TSSK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.79345782
2epithelial cilium movement (GO:0003351)9.73348654
3axonemal dynein complex assembly (GO:0070286)9.57815178
4motile cilium assembly (GO:0044458)9.55061845
5* spermatid development (GO:0007286)9.41208659
6reproduction (GO:0000003)9.15153665
7regulation of cilium movement (GO:0003352)8.75366685
8cilium movement (GO:0003341)7.83594694
9cilium or flagellum-dependent cell motility (GO:0001539)7.82501475
10negative regulation of inclusion body assembly (GO:0090084)7.76804133
11rRNA methylation (GO:0031167)7.52190119
12sperm capacitation (GO:0048240)7.41427388
13phosphatidylethanolamine biosynthetic process (GO:0006646)7.40455732
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.13924281
15single fertilization (GO:0007338)7.11616696
16organic cation transport (GO:0015695)7.04844065
17synaptonemal complex organization (GO:0070193)6.99532215
18spermatogenesis (GO:0007283)6.97827703
19male gamete generation (GO:0048232)6.95255907
20synaptonemal complex assembly (GO:0007130)6.91259649
21phosphatidylethanolamine metabolic process (GO:0046337)6.85204339
22microtubule depolymerization (GO:0007019)6.79575428
23protein targeting to Golgi (GO:0000042)6.66333852
24male meiosis (GO:0007140)6.63278542
25response to pheromone (GO:0019236)6.48213512
26piRNA metabolic process (GO:0034587)6.47425660
27regulation of inclusion body assembly (GO:0090083)6.44645987
28gamete generation (GO:0007276)6.38893365
29establishment of protein localization to Golgi (GO:0072600)6.36843767
30rRNA modification (GO:0000154)6.28788988
31retrograde transport, vesicle recycling within Golgi (GO:0000301)6.21454145
32fertilization (GO:0009566)6.09470629
33chromosome condensation (GO:0030261)5.94993638
34calcium ion-dependent exocytosis (GO:0017156)5.81207681
35cellular ketone body metabolic process (GO:0046950)5.64338084
36DNA packaging (GO:0006323)5.62857921
37spermatid nucleus differentiation (GO:0007289)5.39307261
38* cellular process involved in reproduction in multicellular organism (GO:0022412)5.24024071
39* germ cell development (GO:0007281)5.19874576
40glycerol ether metabolic process (GO:0006662)5.19145197
41regulation of microtubule-based movement (GO:0060632)5.17021520
42cell recognition (GO:0008037)5.08532517
43multicellular organismal reproductive process (GO:0048609)5.02541742
44centriole assembly (GO:0098534)4.98825117
45ventricular system development (GO:0021591)4.98115969
46microtubule severing (GO:0051013)4.98018225
47ketone body metabolic process (GO:1902224)4.96941037
48ether metabolic process (GO:0018904)4.79789663
49protein localization to Golgi apparatus (GO:0034067)4.74540386
50sexual reproduction (GO:0019953)4.74234608
51chromosome organization involved in meiosis (GO:0070192)4.60878567
52seminiferous tubule development (GO:0072520)4.60527541
53male meiosis I (GO:0007141)4.53195020
54centriole replication (GO:0007099)4.49277911
55positive regulation of Rab GTPase activity (GO:0032851)4.44550605
56regulation of Rab GTPase activity (GO:0032313)4.44550605
57single strand break repair (GO:0000012)4.42411096
58chaperone-mediated protein complex assembly (GO:0051131)4.34339706
59left/right pattern formation (GO:0060972)4.33098390
60regulation of transcription involved in cell fate commitment (GO:0060850)4.16779829
61DNA methylation involved in gamete generation (GO:0043046)4.13660887
62sequestering of actin monomers (GO:0042989)4.11935723
63meiotic nuclear division (GO:0007126)3.99081782
64* multicellular organismal development (GO:0007275)3.97386604
65response to acidic pH (GO:0010447)3.90723938
66meiosis I (GO:0007127)3.59398459
67protein polyglutamylation (GO:0018095)3.58804611
68protein K11-linked deubiquitination (GO:0035871)3.56570565
69regulation of phosphoprotein phosphatase activity (GO:0043666)3.54879882
70multicellular organismal movement (GO:0050879)3.54553994
71musculoskeletal movement (GO:0050881)3.54553994
72coenzyme catabolic process (GO:0009109)3.52133353
73cellular response to pH (GO:0071467)3.51061944
74regulation of centriole replication (GO:0046599)3.50720865
75microtubule polymerization or depolymerization (GO:0031109)3.48516556
76regulation of spindle checkpoint (GO:0090231)3.42499843
77genitalia morphogenesis (GO:0035112)3.41621518
78peptidyl-threonine dephosphorylation (GO:0035970)3.38135996
79protein refolding (GO:0042026)3.34872588
80homeostasis of number of cells within a tissue (GO:0048873)3.28398111
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25033700
82positive regulation of macrophage activation (GO:0043032)3.22296170
83interferon-gamma secretion (GO:0072643)3.21161544
84nuclear pore organization (GO:0006999)3.19480472
85glycolytic process (GO:0006096)3.18586955
86meiotic cell cycle (GO:0051321)3.15044289
87nucleus organization (GO:0006997)3.14278543
88polyamine biosynthetic process (GO:0006596)3.11817345
89carnitine transport (GO:0015879)3.11798063
90amino-acid betaine transport (GO:0015838)3.11798063
91mitotic sister chromatid cohesion (GO:0007064)3.10445923
92negative regulation of Rho protein signal transduction (GO:0035024)3.09815513
93cranial nerve morphogenesis (GO:0021602)3.08811309
94regulation of interleukin-13 production (GO:0032656)3.07443812
95histone H3-K9 demethylation (GO:0033169)3.02364745
96protein localization to cilium (GO:0061512)2.99190401
97nucleoside diphosphate phosphorylation (GO:0006165)2.98517476
98cerebral cortex neuron differentiation (GO:0021895)2.98093707
99RNA localization (GO:0006403)2.97504276
100polyol catabolic process (GO:0046174)2.96254428
101chromatin silencing (GO:0006342)2.94572417
102RNA destabilization (GO:0050779)2.94375489
103regulation of T-helper 2 cell differentiation (GO:0045628)2.91774522
104carnitine transmembrane transport (GO:1902603)2.91620090
105protein depolymerization (GO:0051261)2.90666502
106monoubiquitinated protein deubiquitination (GO:0035520)2.87814192
107negative regulation of gene expression, epigenetic (GO:0045814)2.87226544
108alditol metabolic process (GO:0019400)2.86906821
109cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.85988442
110mitochondrial fission (GO:0000266)2.84246379
111glomerular visceral epithelial cell development (GO:0072015)2.82566114
112histone exchange (GO:0043486)2.79704014
113regulation of cilium assembly (GO:1902017)2.79277374
114cellular biogenic amine biosynthetic process (GO:0042401)2.79037635
115DNA conformation change (GO:0071103)2.78178701
116microtubule nucleation (GO:0007020)2.75866736
117glomerular epithelial cell development (GO:0072310)2.75719732
118regulation of ARF GTPase activity (GO:0032312)2.74856580
119mitochondrion degradation (GO:0000422)2.71442627
120GTP biosynthetic process (GO:0006183)2.69115652
121cilium organization (GO:0044782)2.68373279
122meiotic cell cycle process (GO:1903046)2.64729786
123cilium morphogenesis (GO:0060271)2.62116969
124microtubule-based movement (GO:0007018)2.61523373
125cellular component assembly involved in morphogenesis (GO:0010927)2.59222168
126cilium assembly (GO:0042384)2.58192397
127synapsis (GO:0007129)2.57192296
128membrane protein intracellular domain proteolysis (GO:0031293)2.55195839
129peptidyl-glutamic acid modification (GO:0018200)2.52950259
130axoneme assembly (GO:0035082)2.51198533
131nucleosome disassembly (GO:0006337)2.45762792
132protein-DNA complex disassembly (GO:0032986)2.45762792
133intraciliary transport (GO:0042073)2.42233446
134positive regulation of glycolytic process (GO:0045821)2.41000280
135sperm motility (GO:0030317)14.3793266
136cell wall macromolecule catabolic process (GO:0016998)13.7259476
137cell wall macromolecule metabolic process (GO:0044036)13.7259476
138fusion of sperm to egg plasma membrane (GO:0007342)12.8693634
139acrosome reaction (GO:0007340)12.7389339
140acrosome assembly (GO:0001675)11.7030129
141sperm-egg recognition (GO:0035036)11.6959452
142binding of sperm to zona pellucida (GO:0007339)10.7057766
143cell-cell recognition (GO:0009988)10.4707441
144multicellular organism reproduction (GO:0032504)10.4113053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.00348909
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19292319
3EZH2_22144423_ChIP-Seq_EOC_Human4.11692989
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.87079455
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22509084
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03722038
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99645980
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92793002
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.87103620
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.78878747
11VDR_22108803_ChIP-Seq_LS180_Human2.65012491
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.34446912
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.26360052
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25870695
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16479889
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.14764496
17ZNF274_21170338_ChIP-Seq_K562_Hela2.08323611
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06711643
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03545582
20RAC3_21632823_ChIP-Seq_H3396_Human2.01294725
21CTCF_27219007_Chip-Seq_Bcells_Human2.00199513
22DROSHA_22980978_ChIP-Seq_HELA_Human1.90133852
23ERA_21632823_ChIP-Seq_H3396_Human1.89018210
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84964743
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.83704856
26FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82840382
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.80897501
28FUS_26573619_Chip-Seq_HEK293_Human1.80443824
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79546968
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78128200
31SOX2_22085726_ChIP-Seq_NPCs_Mouse1.73579007
32STAT1_17558387_ChIP-Seq_HELA_Human1.72703238
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.71121576
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67111403
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.65874979
36SMC4_20622854_ChIP-Seq_HELA_Human1.65073093
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.64928880
38OCT4_20526341_ChIP-Seq_ESCs_Human1.63425763
39P68_20966046_ChIP-Seq_HELA_Human1.59311815
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.58710300
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.58268387
42MYC_19829295_ChIP-Seq_ESCs_Human1.53521994
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52853174
44FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52307534
45E2F1_20622854_ChIP-Seq_HELA_Human1.50186692
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49880035
47* TAF2_19829295_ChIP-Seq_ESCs_Human1.49543608
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48392841
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.48358153
50* TP63_22573176_ChIP-Seq_HFKS_Human1.47827685
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47805028
52* LXR_22292898_ChIP-Seq_THP-1_Human1.47016511
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46596362
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45809769
55P300_27268052_Chip-Seq_Bcells_Human1.43891555
56ER_23166858_ChIP-Seq_MCF-7_Human1.43475760
57AR_25329375_ChIP-Seq_VCAP_Human1.43470590
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.43305673
59P53_21459846_ChIP-Seq_SAOS-2_Human1.42255442
60* PHF8_20622854_ChIP-Seq_HELA_Human1.41846427
61KDM2B_26808549_Chip-Seq_REH_Human1.40716600
62LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38026083
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.37802043
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37119946
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36091014
66CBP_20019798_ChIP-Seq_JUKART_Human1.35490781
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35490781
68TP53_18474530_ChIP-ChIP_U2OS_Human1.34459816
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33799083
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33444082
71RBPJ_21746931_ChIP-Seq_IB4_Human1.33404302
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.33329651
73REST_21632747_ChIP-Seq_MESCs_Mouse1.33274315
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29844450
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29259195
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.29245971
77HNFA_21074721_ChIP-Seq_CACO-2_Human1.28357682
78CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27674470
79RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27291932
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27010400
81GF1_26923725_Chip-Seq_HPCs_Mouse1.25956424
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24394283
83CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23749548
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23287380
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23053688
86ETV1_20927104_ChIP-Seq_GIST48_Human1.22448232
87CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20547765
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20325777
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.20099049
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19294750
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.18970546
92SPI1_26923725_Chip-Seq_HPCs_Mouse1.17958845
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17674720
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.16873887
95CEBPB_22108803_ChIP-Seq_LS180_Human1.14911842
96P300_19829295_ChIP-Seq_ESCs_Human1.14743735
97MYC_27129775_Chip-Seq_CORNEA_Mouse1.14517252
98TBL1_22424771_ChIP-Seq_293T_Human1.14053403
99GATA1_19941827_ChIP-Seq_MEL86_Mouse1.13687326
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13664167
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.13565577
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13075356
103SMAD3_21741376_ChIP-Seq_ESCs_Human1.12672215
104SMRT_27268052_Chip-Seq_Bcells_Human1.12323813
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12179325
106RUNX_20019798_ChIP-Seq_JUKART_Human1.11715472
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11332305
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.11124176
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.10314074
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10121933
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09983918
112JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09979924
113ERG_20517297_ChIP-Seq_VCAP_Human1.09529464
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.09216967
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09137875
116SMAD4_21799915_ChIP-Seq_A2780_Human1.09133985
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08556865
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08512872
119OCT1_27270436_Chip-Seq_PROSTATE_Human1.08376962
120RARA_24833708_ChIP-Seq_LIVER_Mouse1.07031355
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06867854
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06867854
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.06832294
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06559945
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06348713
126SA1_27219007_Chip-Seq_Bcells_Human1.06343176
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.06226434
128CTCF_20526341_ChIP-Seq_ESCs_Human1.05824942
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05663509
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05206483
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03963416
132GATA6_21074721_ChIP-Seq_CACO-2_Human1.03844928
133PHF8_20622853_ChIP-Seq_HELA_Human1.03206733
134OCT4_19829295_ChIP-Seq_ESCs_Human1.03018784
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02520338
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02394344
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02292027
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00860524
139PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99961437
140BCOR_27268052_Chip-Seq_Bcells_Human0.99866324
141NANOG_19829295_ChIP-Seq_ESCs_Human0.99577824
142SOX2_19829295_ChIP-Seq_ESCs_Human0.99577824
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.99461025
144* ESET_19884257_ChIP-Seq_ESCs_Mouse0.99186994
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.99116348
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99098976
147CRX_20693478_ChIP-Seq_RETINA_Mouse0.99061748
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98936254
149SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97867133
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97245559
151KLF4_19829295_ChIP-Seq_ESCs_Human0.97053651
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.96221615
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95265153
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95115683
155SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94395092
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.93095342
157RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91102017
158NFYB_21822215_ChIP-Seq_K562_Human0.90210960
159KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90138525
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90082525
161NANOG_20526341_ChIP-Seq_ESCs_Human0.89742243
162TAF15_26573619_Chip-Seq_HEK293_Human0.88062930
163OCT4_18555785_Chip-Seq_ESCs_Mouse0.87592287
164MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87383623
165NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86012724
166BCL6_27268052_Chip-Seq_Bcells_Human0.85221918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.98481302
2* MP0001929_abnormal_gametogenesis5.44090453
3MP0008877_abnormal_DNA_methylation3.83084392
4* MP0002161_abnormal_fertility/fecundity3.25561735
5MP0005670_abnormal_white_adipose3.14788059
6* MP0002210_abnormal_sex_determination3.10109065
7* MP0001145_abnormal_male_reproductive2.65422183
8MP0000678_abnormal_parathyroid_gland2.33691682
9* MP0000653_abnormal_sex_gland2.29274962
10MP0003718_maternal_effect2.16566928
11MP0002653_abnormal_ependyma_morphology2.08761465
12MP0005410_abnormal_fertilization16.9317797
13MP0005423_abnormal_somatic_nervous1.73692514
14MP0001485_abnormal_pinna_reflex1.71290663
15MP0004233_abnormal_muscle_weight1.56996045
16MP0003646_muscle_fatigue1.51363062
17MP0002249_abnormal_larynx_morphology1.43894964
18MP0002160_abnormal_reproductive_system1.41906914
19MP0005379_endocrine/exocrine_gland_phen1.31220040
20MP0005623_abnormal_meninges_morphology1.24378932
21MP0001486_abnormal_startle_reflex1.23477032
22MP0002822_catalepsy1.21335828
23MP0005310_abnormal_salivary_gland1.17918884
24MP0002234_abnormal_pharynx_morphology1.11767188
25MP0002138_abnormal_hepatobiliary_system1.10676847
26MP0009053_abnormal_anal_canal1.10377064
27MP0002127_abnormal_cardiovascular_syste1.09482544
28MP0001765_abnormal_ion_homeostasis1.08246991
29MP0002282_abnormal_trachea_morphology1.06717838
30MP0004859_abnormal_synaptic_plasticity1.06524901
31MP0001984_abnormal_olfaction1.05695371
32MP0002735_abnormal_chemical_nociception1.04356221
33MP0005395_other_phenotype0.99106738
34MP0001963_abnormal_hearing_physiology0.98525144
35MP0005451_abnormal_body_composition0.90888103
36MP0008789_abnormal_olfactory_epithelium0.90674531
37MP0000049_abnormal_middle_ear0.87876280
38MP0000026_abnormal_inner_ear0.86107996
39MP0005248_abnormal_Harderian_gland0.78540082
40MP0005647_abnormal_sex_gland0.77922882
41MP0001905_abnormal_dopamine_level0.77306689
42MP0002067_abnormal_sensory_capabilities0.77231479
43MP0008058_abnormal_DNA_repair0.75618161
44MP0000955_abnormal_spinal_cord0.75141724
45MP0005394_taste/olfaction_phenotype0.73615394
46MP0005499_abnormal_olfactory_system0.73615394
47MP0003011_delayed_dark_adaptation0.71130818
48MP0009046_muscle_twitch0.70462947
49MP0003115_abnormal_respiratory_system0.70308679
50MP0000681_abnormal_thyroid_gland0.70157776
51MP0004084_abnormal_cardiac_muscle0.69415329
52MP0003828_pulmonary_edema0.69109951
53MP0009697_abnormal_copulation0.68549284
54MP0005389_reproductive_system_phenotype0.66697197
55MP0002557_abnormal_social/conspecific_i0.64815760
56MP0003878_abnormal_ear_physiology0.63277551
57MP0005377_hearing/vestibular/ear_phenot0.63277551
58MP0005083_abnormal_biliary_tract0.62932508
59MP0008995_early_reproductive_senescence0.62351364
60MP0004085_abnormal_heartbeat0.61672005
61MP0003329_amyloid_beta_deposits0.61547285
62MP0005666_abnormal_adipose_tissue0.61267141
63MP0005636_abnormal_mineral_homeostasis0.61096962
64MP0001270_distended_abdomen0.57809242
65MP0003077_abnormal_cell_cycle0.57600748
66MP0004510_myositis0.55587990
67MP0001879_abnormal_lymphatic_vessel0.55327916
68MP0003091_abnormal_cell_migration0.54302849
69MP0001529_abnormal_vocalization0.53866843
70MP0002736_abnormal_nociception_after0.53724599
71MP0001324_abnormal_eye_pigmentation0.53570463
72MP0004036_abnormal_muscle_relaxation0.53497936
73MP0002269_muscular_atrophy0.51463814
74MP0001764_abnormal_homeostasis0.49411526
75MP0001293_anophthalmia0.48872947
76MP0000470_abnormal_stomach_morphology0.46046309
77MP0005167_abnormal_blood-brain_barrier0.45704301
78MP0004484_altered_response_of0.44767387
79MP0000358_abnormal_cell_content/0.44361660
80MP0008961_abnormal_basal_metabolism0.44267453
81MP0000749_muscle_degeneration0.43432532
82MP0000534_abnormal_ureter_morphology0.43416611
83MP0002572_abnormal_emotion/affect_behav0.43414698
84MP0003699_abnormal_female_reproductive0.43234091
85MP0003632_abnormal_nervous_system0.43157110
86MP0000230_abnormal_systemic_arterial0.42692501
87MP0002272_abnormal_nervous_system0.41725437
88MP0006036_abnormal_mitochondrial_physio0.41662063
89MP0009745_abnormal_behavioral_response0.41390084
90MP0000613_abnormal_salivary_gland0.40184696
91MP0005397_hematopoietic_system_phenotyp0.39545020
92MP0001545_abnormal_hematopoietic_system0.39545020
93MP0004133_heterotaxia0.38808960
94MP0000249_abnormal_blood_vessel0.38578132
95MP0002928_abnormal_bile_duct0.38061057
96MP0002734_abnormal_mechanical_nocicepti0.37433836
97MP0002733_abnormal_thermal_nociception0.37105672
98MP0009278_abnormal_bone_marrow0.37078851
99MP0000569_abnormal_digit_pigmentation0.37025926
100MP0005253_abnormal_eye_physiology0.36966146
101MP0000003_abnormal_adipose_tissue0.36689004
102MP0009115_abnormal_fat_cell0.35946116
103MP0003787_abnormal_imprinting0.35519579
104MP0005084_abnormal_gallbladder_morpholo0.35362848
105MP0005551_abnormal_eye_electrophysiolog0.35277656
106MP0005332_abnormal_amino_acid0.35259504
107MP0001666_abnormal_nutrient_absorption0.34960238
108MP0006276_abnormal_autonomic_nervous0.34859940
109MP0005595_abnormal_vascular_smooth0.34842049
110MP0001873_stomach_inflammation0.34554480
111MP0010094_abnormal_chromosome_stability0.33854159
112MP0000604_amyloidosis0.32398901
113MP0004811_abnormal_neuron_physiology0.30521443
114MP0005391_vision/eye_phenotype0.29723757
115MP0003942_abnormal_urinary_system0.29667114
116MP0001968_abnormal_touch/_nociception0.29477141
117MP0003633_abnormal_nervous_system0.28580312
118MP0002139_abnormal_hepatobiliary_system0.28175512
119MP0003950_abnormal_plasma_membrane0.27566197
120MP0001730_embryonic_growth_arrest0.27564780
121MP0002971_abnormal_brown_adipose0.27086566
122MP0003861_abnormal_nervous_system0.26173453
123MP0003111_abnormal_nucleus_morphology0.25795642
124MP0002169_no_abnormal_phenotype0.24797665
125MP0002873_normal_phenotype0.24565376
126MP0001849_ear_inflammation0.23556535
127MP0003948_abnormal_gas_homeostasis0.23177117
128MP0003879_abnormal_hair_cell0.23119379
129MP0002152_abnormal_brain_morphology0.23046757
130MP0003631_nervous_system_phenotype0.22973991
131MP0002102_abnormal_ear_morphology0.22047421
132MP0004019_abnormal_vitamin_homeostasis0.21656653
133MP0001119_abnormal_female_reproductive0.21278560
134MP0006035_abnormal_mitochondrial_morpho0.19834283
135MP0004742_abnormal_vestibular_system0.19812621
136MP0002295_abnormal_pulmonary_circulatio0.19623268
137MP0005375_adipose_tissue_phenotype0.19460667
138MP0004270_analgesia0.18069970
139MP0002092_abnormal_eye_morphology0.17918015
140MP0004145_abnormal_muscle_electrophysio0.17059287
141MP0008875_abnormal_xenobiotic_pharmacok0.16123020
142MP0004043_abnormal_pH_regulation0.15470914
143MP0008569_lethality_at_weaning0.15169997
144MP0002693_abnormal_pancreas_physiology0.14797990
145MP0000001_mammalian_phenotype0.14649457
146MP0005365_abnormal_bile_salt0.14579987
147MP0002229_neurodegeneration0.13773827
148MP0000462_abnormal_digestive_system0.13684598
149MP0002909_abnormal_adrenal_gland0.13347513
150MP0005319_abnormal_enzyme/_coenzyme0.12716919
151MP0002132_abnormal_respiratory_system0.12491573
152MP0002118_abnormal_lipid_homeostasis0.12392794
153MP0010307_abnormal_tumor_latency0.12373892
154MP0002084_abnormal_developmental_patter0.12369565
155MP0000751_myopathy0.12341231
156MP0003806_abnormal_nucleotide_metabolis0.12319997
157MP0000313_abnormal_cell_death0.12216911
158MP0002405_respiratory_system_inflammati0.11289718
159MP0001348_abnormal_lacrimal_gland0.11007605
160MP0003959_abnormal_lean_body0.10796049

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.37756404
2Abnormal respiratory motile cilium morphology (HP:0005938)9.29638553
3Abnormal respiratory epithelium morphology (HP:0012253)9.29638553
4Severe visual impairment (HP:0001141)7.87545342
5Rhinitis (HP:0012384)7.48301769
6Chronic bronchitis (HP:0004469)7.47298627
7Abnormal ciliary motility (HP:0012262)7.24536444
8Infertility (HP:0000789)7.20602289
9Nasal polyposis (HP:0100582)6.46356329
10Abnormality of the nasal mucosa (HP:0000433)5.31243920
11Chronic hepatic failure (HP:0100626)5.29485851
12Attenuation of retinal blood vessels (HP:0007843)5.26883375
13Bony spicule pigmentary retinopathy (HP:0007737)5.16030555
14Resting tremor (HP:0002322)5.04686518
15Male infertility (HP:0003251)4.91097634
16Hyperkalemia (HP:0002153)4.88911908
17Bronchitis (HP:0012387)4.64578095
18Bronchiectasis (HP:0002110)4.42142464
19Abnormal rod and cone electroretinograms (HP:0008323)4.36742037
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.19729757
21Abnormality of macular pigmentation (HP:0008002)4.10833029
22Nephronophthisis (HP:0000090)3.95322230
23Potter facies (HP:0002009)3.92988402
24Facial shape deformation (HP:0011334)3.92988402
25Cone-rod dystrophy (HP:0000548)3.82296739
26Abnormal spermatogenesis (HP:0008669)3.72282306
27Hypoalphalipoproteinemia (HP:0003233)3.52888344
28Hypoplasia of the thymus (HP:0000778)3.34188043
29Recurrent otitis media (HP:0000403)3.31897645
30Postural instability (HP:0002172)3.28668492
31Progressive sensorineural hearing impairment (HP:0000408)3.24475629
32Recurrent sinusitis (HP:0011108)3.15175751
33Menstrual irregularities (HP:0000858)3.05784284
34Abnormality of the renal medulla (HP:0100957)2.94433921
35Aplasia/Hypoplasia of the earlobes (HP:0009906)2.94111923
36Renovascular hypertension (HP:0100817)2.83228240
37Impulsivity (HP:0100710)2.81983115
38Generalized aminoaciduria (HP:0002909)2.80672227
39Recurrent bronchitis (HP:0002837)2.76097741
40Enlarged epiphyses (HP:0010580)2.74094679
41Hypoplastic ischia (HP:0003175)2.69648128
42Tubulointerstitial nephritis (HP:0001970)2.61162020
43Cholecystitis (HP:0001082)2.61144823
44Abnormal gallbladder physiology (HP:0012438)2.61144823
45Abnormality of potassium homeostasis (HP:0011042)2.57974949
46Insulin-resistant diabetes mellitus (HP:0000831)2.56523853
47Unilateral renal agenesis (HP:0000122)2.51061191
48Progressive cerebellar ataxia (HP:0002073)2.48783031
49Tubular atrophy (HP:0000092)2.46690178
50Abnormality of the ischium (HP:0003174)2.45206460
51Portal hypertension (HP:0001409)2.44180065
52Amelogenesis imperfecta (HP:0000705)2.43190389
53Abnormality of midbrain morphology (HP:0002418)2.43118838
54Molar tooth sign on MRI (HP:0002419)2.43118838
55Abnormality of the hepatic vasculature (HP:0006707)2.36486835
56Abnormality of the aortic arch (HP:0012303)2.34491589
57Medial flaring of the eyebrow (HP:0010747)2.34307124
58Abnormality of dental color (HP:0011073)2.33741567
59Gonadotropin excess (HP:0000837)2.32234822
60Tubulointerstitial abnormality (HP:0001969)2.30864635
61Azoospermia (HP:0000027)2.27290640
62Abnormality of the costochondral junction (HP:0000919)2.26480917
63Flattened epiphyses (HP:0003071)2.25173677
64Dyschromatopsia (HP:0007641)2.24957091
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23602158
66Myokymia (HP:0002411)2.22973300
67Congenital sensorineural hearing impairment (HP:0008527)2.21894166
68Polyuria (HP:0000103)2.14355410
69Abnormality of the parathyroid morphology (HP:0011766)2.13345380
70Increased purine levels (HP:0004368)2.09727522
71Hyperuricemia (HP:0002149)2.09727522
72Choroideremia (HP:0001139)2.08450455
73Spastic tetraparesis (HP:0001285)2.02183404
74Dynein arm defect of respiratory motile cilia (HP:0012255)13.3605947
75Absent/shortened dynein arms (HP:0200106)13.3605947
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0716473
77Decreased central vision (HP:0007663)1.99145816
78Progressive hearing impairment (HP:0001730)1.96712480
79Widely patent fontanelles and sutures (HP:0004492)1.95619523
80Recurrent pneumonia (HP:0006532)1.94622210
81Tubulointerstitial fibrosis (HP:0005576)1.92595734
82Congenital malformation of the right heart (HP:0011723)1.92237170
83Double outlet right ventricle (HP:0001719)1.92237170
84Optic nerve hypoplasia (HP:0000609)1.87726214
85Osteomalacia (HP:0002749)1.87237447
86Muscle fiber atrophy (HP:0100295)1.86810322
87Ventricular tachycardia (HP:0004756)1.86437757
88Hemorrhage of the eye (HP:0011885)1.84962372
89Upper limb muscle weakness (HP:0003484)1.84578776
90Obsessive-compulsive behavior (HP:0000722)1.82887598
91Renal Fanconi syndrome (HP:0001994)1.80546871
92Neurofibrillary tangles (HP:0002185)1.79703119
93Subcapsular cataract (HP:0000523)1.78715951
94Hyponatremia (HP:0002902)1.77752624
95Hypophosphatemic rickets (HP:0004912)1.77253982
96Photophobia (HP:0000613)1.76254051
97Abnormality of urine glucose concentration (HP:0011016)1.74710810
98Glycosuria (HP:0003076)1.74710810
99Abnormal drinking behavior (HP:0030082)1.72703228
100Polydipsia (HP:0001959)1.72703228
101Epiphyseal dysplasia (HP:0002656)1.72610551
102Abnormality of chloride homeostasis (HP:0011422)1.69778723
103Postaxial foot polydactyly (HP:0001830)1.68777194
104Occipital encephalocele (HP:0002085)1.67587242
105Hypolipoproteinemia (HP:0010981)1.66970519
106Tetany (HP:0001281)1.66547115
107Bile duct proliferation (HP:0001408)1.66490094
108Abnormal biliary tract physiology (HP:0012439)1.66490094
109Heterotopia (HP:0002282)1.66434351
110Stage 5 chronic kidney disease (HP:0003774)1.64664239
111Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61376213
112Congenital hepatic fibrosis (HP:0002612)1.60760792
113Abnormality of renal excretion (HP:0011036)1.60239420
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58681239
115Aplasia/Hypoplasia of the lens (HP:0008063)1.57331204
116Easy fatigability (HP:0003388)1.50719405
117Bell-shaped thorax (HP:0001591)1.50201663
118Exercise-induced myalgia (HP:0003738)1.49238271
119Short ribs (HP:0000773)1.48737766
120Asymmetric septal hypertrophy (HP:0001670)1.46793911
121Bundle branch block (HP:0011710)1.44670671
122Cerebral inclusion bodies (HP:0100314)1.44569380
123Abnormality of the renal cortex (HP:0011035)1.44086315
124Abnormality of dentin (HP:0010299)1.41464965
125Abnormality of the dental root (HP:0006486)1.40971914
126Taurodontia (HP:0000679)1.40971914
127Abnormality of permanent molar morphology (HP:0011071)1.40971914
128Oculomotor apraxia (HP:0000657)1.40949449
129Fatigable weakness (HP:0003473)1.39439657
130Abnormality of the neuromuscular junction (HP:0003398)1.39439657
131Postaxial hand polydactyly (HP:0001162)1.37358413
132Myoglobinuria (HP:0002913)1.37160763
133Facial cleft (HP:0002006)1.37154377
134Renal dysplasia (HP:0000110)1.37093456
135Sensory axonal neuropathy (HP:0003390)1.36733249
136Abnormal urine output (HP:0012590)1.36477887
137Loss of speech (HP:0002371)1.35037202
138Hypercholesterolemia (HP:0003124)1.34073395
139Abnormality of the dental pulp (HP:0006479)1.32767412
140Constricted visual fields (HP:0001133)1.32520954
141Cystic liver disease (HP:0006706)1.29695593
142Abnormality of molar (HP:0011077)1.29369144
143Abnormality of molar morphology (HP:0011070)1.29369144
144Chronic sinusitis (HP:0011109)1.29257395
145Congenital primary aphakia (HP:0007707)1.27568649
146Gait imbalance (HP:0002141)1.27522440
147Fibular hypoplasia (HP:0003038)1.27225254
148Deformed sella turcica (HP:0002681)1.26804606
149Cerebellar dysplasia (HP:0007033)1.25040793
150Hemiparesis (HP:0001269)1.25017122
151Rhabdomyolysis (HP:0003201)1.24160445
152Absent epiphyses (HP:0010577)1.23784032
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23784032
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23070036
155Type 2 muscle fiber atrophy (HP:0003554)1.21974761
156Neoplasm of the heart (HP:0100544)1.20514313
157Exercise-induced muscle cramps (HP:0003710)1.18323871
158Broad distal phalanx of finger (HP:0009836)1.18237897
159Short femoral neck (HP:0100864)1.17537099
160Truncal obesity (HP:0001956)1.16842776
161Generalized muscle weakness (HP:0003324)1.15201133
162Retinal dysplasia (HP:0007973)1.14993931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.75560607
2PDK37.75560607
3TESK17.00603413
4PRKD35.30743932
5PDK25.02296902
6ICK4.81377838
7DDR23.89630329
8MAP4K23.14688053
9BRD42.86287642
10INSRR2.56490410
11PLK22.51616842
12PTK2B2.16425271
13WNK42.13837466
14STK392.08496587
15STK382.00382430
16MST1R1.95787664
17DYRK1B1.84981788
18PNCK1.64309981
19NEK21.59738442
20CDK121.32740825
21PIK3CG1.31490891
22PDK11.29192539
23MAP3K91.25587539
24AKT31.18638333
25KSR21.08067323
26SIK21.06323054
27DYRK31.05432215
28NEK11.03965505
29CDK70.98358172
30CAMK1D0.97107829
31PDPK10.88338397
32RIPK40.87034526
33IRAK10.85417239
34MAPK150.85035198
35TYRO30.84076282
36TESK20.82156841
37LATS10.77867230
38EEF2K0.77163882
39WNK10.75775027
40RPS6KA20.75773026
41CDK30.73060168
42PASK0.72965705
43SGK4940.71710570
44SGK2230.71710570
45CCNB10.71469468
46LATS20.70968727
47ROCK10.62069129
48MAP3K20.61865794
49BMPR1B0.61713098
50CHEK20.58757841
51STK30.58630753
52NTRK20.58564732
53PINK10.58419530
54CAMK10.56995419
55ARAF0.56363231
56TTK0.55483541
57ZAK0.54510896
58MAP3K110.53324005
59MUSK0.51555974
60MAP2K60.51485688
61MAP2K20.51234695
62MAP3K80.51209410
63IRAK20.48135511
64VRK20.46295333
65UHMK10.46084850
66TIE10.44821517
67LMTK20.42581150
68MAP3K100.42565061
69PAK10.41260804
70PRKAA20.40770048
71MAPK10.40409870
72PRKCG0.40400782
73CAMK1G0.40095138
74STK38L0.40075530
75VRK10.38682510
76TLK10.38607217
77SGK10.34511768
78CHEK10.34416757
79MAPKAPK50.33720435
80MARK20.30990736
81MYLK0.28651138
82PAK40.27942326
83PAK20.27539224
84NTRK30.27528498
85MET0.26335700
86MARK10.25360425
87CAMKK10.24684745
88MINK10.23724999
89CAMK40.23014305
90MAPK140.22886260
91MTOR0.22859023
92ATM0.22032268
93RPS6KL10.21999852
94RPS6KC10.21999852
95PRKCZ0.21629558
96MAPK100.21341857
97RPS6KA60.21006835
98CDK150.20589912
99PLK40.19335688
100BRSK20.18861659
101ATR0.18773152
102PRKCQ0.18263094
103BLK0.18098694
104CDK180.17655839
105PRKAA10.17103926
106CDK11A0.16922638
107OXSR10.16125800
108PRKACB0.15884411
109RPS6KB10.14300632
110WEE10.13907111
111NEK60.13455651
112OBSCN0.13321443
113PRKG20.13055178
114SGK20.12386561
115CDK140.11951629
116RPS6KA50.11690252
117BRSK10.11470926
118AKT10.11266857
119PLK10.10596743
120RPS6KA10.10488129
121MAPK110.10036281
122STK100.09592663
123MARK30.09468200
124BRAF0.07414428
125CSNK2A10.07117706
126CDK60.06632109
127CSF1R0.06527158
128GSK3B0.05967146
129PRKCD0.04658590
130STK110.04393561
131PKN10.04079213
132PIM10.03866866
133CAMK2A0.03791849
134CLK10.03443923
135PRKG10.02824506
136MAPK80.02455237
137PRKACG0.02352441
138AURKA0.01929091
139PRKCA0.01256684
140PRKCB0.01237962
141CDK20.00482883
142CDK10.00291069
143CSNK2A20.00214676
144PAK6-0.0463453
145PRKACA-0.0403681
146RPS6KA3-0.0398830
147TRIB3-0.0305146
148CDC7-0.0292762
149BMPR2-0.0291436
150EPHB1-0.0281248
151MAP3K1-0.0212188
152CSNK1D-0.0139815
153ZAP70-0.0102833
154PDGFRB-0.0086912
155EGFR-0.0059967
156YES1-0.0043055
157CDK4-0.0013707

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.31985928
2Fatty acid biosynthesis_Homo sapiens_hsa000614.89782293
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.46520545
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.39601336
5Vitamin B6 metabolism_Homo sapiens_hsa007503.31328271
6Olfactory transduction_Homo sapiens_hsa047403.26854597
7Linoleic acid metabolism_Homo sapiens_hsa005913.23407763
8Pyruvate metabolism_Homo sapiens_hsa006203.20122593
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.91126559
10Butanoate metabolism_Homo sapiens_hsa006502.58654088
11Glucagon signaling pathway_Homo sapiens_hsa049222.53287545
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.45149756
13Propanoate metabolism_Homo sapiens_hsa006402.40979104
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27891454
15Basal transcription factors_Homo sapiens_hsa030222.14441424
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02499046
17Glycerolipid metabolism_Homo sapiens_hsa005611.97376280
18Selenocompound metabolism_Homo sapiens_hsa004501.95199109
19PPAR signaling pathway_Homo sapiens_hsa033201.93254184
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.89900755
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.79982229
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.70331384
23Fructose and mannose metabolism_Homo sapiens_hsa000511.65301978
24Fat digestion and absorption_Homo sapiens_hsa049751.65062913
25Fatty acid degradation_Homo sapiens_hsa000711.56531286
26Mineral absorption_Homo sapiens_hsa049781.55383318
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53718381
28Pentose phosphate pathway_Homo sapiens_hsa000301.53375703
29Ether lipid metabolism_Homo sapiens_hsa005651.52483623
30Amphetamine addiction_Homo sapiens_hsa050311.52264521
31Fatty acid metabolism_Homo sapiens_hsa012121.51146473
32Oocyte meiosis_Homo sapiens_hsa041141.49575941
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.34162581
34Carbon metabolism_Homo sapiens_hsa012001.33952361
35Type II diabetes mellitus_Homo sapiens_hsa049301.30788341
36Cardiac muscle contraction_Homo sapiens_hsa042601.27733152
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21909015
38Phenylalanine metabolism_Homo sapiens_hsa003601.20442473
39Dorso-ventral axis formation_Homo sapiens_hsa043201.20263948
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11240050
41Glutathione metabolism_Homo sapiens_hsa004801.07639196
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04966661
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.04341057
44Renin secretion_Homo sapiens_hsa049241.04044613
45Arginine biosynthesis_Homo sapiens_hsa002201.03076315
46Hedgehog signaling pathway_Homo sapiens_hsa043401.02457971
47Antigen processing and presentation_Homo sapiens_hsa046121.00846195
48Phototransduction_Homo sapiens_hsa047441.00809100
49Purine metabolism_Homo sapiens_hsa002300.98277272
50Collecting duct acid secretion_Homo sapiens_hsa049660.97763763
51Morphine addiction_Homo sapiens_hsa050320.96300316
52Fanconi anemia pathway_Homo sapiens_hsa034600.95801955
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93563392
54Arachidonic acid metabolism_Homo sapiens_hsa005900.91318527
55Chemical carcinogenesis_Homo sapiens_hsa052040.89007100
56Type I diabetes mellitus_Homo sapiens_hsa049400.88805550
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.86520155
58Nitrogen metabolism_Homo sapiens_hsa009100.85685487
59Insulin secretion_Homo sapiens_hsa049110.85045532
60Biosynthesis of amino acids_Homo sapiens_hsa012300.82779372
61mRNA surveillance pathway_Homo sapiens_hsa030150.80762677
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79784945
63Huntingtons disease_Homo sapiens_hsa050160.79039357
64Bile secretion_Homo sapiens_hsa049760.77832460
65Thyroid hormone synthesis_Homo sapiens_hsa049180.75974311
66Long-term potentiation_Homo sapiens_hsa047200.74093245
67Allograft rejection_Homo sapiens_hsa053300.73387123
68Estrogen signaling pathway_Homo sapiens_hsa049150.73380109
69Autoimmune thyroid disease_Homo sapiens_hsa053200.73157184
70Arginine and proline metabolism_Homo sapiens_hsa003300.72647791
71Gap junction_Homo sapiens_hsa045400.72495722
72Glutamatergic synapse_Homo sapiens_hsa047240.69975514
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68659406
74Graft-versus-host disease_Homo sapiens_hsa053320.67028030
75GABAergic synapse_Homo sapiens_hsa047270.65062553
76Nicotine addiction_Homo sapiens_hsa050330.64188473
77Viral myocarditis_Homo sapiens_hsa054160.63725273
78Systemic lupus erythematosus_Homo sapiens_hsa053220.63696994
79MAPK signaling pathway_Homo sapiens_hsa040100.59317916
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59277393
81Pancreatic secretion_Homo sapiens_hsa049720.59218872
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.59208037
83Renin-angiotensin system_Homo sapiens_hsa046140.58383447
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58346048
85Legionellosis_Homo sapiens_hsa051340.57982325
86RNA transport_Homo sapiens_hsa030130.57979226
87Influenza A_Homo sapiens_hsa051640.56053676
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55940350
89Tight junction_Homo sapiens_hsa045300.55572485
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.54831392
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53460580
92Salivary secretion_Homo sapiens_hsa049700.53370005
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52059428
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50674763
95ABC transporters_Homo sapiens_hsa020100.50025486
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.49929066
97Synaptic vesicle cycle_Homo sapiens_hsa047210.49450919
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48589328
99Protein digestion and absorption_Homo sapiens_hsa049740.48200889
100Sulfur metabolism_Homo sapiens_hsa009200.45356933
101Oxytocin signaling pathway_Homo sapiens_hsa049210.45199992
102Endocytosis_Homo sapiens_hsa041440.44982813
103Calcium signaling pathway_Homo sapiens_hsa040200.44944463
104AMPK signaling pathway_Homo sapiens_hsa041520.43472123
105Gastric acid secretion_Homo sapiens_hsa049710.42990367
106Tyrosine metabolism_Homo sapiens_hsa003500.42510162
107Serotonergic synapse_Homo sapiens_hsa047260.39690913
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.39601343
109Cholinergic synapse_Homo sapiens_hsa047250.39390323
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38977572
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38064112
112Metabolic pathways_Homo sapiens_hsa011000.36280713
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36108997
114Alcoholism_Homo sapiens_hsa050340.35261503
115Circadian rhythm_Homo sapiens_hsa047100.35198661
116VEGF signaling pathway_Homo sapiens_hsa043700.34993385
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34881347
118Inositol phosphate metabolism_Homo sapiens_hsa005620.34654347
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31011560
120Retinol metabolism_Homo sapiens_hsa008300.30935785
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30727867
122cAMP signaling pathway_Homo sapiens_hsa040240.29756879
123Pyrimidine metabolism_Homo sapiens_hsa002400.29613345
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29084730
125Cocaine addiction_Homo sapiens_hsa050300.24039803
126Adherens junction_Homo sapiens_hsa045200.21927579
127Circadian entrainment_Homo sapiens_hsa047130.20808019
128Acute myeloid leukemia_Homo sapiens_hsa052210.20520750
129Taste transduction_Homo sapiens_hsa047420.20170282
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.12992911
131B cell receptor signaling pathway_Homo sapiens_hsa046620.12368323
132Salmonella infection_Homo sapiens_hsa051320.10532648
133Wnt signaling pathway_Homo sapiens_hsa043100.10521972
134HIF-1 signaling pathway_Homo sapiens_hsa040660.09575240
135Basal cell carcinoma_Homo sapiens_hsa052170.08589450
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08432229
137Insulin resistance_Homo sapiens_hsa049310.03749570
138Viral carcinogenesis_Homo sapiens_hsa052030.03514413

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