TST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.87227947
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.87227947
3L-phenylalanine metabolic process (GO:0006558)6.61351864
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.61351864
5epoxygenase P450 pathway (GO:0019373)6.27179387
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.13042632
7aromatic amino acid family catabolic process (GO:0009074)6.12696267
8glyoxylate metabolic process (GO:0046487)5.67229503
9high-density lipoprotein particle remodeling (GO:0034375)5.60179015
10bile acid biosynthetic process (GO:0006699)5.54700465
11tryptophan catabolic process (GO:0006569)5.52797101
12indole-containing compound catabolic process (GO:0042436)5.52797101
13indolalkylamine catabolic process (GO:0046218)5.52797101
14alpha-linolenic acid metabolic process (GO:0036109)5.46253560
15* sulfur amino acid catabolic process (GO:0000098)5.43135797
16kynurenine metabolic process (GO:0070189)5.38331022
17cysteine metabolic process (GO:0006534)5.29984092
18exogenous drug catabolic process (GO:0042738)5.22168507
19tryptophan metabolic process (GO:0006568)5.19640067
20reverse cholesterol transport (GO:0043691)5.08134968
21urea cycle (GO:0000050)5.07862741
22urea metabolic process (GO:0019627)5.07862741
23negative regulation of fibrinolysis (GO:0051918)5.02675915
24response to nitrosative stress (GO:0051409)4.97753421
25drug metabolic process (GO:0017144)4.96198290
26cellular glucuronidation (GO:0052695)4.94290083
27regulation of cholesterol esterification (GO:0010872)4.87487856
28ethanol oxidation (GO:0006069)4.84664746
29serine family amino acid catabolic process (GO:0009071)4.84231349
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84136659
31regulation of fibrinolysis (GO:0051917)4.83401029
32peptidyl-glutamic acid carboxylation (GO:0017187)4.82107651
33protein carboxylation (GO:0018214)4.82107651
34plasma lipoprotein particle remodeling (GO:0034369)4.77324468
35protein-lipid complex remodeling (GO:0034368)4.77324468
36macromolecular complex remodeling (GO:0034367)4.77324468
37regulation of protein activation cascade (GO:2000257)4.73818807
38bile acid metabolic process (GO:0008206)4.68720630
39nitrogen cycle metabolic process (GO:0071941)4.67788686
40blood coagulation, intrinsic pathway (GO:0007597)4.67399296
41glucuronate metabolic process (GO:0019585)4.66345373
42uronic acid metabolic process (GO:0006063)4.66345373
43complement activation, alternative pathway (GO:0006957)4.64060261
44xenobiotic catabolic process (GO:0042178)4.59988711
45amino-acid betaine metabolic process (GO:0006577)4.59976430
46regulation of triglyceride catabolic process (GO:0010896)4.58758578
47omega-hydroxylase P450 pathway (GO:0097267)4.56035742
48phenylpropanoid metabolic process (GO:0009698)4.52616833
49homocysteine metabolic process (GO:0050667)4.51615773
50benzene-containing compound metabolic process (GO:0042537)4.51092041
51phospholipid efflux (GO:0033700)4.47509880
52aromatic amino acid family metabolic process (GO:0009072)4.43402872
53regulation of complement activation (GO:0030449)4.41859746
54alpha-amino acid catabolic process (GO:1901606)4.39961731
55lysine metabolic process (GO:0006553)4.39886269
56lysine catabolic process (GO:0006554)4.39886269
57NADH metabolic process (GO:0006734)4.35415684
58negative regulation of cholesterol transport (GO:0032375)4.34403100
59negative regulation of sterol transport (GO:0032372)4.34403100
60tyrosine metabolic process (GO:0006570)4.25457408
61cellular modified amino acid catabolic process (GO:0042219)4.24438637
62acylglycerol homeostasis (GO:0055090)4.19871796
63triglyceride homeostasis (GO:0070328)4.19871796
64low-density lipoprotein particle remodeling (GO:0034374)4.19424517
65* cellular amino acid catabolic process (GO:0009063)4.13495051
66cholesterol efflux (GO:0033344)4.09807019
67glycine metabolic process (GO:0006544)4.08778317
68negative regulation of hemostasis (GO:1900047)4.08693679
69negative regulation of blood coagulation (GO:0030195)4.08693679
70serine family amino acid metabolic process (GO:0009069)4.08462473
71plasma lipoprotein particle clearance (GO:0034381)4.08394522
72hormone catabolic process (GO:0042447)4.07597239
73serine family amino acid biosynthetic process (GO:0009070)4.06662301
74glutamate metabolic process (GO:0006536)4.06127367
75coenzyme catabolic process (GO:0009109)4.04824971
76proline metabolic process (GO:0006560)4.03238510
77cellular ketone body metabolic process (GO:0046950)4.02818062
78aldehyde catabolic process (GO:0046185)4.01387035
79regulation of cholesterol biosynthetic process (GO:0045540)3.99062840
80plasma lipoprotein particle assembly (GO:0034377)3.98855592
81cellular biogenic amine catabolic process (GO:0042402)3.98619235
82amine catabolic process (GO:0009310)3.98619235
83imidazole-containing compound metabolic process (GO:0052803)3.98047608
84bile acid and bile salt transport (GO:0015721)3.92164795
85indolalkylamine metabolic process (GO:0006586)3.87889877
86alkaloid metabolic process (GO:0009820)3.85922490
87protein activation cascade (GO:0072376)3.80828103
88negative regulation of coagulation (GO:0050819)3.78916076
89fat-soluble vitamin biosynthetic process (GO:0042362)3.78272121
90regulation of cholesterol metabolic process (GO:0090181)3.76810494
91negative regulation of lipase activity (GO:0060192)3.76354047
92regulation of cholesterol homeostasis (GO:2000188)3.74418423
93regulation of plasminogen activation (GO:0010755)3.72872656
94plasma lipoprotein particle organization (GO:0071827)3.72769119
95regulation of bile acid biosynthetic process (GO:0070857)3.72395838
96short-chain fatty acid metabolic process (GO:0046459)3.72090985
97very-low-density lipoprotein particle assembly (GO:0034379)3.71637886
98* carboxylic acid catabolic process (GO:0046395)3.69853521
99* organic acid catabolic process (GO:0016054)3.69853521
100flavonoid metabolic process (GO:0009812)3.68785811
101dicarboxylic acid biosynthetic process (GO:0043650)3.68617384
102phospholipid homeostasis (GO:0055091)3.68169196
103complement activation, classical pathway (GO:0006958)3.67289647
104drug catabolic process (GO:0042737)3.65995163
105arginine metabolic process (GO:0006525)3.63593660
106ethanol metabolic process (GO:0006067)3.63460257
107oxidative demethylation (GO:0070989)3.61537362
108negative regulation of wound healing (GO:0061045)3.61420785
109carnitine metabolic process (GO:0009437)3.60267555
110complement activation (GO:0006956)3.58424624
111cholesterol homeostasis (GO:0042632)3.55871162
112positive regulation of lipoprotein lipase activity (GO:0051006)3.55787623
113positive regulation of triglyceride lipase activity (GO:0061365)3.55787623
114acute-phase response (GO:0006953)3.55478963
115fibrinolysis (GO:0042730)3.54665956
116protein-lipid complex assembly (GO:0065005)3.53932847
117fatty acid oxidation (GO:0019395)3.52811510
118positive regulation of lipid catabolic process (GO:0050996)3.52546931
119monocarboxylic acid catabolic process (GO:0072329)3.51124620
120sterol homeostasis (GO:0055092)3.49350303
121lipid oxidation (GO:0034440)3.48581481
122intestinal absorption (GO:0050892)3.47571270
123primary alcohol catabolic process (GO:0034310)3.46375603
124drug transmembrane transport (GO:0006855)3.44727067
125daunorubicin metabolic process (GO:0044597)3.40968427
126polyketide metabolic process (GO:0030638)3.40968427
127doxorubicin metabolic process (GO:0044598)3.40968427
128glutamine family amino acid biosynthetic process (GO:0009084)3.39618523
129regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.37742812
130positive regulation of fatty acid biosynthetic process (GO:0045723)3.36767104
131drug transport (GO:0015893)3.23746220
132fructose metabolic process (GO:0006000)3.17901066
133oxaloacetate metabolic process (GO:0006107)3.17894380
134positive regulation of hemostasis (GO:1900048)3.17025627
135positive regulation of blood coagulation (GO:0030194)3.17025627
136arginine catabolic process (GO:0006527)3.08793319
137primary alcohol metabolic process (GO:0034308)3.01324182
138aminoglycoside antibiotic metabolic process (GO:0030647)2.99167951
139positive regulation of triglyceride metabolic process (GO:0090208)2.97708028
140positive regulation of coagulation (GO:0050820)2.97165966
141xenobiotic metabolic process (GO:0006805)2.96454378
142protein-lipid complex subunit organization (GO:0071825)2.96136965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.90249136
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.86794298
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.43860883
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.17975970
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.30970030
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.13421929
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66350538
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.77270549
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65064265
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06741878
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00121550
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4093954
13* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99195301
14CLOCK_20551151_ChIP-Seq_293T_Human1.98970740
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93939629
16SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83857926
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67293021
18TET1_21451524_ChIP-Seq_MESCs_Mouse1.64983363
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60978360
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.58514087
21VDR_21846776_ChIP-Seq_THP-1_Human1.50885485
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.50765046
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48578833
24SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42862062
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42514017
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31833447
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31446728
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30609529
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.29961083
30GATA1_22025678_ChIP-Seq_K562_Human1.25828847
31BCL6_27268052_Chip-Seq_Bcells_Human1.24759813
32BCOR_27268052_Chip-Seq_Bcells_Human1.24601604
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23775023
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23366828
35HTT_18923047_ChIP-ChIP_STHdh_Human1.21926085
36GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21009272
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.20942237
38P68_20966046_ChIP-Seq_HELA_Human1.20903797
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20319230
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19859530
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17319320
42SA1_27219007_Chip-Seq_Bcells_Human1.16170439
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14477782
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14001826
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11592548
46CTCF_27219007_Chip-Seq_Bcells_Human1.10536956
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10059300
48GATA4_25053715_ChIP-Seq_YYC3_Human1.09553546
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08067392
50ZNF263_19887448_ChIP-Seq_K562_Human1.06947653
51JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01518474
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01185531
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.00944415
54SMC4_20622854_ChIP-Seq_HELA_Human1.00210005
55DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98027518
56E2F1_20622854_ChIP-Seq_HELA_Human0.97510413
57CREB1_26743006_Chip-Seq_LNCaP_Human0.96517179
58CTCF_21964334_Chip-Seq_Bcells_Human0.95819342
59* ELF1_20517297_ChIP-Seq_JURKAT_Human0.95768216
60* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95498528
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95482406
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95025803
63* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93461555
64SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91235646
65PHF8_20622854_ChIP-Seq_HELA_Human0.91134036
66BP1_19119308_ChIP-ChIP_Hs578T_Human0.90798604
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90666402
68CTCF_20526341_ChIP-Seq_ESCs_Human0.90621614
69* YY1_22570637_ChIP-Seq_MALME-3M_Human0.89168223
70CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88493230
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88421197
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88115743
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88094768
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87052817
75VDR_24763502_ChIP-Seq_THP-1_Human0.86392239
76KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86138784
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86009737
78ATF3_27146783_Chip-Seq_COLON_Human0.85392945
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85330656
80ESR1_20079471_ChIP-ChIP_T-47D_Human0.85089971
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84256597
82TP63_22573176_ChIP-Seq_HFKS_Human0.83175814
83CDX2_20551321_ChIP-Seq_CACO-2_Human0.82952952
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81967804
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.79938229
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79744908
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77792660
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77792660
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77587182
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77548868
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77307796
92TRIM28_21343339_ChIP-Seq_HEK293_Human0.77026860
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75946303
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75003761
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74488611
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73195656
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72536482
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70693523
99* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69962452
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.69168573
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67423886
102GATA6_25053715_ChIP-Seq_YYC3_Human0.66097674
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65926293
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.65092065
105SOX2_20726797_ChIP-Seq_SW620_Human0.64838369
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64602248
107LXR_22292898_ChIP-Seq_THP-1_Human0.64042093
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.63884984
109FOXO3_23340844_ChIP-Seq_DLD1_Human0.63368678
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60378957
111RACK7_27058665_Chip-Seq_MCF-7_Human0.60305239
112GATA3_24758297_ChIP-Seq_MCF-7_Human0.59917416
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.58024233
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57607655
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57569811
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57537888
117AR_20517297_ChIP-Seq_VCAP_Human0.54656204
118CEBPB_22108803_ChIP-Seq_LS180_Human0.53077260
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52844205
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.51412446
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.50640593
122TP63_17297297_ChIP-ChIP_HaCaT_Human0.50622949
123ERG_20517297_ChIP-Seq_VCAP_Human0.50166777
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.49911698
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47364703
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47296858
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.46991089
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45919406
129GATA2_19941826_ChIP-Seq_K562_Human0.45426700
130GATA1_19941826_ChIP-Seq_K562_Human0.45188505
131MYC_19915707_ChIP-ChIP_AK7_Human0.44780470
132ESET_19884257_ChIP-Seq_ESCs_Mouse0.43903414
133EGR1_19032775_ChIP-ChIP_M12_Human0.43053271
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.42767222
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.42637311
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.42474298
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.41936410
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.41418622
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40639646
140MYC_27129775_Chip-Seq_CORNEA_Mouse0.40481721
141CSB_26484114_Chip-Seq_FIBROBLAST_Human0.40396030
142* GATA1_19941827_ChIP-Seq_MEL_Mouse0.39703523
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.39353117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81857824
2MP0005360_urolithiasis6.77068991
3MP0005365_abnormal_bile_salt6.04459136
4MP0005085_abnormal_gallbladder_physiolo6.03090870
5MP0008875_abnormal_xenobiotic_pharmacok5.76439969
6MP0003806_abnormal_nucleotide_metabolis4.11680841
7MP0010329_abnormal_lipoprotein_level3.61512252
8MP0003252_abnormal_bile_duct3.49165731
9MP0009840_abnormal_foam_cell3.28392131
10MP0005083_abnormal_biliary_tract2.92766691
11MP0005332_abnormal_amino_acid2.85231709
12MP0001666_abnormal_nutrient_absorption2.63910686
13MP0003195_calcinosis2.47512172
14MP0003191_abnormal_cellular_cholesterol2.35380407
15MP0004019_abnormal_vitamin_homeostasis2.31325691
16MP0002118_abnormal_lipid_homeostasis2.05901910
17MP0000609_abnormal_liver_physiology2.04328815
18MP0003186_abnormal_redox_activity1.97870812
19MP0005319_abnormal_enzyme/_coenzyme1.85801578
20MP0005058_abnormal_lysosome_morphology1.76173154
21MP0002254_reproductive_system_inflammat1.71906742
22MP0002138_abnormal_hepatobiliary_system1.70404159
23MP0003868_abnormal_feces_composition1.66427342
24MP0005584_abnormal_enzyme/coenzyme_acti1.55623198
25MP0001764_abnormal_homeostasis1.54416513
26MP0005647_abnormal_sex_gland1.46552664
27MP0003011_delayed_dark_adaptation1.39591916
28MP0009643_abnormal_urine_homeostasis1.39058740
29MP0009697_abnormal_copulation1.35491599
30MP0003656_abnormal_erythrocyte_physiolo1.31883187
31MP0005451_abnormal_body_composition1.19916047
32MP0003705_abnormal_hypodermis_morpholog1.17992776
33MP0003879_abnormal_hair_cell1.11420183
34MP0009764_decreased_sensitivity_to1.10730900
35MP0000598_abnormal_liver_morphology1.07714917
36MP0010155_abnormal_intestine_physiology1.07367815
37MP0005636_abnormal_mineral_homeostasis1.03429946
38MP0000678_abnormal_parathyroid_gland1.03428998
39MP0009379_abnormal_foot_pigmentation1.01584839
40MP0000604_amyloidosis1.00089177
41MP0005408_hypopigmentation0.98959766
42MP0010368_abnormal_lymphatic_system0.98568720
43MP0008004_abnormal_stomach_pH0.96223648
44MP0002249_abnormal_larynx_morphology0.92293350
45MP0009763_increased_sensitivity_to0.92017658
46MP0002132_abnormal_respiratory_system0.90736734
47MP0003690_abnormal_glial_cell0.90086614
48MP0009053_abnormal_anal_canal0.89172784
49MP0005670_abnormal_white_adipose0.87473899
50MP0003183_abnormal_peptide_metabolism0.84217805
51MP0005376_homeostasis/metabolism_phenot0.83080332
52MP0001663_abnormal_digestive_system0.81603300
53MP0009642_abnormal_blood_homeostasis0.81526555
54MP0003866_abnormal_defecation0.80963257
55MP0005501_abnormal_skin_physiology0.78974277
56MP0009765_abnormal_xenobiotic_induced0.78880135
57MP0004185_abnormal_adipocyte_glucose0.78610722
58MP0008469_abnormal_protein_level0.78426320
59MP0001756_abnormal_urination0.76368804
60MP0001664_abnormal_digestion0.75279532
61MP0000249_abnormal_blood_vessel0.74469871
62MP0002876_abnormal_thyroid_physiology0.72760544
63MP0005084_abnormal_gallbladder_morpholo0.71364852
64MP0000490_abnormal_crypts_of0.71133564
65MP0005266_abnormal_metabolism0.70947555
66MP0006036_abnormal_mitochondrial_physio0.70929854
67MP0005381_digestive/alimentary_phenotyp0.70333586
68MP0000477_abnormal_intestine_morphology0.70025943
69MP0003329_amyloid_beta_deposits0.69655854
70MP0005220_abnormal_exocrine_pancreas0.69519197
71MP0004147_increased_porphyrin_level0.69137606
72MP0004782_abnormal_surfactant_physiolog0.67742481
73MP0005334_abnormal_fat_pad0.66340762
74MP0002971_abnormal_brown_adipose0.66264439
75MP0002078_abnormal_glucose_homeostasis0.66204478
76MP0002089_abnormal_postnatal_growth/wei0.65562267
77MP0004043_abnormal_pH_regulation0.64994652
78MP0005375_adipose_tissue_phenotype0.64866797
79MP0004272_abnormal_basement_membrane0.64698111
80MP0004858_abnormal_nervous_system0.63081890
81MP0000467_abnormal_esophagus_morphology0.63066127
82MP0003075_altered_response_to0.62062937
83MP0004264_abnormal_extraembryonic_tissu0.61970222
84MP0004130_abnormal_muscle_cell0.61542078
85MP0008789_abnormal_olfactory_epithelium0.59893448
86MP0008260_abnormal_autophagy0.59465968
87MP0010352_gastrointestinal_tract_polyps0.59434152
88MP0000639_abnormal_adrenal_gland0.58860454
89MP0002136_abnormal_kidney_physiology0.58473495
90MP0000858_altered_metastatic_potential0.58172753
91MP0005023_abnormal_wound_healing0.57746518
92MP0009333_abnormal_splenocyte_physiolog0.57657918
93MP0005248_abnormal_Harderian_gland0.57318201
94MP0005535_abnormal_body_temperature0.56476716
95MP0008872_abnormal_physiological_respon0.56467807
96MP0001984_abnormal_olfaction0.55981831
97MP0005165_increased_susceptibility_to0.55967313
98MP0003638_abnormal_response/metabolism_0.55729321
99MP0003566_abnormal_cell_adhesion0.55672626
100MP0003436_decreased_susceptibility_to0.55205955
101MP0001845_abnormal_inflammatory_respons0.53759413
102MP0001849_ear_inflammation0.52815581
103MP0003303_peritoneal_inflammation0.52653156
104MP0009785_altered_susceptibility_to0.51594905
105MP0005394_taste/olfaction_phenotype0.50747679
106MP0005499_abnormal_olfactory_system0.50747679
107MP0000566_synostosis0.50118019
108MP0004883_abnormal_blood_vessel0.49358784
109MP0002796_impaired_skin_barrier0.47274779
110MP0010234_abnormal_vibrissa_follicle0.45955286
111MP0001853_heart_inflammation0.45330368
112MP0009384_cardiac_valve_regurgitation0.45092715
113MP0005166_decreased_susceptibility_to0.44831932
114MP0005448_abnormal_energy_balance0.44630835
115MP0005395_other_phenotype0.44161815
116MP0005666_abnormal_adipose_tissue0.42276257
117MP0003953_abnormal_hormone_level0.41763115
118MP0003724_increased_susceptibility_to0.41748275
119MP0002928_abnormal_bile_duct0.41098119
120MP0005464_abnormal_platelet_physiology0.40953112
121MP0003718_maternal_effect0.39378406
122MP0009115_abnormal_fat_cell0.39279505
123MP0001661_extended_life_span0.38635580
124MP0003453_abnormal_keratinocyte_physiol0.38580954
125MP0010030_abnormal_orbit_morphology0.38006638
126MP0005164_abnormal_response_to0.37986957
127MP0001346_abnormal_lacrimal_gland0.37388536
128MP0008873_increased_physiological_sensi0.36460000
129MP0001881_abnormal_mammary_gland0.35844259
130MP0000579_abnormal_nail_morphology0.35843010
131MP0002295_abnormal_pulmonary_circulatio0.34554527
132MP0002060_abnormal_skin_morphology0.34411827
133MP0002098_abnormal_vibrissa_morphology0.33811624
134MP0006035_abnormal_mitochondrial_morpho0.33783151
135MP0002822_catalepsy0.32913802

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01762970
2Intrahepatic cholestasis (HP:0001406)6.93127006
3Deep venous thrombosis (HP:0002625)6.86439339
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.48965170
5Xanthomatosis (HP:0000991)6.12754310
6Prolonged partial thromboplastin time (HP:0003645)6.09516461
7Hypobetalipoproteinemia (HP:0003563)5.85594385
8Hyperlipoproteinemia (HP:0010980)5.44737062
9Complement deficiency (HP:0004431)4.77139348
10Hypolipoproteinemia (HP:0010981)4.68257657
11Hyperammonemia (HP:0001987)4.64596591
12Hyperglycinuria (HP:0003108)4.56265307
13Hyperglycinemia (HP:0002154)4.48211963
14Joint hemorrhage (HP:0005261)4.44924217
15Hypoalphalipoproteinemia (HP:0003233)4.34956894
16Ketosis (HP:0001946)4.33675468
17Abnormality of serine family amino acid metabolism (HP:0010894)4.32490741
18Abnormality of glycine metabolism (HP:0010895)4.32490741
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26113263
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.19813289
21Epidermoid cyst (HP:0200040)4.18956394
22Fat malabsorption (HP:0002630)4.18189019
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16954894
24Abnormality of methionine metabolism (HP:0010901)4.14858571
25Abnormality of the common coagulation pathway (HP:0010990)4.06934551
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.01793068
27Hypoglycemic coma (HP:0001325)3.91732162
28Abnormality of fatty-acid metabolism (HP:0004359)3.83658754
29Abnormality of the intrinsic pathway (HP:0010989)3.68651050
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.60414911
31Hypercholesterolemia (HP:0003124)3.57202694
32Abnormality of pyrimidine metabolism (HP:0004353)3.54047082
33Conjugated hyperbilirubinemia (HP:0002908)3.47940660
34Abnormality of complement system (HP:0005339)3.46662847
35Purpura (HP:0000979)3.38916097
36Steatorrhea (HP:0002570)3.36477182
37Ketoacidosis (HP:0001993)3.23561124
38Hyperbilirubinemia (HP:0002904)3.22545243
39Hepatocellular carcinoma (HP:0001402)3.13412414
40Delayed CNS myelination (HP:0002188)3.13169500
41Abnormality of serum amino acid levels (HP:0003112)3.04529014
42Abnormality of nucleobase metabolism (HP:0010932)2.97970574
43Nephritis (HP:0000123)2.89359791
44Metabolic acidosis (HP:0001942)2.88718822
45Myocardial infarction (HP:0001658)2.86719756
46Gout (HP:0001997)2.80235004
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77543376
48Dicarboxylic aciduria (HP:0003215)2.77543376
49Spontaneous abortion (HP:0005268)2.72280256
50Vascular calcification (HP:0004934)2.72265342
51Lethargy (HP:0001254)2.71014682
52Abnormality of purine metabolism (HP:0004352)2.69932320
53Petechiae (HP:0000967)2.66317251
54Hypochromic microcytic anemia (HP:0004840)2.59122250
55Spastic diplegia (HP:0001264)2.57887532
56Esophageal varix (HP:0002040)2.48362036
57Amyloidosis (HP:0011034)2.44443188
58Reduced antithrombin III activity (HP:0001976)2.42724169
59Abnormality of the Achilles tendon (HP:0005109)2.42504040
60Systemic lupus erythematosus (HP:0002725)2.39690246
61Cardiovascular calcification (HP:0011915)2.38212151
62Sensorimotor neuropathy (HP:0007141)2.35376459
63Generalized aminoaciduria (HP:0002909)2.33941332
64Glycosuria (HP:0003076)2.31100991
65Abnormality of urine glucose concentration (HP:0011016)2.31100991
66Cerebral edema (HP:0002181)2.29288601
67Hypoglycemic seizures (HP:0002173)2.28413026
68Pancreatitis (HP:0001733)2.26881081
69Brushfield spots (HP:0001088)2.25237495
70Cerebral palsy (HP:0100021)2.24489557
71Irritability (HP:0000737)2.24280981
72Skin nodule (HP:0200036)2.23849052
73Ileus (HP:0002595)2.21790289
74Malnutrition (HP:0004395)2.21474903
75Abnormal gallbladder morphology (HP:0012437)2.20711226
76Neonatal onset (HP:0003623)2.20187083
77Late onset (HP:0003584)2.18574331
78Hyperphosphaturia (HP:0003109)2.18291678
79Acanthocytosis (HP:0001927)2.18139365
80Vomiting (HP:0002013)2.17926149
81Cholelithiasis (HP:0001081)2.17713363
82Hydroxyprolinuria (HP:0003080)2.14489100
83Abnormality of proline metabolism (HP:0010907)2.14489100
84Rickets (HP:0002748)2.14417405
85Abnormal cartilage morphology (HP:0002763)2.14167989
86Abdominal distention (HP:0003270)2.13494303
87Proximal tubulopathy (HP:0000114)2.12844390
88Renal cortical cysts (HP:0000803)2.12620953
89Osteomalacia (HP:0002749)2.12000505
90Mitral stenosis (HP:0001718)2.11396631
91Abnormal tarsal ossification (HP:0008369)2.10910449
92Nausea (HP:0002018)2.08847387
93Increased mean platelet volume (HP:0011877)2.08514556
94Increased serum ferritin (HP:0003281)2.07201066
95Abnormal enzyme/coenzyme activity (HP:0012379)2.06119142
96Enlarged kidneys (HP:0000105)2.04636847
97Flat acetabular roof (HP:0003180)2.04321987
98Hypophosphatemia (HP:0002148)2.04013385
99Thrombophlebitis (HP:0004418)2.01821698
100Impaired platelet aggregation (HP:0003540)2.01743641
101Abnormal platelet function (HP:0011869)2.01743641
102Abnormality of alkaline phosphatase activity (HP:0004379)2.01285739
103Elevated alkaline phosphatase (HP:0003155)2.00999129
104Opisthotonus (HP:0002179)1.99458926
105Abnormality of carpal bone ossification (HP:0006257)1.99367249
106Glomerulonephritis (HP:0000099)1.98862684
107Alkalosis (HP:0001948)1.98370411
108Abnormal gallbladder physiology (HP:0012438)1.97870213
109Cholecystitis (HP:0001082)1.97870213
110Epistaxis (HP:0000421)1.97150328
111Gingival bleeding (HP:0000225)1.96843621
112Abnormal urine phosphate concentration (HP:0012599)1.96476775
113Polycythemia (HP:0001901)1.95710515
114Abnormal platelet volume (HP:0011876)1.95528943
115Hyperactive renin-angiotensin system (HP:0000841)1.93914463
116Hemorrhage of the eye (HP:0011885)1.91435413
117Back pain (HP:0003418)1.91140570
118Recurrent gram-negative bacterial infections (HP:0005420)1.90566226
119Menorrhagia (HP:0000132)1.89973325
120Hypertriglyceridemia (HP:0002155)1.89479651
121Widely patent fontanelles and sutures (HP:0004492)1.85985561
122Abnormality of transition element cation homeostasis (HP:0011030)1.85563494
123Abnormality of the gallbladder (HP:0005264)1.85275067
124Pseudobulbar signs (HP:0002200)1.85159135
125Abnormality of iron homeostasis (HP:0011031)1.84725091
126Hypophosphatemic rickets (HP:0004912)1.84183449
127Abnormality of vitamin metabolism (HP:0100508)1.83634212
128Elevated hepatic transaminases (HP:0002910)1.83605196
129Poikilocytosis (HP:0004447)1.81825468
130Increased purine levels (HP:0004368)1.80720382
131Hyperuricemia (HP:0002149)1.80720382
132Vertebral compression fractures (HP:0002953)1.75888821
133Prolonged bleeding time (HP:0003010)1.74603369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.41642294
2ERN14.55880251
3SIK14.48105279
4SMG13.46104830
5FGFR43.44506952
6TAOK32.88905109
7NME22.76798351
8INSRR2.39275464
9TRIB32.38955013
10ERBB42.20746927
11MST1R2.17213917
12MAP3K32.08444747
13PKN21.95779407
14LATS11.88402145
15TESK11.84472265
16TESK21.74520747
17PIM21.73396282
18PRPF4B1.67184668
19MAP2K31.64490197
20PINK11.60347672
21RIPK11.56996352
22MAPK151.52283117
23MAPK111.47989129
24VRK21.47232621
25PTK61.47127240
26FLT31.45031210
27MAP3K121.42129181
28DAPK21.41397875
29MAP2K41.41063378
30PIK3CG1.37641082
31STK161.33336955
32ARAF1.32808661
33FRK1.30051639
34PRKG21.28566114
35LMTK21.26044345
36TAOK21.24892749
37STK38L1.24863936
38TYK21.23550161
39EPHB11.22858244
40SGK31.22017104
41GRK61.17020587
42SGK21.13594120
43MAP2K21.12686208
44ACVR1B1.10146087
45ERBB21.04841790
46ILK1.04764904
47NEK91.04524983
48CDK61.04406194
49MAP3K21.03007691
50RIPK41.01985838
51ABL21.01810471
52MAP3K111.00864422
53PAK41.00554991
54MAP2K61.00506888
55DAPK30.96818548
56SGK4940.95768630
57SGK2230.95768630
58JAK20.95406534
59MAP3K70.94346235
60RPS6KB20.91129714
61FGFR20.88822311
62EPHA30.88410864
63ICK0.86290191
64EPHB20.86252396
65MET0.85466462
66EPHA20.83122271
67PRKD30.82123083
68MAPK120.81916415
69BRAF0.80934477
70MAP3K100.80239368
71PRKAA20.79765868
72MAP2K10.77482305
73MAP3K140.74779307
74KDR0.74479748
75DAPK10.73863831
76PDK10.73391967
77TBK10.72423795
78MAPK40.71749753
79BLK0.71524092
80MAP4K10.68838808
81PBK0.66543620
82PRKCZ0.65830626
83ZAP700.65240127
84CAMK2G0.65056467
85GRK50.64919851
86JAK10.64295166
87CDC42BPA0.63582142
88EPHA40.63434383
89TAOK10.63081605
90LRRK20.61016918
91ADRBK20.60791091
92MAPK70.60109525
93GSK3A0.59778105
94MAPKAPK30.54152921
95MAP3K80.53230495
96PTK20.53080991
97PRKACG0.52577695
98TIE10.50827355
99DDR20.50587318
100IKBKE0.50293341
101MATK0.49422135
102PDK20.48837161
103MST40.48656295
104GRK10.47295825
105PDPK10.45991086
106DYRK1B0.45493492
107CAMK1D0.44923720
108SCYL20.42843173
109MYLK0.42704691
110AKT20.42363929
111PRKAA10.42330081
112PHKG20.41773438
113PHKG10.41773438
114PRKD20.40460833
115PRKCI0.40024840
116EEF2K0.38694200
117IRAK30.37515352
118FGFR30.36594250
119PRKCQ0.36592046
120MUSK0.36062692
121PDK40.35544893
122PDK30.35544893
123MAPKAPK20.34503468
124HIPK20.34367972
125KSR20.34247025
126IGF1R0.34097503
127FER0.33383958
128SRC0.33186345
129IRAK40.32860705
130MAP3K10.32801182
131PIK3CA0.32365976
132NLK0.32063001
133CAMK2D0.31969422
134CAMK40.30935841
135CDK70.30755378
136PAK10.30645858
137ZAK0.30379846
138CDK90.30326895
139CSK0.30284572
140TGFBR20.30065014
141MAP3K50.30015382
142IRAK20.29993100
143CSF1R0.28900422
144PRKCD0.28589015
145PRKCA0.27799479
146IKBKB0.27718965
147EIF2AK10.27714411
148AKT30.26289291
149BMX0.23982052
150MTOR0.21008097

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.07629059
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.63839391
3Nitrogen metabolism_Homo sapiens_hsa009103.58092304
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.80729328
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78137385
6Arginine biosynthesis_Homo sapiens_hsa002202.73287779
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.68753978
8Fatty acid degradation_Homo sapiens_hsa000712.58752568
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53607994
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.51506057
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46856229
12Tryptophan metabolism_Homo sapiens_hsa003802.45358828
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44386896
14Chemical carcinogenesis_Homo sapiens_hsa052042.43605368
15Complement and coagulation cascades_Homo sapiens_hsa046102.41223067
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40356116
17Butanoate metabolism_Homo sapiens_hsa006502.15952425
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.11545224
19Peroxisome_Homo sapiens_hsa041462.09898151
20Propanoate metabolism_Homo sapiens_hsa006402.01578882
21Fatty acid metabolism_Homo sapiens_hsa012121.85520857
22Histidine metabolism_Homo sapiens_hsa003401.84420545
23Caffeine metabolism_Homo sapiens_hsa002321.83554392
24PPAR signaling pathway_Homo sapiens_hsa033201.82518927
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.81071287
26Retinol metabolism_Homo sapiens_hsa008301.80228401
27beta-Alanine metabolism_Homo sapiens_hsa004101.77432576
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60735019
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55372809
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51294110
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50846765
32Phenylalanine metabolism_Homo sapiens_hsa003601.47725599
33Selenocompound metabolism_Homo sapiens_hsa004501.47519468
34Starch and sucrose metabolism_Homo sapiens_hsa005001.47406948
35Tyrosine metabolism_Homo sapiens_hsa003501.40076076
36Bile secretion_Homo sapiens_hsa049761.38636840
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38581922
38Staphylococcus aureus infection_Homo sapiens_hsa051501.34600651
39Pyruvate metabolism_Homo sapiens_hsa006201.32834308
40* Sulfur metabolism_Homo sapiens_hsa009201.31885606
41Fatty acid elongation_Homo sapiens_hsa000621.22759846
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22674655
43Steroid biosynthesis_Homo sapiens_hsa001001.22456276
44Biosynthesis of amino acids_Homo sapiens_hsa012301.19980375
45* Cysteine and methionine metabolism_Homo sapiens_hsa002701.19209740
46Folate biosynthesis_Homo sapiens_hsa007901.17944639
47Carbon metabolism_Homo sapiens_hsa012001.15605588
48Glutathione metabolism_Homo sapiens_hsa004801.14983521
49Fat digestion and absorption_Homo sapiens_hsa049751.10516449
50ABC transporters_Homo sapiens_hsa020101.07982223
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.03630903
52Arginine and proline metabolism_Homo sapiens_hsa003301.00082472
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95610134
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93647314
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93023788
56Vitamin digestion and absorption_Homo sapiens_hsa049770.83662515
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82935808
58Vitamin B6 metabolism_Homo sapiens_hsa007500.79666636
59Fatty acid biosynthesis_Homo sapiens_hsa000610.79199077
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.78289234
61Glycerolipid metabolism_Homo sapiens_hsa005610.77399353
62Other glycan degradation_Homo sapiens_hsa005110.75399806
63One carbon pool by folate_Homo sapiens_hsa006700.73222849
64Pentose phosphate pathway_Homo sapiens_hsa000300.70820948
65Lysine degradation_Homo sapiens_hsa003100.67433141
66* Sulfur relay system_Homo sapiens_hsa041220.65838571
67Galactose metabolism_Homo sapiens_hsa000520.57053380
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55000462
69* Metabolic pathways_Homo sapiens_hsa011000.48496629
70Fructose and mannose metabolism_Homo sapiens_hsa000510.46601899
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45461747
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30983499
73Prion diseases_Homo sapiens_hsa050200.27674209
74Pertussis_Homo sapiens_hsa051330.23364578
75Linoleic acid metabolism_Homo sapiens_hsa005910.23237546
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.22563201
77Insulin resistance_Homo sapiens_hsa049310.21246700
78Sphingolipid metabolism_Homo sapiens_hsa006000.17919292
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16656559
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.14680694
81Protein digestion and absorption_Homo sapiens_hsa049740.09262820
82Systemic lupus erythematosus_Homo sapiens_hsa053220.07312524
83Pancreatic secretion_Homo sapiens_hsa049720.07210893
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04477667
85Glucagon signaling pathway_Homo sapiens_hsa049220.02614760
86Vibrio cholerae infection_Homo sapiens_hsa051100.00042126
87Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2217301
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2127888
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2086529
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1875599
91Bladder cancer_Homo sapiens_hsa05219-0.1859048
92Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1526915
93African trypanosomiasis_Homo sapiens_hsa05143-0.1396804
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1354167
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1352113
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1316413
97Circadian rhythm_Homo sapiens_hsa04710-0.1310744
98Insulin signaling pathway_Homo sapiens_hsa04910-0.1305087
99Renin-angiotensin system_Homo sapiens_hsa04614-0.1183805
100Hepatitis C_Homo sapiens_hsa05160-0.1053903
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1019859
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0765104
103N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0639494
104Mineral absorption_Homo sapiens_hsa04978-0.0575306
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0562343
106AMPK signaling pathway_Homo sapiens_hsa04152-0.0407436
107Lysosome_Homo sapiens_hsa04142-0.0375543
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0338590
109Amoebiasis_Homo sapiens_hsa05146-0.0265838
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0088907

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