TSSK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.83998063
2epithelial cilium movement (GO:0003351)9.76323769
3axonemal dynein complex assembly (GO:0070286)9.74906955
4spermatid development (GO:0007286)9.62016018
5reproduction (GO:0000003)9.24808207
6motile cilium assembly (GO:0044458)9.18776810
7regulation of cilium movement (GO:0003352)8.57145397
8cilium or flagellum-dependent cell motility (GO:0001539)8.41535677
9cilium movement (GO:0003341)7.89413642
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45961232
11single fertilization (GO:0007338)7.35417548
12sperm capacitation (GO:0048240)6.99208238
13synaptonemal complex organization (GO:0070193)6.89162986
14male meiosis (GO:0007140)6.79285358
15negative regulation of inclusion body assembly (GO:0090084)6.77905938
16synaptonemal complex assembly (GO:0007130)6.75538820
17piRNA metabolic process (GO:0034587)6.59973609
18* spermatogenesis (GO:0007283)6.54591929
19* male gamete generation (GO:0048232)6.52266298
20microtubule depolymerization (GO:0007019)6.41578203
21organic cation transport (GO:0015695)6.37705447
22fertilization (GO:0009566)6.23116995
23* gamete generation (GO:0007276)5.99317103
24positive regulation of gamma-delta T cell activation (GO:0046645)5.71536268
25regulation of inclusion body assembly (GO:0090083)5.63098458
26chromosome condensation (GO:0030261)5.52124893
27germ cell development (GO:0007281)5.33886407
28calcium ion-dependent exocytosis (GO:0017156)5.31897185
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.30884701
30DNA packaging (GO:0006323)5.18785653
31regulation of microtubule-based movement (GO:0060632)5.03934093
32ventricular system development (GO:0021591)5.03478952
33microtubule severing (GO:0051013)4.99793271
34glycerol ether metabolic process (GO:0006662)4.93990961
35cell recognition (GO:0008037)4.93868613
36spermatid nucleus differentiation (GO:0007289)4.86738884
37* multicellular organismal reproductive process (GO:0048609)4.71441338
38seminiferous tubule development (GO:0072520)4.67529034
39chromosome organization involved in meiosis (GO:0070192)4.65127880
40male meiosis I (GO:0007141)4.59224232
41ether metabolic process (GO:0018904)4.54513660
42regulation of B cell receptor signaling pathway (GO:0050855)4.41404151
43regulation of gamma-delta T cell activation (GO:0046643)4.38092750
44histone H3-K36 demethylation (GO:0070544)4.32150670
45sexual reproduction (GO:0019953)4.30351497
46regulation of gamma-delta T cell differentiation (GO:0045586)4.27199904
47sequestering of actin monomers (GO:0042989)4.25510391
48B cell receptor signaling pathway (GO:0050853)4.21967735
49chaperone-mediated protein complex assembly (GO:0051131)4.20607812
50DNA methylation involved in gamete generation (GO:0043046)4.18443347
51left/right pattern formation (GO:0060972)4.17557872
52negative regulation of cell killing (GO:0031342)4.16803820
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16803820
54negative thymic T cell selection (GO:0045060)4.11486795
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.09510160
56single strand break repair (GO:0000012)4.06112565
57meiotic nuclear division (GO:0007126)4.03829026
58negative regulation of erythrocyte differentiation (GO:0045647)4.00428537
59negative T cell selection (GO:0043383)3.99575337
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82160175
61positive thymic T cell selection (GO:0045059)3.81600330
62regulation of histone H3-K27 methylation (GO:0061085)3.81524319
63positive regulation by symbiont of host defense response (GO:0052509)3.81421720
64modulation by symbiont of host defense response (GO:0052031)3.81421720
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81421720
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81421720
67positive regulation by organism of defense response of other organism involved in symbiotic interact3.81421720
68modulation by symbiont of host immune response (GO:0052553)3.81421720
69* multicellular organismal development (GO:0007275)3.81374379
70response to muramyl dipeptide (GO:0032495)3.80500233
71meiosis I (GO:0007127)3.69027012
72genitalia morphogenesis (GO:0035112)3.68970703
73positive T cell selection (GO:0043368)3.68875745
74positive regulation of granulocyte differentiation (GO:0030854)3.68373591
75nuclear pore complex assembly (GO:0051292)3.59064554
76thymic T cell selection (GO:0045061)3.53942290
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52468108
78T cell selection (GO:0045058)3.47357705
79histone H3-K4 trimethylation (GO:0080182)3.46044894
80mitotic sister chromatid cohesion (GO:0007064)3.43077182
81protein polyglutamylation (GO:0018095)3.42820876
82interferon-gamma secretion (GO:0072643)3.42636754
83monoubiquitinated protein deubiquitination (GO:0035520)3.38390861
84antigen processing and presentation of endogenous antigen (GO:0019883)3.35056469
85protein K11-linked deubiquitination (GO:0035871)3.34265646
86protein localization to cilium (GO:0061512)3.33796974
87meiotic cell cycle (GO:0051321)3.31944360
88response to interleukin-15 (GO:0070672)3.31305150
89macrophage activation involved in immune response (GO:0002281)3.28030937
90positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27847023
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27340503
92regulation of spindle checkpoint (GO:0090231)3.27309176
93regulation of interferon-beta biosynthetic process (GO:0045357)3.25884116
94positive regulation of B cell differentiation (GO:0045579)3.22914777
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.17232263
96cellular extravasation (GO:0045123)3.14856533
97response to peptidoglycan (GO:0032494)3.14139574
98nucleoside diphosphate phosphorylation (GO:0006165)3.13859305
99regulation of B cell differentiation (GO:0045577)3.13554238
100B cell homeostasis (GO:0001782)3.13186166
101nucleus organization (GO:0006997)3.12773846
102histone lysine demethylation (GO:0070076)3.12572253
103microtubule polymerization or depolymerization (GO:0031109)3.09436292
104GTP biosynthetic process (GO:0006183)3.09057298
105RNA localization (GO:0006403)3.08676576
106natural killer cell differentiation (GO:0001779)3.08508876
107glycolytic process (GO:0006096)3.08377433
108germinal center formation (GO:0002467)3.07682029
109detection of other organism (GO:0098543)3.07172558
110modulation by virus of host process (GO:0019054)3.04890196
111protein refolding (GO:0042026)3.04790087
112cellular response to ethanol (GO:0071361)3.04008042
113histone demethylation (GO:0016577)3.03687315
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03343404
115negative regulation of lymphocyte mediated immunity (GO:0002707)2.98769899
116positive regulation of macrophage activation (GO:0043032)2.97574659
117polyol catabolic process (GO:0046174)2.94261920
118protein-DNA complex disassembly (GO:0032986)2.92921595
119nucleosome disassembly (GO:0006337)2.92921595
120regulation of granulocyte differentiation (GO:0030852)2.92376344
121amino-acid betaine transport (GO:0015838)2.91981444
122carnitine transport (GO:0015879)2.91981444
123mannose metabolic process (GO:0006013)2.91761434
124negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91691678
125chromatin silencing (GO:0006342)2.91100567
126detection of bacterium (GO:0016045)2.90174645
127leukocyte aggregation (GO:0070486)2.89197010
128response to host defenses (GO:0052200)2.87962294
129response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87962294
130response to host (GO:0075136)2.87962294
131histone H3-K4 methylation (GO:0051568)2.86975653
132detection of molecule of bacterial origin (GO:0032490)2.86974256
133phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.86730477
134response to laminar fluid shear stress (GO:0034616)2.85565348
135UTP biosynthetic process (GO:0006228)2.85227603
136RNA destabilization (GO:0050779)2.84539915
137negative regulation of T cell mediated immunity (GO:0002710)2.83958028
138response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82447260
139response to host immune response (GO:0052572)2.82447260
140positive regulation of interferon-alpha production (GO:0032727)2.81292890
141T cell migration (GO:0072678)2.81021861
142tolerance induction (GO:0002507)2.79994380
143cellular response to virus (GO:0098586)2.79613339
144protein localization to chromosome, centromeric region (GO:0071459)2.77802550
1453-UTR-mediated mRNA stabilization (GO:0070935)2.77092049
146modulation by symbiont of host cellular process (GO:0044068)2.76940594
147carnitine transmembrane transport (GO:1902603)2.76559411
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75264842
149meiotic cell cycle process (GO:1903046)2.74523729
150histone H3-K9 modification (GO:0061647)2.74399712
151histone H3-K9 demethylation (GO:0033169)2.72649328
152detection of external biotic stimulus (GO:0098581)2.72620046
153alditol metabolic process (GO:0019400)2.72580164
154regulation of T-helper 2 cell differentiation (GO:0045628)2.72461585
155dosage compensation (GO:0007549)2.71868956
156activated T cell proliferation (GO:0050798)2.70140080
157synapsis (GO:0007129)2.69720523
158cilium morphogenesis (GO:0060271)2.69340357
159pore complex assembly (GO:0046931)2.68095192
160gene silencing by RNA (GO:0031047)2.67308816
161axoneme assembly (GO:0035082)2.67272074
162cilium organization (GO:0044782)2.67105650
163regulation of cilium assembly (GO:1902017)2.66025259
164UTP metabolic process (GO:0046051)2.64654381
165lactate metabolic process (GO:0006089)2.64195450
166microtubule nucleation (GO:0007020)2.63280318
167regulation of necroptotic process (GO:0060544)2.62631558
168CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.61108544
169nuclear pore organization (GO:0006999)2.61029736
170gene silencing (GO:0016458)2.60192924
171protein targeting to Golgi (GO:0000042)2.60154773
172protein demethylation (GO:0006482)2.60045264
173protein dealkylation (GO:0008214)2.60045264
174negative regulation of histone methylation (GO:0031061)2.59988470
175microtubule-based movement (GO:0007018)2.59827849
176peptidyl-lysine trimethylation (GO:0018023)2.59660648
177negative regulation of leukocyte mediated immunity (GO:0002704)2.58545526
178retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58508179
179regulation of ARF GTPase activity (GO:0032312)2.57802834
180intraciliary transport (GO:0042073)2.57529524
181membrane protein intracellular domain proteolysis (GO:0031293)2.56742104
182establishment of protein localization to Golgi (GO:0072600)2.56712683
183antigen receptor-mediated signaling pathway (GO:0050851)2.55566189
184mucosal-associated lymphoid tissue development (GO:0048537)2.55480676
185Peyers patch development (GO:0048541)2.55480676
186NIK/NF-kappaB signaling (GO:0038061)2.55479964
187negative regulation of T-helper cell differentiation (GO:0045623)2.51668871
188negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51668871
189negative regulation of interleukin-12 production (GO:0032695)2.50538255
190sperm motility (GO:0030317)13.7594793
191fusion of sperm to egg plasma membrane (GO:0007342)13.0493037
192cell wall macromolecule catabolic process (GO:0016998)12.5791372
193cell wall macromolecule metabolic process (GO:0044036)12.5791372
194acrosome reaction (GO:0007340)12.1090049
195sperm-egg recognition (GO:0035036)11.6129643
196acrosome assembly (GO:0001675)11.4905816
197binding of sperm to zona pellucida (GO:0007339)10.7766290
198multicellular organism reproduction (GO:0032504)10.6608155
199cell-cell recognition (GO:0009988)10.4569800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.16358982
2EZH2_22144423_ChIP-Seq_EOC_Human4.11317190
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.10349350
4MYC_22102868_ChIP-Seq_BL_Human4.03401654
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98624292
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44954025
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.31615805
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15375128
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98279579
10VDR_21846776_ChIP-Seq_THP-1_Human2.97807128
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.92645531
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.88232735
13RUNX_20019798_ChIP-Seq_JUKART_Human2.83071460
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.82349222
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.77116193
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71059329
17TCF7_22412390_ChIP-Seq_EML_Mouse2.61748204
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60823122
19MAF_26560356_Chip-Seq_TH1_Human2.59228329
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.54443525
21MYB_26560356_Chip-Seq_TH2_Human2.54216372
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46692050
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.44169773
24MYB_26560356_Chip-Seq_TH1_Human2.42784765
25VDR_24763502_ChIP-Seq_THP-1_Human2.41711695
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.41388823
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39756121
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38490022
29UTX_26944678_Chip-Seq_JUKART_Human2.37978595
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36503822
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34941397
32SCL_19346495_ChIP-Seq_HPC-7_Human2.32637096
33KDM2B_26808549_Chip-Seq_DND41_Human2.25761567
34* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17707952
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15871933
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13637090
37SPI1_23127762_ChIP-Seq_K562_Human2.10428731
38GATA1_26923725_Chip-Seq_HPCs_Mouse2.06871532
39IRF8_27001747_Chip-Seq_BMDM_Mouse2.06799518
40* MAF_26560356_Chip-Seq_TH2_Human2.04016372
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03679053
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02104939
43IRF8_21731497_ChIP-ChIP_J774_Mouse2.01458812
44CIITA_25753668_ChIP-Seq_RAJI_Human2.00107728
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2328468
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89765271
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88293604
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.87565499
49VDR_22108803_ChIP-Seq_LS180_Human1.83445564
50ZNF274_21170338_ChIP-Seq_K562_Hela1.82369027
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81800158
52SPI1_23547873_ChIP-Seq_NB4_Human1.74909007
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68928661
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.68254434
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.67379154
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67265035
57GATA3_27048872_Chip-Seq_THYMUS_Human1.65703158
58STAT1_17558387_ChIP-Seq_HELA_Human1.64991336
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64867136
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.64521629
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.64246575
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.62504503
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.62425887
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61364549
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60577509
66GATA1_19941826_ChIP-Seq_K562_Human1.60058206
67GATA3_21867929_ChIP-Seq_CD8_Mouse1.58434162
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55205448
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55178008
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52521378
71GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51304030
72VDR_24787735_ChIP-Seq_THP-1_Human1.45791179
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.45638872
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41106461
75* P53_21459846_ChIP-Seq_SAOS-2_Human1.39790343
76SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38777906
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37525329
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36151879
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35094183
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34936762
81NCOR1_26117541_ChIP-Seq_K562_Human1.33472403
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33153429
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33078441
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32418466
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32415042
86CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32131344
87* PU_27001747_Chip-Seq_BMDM_Mouse1.31636820
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31311902
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30743228
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28807357
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.28465343
92KDM2B_26808549_Chip-Seq_REH_Human1.28324841
93PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22432789
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22406581
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.22296664
96KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22001728
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21102979
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21070452
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21060606
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20648545
101LXR_22292898_ChIP-Seq_THP-1_Human1.20502045
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19808810
103CBP_20019798_ChIP-Seq_JUKART_Human1.19808810
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.19553443
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18883205
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17974881
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17692034
108GATA2_19941826_ChIP-Seq_K562_Human1.17676215
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17465227
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16004365
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.15991279
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.15707058
113CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14852436
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.14476372
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13949361
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13858292
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13672442
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13133878
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11911757
120RARA_24833708_ChIP-Seq_LIVER_Mouse1.11421284
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.10433751
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09048755
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.08445344
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08403955
125FLI1_21867929_ChIP-Seq_CD8_Mouse1.08143658
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07260455
127GATA3_26560356_Chip-Seq_TH2_Human1.07147582
128GF1_26923725_Chip-Seq_HPCs_Mouse1.06755033
129BCOR_27268052_Chip-Seq_Bcells_Human1.05956641
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.05804362
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05390604
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05319863
133CTCF_20526341_ChIP-Seq_ESCs_Human1.04079974
134ERG_20517297_ChIP-Seq_VCAP_Human1.03646239
135MYC_27129775_Chip-Seq_CORNEA_Mouse1.03272549
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03217960
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03217960
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03202321
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03025956
140PHF8_20622854_ChIP-Seq_HELA_Human1.02673704
141JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02190077
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01992281
143RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01789552
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00747408
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00333665
146SOX11_22085726_ChIP-Seq_ESNs_Mouse0.99991103
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99911083
148SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99904787
149TFEB_21752829_ChIP-Seq_HELA_Human0.99676643
150KDM2B_26808549_Chip-Seq_K562_Human0.99079687
151* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98508457
152LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96576307
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.96215226
154CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96060488
155PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95922787
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95891957
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.95089371
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95028145
159SMC4_20622854_ChIP-Seq_HELA_Human0.94453378
160FOXA2_19822575_ChIP-Seq_HepG2_Human0.94393393
161PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93904403
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.93032691
163SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92373462
164BCL6_27268052_Chip-Seq_Bcells_Human0.91660502
165SOX2_21211035_ChIP-Seq_LN229_Human0.91436831
166MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90179035
167NANOG_20526341_ChIP-Seq_ESCs_Human0.89892897
168CBX2_27304074_Chip-Seq_ESCs_Mouse0.89578960
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89060270
170RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88435713
171VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88389320
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86753996
173REST_21632747_ChIP-Seq_MESCs_Mouse0.85768134
174* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83468667
175FOXM1_23109430_ChIP-Seq_U2OS_Human0.83416726
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83402696
177SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83320812
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83170166
179PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82285101
180RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82048099
181CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81990757
182CRX_20693478_ChIP-Seq_RETINA_Mouse0.81921852
183RACK7_27058665_Chip-Seq_MCF-7_Human0.80313071
184CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78690765
185GATA2_21666600_ChIP-Seq_HMVEC_Human0.78616629
186P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77162907
187KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76624030
188P68_20966046_ChIP-Seq_HELA_Human0.74510809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.81001551
2MP0001929_abnormal_gametogenesis5.35663662
3MP0008877_abnormal_DNA_methylation4.05682264
4MP0005451_abnormal_body_composition3.48668575
5MP0002210_abnormal_sex_determination3.24132513
6MP0002161_abnormal_fertility/fecundity3.17215426
7MP0003172_abnormal_lysosome_physiology3.17085568
8MP0002396_abnormal_hematopoietic_system3.06890894
9MP0001145_abnormal_male_reproductive2.75717939
10MP0003303_peritoneal_inflammation2.64794144
11MP0005670_abnormal_white_adipose2.60913503
12MP0000653_abnormal_sex_gland2.36188860
13MP0001790_abnormal_immune_system2.32031137
14MP0005387_immune_system_phenotype2.32031137
15MP0005076_abnormal_cell_differentiation2.24173480
16MP0004381_abnormal_hair_follicle2.19412518
17MP0005000_abnormal_immune_tolerance2.19115821
18MP0003656_abnormal_erythrocyte_physiolo2.15218724
19MP0002419_abnormal_innate_immunity2.08498092
20MP0005671_abnormal_response_to2.02291118
21MP0005410_abnormal_fertilization16.3546039
22MP0002653_abnormal_ependyma_morphology1.95237691
23MP0008260_abnormal_autophagy1.94881376
24MP0002009_preneoplasia1.87365739
25MP0003724_increased_susceptibility_to1.80075463
26MP0002160_abnormal_reproductive_system1.78919254
27MP0004947_skin_inflammation1.75820913
28MP0002166_altered_tumor_susceptibility1.71019637
29MP0003091_abnormal_cell_migration1.68760301
30MP0005464_abnormal_platelet_physiology1.59890121
31MP0001984_abnormal_olfaction1.55829081
32MP0005310_abnormal_salivary_gland1.50196997
33MP0001853_heart_inflammation1.46039912
34MP0000465_gastrointestinal_hemorrhage1.24881382
35MP0009333_abnormal_splenocyte_physiolog1.21848954
36MP0009785_altered_susceptibility_to1.19997974
37MP0005058_abnormal_lysosome_morphology1.13745096
38MP0004233_abnormal_muscle_weight1.13098188
39MP0005377_hearing/vestibular/ear_phenot1.09367806
40MP0003878_abnormal_ear_physiology1.09367806
41MP0002282_abnormal_trachea_morphology1.09333198
42MP0001845_abnormal_inflammatory_respons1.08926377
43MP0010155_abnormal_intestine_physiology1.08779853
44MP0005408_hypopigmentation1.08403658
45MP0002998_abnormal_bone_remodeling1.07052028
46MP0001533_abnormal_skeleton_physiology1.07046172
47MP0001765_abnormal_ion_homeostasis1.05489693
48MP0005623_abnormal_meninges_morphology1.05128481
49MP0005621_abnormal_cell_physiology1.03631557
50MP0003566_abnormal_cell_adhesion1.02455284
51MP0001915_intracranial_hemorrhage1.01805929
52MP0000858_altered_metastatic_potential1.01665675
53MP0003828_pulmonary_edema1.00508470
54MP0009278_abnormal_bone_marrow1.00494828
55MP0002138_abnormal_hepatobiliary_system0.98313437
56MP0003646_muscle_fatigue0.98304568
57MP0003866_abnormal_defecation0.98217996
58MP0008058_abnormal_DNA_repair0.94913591
59MP0004883_abnormal_blood_vessel0.92833036
60MP0002019_abnormal_tumor_incidence0.92271216
61MP0002006_tumorigenesis0.92263567
62MP0005389_reproductive_system_phenotype0.91559218
63MP0003705_abnormal_hypodermis_morpholog0.91203420
64MP0005075_abnormal_melanosome_morpholog0.91031553
65MP0000371_diluted_coat_color0.89770981
66MP0003045_fibrosis0.87687842
67MP0003787_abnormal_imprinting0.87016770
68MP0001661_extended_life_span0.84592769
69MP0003115_abnormal_respiratory_system0.84154958
70MP0001545_abnormal_hematopoietic_system0.81866929
71MP0005397_hematopoietic_system_phenotyp0.81866929
72MP0010094_abnormal_chromosome_stability0.81194492
73MP0002933_joint_inflammation0.81175872
74MP0003183_abnormal_peptide_metabolism0.78887702
75MP0008469_abnormal_protein_level0.77939160
76MP0002970_abnormal_white_adipose0.76624183
77MP0006082_CNS_inflammation0.73483730
78MP0005647_abnormal_sex_gland0.72876436
79MP0002928_abnormal_bile_duct0.72424757
80MP0005409_darkened_coat_color0.71886264
81MP0004130_abnormal_muscle_cell0.71634864
82MP0004264_abnormal_extraembryonic_tissu0.71508415
83MP0002148_abnormal_hypersensitivity_rea0.68540440
84MP0004510_myositis0.67924810
85MP0002234_abnormal_pharynx_morphology0.67156457
86MP0000249_abnormal_blood_vessel0.65868640
87MP0000609_abnormal_liver_physiology0.65764238
88MP0003453_abnormal_keratinocyte_physiol0.65601899
89MP0002405_respiratory_system_inflammati0.65401196
90MP0004808_abnormal_hematopoietic_stem0.63210122
91MP0003221_abnormal_cardiomyocyte_apopto0.62949363
92MP0001986_abnormal_taste_sensitivity0.62359859
93MP0003191_abnormal_cellular_cholesterol0.61721555
94MP0005384_cellular_phenotype0.61558574
95MP0002877_abnormal_melanocyte_morpholog0.61345905
96MP0000685_abnormal_immune_system0.58651763
97MP0008995_early_reproductive_senescence0.55445177
98MP0000358_abnormal_cell_content/0.54716735
99MP0005636_abnormal_mineral_homeostasis0.53329293
100MP0001293_anophthalmia0.52869879
101MP0001348_abnormal_lacrimal_gland0.52109776
102MP0003111_abnormal_nucleus_morphology0.52062023
103MP0003763_abnormal_thymus_physiology0.51471816
104MP0001849_ear_inflammation0.51400586
105MP0010307_abnormal_tumor_latency0.51134696
106MP0001730_embryonic_growth_arrest0.49962331
107MP0000569_abnormal_digit_pigmentation0.48731908
108MP0003011_delayed_dark_adaptation0.48457103
109MP0009115_abnormal_fat_cell0.48298527
110MP0005174_abnormal_tail_pigmentation0.48011642
111MP0008007_abnormal_cellular_replicative0.48010616
112MP0001324_abnormal_eye_pigmentation0.43319874
113MP0002398_abnormal_bone_marrow0.42620368
114MP0002132_abnormal_respiratory_system0.42420115
115MP0005666_abnormal_adipose_tissue0.42252407
116MP0000703_abnormal_thymus_morphology0.41015565
117MP0008057_abnormal_DNA_replication0.40978267
118MP0003699_abnormal_female_reproductive0.39441004
119MP0003077_abnormal_cell_cycle0.38379810
120MP0003300_gastrointestinal_ulcer0.37716266
121MP0002092_abnormal_eye_morphology0.36235606
122MP0000313_abnormal_cell_death0.35856111
123MP0002269_muscular_atrophy0.35360031
124MP0002723_abnormal_immune_serum0.33000432
125MP0001873_stomach_inflammation0.32716328
126MP0006036_abnormal_mitochondrial_physio0.32652196
127MP0000534_abnormal_ureter_morphology0.32117802
128MP0001800_abnormal_humoral_immune0.32032225
129MP0001764_abnormal_homeostasis0.31722166
130MP0003942_abnormal_urinary_system0.31559712
131MP0005391_vision/eye_phenotype0.28518410
132MP0008961_abnormal_basal_metabolism0.28474392
133MP0001119_abnormal_female_reproductive0.28464992
134MP0000716_abnormal_immune_system0.28160181
135MP0002452_abnormal_antigen_presenting0.27928252
136MP0002420_abnormal_adaptive_immunity0.27307183
137MP0000689_abnormal_spleen_morphology0.26980968
138MP0001672_abnormal_embryogenesis/_devel0.26400883
139MP0005380_embryogenesis_phenotype0.26400883
140MP0001819_abnormal_immune_cell0.26168629
141MP0002084_abnormal_developmental_patter0.26097408
142MP0001835_abnormal_antigen_presentation0.25808027
143MP0002169_no_abnormal_phenotype0.25569139
144MP0002080_prenatal_lethality0.25567395
145MP0002873_normal_phenotype0.25088399
146MP0003329_amyloid_beta_deposits0.24414193
147MP0002429_abnormal_blood_cell0.24090220
148MP0003436_decreased_susceptibility_to0.23839562
149MP0003984_embryonic_growth_retardation0.23835049
150MP0001697_abnormal_embryo_size0.23678594
151MP0005375_adipose_tissue_phenotype0.23658534
152MP0002722_abnormal_immune_system0.23046184
153MP0002088_abnormal_embryonic_growth/wei0.22224594
154MP0008770_decreased_survivor_rate0.21474783
155MP0000015_abnormal_ear_pigmentation0.20350220
156MP0003786_premature_aging0.20256256
157MP0003861_abnormal_nervous_system0.19843188
158MP0001851_eye_inflammation0.19563853
159MP0004133_heterotaxia0.19413870
160MP0003279_aneurysm0.19204619
161MP0005025_abnormal_response_to0.18792365
162MP0004036_abnormal_muscle_relaxation0.18444807
163MP0000604_amyloidosis0.18031379

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.32897791
2Abnormal respiratory motile cilium morphology (HP:0005938)9.27510574
3Abnormal respiratory epithelium morphology (HP:0012253)9.27510574
4Rhinitis (HP:0012384)7.52743714
5Chronic bronchitis (HP:0004469)7.44213971
6Abnormal ciliary motility (HP:0012262)7.25226868
7Nasal polyposis (HP:0100582)6.97401849
8Infertility (HP:0000789)6.86679917
9Abnormality of the nasal mucosa (HP:0000433)5.71867909
10Bronchitis (HP:0012387)4.99057762
11Bronchiectasis (HP:0002110)4.68640664
12Male infertility (HP:0003251)4.59834579
13Abnormality of the fingertips (HP:0001211)4.37218518
14Nephronophthisis (HP:0000090)4.09965802
15Recurrent sinusitis (HP:0011108)3.82437648
16Recurrent otitis media (HP:0000403)3.73370752
17Eczematoid dermatitis (HP:0000976)3.70437995
18Colitis (HP:0002583)3.41142882
19Recurrent bacterial skin infections (HP:0005406)3.39624940
20Recurrent bronchitis (HP:0002837)3.35620290
21Abnormal spermatogenesis (HP:0008669)3.33923113
22Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.30728111
23Recurrent fungal infections (HP:0002841)3.20535970
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.17020255
25Recurrent abscess formation (HP:0002722)3.12269601
26Panhypogammaglobulinemia (HP:0003139)3.09464970
27Recurrent viral infections (HP:0004429)3.06536297
28Abnormality of the renal medulla (HP:0100957)3.03573466
29Prolonged bleeding time (HP:0003010)2.93517337
30Gastrointestinal infarctions (HP:0005244)2.93057739
31Gastrointestinal stroma tumor (HP:0100723)2.92069864
32T lymphocytopenia (HP:0005403)2.91180076
33Agammaglobulinemia (HP:0004432)2.90054620
34Vasculitis (HP:0002633)2.82842400
35Meningitis (HP:0001287)2.81552135
36Inflammation of the large intestine (HP:0002037)2.76894267
37Molar tooth sign on MRI (HP:0002419)2.76184982
38Abnormality of midbrain morphology (HP:0002418)2.76184982
39Cellulitis (HP:0100658)2.75326000
40Gastrointestinal inflammation (HP:0004386)2.72681904
41Recurrent cutaneous fungal infections (HP:0011370)2.72321933
42Chronic mucocutaneous candidiasis (HP:0002728)2.72321933
43Impulsivity (HP:0100710)2.69000907
44Lymphopenia (HP:0001888)2.68416419
45Pustule (HP:0200039)2.67995054
46Viral hepatitis (HP:0006562)2.64261480
47Abnormality of T cell number (HP:0011839)2.58229413
48Broad face (HP:0000283)2.57964778
49Dislocated radial head (HP:0003083)2.54238214
50Myositis (HP:0100614)2.53498979
51Tubular atrophy (HP:0000092)2.52993206
52Prominent nose (HP:0000448)2.48397180
53Recurrent skin infections (HP:0001581)2.48143564
54Abnormality of the columella (HP:0009929)2.46935602
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.45282933
56Tubulointerstitial nephritis (HP:0001970)2.43826438
57Hypoplasia of the thymus (HP:0000778)2.42279355
58Optic neuritis (HP:0100653)2.41414700
59Retrobulbar optic neuritis (HP:0100654)2.41414700
60Mediastinal lymphadenopathy (HP:0100721)2.41380009
61Orchitis (HP:0100796)2.38708862
62Spondylolisthesis (HP:0003302)2.38653168
63Epistaxis (HP:0000421)2.37418800
64Abnormality of T cells (HP:0002843)2.36148544
65Abnormality of macrophages (HP:0004311)2.35267064
66Gonadotropin excess (HP:0000837)2.31932125
67Abnormal gallbladder physiology (HP:0012438)2.31695862
68Cholecystitis (HP:0001082)2.31695862
69Stomatitis (HP:0010280)2.31509140
70Abnormality of the radial head (HP:0003995)2.29142953
71Gingivitis (HP:0000230)2.28080472
72Increased IgE level (HP:0003212)2.27076121
73Sparse lateral eyebrow (HP:0005338)2.26031623
74Spontaneous hematomas (HP:0007420)2.25214237
75Slow saccadic eye movements (HP:0000514)2.23813022
76Recurrent gram-negative bacterial infections (HP:0005420)2.23656809
77Abnormality of the peritoneum (HP:0002585)2.22931451
78Papilloma (HP:0012740)2.22283459
79Verrucae (HP:0200043)2.22283459
80Long eyelashes (HP:0000527)2.19311550
81Tubulointerstitial abnormality (HP:0001969)2.18881569
82Medial flaring of the eyebrow (HP:0010747)2.17193491
83Elevated erythrocyte sedimentation rate (HP:0003565)2.17177899
84Emphysema (HP:0002097)2.15832513
85Acute hepatic failure (HP:0006554)2.13986602
86Subacute progressive viral hepatitis (HP:0006572)2.12996648
87Granulocytopenia (HP:0001913)2.10898067
88Gingival bleeding (HP:0000225)2.08367028
89Encephalitis (HP:0002383)2.07713453
90Basal cell carcinoma (HP:0002671)2.05992690
91Fatigue (HP:0012378)2.01588048
92Heterotopia (HP:0002282)2.00906741
93Absent/shortened dynein arms (HP:0200106)13.3431749
94Dynein arm defect of respiratory motile cilia (HP:0012255)13.3431749
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9533337
96Chest pain (HP:0100749)1.99516038
97IgM deficiency (HP:0002850)1.98372116
98Dyschromatopsia (HP:0007641)1.97902909
99Abnormality of T cell physiology (HP:0011840)1.97783973
100Broad palm (HP:0001169)1.96377673
101Abnormal platelet volume (HP:0011876)1.94433134
102Deep venous thrombosis (HP:0002625)1.93079794
103Peritonitis (HP:0002586)1.93010114
104Hemorrhage of the eye (HP:0011885)1.91878056
105Autoimmune hemolytic anemia (HP:0001890)1.90174471
106Menorrhagia (HP:0000132)1.89941509
107Keratoconjunctivitis sicca (HP:0001097)1.89189063
108Hepatitis (HP:0012115)1.88350726
109Osteomyelitis (HP:0002754)1.88016706
110Arterial thrombosis (HP:0004420)1.84828429
111Hypochromic anemia (HP:0001931)1.84261361
112Tubulointerstitial fibrosis (HP:0005576)1.84255222
113Azoospermia (HP:0000027)1.83973412
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83107697
115Leukocytosis (HP:0001974)1.82599687
116Narrow palate (HP:0000189)1.81453028
117Chronic obstructive pulmonary disease (HP:0006510)1.79984944
118Obstructive lung disease (HP:0006536)1.79984944
119Homocystinuria (HP:0002156)1.79374538
120Abnormality of homocysteine metabolism (HP:0010919)1.79374538
121Stage 5 chronic kidney disease (HP:0003774)1.79132462
122Obstructive sleep apnea (HP:0002870)1.78957257
123Choroideremia (HP:0001139)1.78379621
124Restrictive lung disease (HP:0002091)1.77433974
125Onion bulb formation (HP:0003383)1.76751952
126Sandal gap (HP:0001852)1.75372174
127Postaxial foot polydactyly (HP:0001830)1.73001671
128Chronic sinusitis (HP:0011109)1.72428705
129Lymphoma (HP:0002665)1.71031824
130Supernumerary nipples (HP:0002558)1.69828584
131Autoimmune thrombocytopenia (HP:0001973)1.69790855
132Aplasia/Hypoplasia of the thymus (HP:0010515)1.67558048
133Spastic tetraparesis (HP:0001285)1.67539371
134Thin bony cortex (HP:0002753)1.67347163
135Abnormality of the common coagulation pathway (HP:0010990)1.66789351
136Polydipsia (HP:0001959)1.65830840
137Abnormal drinking behavior (HP:0030082)1.65830840
138Decreased central vision (HP:0007663)1.64184142
139Keratoconjunctivitis (HP:0001096)1.63659501
140Abnormality of renal excretion (HP:0011036)1.59551316
141Oculomotor apraxia (HP:0000657)1.57381577
142Bile duct proliferation (HP:0001408)1.57087499
143Abnormal biliary tract physiology (HP:0012439)1.57087499
144Asymmetric septal hypertrophy (HP:0001670)1.56625646
145Abnormality of the dental root (HP:0006486)1.54938537
146Taurodontia (HP:0000679)1.54938537
147Abnormality of permanent molar morphology (HP:0011071)1.54938537
148Short ribs (HP:0000773)1.52439700
149Congenital hepatic fibrosis (HP:0002612)1.51224283
150Abnormality of the renal cortex (HP:0011035)1.50699441
151Deformed sella turcica (HP:0002681)1.42799041
152Abnormality of the dental pulp (HP:0006479)1.42375861
153Abnormality of dentin (HP:0010299)1.41992937
154Bell-shaped thorax (HP:0001591)1.41670374
155Double outlet right ventricle (HP:0001719)1.40759638
156Congenital malformation of the right heart (HP:0011723)1.40759638
157Absent epiphyses (HP:0010577)1.40203217
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40203217
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.39480732
160Easy fatigability (HP:0003388)1.39300744
161Abnormality of molar morphology (HP:0011070)1.39282554
162Abnormality of molar (HP:0011077)1.39282554
163Postaxial hand polydactyly (HP:0001162)1.38272493
164Cystic liver disease (HP:0006706)1.36278666
165Constricted visual fields (HP:0001133)1.33350148
166Fibular hypoplasia (HP:0003038)1.33249296
167Renal dysplasia (HP:0000110)1.31321731
168Hypercholesterolemia (HP:0003124)1.30515999
169Abnormality of the lower motor neuron (HP:0002366)1.29199613
170Loss of speech (HP:0002371)1.29096103
171Aplasia/Hypoplasia of the lens (HP:0008063)1.28283790
172Absent frontal sinuses (HP:0002688)1.27674373
173Facial cleft (HP:0002006)1.27341107
174Abnormal urine output (HP:0012590)1.25369421
175Cerebellar dysplasia (HP:0007033)1.23437916
176Broad distal phalanx of finger (HP:0009836)1.22209458
177Truncal obesity (HP:0001956)1.19929388
178Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.17208178
179Fatigable weakness (HP:0003473)1.15657394
180Abnormality of the neuromuscular junction (HP:0003398)1.15657394
181Exercise-induced myalgia (HP:0003738)1.14722243
182Myoglobinuria (HP:0002913)1.12663624
183Short thorax (HP:0010306)1.12440588
184Impaired proprioception (HP:0010831)1.10911798
185Neurofibrillary tangles (HP:0002185)1.08815864
186Bundle branch block (HP:0011710)1.08733201
187Nephropathy (HP:0000112)1.08438368
188Sensory axonal neuropathy (HP:0003390)1.08227966
189Short femoral neck (HP:0100864)1.07429182
190Amyotrophic lateral sclerosis (HP:0007354)1.07275276
191Rhabdomyolysis (HP:0003201)1.03868713
192Short 4th metacarpal (HP:0010044)1.03719536
193Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.03719536
194Congenital primary aphakia (HP:0007707)1.03501822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.93639630
2PDK47.93639630
3TESK16.58328596
4PRKD34.98331411
5PDK24.97228504
6ICK4.60103026
7PRPF4B3.62231909
8BLK2.42755104
9BRD42.27628389
10PTK2B2.06415477
11SIK21.96041870
12NEK21.92648278
13WNK41.91083210
14TYK21.89838723
15MAP2K31.89634133
16MAP3K141.85186058
17FGFR41.82891647
18DYRK1B1.79962382
19STK391.74014181
20STK381.66827660
21MAP3K131.60258996
22EEF2K1.54778144
23FGFR31.49108651
24IRAK41.41312751
25PNCK1.39461583
26JAK31.37444898
27SYK1.35339308
28FGR1.34431035
29FES1.29635731
30JAK11.26302846
31MAP3K101.24304036
32SIK11.21264149
33PDK11.20935287
34SIK31.18446476
35TNK21.17004153
36TAOK31.16580066
37BMPR21.12993364
38CAMK1D1.12837476
39CDC42BPA1.12729431
40DYRK31.12670747
41PIK3CG1.12472700
42NEK61.10340696
43MAP3K71.06876145
44SMG11.06107835
45IKBKE1.05317763
46MAPK110.90562137
47PASK0.89137069
48PRKD20.88800815
49MAP4K10.88517764
50IRAK30.86273693
51TXK0.86237548
52IRAK10.86107108
53MAPK70.83436543
54TESK20.82701299
55LYN0.80649101
56JAK20.80389935
57SGK30.77394267
58WNK10.77087156
59TRIB30.76899157
60TYRO30.76782427
61RIPK40.74413039
62NLK0.74100102
63RET0.73694690
64MELK0.73191185
65STK30.71151458
66KSR20.70990631
67TEC0.68588735
68MAP2K60.67081555
69IKBKB0.66888121
70MAPK120.66851093
71MAP3K10.66259059
72SGK20.66230910
73YES10.65240581
74PDPK10.65234175
75CHUK0.64986408
76HIPK20.63117369
77AKT30.62158869
78MAPK150.61572572
79TTK0.59338731
80IRAK20.58839007
81STK100.58305200
82CCNB10.56709603
83PDGFRB0.56038604
84NEK90.53078756
85MAP3K20.49543237
86CHEK20.48529495
87BMX0.47698764
88MAP2K20.45965783
89CAMK40.45366581
90CAMK1G0.45260612
91TAOK20.44901930
92PAK20.44675840
93MAP3K30.41751092
94CLK10.41268955
95PAK10.40139289
96MAPK10.40126000
97CHEK10.39919482
98PRKAA20.38405894
99PRKCH0.36890192
100PAK40.36670496
101MTOR0.36101341
102ZAP700.32303352
103ATR0.31072171
104CDK120.31052368
105LMTK20.28232042
106STK38L0.26980976
107CDK60.25793772
108PIM10.25562859
109GRK60.24713764
110ATM0.24539558
111MARK30.23002096
112PLK40.22534062
113PRKCQ0.22469194
114CDK40.21863698
115MARK20.20924138
116CSF1R0.20301394
117NTRK20.17607719
118PKN20.17360278
119CAMKK10.16460682
120ERN10.16426611
121PRKCG0.15670319
122RIPK10.15604450
123TGFBR20.15240262
124CDC70.14489279
125CSK0.14069889
126PIM20.13503018
127PRKAA10.13129186
128TTN0.12805271
129RPS6KA10.10599736
130PLK10.10591531
131RPS6KB10.09783175
132PTK60.09416292
133TBK10.08743070
134MUSK0.08712123
135BTK0.08186597
136PRKG20.08077363
137SRPK10.07939225
138CDK150.06710782
139MAP3K50.06234884
140PRKCZ0.05372534
141LRRK20.04994984
142CDK20.04794569
143HCK0.04144478
144LCK0.04122441
145MST1R0.04084636
146CDK11A0.04060688
147WEE10.03509704
148CDK180.03002791
149CSNK2A10.02485205
150MAPKAPK50.02340603
151ITK0.02221900
152EGFR0.02114200
153STK40.01786249
154CSNK1D0.01564597
155GSK3B0.00471478
156AURKB-0.0081063
157CSNK2A2-0.0077736
158MAP3K8-0.0032630
159EPHB1-0.0029938
160STK11-0.0008905

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.54200687
2Fatty acid biosynthesis_Homo sapiens_hsa000614.37470513
3Pyruvate metabolism_Homo sapiens_hsa006203.44197158
4Vitamin B6 metabolism_Homo sapiens_hsa007502.98688352
5Glucagon signaling pathway_Homo sapiens_hsa049222.73370462
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68213921
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.58744914
8Linoleic acid metabolism_Homo sapiens_hsa005912.58384026
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41652945
10Propanoate metabolism_Homo sapiens_hsa006402.35703146
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34049556
12Acute myeloid leukemia_Homo sapiens_hsa052212.21461049
13Basal transcription factors_Homo sapiens_hsa030222.12887653
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11268103
15Non-small cell lung cancer_Homo sapiens_hsa052232.01092368
16Selenocompound metabolism_Homo sapiens_hsa004502.00674499
17Glycerolipid metabolism_Homo sapiens_hsa005611.94680658
18Leishmaniasis_Homo sapiens_hsa051401.85962753
19Pentose phosphate pathway_Homo sapiens_hsa000301.81260512
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.80835603
21Other glycan degradation_Homo sapiens_hsa005111.80195962
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.76896559
23Chronic myeloid leukemia_Homo sapiens_hsa052201.73865899
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71090143
25Oocyte meiosis_Homo sapiens_hsa041141.70693090
26PPAR signaling pathway_Homo sapiens_hsa033201.65466231
27Hepatitis B_Homo sapiens_hsa051611.64824361
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.63114799
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60173575
30Pancreatic cancer_Homo sapiens_hsa052121.60011800
31Antigen processing and presentation_Homo sapiens_hsa046121.58589023
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.55789441
33mRNA surveillance pathway_Homo sapiens_hsa030151.53521334
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.42168660
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42167282
36Fructose and mannose metabolism_Homo sapiens_hsa000511.40893296
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40672929
38Dorso-ventral axis formation_Homo sapiens_hsa043201.39747692
39Herpes simplex infection_Homo sapiens_hsa051681.39693764
40Lysine degradation_Homo sapiens_hsa003101.39657795
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39272815
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38296866
43Staphylococcus aureus infection_Homo sapiens_hsa051501.34577866
44Endometrial cancer_Homo sapiens_hsa052131.34108314
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32997669
46Choline metabolism in cancer_Homo sapiens_hsa052311.32947851
47TNF signaling pathway_Homo sapiens_hsa046681.31691361
48Fanconi anemia pathway_Homo sapiens_hsa034601.31127149
49mTOR signaling pathway_Homo sapiens_hsa041501.26225084
50Tuberculosis_Homo sapiens_hsa051521.26008393
51Fat digestion and absorption_Homo sapiens_hsa049751.25145118
52Carbon metabolism_Homo sapiens_hsa012001.24850739
53Colorectal cancer_Homo sapiens_hsa052101.23320309
54Renal cell carcinoma_Homo sapiens_hsa052111.22198562
55FoxO signaling pathway_Homo sapiens_hsa040681.21818913
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.21438125
57Mineral absorption_Homo sapiens_hsa049781.20955405
58Amphetamine addiction_Homo sapiens_hsa050311.18244850
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.17913286
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17122727
61RNA transport_Homo sapiens_hsa030131.14835529
62Graft-versus-host disease_Homo sapiens_hsa053321.14700207
63Fatty acid degradation_Homo sapiens_hsa000711.14629335
64Notch signaling pathway_Homo sapiens_hsa043301.14503056
65Apoptosis_Homo sapiens_hsa042101.11283335
66Prostate cancer_Homo sapiens_hsa052151.10313838
67Prolactin signaling pathway_Homo sapiens_hsa049171.10275332
68Hepatitis C_Homo sapiens_hsa051601.09820415
69Allograft rejection_Homo sapiens_hsa053301.08975426
70B cell receptor signaling pathway_Homo sapiens_hsa046621.08848499
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08623163
72Cardiac muscle contraction_Homo sapiens_hsa042601.06110659
73Hematopoietic cell lineage_Homo sapiens_hsa046401.05953166
74Autoimmune thyroid disease_Homo sapiens_hsa053201.05434615
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.05061411
76Platelet activation_Homo sapiens_hsa046111.04574495
77Viral myocarditis_Homo sapiens_hsa054161.03494336
78Chemokine signaling pathway_Homo sapiens_hsa040621.00961831
79Purine metabolism_Homo sapiens_hsa002301.00359244
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99882114
81ErbB signaling pathway_Homo sapiens_hsa040120.98282521
82Fatty acid metabolism_Homo sapiens_hsa012120.98032352
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.98020466
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.94276148
85Systemic lupus erythematosus_Homo sapiens_hsa053220.92789460
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92019921
87Ether lipid metabolism_Homo sapiens_hsa005650.91729959
88Olfactory transduction_Homo sapiens_hsa047400.91304559
89Legionellosis_Homo sapiens_hsa051340.91253765
90Small cell lung cancer_Homo sapiens_hsa052220.87391748
91Glutathione metabolism_Homo sapiens_hsa004800.87350228
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.86652559
93Huntingtons disease_Homo sapiens_hsa050160.86194004
94MicroRNAs in cancer_Homo sapiens_hsa052060.85825271
95Renin secretion_Homo sapiens_hsa049240.85643317
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.84570990
97Glioma_Homo sapiens_hsa052140.82453090
98Thyroid cancer_Homo sapiens_hsa052160.81364050
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.81076933
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80769809
101VEGF signaling pathway_Homo sapiens_hsa043700.80430773
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80147133
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79853810
104GnRH signaling pathway_Homo sapiens_hsa049120.78405403
105Malaria_Homo sapiens_hsa051440.78290750
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76932170
107Estrogen signaling pathway_Homo sapiens_hsa049150.76844846
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76438184
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75680185
110T cell receptor signaling pathway_Homo sapiens_hsa046600.73899412
111Hedgehog signaling pathway_Homo sapiens_hsa043400.73894979
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.73355019
113Type II diabetes mellitus_Homo sapiens_hsa049300.73059456
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68923090
115Thyroid hormone synthesis_Homo sapiens_hsa049180.68391457
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67975620
117Collecting duct acid secretion_Homo sapiens_hsa049660.67760153
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67649138
119MAPK signaling pathway_Homo sapiens_hsa040100.64426089
120Insulin signaling pathway_Homo sapiens_hsa049100.62561836
121Chemical carcinogenesis_Homo sapiens_hsa052040.62348985
122Biosynthesis of amino acids_Homo sapiens_hsa012300.62228786
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61241021
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59281223
125AMPK signaling pathway_Homo sapiens_hsa041520.57519286
126Type I diabetes mellitus_Homo sapiens_hsa049400.57132129
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56920887
128Bile secretion_Homo sapiens_hsa049760.55298579
129African trypanosomiasis_Homo sapiens_hsa051430.54461327
130Renin-angiotensin system_Homo sapiens_hsa046140.52913249
131Long-term potentiation_Homo sapiens_hsa047200.52423580
132Viral carcinogenesis_Homo sapiens_hsa052030.51740215
133Endocytosis_Homo sapiens_hsa041440.50981474
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50394565
135Proteoglycans in cancer_Homo sapiens_hsa052050.50286351
136Insulin secretion_Homo sapiens_hsa049110.50141238
137Pyrimidine metabolism_Homo sapiens_hsa002400.49273585
138Measles_Homo sapiens_hsa051620.46656716
139Primary immunodeficiency_Homo sapiens_hsa053400.46480865
140Alcoholism_Homo sapiens_hsa050340.45497463
141Adherens junction_Homo sapiens_hsa045200.45321018
142DNA replication_Homo sapiens_hsa030300.44654987
143Bladder cancer_Homo sapiens_hsa052190.44463859
144Arachidonic acid metabolism_Homo sapiens_hsa005900.43367033
145ABC transporters_Homo sapiens_hsa020100.43251153
146Base excision repair_Homo sapiens_hsa034100.43006111
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42634980
148Inositol phosphate metabolism_Homo sapiens_hsa005620.42435819
149Toxoplasmosis_Homo sapiens_hsa051450.41439696
150Epstein-Barr virus infection_Homo sapiens_hsa051690.37481107
151Pancreatic secretion_Homo sapiens_hsa049720.36800063
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35343848
153Influenza A_Homo sapiens_hsa051640.33039970
154Gastric acid secretion_Homo sapiens_hsa049710.32379129
155Shigellosis_Homo sapiens_hsa051310.32177650
156Osteoclast differentiation_Homo sapiens_hsa043800.32063142
157Protein digestion and absorption_Homo sapiens_hsa049740.31151999
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29460380
159Salmonella infection_Homo sapiens_hsa051320.27770379
160HTLV-I infection_Homo sapiens_hsa051660.25677940
161HIF-1 signaling pathway_Homo sapiens_hsa040660.24669107
162Non-homologous end-joining_Homo sapiens_hsa034500.23715610
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23415384
164RNA degradation_Homo sapiens_hsa030180.23409899
165Insulin resistance_Homo sapiens_hsa049310.22683708

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