TSTA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.80578556
2DNA deamination (GO:0045006)8.23538349
3transcription from mitochondrial promoter (GO:0006390)7.53016116
4proline metabolic process (GO:0006560)7.37047879
5replication fork processing (GO:0031297)6.75500747
6embryonic process involved in female pregnancy (GO:0060136)6.51912046
7positive regulation of protein homooligomerization (GO:0032464)5.87421903
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.63140940
9oxidative demethylation (GO:0070989)5.43609249
10formation of translation preinitiation complex (GO:0001731)5.32959354
11viral mRNA export from host cell nucleus (GO:0046784)5.27581670
12regulation of integrin activation (GO:0033623)5.05046988
13establishment of apical/basal cell polarity (GO:0035089)5.04699709
14regulation of protein homooligomerization (GO:0032462)4.98371647
15somatic diversification of immune receptors via somatic mutation (GO:0002566)4.95773974
16somatic hypermutation of immunoglobulin genes (GO:0016446)4.95773974
17mitochondrial DNA metabolic process (GO:0032042)4.90642038
18COPI coating of Golgi vesicle (GO:0048205)4.80806493
19Golgi transport vesicle coating (GO:0048200)4.80806493
20telomere maintenance via semi-conservative replication (GO:0032201)4.70037277
21poly(A)+ mRNA export from nucleus (GO:0016973)4.59273799
22mitotic G1 DNA damage checkpoint (GO:0031571)4.46188498
23DNA strand renaturation (GO:0000733)4.44171231
24* GDP-mannose metabolic process (GO:0019673)4.41466736
25establishment or maintenance of monopolar cell polarity (GO:0061339)4.35644569
26establishment of monopolar cell polarity (GO:0061162)4.35644569
27regulation of translational fidelity (GO:0006450)4.16283820
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.16015410
29base-excision repair (GO:0006284)4.15778238
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.12747313
31cellular response to zinc ion (GO:0071294)4.03858803
32mitochondrial RNA metabolic process (GO:0000959)4.02823182
33mRNA cleavage (GO:0006379)3.96872563
34DNA strand elongation involved in DNA replication (GO:0006271)3.96485794
35negative regulation of JAK-STAT cascade (GO:0046426)3.93050775
36telomere maintenance via recombination (GO:0000722)3.89873140
37mitotic G1/S transition checkpoint (GO:0044819)3.87418120
38glutamine family amino acid biosynthetic process (GO:0009084)3.86968184
39protein maturation by protein folding (GO:0022417)3.86399619
40DNA integration (GO:0015074)3.85820725
41maturation of 5.8S rRNA (GO:0000460)3.82966175
42negative regulation of cell cycle arrest (GO:0071157)3.80028384
43protoporphyrinogen IX metabolic process (GO:0046501)3.77398241
44cullin deneddylation (GO:0010388)3.77271574
45base-excision repair, AP site formation (GO:0006285)3.77136451
46DNA strand elongation (GO:0022616)3.71079884
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.70616863
48G1 DNA damage checkpoint (GO:0044783)3.70313891
49non-recombinational repair (GO:0000726)3.67877190
50double-strand break repair via nonhomologous end joining (GO:0006303)3.67877190
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.62410070
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.61084043
53cellular response to ATP (GO:0071318)3.60097824
54positive regulation of Cdc42 GTPase activity (GO:0043089)3.59961705
55DNA double-strand break processing (GO:0000729)3.54984271
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.54498602
57positive regulation of protein oligomerization (GO:0032461)3.49212834
58protein deneddylation (GO:0000338)3.46490669
59positive regulation of developmental pigmentation (GO:0048087)3.42082369
60termination of RNA polymerase II transcription (GO:0006369)3.40877568
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.39403128
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38944915
63meiotic chromosome segregation (GO:0045132)3.38261855
64pentose-phosphate shunt (GO:0006098)3.37723474
65embryonic placenta development (GO:0001892)3.37604444
66negative regulation of fatty acid biosynthetic process (GO:0045717)3.36222594
67protoporphyrinogen IX biosynthetic process (GO:0006782)3.35325225
68mitotic recombination (GO:0006312)3.31044399
69heme biosynthetic process (GO:0006783)3.26879517
70telomere maintenance via telomere lengthening (GO:0010833)3.24786125
71DNA topological change (GO:0006265)3.22936523
72DNA ligation (GO:0006266)3.19451935
73negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.13977320
74kinetochore assembly (GO:0051382)3.11628860
75dosage compensation (GO:0007549)3.11138000
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10272385
77negative regulation of mRNA processing (GO:0050686)3.09937836
78regulation of protein oligomerization (GO:0032459)3.08103569
79NADPH regeneration (GO:0006740)3.07629521
80positive regulation of DNA repair (GO:0045739)3.07538580
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.06832753
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06832753
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06832753
84desmosome organization (GO:0002934)3.06827552
85nucleobase-containing small molecule interconversion (GO:0015949)3.06657794
86pyrimidine nucleotide catabolic process (GO:0006244)3.06287417
87DNA demethylation (GO:0080111)3.05570888
88NADH metabolic process (GO:0006734)3.05015955
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.04149873
90glucose catabolic process (GO:0006007)3.01659012
91positive regulation by host of viral transcription (GO:0043923)3.00183806
92negative regulation of protein oligomerization (GO:0032460)2.99503575
93heme metabolic process (GO:0042168)2.98702598
94pseudouridine synthesis (GO:0001522)2.98221305
95regulation of sister chromatid cohesion (GO:0007063)2.98221094
96negative regulation of RNA splicing (GO:0033119)2.98045105
97mitochondrial DNA replication (GO:0006264)2.97977366
98regulation of double-strand break repair (GO:2000779)2.94468447
99nodal signaling pathway (GO:0038092)2.93191999
100sulfur amino acid catabolic process (GO:0000098)2.90777764
101virion assembly (GO:0019068)2.90066153
102urea cycle (GO:0000050)2.87361662
103nuclear envelope reassembly (GO:0031468)2.86273003
104mitotic nuclear envelope reassembly (GO:0007084)2.86273003
105regulation of posttranscriptional gene silencing (GO:0060147)2.82170613
106regulation of gene silencing by miRNA (GO:0060964)2.82170613
107regulation of gene silencing by RNA (GO:0060966)2.82170613
108trophectodermal cell differentiation (GO:0001829)2.82140035
109proteasome assembly (GO:0043248)2.81790513
110porphyrin-containing compound biosynthetic process (GO:0006779)2.81754223
111oxidative phosphorylation (GO:0006119)2.81332979
112embryonic camera-type eye development (GO:0031076)2.79051426
113ribosome biogenesis (GO:0042254)2.78884204
114apoptotic process involved in morphogenesis (GO:0060561)2.78590619
115viral protein processing (GO:0019082)2.76224350
116single strand break repair (GO:0000012)2.76221201
117modulation by virus of host process (GO:0019054)2.74856293
118histone H4-K12 acetylation (GO:0043983)2.73776502
119spliceosomal snRNP assembly (GO:0000387)2.73675764
120protein retention in ER lumen (GO:0006621)2.73035678
121regulation of DNA damage checkpoint (GO:2000001)2.72156198
122nucleotide salvage (GO:0043173)2.69553873
123glial cell migration (GO:0008347)2.69397328
124NIK/NF-kappaB signaling (GO:0038061)2.68666411
125face development (GO:0060324)2.68654714
126pentose metabolic process (GO:0019321)2.67968264
127urea metabolic process (GO:0019627)2.65635966
1283-UTR-mediated mRNA stabilization (GO:0070935)2.64673851
129porphyrin-containing compound metabolic process (GO:0006778)2.62620074
130nucleoside diphosphate biosynthetic process (GO:0009133)2.62287625
131pinocytosis (GO:0006907)2.61218091
132positive regulation of keratinocyte differentiation (GO:0045618)2.54671125
133glucose 6-phosphate metabolic process (GO:0051156)2.54206712
134modulation by symbiont of host cellular process (GO:0044068)2.50729384
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50547652
136negative regulation of cell size (GO:0045792)2.50380292
137nitrogen cycle metabolic process (GO:0071941)2.50340974
138maternal placenta development (GO:0001893)2.50307746
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.49985924
140guanosine-containing compound biosynthetic process (GO:1901070)2.46779531
141activation of Rac GTPase activity (GO:0032863)2.44664742
142regulation of superoxide anion generation (GO:0032928)2.42084296
143regulation of water loss via skin (GO:0033561)2.41567260
144peptidyl-arginine omega-N-methylation (GO:0035247)2.41149484
145barbed-end actin filament capping (GO:0051016)2.40190785
146deoxyribose phosphate biosynthetic process (GO:0046385)2.39741029
1472-deoxyribonucleotide biosynthetic process (GO:0009265)2.39741029
148folic acid metabolic process (GO:0046655)2.39324199
149cellular response to virus (GO:0098586)2.37708505
150UV protection (GO:0009650)2.37542560
151tetrapyrrole biosynthetic process (GO:0033014)2.36645592
152negative regulation of viral release from host cell (GO:1902187)2.35535838
153hemoglobin metabolic process (GO:0020027)2.34177012
154positive regulation of epidermal cell differentiation (GO:0045606)2.34097440
155pyrimidine-containing compound salvage (GO:0008655)2.32684717
156pyrimidine nucleoside salvage (GO:0043097)2.32684717
157hemidesmosome assembly (GO:0031581)2.31232514
158antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.31052911
159negative regulation of erythrocyte differentiation (GO:0045647)2.28764691
160protein localization to endosome (GO:0036010)2.27606576
161amyloid precursor protein catabolic process (GO:0042987)2.26787473
162negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.25658218
163mannose metabolic process (GO:0006013)2.24447945
164glutathione biosynthetic process (GO:0006750)2.23186566
165positive regulation of pseudopodium assembly (GO:0031274)2.20133601
166erythrocyte maturation (GO:0043249)2.18922287
167activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.18565064
168regulation of cellular amino acid metabolic process (GO:0006521)2.18422163
169endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.17514426
170chaperone mediated protein folding requiring cofactor (GO:0051085)2.17435444
171ribosomal small subunit biogenesis (GO:0042274)2.17386572
172establishment of viral latency (GO:0019043)2.17236528
173positive regulation of nuclease activity (GO:0032075)2.15720620
174regulation of metalloenzyme activity (GO:0048552)2.15215072
175regulation of translational termination (GO:0006449)2.15051220
176negative regulation of ligase activity (GO:0051352)2.14912423
177negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.14912423
178regulation of viral release from host cell (GO:1902186)2.14173084
179* nucleotide-sugar biosynthetic process (GO:0009226)2.13789370
180T cell apoptotic process (GO:0070231)2.12395994
181positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.12278483
182cellular response to interleukin-4 (GO:0071353)2.11752425
183establishment of integrated proviral latency (GO:0075713)2.10641203
184DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.08739877
185regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.07093315
186regulation of necrotic cell death (GO:0010939)2.06822296
187signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.06622854
188intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.06622854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.58673267
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33774379
3E2F7_22180533_ChIP-Seq_HELA_Human3.29613506
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.93065841
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71681292
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67643998
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58743225
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.52697032
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52016284
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30902270
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24742803
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22133887
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22133887
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22133887
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21339265
16ZNF263_19887448_ChIP-Seq_K562_Human2.15424078
17VDR_21846776_ChIP-Seq_THP-1_Human2.12905281
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.11869701
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.04350889
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99625990
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99274467
22KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96005225
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93872333
24* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91706439
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91249991
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.86321977
27* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82503968
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.81959365
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80492424
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.77964859
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.77233352
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76470765
33DCP1A_22483619_ChIP-Seq_HELA_Human1.75261320
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74743299
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73156234
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72907161
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72425480
38GABP_19822575_ChIP-Seq_HepG2_Human1.70930173
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69726660
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68203801
41NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66542547
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.65138657
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63908377
44XRN2_22483619_ChIP-Seq_HELA_Human1.63752479
45PU.1_20513432_ChIP-Seq_Bcells_Mouse1.60817046
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59569805
47MYC_22102868_ChIP-Seq_BL_Human1.59366804
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58155751
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57145847
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55796983
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54858733
52* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54792555
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51747862
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49122970
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48923256
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47938534
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46621106
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41101631
59LXR_22292898_ChIP-Seq_THP-1_Human1.41087765
60* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40977950
61VDR_23849224_ChIP-Seq_CD4+_Human1.40588136
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39736993
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39044762
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38602715
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.37989623
66TTF2_22483619_ChIP-Seq_HELA_Human1.37640098
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36636264
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35031632
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34999967
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34706480
71* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34653893
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.34339686
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34050596
74P68_20966046_ChIP-Seq_HELA_Human1.34026167
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33976999
76KDM5A_27292631_Chip-Seq_BREAST_Human1.33764908
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33502472
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32869774
79* TET1_21451524_ChIP-Seq_MESCs_Mouse1.32867044
80ATF3_27146783_Chip-Seq_COLON_Human1.31518110
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30285227
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30026606
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28907276
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27563971
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26951920
86TCF7_22412390_ChIP-Seq_EML_Mouse1.25974696
87PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22827058
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22574354
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21161596
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20920742
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20777766
92* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20451052
93MAF_26560356_Chip-Seq_TH1_Human1.20398905
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.19852920
95* ELF1_20517297_ChIP-Seq_JURKAT_Human1.18211642
96* BCOR_27268052_Chip-Seq_Bcells_Human1.16885332
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16784266
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16519851
99VDR_24763502_ChIP-Seq_THP-1_Human1.16409290
100* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15960234
101POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15674838
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.15525253
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15121105
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14987513
105* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14968098
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14810952
107TFEB_21752829_ChIP-Seq_HELA_Human1.14714199
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14171721
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13847989
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13822870
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13668171
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12842884
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12203777
114* BCL6_27268052_Chip-Seq_Bcells_Human1.12131462
115NCOR1_26117541_ChIP-Seq_K562_Human1.11312187
116KDM2B_26808549_Chip-Seq_DND41_Human1.10985009
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10738536
118MAF_26560356_Chip-Seq_TH2_Human1.10738533
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10420209
120RXR_22158963_ChIP-Seq_LIVER_Mouse1.09441794
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09175743
122ETS1_21867929_ChIP-Seq_TH2_Mouse1.08691521
123FOXP3_21729870_ChIP-Seq_TREG_Human1.08510716
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08409703
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07930393
126RUNX1_22412390_ChIP-Seq_EML_Mouse1.07916015
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06790067
128RACK7_27058665_Chip-Seq_MCF-7_Human1.06139386
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05122128
130* UTX_26944678_Chip-Seq_JUKART_Human1.04940230
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03423174
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03110896
133RARB_24833708_ChIP-Seq_LIVER_Mouse1.02772464
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02452362
135ESR2_21235772_ChIP-Seq_MCF-7_Human1.01960421
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01308716
137RARA_24833708_ChIP-Seq_LIVER_Mouse1.00832441
138CTCF_26484167_Chip-Seq_Bcells_Mouse1.00225525
139CLOCK_20551151_ChIP-Seq_293T_Human1.00056533
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98412410
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98353568
142* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98113273
143* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98037882
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97708629
145SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97329469
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96743300
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95469385
148PHF8_20622854_ChIP-Seq_HELA_Human0.94938519
149HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94779759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.72705205
2MP0009278_abnormal_bone_marrow3.68081895
3MP0005171_absent_coat_pigmentation3.67759586
4MP0010234_abnormal_vibrissa_follicle3.40774914
5MP0010030_abnormal_orbit_morphology3.17171454
6MP0004233_abnormal_muscle_weight2.98203505
7MP0010094_abnormal_chromosome_stability2.92444268
8MP0004957_abnormal_blastocyst_morpholog2.91191582
9MP0005451_abnormal_body_composition2.77993789
10MP0003705_abnormal_hypodermis_morpholog2.72708807
11MP0005083_abnormal_biliary_tract2.65587010
12MP0008260_abnormal_autophagy2.58753156
13MP0003693_abnormal_embryo_hatching2.57310632
14MP0002009_preneoplasia2.53693620
15MP0005174_abnormal_tail_pigmentation2.32077790
16MP0003191_abnormal_cellular_cholesterol2.29780418
17MP0001545_abnormal_hematopoietic_system2.29260606
18MP0005397_hematopoietic_system_phenotyp2.29260606
19MP0003890_abnormal_embryonic-extraembry2.24924472
20MP0003786_premature_aging2.24678065
21MP0008058_abnormal_DNA_repair2.22777947
22MP0003111_abnormal_nucleus_morphology2.14313272
23MP0003566_abnormal_cell_adhesion2.11428463
24MP0009840_abnormal_foam_cell2.02157752
25MP0001849_ear_inflammation2.00688820
26MP0008995_early_reproductive_senescence1.99978528
27MP0003077_abnormal_cell_cycle1.98227135
28MP0005360_urolithiasis1.96642621
29MP0010352_gastrointestinal_tract_polyps1.95517163
30MP0004133_heterotaxia1.93953654
31MP0003436_decreased_susceptibility_to1.92725077
32MP0008932_abnormal_embryonic_tissue1.87024749
33MP0005075_abnormal_melanosome_morpholog1.82326026
34MP0000858_altered_metastatic_potential1.71151011
35MP0003283_abnormal_digestive_organ1.68647213
36MP0002877_abnormal_melanocyte_morpholog1.66536976
37MP0003119_abnormal_digestive_system1.65451212
38MP0004947_skin_inflammation1.64341356
39MP0003806_abnormal_nucleotide_metabolis1.62100645
40MP0002653_abnormal_ependyma_morphology1.57028742
41MP0001697_abnormal_embryo_size1.55250615
42MP0004147_increased_porphyrin_level1.55026356
43MP0000015_abnormal_ear_pigmentation1.54772145
44MP0005058_abnormal_lysosome_morphology1.54610015
45* MP0000490_abnormal_crypts_of1.53839636
46MP0002086_abnormal_extraembryonic_tissu1.52338552
47MP0000678_abnormal_parathyroid_gland1.52004172
48MP0000371_diluted_coat_color1.49603797
49MP0003453_abnormal_keratinocyte_physiol1.49236194
50MP0001293_anophthalmia1.47884484
51MP0001216_abnormal_epidermal_layer1.47211323
52MP0008877_abnormal_DNA_methylation1.46196217
53MP0003172_abnormal_lysosome_physiology1.43549898
54MP0003718_maternal_effect1.42515756
55MP0000470_abnormal_stomach_morphology1.39564648
56MP0000685_abnormal_immune_system1.37991961
57MP0005076_abnormal_cell_differentiation1.36552589
58* MP0010155_abnormal_intestine_physiology1.34963212
59MP0002282_abnormal_trachea_morphology1.34383476
60MP0002019_abnormal_tumor_incidence1.33790814
61MP0004185_abnormal_adipocyte_glucose1.32359864
62MP0004858_abnormal_nervous_system1.31638661
63MP0002084_abnormal_developmental_patter1.31035047
64MP0005085_abnormal_gallbladder_physiolo1.30963758
65MP0004264_abnormal_extraembryonic_tissu1.30649812
66MP0000350_abnormal_cell_proliferation1.29166093
67MP0005464_abnormal_platelet_physiology1.28704268
68MP0002249_abnormal_larynx_morphology1.28200798
69MP0001881_abnormal_mammary_gland1.28079999
70MP0001730_embryonic_growth_arrest1.25585521
71MP0002085_abnormal_embryonic_tissue1.25519388
72MP0009931_abnormal_skin_appearance1.24403634
73MP0000467_abnormal_esophagus_morphology1.23450884
74MP0005365_abnormal_bile_salt1.23180217
75MP0003567_abnormal_fetal_cardiomyocyte1.22176493
76MP0005380_embryogenesis_phenotype1.22117402
77MP0001672_abnormal_embryogenesis/_devel1.22117402
78MP0004197_abnormal_fetal_growth/weight/1.21570219
79MP0006072_abnormal_retinal_apoptosis1.18576289
80MP0002254_reproductive_system_inflammat1.15133155
81MP0002269_muscular_atrophy1.14709159
82MP0003656_abnormal_erythrocyte_physiolo1.14677951
83MP0005025_abnormal_response_to1.14673550
84MP0009333_abnormal_splenocyte_physiolog1.14441678
85MP0004782_abnormal_surfactant_physiolog1.13428898
86MP0001853_heart_inflammation1.09780117
87MP0008438_abnormal_cutaneous_collagen1.09340110
88* MP0002080_prenatal_lethality1.08469433
89MP0002405_respiratory_system_inflammati1.07551540
90MP0000313_abnormal_cell_death1.05694158
91MP0002396_abnormal_hematopoietic_system1.03109574
92MP0002166_altered_tumor_susceptibility1.01493336
93MP0005266_abnormal_metabolism1.00847033
94MP0001243_abnormal_dermal_layer0.99998815
95MP0002132_abnormal_respiratory_system0.98232081
96MP0002098_abnormal_vibrissa_morphology0.97246833
97MP0003300_gastrointestinal_ulcer0.96864069
98MP0000462_abnormal_digestive_system0.96041297
99MP0000689_abnormal_spleen_morphology0.95974280
100MP0002111_abnormal_tail_morphology0.94641029
101MP0003984_embryonic_growth_retardation0.94583493
102MP0010771_integument_phenotype0.94413292
103MP0001873_stomach_inflammation0.93992816
104MP0002139_abnormal_hepatobiliary_system0.93636808
105MP0009785_altered_susceptibility_to0.92751869
106MP0010307_abnormal_tumor_latency0.91870996
107MP0002075_abnormal_coat/hair_pigmentati0.91440463
108MP0008007_abnormal_cellular_replicative0.90635717
109MP0002088_abnormal_embryonic_growth/wei0.89930135
110MP0004381_abnormal_hair_follicle0.89235928
111MP0005023_abnormal_wound_healing0.89104135
112MP0000609_abnormal_liver_physiology0.88802361
113MP0001764_abnormal_homeostasis0.88487772
114MP0003763_abnormal_thymus_physiology0.88080952
115MP0000639_abnormal_adrenal_gland0.88017145
116MP0003186_abnormal_redox_activity0.87907563
117MP0000465_gastrointestinal_hemorrhage0.86699472
118MP0001661_extended_life_span0.86215514
119MP0000377_abnormal_hair_follicle0.84749588
120MP0001186_pigmentation_phenotype0.84653464
121MP0000627_abnormal_mammary_gland0.84362114
122MP0006082_CNS_inflammation0.84150363
123MP0001533_abnormal_skeleton_physiology0.83029961
124MP0005319_abnormal_enzyme/_coenzyme0.82793673
125MP0001835_abnormal_antigen_presentation0.82273413
126MP0002419_abnormal_innate_immunity0.82169792
127MP0001666_abnormal_nutrient_absorption0.81790066
128MP0005621_abnormal_cell_physiology0.81567850
129MP0000537_abnormal_urethra_morphology0.81469973
130MP0002796_impaired_skin_barrier0.81439740
131MP0002148_abnormal_hypersensitivity_rea0.79409143
132MP0009643_abnormal_urine_homeostasis0.78855718
133* MP0002429_abnormal_blood_cell0.78808941
134MP0003315_abnormal_perineum_morphology0.78469790
135MP0005000_abnormal_immune_tolerance0.78256674
136MP0006035_abnormal_mitochondrial_morpho0.78202939
137* MP0003866_abnormal_defecation0.76765826
138MP0002932_abnormal_joint_morphology0.76439391
139MP0003303_peritoneal_inflammation0.76070471
140MP0005220_abnormal_exocrine_pancreas0.75969737
141MP0002089_abnormal_postnatal_growth/wei0.75791485
142* MP0001845_abnormal_inflammatory_respons0.75503501
143MP0002006_tumorigenesis0.75256545
144MP0000003_abnormal_adipose_tissue0.75165192
145MP0000579_abnormal_nail_morphology0.74771383
146MP0001145_abnormal_male_reproductive0.74135888
147MP0002722_abnormal_immune_system0.73745723
148MP0002060_abnormal_skin_morphology0.73319629
149MP0005501_abnormal_skin_physiology0.73070334
150MP0009115_abnormal_fat_cell0.73042529
151MP0001324_abnormal_eye_pigmentation0.72299400
152* MP0000477_abnormal_intestine_morphology0.70126130
153MP0006036_abnormal_mitochondrial_physio0.69381384
154MP0003943_abnormal_hepatobiliary_system0.67060087
155MP0009053_abnormal_anal_canal0.65881823
156* MP0002398_abnormal_bone_marrow0.63235035
157MP0004019_abnormal_vitamin_homeostasis0.62943510
158MP0000358_abnormal_cell_content/0.60985860
159MP0005376_homeostasis/metabolism_phenot0.60477965

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.30801955
2Increased IgM level (HP:0003496)4.99817788
3Poikiloderma (HP:0001029)4.74145589
4Rib fusion (HP:0000902)4.66140887
5Rectovaginal fistula (HP:0000143)4.49873845
6Rectal fistula (HP:0100590)4.49873845
7Facial hemangioma (HP:0000329)4.33079049
8Alopecia of scalp (HP:0002293)4.26176764
9Concave nail (HP:0001598)4.23600596
10Annular pancreas (HP:0001734)4.16945205
11Tongue fasciculations (HP:0001308)4.04556195
12Vaginal fistula (HP:0004320)4.02315574
13Intestinal fistula (HP:0100819)3.98635012
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.97980053
15Abnormal hemoglobin (HP:0011902)3.74144407
16Cholecystitis (HP:0001082)3.65464760
17Abnormal gallbladder physiology (HP:0012438)3.65464760
18Muscle fibrillation (HP:0010546)3.63881307
19Hypochromic microcytic anemia (HP:0004840)3.59050975
20Male infertility (HP:0003251)3.47456462
21Ulnar bowing (HP:0003031)3.42779617
22Turricephaly (HP:0000262)3.42163573
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.35577246
24Vertebral hypoplasia (HP:0008417)3.35577246
25Aplasia/hypoplasia of the humerus (HP:0006507)3.32690955
26Orthostatic hypotension (HP:0001278)3.29349223
27Short humerus (HP:0005792)3.29345113
28Absent thumb (HP:0009777)3.22758319
29Selective tooth agenesis (HP:0001592)3.17822581
30Albinism (HP:0001022)3.17481098
31Intestinal atresia (HP:0011100)3.16424110
32Mucopolysacchariduria (HP:0008155)3.11621705
33Urinary glycosaminoglycan excretion (HP:0003541)3.11621705
34Abnormality of the heme biosynthetic pathway (HP:0010472)3.11294510
35Absent radius (HP:0003974)3.09802428
36Vertebral compression fractures (HP:0002953)3.06202823
37Abnormality of male internal genitalia (HP:0000022)3.05798249
38Squamous cell carcinoma (HP:0002860)3.03637305
39Premature graying of hair (HP:0002216)2.92448528
40Patellar aplasia (HP:0006443)2.89094747
41Cholelithiasis (HP:0001081)2.88879703
42Absent forearm bone (HP:0003953)2.87289810
43Aplasia involving forearm bones (HP:0009822)2.87289810
44Congenital hip dislocation (HP:0001374)2.85898959
45Joint stiffness (HP:0001387)2.84174399
46Dysautonomia (HP:0002459)2.80926851
47Basal cell carcinoma (HP:0002671)2.80388492
48Reticulocytosis (HP:0001923)2.80199230
49Rough bone trabeculation (HP:0100670)2.78907874
50Distal lower limb muscle weakness (HP:0009053)2.77106978
51Diaphragmatic weakness (HP:0009113)2.76550891
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71934274
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71934274
54Abnormality of polysaccharide metabolism (HP:0011012)2.71934274
55Broad alveolar ridges (HP:0000187)2.69067887
56Dysostosis multiplex (HP:0000943)2.68628635
57Coronal craniosynostosis (HP:0004440)2.68193615
58Aplasia/Hypoplasia of the patella (HP:0006498)2.66390293
59Bifid uvula (HP:0000193)2.65507160
60Testicular atrophy (HP:0000029)2.64111826
61Muscle fiber atrophy (HP:0100295)2.62699396
62Abnormality of the aortic arch (HP:0012303)2.61092634
63Premature skin wrinkling (HP:0100678)2.60862472
64Short chin (HP:0000331)2.58502919
65Large for gestational age (HP:0001520)2.58137722
66Pancreatic islet-cell hyperplasia (HP:0004510)2.56715618
67Pili torti (HP:0003777)2.56064133
68Hypochromic anemia (HP:0001931)2.55183184
69Premature rupture of membranes (HP:0001788)2.54806104
70Type 2 muscle fiber atrophy (HP:0003554)2.54044392
71Exertional dyspnea (HP:0002875)2.53914214
72IgA deficiency (HP:0002720)2.53616094
73Growth hormone excess (HP:0000845)2.52923628
74Trismus (HP:0000211)2.50741575
75Abnormal hair laboratory examination (HP:0003328)2.49340046
76Hypokinesia (HP:0002375)2.48424039
77Abnormal gallbladder morphology (HP:0012437)2.47592429
78Ragged-red muscle fibers (HP:0003200)2.41357295
79Increased connective tissue (HP:0009025)2.41281420
80Redundant skin (HP:0001582)2.37931648
81Distal upper limb amyotrophy (HP:0007149)2.37908336
82Upper limb amyotrophy (HP:0009129)2.37908336
83Increased serum ferritin (HP:0003281)2.31732828
84Abnormality of the distal phalanges of the toes (HP:0010182)2.30873275
85Flat acetabular roof (HP:0003180)2.30515834
86Capillary hemangiomas (HP:0005306)2.29902079
87Hypertensive crisis (HP:0100735)2.28223439
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.28182236
89Achilles tendon contracture (HP:0001771)2.25908424
90Alacrima (HP:0000522)2.25232871
91Anteriorly placed anus (HP:0001545)2.24686927
92Hypoplasia of the radius (HP:0002984)2.24362767
93Ileus (HP:0002595)2.23912706
94Distal lower limb amyotrophy (HP:0008944)2.21755039
95Polycythemia (HP:0001901)2.20898446
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19519697
97Breast hypoplasia (HP:0003187)2.19331782
98Abnormal trabecular bone morphology (HP:0100671)2.17580319
99Cervical subluxation (HP:0003308)2.17076826
100Gastrointestinal dysmotility (HP:0002579)2.16229223
101Nonimmune hydrops fetalis (HP:0001790)2.10595705
102Abnormality of the Achilles tendon (HP:0005109)2.10508850
103Abnormality of the gallbladder (HP:0005264)2.10357034
104Abnormal number of erythroid precursors (HP:0012131)2.10241446
105Malnutrition (HP:0004395)2.10053800
106Petechiae (HP:0000967)2.08764617
107Short nail (HP:0001799)2.07207900
108Cheilitis (HP:0100825)2.07136187
109Hypotrichosis (HP:0001006)2.07037895
110Aplasia of the musculature (HP:0100854)2.06930856
111Abnormality of the anterior horn cell (HP:0006802)2.06687109
112Degeneration of anterior horn cells (HP:0002398)2.06687109
113Hepatosplenomegaly (HP:0001433)2.06606592
114Hamartoma (HP:0010566)2.06083946
115Thin bony cortex (HP:0002753)2.05735996
116Abnormality of cells of the erythroid lineage (HP:0012130)2.05708004
117Progressive muscle weakness (HP:0003323)2.04589951
118Nail dystrophy (HP:0008404)2.03725407
119Centrally nucleated skeletal muscle fibers (HP:0003687)2.03682217
120Hypotelorism (HP:0000601)2.03340017
121Abnormality of the umbilical cord (HP:0010881)2.02972591
122Abnormality of reticulocytes (HP:0004312)2.02552828
123Fragile skin (HP:0001030)2.02449292
124Myopathic facies (HP:0002058)2.02385357
125Abnormal blistering of the skin (HP:0008066)2.00657958
126Abnormality of placental membranes (HP:0011409)1.99939919
127Amniotic constriction ring (HP:0009775)1.99939919
128Hemorrhage of the eye (HP:0011885)1.99358346
129J-shaped sella turcica (HP:0002680)1.98994494
130Bowing of the arm (HP:0006488)1.98847604
131Bowed forearm bones (HP:0003956)1.98847604
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.98634633
133Amelogenesis imperfecta (HP:0000705)1.96703735
134Abnormality of nail color (HP:0100643)1.96679388
135Choanal stenosis (HP:0000452)1.96529787
136Acute lymphatic leukemia (HP:0006721)1.96392909
137Abnormal number of incisors (HP:0011064)1.95880280
138Short 5th finger (HP:0009237)1.95526343
139Abnormality of the ileum (HP:0001549)1.95213822
140Eczematoid dermatitis (HP:0000976)1.95113542
141Seborrheic dermatitis (HP:0001051)1.95082346
142Lower limb hyperreflexia (HP:0002395)1.93800315
143Deep venous thrombosis (HP:0002625)1.93303102
144Generalized amyotrophy (HP:0003700)1.93006375
145Bulbar palsy (HP:0001283)1.92762771
146Congenital ichthyosiform erythroderma (HP:0007431)1.91476085
147Stridor (HP:0010307)1.89521870
148Hypobetalipoproteinemia (HP:0003563)1.89437408
149Sparse eyelashes (HP:0000653)1.88653579
150Increased cerebral lipofuscin (HP:0011813)1.88528041
151Long palpebral fissure (HP:0000637)1.88115514
152Hypertriglyceridemia (HP:0002155)1.87240187
153Flattened epiphyses (HP:0003071)1.87228172
154Opisthotonus (HP:0002179)1.87050364
155Hyperbilirubinemia (HP:0002904)1.85784971
156Abnormality of iron homeostasis (HP:0011031)1.85508525
157Onycholysis (HP:0001806)1.84554318
158Popliteal pterygium (HP:0009756)1.84119744
159Osteolytic defects of the hand bones (HP:0009699)1.81493691
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.81493691
161Fragile nails (HP:0001808)1.81490819
162Median cleft lip (HP:0000161)1.81488977
163Increased IgE level (HP:0003212)1.81060998
164Clumsiness (HP:0002312)1.79333302
165Spinal muscular atrophy (HP:0007269)1.79310536
166Microvesicular hepatic steatosis (HP:0001414)1.78678435
167Hand muscle atrophy (HP:0009130)1.78574349
168Hyperacusis (HP:0010780)1.77455372
169Cerebral palsy (HP:0100021)1.75662756
170Abnormality of pyrimidine metabolism (HP:0004353)1.72822192
171Abdominal distention (HP:0003270)1.72116050
172Right ventricular cardiomyopathy (HP:0011663)1.71779265
173Abnormalities of placenta or umbilical cord (HP:0001194)1.71763904
174Broad face (HP:0000283)1.71209901
175Hyperparathyroidism (HP:0000843)1.70710737
176Villous atrophy (HP:0011473)1.68480162
177Abnormality of small intestinal villus morphology (HP:0011472)1.68480162
178Elbow flexion contracture (HP:0002987)1.68087888
179Abnormal enzyme/coenzyme activity (HP:0012379)1.67891339
180Axonal loss (HP:0003447)1.66972850
181Abnormality of glutamine family amino acid metabolism (HP:0010902)1.66401099
182Hyperammonemia (HP:0001987)1.66150194
183Polygenic inheritance (HP:0010982)1.66142170
184Bone pain (HP:0002653)1.66056919
185Atrophic scars (HP:0001075)1.65905873
186Abnormality of alkaline phosphatase activity (HP:0004379)1.65432301
187Ridged nail (HP:0001807)1.64566530
188Urticaria (HP:0001025)1.63526976
189Systemic lupus erythematosus (HP:0002725)1.63297314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.33687382
2DDR24.49807250
3MAPK154.48777202
4MAP3K64.05772908
5MAP3K113.76564243
6PIM23.14164820
7PINK13.07033232
8MST1R3.05782037
9SMG12.96396027
10MATK2.90650243
11DAPK12.65777021
12IRAK32.62696143
13SIK12.51676369
14FGR2.24490196
15TYRO32.16299740
16VRK22.14870443
17CDK72.12066336
18YES12.09006192
19BMX2.04744538
20CSK2.00895185
21BUB11.95597490
22PRPF4B1.93401308
23DYRK1B1.85180565
24UHMK11.81510691
25PRKD21.77015346
26PKN21.75374867
27AKT31.75110600
28PIM11.69527611
29PDGFRA1.64729522
30MAP3K31.51087813
31MAP2K31.47702352
32RPS6KL11.42535198
33RPS6KC11.42535198
34TRPM71.41811849
35ARAF1.40742390
36TAOK11.40451515
37MET1.35905931
38SIK31.34134792
39GRK61.34045447
40SCYL21.29977620
41RPS6KA61.29261763
42PTK61.27392450
43RIPK11.26159789
44NME21.25440024
45CDK61.20550741
46LRRK21.20505514
47PLK11.16291707
48DYRK31.15356917
49BCKDK1.15324082
50EPHB11.14809174
51TBK11.14177671
52WEE11.08071881
53MAPK111.07461226
54CHEK21.06476567
55LMTK21.05485981
56EEF2K1.02234928
57ILK1.01602198
58PTK20.98697274
59FGFR40.98376521
60RPS6KB20.97939489
61PBK0.95958372
62EPHA20.95623165
63LATS20.94713087
64TESK20.91943138
65ATR0.88865842
66MAP2K20.85563788
67MAP3K100.85241745
68LIMK10.85121162
69CDC42BPA0.81908093
70GSK3A0.81353531
71MAP3K120.76640499
72ABL20.76168078
73MAP3K10.76116733
74EIF2AK10.75577753
75BRAF0.74322034
76RPS6KA10.72410567
77TAOK20.71575415
78IRAK40.71495801
79AURKA0.68799573
80CSNK2A10.67729514
81FLT30.65779717
82AURKB0.65007403
83TTN0.64247599
84CDC70.64135437
85NEK20.63334201
86MAPKAPK30.62031097
87RAF10.59955929
88MAP4K10.57191830
89BRSK20.56668402
90LYN0.56044688
91JAK30.55014900
92TRIB30.54827103
93PAK40.54195544
94RPS6KB10.53752457
95NEK10.53116724
96STK38L0.52983081
97MTOR0.51996081
98ERBB30.50866333
99PDPK10.50332348
100PHKG10.49754302
101PHKG20.49754302
102ACVR1B0.49331212
103TYK20.48596766
104CDK20.47424342
105CSNK2A20.46921919
106PRKAA10.46328959
107MAP3K140.46184681
108MUSK0.44776735
109HIPK20.43717968
110CDK80.43126694
111STK160.42320649
112MAPKAPK20.41372403
113TESK10.40690853
114ERN10.40587875
115PDK20.38765689
116IKBKB0.38736320
117TLK10.38497141
118MYLK0.37845695
119PAK10.36763929
120RPS6KA20.36706204
121MST40.36548253
122MAPK30.36298356
123CDK40.35870136
124RIPK40.35866040
125ZAP700.34900214
126SRPK10.34685145
127BRSK10.34570994
128RPS6KA40.34418048
129EGFR0.34390798
130PRKCI0.34085938
131IRAK20.34057029
132MAPK40.33792749
133AKT20.33346688
134MAP3K80.32744805
135CDK90.32116863
136CHEK10.30872529
137EIF2AK30.30862082
138NME10.30810702
139ATM0.30740075
140CLK10.30419014
141DYRK20.29879971
142TNK20.28941393
143IKBKE0.28940865
144STK40.27793698
145TTK0.26442040
146STK100.26292438
147MAPK10.26182538
148KDR0.25882672
149CAMK2G0.24355796
150CHUK0.24077696
151PRKCD0.24004467
152PRKG20.23540573

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.03564781
2Base excision repair_Homo sapiens_hsa034104.66918021
3DNA replication_Homo sapiens_hsa030304.54409257
4Fatty acid biosynthesis_Homo sapiens_hsa000613.63190608
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68442215
6Nucleotide excision repair_Homo sapiens_hsa034202.65996029
7Ribosome_Homo sapiens_hsa030102.59312282
8Spliceosome_Homo sapiens_hsa030402.47659560
9Proteasome_Homo sapiens_hsa030502.41094372
10RNA transport_Homo sapiens_hsa030132.33631047
11Homologous recombination_Homo sapiens_hsa034402.30663345
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18378438
13Other glycan degradation_Homo sapiens_hsa005112.13837958
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04045561
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84761842
16Sulfur relay system_Homo sapiens_hsa041221.83886942
17Folate biosynthesis_Homo sapiens_hsa007901.78709193
18Fanconi anemia pathway_Homo sapiens_hsa034601.76843540
19Biosynthesis of amino acids_Homo sapiens_hsa012301.74918169
20Arginine and proline metabolism_Homo sapiens_hsa003301.70911052
21mRNA surveillance pathway_Homo sapiens_hsa030151.59286540
22RNA polymerase_Homo sapiens_hsa030201.51197961
23p53 signaling pathway_Homo sapiens_hsa041151.50102215
24Cell cycle_Homo sapiens_hsa041101.48489780
25Phenylalanine metabolism_Homo sapiens_hsa003601.47677081
26Pyrimidine metabolism_Homo sapiens_hsa002401.38726601
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37547850
28* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37188729
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29548298
30One carbon pool by folate_Homo sapiens_hsa006701.29237270
31Notch signaling pathway_Homo sapiens_hsa043301.28280737
32Sulfur metabolism_Homo sapiens_hsa009201.23243407
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.20761679
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13157070
35Galactose metabolism_Homo sapiens_hsa000521.11482744
36mTOR signaling pathway_Homo sapiens_hsa041501.08207969
37Circadian rhythm_Homo sapiens_hsa047101.07988320
38Hippo signaling pathway_Homo sapiens_hsa043901.06206969
39Shigellosis_Homo sapiens_hsa051311.05593542
40Bladder cancer_Homo sapiens_hsa052191.05148987
41Legionellosis_Homo sapiens_hsa051341.02562100
42Vibrio cholerae infection_Homo sapiens_hsa051101.01707012
43Glutathione metabolism_Homo sapiens_hsa004801.01511133
44Primary immunodeficiency_Homo sapiens_hsa053401.01345543
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99856289
46Fatty acid elongation_Homo sapiens_hsa000620.97466224
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95399278
48Hedgehog signaling pathway_Homo sapiens_hsa043400.92541424
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.92080515
50Fatty acid metabolism_Homo sapiens_hsa012120.90687504
51RNA degradation_Homo sapiens_hsa030180.90439834
52Pancreatic cancer_Homo sapiens_hsa052120.89080494
53Hepatitis C_Homo sapiens_hsa051600.88897559
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88160767
55Adherens junction_Homo sapiens_hsa045200.79992814
56Tyrosine metabolism_Homo sapiens_hsa003500.79396356
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77655237
58TGF-beta signaling pathway_Homo sapiens_hsa043500.77385469
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.77016905
60Lysosome_Homo sapiens_hsa041420.73516194
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71994364
62N-Glycan biosynthesis_Homo sapiens_hsa005100.71884267
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.71833785
64Basal transcription factors_Homo sapiens_hsa030220.68644354
65Selenocompound metabolism_Homo sapiens_hsa004500.67568268
66Prion diseases_Homo sapiens_hsa050200.67511173
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.66132998
68Non-homologous end-joining_Homo sapiens_hsa034500.65523509
69Epstein-Barr virus infection_Homo sapiens_hsa051690.64633741
70Non-small cell lung cancer_Homo sapiens_hsa052230.63331207
71Salmonella infection_Homo sapiens_hsa051320.62953278
72Arginine biosynthesis_Homo sapiens_hsa002200.62863807
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62263391
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61929735
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.61428570
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.59690557
77Viral carcinogenesis_Homo sapiens_hsa052030.58423393
78Thyroid cancer_Homo sapiens_hsa052160.58320700
79Herpes simplex infection_Homo sapiens_hsa051680.58292924
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58278308
81Endocytosis_Homo sapiens_hsa041440.58084772
82Influenza A_Homo sapiens_hsa051640.54766464
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54311509
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54237418
85Pentose phosphate pathway_Homo sapiens_hsa000300.52979411
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52088058
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51333439
88Carbon metabolism_Homo sapiens_hsa012000.50207424
89Oocyte meiosis_Homo sapiens_hsa041140.49790551
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48934667
91Huntingtons disease_Homo sapiens_hsa050160.48565538
92Lysine degradation_Homo sapiens_hsa003100.47573519
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47387205
94Malaria_Homo sapiens_hsa051440.47212305
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46731604
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45642934
97Vitamin B6 metabolism_Homo sapiens_hsa007500.45513701
98Fat digestion and absorption_Homo sapiens_hsa049750.43879161
99Viral myocarditis_Homo sapiens_hsa054160.43482765
100Parkinsons disease_Homo sapiens_hsa050120.42775123
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.42590795
102Basal cell carcinoma_Homo sapiens_hsa052170.42218816
103Vitamin digestion and absorption_Homo sapiens_hsa049770.40993314
104Acute myeloid leukemia_Homo sapiens_hsa052210.40687780
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38321534
106Insulin signaling pathway_Homo sapiens_hsa049100.37365684
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37059419
108Purine metabolism_Homo sapiens_hsa002300.35940199
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35806104
110Antigen processing and presentation_Homo sapiens_hsa046120.35799846
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.35460903
112Caffeine metabolism_Homo sapiens_hsa002320.35413402
113Small cell lung cancer_Homo sapiens_hsa052220.35378623
114VEGF signaling pathway_Homo sapiens_hsa043700.33878599
115TNF signaling pathway_Homo sapiens_hsa046680.33871513
116Toxoplasmosis_Homo sapiens_hsa051450.33861276
117Colorectal cancer_Homo sapiens_hsa052100.31647961
118Oxidative phosphorylation_Homo sapiens_hsa001900.31497628
119Wnt signaling pathway_Homo sapiens_hsa043100.30937751
120* Metabolic pathways_Homo sapiens_hsa011000.30474886
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30010165
122Pyruvate metabolism_Homo sapiens_hsa006200.29353661
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28375399
124Pertussis_Homo sapiens_hsa051330.27384512
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26780448
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26670415
127MicroRNAs in cancer_Homo sapiens_hsa052060.25454317
128Chronic myeloid leukemia_Homo sapiens_hsa052200.25100363
129Apoptosis_Homo sapiens_hsa042100.24817253
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24389707
131Measles_Homo sapiens_hsa051620.24335944
132HTLV-I infection_Homo sapiens_hsa051660.22524218
133* Fructose and mannose metabolism_Homo sapiens_hsa000510.21433436
134Tight junction_Homo sapiens_hsa045300.20774647
135Hepatitis B_Homo sapiens_hsa051610.19209357
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19171187
137Renin-angiotensin system_Homo sapiens_hsa046140.17976643

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