TSSK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.41030038
2plasma membrane fusion (GO:0045026)9.06072046
3multicellular organism reproduction (GO:0032504)9.05376807
4motile cilium assembly (GO:0044458)8.81771209
5axonemal dynein complex assembly (GO:0070286)8.62699274
6epithelial cilium movement (GO:0003351)8.48672485
7response to pheromone (GO:0019236)8.33836153
8regulation of cilium movement (GO:0003352)8.09864695
9reproduction (GO:0000003)8.00890217
10phosphatidylethanolamine biosynthetic process (GO:0006646)7.28658576
11rRNA methylation (GO:0031167)7.26072499
12organic cation transport (GO:0015695)7.16267276
13negative regulation of inclusion body assembly (GO:0090084)6.88330289
14spermatogenesis (GO:0007283)6.72015303
15phosphatidylethanolamine metabolic process (GO:0046337)6.71479112
16male gamete generation (GO:0048232)6.69663784
17cilium movement (GO:0003341)6.69372152
18sperm capacitation (GO:0048240)6.69119564
19protein targeting to Golgi (GO:0000042)6.67488017
20chromosome condensation (GO:0030261)6.56319605
21synaptonemal complex organization (GO:0070193)6.49236849
22synaptonemal complex assembly (GO:0007130)6.47658657
23cilium or flagellum-dependent cell motility (GO:0001539)6.40734853
24establishment of protein localization to Golgi (GO:0072600)6.39278269
25single fertilization (GO:0007338)6.39058161
26centriole replication (GO:0007099)6.36622512
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.21739399
28gamete generation (GO:0007276)6.15213350
29rRNA modification (GO:0000154)6.11663128
30microtubule depolymerization (GO:0007019)6.01870663
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.98978875
32male meiosis (GO:0007140)5.92241827
33regulation of inclusion body assembly (GO:0090083)5.89988948
34centriole assembly (GO:0098534)5.62279977
35piRNA metabolic process (GO:0034587)5.59250971
36fertilization (GO:0009566)5.58095802
37* DNA packaging (GO:0006323)5.47350487
38cellular ketone body metabolic process (GO:0046950)5.43425224
39germ cell development (GO:0007281)5.24325125
40positive regulation of Rab GTPase activity (GO:0032851)5.22990452
41regulation of Rab GTPase activity (GO:0032313)5.22990452
42calcium ion-dependent exocytosis (GO:0017156)5.17740036
43* cellular process involved in reproduction in multicellular organism (GO:0022412)5.09660051
44spermatid nucleus differentiation (GO:0007289)5.01791281
45glycerol ether metabolic process (GO:0006662)4.96470515
46sequestering of actin monomers (GO:0042989)4.88983895
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87728010
48protein localization to Golgi apparatus (GO:0034067)4.81223767
49multicellular organismal reproductive process (GO:0048609)4.80668352
50ketone body metabolic process (GO:1902224)4.76893267
51regulation of microtubule-based movement (GO:0060632)4.70693139
52cell recognition (GO:0008037)4.69438664
53seminiferous tubule development (GO:0072520)4.66290891
54microtubule severing (GO:0051013)4.65270213
55regulation of transcription involved in cell fate commitment (GO:0060850)4.61056834
56ether metabolic process (GO:0018904)4.56920968
57chromosome organization involved in meiosis (GO:0070192)4.42140988
58ventricular system development (GO:0021591)4.38895155
59male meiosis I (GO:0007141)4.37521016
60regulation of centriole replication (GO:0046599)4.35334208
61sexual reproduction (GO:0019953)4.35187153
62single strand break repair (GO:0000012)4.28260698
63left/right pattern formation (GO:0060972)4.09086524
64chaperone-mediated protein complex assembly (GO:0051131)4.07211850
65RNA destabilization (GO:0050779)3.95127362
66meiotic nuclear division (GO:0007126)3.91900884
67polyamine biosynthetic process (GO:0006596)3.89061320
68RNA localization (GO:0006403)3.85360665
69* multicellular organismal development (GO:0007275)3.76960976
70regulation of spindle checkpoint (GO:0090231)3.74344899
71musculoskeletal movement (GO:0050881)3.72645529
72multicellular organismal movement (GO:0050879)3.72645529
73interferon-gamma secretion (GO:0072643)3.69903593
74meiosis I (GO:0007127)3.63474030
75regulation of interleukin-13 production (GO:0032656)3.62662114
76DNA methylation involved in gamete generation (GO:0043046)3.60529809
77homeostasis of number of cells within a tissue (GO:0048873)3.60140380
78regulation of T-helper 2 cell differentiation (GO:0045628)3.57682038
79response to acidic pH (GO:0010447)3.49828823
80positive regulation of macrophage activation (GO:0043032)3.49018983
81peptidyl-threonine dephosphorylation (GO:0035970)3.47662553
82negative regulation of Rho protein signal transduction (GO:0035024)3.44441461
83nucleus organization (GO:0006997)3.41564622
84nucleosome disassembly (GO:0006337)3.40188111
85protein-DNA complex disassembly (GO:0032986)3.40188111
86protein polyglutamylation (GO:0018095)3.35935124
87genitalia morphogenesis (GO:0035112)3.35930201
88DNA deamination (GO:0045006)3.32210231
89coenzyme catabolic process (GO:0009109)3.31204934
90cellular response to pH (GO:0071467)3.30786357
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.30143655
92protein refolding (GO:0042026)3.28877954
93meiotic cell cycle (GO:0051321)3.28405071
94cerebral cortex neuron differentiation (GO:0021895)3.27754219
95chromatin silencing (GO:0006342)3.26018732
96microtubule nucleation (GO:0007020)3.24843917
97regulation of somitogenesis (GO:0014807)3.24393328
98histone H3-K9 demethylation (GO:0033169)3.18069093
99mitotic sister chromatid cohesion (GO:0007064)3.17448434
100glomerular visceral epithelial cell development (GO:0072015)3.15737836
101mitotic G1 DNA damage checkpoint (GO:0031571)3.08144165
102glomerular epithelial cell development (GO:0072310)3.06582405
103protein complex localization (GO:0031503)3.06528939
104mitochondrial fission (GO:0000266)3.03722380
105protein localization to chromosome, centromeric region (GO:0071459)2.99099701
106negative regulation of histone methylation (GO:0031061)2.98918881
107protein depolymerization (GO:0051261)2.98098201
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.95917239
109antigen processing and presentation via MHC class Ib (GO:0002475)2.87558367
110glycolytic process (GO:0006096)2.87295349
111mitochondrion degradation (GO:0000422)2.87153165
112regulation of phosphoprotein phosphatase activity (GO:0043666)2.85929035
113positive regulation of histone deacetylation (GO:0031065)2.85182841
114amino-acid betaine transport (GO:0015838)2.84856882
115carnitine transport (GO:0015879)2.84856882
116microtubule polymerization or depolymerization (GO:0031109)2.83308906
117regulation of cilium assembly (GO:1902017)2.82470623
118cranial nerve morphogenesis (GO:0021602)2.81832372
119negative regulation of gene expression, epigenetic (GO:0045814)2.81236906
120receptor recycling (GO:0001881)2.80959926
121regulation of ARF GTPase activity (GO:0032312)2.80510374
122meiotic cell cycle process (GO:1903046)2.77590707
123regulation of interleukin-5 production (GO:0032674)2.76763044
124protein K11-linked deubiquitination (GO:0035871)2.76742302
125monoubiquitinated protein deubiquitination (GO:0035520)2.76329098
126histone exchange (GO:0043486)2.76137303
127nucleoside diphosphate phosphorylation (GO:0006165)2.68746969
128membrane protein intracellular domain proteolysis (GO:0031293)2.68432095
129GTP biosynthetic process (GO:0006183)2.64956893
130carnitine transmembrane transport (GO:1902603)2.63723345
131synapsis (GO:0007129)2.59631559
132cellular response to arsenic-containing substance (GO:0071243)2.55631701
133DNA replication-dependent nucleosome assembly (GO:0006335)2.54900347
134DNA replication-dependent nucleosome organization (GO:0034723)2.54900347
135amine biosynthetic process (GO:0009309)2.53527712
136cellular biogenic amine biosynthetic process (GO:0042401)2.53527712
137protein localization to cilium (GO:0061512)2.52360239
138sperm motility (GO:0030317)13.4169650
139cell wall macromolecule catabolic process (GO:0016998)12.8133680
140cell wall macromolecule metabolic process (GO:0044036)12.8133680
141acrosome reaction (GO:0007340)12.2194991
142fusion of sperm to egg plasma membrane (GO:0007342)12.0655278
143sperm-egg recognition (GO:0035036)11.3828241
144binding of sperm to zona pellucida (GO:0007339)10.6591584
145acrosome assembly (GO:0001675)10.6285787
146cell-cell recognition (GO:0009988)10.2165756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.77452529
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36179958
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61225111
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.02708030
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97068927
6EZH2_22144423_ChIP-Seq_EOC_Human2.82292921
7* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.74227533
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63691496
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55687518
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.41872808
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.33953311
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.11650767
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11650767
14ERA_21632823_ChIP-Seq_H3396_Human2.07243802
15LXR_22292898_ChIP-Seq_THP-1_Human2.05313023
16FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03088326
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00525711
18CTCF_27219007_Chip-Seq_Bcells_Human1.99391713
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96066652
20DROSHA_22980978_ChIP-Seq_HELA_Human1.90488092
21VDR_22108803_ChIP-Seq_LS180_Human1.89284484
22GATA3_21867929_ChIP-Seq_CD8_Mouse1.85349545
23FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.81489032
24SOX2_22085726_ChIP-Seq_NPCs_Mouse1.81023469
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78012227
26TAF2_19829295_ChIP-Seq_ESCs_Human1.74145186
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73118402
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70558040
29TP63_22573176_ChIP-Seq_HFKS_Human1.70049633
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.66200433
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63913037
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62777815
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62705348
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.62328239
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62201203
36ZNF274_21170338_ChIP-Seq_K562_Hela1.61254402
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60624399
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58317505
39SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.55134204
40OCT4_20526341_ChIP-Seq_ESCs_Human1.54332339
41MYC_19829295_ChIP-Seq_ESCs_Human1.51578496
42SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50820800
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50618488
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50433940
45STAT1_17558387_ChIP-Seq_HELA_Human1.49313531
46P53_21459846_ChIP-Seq_SAOS-2_Human1.47426936
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46601737
48* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.46192828
49CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45754895
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45493129
51SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44603116
52P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.43504182
53ER_23166858_ChIP-Seq_MCF-7_Human1.42990419
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.41294759
55SA1_27219007_Chip-Seq_Bcells_Human1.41157558
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40233079
57CEBPB_22108803_ChIP-Seq_LS180_Human1.36377779
58RUNX_20019798_ChIP-Seq_JUKART_Human1.35722362
59BCOR_27268052_Chip-Seq_Bcells_Human1.35446862
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34330950
61RXRA_24833708_ChIP-Seq_LIVER_Mouse1.34167759
62BCL6_27268052_Chip-Seq_Bcells_Human1.33003909
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.33000769
64RARA_24833708_ChIP-Seq_LIVER_Mouse1.32071280
65* ELF1_20517297_ChIP-Seq_JURKAT_Human1.31845766
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.31311729
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.31239791
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29062928
69CTCF_20526341_ChIP-Seq_ESCs_Human1.28022698
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27580856
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27245874
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26103554
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.24610247
74SPI1_26923725_Chip-Seq_HPCs_Mouse1.24213906
75* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24065598
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24028281
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23676979
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22651374
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22467175
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22288130
81RBPJ_21746931_ChIP-Seq_IB4_Human1.22235551
82HNFA_21074721_ChIP-Seq_CACO-2_Human1.22235352
83ERG_20517297_ChIP-Seq_VCAP_Human1.22098618
84GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21923885
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.21054752
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20989541
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20878265
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.20834959
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.20377824
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19840610
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19812343
92CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18970571
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18679185
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.18082398
95* PHF8_20622854_ChIP-Seq_HELA_Human1.17027680
96FUS_26573619_Chip-Seq_HEK293_Human1.17024352
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15706894
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15054381
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.14811976
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14666209
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.13373294
102ETV1_20927104_ChIP-Seq_GIST48_Human1.11863977
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11850990
104GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11841707
105FOXM1_23109430_ChIP-Seq_U2OS_Human1.10938070
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10761708
107JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10326939
108LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10310952
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.09817917
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08552986
111AR_25329375_ChIP-Seq_VCAP_Human1.08140689
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07930389
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07062324
114CBP_20019798_ChIP-Seq_JUKART_Human1.07062324
115CTCF_21964334_Chip-Seq_Bcells_Human1.05512808
116* SMRT_27268052_Chip-Seq_Bcells_Human1.05199330
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.05099778
118KLF4_19829295_ChIP-Seq_ESCs_Human1.04888386
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04378825
120CSB_26484114_Chip-Seq_FIBROBLAST_Human1.04143102
121GATA1_19941826_ChIP-Seq_K562_Human1.04044095
122SOX11_22085726_ChIP-Seq_ESNs_Mouse1.04030764
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03034302
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02863105
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02798729
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02477529
127* OCT4_19829295_ChIP-Seq_ESCs_Human1.02383617
128FLI1_21867929_ChIP-Seq_CD8_Mouse1.02371528
129* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00933853
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00881611
131MYC_27129775_Chip-Seq_CORNEA_Mouse1.00423542
132TP53_18474530_ChIP-ChIP_U2OS_Human1.00218350
133* SPI1_20517297_ChIP-Seq_HL60_Human1.00122429
134GATA6_21074721_ChIP-Seq_CACO-2_Human0.99118679
135NFYB_21822215_ChIP-Seq_K562_Human0.98615965
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98017064
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97993804
138KLF5_25053715_ChIP-Seq_YYC3_Human0.97894971
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97415526
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97255793
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.95881182
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95497255
143NANOG_20526341_ChIP-Seq_ESCs_Human0.95466462
144GF1_26923725_Chip-Seq_HPCs_Mouse0.95443150
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94980916
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.94580994
147PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94399691
148SOX2_21211035_ChIP-Seq_LN229_Human0.93982899
149* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93225809
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92763262
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92634314
152RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92434898
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91324680
154STAT1_20625510_ChIP-Seq_HELA_Human0.89828691
155RAC3_21632823_ChIP-Seq_H3396_Human0.89302062
156* P300_27268052_Chip-Seq_Bcells_Human0.88830707
157ETS1_21867929_ChIP-Seq_TH2_Mouse0.88556363
158SMC4_20622854_ChIP-Seq_HELA_Human0.88329228
159TCF7_22412390_ChIP-Seq_EML_Mouse0.87962118
160E2F1_20622854_ChIP-Seq_HELA_Human0.87918018
161P68_20966046_ChIP-Seq_HELA_Human0.86584424
162EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86261281
163LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85862792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.57382223
2* MP0001929_abnormal_gametogenesis5.17087476
3MP0001348_abnormal_lacrimal_gland3.69871985
4MP0008877_abnormal_DNA_methylation3.49503328
5MP0002210_abnormal_sex_determination3.09731916
6* MP0002161_abnormal_fertility/fecundity3.03399079
7MP0005670_abnormal_white_adipose2.80930144
8MP0001145_abnormal_male_reproductive2.71431009
9MP0000678_abnormal_parathyroid_gland2.48369892
10MP0000653_abnormal_sex_gland2.31791763
11MP0005410_abnormal_fertilization16.2030355
12MP0003718_maternal_effect1.93937131
13MP0005451_abnormal_body_composition1.90688665
14MP0002160_abnormal_reproductive_system1.89696321
15MP0005083_abnormal_biliary_tract1.85740077
16MP0003646_muscle_fatigue1.77472512
17MP0005310_abnormal_salivary_gland1.69270965
18MP0005379_endocrine/exocrine_gland_phen1.63094386
19MP0002653_abnormal_ependyma_morphology1.60112761
20MP0004233_abnormal_muscle_weight1.49115912
21MP0002249_abnormal_larynx_morphology1.45385647
22MP0002822_catalepsy1.38414422
23MP0010094_abnormal_chromosome_stability1.34060000
24MP0005423_abnormal_somatic_nervous1.33575939
25MP0008058_abnormal_DNA_repair1.28488564
26MP0009053_abnormal_anal_canal1.26874203
27MP0003111_abnormal_nucleus_morphology1.26856236
28MP0001485_abnormal_pinna_reflex1.21989065
29MP0002138_abnormal_hepatobiliary_system1.19468733
30MP0003879_abnormal_hair_cell1.18761563
31MP0004742_abnormal_vestibular_system1.15642786
32MP0005397_hematopoietic_system_phenotyp1.10959748
33MP0001545_abnormal_hematopoietic_system1.10959748
34MP0001486_abnormal_startle_reflex1.08152342
35MP0005375_adipose_tissue_phenotype1.05716783
36MP0008961_abnormal_basal_metabolism1.02634090
37MP0008007_abnormal_cellular_replicative0.99340283
38MP0002127_abnormal_cardiovascular_syste0.98295296
39MP0004510_myositis0.98144253
40MP0002735_abnormal_chemical_nociception0.97741519
41MP0005395_other_phenotype0.93813490
42MP0001963_abnormal_hearing_physiology0.93507158
43MP0000003_abnormal_adipose_tissue0.93173934
44MP0005389_reproductive_system_phenotype0.93095237
45MP0003077_abnormal_cell_cycle0.91895433
46MP0001765_abnormal_ion_homeostasis0.90247603
47MP0006036_abnormal_mitochondrial_physio0.86827891
48MP0005248_abnormal_Harderian_gland0.86476364
49MP0003693_abnormal_embryo_hatching0.85599804
50MP0000358_abnormal_cell_content/0.84034856
51MP0008569_lethality_at_weaning0.83434661
52MP0002234_abnormal_pharynx_morphology0.83028614
53MP0000681_abnormal_thyroid_gland0.80953514
54MP0000026_abnormal_inner_ear0.80663377
55MP0002229_neurodegeneration0.78793560
56MP0001968_abnormal_touch/_nociception0.77503012
57MP0000955_abnormal_spinal_cord0.74680995
58MP0004859_abnormal_synaptic_plasticity0.74230315
59MP0004808_abnormal_hematopoietic_stem0.74016029
60MP0005636_abnormal_mineral_homeostasis0.73355239
61MP0002282_abnormal_trachea_morphology0.69437237
62MP0005367_renal/urinary_system_phenotyp0.69320114
63MP0000516_abnormal_urinary_system0.69320114
64MP0004957_abnormal_blastocyst_morpholog0.68318218
65MP0009278_abnormal_bone_marrow0.67381629
66MP0001730_embryonic_growth_arrest0.66251190
67MP0001835_abnormal_antigen_presentation0.63945862
68MP0005174_abnormal_tail_pigmentation0.63166597
69MP0001905_abnormal_dopamine_level0.61845340
70MP0000313_abnormal_cell_death0.61711853
71MP0002405_respiratory_system_inflammati0.60377081
72MP0003115_abnormal_respiratory_system0.60229441
73MP0002398_abnormal_bone_marrow0.60085350
74MP0001879_abnormal_lymphatic_vessel0.59325691
75MP0001293_anophthalmia0.58579279
76MP0002254_reproductive_system_inflammat0.58209190
77MP0010329_abnormal_lipoprotein_level0.55954568
78MP0006082_CNS_inflammation0.55595607
79MP0002067_abnormal_sensory_capabilities0.55214570
80MP0005167_abnormal_blood-brain_barrier0.55067924
81MP0005551_abnormal_eye_electrophysiolog0.54096896
82MP0001873_stomach_inflammation0.52824234
83MP0010307_abnormal_tumor_latency0.52748781
84MP0008057_abnormal_DNA_replication0.51547022
85MP0000249_abnormal_blood_vessel0.50980464
86MP0000685_abnormal_immune_system0.50946275
87MP0005666_abnormal_adipose_tissue0.50176076
88MP0001984_abnormal_olfaction0.49482718
89MP0002557_abnormal_social/conspecific_i0.48571169
90MP0001764_abnormal_homeostasis0.48107945
91MP0002269_muscular_atrophy0.47672200
92MP0002723_abnormal_immune_serum0.46890852
93MP0006035_abnormal_mitochondrial_morpho0.46833823
94MP0002132_abnormal_respiratory_system0.46754488
95MP0000703_abnormal_thymus_morphology0.46554109
96MP0003699_abnormal_female_reproductive0.44622178
97MP0003878_abnormal_ear_physiology0.44614972
98MP0005377_hearing/vestibular/ear_phenot0.44614972
99MP0000689_abnormal_spleen_morphology0.44574129
100MP0008995_early_reproductive_senescence0.43894637
101MP0005535_abnormal_body_temperature0.43665657
102MP0009764_decreased_sensitivity_to0.43598303
103MP0002429_abnormal_blood_cell0.43587006
104MP0000613_abnormal_salivary_gland0.43476545
105MP0001666_abnormal_nutrient_absorption0.43405717
106MP0000049_abnormal_middle_ear0.43111226
107MP0005647_abnormal_sex_gland0.42721950
108MP0002928_abnormal_bile_duct0.42076139
109MP0000716_abnormal_immune_system0.41920600
110MP0005253_abnormal_eye_physiology0.41281648
111MP0002080_prenatal_lethality0.41277558
112MP0005623_abnormal_meninges_morphology0.40970028
113MP0001324_abnormal_eye_pigmentation0.40799984
114MP0004085_abnormal_heartbeat0.40653828
115MP0002722_abnormal_immune_system0.40396839
116MP0000470_abnormal_stomach_morphology0.40178190
117MP0009785_altered_susceptibility_to0.40166189
118MP0005464_abnormal_platelet_physiology0.40059266
119MP0005365_abnormal_bile_salt0.39638578
120MP0005025_abnormal_response_to0.39484098
121MP0001697_abnormal_embryo_size0.39008388
122MP0003091_abnormal_cell_migration0.38745948
123MP0002420_abnormal_adaptive_immunity0.38692530
124MP0009333_abnormal_splenocyte_physiolog0.38487155
125MP0009115_abnormal_fat_cell0.38376746
126MP0003959_abnormal_lean_body0.38246523
127MP0003786_premature_aging0.38060461
128MP0001819_abnormal_immune_cell0.37797747
129MP0008932_abnormal_embryonic_tissue0.37021537
130MP0000350_abnormal_cell_proliferation0.36906357
131MP0000569_abnormal_digit_pigmentation0.36789948
132MP0002733_abnormal_thermal_nociception0.36504054
133MP0002019_abnormal_tumor_incidence0.36400342
134MP0005671_abnormal_response_to0.36331487
135MP0002452_abnormal_antigen_presenting0.36231597
136MP0001800_abnormal_humoral_immune0.35711295
137MP0003011_delayed_dark_adaptation0.35214636
138MP0003763_abnormal_thymus_physiology0.35161816
139MP0003172_abnormal_lysosome_physiology0.34811601
140MP0008874_decreased_physiological_sensi0.34654159
141MP0006054_spinal_hemorrhage0.34570502
142MP0002396_abnormal_hematopoietic_system0.34129101
143MP0004484_altered_response_of0.33847049
144MP0003656_abnormal_erythrocyte_physiolo0.33824631
145MP0003329_amyloid_beta_deposits0.33720613
146MP0001270_distended_abdomen0.33569535
147MP0005075_abnormal_melanosome_morpholog0.32832645
148MP0003806_abnormal_nucleotide_metabolis0.32210980
149MP0004133_heterotaxia0.32165631
150MP0000490_abnormal_crypts_of0.32005542
151MP0002971_abnormal_brown_adipose0.31647077
152MP0001672_abnormal_embryogenesis/_devel0.30660970
153MP0005380_embryogenesis_phenotype0.30660970
154MP0002169_no_abnormal_phenotype0.29830484
155MP0002873_normal_phenotype0.29392845
156MP0000858_altered_metastatic_potential0.29031957
157MP0008469_abnormal_protein_level0.28969482
158MP0002693_abnormal_pancreas_physiology0.28827883
159MP0000534_abnormal_ureter_morphology0.28405527
160MP0004036_abnormal_muscle_relaxation0.28372697
161MP0003183_abnormal_peptide_metabolism0.28356690
162MP0002168_other_aberrant_phenotype0.28344004
163MP0002572_abnormal_emotion/affect_behav0.28239519
164MP0002084_abnormal_developmental_patter0.27891135
165MP0003631_nervous_system_phenotype0.27824491
166MP0002970_abnormal_white_adipose0.27688375
167MP0005166_decreased_susceptibility_to0.26860057
168MP0003137_abnormal_impulse_conducting0.26856606

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.69440678
2Abnormal respiratory motile cilium morphology (HP:0005938)8.69440678
3Abnormal respiratory motile cilium physiology (HP:0012261)8.56052067
4Severe visual impairment (HP:0001141)8.40351826
5Chronic bronchitis (HP:0004469)7.23111134
6Rhinitis (HP:0012384)7.21497431
7Infertility (HP:0000789)7.15659313
8Nasal polyposis (HP:0100582)7.06465595
9Abnormal ciliary motility (HP:0012262)6.23446400
10Abnormality of the nasal mucosa (HP:0000433)5.82819309
11Bony spicule pigmentary retinopathy (HP:0007737)5.04652687
12Bronchitis (HP:0012387)5.03022429
13Attenuation of retinal blood vessels (HP:0007843)5.01403727
14Hyperkalemia (HP:0002153)4.88745031
15Resting tremor (HP:0002322)4.76782293
16Chronic hepatic failure (HP:0100626)4.68873640
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.64727927
18Male infertility (HP:0003251)4.61352502
19Bronchiectasis (HP:0002110)4.49810623
20Abnormal spermatogenesis (HP:0008669)4.11275534
21Nephronophthisis (HP:0000090)4.04026957
22Potter facies (HP:0002009)3.99413026
23Facial shape deformation (HP:0011334)3.99413026
24Abnormality of macular pigmentation (HP:0008002)3.95445836
25Cone-rod dystrophy (HP:0000548)3.80971363
26Abnormal rod and cone electroretinograms (HP:0008323)3.72529113
27Hypoplasia of the thymus (HP:0000778)3.66333030
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.65731935
29Recurrent bronchitis (HP:0002837)3.56296626
30Recurrent otitis media (HP:0000403)3.49317033
31Progressive sensorineural hearing impairment (HP:0000408)3.24739875
32Amelogenesis imperfecta (HP:0000705)3.23325426
33Hypoalphalipoproteinemia (HP:0003233)3.22329020
34Impulsivity (HP:0100710)3.21625725
35Unilateral renal agenesis (HP:0000122)3.15652396
36Enlarged epiphyses (HP:0010580)3.15376937
37Recurrent sinusitis (HP:0011108)3.12986112
38Cholecystitis (HP:0001082)3.03664276
39Abnormal gallbladder physiology (HP:0012438)3.03664276
40Hypoplastic ischia (HP:0003175)3.01827543
41Postural instability (HP:0002172)2.99615769
42Abnormality of the renal medulla (HP:0100957)2.89421350
43Menstrual irregularities (HP:0000858)2.85316792
44Abnormality of dental color (HP:0011073)2.79911878
45Renovascular hypertension (HP:0100817)2.77880803
46Abnormality of potassium homeostasis (HP:0011042)2.76116360
47Abnormality of the aortic arch (HP:0012303)2.71114293
48Generalized aminoaciduria (HP:0002909)2.69328306
49Abnormality of the ischium (HP:0003174)2.62520688
50Insulin-resistant diabetes mellitus (HP:0000831)2.60940050
51Tubular atrophy (HP:0000092)2.60099044
52Portal hypertension (HP:0001409)2.59821282
53Azoospermia (HP:0000027)2.55891439
54Abnormality of the costochondral junction (HP:0000919)2.49924116
55Progressive cerebellar ataxia (HP:0002073)2.43710338
56Abnormality of midbrain morphology (HP:0002418)2.43611407
57Molar tooth sign on MRI (HP:0002419)2.43611407
58Abnormality of the hepatic vasculature (HP:0006707)2.40744489
59Tubulointerstitial nephritis (HP:0001970)2.39558778
60Dyschromatopsia (HP:0007641)2.38327337
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.37919898
62Gonadotropin excess (HP:0000837)2.36116081
63Tubulointerstitial abnormality (HP:0001969)2.32918091
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31977987
65Flattened epiphyses (HP:0003071)2.31711459
66Abnormality of the parathyroid morphology (HP:0011766)2.30964652
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24484356
68Choroideremia (HP:0001139)2.19549779
69Widely patent fontanelles and sutures (HP:0004492)2.19449520
70Recurrent pneumonia (HP:0006532)2.18795110
71Progressive hearing impairment (HP:0001730)2.18072642
72Hyponatremia (HP:0002902)2.13984546
73Ventricular tachycardia (HP:0004756)2.12167295
74Flat capital femoral epiphysis (HP:0003370)2.10832253
75Hypophosphatemic rickets (HP:0004912)2.06967154
76Tubulointerstitial fibrosis (HP:0005576)2.06885817
77Tetany (HP:0001281)2.06764969
78Absent/shortened dynein arms (HP:0200106)12.3742410
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.3742410
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2122394
81Epiphyseal dysplasia (HP:0002656)1.99939695
82Increased purine levels (HP:0004368)1.98607647
83Hyperuricemia (HP:0002149)1.98607647
84Decreased central vision (HP:0007663)1.95026753
85Abnormality of chloride homeostasis (HP:0011422)1.94155570
86Peripheral hypomyelination (HP:0007182)1.92803813
87Double outlet right ventricle (HP:0001719)1.91590886
88Congenital malformation of the right heart (HP:0011723)1.91590886
89Medial flaring of the eyebrow (HP:0010747)1.90163099
90Abnormality of the epiphysis of the femoral head (HP:0010574)1.88236036
91Spastic paraparesis (HP:0002313)1.86275699
92Hypoparathyroidism (HP:0000829)1.85860139
93Renal Fanconi syndrome (HP:0001994)1.84895804
94Abnormal drinking behavior (HP:0030082)1.83962043
95Polydipsia (HP:0001959)1.83962043
96Osteomalacia (HP:0002749)1.82884547
97Insulin resistance (HP:0000855)1.80467690
98Hemorrhage of the eye (HP:0011885)1.77975233
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.77547236
100Absent epiphyses (HP:0010577)1.77270317
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77270317
102Hyperthyroidism (HP:0000836)1.76780550
103Cerebellar dysplasia (HP:0007033)1.76556555
104Gingivitis (HP:0000230)1.76431229
105Transposition of the great arteries (HP:0001669)1.73494658
106Abnormal connection of the cardiac segments (HP:0011545)1.73494658
107Abnormal ventriculo-arterial connection (HP:0011563)1.73494658
108Abnormality of femoral epiphyses (HP:0006499)1.72701938
109Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72701938
110Loss of speech (HP:0002371)1.72165114
111Spastic tetraparesis (HP:0001285)1.72150603
112Photophobia (HP:0000613)1.71139836
113Easy fatigability (HP:0003388)1.68999400
114Abnormal number of erythroid precursors (HP:0012131)1.63917379
115Heterotopia (HP:0002282)1.62786041
116Postaxial foot polydactyly (HP:0001830)1.62771029
117Decreased electroretinogram (ERG) amplitude (HP:0000654)1.60437014
118Abnormality of renal excretion (HP:0011036)1.58120131
119Bile duct proliferation (HP:0001408)1.56137886
120Abnormal biliary tract physiology (HP:0012439)1.56137886
121Rhabdomyolysis (HP:0003201)1.55906674
122Myoglobinuria (HP:0002913)1.55206872
123Constricted visual fields (HP:0001133)1.54249912
124Chronic sinusitis (HP:0011109)1.54120981
125Congenital hepatic fibrosis (HP:0002612)1.53482464
126Cleft eyelid (HP:0000625)1.53186875
127Stage 5 chronic kidney disease (HP:0003774)1.52414919
128Renal dysplasia (HP:0000110)1.49509049
129Broad distal phalanx of finger (HP:0009836)1.49017995
130Oculomotor apraxia (HP:0000657)1.47426218
131Type 2 muscle fiber atrophy (HP:0003554)1.46684325
132Abnormality of cells of the erythroid lineage (HP:0012130)1.46630524
133Short femoral neck (HP:0100864)1.43678766
134Deformed sella turcica (HP:0002681)1.41559598
135Abnormality of the renal cortex (HP:0011035)1.40682479
136Short ribs (HP:0000773)1.40440848
137Abnormal urine output (HP:0012590)1.39301253
138Abnormality of the neuromuscular junction (HP:0003398)1.38878557
139Fatigable weakness (HP:0003473)1.38878557
140Cystic liver disease (HP:0006706)1.37217575
141Facial cleft (HP:0002006)1.34591524
142Muscle fiber atrophy (HP:0100295)1.33635188
143Personality changes (HP:0000751)1.32998720
144Hypercholesterolemia (HP:0003124)1.32174809
145Type II lissencephaly (HP:0007260)1.28706167
146Aplasia/Hypoplasia of the lens (HP:0008063)1.26648175
147Generalized muscle weakness (HP:0003324)1.26274499
148Truncal obesity (HP:0001956)1.25205839
149Bell-shaped thorax (HP:0001591)1.24281202
150Asymmetric septal hypertrophy (HP:0001670)1.23946526
151Bulbar palsy (HP:0001283)1.23927591
152Neurofibrillary tangles (HP:0002185)1.22570636
153Global brain atrophy (HP:0002283)1.22055748
154Retrobulbar optic neuritis (HP:0100654)1.21676920
155Optic neuritis (HP:0100653)1.21676920
156Myositis (HP:0100614)1.19556525
157Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.19406611
158Retinal atrophy (HP:0001105)1.18519296
159Aplasia/Hypoplasia affecting the retina (HP:0008061)1.18344897
160Polymicrogyria (HP:0002126)1.17071492
161Polyuria (HP:0000103)1.16382964
162Lissencephaly (HP:0001339)1.16084410
163Orchitis (HP:0100796)1.15549784
164Bundle branch block (HP:0011710)1.14419276
165Sloping forehead (HP:0000340)1.12939280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK18.47052176
2PDK46.17716563
3PDK36.17716563
4PRKD35.45137893
5ICK4.94317544
6PDK24.56117467
7DDR24.12726129
8BRD43.13558057
9MAP4K22.88042186
10INSRR2.84966319
11CAMK1G2.73335097
12PLK22.66696424
13STK38L2.44112640
14NEK22.16411058
15STK382.02526757
16PTK2B1.98349926
17DYRK1B1.86150161
18MST1R1.70236144
19CDK121.63969580
20WNK41.57875763
21TESK21.53530759
22PIK3CG1.50216977
23DYRK31.48324130
24CAMK1D1.45697793
25EEF2K1.44155729
26CDK71.34841668
27PASK1.32398263
28PDK11.29736600
29MAP3K101.21610415
30STK391.21549830
31KSR21.15938213
32MAP3K111.11622413
33LATS21.02429199
34MAP2K21.00837058
35SIK21.00741659
36MAPK150.98521919
37MAP4K10.98194750
38BUB10.97011982
39PNCK0.93300312
40PDPK10.89986198
41MAP3K90.88197100
42CCNB10.81456326
43STK160.78282682
44IRAK10.76954269
45CHEK20.75188427
46BRAF0.74425192
47RIPK40.73691610
48CDC70.68413112
49KIT0.68151677
50LATS10.67928933
51RPS6KA20.67126699
52TTK0.66802841
53PRKAA20.64238381
54CAMK10.61612490
55WEE10.60842405
56PAK40.59665609
57AKT30.58171923
58ZAP700.57558965
59CSF1R0.55442377
60UHMK10.53830789
61MAP3K20.53248096
62MAP3K10.51876626
63PRKG10.51335652
64RPS6KA40.50671232
65PAK10.50578475
66ATR0.50014512
67PAK20.48768618
68TYRO30.46508112
69GSK3B0.45524093
70ARAF0.45293397
71RPS6KC10.44572620
72RPS6KL10.44572620
73PIM20.44013190
74BRSK20.43872605
75IRAK20.43334557
76PIM10.41561899
77CHEK10.41496012
78TAF10.41095563
79MAPK10.40844270
80MAPK110.40185639
81CDK10.39751670
82PINK10.38523209
83RPS6KA60.38493869
84ROCK10.38425018
85SGK2230.38219788
86SGK4940.38219788
87CHUK0.38203434
88STK100.37529145
89STK30.36927127
90MAPK80.36794930
91MAP2K60.36643677
92TXK0.35816829
93TYK20.34241806
94CDK30.33540727
95BRSK10.32491206
96IKBKB0.31763597
97CAMK40.31567619
98TLK10.31183094
99MTOR0.30546345
100MUSK0.30386743
101CAMKK10.30188256
102JAK30.29994200
103PLK10.29179065
104TRIB30.28912860
105CDK40.28665418
106ATM0.28541025
107MARK20.28539667
108WNK10.28338334
109TBK10.26416470
110SGK10.25150776
111BTK0.24317280
112VRK10.24164348
113KDR0.23396389
114MAPK140.23311784
115AURKA0.23033566
116PLK40.22658920
117EIF2AK10.22086915
118ERN10.21678788
119NTRK20.20094790
120PRKCG0.19784035
121FLT30.19458013
122CSNK2A10.19400933
123SMG10.17458517
124PRKCB0.17384133
125MAPK100.16985080
126EIF2AK30.16869253
127AKT10.16546610
128NEK60.16329580
129MAP3K70.14937979
130RPS6KA10.14865804
131CDK60.14700588
132RPS6KB10.14536835
133SCYL20.14247101
134FGFR40.13596168
135BLK0.13424894
136MAPKAPK50.13170122
137AURKB0.12318499
138LMTK20.12203260
139CDK20.11276801
140PRKCZ0.11125545
141STK40.10518213
142SYK0.09956042
143CSNK2A20.09940862
144GRK60.09714018
145MAP3K130.08858829
146PRKCQ0.08323315
147NEK90.07747703
148LCK0.07634507
149PRKCD0.07535366
150RPS6KA50.07440326
151MAP3K80.07227104
152PRKAA10.06129186
153MAPK90.05631309
154TNK20.05529227
155PRKG20.05500912
156MAPK40.05275960
157CDK150.04858344
158BMPR1B0.02282398

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.49400649
2Fatty acid biosynthesis_Homo sapiens_hsa000614.25361335
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.90665643
4Olfactory transduction_Homo sapiens_hsa047403.22460383
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.96114090
6DNA replication_Homo sapiens_hsa030302.92191286
7Linoleic acid metabolism_Homo sapiens_hsa005912.87810674
8Vitamin B6 metabolism_Homo sapiens_hsa007502.74656308
9Pyruvate metabolism_Homo sapiens_hsa006202.54237517
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54129812
11Basal transcription factors_Homo sapiens_hsa030222.42449542
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.39052182
13Selenocompound metabolism_Homo sapiens_hsa004502.29102377
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.29062201
15Butanoate metabolism_Homo sapiens_hsa006502.28136390
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26345933
17Glucagon signaling pathway_Homo sapiens_hsa049222.05320690
18Systemic lupus erythematosus_Homo sapiens_hsa053222.02204466
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.92448997
20Graft-versus-host disease_Homo sapiens_hsa053321.88914652
21Fanconi anemia pathway_Homo sapiens_hsa034601.88910314
22Allograft rejection_Homo sapiens_hsa053301.80021353
23Antigen processing and presentation_Homo sapiens_hsa046121.76264841
24Type I diabetes mellitus_Homo sapiens_hsa049401.75744640
25Autoimmune thyroid disease_Homo sapiens_hsa053201.75025079
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.66542289
27RNA transport_Homo sapiens_hsa030131.66047216
28Pentose phosphate pathway_Homo sapiens_hsa000301.65355495
29Fructose and mannose metabolism_Homo sapiens_hsa000511.61051861
30Glycerolipid metabolism_Homo sapiens_hsa005611.58065000
31Pyrimidine metabolism_Homo sapiens_hsa002401.57567062
32Propanoate metabolism_Homo sapiens_hsa006401.54698123
33Type II diabetes mellitus_Homo sapiens_hsa049301.52704279
34Phenylalanine metabolism_Homo sapiens_hsa003601.50365558
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49933084
36Purine metabolism_Homo sapiens_hsa002301.44218611
37Oocyte meiosis_Homo sapiens_hsa041141.43981104
38Glutathione metabolism_Homo sapiens_hsa004801.43337067
39Fat digestion and absorption_Homo sapiens_hsa049751.42631844
40Base excision repair_Homo sapiens_hsa034101.40406256
41Taste transduction_Homo sapiens_hsa047421.38090347
42Viral myocarditis_Homo sapiens_hsa054161.35398923
43Ether lipid metabolism_Homo sapiens_hsa005651.35389495
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.33733192
45PPAR signaling pathway_Homo sapiens_hsa033201.31186270
46mRNA surveillance pathway_Homo sapiens_hsa030151.28011401
47Mismatch repair_Homo sapiens_hsa034301.25279637
48Carbon metabolism_Homo sapiens_hsa012001.22255063
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.15982392
50Spliceosome_Homo sapiens_hsa030401.14489652
51Alcoholism_Homo sapiens_hsa050341.06838653
52Legionellosis_Homo sapiens_hsa051341.05587997
53Acute myeloid leukemia_Homo sapiens_hsa052211.04534757
54Inositol phosphate metabolism_Homo sapiens_hsa005621.03398730
55Fatty acid degradation_Homo sapiens_hsa000711.03140163
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00669605
57Arginine and proline metabolism_Homo sapiens_hsa003300.99483058
58Cardiac muscle contraction_Homo sapiens_hsa042600.99064352
59Amphetamine addiction_Homo sapiens_hsa050310.98813151
60Phototransduction_Homo sapiens_hsa047440.97148458
61Homologous recombination_Homo sapiens_hsa034400.95998286
62Fatty acid metabolism_Homo sapiens_hsa012120.95366235
63Proteasome_Homo sapiens_hsa030500.94867451
64Arachidonic acid metabolism_Homo sapiens_hsa005900.89283256
65Other glycan degradation_Homo sapiens_hsa005110.87521480
66Mineral absorption_Homo sapiens_hsa049780.86667121
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.82195008
68Nucleotide excision repair_Homo sapiens_hsa034200.80936516
69Biosynthesis of amino acids_Homo sapiens_hsa012300.80692777
70Cell cycle_Homo sapiens_hsa041100.80187885
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78423245
72Viral carcinogenesis_Homo sapiens_hsa052030.77375720
73Synaptic vesicle cycle_Homo sapiens_hsa047210.76720897
74Calcium signaling pathway_Homo sapiens_hsa040200.76095472
75Huntingtons disease_Homo sapiens_hsa050160.75745986
76Renin-angiotensin system_Homo sapiens_hsa046140.75174807
77N-Glycan biosynthesis_Homo sapiens_hsa005100.74141926
78Hedgehog signaling pathway_Homo sapiens_hsa043400.70158714
79Protein digestion and absorption_Homo sapiens_hsa049740.68813637
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66001871
81cAMP signaling pathway_Homo sapiens_hsa040240.65572003
82Salivary secretion_Homo sapiens_hsa049700.64875093
83B cell receptor signaling pathway_Homo sapiens_hsa046620.64801172
84Arginine biosynthesis_Homo sapiens_hsa002200.64584502
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63143763
86RNA degradation_Homo sapiens_hsa030180.62604467
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62516427
88Morphine addiction_Homo sapiens_hsa050320.61777007
89Sulfur relay system_Homo sapiens_hsa041220.60449951
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.60289446
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60091600
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59876836
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58379481
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56584137
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56514742
96Chemical carcinogenesis_Homo sapiens_hsa052040.55015328
97Measles_Homo sapiens_hsa051620.54972295
98ABC transporters_Homo sapiens_hsa020100.54524297
99Tyrosine metabolism_Homo sapiens_hsa003500.52778693
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51018395
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49289198
102Thyroid hormone synthesis_Homo sapiens_hsa049180.49116657
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.49061696
104Dorso-ventral axis formation_Homo sapiens_hsa043200.48298155
105MAPK signaling pathway_Homo sapiens_hsa040100.46374079
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.46276875
107Epstein-Barr virus infection_Homo sapiens_hsa051690.45031238
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43144288
109Herpes simplex infection_Homo sapiens_hsa051680.42321396
110Circadian entrainment_Homo sapiens_hsa047130.42216542
111Non-homologous end-joining_Homo sapiens_hsa034500.42202560
112Renin secretion_Homo sapiens_hsa049240.38819543
113Metabolic pathways_Homo sapiens_hsa011000.38396466
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37722511
115Estrogen signaling pathway_Homo sapiens_hsa049150.37076034
116VEGF signaling pathway_Homo sapiens_hsa043700.35058536
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34178299
118Shigellosis_Homo sapiens_hsa051310.33927072
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33768919
120Prolactin signaling pathway_Homo sapiens_hsa049170.33600647
121Insulin secretion_Homo sapiens_hsa049110.33288952
122Endocytosis_Homo sapiens_hsa041440.33181852
123Primary immunodeficiency_Homo sapiens_hsa053400.32349945
124AMPK signaling pathway_Homo sapiens_hsa041520.31692013
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31360748
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30794136
127Collecting duct acid secretion_Homo sapiens_hsa049660.27898953
128HIF-1 signaling pathway_Homo sapiens_hsa040660.27723846
129Tight junction_Homo sapiens_hsa045300.26936414
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26935923
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26625884
132Toxoplasmosis_Homo sapiens_hsa051450.25880453
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25162655
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25020194
135Gastric acid secretion_Homo sapiens_hsa049710.24965763
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24931039
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24825497
138Retinol metabolism_Homo sapiens_hsa008300.23818389
139Nicotine addiction_Homo sapiens_hsa050330.23338608
140Bile secretion_Homo sapiens_hsa049760.22651902
141Influenza A_Homo sapiens_hsa051640.22200062
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.20668954
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.20456311
144T cell receptor signaling pathway_Homo sapiens_hsa046600.20341539
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20176613
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20127308
147Glutamatergic synapse_Homo sapiens_hsa047240.20094035
148mTOR signaling pathway_Homo sapiens_hsa041500.19666555
149Pancreatic secretion_Homo sapiens_hsa049720.19003506
150Chemokine signaling pathway_Homo sapiens_hsa040620.18854756
151Cholinergic synapse_Homo sapiens_hsa047250.18212444
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18206436

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »