TSSK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.93585600
2plasma membrane fusion (GO:0045026)9.72883679
3axonemal dynein complex assembly (GO:0070286)9.50068971
4epithelial cilium movement (GO:0003351)9.40878268
5reproduction (GO:0000003)9.11523516
6motile cilium assembly (GO:0044458)9.11421497
7regulation of cilium movement (GO:0003352)8.65243101
8cilium or flagellum-dependent cell motility (GO:0001539)8.17618087
9cilium movement (GO:0003341)7.67810357
10negative regulation of inclusion body assembly (GO:0090084)7.26560901
11single fertilization (GO:0007338)7.22471663
12sperm capacitation (GO:0048240)7.20695948
13synaptonemal complex organization (GO:0070193)7.13161031
14synaptonemal complex assembly (GO:0007130)7.05796263
15organic cation transport (GO:0015695)6.99276367
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.96057168
17male meiosis (GO:0007140)6.86038901
18* spermatogenesis (GO:0007283)6.85114035
19* male gamete generation (GO:0048232)6.82587945
20piRNA metabolic process (GO:0034587)6.63119785
21protein targeting to Golgi (GO:0000042)6.39483501
22microtubule depolymerization (GO:0007019)6.39361878
23* gamete generation (GO:0007276)6.26782283
24phosphatidylethanolamine biosynthetic process (GO:0006646)6.23504419
25fertilization (GO:0009566)6.22405366
26regulation of inclusion body assembly (GO:0090083)6.06912546
27establishment of protein localization to Golgi (GO:0072600)6.06278430
28retrograde transport, vesicle recycling within Golgi (GO:0000301)6.04598562
29chromosome condensation (GO:0030261)5.80327441
30calcium ion-dependent exocytosis (GO:0017156)5.71672180
31phosphatidylethanolamine metabolic process (GO:0046337)5.70249439
32rRNA methylation (GO:0031167)5.69238043
33DNA packaging (GO:0006323)5.56059480
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.52662318
35germ cell development (GO:0007281)5.52140877
36response to pheromone (GO:0019236)5.35864055
37ventricular system development (GO:0021591)5.26369433
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.16601958
39cell recognition (GO:0008037)5.12550671
40regulation of microtubule-based movement (GO:0060632)5.10974213
41spermatid nucleus differentiation (GO:0007289)5.06821225
42centriole replication (GO:0007099)5.04049683
43microtubule severing (GO:0051013)4.99058603
44glycerol ether metabolic process (GO:0006662)4.92660845
45* multicellular organismal reproductive process (GO:0048609)4.92554203
46seminiferous tubule development (GO:0072520)4.87987969
47male meiosis I (GO:0007141)4.76520199
48chromosome organization involved in meiosis (GO:0070192)4.74741343
49regulation of histone H3-K27 methylation (GO:0061085)4.73418919
50regulation of Rab GTPase activity (GO:0032313)4.65185155
51positive regulation of Rab GTPase activity (GO:0032851)4.65185155
52rRNA modification (GO:0000154)4.65153349
53nuclear pore complex assembly (GO:0051292)4.64820566
54centriole assembly (GO:0098534)4.61138007
55ether metabolic process (GO:0018904)4.54986114
56histone H3-K9 demethylation (GO:0033169)4.52931802
57regulation of centriole replication (GO:0046599)4.37575334
58left/right pattern formation (GO:0060972)4.34829489
59DNA methylation involved in gamete generation (GO:0043046)4.31517131
60protein localization to Golgi apparatus (GO:0034067)4.31116552
61sexual reproduction (GO:0019953)4.25175958
62sequestering of actin monomers (GO:0042989)4.24248046
63single strand break repair (GO:0000012)4.19791461
64meiotic nuclear division (GO:0007126)4.14487007
65negative regulation of histone methylation (GO:0031061)4.07500282
66chaperone-mediated protein complex assembly (GO:0051131)4.06499681
67* multicellular organismal development (GO:0007275)3.95506747
68peptidyl-threonine dephosphorylation (GO:0035970)3.83054083
69meiosis I (GO:0007127)3.80009187
70protein polyglutamylation (GO:0018095)3.74465348
71regulation of T-helper 2 cell differentiation (GO:0045628)3.70838739
72genitalia morphogenesis (GO:0035112)3.57053151
73negative regulation of gene expression, epigenetic (GO:0045814)3.56946300
74microtubule nucleation (GO:0007020)3.55705804
75regulation of spindle checkpoint (GO:0090231)3.55623804
76negative regulation of erythrocyte differentiation (GO:0045647)3.52699271
77nuclear pore organization (GO:0006999)3.45769166
78interferon-gamma secretion (GO:0072643)3.41688181
79regulation of ARF GTPase activity (GO:0032312)3.40649660
80DNA conformation change (GO:0071103)3.37595601
81homeostasis of number of cells within a tissue (GO:0048873)3.37411397
82RNA destabilization (GO:0050779)3.30815481
83positive regulation of macrophage activation (GO:0043032)3.29744900
84histone lysine demethylation (GO:0070076)3.28798214
85histone demethylation (GO:0016577)3.28609539
86histone H4 deacetylation (GO:0070933)3.27026962
87negative regulation of Rho protein signal transduction (GO:0035024)3.26495986
88retinoic acid receptor signaling pathway (GO:0048384)3.25275236
89definitive hemopoiesis (GO:0060216)3.24578160
90pore complex assembly (GO:0046931)3.24040550
91microtubule polymerization or depolymerization (GO:0031109)3.22870410
92RNA localization (GO:0006403)3.22672819
93amino-acid betaine transport (GO:0015838)3.22609205
94carnitine transport (GO:0015879)3.22609205
95protein K11-linked deubiquitination (GO:0035871)3.22273699
96protein refolding (GO:0042026)3.21355010
97protein localization to cilium (GO:0061512)3.20972058
98meiotic cell cycle (GO:0051321)3.20147308
99nucleus organization (GO:0006997)3.15980339
100monoubiquitinated protein deubiquitination (GO:0035520)3.13964111
101regulation of somitogenesis (GO:0014807)3.10622946
102multicellular organismal movement (GO:0050879)3.10250918
103musculoskeletal movement (GO:0050881)3.10250918
104mitotic sister chromatid cohesion (GO:0007064)3.06501213
105carnitine transmembrane transport (GO:1902603)3.05118552
106polyamine biosynthetic process (GO:0006596)3.04032946
107glycolytic process (GO:0006096)3.03434100
108regulation of transcription involved in cell fate commitment (GO:0060850)2.98391196
109histone H3-K36 demethylation (GO:0070544)2.97260781
110cellular response to pH (GO:0071467)2.96037397
111protein demethylation (GO:0006482)2.93954692
112protein dealkylation (GO:0008214)2.93954692
113regulation of gamma-delta T cell differentiation (GO:0045586)2.90120784
114Golgi to endosome transport (GO:0006895)2.86661752
115response to acidic pH (GO:0010447)2.85154033
116nucleoside diphosphate phosphorylation (GO:0006165)2.85152943
117histone H3 deacetylation (GO:0070932)2.79706419
118polyol catabolic process (GO:0046174)2.79364901
119cellular ketone body metabolic process (GO:0046950)2.77248720
120chromatin silencing (GO:0006342)2.76848129
121meiotic cell cycle process (GO:1903046)2.75615285
122negative regulation of organelle assembly (GO:1902116)2.75065520
123synapsis (GO:0007129)2.75060348
124response to muramyl dipeptide (GO:0032495)2.74480941
125cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.73249330
126intra-Golgi vesicle-mediated transport (GO:0006891)2.69912730
127protein depolymerization (GO:0051261)2.69903479
128cilium organization (GO:0044782)2.69201975
129alditol metabolic process (GO:0019400)2.69062586
130nucleosome disassembly (GO:0006337)2.68534436
131protein-DNA complex disassembly (GO:0032986)2.68534436
132regulation of cilium assembly (GO:1902017)2.68406345
133axoneme assembly (GO:0035082)2.67496485
134regulation of gamma-delta T cell activation (GO:0046643)2.67244297
135membrane protein intracellular domain proteolysis (GO:0031293)2.67188923
136cilium morphogenesis (GO:0060271)2.62424842
137peptidyl-glutamic acid modification (GO:0018200)2.62227804
138mitochondrion degradation (GO:0000422)2.62101996
139microtubule-based movement (GO:0007018)2.61667965
140cellular component assembly involved in morphogenesis (GO:0010927)2.60862278
141GTP biosynthetic process (GO:0006183)2.60039127
142cilium assembly (GO:0042384)2.56572332
143intraciliary transport (GO:0042073)2.48334102
144lactate metabolic process (GO:0006089)2.37342342
145sperm motility (GO:0030317)14.1249618
146cell wall macromolecule catabolic process (GO:0016998)13.1649638
147cell wall macromolecule metabolic process (GO:0044036)13.1649638
148fusion of sperm to egg plasma membrane (GO:0007342)12.7996520
149acrosome reaction (GO:0007340)12.7394392
150acrosome assembly (GO:0001675)12.0071935
151sperm-egg recognition (GO:0035036)11.8133198
152binding of sperm to zona pellucida (GO:0007339)10.8061835
153cell-cell recognition (GO:0009988)10.5759893
154multicellular organism reproduction (GO:0032504)10.5047996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.15587235
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.65945331
3EZH2_22144423_ChIP-Seq_EOC_Human4.12288262
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.96958587
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95337258
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.91142847
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87381426
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.71397290
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66724510
10GATA1_19941826_ChIP-Seq_K562_Human2.59735878
11VDR_22108803_ChIP-Seq_LS180_Human2.46058879
12MYC_22102868_ChIP-Seq_BL_Human2.40864356
13RUNX_20019798_ChIP-Seq_JUKART_Human2.31706458
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.27929926
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27829971
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27143184
17LXR_22292898_ChIP-Seq_THP-1_Human2.20328010
18TCF7_22412390_ChIP-Seq_EML_Mouse2.19095740
19ZNF274_21170338_ChIP-Seq_K562_Hela2.05240826
20P68_20966046_ChIP-Seq_HELA_Human2.05097067
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.04840596
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03662567
23SPI1_23127762_ChIP-Seq_K562_Human1.99841450
24BCL6_27268052_Chip-Seq_Bcells_Human1.96872064
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94833964
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94023342
27KDM2B_26808549_Chip-Seq_DND41_Human1.89925584
28MAF_26560356_Chip-Seq_TH1_Human1.88586195
29NCOR1_26117541_ChIP-Seq_K562_Human1.87884416
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87412753
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83888890
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81886789
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81122458
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80487281
35SCL_19346495_ChIP-Seq_HPC-7_Human1.80485013
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.79491604
37SMC4_20622854_ChIP-Seq_HELA_Human1.78200827
38MYB_26560356_Chip-Seq_TH2_Human1.77970579
39ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77075037
40* MAF_26560356_Chip-Seq_TH2_Human1.77063617
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76612143
42RAC3_21632823_ChIP-Seq_H3396_Human1.76592835
43E2F1_20622854_ChIP-Seq_HELA_Human1.75183145
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72257524
45STAT1_17558387_ChIP-Seq_HELA_Human1.71977640
46UTX_26944678_Chip-Seq_JUKART_Human1.70857711
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.70060594
48SOX2_22085726_ChIP-Seq_NPCs_Mouse1.69844692
49MYB_26560356_Chip-Seq_TH1_Human1.69842838
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67578704
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67078144
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.65335385
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64727881
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64614196
55MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63896510
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63341253
57GATA2_19941826_ChIP-Seq_K562_Human1.62829079
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.61761949
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.56647838
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55930547
61GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54283912
62ERA_21632823_ChIP-Seq_H3396_Human1.51427082
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50925998
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.50197332
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.49587134
66SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.48823353
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.48452007
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47613895
69P300_27268052_Chip-Seq_Bcells_Human1.47204281
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43077999
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42103402
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41067497
73CBP_20019798_ChIP-Seq_JUKART_Human1.41067497
74KDM2B_26808549_Chip-Seq_REH_Human1.40601140
75TP63_22573176_ChIP-Seq_HFKS_Human1.40413943
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39512288
77VDR_21846776_ChIP-Seq_THP-1_Human1.39165588
78P53_21459846_ChIP-Seq_SAOS-2_Human1.39026897
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37815460
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37403604
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.37206149
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34802474
83CTCF_27219007_Chip-Seq_Bcells_Human1.34511632
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.34332247
85VDR_24763502_ChIP-Seq_THP-1_Human1.34176100
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33646568
87PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30598552
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30593790
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30148462
90REST_21632747_ChIP-Seq_MESCs_Mouse1.30144281
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28746277
92CIITA_25753668_ChIP-Seq_RAJI_Human1.28016374
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.27208700
94SPI1_20517297_ChIP-Seq_HL60_Human1.26984391
95KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26696428
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25621702
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23756732
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23426255
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.23130005
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.22557595
101RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22337306
102GF1_26923725_Chip-Seq_HPCs_Mouse1.21848591
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21407656
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.21193500
105GATA3_27048872_Chip-Seq_THYMUS_Human1.20727525
106* SA1_27219007_Chip-Seq_Bcells_Human1.19657582
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19481337
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19051380
109RUNX1_27514584_Chip-Seq_MCF-7_Human1.18782033
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.18388285
111GATA1_19941827_ChIP-Seq_MEL_Mouse1.17803224
112CTCF_21964334_Chip-Seq_Bcells_Human1.17420179
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17162906
114SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17138621
115SPI1_26923725_Chip-Seq_HPCs_Mouse1.17033798
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16022126
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15873002
118DROSHA_22980978_ChIP-Seq_HELA_Human1.15751160
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15658358
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14944783
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14740323
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14259310
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14259310
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13945750
125OCT4_20526341_ChIP-Seq_ESCs_Human1.13098090
126CEBPB_22108803_ChIP-Seq_LS180_Human1.12520109
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12371359
128MYC_27129775_Chip-Seq_CORNEA_Mouse1.12055675
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.11574875
130ELK3_25401928_ChIP-Seq_HUVEC_Human1.10763663
131ERG_20517297_ChIP-Seq_VCAP_Human1.10599308
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10514143
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10315984
134RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09709788
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09016933
136TAF2_19829295_ChIP-Seq_ESCs_Human1.08958830
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08870382
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08459593
139VDR_24787735_ChIP-Seq_THP-1_Human1.08128610
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08096615
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07693796
142GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07237323
143YY1_22570637_ChIP-Seq_MALME-3M_Human1.07058687
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06497266
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06460017
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.06081230
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05711101
148ESET_19884257_ChIP-Seq_ESCs_Mouse1.05656765
149FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05498030
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05031455
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04049419
152KDM2B_26808549_Chip-Seq_K562_Human1.03476945
153SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03317265
154CTCF_20526341_ChIP-Seq_ESCs_Human1.02815577
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02570619
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02399377
157FOXM1_23109430_ChIP-Seq_U2OS_Human1.02127877
158CRX_20693478_ChIP-Seq_RETINA_Mouse1.01662519
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01512850
160NANOG_18555785_Chip-Seq_ESCs_Mouse1.01278788
161ELF1_20517297_ChIP-Seq_JURKAT_Human1.00809811
162OCT4_19829295_ChIP-Seq_ESCs_Human1.00646513
163SOX11_22085726_ChIP-Seq_ESNs_Mouse1.00173578
164CREB1_26743006_Chip-Seq_LNCaP_Human0.98835441
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98416581
166LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97941016
167NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97611517
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97170815
169SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95838579
170BCOR_27268052_Chip-Seq_Bcells_Human0.93215554
171OCT4_18555785_Chip-Seq_ESCs_Mouse0.92812671
172FLI1_21867929_ChIP-Seq_CD8_Mouse0.92584486
173KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91596574
174SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91022439
175P53_22387025_ChIP-Seq_ESCs_Mouse0.90276179
176OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87870041
177SOX2_21211035_ChIP-Seq_LN229_Human0.87519928
178PHF8_20622854_ChIP-Seq_HELA_Human0.87063720
179TAF15_26573619_Chip-Seq_HEK293_Human0.86930324
180PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86656040
181NANOG_20526341_ChIP-Seq_ESCs_Human0.86474547
182CMYC_18555785_Chip-Seq_ESCs_Mouse0.85881400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03595417
2MP0001929_abnormal_gametogenesis5.50921308
3MP0008877_abnormal_DNA_methylation3.71917478
4MP0002210_abnormal_sex_determination3.28074750
5MP0002161_abnormal_fertility/fecundity3.27803293
6MP0001348_abnormal_lacrimal_gland3.23283077
7MP0002132_abnormal_respiratory_system3.14785774
8MP0005451_abnormal_body_composition3.10018348
9MP0005670_abnormal_white_adipose2.90356665
10MP0001145_abnormal_male_reproductive2.81165358
11MP0000653_abnormal_sex_gland2.42678207
12MP0003172_abnormal_lysosome_physiology2.40121032
13MP0002653_abnormal_ependyma_morphology2.22685734
14MP0003436_decreased_susceptibility_to2.21304971
15MP0000678_abnormal_parathyroid_gland2.20042003
16MP0003656_abnormal_erythrocyte_physiolo2.09446545
17MP0005083_abnormal_biliary_tract2.04912721
18MP0005410_abnormal_fertilization16.7818193
19MP0005310_abnormal_salivary_gland1.88821810
20MP0003646_muscle_fatigue1.80302991
21MP0002160_abnormal_reproductive_system1.69678376
22MP0002138_abnormal_hepatobiliary_system1.56055744
23MP0004233_abnormal_muscle_weight1.47569087
24MP0000703_abnormal_thymus_morphology1.38758838
25MP0001835_abnormal_antigen_presentation1.31294922
26MP0003763_abnormal_thymus_physiology1.29902430
27MP0002398_abnormal_bone_marrow1.26546973
28MP0002009_preneoplasia1.25874618
29MP0005623_abnormal_meninges_morphology1.25575002
30MP0002249_abnormal_larynx_morphology1.24872180
31MP0003077_abnormal_cell_cycle1.19566966
32MP0004510_myositis1.17529385
33MP0004947_skin_inflammation1.15995971
34MP0002722_abnormal_immune_system1.14184367
35MP0001873_stomach_inflammation1.13196591
36MP0002419_abnormal_innate_immunity1.12271858
37MP0002723_abnormal_immune_serum1.07306295
38MP0001800_abnormal_humoral_immune1.06453002
39MP0002282_abnormal_trachea_morphology1.03820446
40MP0001765_abnormal_ion_homeostasis1.03284941
41MP0003718_maternal_effect1.02996262
42MP0005379_endocrine/exocrine_gland_phen1.01540404
43MP0005076_abnormal_cell_differentiation1.01259245
44MP0003300_gastrointestinal_ulcer1.00072345
45MP0002396_abnormal_hematopoietic_system0.99734853
46MP0001984_abnormal_olfaction0.99106744
47MP0003303_peritoneal_inflammation0.98057662
48MP0005464_abnormal_platelet_physiology0.95124497
49MP0005000_abnormal_immune_tolerance0.93339687
50MP0005025_abnormal_response_to0.91549326
51MP0002420_abnormal_adaptive_immunity0.91204336
52MP0002166_altered_tumor_susceptibility0.89861161
53MP0000716_abnormal_immune_system0.89709764
54MP0001819_abnormal_immune_cell0.89003693
55MP0002429_abnormal_blood_cell0.88689243
56MP0000689_abnormal_spleen_morphology0.88258845
57MP0000609_abnormal_liver_physiology0.85803712
58MP0002452_abnormal_antigen_presenting0.84528189
59MP0005389_reproductive_system_phenotype0.84218014
60MP0000681_abnormal_thyroid_gland0.84111288
61MP0002234_abnormal_pharynx_morphology0.80977025
62MP0008058_abnormal_DNA_repair0.80426194
63MP0005647_abnormal_sex_gland0.80413530
64MP0000685_abnormal_immune_system0.77396491
65MP0000003_abnormal_adipose_tissue0.76371159
66MP0009046_muscle_twitch0.75523525
67MP0003115_abnormal_respiratory_system0.75249035
68MP0003828_pulmonary_edema0.75246871
69MP0001533_abnormal_skeleton_physiology0.74116329
70MP0003011_delayed_dark_adaptation0.73738983
71MP0008995_early_reproductive_senescence0.73491945
72MP0002822_catalepsy0.72869604
73MP0009333_abnormal_splenocyte_physiolog0.71228590
74MP0009765_abnormal_xenobiotic_induced0.70473393
75MP0002127_abnormal_cardiovascular_syste0.68846414
76MP0002933_joint_inflammation0.66794984
77MP0005535_abnormal_body_temperature0.64212290
78MP0002970_abnormal_white_adipose0.63678645
79MP0010329_abnormal_lipoprotein_level0.61288505
80MP0004957_abnormal_blastocyst_morpholog0.61145463
81MP0005377_hearing/vestibular/ear_phenot0.60956832
82MP0003878_abnormal_ear_physiology0.60956832
83MP0008469_abnormal_protein_level0.60178261
84MP0003724_increased_susceptibility_to0.59803366
85MP0005636_abnormal_mineral_homeostasis0.57665353
86MP0003329_amyloid_beta_deposits0.57397036
87MP0005666_abnormal_adipose_tissue0.57111035
88MP0009697_abnormal_copulation0.55864702
89MP0000598_abnormal_liver_morphology0.55405513
90MP0009278_abnormal_bone_marrow0.55199158
91MP0005248_abnormal_Harderian_gland0.55026724
92MP0003091_abnormal_cell_migration0.54787957
93MP0009764_decreased_sensitivity_to0.54116522
94MP0000249_abnormal_blood_vessel0.53322386
95MP0002998_abnormal_bone_remodeling0.52995504
96MP0001545_abnormal_hematopoietic_system0.51444973
97MP0005397_hematopoietic_system_phenotyp0.51444973
98MP0004036_abnormal_muscle_relaxation0.50255322
99MP0001851_eye_inflammation0.49088897
100MP0005334_abnormal_fat_pad0.48647585
101MP0002080_prenatal_lethality0.48591288
102MP0006036_abnormal_mitochondrial_physio0.47845882
103MP0003699_abnormal_female_reproductive0.47683972
104MP0000569_abnormal_digit_pigmentation0.46938796
105MP0000358_abnormal_cell_content/0.46632735
106MP0001324_abnormal_eye_pigmentation0.45033039
107MP0000534_abnormal_ureter_morphology0.44319223
108MP0001764_abnormal_homeostasis0.43929648
109MP0002269_muscular_atrophy0.43003098
110MP0010094_abnormal_chromosome_stability0.42432196
111MP0001293_anophthalmia0.40340333
112MP0002928_abnormal_bile_duct0.38544517
113MP0004133_heterotaxia0.37627833
114MP0003111_abnormal_nucleus_morphology0.37465184
115MP0002736_abnormal_nociception_after0.36585788
116MP0005253_abnormal_eye_physiology0.34447659
117MP0003950_abnormal_plasma_membrane0.34000107
118MP0009115_abnormal_fat_cell0.33992832
119MP0005551_abnormal_eye_electrophysiolog0.33004584
120MP0000604_amyloidosis0.29899858
121MP0003942_abnormal_urinary_system0.29805132
122MP0004811_abnormal_neuron_physiology0.29772067
123MP0003633_abnormal_nervous_system0.29331069
124MP0005391_vision/eye_phenotype0.28746275
125MP0003861_abnormal_nervous_system0.25317306
126MP0002169_no_abnormal_phenotype0.25123259
127MP0004742_abnormal_vestibular_system0.25091582
128MP0002873_normal_phenotype0.24934797
129MP0001730_embryonic_growth_arrest0.24660462
130MP0003948_abnormal_gas_homeostasis0.24466345
131MP0003631_nervous_system_phenotype0.24319960
132MP0002139_abnormal_hepatobiliary_system0.24116391
133MP0002971_abnormal_brown_adipose0.23791929
134MP0006035_abnormal_mitochondrial_morpho0.23641443
135MP0003787_abnormal_imprinting0.23518351
136MP0002152_abnormal_brain_morphology0.22817312
137MP0002295_abnormal_pulmonary_circulatio0.22189149
138MP0001119_abnormal_female_reproductive0.22095279
139MP0001661_extended_life_span0.21749238
140MP0002102_abnormal_ear_morphology0.21446366
141MP0003879_abnormal_hair_cell0.21286131
142MP0004019_abnormal_vitamin_homeostasis0.21193939
143MP0003786_premature_aging0.20025424
144MP0001968_abnormal_touch/_nociception0.18551046
145MP0002092_abnormal_eye_morphology0.17981288
146MP0010307_abnormal_tumor_latency0.17814006
147MP0005375_adipose_tissue_phenotype0.17550417
148MP0004270_analgesia0.17425733
149MP0001849_ear_inflammation0.17380507
150MP0008057_abnormal_DNA_replication0.16837883
151MP0008961_abnormal_basal_metabolism0.16833664
152MP0003959_abnormal_lean_body0.16590522
153MP0000313_abnormal_cell_death0.16256659
154MP0008007_abnormal_cellular_replicative0.16149905
155MP0000751_myopathy0.15942487
156MP0000001_mammalian_phenotype0.15372482
157MP0002084_abnormal_developmental_patter0.14737223
158MP0005503_abnormal_tendon_morphology0.14374313
159MP0004043_abnormal_pH_regulation0.14070653
160MP0002229_neurodegeneration0.13776340
161MP0001727_abnormal_embryo_implantation0.13060891
162MP0004808_abnormal_hematopoietic_stem0.12839109
163MP0000920_abnormal_myelination0.12445998
164MP0003936_abnormal_reproductive_system0.12347087
165MP0001986_abnormal_taste_sensitivity0.12122739
166MP0003045_fibrosis0.11956261
167MP0002405_respiratory_system_inflammati0.11503797

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.31544105
2Abnormal respiratory epithelium morphology (HP:0012253)9.01827588
3Abnormal respiratory motile cilium morphology (HP:0005938)9.01827588
4Rhinitis (HP:0012384)7.53834251
5Chronic bronchitis (HP:0004469)7.39503384
6Abnormal ciliary motility (HP:0012262)7.16723718
7Infertility (HP:0000789)7.07863750
8Severe visual impairment (HP:0001141)6.49324116
9Nasal polyposis (HP:0100582)6.47290266
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.39331904
11Abnormality of the nasal mucosa (HP:0000433)5.31755114
12Male infertility (HP:0003251)4.91063253
13Bronchitis (HP:0012387)4.59604141
14Bronchiectasis (HP:0002110)4.43246461
15Nephronophthisis (HP:0000090)4.30476855
16Abnormal spermatogenesis (HP:0008669)3.88830095
17Chronic hepatic failure (HP:0100626)3.68988208
18Hyperkalemia (HP:0002153)3.66445106
19Attenuation of retinal blood vessels (HP:0007843)3.62768885
20Aplasia/Hypoplasia of the earlobes (HP:0009906)3.56791444
21Bony spicule pigmentary retinopathy (HP:0007737)3.39294313
22Recurrent otitis media (HP:0000403)3.32087861
23Abnormality of the renal medulla (HP:0100957)3.23520081
24Abnormality of the fingertips (HP:0001211)3.22422093
25Recurrent sinusitis (HP:0011108)3.21039485
26Resting tremor (HP:0002322)3.16299152
27Cone-rod dystrophy (HP:0000548)3.10353352
28Hypoplasia of the thymus (HP:0000778)3.08315435
29Truncal obesity (HP:0001956)3.04108618
30Reticulocytosis (HP:0001923)3.03128212
31Poikilocytosis (HP:0004447)2.95560043
32Hypoalphalipoproteinemia (HP:0003233)2.89305383
33Impulsivity (HP:0100710)2.82078774
34Hypochromic microcytic anemia (HP:0004840)2.77123826
35Recurrent bronchitis (HP:0002837)2.73004646
36Tubulointerstitial nephritis (HP:0001970)2.70803738
37Tubular atrophy (HP:0000092)2.70802887
38Menstrual irregularities (HP:0000858)2.70287476
39Potter facies (HP:0002009)2.67490347
40Facial shape deformation (HP:0011334)2.67490347
41Abnormality of dental color (HP:0011073)2.66943411
42Gastrointestinal infarctions (HP:0005244)2.66300707
43Cholecystitis (HP:0001082)2.63568504
44Abnormal gallbladder physiology (HP:0012438)2.63568504
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.60634775
46Molar tooth sign on MRI (HP:0002419)2.58804945
47Abnormality of midbrain morphology (HP:0002418)2.58804945
48Bowel incontinence (HP:0002607)2.53714831
49Azoospermia (HP:0000027)2.53202719
50Seborrheic dermatitis (HP:0001051)2.52503496
51Tubulointerstitial abnormality (HP:0001969)2.52174884
52Abnormal rod and cone electroretinograms (HP:0008323)2.52084875
53Increased IgE level (HP:0003212)2.49895225
54Progressive sensorineural hearing impairment (HP:0000408)2.49066994
55Postural instability (HP:0002172)2.48318650
56Broad face (HP:0000283)2.48296534
57Polycythemia (HP:0001901)2.45515822
58Supernumerary ribs (HP:0005815)2.40078829
59Aplasia/Hypoplasia of the thymus (HP:0010515)2.39542917
60Slow saccadic eye movements (HP:0000514)2.38154948
61Prolonged bleeding time (HP:0003010)2.37510670
62Abnormality of the aortic arch (HP:0012303)2.36887378
63Gonadotropin excess (HP:0000837)2.36429579
64Sandal gap (HP:0001852)2.35546032
65Hyperthyroidism (HP:0000836)2.34414217
66Hypochromic anemia (HP:0001931)2.34321604
67Medial flaring of the eyebrow (HP:0010747)2.34160338
68Type I diabetes mellitus (HP:0100651)2.33016624
69Amelogenesis imperfecta (HP:0000705)2.32823473
70Gingivitis (HP:0000230)2.32198193
71Acanthocytosis (HP:0001927)2.32003783
72Abnormal large intestine physiology (HP:0012700)2.31529247
73Dyschromatopsia (HP:0007641)2.31487026
74Progressive hearing impairment (HP:0001730)2.31220320
75Hypoparathyroidism (HP:0000829)2.25194635
76Choroideremia (HP:0001139)2.24737960
77Chronic obstructive pulmonary disease (HP:0006510)2.20057026
78Obstructive lung disease (HP:0006536)2.20057026
79Tubulointerstitial fibrosis (HP:0005576)2.19694751
80Abnormality of the costochondral junction (HP:0000919)2.18740405
81Hypertriglyceridemia (HP:0002155)2.17271339
82Enlarged epiphyses (HP:0010580)2.15911575
83Obsessive-compulsive behavior (HP:0000722)2.14311029
84Peripheral hypomyelination (HP:0007182)2.12295041
85Decreased central vision (HP:0007663)2.12148218
86Hepatitis (HP:0012115)2.12039148
87Abnormality of macular pigmentation (HP:0008002)2.10891354
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10456391
89Hypoplastic ischia (HP:0003175)2.09033890
90Truncus arteriosus (HP:0001660)2.08832596
91Fatigue (HP:0012378)2.03406356
92Hypertensive crisis (HP:0100735)2.02681182
93Acute myeloid leukemia (HP:0004808)2.02373943
94Colitis (HP:0002583)2.01291538
95Renovascular hypertension (HP:0100817)2.00021995
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1962352
97Dynein arm defect of respiratory motile cilia (HP:0012255)13.1101799
98Absent/shortened dynein arms (HP:0200106)13.1101799
99Spastic tetraparesis (HP:0001285)1.99944902
100Atelectasis (HP:0100750)1.99408399
101Supernumerary bones of the axial skeleton (HP:0009144)1.98952832
102Cholelithiasis (HP:0001081)1.98324051
103Osteomalacia (HP:0002749)1.95556898
104Insulin-resistant diabetes mellitus (HP:0000831)1.95184566
105Polydipsia (HP:0001959)1.92923266
106Abnormal drinking behavior (HP:0030082)1.92923266
107Neoplasm of the heart (HP:0100544)1.92536133
108Acute hepatic failure (HP:0006554)1.91586130
109Portal hypertension (HP:0001409)1.90197310
110Abnormality of the thymus (HP:0000777)1.88651361
111Hemorrhage of the eye (HP:0011885)1.86322157
112Eczematoid dermatitis (HP:0000976)1.85329736
113Stage 5 chronic kidney disease (HP:0003774)1.84958565
114Flattened epiphyses (HP:0003071)1.84601701
115Double outlet right ventricle (HP:0001719)1.83147909
116Congenital malformation of the right heart (HP:0011723)1.83147909
117Abnormality of lateral ventricle (HP:0030047)1.81687933
118Upper limb muscle weakness (HP:0003484)1.80677611
119Abnormality of the hepatic vasculature (HP:0006707)1.78187530
120Convex nasal ridge (HP:0000444)1.77613488
121Postaxial foot polydactyly (HP:0001830)1.77591166
122Widely patent fontanelles and sutures (HP:0004492)1.77184661
123Congenital hepatic fibrosis (HP:0002612)1.77120877
124Abnormality of the renal cortex (HP:0011035)1.74705432
125Heterotopia (HP:0002282)1.74673706
126Abnormality of dentin (HP:0010299)1.74520887
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72579013
128Hyponatremia (HP:0002902)1.72498452
129Recurrent pneumonia (HP:0006532)1.70896861
130Abnormality of renal excretion (HP:0011036)1.70563313
131Hypophosphatemic rickets (HP:0004912)1.69523038
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67073890
133Neurofibrillary tangles (HP:0002185)1.64667016
134Short ribs (HP:0000773)1.59201993
135Bell-shaped thorax (HP:0001591)1.56114285
136Bile duct proliferation (HP:0001408)1.53692417
137Abnormal biliary tract physiology (HP:0012439)1.53692417
138Abnormality of the dental pulp (HP:0006479)1.52549623
139Renal dysplasia (HP:0000110)1.52147645
140Aplasia/Hypoplasia of the lens (HP:0008063)1.51248200
141Oculomotor apraxia (HP:0000657)1.47823278
142Abnormal urine output (HP:0012590)1.47787791
143Abnormality of the lower motor neuron (HP:0002366)1.39424538
144Asymmetric septal hypertrophy (HP:0001670)1.38431420
145Abnormality of the dental root (HP:0006486)1.38246164
146Taurodontia (HP:0000679)1.38246164
147Abnormality of permanent molar morphology (HP:0011071)1.38246164
148Fibular hypoplasia (HP:0003038)1.37252114
149Postaxial hand polydactyly (HP:0001162)1.36126682
150Deformed sella turcica (HP:0002681)1.35002561
151Bundle branch block (HP:0011710)1.34842328
152Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.34687924
153Absent epiphyses (HP:0010577)1.34687924
154Cerebral inclusion bodies (HP:0100314)1.33925212
155Easy fatigability (HP:0003388)1.33475468
156Loss of speech (HP:0002371)1.33062784
157Exercise-induced myalgia (HP:0003738)1.30908075
158Myoglobinuria (HP:0002913)1.30797716
159Cystic liver disease (HP:0006706)1.28979291
160Sensory axonal neuropathy (HP:0003390)1.28917771
161Abnormality of molar morphology (HP:0011070)1.27236988
162Abnormality of molar (HP:0011077)1.27236988
163Facial cleft (HP:0002006)1.26438272
164Hypercholesterolemia (HP:0003124)1.25975487
165Fatigable weakness (HP:0003473)1.24657390
166Abnormality of the neuromuscular junction (HP:0003398)1.24657390
167Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.24463113
168Nephropathy (HP:0000112)1.23370576
169Polyuria (HP:0000103)1.23368908
170Hemiparesis (HP:0001269)1.23304178
171Amyotrophic lateral sclerosis (HP:0007354)1.23158049
172Absent frontal sinuses (HP:0002688)1.21546258
173Short femoral neck (HP:0100864)1.19503688
174Chronic sinusitis (HP:0011109)1.18888970
175Abnormality of saccadic eye movements (HP:0000570)1.18161123
176Cerebellar dysplasia (HP:0007033)1.17527841
177Constricted visual fields (HP:0001133)1.17118206
178Short thorax (HP:0010306)1.16528405
179Rhabdomyolysis (HP:0003201)1.15473244
180Pancreatic fibrosis (HP:0100732)1.13494588
181Impaired proprioception (HP:0010831)1.12511249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.53440373
2PDK37.53440373
3TESK17.36415122
4PRKD35.56397520
5ICK4.89835671
6PDK24.84698436
7BRD43.78649544
8CDK123.53955481
9PTK2B2.42651767
10WNK42.28560210
11STK382.19767564
12DDR22.17283972
13STK392.09777159
14INSRR2.07939576
15KSR22.00240404
16PLK21.78070690
17NEK21.77795351
18TRIB31.76155481
19PRPF4B1.72601763
20SIK21.68548702
21CAMK1D1.67928012
22MAP2K31.65194474
23DYRK1B1.64365066
24PNCK1.62396367
25MAP3K21.54485470
26PIK3CG1.52863306
27ERN11.51098961
28MAP4K11.35191904
29CDK71.22818354
30FGFR31.20503902
31GRK61.15626511
32JAK31.11724537
33FGFR41.08831338
34BLK1.04756046
35DYRK31.02164590
36MAP3K141.02032121
37MAP2K21.01670705
38AKT31.00991649
39TNK20.95778357
40WNK10.91651375
41TYRO30.90382768
42TYK20.87473535
43MAP3K70.86035712
44SIK10.84792985
45MAPK150.84521675
46PRKAA20.80357969
47IRAK40.77524198
48EEF2K0.77330712
49MAP3K80.74071939
50BTK0.73377414
51RIPK40.72651106
52SIK30.72565473
53MAP4K20.72407509
54IRAK10.71264830
55PASK0.70897765
56TAOK30.70880524
57PINK10.70734726
58UHMK10.69457180
59SYK0.67223134
60STK30.65462471
61MAP3K130.63822569
62MAPK110.63655096
63JAK20.63631947
64YES10.62653993
65TTK0.62495646
66MAP3K110.62227087
67CHEK20.62082346
68TESK20.61015368
69HCK0.60905322
70RPS6KL10.59781126
71RPS6KC10.59781126
72CCNB10.58871891
73MAPK10.54734322
74CAMK40.53016352
75MUSK0.52968205
76* PDPK10.52089621
77IKBKE0.51707431
78NTRK20.51180391
79RPS6KA20.50749272
80MAP2K60.49578705
81ITK0.49241783
82CDK30.48203583
83RET0.47402347
84HIPK20.46009082
85* PDK10.45552717
86CAMK1G0.44790269
87IKBKB0.44712812
88IRAK20.44220340
89RPS6KA60.44081723
90SGK10.43876683
91MAP3K30.43704604
92MAP3K60.43592230
93PAK10.42709159
94EIF2AK10.41929506
95LMTK20.41826714
96TBK10.41142187
97LCK0.40002706
98STK38L0.39479626
99KIT0.39213225
100SGK30.39054015
101MAPKAPK50.38953348
102PRKCG0.38363864
103CSK0.38097974
104MAP3K100.37939449
105CHEK10.37583991
106MAPK100.36986218
107TEC0.36600672
108PAK20.31711867
109MARK20.31645497
110MTOR0.29390449
111NEK60.28861741
112ATM0.27823763
113PAK40.25548266
114ATR0.24907405
115CAMKK10.24296213
116PRKAA10.21579626
117PRKCZ0.20939184
118RPS6KB10.18530690
119PRKCQ0.16900938
120BRSK20.16662570
121EPHB10.16188160
122STK100.14537791
123CDK150.14397964
124CDC70.13109418
125RPS6KA10.13086227
126WEE10.12913789
127CDK180.11441843
128CSF1R0.11218647
129CDK11A0.11154648
130PKN10.10702315
131PIM10.10464736
132BRAF0.10378333
133PLK10.10205037
134BRSK10.10194047
135MARK30.08708632
136STK110.08226654
137GSK3B0.07916982
138CLK10.07858973
139CDK140.06722355
140CSNK2A10.06587135
141PRKG20.06554302
142CDK60.05164503
143PRKCD0.04396846
144MAPK80.03935534
145CAMK2A0.03924565
146PLK40.03675944
147WNK30.03550476
148PRKACG0.03430704
149CDK20.03302101
150CDK40.03029389
151CDK10.02932882
152AURKA0.02385936
153RIPK10.02095724
154PRKG10.02053948
155CSNK1D0.01943016
156PRKCB0.01868650
157PRKCA0.01088740
158ZAP700.00292317
159PRKACA-0.0377154
160PDGFRB-0.0374762
161MAP3K1-0.0356714
162PRKDC-0.0313546
163MAP3K5-0.0295869
164RPS6KA3-0.0266732
165EGFR-0.0249618
166PAK6-0.0098417
167CSNK2A2-0.0021361

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.83621850
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.27157728
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.53707331
4Vitamin B6 metabolism_Homo sapiens_hsa007503.50976649
5Linoleic acid metabolism_Homo sapiens_hsa005913.45089938
6Pyruvate metabolism_Homo sapiens_hsa006203.24553096
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.68250127
8Glucagon signaling pathway_Homo sapiens_hsa049222.53319183
9Acute myeloid leukemia_Homo sapiens_hsa052212.51525326
10Propanoate metabolism_Homo sapiens_hsa006402.41185627
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38626738
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38168231
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30529474
14Basal transcription factors_Homo sapiens_hsa030222.15606751
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97004155
16Glycerolipid metabolism_Homo sapiens_hsa005611.96424390
17PPAR signaling pathway_Homo sapiens_hsa033201.92746927
18Olfactory transduction_Homo sapiens_hsa047401.88537028
19Selenocompound metabolism_Homo sapiens_hsa004501.87868133
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.85789932
21Non-small cell lung cancer_Homo sapiens_hsa052231.82795503
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77885391
23Fat digestion and absorption_Homo sapiens_hsa049751.74796489
24Influenza A_Homo sapiens_hsa051641.71231684
25Ether lipid metabolism_Homo sapiens_hsa005651.69239453
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.64004743
27Amphetamine addiction_Homo sapiens_hsa050311.59777241
28Pentose phosphate pathway_Homo sapiens_hsa000301.59531815
29Fructose and mannose metabolism_Homo sapiens_hsa000511.57477789
30Osteoclast differentiation_Homo sapiens_hsa043801.55923552
31T cell receptor signaling pathway_Homo sapiens_hsa046601.54403882
32Oocyte meiosis_Homo sapiens_hsa041141.54017617
33mTOR signaling pathway_Homo sapiens_hsa041501.53200435
34Chronic myeloid leukemia_Homo sapiens_hsa052201.49722034
35Mineral absorption_Homo sapiens_hsa049781.49061172
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48579856
37Fatty acid metabolism_Homo sapiens_hsa012121.46153238
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45752745
39Fatty acid degradation_Homo sapiens_hsa000711.45344840
40Herpes simplex infection_Homo sapiens_hsa051681.38639766
41Dorso-ventral axis formation_Homo sapiens_hsa043201.37088638
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36675374
43Leishmaniasis_Homo sapiens_hsa051401.35860795
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.32409684
45Measles_Homo sapiens_hsa051621.31506638
46Cardiac muscle contraction_Homo sapiens_hsa042601.28919325
47Fanconi anemia pathway_Homo sapiens_hsa034601.28467246
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26503265
49Allograft rejection_Homo sapiens_hsa053301.25095217
50Carbon metabolism_Homo sapiens_hsa012001.23824506
51Autoimmune thyroid disease_Homo sapiens_hsa053201.22681977
52Graft-versus-host disease_Homo sapiens_hsa053321.22582132
53Pancreatic cancer_Homo sapiens_hsa052121.20481850
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.17803375
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16950263
56Hepatitis B_Homo sapiens_hsa051611.15465554
57Prolactin signaling pathway_Homo sapiens_hsa049171.15365693
58Other glycan degradation_Homo sapiens_hsa005111.14500378
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.08985110
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08838753
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08524426
62Glutathione metabolism_Homo sapiens_hsa004801.07062083
63Renin secretion_Homo sapiens_hsa049241.06687581
64Toxoplasmosis_Homo sapiens_hsa051451.04700495
65Type I diabetes mellitus_Homo sapiens_hsa049401.03842548
66Choline metabolism in cancer_Homo sapiens_hsa052311.03706015
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03336002
68Prostate cancer_Homo sapiens_hsa052151.01237363
69FoxO signaling pathway_Homo sapiens_hsa040681.00652155
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98520060
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98172049
72Antigen processing and presentation_Homo sapiens_hsa046120.96175952
73Arachidonic acid metabolism_Homo sapiens_hsa005900.94524812
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.93300250
75mRNA surveillance pathway_Homo sapiens_hsa030150.92891797
76Viral myocarditis_Homo sapiens_hsa054160.92601390
77Purine metabolism_Homo sapiens_hsa002300.91286663
78Hedgehog signaling pathway_Homo sapiens_hsa043400.90316962
79Lysine degradation_Homo sapiens_hsa003100.89729008
80Systemic lupus erythematosus_Homo sapiens_hsa053220.89199899
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88719558
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88555188
83Notch signaling pathway_Homo sapiens_hsa043300.87171893
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.86836984
85Collecting duct acid secretion_Homo sapiens_hsa049660.85956616
86Endometrial cancer_Homo sapiens_hsa052130.85488109
87Insulin secretion_Homo sapiens_hsa049110.83061457
88Huntingtons disease_Homo sapiens_hsa050160.81014937
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80431942
90ErbB signaling pathway_Homo sapiens_hsa040120.75893380
91Platelet activation_Homo sapiens_hsa046110.75795540
92Insulin signaling pathway_Homo sapiens_hsa049100.75051807
93Estrogen signaling pathway_Homo sapiens_hsa049150.74880982
94Bile secretion_Homo sapiens_hsa049760.74787319
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74764496
96Epstein-Barr virus infection_Homo sapiens_hsa051690.74744114
97Long-term potentiation_Homo sapiens_hsa047200.74196849
98Chemokine signaling pathway_Homo sapiens_hsa040620.73217628
99MAPK signaling pathway_Homo sapiens_hsa040100.73131843
100Tuberculosis_Homo sapiens_hsa051520.72882332
101Biosynthesis of amino acids_Homo sapiens_hsa012300.72738116
102Chemical carcinogenesis_Homo sapiens_hsa052040.72514408
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71699075
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.71479881
105Thyroid hormone synthesis_Homo sapiens_hsa049180.69745250
106TNF signaling pathway_Homo sapiens_hsa046680.69158672
107Renal cell carcinoma_Homo sapiens_hsa052110.67987205
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.64649949
109Renin-angiotensin system_Homo sapiens_hsa046140.64129754
110Thyroid cancer_Homo sapiens_hsa052160.63793368
111RNA transport_Homo sapiens_hsa030130.63660193
112Colorectal cancer_Homo sapiens_hsa052100.61704025
113ABC transporters_Homo sapiens_hsa020100.60724163
114Pancreatic secretion_Homo sapiens_hsa049720.59885771
115Staphylococcus aureus infection_Homo sapiens_hsa051500.59883101
116Glioma_Homo sapiens_hsa052140.58736467
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58581687
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57512393
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.57143891
120Arginine biosynthesis_Homo sapiens_hsa002200.56316774
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.56171754
122Primary immunodeficiency_Homo sapiens_hsa053400.55689739
123Butanoate metabolism_Homo sapiens_hsa006500.55638964
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54503682
125HTLV-I infection_Homo sapiens_hsa051660.54465316
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53781818
127AMPK signaling pathway_Homo sapiens_hsa041520.52885288
128Alcoholism_Homo sapiens_hsa050340.52335524
129Salivary secretion_Homo sapiens_hsa049700.51910251
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49493353
131Apoptosis_Homo sapiens_hsa042100.49363327
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49278019
133Calcium signaling pathway_Homo sapiens_hsa040200.48891234
134MicroRNAs in cancer_Homo sapiens_hsa052060.48848257
135Phenylalanine metabolism_Homo sapiens_hsa003600.48802283
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.48313867
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47897982
138Circadian rhythm_Homo sapiens_hsa047100.47482702
139Legionellosis_Homo sapiens_hsa051340.46904951
140Endocytosis_Homo sapiens_hsa041440.45306824
141Protein digestion and absorption_Homo sapiens_hsa049740.43163143
142Hepatitis C_Homo sapiens_hsa051600.42729290
143VEGF signaling pathway_Homo sapiens_hsa043700.39144450
144Gastric acid secretion_Homo sapiens_hsa049710.38604856
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37837821
146Synaptic vesicle cycle_Homo sapiens_hsa047210.37466025
147Inositol phosphate metabolism_Homo sapiens_hsa005620.35660701
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34889417
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34448913
150Metabolic pathways_Homo sapiens_hsa011000.33509766
151Cocaine addiction_Homo sapiens_hsa050300.31232339
152Taste transduction_Homo sapiens_hsa047420.30856229
153cAMP signaling pathway_Homo sapiens_hsa040240.30558332
154Sulfur metabolism_Homo sapiens_hsa009200.29289729
155Circadian entrainment_Homo sapiens_hsa047130.20181448
156Pyrimidine metabolism_Homo sapiens_hsa002400.19999930
157B cell receptor signaling pathway_Homo sapiens_hsa046620.19559225
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17569477
159Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16669011
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14150168
161Viral carcinogenesis_Homo sapiens_hsa052030.12399637
162Type II diabetes mellitus_Homo sapiens_hsa049300.12069467
163HIF-1 signaling pathway_Homo sapiens_hsa040660.09328379
164Insulin resistance_Homo sapiens_hsa049310.08877414
165Wnt signaling pathway_Homo sapiens_hsa043100.07697518
166Salmonella infection_Homo sapiens_hsa051320.07245562
167Basal cell carcinoma_Homo sapiens_hsa052170.03852332

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