral_response	0.71492133
72	MP0004087_abnormal_muscle_fiber	0.70793665
73	MP0003942_abnormal_urinary_system	0.70007702
74	MP0008877_abnormal_DNA_methylation	0.67641585
75	MP0001299_abnormal_eye_distance/	0.66956711
76	MP0005195_abnormal_posterior_eye	0.66838407
77	MP0002752_abnormal_somatic_nervous	0.66047701
78	MP0000428_abnormal_craniofacial_morphol	0.65782805
79	MP0001881_abnormal_mammary_gland	0.65451982
80	MP0004036_abnormal_muscle_relaxation	0.64475085
81	MP0005330_cardiomyopathy	0.64147126
82	MP0000613_abnormal_salivary_gland	0.63600301
83	MP0005369_muscle_phenotype	0.62900939
84	MP0001905_abnormal_dopamine_level	0.62507440
85	MP0005389_reproductive_system_phenotype	0.60894742
86	MP0002272_abnormal_nervous_system	0.60174484
87	MP0004084_abnormal_cardiac_muscle	0.59067906
88	MP0008569_lethality_at_weaning	0.59012009
89	MP0000372_irregular_coat_pigmentation	0.58615485
90	MP0001188_hyperpigmentation	0.58110921
91	MP0002735_abnormal_chemical_nociception	0.57445636
92	MP0004215_abnormal_myocardial_fiber	0.57234122
93	MP0003866_abnormal_defecation	0.56627023
94	MP0002882_abnormal_neuron_morphology	0.55448975
95	MP0005670_abnormal_white_adipose	0.54486935
96	MP0002269_muscular_atrophy	0.54183227
97	MP0000759_abnormal_skeletal_muscle	0.53755511
98	MP0005391_vision/eye_phenotype	0.52332469
99	MP0003315_abnormal_perineum_morphology	0.52006083
100	MP0001486_abnormal_startle_reflex	0.51534125

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal atrophy (HP:0001105)	6.96264723
2	Annular pancreas (HP:0001734)	6.33669589
3	Septo-optic dysplasia (HP:0100842)	5.41560769
4	Abnormality of abdominal situs (HP:0011620)	5.12553875
5	Abdominal situs inversus (HP:0003363)	5.12553875
6	Abnormal ciliary motility (HP:0012262)	4.36231886
7	Large eyes (HP:0001090)	4.33980413
8	Absent septum pellucidum (HP:0001331)	3.80262820
9	Maternal diabetes (HP:0009800)	3.55215962
10	Chronic otitis media (HP:0000389)	3.51343385
11	Broad distal phalanx of finger (HP:0009836)	3.44865834
12	Male infertility (HP:0003251)	3.42484548
13	Papillary thyroid carcinoma (HP:0002895)	3.11066269
14	Abnormality of the septum pellucidum (HP:0007375)	3.07114324
15	Bony spicule pigmentary retinopathy (HP:0007737)	3.05180123
16	Lower limb asymmetry (HP:0100559)	3.04815069
17	Patent foramen ovale (HP:0001655)	2.99696813
18	Abnormal respiratory motile cilium physiology (HP:0012261)	2.96479121
19	Enlarged kidneys (HP:0000105)	2.90377973
20	Exercise-induced myalgia (HP:0003738)	2.88060271
21	Abnormal respiratory epithelium morphology (HP:0012253)	2.79370252
22	Abnormal respiratory motile cilium morphology (HP:0005938)	2.79370252
23	Eosinophilia (HP:0001880)	2.76562230
24	Muscle hypertrophy of the lower extremities (HP:0008968)	2.64612019
25	Anophthalmia (HP:0000528)	2.63595713
26	Spinal canal stenosis (HP:0003416)	2.62021811
27	Gonadotropin excess (HP:0000837)	2.61668726
28	Aplasia involving bones of the extremities (HP:0009825)	2.59110000
29	Aplasia involving bones of the upper limbs (HP:0009823)	2.59110000
30	Aplasia of the phalanges of the hand (HP:0009802)	2.59110000
31	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.50212185
32	Optic nerve hypoplasia (HP:0000609)	2.45988094
33	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.45633840
34	Atonic seizures (HP:0010819)	2.44635313
35	Pulmonic stenosis (HP:0001642)	2.43789169
36	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.41161541
37	Chronic hepatic failure (HP:0100626)	2.39613908
38	Abnormality of the pons (HP:0007361)	2.36552700
39	Granulocytopenia (HP:0001913)	2.36007103
40	Generalized myoclonic seizures (HP:0002123)	2.33612887
41	Microretrognathia (HP:0000308)	2.32845123
42	Chronic sinusitis (HP:0011109)	2.32740906
43	Agitation (HP:0000713)	2.30521503
44	Absent frontal sinuses (HP:0002688)	2.29988690
45	Neuroblastoma (HP:0003006)	2.29618716
46	Primitive neuroectodermal tumor (HP:0030065)	2.29618716
47	Neuroblastic tumors (HP:0004376)	2.29618716
48	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	2.29618716
49	Calf muscle hypertrophy (HP:0008981)	2.29581543
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.29513785
51	Muscle fiber inclusion bodies (HP:0100299)	2.27150002
52	Asplenia (HP:0001746)	2.25674562
53	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.25397529
54	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.23548791
55	Abnormality of cells of the erythroid lineage (HP:0012130)	2.23196169
56	Absent/shortened dynein arms (HP:0200106)	2.21642391
57	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21642391
58	Increased IgM level (HP:0003496)	2.15706757
59	Cellular immunodeficiency (HP:0005374)	2.15479727
60	Hypoplasia of the thymus (HP:0000778)	2.12600885
61	Abnormal number of erythroid precursors (HP:0012131)	2.11659758
62	Amblyopia (HP:0000646)	2.11396995
63	Oligodactyly (hands) (HP:0001180)	2.10550393
64	Aortic valve stenosis (HP:0001650)	2.09528596
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06283329
66	Mitral regurgitation (HP:0001653)	2.05983263
67	Abnormality of eosinophils (HP:0001879)	2.05773705
68	Bilateral microphthalmos (HP:0007633)	2.02329397
69	Impulsivity (HP:0100710)	2.01356524
70	Nasal polyposis (HP:0100582)	2.01233407
71	Abnormality of the frontal sinuses (HP:0002687)	1.99699914
72	Midline defect of the nose (HP:0004122)	1.94981147
73	Hypoproteinemia (HP:0003075)	1.93402778
74	Thin bony cortex (HP:0002753)	1.91198275
75	Hyporeflexia of lower limbs (HP:0002600)	1.89560975
76	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.88742490
77	Failure to thrive in infancy (HP:0001531)	1.86775718
78	EMG: myopathic abnormalities (HP:0003458)	1.86173259
79	Abnormality of the calf musculature (HP:0001430)	1.83788671
80	Focal motor seizures (HP:0011153)	1.83598323
81	Congenital glaucoma (HP:0001087)	1.83072344
82	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.82102132
83	Thyroid carcinoma (HP:0002890)	1.81663475
84	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.81407462
85	Absent epiphyses (HP:0010577)	1.81407462
86	Abnormality of magnesium homeostasis (HP:0004921)	1.78480345
87	Poor eye contact (HP:0000817)	1.78329738
88	Abnormality of the left ventricular outflow tract (HP:0011103)	1.77360935
89	Subaortic stenosis (HP:0001682)	1.77360935
90	Scapular winging (HP:0003691)	1.76054679
91	Clumsiness (HP:0002312)	1.75754742
92	Bundle branch block (HP:0011710)	1.74742929
93	Weak cry (HP:0001612)	1.74178212
94	Supernumerary spleens (HP:0009799)	1.73577218
95	Renal Fanconi syndrome (HP:0001994)	1.73084985
96	Morphological abnormality of the middle ear (HP:0008609)	1.70386676
97	Oligodactyly (HP:0012165)	1.69583457
98	Renal dysplasia (HP:0000110)	1.68717347
99	Abnormal eating behavior (HP:0100738)	1.66639272
100	Abnormal lung lobation (HP:0002101)	1.65484784

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMKK2	6.25486518
2	PINK1	5.09225055
3	WNK1	4.67978272
4	MARK3	3.95100029
5	MAPK13	3.52181566
6	CAMKK1	2.87518992
7	OBSCN	2.85814051
8	STK16	2.74644729
9	ACVR1B	2.66553310
10	TLK1	2.29998925
11	DMPK	1.98753269
12	CDK15	1.93225809
13	CDK14	1.84573200
14	CDK18	1.82926001
15	KSR1	1.81622777
16	CDK11A	1.81546209
17	PRKD3	1.53186792
18	MAP3K1	1.49206327
19	TYRO3	1.47685629
20	PRKCH	1.44410123
21	MAP3K10	1.37940638
22	CAMK1	1.29900183
23	PRKD2	1.23689502
24	SGK2	1.21530530
25	SGK494	1.17067105
26	SGK223	1.17067105
27	CAMK4	1.16908655
28	CDC7	1.16124043
29	BRAF	1.08660058
30	MAP2K3	1.06067764
31	MAP2K2	1.05039780
32	MAP2K6	0.98825373
33	CDK5	0.94002077
34	RPS6KA5	0.87593566
35	DYRK3	0.85809641
36	ADRBK2	0.83661584
37	MTOR	0.73729571
38	SGK3	0.71238350
39	WNK4	0.70458384
40	SIK2	0.69406451
41	LRRK2	0.68537867
42	TNK2	0.66315653
43	DYRK2	0.66251326
44	MAPK9	0.64945173
45	CAMK2G	0.63896791
46	PIM1	0.61945604
47	KDR	0.60978326
48	CAMK2A	0.57660940
49	PAK3	0.57311744
50	TAOK1	0.56391372
51	SIK1	0.56384340
52	PHKG2	0.55686174
53	PHKG1	0.55686174
54	PKN1	0.55482161
55	PLK4	0.52319727
56	RPS6KA4	0.50658349
57	ATR	0.46599479
58	HIPK2	0.46503156
59	PTK2B	0.46095646
60	MUSK	0.45853548
61	CSNK1G3	0.45355552
62	BMX	0.45199572
63	STK3	0.44285120
64	OXSR1	0.44233757
65	MAP3K8	0.43856672
66	GRK1	0.42825786
67	CSNK1G2	0.42152171
68	PRKACA	0.41084465
69	PDGFRA	0.40611843
70	KSR2	0.38728951
71	CAMK2B	0.36441176
72	PRKCI	0.36281828
73	PRKCE	0.35957547
74	CDK1	0.35704778
75	STK39	0.35563733
76	VRK1	0.33716571
77	PRKCZ	0.33417306
78	LATS2	0.32266660
79	GRK5	0.32176447
80	ATM	0.31916101
81	FGR	0.30761411
82	RPS6KA2	0.29471594
83	EPHB2	0.28579809
84	PRKD1	0.28525159
85	MAPK14	0.27791192
86	FRK	0.27603722
87	MAPK15	0.25977521
88	PBK	0.25857412
89	MINK1	0.25842748
90	CAMK2D	0.25674725
91	MAPK10	0.24870102
92	ALK	0.24455585
93	STK11	0.24214777
94	ROCK1	0.23772382
95	CAMK1D	0.23740053
96	PRKCG	0.23662342
97	CDK2	0.23291888
98	MOS	0.22362783
99	CSF1R	0.21919166
100	EPHA3	0.21722762

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.28901868
2	Regulation of autophagy_Homo sapiens_hsa04140	3.08218303
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.80882729
4	Protein export_Homo sapiens_hsa03060	2.45421513
5	Oxytocin signaling pathway_Homo sapiens_hsa04921	2.26303768
6	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	2.13247342
7	Thyroid cancer_Homo sapiens_hsa05216	2.09935699
8	Olfactory transduction_Homo sapiens_hsa04740	2.05763973
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.04270640
10	Long-term potentiation_Homo sapiens_hsa04720	1.98499994
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.80652088
12	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.74126879
13	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.73757052
14	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.73062771
15	Phototransduction_Homo sapiens_hsa04744	1.72639070
16	Gastric acid secretion_Homo sapiens_hsa04971	1.63891636
17	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.63192063
18	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.59072942
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.55852082
20	Gap junction_Homo sapiens_hsa04540	1.52931301
21	Calcium signaling pathway_Homo sapiens_hsa04020	1.51321517
22	Huntingtons disease_Homo sapiens_hsa05016	1.48368965
23	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.45306056
24	Folate biosynthesis_Homo sapiens_hsa00790	1.41647419
25	Long-term depression_Homo sapiens_hsa04730	1.39341069
26	Basal transcription factors_Homo sapiens_hsa03022	1.33936581
27	Amphetamine addiction_Homo sapiens_hsa05031	1.32922074
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.32873802
29	Galactose metabolism_Homo sapiens_hsa00052	1.29113071
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.27501693
31	Circadian entrainment_Homo sapiens_hsa04713	1.25097035
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21220581
33	Melanogenesis_Homo sapiens_hsa04916	1.19693752
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.19652433
35	Cholinergic synapse_Homo sapiens_hsa04725	1.17052524
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.15449554
37	Platelet activation_Homo sapiens_hsa04611	1.12261491
38	Parkinsons disease_Homo sapiens_hsa05012	1.10460084
39	Homologous recombination_Homo sapiens_hsa03440	1.08472813
40	GnRH signaling pathway_Homo sapiens_hsa04912	1.06624826
41	Glucagon signaling pathway_Homo sapiens_hsa04922	1.06266775
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.05278692
43	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.03683432
44	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.02135642
45	Butanoate metabolism_Homo sapiens_hsa00650	0.98229204
46	Alzheimers disease_Homo sapiens_hsa05010	0.97742155
47	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.97589006
48	MAPK signaling pathway_Homo sapiens_hsa04010	0.97120216
49	AMPK signaling pathway_Homo sapiens_hsa04152	0.96588572
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.96359671
51	PPAR signaling pathway_Homo sapiens_hsa03320	0.94890844
52	Rap1 signaling pathway_Homo sapiens_hsa04015	0.94798123
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92253013
54	Insulin secretion_Homo sapiens_hsa04911	0.91080694
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.90441452
56	Pancreatic secretion_Homo sapiens_hsa04972	0.86596636
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.84525695
58	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.84401437
59	Fatty acid degradation_Homo sapiens_hsa00071	0.80831711
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.80808116
61	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.79162475
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79030297
63	Renin secretion_Homo sapiens_hsa04924	0.78207354
64	Circadian rhythm_Homo sapiens_hsa04710	0.77821205
65	Notch signaling pathway_Homo sapiens_hsa04330	0.76427682
66	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.75860737
67	VEGF signaling pathway_Homo sapiens_hsa04370	0.73880819
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70849122
69	cAMP signaling pathway_Homo sapiens_hsa04024	0.69733639
70	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.68887602
71	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.67392138
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67135794
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65230224
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.64284192
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63124386
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63001760
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.61715766
78	Retinol metabolism_Homo sapiens_hsa00830	0.61592991
79	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.60341909
80	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.57637813
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55745667
82	mTOR signaling pathway_Homo sapiens_hsa04150	0.55564343
83	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.52653120
84	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.52369039
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50632671
86	Serotonergic synapse_Homo sapiens_hsa04726	0.50531315
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.49009320
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.47879597
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47583418
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47277209
91	Prion diseases_Homo sapiens_hsa05020	0.44843515
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.44215467
93	African trypanosomiasis_Homo sapiens_hsa05143	0.42908743
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41727618
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.39326283
96	Taste transduction_Homo sapiens_hsa04742	0.39153960
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38813088
98	Nicotine addiction_Homo sapiens_hsa05033	0.37893191
99	Ras signaling pathway_Homo sapiens_hsa04014	0.35733664
100	Salivary secretion_Homo sapiens_hsa04970	0.34315116

TSSK1A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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