TSSK5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)4.82766825
2nuclear pore complex assembly (GO:0051292)4.81951967
3COPI coating of Golgi vesicle (GO:0048205)4.72872233
4Golgi transport vesicle coating (GO:0048200)4.72872233
5DNA unwinding involved in DNA replication (GO:0006268)4.39460694
6mitotic chromosome condensation (GO:0007076)4.28801304
7proline biosynthetic process (GO:0006561)4.26548873
8nuclear pore organization (GO:0006999)3.96300161
9activation of Rac GTPase activity (GO:0032863)3.93360742
10chromosome condensation (GO:0030261)3.86802313
11focal adhesion assembly (GO:0048041)3.78220224
12cell-substrate adherens junction assembly (GO:0007045)3.78220224
13negative regulation of cell size (GO:0045792)3.76000687
14regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73816305
15pore complex assembly (GO:0046931)3.65659821
16adherens junction assembly (GO:0034333)3.63947077
17spliceosomal tri-snRNP complex assembly (GO:0000244)3.54921873
18regulation of histone H3-K27 methylation (GO:0061085)3.54014359
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52200124
20protein retention in ER lumen (GO:0006621)3.47182613
21apoptotic process involved in morphogenesis (GO:0060561)3.46719657
22cell-substrate junction assembly (GO:0007044)3.42548640
23cellular protein complex localization (GO:0034629)3.30789364
24DNA packaging (GO:0006323)3.29070006
25retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27302701
26protein localization to endosome (GO:0036010)3.25775724
27protein complex localization (GO:0031503)3.20277008
28maternal placenta development (GO:0001893)3.18727020
29DNA duplex unwinding (GO:0032508)3.16191365
30hemidesmosome assembly (GO:0031581)3.11666503
31folic acid metabolic process (GO:0046655)3.10966732
32desmosome organization (GO:0002934)3.09716744
33peptidyl-arginine omega-N-methylation (GO:0035247)3.09634989
34establishment of apical/basal cell polarity (GO:0035089)3.07361456
35regulation of translational termination (GO:0006449)3.05737241
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04981034
37regulation of glucose import in response to insulin stimulus (GO:2001273)3.02955999
38regulation of early endosome to late endosome transport (GO:2000641)3.01398322
39regulation of RNA export from nucleus (GO:0046831)3.00963379
40DNA conformation change (GO:0071103)3.00711792
41ribosomal small subunit biogenesis (GO:0042274)2.97199764
42mitotic sister chromatid segregation (GO:0000070)2.92511359
43DNA geometric change (GO:0032392)2.91719937
44epithelial cell-cell adhesion (GO:0090136)2.90574402
45positive regulation of DNA-dependent DNA replication (GO:2000105)2.88941482
46protein localization to microtubule (GO:0035372)2.88746614
47peptidyl-lysine dimethylation (GO:0018027)2.88314142
48regulation of NFAT protein import into nucleus (GO:0051532)2.87088117
49pentose-phosphate shunt (GO:0006098)2.86864283
50positive regulation of keratinocyte differentiation (GO:0045618)2.86816041
51regulation of chromatin binding (GO:0035561)2.86510752
52DNA replication initiation (GO:0006270)2.86048466
53mannose metabolic process (GO:0006013)2.83963086
54mitotic nuclear envelope disassembly (GO:0007077)2.80384183
55regulation of nucleobase-containing compound transport (GO:0032239)2.79768178
56cytoskeletal anchoring at plasma membrane (GO:0007016)2.77018948
57protein export from nucleus (GO:0006611)2.76801474
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75045172
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74613677
60positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.73889278
61protein-DNA complex disassembly (GO:0032986)2.73517843
62nucleosome disassembly (GO:0006337)2.73517843
63basement membrane organization (GO:0071711)2.73313005
64membrane disassembly (GO:0030397)2.71145351
65nuclear envelope disassembly (GO:0051081)2.71145351
66sister chromatid segregation (GO:0000819)2.70299325
67positive regulation of nuclease activity (GO:0032075)2.69111059
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67712372
69snRNA metabolic process (GO:0016073)2.67646104
70RNA stabilization (GO:0043489)2.67376187
71mRNA stabilization (GO:0048255)2.67376187
72nuclear envelope organization (GO:0006998)2.67159908
73glucocorticoid receptor signaling pathway (GO:0042921)2.65965714
74formation of translation preinitiation complex (GO:0001731)2.65729268
75glucose catabolic process (GO:0006007)2.64595290
76UV protection (GO:0009650)2.62548001
77cellular response to epidermal growth factor stimulus (GO:0071364)2.62389261
78negative regulation of fatty acid transport (GO:2000192)2.62237918
79atrioventricular valve morphogenesis (GO:0003181)2.61187222
80proline metabolic process (GO:0006560)2.60699963
81nucleobase-containing small molecule interconversion (GO:0015949)2.58186725
82mitochondrial DNA metabolic process (GO:0032042)2.57229554
83endoplasmic reticulum unfolded protein response (GO:0030968)2.55777216
84nuclear envelope reassembly (GO:0031468)2.55728734
85mitotic nuclear envelope reassembly (GO:0007084)2.55728734
86DNA strand elongation (GO:0022616)2.55523149
87mitotic G1 DNA damage checkpoint (GO:0031571)2.54895247
88intracellular estrogen receptor signaling pathway (GO:0030520)2.52790459
89DNA strand elongation involved in DNA replication (GO:0006271)2.51036506
90histone phosphorylation (GO:0016572)2.51018214
91DNA topological change (GO:0006265)2.50665829
92ribosome biogenesis (GO:0042254)2.50622687
93ER-nucleus signaling pathway (GO:0006984)2.48120344
94embryonic process involved in female pregnancy (GO:0060136)2.48014863
95protein hydroxylation (GO:0018126)2.47414636
96mitotic sister chromatid cohesion (GO:0007064)2.47054904
97protein localization to chromosome, centromeric region (GO:0071459)2.46010086
98regulation of nuclease activity (GO:0032069)2.45210896
99adenine nucleotide transport (GO:0051503)2.45144072
100peptidyl-arginine methylation (GO:0018216)2.44572979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06777931
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.10501136
3MYC_22102868_ChIP-Seq_BL_Human3.04689788
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.93971348
5VDR_21846776_ChIP-Seq_THP-1_Human2.67879371
6ZNF263_19887448_ChIP-Seq_K562_Human2.49231732
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45555414
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35659965
9LXR_22292898_ChIP-Seq_THP-1_Human2.31908218
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.30438849
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28637772
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24264824
13DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.23284245
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.13699258
15RACK7_27058665_Chip-Seq_MCF-7_Human2.12364031
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05680970
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04215097
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01923906
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.98599693
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93032633
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82911898
22XRN2_22483619_ChIP-Seq_HELA_Human1.81205687
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79268405
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75257598
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74725130
26TCF7_22412390_ChIP-Seq_EML_Mouse1.69028746
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68557857
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63310583
29KDM2B_26808549_Chip-Seq_DND41_Human1.61342357
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60877693
31CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.59798216
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57398348
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56126048
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54120744
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53393247
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51172705
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50072749
38ATF3_27146783_Chip-Seq_COLON_Human1.49663594
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49520713
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47015268
41P68_20966046_ChIP-Seq_HELA_Human1.44251239
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43576896
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.42711259
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41886895
45KDM2B_26808549_Chip-Seq_K562_Human1.40754630
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39090198
47DCP1A_22483619_ChIP-Seq_HELA_Human1.34087496
48AR_21909140_ChIP-Seq_LNCAP_Human1.34000667
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33673035
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33650225
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32638700
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30995329
53CLOCK_20551151_ChIP-Seq_293T_Human1.30879134
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30459906
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30200584
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29982967
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29653874
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29456755
59NCOR1_26117541_ChIP-Seq_K562_Human1.29073425
60SMC4_20622854_ChIP-Seq_HELA_Human1.28746137
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27113964
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.26125400
63TP53_22127205_ChIP-Seq_IMR90_Human1.25510337
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23227718
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21838415
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.21770814
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21601282
68CREB1_26743006_Chip-Seq_LNCaP_Human1.21074673
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19949394
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.19307199
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18648529
72MAF_26560356_Chip-Seq_TH2_Human1.18450722
73MAF_26560356_Chip-Seq_TH1_Human1.18177420
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17786945
75KDM5A_27292631_Chip-Seq_BREAST_Human1.17719596
76CHD1_26751641_Chip-Seq_LNCaP_Human1.17543600
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17457303
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.17332092
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17157781
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16526293
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.15829503
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.14382315
83VDR_24763502_ChIP-Seq_THP-1_Human1.14269386
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11168389
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.10988678
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06788558
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04813694
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.04757765
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04176109
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03211247
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03114684
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02047816
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01474155
94TFEB_21752829_ChIP-Seq_HELA_Human1.01029810
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98199915
96TTF2_22483619_ChIP-Seq_HELA_Human0.98091558
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97706690
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97659727
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.97206822
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95550589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.08603566
2MP0005451_abnormal_body_composition3.32224069
3MP0005076_abnormal_cell_differentiation3.00253186
4MP0010234_abnormal_vibrissa_follicle2.94311558
5MP0002877_abnormal_melanocyte_morpholog2.82424296
6MP0003111_abnormal_nucleus_morphology2.65453188
7MP0004233_abnormal_muscle_weight2.62326472
8MP0001348_abnormal_lacrimal_gland2.59154318
9MP0008438_abnormal_cutaneous_collagen2.37172973
10MP0003566_abnormal_cell_adhesion2.35442864
11MP0005409_darkened_coat_color2.32240299
12MP0003693_abnormal_embryo_hatching2.21965825
13MP0004185_abnormal_adipocyte_glucose2.12160351
14MP0004957_abnormal_blastocyst_morpholog2.08027672
15MP0010094_abnormal_chromosome_stability2.06967306
16MP0000537_abnormal_urethra_morphology1.93769555
17MP0003077_abnormal_cell_cycle1.90972789
18MP0000003_abnormal_adipose_tissue1.81358203
19MP0005257_abnormal_intraocular_pressure1.75287123
20MP0001849_ear_inflammation1.72723789
21MP0005501_abnormal_skin_physiology1.72375815
22MP0005623_abnormal_meninges_morphology1.72272681
23MP0003091_abnormal_cell_migration1.71988186
24MP0003453_abnormal_keratinocyte_physiol1.71162836
25MP0010352_gastrointestinal_tract_polyps1.69594923
26MP0002796_impaired_skin_barrier1.66841363
27MP0001730_embryonic_growth_arrest1.65590963
28MP0000350_abnormal_cell_proliferation1.54891521
29MP0002060_abnormal_skin_morphology1.53788249
30MP0004808_abnormal_hematopoietic_stem1.45872121
31MP0005058_abnormal_lysosome_morphology1.44895860
32MP0009053_abnormal_anal_canal1.44891575
33MP0000678_abnormal_parathyroid_gland1.44379829
34MP0008932_abnormal_embryonic_tissue1.43989096
35MP0000733_abnormal_muscle_development1.43562232
36MP0002396_abnormal_hematopoietic_system1.43038301
37MP0008057_abnormal_DNA_replication1.35580269
38MP0002080_prenatal_lethality1.34478569
39MP0000579_abnormal_nail_morphology1.34164578
40MP0001661_extended_life_span1.31653951
41MP0003984_embryonic_growth_retardation1.30911400
42MP0005380_embryogenesis_phenotype1.30438728
43MP0001672_abnormal_embryogenesis/_devel1.30438728
44MP0002009_preneoplasia1.27981265
45MP0002086_abnormal_extraembryonic_tissu1.26007367
46MP0004858_abnormal_nervous_system1.25070664
47MP0000467_abnormal_esophagus_morphology1.23127718
48MP0002088_abnormal_embryonic_growth/wei1.22676757
49MP0005375_adipose_tissue_phenotype1.22167033
50MP0000751_myopathy1.19806840
51MP0004272_abnormal_basement_membrane1.19705662
52MP0005621_abnormal_cell_physiology1.16544913
53MP0005083_abnormal_biliary_tract1.16534934
54MP0005666_abnormal_adipose_tissue1.12690095
55MP0008007_abnormal_cellular_replicative1.10142660
56MP0001216_abnormal_epidermal_layer1.08867624
57MP0001697_abnormal_embryo_size1.08657802
58MP0005171_absent_coat_pigmentation1.08556842
59MP0010307_abnormal_tumor_latency1.05285814
60MP0009672_abnormal_birth_weight1.03457616
61MP0000759_abnormal_skeletal_muscle1.01394889
62MP0002249_abnormal_larynx_morphology1.01387226
63MP0004197_abnormal_fetal_growth/weight/1.01237877
64MP0002085_abnormal_embryonic_tissue0.99968018
65MP0003115_abnormal_respiratory_system0.98450030
66MP0000762_abnormal_tongue_morphology0.97266661
67MP0002089_abnormal_postnatal_growth/wei0.96624879
68MP0000747_muscle_weakness0.96275850
69MP0010030_abnormal_orbit_morphology0.95812359
70MP0000013_abnormal_adipose_tissue0.93181153
71MP0002084_abnormal_developmental_patter0.92182013
72MP0000313_abnormal_cell_death0.89782888
73MP0009931_abnormal_skin_appearance0.89143376
74MP0004087_abnormal_muscle_fiber0.88668790
75MP0004782_abnormal_surfactant_physiolog0.87959779
76MP0000534_abnormal_ureter_morphology0.86905661
77MP0005023_abnormal_wound_healing0.86757583
78MP0003942_abnormal_urinary_system0.85330083
79MP0000428_abnormal_craniofacial_morphol0.84550349
80MP0005384_cellular_phenotype0.84436959
81MP0010771_integument_phenotype0.84189078
82MP0010630_abnormal_cardiac_muscle0.84169613
83MP0003385_abnormal_body_wall0.83854947
84MP0001873_stomach_inflammation0.83850256
85MP0001243_abnormal_dermal_layer0.81346672
86MP0000377_abnormal_hair_follicle0.81011093
87MP0008260_abnormal_autophagy0.80700221
88MP0002896_abnormal_bone_mineralization0.80560341
89MP0009840_abnormal_foam_cell0.80273672
90MP0001958_emphysema0.79921006
91MP0000490_abnormal_crypts_of0.78764925
92MP0000858_altered_metastatic_potential0.78352979
93MP0002098_abnormal_vibrissa_morphology0.78077224
94MP0002697_abnormal_eye_size0.75849964
95MP0003315_abnormal_perineum_morphology0.73435683
96MP0003959_abnormal_lean_body0.73303707
97MP0002970_abnormal_white_adipose0.73164449
98MP0000462_abnormal_digestive_system0.72815752
99MP0004264_abnormal_extraembryonic_tissu0.72534519
100MP0001340_abnormal_eyelid_morphology0.72212423

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)3.97231713
2Hyperacusis (HP:0010780)3.88732269
3Premature rupture of membranes (HP:0001788)3.48067991
4Broad face (HP:0000283)3.34162135
5Protrusio acetabuli (HP:0003179)3.30353475
6Thin bony cortex (HP:0002753)3.11398161
7Asymmetry of the thorax (HP:0001555)2.79730510
8Achilles tendon contracture (HP:0001771)2.72924560
9Progressive muscle weakness (HP:0003323)2.70108784
10Ankyloglossia (HP:0010296)2.64143698
11Insomnia (HP:0100785)2.56625508
12Short nail (HP:0001799)2.52374056
13Distal lower limb amyotrophy (HP:0008944)2.50575972
14Abnormality of oral frenula (HP:0000190)2.47380973
15Abnormality of the Achilles tendon (HP:0005109)2.40791091
16Fragile skin (HP:0001030)2.39977622
17Vertebral compression fractures (HP:0002953)2.38890106
18Abnormality of the distal phalanx of the thumb (HP:0009617)2.38508376
19Sparse lateral eyebrow (HP:0005338)2.37942493
20Poikiloderma (HP:0001029)2.28778675
21Flat acetabular roof (HP:0003180)2.28316229
22Increased connective tissue (HP:0009025)2.28313705
23Cervical subluxation (HP:0003308)2.23858489
24Disproportionate tall stature (HP:0001519)2.23826348
25Elbow flexion contracture (HP:0002987)2.23453381
26Turricephaly (HP:0000262)2.20777475
27Dysmetric saccades (HP:0000641)2.19714599
28Trismus (HP:0000211)2.17045815
29Bowing of the arm (HP:0006488)2.16154883
30Bowed forearm bones (HP:0003956)2.16154883
31Insidious onset (HP:0003587)2.09552662
32Termporal pattern (HP:0011008)2.09552662
33Long palpebral fissure (HP:0000637)2.09124663
34Distal upper limb amyotrophy (HP:0007149)2.08448028
35Upper limb amyotrophy (HP:0009129)2.08448028
36Patellar dislocation (HP:0002999)2.08371809
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.07280064
38Osteolytic defects of the hand bones (HP:0009699)2.07280064
39Selective tooth agenesis (HP:0001592)2.07214950
40Deviation of the thumb (HP:0009603)2.05900801
41Abnormal ossification of hand bones (HP:0005921)2.05075837
42Squamous cell carcinoma (HP:0002860)2.02841998
43Shallow orbits (HP:0000586)2.02521827
44Atrophic scars (HP:0001075)2.02168289
45Cerebral aneurysm (HP:0004944)2.01490292
46Testicular atrophy (HP:0000029)1.99749390
47Ankle contracture (HP:0006466)1.96875762
48Advanced eruption of teeth (HP:0006288)1.95580313
49Natal tooth (HP:0000695)1.95496230
50Abnormality of the distal phalanges of the toes (HP:0010182)1.93383666
51Mitral regurgitation (HP:0001653)1.89478920
52Spinal rigidity (HP:0003306)1.89463489
53Elfin facies (HP:0004428)1.88557529
54Progressive external ophthalmoplegia (HP:0000590)1.87585720
55Wormian bones (HP:0002645)1.87535737
56Bladder diverticulum (HP:0000015)1.86682736
57Urethral obstruction (HP:0000796)1.85052552
58Proximal placement of thumb (HP:0009623)1.84319528
59Spinal cord lesions (HP:0100561)1.84060129
60Syringomyelia (HP:0003396)1.84060129
61Abnormality of the calcaneus (HP:0008364)1.81374168
62Renal duplication (HP:0000075)1.81279101
63Reticulocytosis (HP:0001923)1.79995981
64Thin ribs (HP:0000883)1.79935509
65Overriding aorta (HP:0002623)1.78839015
66Biconcave vertebral bodies (HP:0004586)1.78553838
67Blue sclerae (HP:0000592)1.78450278
68Back pain (HP:0003418)1.75710509
69Spinal cord compression (HP:0002176)1.74293116
70Relative macrocephaly (HP:0004482)1.73112734
71Generalized amyotrophy (HP:0003700)1.72018603
72Pointed chin (HP:0000307)1.69976680
73Unilateral renal agenesis (HP:0000122)1.69546131
74Breast hypoplasia (HP:0003187)1.69342854
75Genu recurvatum (HP:0002816)1.68933435
76Abnormality of the tricuspid valve (HP:0001702)1.68844226
77Premature skin wrinkling (HP:0100678)1.68568101
78Entropion (HP:0000621)1.68567094
79Mildly elevated creatine phosphokinase (HP:0008180)1.66967542
80Lower limb amyotrophy (HP:0007210)1.66902385
81Ragged-red muscle fibers (HP:0003200)1.66793194
82Dislocated radial head (HP:0003083)1.65398995
83Missing ribs (HP:0000921)1.65065470
84Arterial tortuosity (HP:0005116)1.63633080
85Abnormality of the thoracic spine (HP:0100711)1.63510720
86Broad distal phalanx of finger (HP:0009836)1.62515751
87Abnormality of the umbilical cord (HP:0010881)1.61529409
88Difficulty climbing stairs (HP:0003551)1.61471074
89Microvesicular hepatic steatosis (HP:0001414)1.59779924
90Centrally nucleated skeletal muscle fibers (HP:0003687)1.58973642
91Congenital hip dislocation (HP:0001374)1.57503647
92Abnormality of carpal bone ossification (HP:0006257)1.57372531
93Facial hemangioma (HP:0000329)1.56737192
94Distal lower limb muscle weakness (HP:0009053)1.56673109
95Heterotopia (HP:0002282)1.56485221
96Deep philtrum (HP:0002002)1.56162431
97Progressive hearing impairment (HP:0001730)1.55976686
98Abnormality of the acetabulum (HP:0003170)1.55282381
99Glossoptosis (HP:0000162)1.55189917
100Spina bifida occulta (HP:0003298)1.55114632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.96291071
2ICK3.62854110
3SMG13.51946878
4IRAK33.50552068
5EEF2K3.39901723
6CDK123.21761369
7SIK12.70464029
8MST1R2.67285552
9PRPF4B2.56860415
10MAP3K102.15352590
11TTN2.14831752
12NME22.13381239
13EPHA22.11840394
14PKN21.74863432
15ERN11.71893047
16SCYL21.68367347
17LATS21.65682470
18PIM21.56891973
19PDGFRA1.54222409
20MTOR1.51624026
21MET1.36820815
22PAK41.35544685
23RPS6KB21.30616069
24PRKD31.25891946
25ARAF1.25561887
26TESK21.19102120
27RIPK11.18968011
28TESK11.16686217
29IRAK21.14678206
30MAP2K31.10116077
31CDK71.06427367
32CDK41.06264619
33MAPK111.01467777
34PTK21.01331482
35NTRK10.97810506
36CAMK1D0.97224116
37MAP3K80.95544437
38KSR20.94952683
39CDK80.93973883
40LMTK20.90744971
41BRD40.87274076
42PAK20.86650436
43RAF10.86290803
44TAOK20.84357709
45PDPK10.83260820
46PBK0.81903493
47BUB10.81535744
48FGFR40.79409702
49RPS6KA20.78996114
50TTK0.78930481
51CDK60.75561860
52CHEK20.74991918
53MAP3K130.73938515
54MAP3K90.73858941
55BRAF0.72556217
56EIF2AK10.68506060
57MAP2K20.68343160
58TSSK60.68146210
59CAMK1G0.67962872
60DDR20.67684363
61NEK90.64818499
62PTK60.63559130
63PRKD20.63271456
64CHEK10.62668162
65RPS6KL10.62365052
66RPS6KC10.62365052
67AURKA0.62086588
68CDC70.60085243
69MARK20.59240202
70ILK0.56340095
71BMX0.54336749
72ERBB40.54268619
73LRRK20.54087283
74AKT20.53270107
75SRPK10.48504020
76PRKCI0.47137966
77STK380.46624523
78MELK0.45619548
79AURKB0.45331359
80RPS6KA40.43124444
81NEK20.43061154
82MAP3K140.42517856
83CDK20.41168249
84MAP2K10.40683756
85ATR0.39934298
86BRSK10.39876634
87SIK20.39497051
88CDK10.39229864
89RPS6KA60.39041904
90PASK0.38926422
91PDK20.37094067
92CDC42BPA0.36910693
93RPS6KA10.36093381
94CLK10.35398996
95MAP3K10.35268312
96CDK90.34785948
97IRAK40.34106620
98LATS10.33252879
99NEK60.33133165
100RET0.32746218

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.27426693
2DNA replication_Homo sapiens_hsa030302.14890858
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12979573
4Central carbon metabolism in cancer_Homo sapiens_hsa052302.06998935
5Bladder cancer_Homo sapiens_hsa052191.99591294
6Non-small cell lung cancer_Homo sapiens_hsa052231.79554722
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.75806937
8Thyroid cancer_Homo sapiens_hsa052161.75616143
9Sulfur relay system_Homo sapiens_hsa041221.75417285
10Biosynthesis of amino acids_Homo sapiens_hsa012301.74821110
11Fructose and mannose metabolism_Homo sapiens_hsa000511.71667684
12Small cell lung cancer_Homo sapiens_hsa052221.67537756
13Acute myeloid leukemia_Homo sapiens_hsa052211.65208783
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61970097
15Cell cycle_Homo sapiens_hsa041101.61465981
16Pancreatic cancer_Homo sapiens_hsa052121.57487741
17Pentose phosphate pathway_Homo sapiens_hsa000301.57320966
18Endometrial cancer_Homo sapiens_hsa052131.52559057
19Other glycan degradation_Homo sapiens_hsa005111.50640820
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48789937
21VEGF signaling pathway_Homo sapiens_hsa043701.43546357
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42498441
23mRNA surveillance pathway_Homo sapiens_hsa030151.41108460
24mTOR signaling pathway_Homo sapiens_hsa041501.39781330
25MicroRNAs in cancer_Homo sapiens_hsa052061.38347098
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35425698
27Notch signaling pathway_Homo sapiens_hsa043301.33120329
28Lysine degradation_Homo sapiens_hsa003101.32283480
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30343236
30RNA transport_Homo sapiens_hsa030131.30133798
31Vitamin B6 metabolism_Homo sapiens_hsa007501.29358188
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27857100
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24714726
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24607622
35Glioma_Homo sapiens_hsa052141.21241411
36Focal adhesion_Homo sapiens_hsa045101.19068606
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.18123522
38ErbB signaling pathway_Homo sapiens_hsa040121.17304432
39Base excision repair_Homo sapiens_hsa034101.17033373
40Proteoglycans in cancer_Homo sapiens_hsa052051.15336591
41Prostate cancer_Homo sapiens_hsa052151.14779898
42Renal cell carcinoma_Homo sapiens_hsa052111.12502563
43Spliceosome_Homo sapiens_hsa030401.11870639
44N-Glycan biosynthesis_Homo sapiens_hsa005101.11785443
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10733283
46Insulin signaling pathway_Homo sapiens_hsa049101.09502150
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03705344
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.02649952
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02300028
50One carbon pool by folate_Homo sapiens_hsa006701.01803269
51Colorectal cancer_Homo sapiens_hsa052100.98348414
52Prion diseases_Homo sapiens_hsa050200.97543946
53ECM-receptor interaction_Homo sapiens_hsa045120.96436106
54Viral carcinogenesis_Homo sapiens_hsa052030.94539854
55Carbon metabolism_Homo sapiens_hsa012000.94384512
56AMPK signaling pathway_Homo sapiens_hsa041520.93368357
57Adherens junction_Homo sapiens_hsa045200.92552850
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92536371
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92461967
60Nucleotide excision repair_Homo sapiens_hsa034200.90043683
61Inositol phosphate metabolism_Homo sapiens_hsa005620.88209638
62Hippo signaling pathway_Homo sapiens_hsa043900.88120619
63Hepatitis B_Homo sapiens_hsa051610.82088310
64Apoptosis_Homo sapiens_hsa042100.81961922
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81799929
66HTLV-I infection_Homo sapiens_hsa051660.80195336
67Galactose metabolism_Homo sapiens_hsa000520.79960519
68B cell receptor signaling pathway_Homo sapiens_hsa046620.78332347
69Estrogen signaling pathway_Homo sapiens_hsa049150.78056285
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76396021
71Pyrimidine metabolism_Homo sapiens_hsa002400.75638680
72Melanoma_Homo sapiens_hsa052180.75251500
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73509199
74Prolactin signaling pathway_Homo sapiens_hsa049170.67657304
75Insulin resistance_Homo sapiens_hsa049310.67081717
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66337649
77Shigellosis_Homo sapiens_hsa051310.64334039
78GnRH signaling pathway_Homo sapiens_hsa049120.62794751
79Pathways in cancer_Homo sapiens_hsa052000.61082065
80Endocytosis_Homo sapiens_hsa041440.61000069
81Arginine biosynthesis_Homo sapiens_hsa002200.59860463
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58148505
83Choline metabolism in cancer_Homo sapiens_hsa052310.57410564
84Hepatitis C_Homo sapiens_hsa051600.57192848
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57085583
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.57036733
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56239994
88Basal cell carcinoma_Homo sapiens_hsa052170.56156980
89Mismatch repair_Homo sapiens_hsa034300.55056904
90Glucagon signaling pathway_Homo sapiens_hsa049220.53262689
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.52837267
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.50229024
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49458938
94TGF-beta signaling pathway_Homo sapiens_hsa043500.48836918
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48796496
96Pyruvate metabolism_Homo sapiens_hsa006200.48099973
97Fatty acid biosynthesis_Homo sapiens_hsa000610.47941396
98Hedgehog signaling pathway_Homo sapiens_hsa043400.47764052
99Non-homologous end-joining_Homo sapiens_hsa034500.47703498
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.47540495

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