Rank | Gene Set | Z-score |
---|---|---|
1 | L-phenylalanine catabolic process (GO:0006559) | 6.87227947 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 6.87227947 |
3 | L-phenylalanine metabolic process (GO:0006558) | 6.61351864 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.61351864 |
5 | epoxygenase P450 pathway (GO:0019373) | 6.27179387 |
6 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.13042632 |
7 | aromatic amino acid family catabolic process (GO:0009074) | 6.12696267 |
8 | glyoxylate metabolic process (GO:0046487) | 5.67229503 |
9 | high-density lipoprotein particle remodeling (GO:0034375) | 5.60179015 |
10 | bile acid biosynthetic process (GO:0006699) | 5.54700465 |
11 | tryptophan catabolic process (GO:0006569) | 5.52797101 |
12 | indole-containing compound catabolic process (GO:0042436) | 5.52797101 |
13 | indolalkylamine catabolic process (GO:0046218) | 5.52797101 |
14 | alpha-linolenic acid metabolic process (GO:0036109) | 5.46253560 |
15 | * sulfur amino acid catabolic process (GO:0000098) | 5.43135797 |
16 | kynurenine metabolic process (GO:0070189) | 5.38331022 |
17 | cysteine metabolic process (GO:0006534) | 5.29984092 |
18 | exogenous drug catabolic process (GO:0042738) | 5.22168507 |
19 | tryptophan metabolic process (GO:0006568) | 5.19640067 |
20 | reverse cholesterol transport (GO:0043691) | 5.08134968 |
21 | urea cycle (GO:0000050) | 5.07862741 |
22 | urea metabolic process (GO:0019627) | 5.07862741 |
23 | negative regulation of fibrinolysis (GO:0051918) | 5.02675915 |
24 | response to nitrosative stress (GO:0051409) | 4.97753421 |
25 | drug metabolic process (GO:0017144) | 4.96198290 |
26 | cellular glucuronidation (GO:0052695) | 4.94290083 |
27 | regulation of cholesterol esterification (GO:0010872) | 4.87487856 |
28 | ethanol oxidation (GO:0006069) | 4.84664746 |
29 | serine family amino acid catabolic process (GO:0009071) | 4.84231349 |
30 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.84136659 |
31 | regulation of fibrinolysis (GO:0051917) | 4.83401029 |
32 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.82107651 |
33 | protein carboxylation (GO:0018214) | 4.82107651 |
34 | plasma lipoprotein particle remodeling (GO:0034369) | 4.77324468 |
35 | protein-lipid complex remodeling (GO:0034368) | 4.77324468 |
36 | macromolecular complex remodeling (GO:0034367) | 4.77324468 |
37 | regulation of protein activation cascade (GO:2000257) | 4.73818807 |
38 | bile acid metabolic process (GO:0008206) | 4.68720630 |
39 | nitrogen cycle metabolic process (GO:0071941) | 4.67788686 |
40 | blood coagulation, intrinsic pathway (GO:0007597) | 4.67399296 |
41 | glucuronate metabolic process (GO:0019585) | 4.66345373 |
42 | uronic acid metabolic process (GO:0006063) | 4.66345373 |
43 | complement activation, alternative pathway (GO:0006957) | 4.64060261 |
44 | xenobiotic catabolic process (GO:0042178) | 4.59988711 |
45 | amino-acid betaine metabolic process (GO:0006577) | 4.59976430 |
46 | regulation of triglyceride catabolic process (GO:0010896) | 4.58758578 |
47 | omega-hydroxylase P450 pathway (GO:0097267) | 4.56035742 |
48 | phenylpropanoid metabolic process (GO:0009698) | 4.52616833 |
49 | homocysteine metabolic process (GO:0050667) | 4.51615773 |
50 | benzene-containing compound metabolic process (GO:0042537) | 4.51092041 |
51 | phospholipid efflux (GO:0033700) | 4.47509880 |
52 | aromatic amino acid family metabolic process (GO:0009072) | 4.43402872 |
53 | regulation of complement activation (GO:0030449) | 4.41859746 |
54 | alpha-amino acid catabolic process (GO:1901606) | 4.39961731 |
55 | lysine metabolic process (GO:0006553) | 4.39886269 |
56 | lysine catabolic process (GO:0006554) | 4.39886269 |
57 | NADH metabolic process (GO:0006734) | 4.35415684 |
58 | negative regulation of cholesterol transport (GO:0032375) | 4.34403100 |
59 | negative regulation of sterol transport (GO:0032372) | 4.34403100 |
60 | tyrosine metabolic process (GO:0006570) | 4.25457408 |
61 | cellular modified amino acid catabolic process (GO:0042219) | 4.24438637 |
62 | acylglycerol homeostasis (GO:0055090) | 4.19871796 |
63 | triglyceride homeostasis (GO:0070328) | 4.19871796 |
64 | low-density lipoprotein particle remodeling (GO:0034374) | 4.19424517 |
65 | * cellular amino acid catabolic process (GO:0009063) | 4.13495051 |
66 | cholesterol efflux (GO:0033344) | 4.09807019 |
67 | glycine metabolic process (GO:0006544) | 4.08778317 |
68 | negative regulation of hemostasis (GO:1900047) | 4.08693679 |
69 | negative regulation of blood coagulation (GO:0030195) | 4.08693679 |
70 | serine family amino acid metabolic process (GO:0009069) | 4.08462473 |
71 | plasma lipoprotein particle clearance (GO:0034381) | 4.08394522 |
72 | hormone catabolic process (GO:0042447) | 4.07597239 |
73 | serine family amino acid biosynthetic process (GO:0009070) | 4.06662301 |
74 | glutamate metabolic process (GO:0006536) | 4.06127367 |
75 | coenzyme catabolic process (GO:0009109) | 4.04824971 |
76 | proline metabolic process (GO:0006560) | 4.03238510 |
77 | cellular ketone body metabolic process (GO:0046950) | 4.02818062 |
78 | aldehyde catabolic process (GO:0046185) | 4.01387035 |
79 | regulation of cholesterol biosynthetic process (GO:0045540) | 3.99062840 |
80 | plasma lipoprotein particle assembly (GO:0034377) | 3.98855592 |
81 | cellular biogenic amine catabolic process (GO:0042402) | 3.98619235 |
82 | amine catabolic process (GO:0009310) | 3.98619235 |
83 | imidazole-containing compound metabolic process (GO:0052803) | 3.98047608 |
84 | bile acid and bile salt transport (GO:0015721) | 3.92164795 |
85 | indolalkylamine metabolic process (GO:0006586) | 3.87889877 |
86 | alkaloid metabolic process (GO:0009820) | 3.85922490 |
87 | protein activation cascade (GO:0072376) | 3.80828103 |
88 | negative regulation of coagulation (GO:0050819) | 3.78916076 |
89 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.78272121 |
90 | regulation of cholesterol metabolic process (GO:0090181) | 3.76810494 |
91 | negative regulation of lipase activity (GO:0060192) | 3.76354047 |
92 | regulation of cholesterol homeostasis (GO:2000188) | 3.74418423 |
93 | regulation of plasminogen activation (GO:0010755) | 3.72872656 |
94 | plasma lipoprotein particle organization (GO:0071827) | 3.72769119 |
95 | regulation of bile acid biosynthetic process (GO:0070857) | 3.72395838 |
96 | short-chain fatty acid metabolic process (GO:0046459) | 3.72090985 |
97 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.71637886 |
98 | * carboxylic acid catabolic process (GO:0046395) | 3.69853521 |
99 | * organic acid catabolic process (GO:0016054) | 3.69853521 |
100 | flavonoid metabolic process (GO:0009812) | 3.68785811 |
101 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.68617384 |
102 | phospholipid homeostasis (GO:0055091) | 3.68169196 |
103 | complement activation, classical pathway (GO:0006958) | 3.67289647 |
104 | drug catabolic process (GO:0042737) | 3.65995163 |
105 | arginine metabolic process (GO:0006525) | 3.63593660 |
106 | ethanol metabolic process (GO:0006067) | 3.63460257 |
107 | oxidative demethylation (GO:0070989) | 3.61537362 |
108 | negative regulation of wound healing (GO:0061045) | 3.61420785 |
109 | carnitine metabolic process (GO:0009437) | 3.60267555 |
110 | complement activation (GO:0006956) | 3.58424624 |
111 | cholesterol homeostasis (GO:0042632) | 3.55871162 |
112 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.55787623 |
113 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.55787623 |
114 | acute-phase response (GO:0006953) | 3.55478963 |
115 | fibrinolysis (GO:0042730) | 3.54665956 |
116 | protein-lipid complex assembly (GO:0065005) | 3.53932847 |
117 | fatty acid oxidation (GO:0019395) | 3.52811510 |
118 | positive regulation of lipid catabolic process (GO:0050996) | 3.52546931 |
119 | monocarboxylic acid catabolic process (GO:0072329) | 3.51124620 |
120 | sterol homeostasis (GO:0055092) | 3.49350303 |
121 | lipid oxidation (GO:0034440) | 3.48581481 |
122 | intestinal absorption (GO:0050892) | 3.47571270 |
123 | primary alcohol catabolic process (GO:0034310) | 3.46375603 |
124 | drug transmembrane transport (GO:0006855) | 3.44727067 |
125 | daunorubicin metabolic process (GO:0044597) | 3.40968427 |
126 | polyketide metabolic process (GO:0030638) | 3.40968427 |
127 | doxorubicin metabolic process (GO:0044598) | 3.40968427 |
128 | glutamine family amino acid biosynthetic process (GO:0009084) | 3.39618523 |
129 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.37742812 |
130 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.36767104 |
131 | drug transport (GO:0015893) | 3.23746220 |
132 | fructose metabolic process (GO:0006000) | 3.17901066 |
133 | oxaloacetate metabolic process (GO:0006107) | 3.17894380 |
134 | positive regulation of hemostasis (GO:1900048) | 3.17025627 |
135 | positive regulation of blood coagulation (GO:0030194) | 3.17025627 |
136 | arginine catabolic process (GO:0006527) | 3.08793319 |
137 | primary alcohol metabolic process (GO:0034308) | 3.01324182 |
138 | aminoglycoside antibiotic metabolic process (GO:0030647) | 2.99167951 |
139 | positive regulation of triglyceride metabolic process (GO:0090208) | 2.97708028 |
140 | positive regulation of coagulation (GO:0050820) | 2.97165966 |
141 | xenobiotic metabolic process (GO:0006805) | 2.96454378 |
142 | protein-lipid complex subunit organization (GO:0071825) | 2.96136965 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.90249136 |
2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.86794298 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.43860883 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.17975970 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.30970030 |
6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.13421929 |
7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.66350538 |
8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.77270549 |
9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.65064265 |
10 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.06741878 |
11 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.00121550 |
12 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.4093954 |
13 | * TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.99195301 |
14 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.98970740 |
15 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.93939629 |
16 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.83857926 |
17 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.67293021 |
18 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.64983363 |
19 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.60978360 |
20 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.58514087 |
21 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.50885485 |
22 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.50765046 |
23 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.48578833 |
24 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.42862062 |
25 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.42514017 |
26 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.31833447 |
27 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.31446728 |
28 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.30609529 |
29 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.29961083 |
30 | GATA1_22025678_ChIP-Seq_K562_Human | 1.25828847 |
31 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.24759813 |
32 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.24601604 |
33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.23775023 |
34 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.23366828 |
35 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.21926085 |
36 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.21009272 |
37 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.20942237 |
38 | P68_20966046_ChIP-Seq_HELA_Human | 1.20903797 |
39 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.20319230 |
40 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.19859530 |
41 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.17319320 |
42 | SA1_27219007_Chip-Seq_Bcells_Human | 1.16170439 |
43 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.14477782 |
44 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.14001826 |
45 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.11592548 |
46 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.10536956 |
47 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.10059300 |
48 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.09553546 |
49 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.08067392 |
50 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.06947653 |
51 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.01518474 |
52 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.01185531 |
53 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.00944415 |
54 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.00210005 |
55 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.98027518 |
56 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.97510413 |
57 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.96517179 |
58 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.95819342 |
59 | * ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.95768216 |
60 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95498528 |
61 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.95482406 |
62 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95025803 |
63 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93461555 |
64 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.91235646 |
65 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.91134036 |
66 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.90798604 |
67 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.90666402 |
68 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.90621614 |
69 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89168223 |
70 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.88493230 |
71 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.88421197 |
72 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.88115743 |
73 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.88094768 |
74 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.87052817 |
75 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.86392239 |
76 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.86138784 |
77 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.86009737 |
78 | ATF3_27146783_Chip-Seq_COLON_Human | 0.85392945 |
79 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.85330656 |
80 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.85089971 |
81 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.84256597 |
82 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.83175814 |
83 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.82952952 |
84 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.81967804 |
85 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.79938229 |
86 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.79744908 |
87 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.77792660 |
88 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.77792660 |
89 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.77587182 |
90 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.77548868 |
91 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.77307796 |
92 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.77026860 |
93 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.75946303 |
94 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.75003761 |
95 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.74488611 |
96 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.73195656 |
97 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.72536482 |
98 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.70693523 |
99 | * SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.69962452 |
100 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.69168573 |
101 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.67423886 |
102 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.66097674 |
103 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.65926293 |
104 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.65092065 |
105 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.64838369 |
106 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.64602248 |
107 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.64042093 |
108 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.63884984 |
109 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.63368678 |
110 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.60378957 |
111 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.60305239 |
112 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.59917416 |
113 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.58024233 |
114 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.57607655 |
115 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.57569811 |
116 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.57537888 |
117 | AR_20517297_ChIP-Seq_VCAP_Human | 0.54656204 |
118 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.53077260 |
119 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.52844205 |
120 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.51412446 |
121 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.50640593 |
122 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.50622949 |
123 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.50166777 |
124 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.49911698 |
125 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.47364703 |
126 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.47296858 |
127 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.46991089 |
128 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.45919406 |
129 | GATA2_19941826_ChIP-Seq_K562_Human | 0.45426700 |
130 | GATA1_19941826_ChIP-Seq_K562_Human | 0.45188505 |
131 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.44780470 |
132 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.43903414 |
133 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.43053271 |
134 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.42767222 |
135 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.42637311 |
136 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.42474298 |
137 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.41936410 |
138 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.41418622 |
139 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.40639646 |
140 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.40481721 |
141 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.40396030 |
142 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.39703523 |
143 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.39353117 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 7.81857824 |
2 | MP0005360_urolithiasis | 6.77068991 |
3 | MP0005365_abnormal_bile_salt | 6.04459136 |
4 | MP0005085_abnormal_gallbladder_physiolo | 6.03090870 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 5.76439969 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.11680841 |
7 | MP0010329_abnormal_lipoprotein_level | 3.61512252 |
8 | MP0003252_abnormal_bile_duct | 3.49165731 |
9 | MP0009840_abnormal_foam_cell | 3.28392131 |
10 | MP0005083_abnormal_biliary_tract | 2.92766691 |
11 | MP0005332_abnormal_amino_acid | 2.85231709 |
12 | MP0001666_abnormal_nutrient_absorption | 2.63910686 |
13 | MP0003195_calcinosis | 2.47512172 |
14 | MP0003191_abnormal_cellular_cholesterol | 2.35380407 |
15 | MP0004019_abnormal_vitamin_homeostasis | 2.31325691 |
16 | MP0002118_abnormal_lipid_homeostasis | 2.05901910 |
17 | MP0000609_abnormal_liver_physiology | 2.04328815 |
18 | MP0003186_abnormal_redox_activity | 1.97870812 |
19 | MP0005319_abnormal_enzyme/_coenzyme | 1.85801578 |
20 | MP0005058_abnormal_lysosome_morphology | 1.76173154 |
21 | MP0002254_reproductive_system_inflammat | 1.71906742 |
22 | MP0002138_abnormal_hepatobiliary_system | 1.70404159 |
23 | MP0003868_abnormal_feces_composition | 1.66427342 |
24 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.55623198 |
25 | MP0001764_abnormal_homeostasis | 1.54416513 |
26 | MP0005647_abnormal_sex_gland | 1.46552664 |
27 | MP0003011_delayed_dark_adaptation | 1.39591916 |
28 | MP0009643_abnormal_urine_homeostasis | 1.39058740 |
29 | MP0009697_abnormal_copulation | 1.35491599 |
30 | MP0003656_abnormal_erythrocyte_physiolo | 1.31883187 |
31 | MP0005451_abnormal_body_composition | 1.19916047 |
32 | MP0003705_abnormal_hypodermis_morpholog | 1.17992776 |
33 | MP0003879_abnormal_hair_cell | 1.11420183 |
34 | MP0009764_decreased_sensitivity_to | 1.10730900 |
35 | MP0000598_abnormal_liver_morphology | 1.07714917 |
36 | MP0010155_abnormal_intestine_physiology | 1.07367815 |
37 | MP0005636_abnormal_mineral_homeostasis | 1.03429946 |
38 | MP0000678_abnormal_parathyroid_gland | 1.03428998 |
39 | MP0009379_abnormal_foot_pigmentation | 1.01584839 |
40 | MP0000604_amyloidosis | 1.00089177 |
41 | MP0005408_hypopigmentation | 0.98959766 |
42 | MP0010368_abnormal_lymphatic_system | 0.98568720 |
43 | MP0008004_abnormal_stomach_pH | 0.96223648 |
44 | MP0002249_abnormal_larynx_morphology | 0.92293350 |
45 | MP0009763_increased_sensitivity_to | 0.92017658 |
46 | MP0002132_abnormal_respiratory_system | 0.90736734 |
47 | MP0003690_abnormal_glial_cell | 0.90086614 |
48 | MP0009053_abnormal_anal_canal | 0.89172784 |
49 | MP0005670_abnormal_white_adipose | 0.87473899 |
50 | MP0003183_abnormal_peptide_metabolism | 0.84217805 |
51 | MP0005376_homeostasis/metabolism_phenot | 0.83080332 |
52 | MP0001663_abnormal_digestive_system | 0.81603300 |
53 | MP0009642_abnormal_blood_homeostasis | 0.81526555 |
54 | MP0003866_abnormal_defecation | 0.80963257 |
55 | MP0005501_abnormal_skin_physiology | 0.78974277 |
56 | MP0009765_abnormal_xenobiotic_induced | 0.78880135 |
57 | MP0004185_abnormal_adipocyte_glucose | 0.78610722 |
58 | MP0008469_abnormal_protein_level | 0.78426320 |
59 | MP0001756_abnormal_urination | 0.76368804 |
60 | MP0001664_abnormal_digestion | 0.75279532 |
61 | MP0000249_abnormal_blood_vessel | 0.74469871 |
62 | MP0002876_abnormal_thyroid_physiology | 0.72760544 |
63 | MP0005084_abnormal_gallbladder_morpholo | 0.71364852 |
64 | MP0000490_abnormal_crypts_of | 0.71133564 |
65 | MP0005266_abnormal_metabolism | 0.70947555 |
66 | MP0006036_abnormal_mitochondrial_physio | 0.70929854 |
67 | MP0005381_digestive/alimentary_phenotyp | 0.70333586 |
68 | MP0000477_abnormal_intestine_morphology | 0.70025943 |
69 | MP0003329_amyloid_beta_deposits | 0.69655854 |
70 | MP0005220_abnormal_exocrine_pancreas | 0.69519197 |
71 | MP0004147_increased_porphyrin_level | 0.69137606 |
72 | MP0004782_abnormal_surfactant_physiolog | 0.67742481 |
73 | MP0005334_abnormal_fat_pad | 0.66340762 |
74 | MP0002971_abnormal_brown_adipose | 0.66264439 |
75 | MP0002078_abnormal_glucose_homeostasis | 0.66204478 |
76 | MP0002089_abnormal_postnatal_growth/wei | 0.65562267 |
77 | MP0004043_abnormal_pH_regulation | 0.64994652 |
78 | MP0005375_adipose_tissue_phenotype | 0.64866797 |
79 | MP0004272_abnormal_basement_membrane | 0.64698111 |
80 | MP0004858_abnormal_nervous_system | 0.63081890 |
81 | MP0000467_abnormal_esophagus_morphology | 0.63066127 |
82 | MP0003075_altered_response_to | 0.62062937 |
83 | MP0004264_abnormal_extraembryonic_tissu | 0.61970222 |
84 | MP0004130_abnormal_muscle_cell | 0.61542078 |
85 | MP0008789_abnormal_olfactory_epithelium | 0.59893448 |
86 | MP0008260_abnormal_autophagy | 0.59465968 |
87 | MP0010352_gastrointestinal_tract_polyps | 0.59434152 |
88 | MP0000639_abnormal_adrenal_gland | 0.58860454 |
89 | MP0002136_abnormal_kidney_physiology | 0.58473495 |
90 | MP0000858_altered_metastatic_potential | 0.58172753 |
91 | MP0005023_abnormal_wound_healing | 0.57746518 |
92 | MP0009333_abnormal_splenocyte_physiolog | 0.57657918 |
93 | MP0005248_abnormal_Harderian_gland | 0.57318201 |
94 | MP0005535_abnormal_body_temperature | 0.56476716 |
95 | MP0008872_abnormal_physiological_respon | 0.56467807 |
96 | MP0001984_abnormal_olfaction | 0.55981831 |
97 | MP0005165_increased_susceptibility_to | 0.55967313 |
98 | MP0003638_abnormal_response/metabolism_ | 0.55729321 |
99 | MP0003566_abnormal_cell_adhesion | 0.55672626 |
100 | MP0003436_decreased_susceptibility_to | 0.55205955 |
101 | MP0001845_abnormal_inflammatory_respons | 0.53759413 |
102 | MP0001849_ear_inflammation | 0.52815581 |
103 | MP0003303_peritoneal_inflammation | 0.52653156 |
104 | MP0009785_altered_susceptibility_to | 0.51594905 |
105 | MP0005394_taste/olfaction_phenotype | 0.50747679 |
106 | MP0005499_abnormal_olfactory_system | 0.50747679 |
107 | MP0000566_synostosis | 0.50118019 |
108 | MP0004883_abnormal_blood_vessel | 0.49358784 |
109 | MP0002796_impaired_skin_barrier | 0.47274779 |
110 | MP0010234_abnormal_vibrissa_follicle | 0.45955286 |
111 | MP0001853_heart_inflammation | 0.45330368 |
112 | MP0009384_cardiac_valve_regurgitation | 0.45092715 |
113 | MP0005166_decreased_susceptibility_to | 0.44831932 |
114 | MP0005448_abnormal_energy_balance | 0.44630835 |
115 | MP0005395_other_phenotype | 0.44161815 |
116 | MP0005666_abnormal_adipose_tissue | 0.42276257 |
117 | MP0003953_abnormal_hormone_level | 0.41763115 |
118 | MP0003724_increased_susceptibility_to | 0.41748275 |
119 | MP0002928_abnormal_bile_duct | 0.41098119 |
120 | MP0005464_abnormal_platelet_physiology | 0.40953112 |
121 | MP0003718_maternal_effect | 0.39378406 |
122 | MP0009115_abnormal_fat_cell | 0.39279505 |
123 | MP0001661_extended_life_span | 0.38635580 |
124 | MP0003453_abnormal_keratinocyte_physiol | 0.38580954 |
125 | MP0010030_abnormal_orbit_morphology | 0.38006638 |
126 | MP0005164_abnormal_response_to | 0.37986957 |
127 | MP0001346_abnormal_lacrimal_gland | 0.37388536 |
128 | MP0008873_increased_physiological_sensi | 0.36460000 |
129 | MP0001881_abnormal_mammary_gland | 0.35844259 |
130 | MP0000579_abnormal_nail_morphology | 0.35843010 |
131 | MP0002295_abnormal_pulmonary_circulatio | 0.34554527 |
132 | MP0002060_abnormal_skin_morphology | 0.34411827 |
133 | MP0002098_abnormal_vibrissa_morphology | 0.33811624 |
134 | MP0006035_abnormal_mitochondrial_morpho | 0.33783151 |
135 | MP0002822_catalepsy | 0.32913802 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.01762970 |
2 | Intrahepatic cholestasis (HP:0001406) | 6.93127006 |
3 | Deep venous thrombosis (HP:0002625) | 6.86439339 |
4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.48965170 |
5 | Xanthomatosis (HP:0000991) | 6.12754310 |
6 | Prolonged partial thromboplastin time (HP:0003645) | 6.09516461 |
7 | Hypobetalipoproteinemia (HP:0003563) | 5.85594385 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.44737062 |
9 | Complement deficiency (HP:0004431) | 4.77139348 |
10 | Hypolipoproteinemia (HP:0010981) | 4.68257657 |
11 | Hyperammonemia (HP:0001987) | 4.64596591 |
12 | Hyperglycinuria (HP:0003108) | 4.56265307 |
13 | Hyperglycinemia (HP:0002154) | 4.48211963 |
14 | Joint hemorrhage (HP:0005261) | 4.44924217 |
15 | Hypoalphalipoproteinemia (HP:0003233) | 4.34956894 |
16 | Ketosis (HP:0001946) | 4.33675468 |
17 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.32490741 |
18 | Abnormality of glycine metabolism (HP:0010895) | 4.32490741 |
19 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.26113263 |
20 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.19813289 |
21 | Epidermoid cyst (HP:0200040) | 4.18956394 |
22 | Fat malabsorption (HP:0002630) | 4.18189019 |
23 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.16954894 |
24 | Abnormality of methionine metabolism (HP:0010901) | 4.14858571 |
25 | Abnormality of the common coagulation pathway (HP:0010990) | 4.06934551 |
26 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.01793068 |
27 | Hypoglycemic coma (HP:0001325) | 3.91732162 |
28 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.83658754 |
29 | Abnormality of the intrinsic pathway (HP:0010989) | 3.68651050 |
30 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.60414911 |
31 | Hypercholesterolemia (HP:0003124) | 3.57202694 |
32 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.54047082 |
33 | Conjugated hyperbilirubinemia (HP:0002908) | 3.47940660 |
34 | Abnormality of complement system (HP:0005339) | 3.46662847 |
35 | Purpura (HP:0000979) | 3.38916097 |
36 | Steatorrhea (HP:0002570) | 3.36477182 |
37 | Ketoacidosis (HP:0001993) | 3.23561124 |
38 | Hyperbilirubinemia (HP:0002904) | 3.22545243 |
39 | Hepatocellular carcinoma (HP:0001402) | 3.13412414 |
40 | Delayed CNS myelination (HP:0002188) | 3.13169500 |
41 | Abnormality of serum amino acid levels (HP:0003112) | 3.04529014 |
42 | Abnormality of nucleobase metabolism (HP:0010932) | 2.97970574 |
43 | Nephritis (HP:0000123) | 2.89359791 |
44 | Metabolic acidosis (HP:0001942) | 2.88718822 |
45 | Myocardial infarction (HP:0001658) | 2.86719756 |
46 | Gout (HP:0001997) | 2.80235004 |
47 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.77543376 |
48 | Dicarboxylic aciduria (HP:0003215) | 2.77543376 |
49 | Spontaneous abortion (HP:0005268) | 2.72280256 |
50 | Vascular calcification (HP:0004934) | 2.72265342 |
51 | Lethargy (HP:0001254) | 2.71014682 |
52 | Abnormality of purine metabolism (HP:0004352) | 2.69932320 |
53 | Petechiae (HP:0000967) | 2.66317251 |
54 | Hypochromic microcytic anemia (HP:0004840) | 2.59122250 |
55 | Spastic diplegia (HP:0001264) | 2.57887532 |
56 | Esophageal varix (HP:0002040) | 2.48362036 |
57 | Amyloidosis (HP:0011034) | 2.44443188 |
58 | Reduced antithrombin III activity (HP:0001976) | 2.42724169 |
59 | Abnormality of the Achilles tendon (HP:0005109) | 2.42504040 |
60 | Systemic lupus erythematosus (HP:0002725) | 2.39690246 |
61 | Cardiovascular calcification (HP:0011915) | 2.38212151 |
62 | Sensorimotor neuropathy (HP:0007141) | 2.35376459 |
63 | Generalized aminoaciduria (HP:0002909) | 2.33941332 |
64 | Glycosuria (HP:0003076) | 2.31100991 |
65 | Abnormality of urine glucose concentration (HP:0011016) | 2.31100991 |
66 | Cerebral edema (HP:0002181) | 2.29288601 |
67 | Hypoglycemic seizures (HP:0002173) | 2.28413026 |
68 | Pancreatitis (HP:0001733) | 2.26881081 |
69 | Brushfield spots (HP:0001088) | 2.25237495 |
70 | Cerebral palsy (HP:0100021) | 2.24489557 |
71 | Irritability (HP:0000737) | 2.24280981 |
72 | Skin nodule (HP:0200036) | 2.23849052 |
73 | Ileus (HP:0002595) | 2.21790289 |
74 | Malnutrition (HP:0004395) | 2.21474903 |
75 | Abnormal gallbladder morphology (HP:0012437) | 2.20711226 |
76 | Neonatal onset (HP:0003623) | 2.20187083 |
77 | Late onset (HP:0003584) | 2.18574331 |
78 | Hyperphosphaturia (HP:0003109) | 2.18291678 |
79 | Acanthocytosis (HP:0001927) | 2.18139365 |
80 | Vomiting (HP:0002013) | 2.17926149 |
81 | Cholelithiasis (HP:0001081) | 2.17713363 |
82 | Hydroxyprolinuria (HP:0003080) | 2.14489100 |
83 | Abnormality of proline metabolism (HP:0010907) | 2.14489100 |
84 | Rickets (HP:0002748) | 2.14417405 |
85 | Abnormal cartilage morphology (HP:0002763) | 2.14167989 |
86 | Abdominal distention (HP:0003270) | 2.13494303 |
87 | Proximal tubulopathy (HP:0000114) | 2.12844390 |
88 | Renal cortical cysts (HP:0000803) | 2.12620953 |
89 | Osteomalacia (HP:0002749) | 2.12000505 |
90 | Mitral stenosis (HP:0001718) | 2.11396631 |
91 | Abnormal tarsal ossification (HP:0008369) | 2.10910449 |
92 | Nausea (HP:0002018) | 2.08847387 |
93 | Increased mean platelet volume (HP:0011877) | 2.08514556 |
94 | Increased serum ferritin (HP:0003281) | 2.07201066 |
95 | Abnormal enzyme/coenzyme activity (HP:0012379) | 2.06119142 |
96 | Enlarged kidneys (HP:0000105) | 2.04636847 |
97 | Flat acetabular roof (HP:0003180) | 2.04321987 |
98 | Hypophosphatemia (HP:0002148) | 2.04013385 |
99 | Thrombophlebitis (HP:0004418) | 2.01821698 |
100 | Impaired platelet aggregation (HP:0003540) | 2.01743641 |
101 | Abnormal platelet function (HP:0011869) | 2.01743641 |
102 | Abnormality of alkaline phosphatase activity (HP:0004379) | 2.01285739 |
103 | Elevated alkaline phosphatase (HP:0003155) | 2.00999129 |
104 | Opisthotonus (HP:0002179) | 1.99458926 |
105 | Abnormality of carpal bone ossification (HP:0006257) | 1.99367249 |
106 | Glomerulonephritis (HP:0000099) | 1.98862684 |
107 | Alkalosis (HP:0001948) | 1.98370411 |
108 | Abnormal gallbladder physiology (HP:0012438) | 1.97870213 |
109 | Cholecystitis (HP:0001082) | 1.97870213 |
110 | Epistaxis (HP:0000421) | 1.97150328 |
111 | Gingival bleeding (HP:0000225) | 1.96843621 |
112 | Abnormal urine phosphate concentration (HP:0012599) | 1.96476775 |
113 | Polycythemia (HP:0001901) | 1.95710515 |
114 | Abnormal platelet volume (HP:0011876) | 1.95528943 |
115 | Hyperactive renin-angiotensin system (HP:0000841) | 1.93914463 |
116 | Hemorrhage of the eye (HP:0011885) | 1.91435413 |
117 | Back pain (HP:0003418) | 1.91140570 |
118 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.90566226 |
119 | Menorrhagia (HP:0000132) | 1.89973325 |
120 | Hypertriglyceridemia (HP:0002155) | 1.89479651 |
121 | Widely patent fontanelles and sutures (HP:0004492) | 1.85985561 |
122 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.85563494 |
123 | Abnormality of the gallbladder (HP:0005264) | 1.85275067 |
124 | Pseudobulbar signs (HP:0002200) | 1.85159135 |
125 | Abnormality of iron homeostasis (HP:0011031) | 1.84725091 |
126 | Hypophosphatemic rickets (HP:0004912) | 1.84183449 |
127 | Abnormality of vitamin metabolism (HP:0100508) | 1.83634212 |
128 | Elevated hepatic transaminases (HP:0002910) | 1.83605196 |
129 | Poikilocytosis (HP:0004447) | 1.81825468 |
130 | Increased purine levels (HP:0004368) | 1.80720382 |
131 | Hyperuricemia (HP:0002149) | 1.80720382 |
132 | Vertebral compression fractures (HP:0002953) | 1.75888821 |
133 | Prolonged bleeding time (HP:0003010) | 1.74603369 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 7.41642294 |
2 | ERN1 | 4.55880251 |
3 | SIK1 | 4.48105279 |
4 | SMG1 | 3.46104830 |
5 | FGFR4 | 3.44506952 |
6 | TAOK3 | 2.88905109 |
7 | NME2 | 2.76798351 |
8 | INSRR | 2.39275464 |
9 | TRIB3 | 2.38955013 |
10 | ERBB4 | 2.20746927 |
11 | MST1R | 2.17213917 |
12 | MAP3K3 | 2.08444747 |
13 | PKN2 | 1.95779407 |
14 | LATS1 | 1.88402145 |
15 | TESK1 | 1.84472265 |
16 | TESK2 | 1.74520747 |
17 | PIM2 | 1.73396282 |
18 | PRPF4B | 1.67184668 |
19 | MAP2K3 | 1.64490197 |
20 | PINK1 | 1.60347672 |
21 | RIPK1 | 1.56996352 |
22 | MAPK15 | 1.52283117 |
23 | MAPK11 | 1.47989129 |
24 | VRK2 | 1.47232621 |
25 | PTK6 | 1.47127240 |
26 | FLT3 | 1.45031210 |
27 | MAP3K12 | 1.42129181 |
28 | DAPK2 | 1.41397875 |
29 | MAP2K4 | 1.41063378 |
30 | PIK3CG | 1.37641082 |
31 | STK16 | 1.33336955 |
32 | ARAF | 1.32808661 |
33 | FRK | 1.30051639 |
34 | PRKG2 | 1.28566114 |
35 | LMTK2 | 1.26044345 |
36 | TAOK2 | 1.24892749 |
37 | STK38L | 1.24863936 |
38 | TYK2 | 1.23550161 |
39 | EPHB1 | 1.22858244 |
40 | SGK3 | 1.22017104 |
41 | GRK6 | 1.17020587 |
42 | SGK2 | 1.13594120 |
43 | MAP2K2 | 1.12686208 |
44 | ACVR1B | 1.10146087 |
45 | ERBB2 | 1.04841790 |
46 | ILK | 1.04764904 |
47 | NEK9 | 1.04524983 |
48 | CDK6 | 1.04406194 |
49 | MAP3K2 | 1.03007691 |
50 | RIPK4 | 1.01985838 |
51 | ABL2 | 1.01810471 |
52 | MAP3K11 | 1.00864422 |
53 | PAK4 | 1.00554991 |
54 | MAP2K6 | 1.00506888 |
55 | DAPK3 | 0.96818548 |
56 | SGK494 | 0.95768630 |
57 | SGK223 | 0.95768630 |
58 | JAK2 | 0.95406534 |
59 | MAP3K7 | 0.94346235 |
60 | RPS6KB2 | 0.91129714 |
61 | FGFR2 | 0.88822311 |
62 | EPHA3 | 0.88410864 |
63 | ICK | 0.86290191 |
64 | EPHB2 | 0.86252396 |
65 | MET | 0.85466462 |
66 | EPHA2 | 0.83122271 |
67 | PRKD3 | 0.82123083 |
68 | MAPK12 | 0.81916415 |
69 | BRAF | 0.80934477 |
70 | MAP3K10 | 0.80239368 |
71 | PRKAA2 | 0.79765868 |
72 | MAP2K1 | 0.77482305 |
73 | MAP3K14 | 0.74779307 |
74 | KDR | 0.74479748 |
75 | DAPK1 | 0.73863831 |
76 | PDK1 | 0.73391967 |
77 | TBK1 | 0.72423795 |
78 | MAPK4 | 0.71749753 |
79 | BLK | 0.71524092 |
80 | MAP4K1 | 0.68838808 |
81 | PBK | 0.66543620 |
82 | PRKCZ | 0.65830626 |
83 | ZAP70 | 0.65240127 |
84 | CAMK2G | 0.65056467 |
85 | GRK5 | 0.64919851 |
86 | JAK1 | 0.64295166 |
87 | CDC42BPA | 0.63582142 |
88 | EPHA4 | 0.63434383 |
89 | TAOK1 | 0.63081605 |
90 | LRRK2 | 0.61016918 |
91 | ADRBK2 | 0.60791091 |
92 | MAPK7 | 0.60109525 |
93 | GSK3A | 0.59778105 |
94 | MAPKAPK3 | 0.54152921 |
95 | MAP3K8 | 0.53230495 |
96 | PTK2 | 0.53080991 |
97 | PRKACG | 0.52577695 |
98 | TIE1 | 0.50827355 |
99 | DDR2 | 0.50587318 |
100 | IKBKE | 0.50293341 |
101 | MATK | 0.49422135 |
102 | PDK2 | 0.48837161 |
103 | MST4 | 0.48656295 |
104 | GRK1 | 0.47295825 |
105 | PDPK1 | 0.45991086 |
106 | DYRK1B | 0.45493492 |
107 | CAMK1D | 0.44923720 |
108 | SCYL2 | 0.42843173 |
109 | MYLK | 0.42704691 |
110 | AKT2 | 0.42363929 |
111 | PRKAA1 | 0.42330081 |
112 | PHKG2 | 0.41773438 |
113 | PHKG1 | 0.41773438 |
114 | PRKD2 | 0.40460833 |
115 | PRKCI | 0.40024840 |
116 | EEF2K | 0.38694200 |
117 | IRAK3 | 0.37515352 |
118 | FGFR3 | 0.36594250 |
119 | PRKCQ | 0.36592046 |
120 | MUSK | 0.36062692 |
121 | PDK4 | 0.35544893 |
122 | PDK3 | 0.35544893 |
123 | MAPKAPK2 | 0.34503468 |
124 | HIPK2 | 0.34367972 |
125 | KSR2 | 0.34247025 |
126 | IGF1R | 0.34097503 |
127 | FER | 0.33383958 |
128 | SRC | 0.33186345 |
129 | IRAK4 | 0.32860705 |
130 | MAP3K1 | 0.32801182 |
131 | PIK3CA | 0.32365976 |
132 | NLK | 0.32063001 |
133 | CAMK2D | 0.31969422 |
134 | CAMK4 | 0.30935841 |
135 | CDK7 | 0.30755378 |
136 | PAK1 | 0.30645858 |
137 | ZAK | 0.30379846 |
138 | CDK9 | 0.30326895 |
139 | CSK | 0.30284572 |
140 | TGFBR2 | 0.30065014 |
141 | MAP3K5 | 0.30015382 |
142 | IRAK2 | 0.29993100 |
143 | CSF1R | 0.28900422 |
144 | PRKCD | 0.28589015 |
145 | PRKCA | 0.27799479 |
146 | IKBKB | 0.27718965 |
147 | EIF2AK1 | 0.27714411 |
148 | AKT3 | 0.26289291 |
149 | BMX | 0.23982052 |
150 | MTOR | 0.21008097 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.07629059 |
2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.63839391 |
3 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.58092304 |
4 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.80729328 |
5 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.78137385 |
6 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.73287779 |
7 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.68753978 |
8 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.58752568 |
9 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.53607994 |
10 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.51506057 |
11 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.46856229 |
12 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.45358828 |
13 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.44386896 |
14 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.43605368 |
15 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.41223067 |
16 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.40356116 |
17 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.15952425 |
18 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.11545224 |
19 | Peroxisome_Homo sapiens_hsa04146 | 2.09898151 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.01578882 |
21 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.85520857 |
22 | Histidine metabolism_Homo sapiens_hsa00340 | 1.84420545 |
23 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.83554392 |
24 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.82518927 |
25 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.81071287 |
26 | Retinol metabolism_Homo sapiens_hsa00830 | 1.80228401 |
27 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.77432576 |
28 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.60735019 |
29 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.55372809 |
30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.51294110 |
31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.50846765 |
32 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.47725599 |
33 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.47519468 |
34 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.47406948 |
35 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.40076076 |
36 | Bile secretion_Homo sapiens_hsa04976 | 1.38636840 |
37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.38581922 |
38 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.34600651 |
39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.32834308 |
40 | * Sulfur metabolism_Homo sapiens_hsa00920 | 1.31885606 |
41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.22759846 |
42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.22674655 |
43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.22456276 |
44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.19980375 |
45 | * Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19209740 |
46 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.17944639 |
47 | Carbon metabolism_Homo sapiens_hsa01200 | 1.15605588 |
48 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.14983521 |
49 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.10516449 |
50 | ABC transporters_Homo sapiens_hsa02010 | 1.07982223 |
51 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.03630903 |
52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.00082472 |
53 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.95610134 |
54 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.93647314 |
55 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.93023788 |
56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.83662515 |
57 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.82935808 |
58 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.79666636 |
59 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.79199077 |
60 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.78289234 |
61 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.77399353 |
62 | Other glycan degradation_Homo sapiens_hsa00511 | 0.75399806 |
63 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.73222849 |
64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.70820948 |
65 | Lysine degradation_Homo sapiens_hsa00310 | 0.67433141 |
66 | * Sulfur relay system_Homo sapiens_hsa04122 | 0.65838571 |
67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.57053380 |
68 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.55000462 |
69 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.48496629 |
70 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.46601899 |
71 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.45461747 |
72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30983499 |
73 | Prion diseases_Homo sapiens_hsa05020 | 0.27674209 |
74 | Pertussis_Homo sapiens_hsa05133 | 0.23364578 |
75 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23237546 |
76 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.22563201 |
77 | Insulin resistance_Homo sapiens_hsa04931 | 0.21246700 |
78 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.17919292 |
79 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.16656559 |
80 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.14680694 |
81 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.09262820 |
82 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.07312524 |
83 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.07210893 |
84 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.04477667 |
85 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.02614760 |
86 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.00042126 |
87 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.2217301 |
88 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.2127888 |
89 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | -0.2086529 |
90 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1875599 |
91 | Bladder cancer_Homo sapiens_hsa05219 | -0.1859048 |
92 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1526915 |
93 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.1396804 |
94 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1354167 |
95 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1352113 |
96 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1316413 |
97 | Circadian rhythm_Homo sapiens_hsa04710 | -0.1310744 |
98 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1305087 |
99 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1183805 |
100 | Hepatitis C_Homo sapiens_hsa05160 | -0.1053903 |
101 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | -0.1019859 |
102 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0765104 |
103 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | -0.0639494 |
104 | Mineral absorption_Homo sapiens_hsa04978 | -0.0575306 |
105 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | -0.0562343 |
106 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0407436 |
107 | Lysosome_Homo sapiens_hsa04142 | -0.0375543 |
108 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0338590 |
109 | Amoebiasis_Homo sapiens_hsa05146 | -0.0265838 |
110 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.0088907 |