TSTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)6.89566060
2sulfur amino acid catabolic process (GO:0000098)6.75635790
3ketone body metabolic process (GO:1902224)5.98765612
4bile acid and bile salt transport (GO:0015721)5.95403102
5flavonoid metabolic process (GO:0009812)5.78265908
6cellular glucuronidation (GO:0052695)5.53658025
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.50443412
8L-phenylalanine catabolic process (GO:0006559)5.50443412
9ATP synthesis coupled proton transport (GO:0015986)5.45072119
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.45072119
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30712056
12L-phenylalanine metabolic process (GO:0006558)5.30712056
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.11746044
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11332414
15aromatic amino acid family catabolic process (GO:0009074)5.00977168
16uronic acid metabolic process (GO:0006063)4.97284189
17glucuronate metabolic process (GO:0019585)4.97284189
18respiratory electron transport chain (GO:0022904)4.92004934
19protein complex biogenesis (GO:0070271)4.90851774
20electron transport chain (GO:0022900)4.88833787
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.75869481
223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.75869481
23negative regulation of sterol transport (GO:0032372)4.70447017
24negative regulation of cholesterol transport (GO:0032375)4.70447017
25high-density lipoprotein particle remodeling (GO:0034375)4.64741996
26DNA deamination (GO:0045006)4.62683346
27indole-containing compound catabolic process (GO:0042436)4.59926767
28indolalkylamine catabolic process (GO:0046218)4.59926767
29tryptophan catabolic process (GO:0006569)4.59926767
30ribosomal small subunit assembly (GO:0000028)4.59479160
31regulation of cholesterol esterification (GO:0010872)4.58143171
32phospholipid efflux (GO:0033700)4.57419305
33mitochondrial respiratory chain complex assembly (GO:0033108)4.51656316
34cytochrome complex assembly (GO:0017004)4.50897705
35pyrimidine-containing compound transmembrane transport (GO:0072531)4.47921652
36cytidine metabolic process (GO:0046087)4.42708651
37cytidine catabolic process (GO:0006216)4.42708651
38cytidine deamination (GO:0009972)4.42708651
39kynurenine metabolic process (GO:0070189)4.42577624
40alkaloid metabolic process (GO:0009820)4.39866697
41respiratory chain complex IV assembly (GO:0008535)4.34851303
42bile acid biosynthetic process (GO:0006699)4.25920966
43cysteine metabolic process (GO:0006534)4.25764539
44drug catabolic process (GO:0042737)4.24259464
45tryptophan metabolic process (GO:0006568)4.21959986
46glyoxylate metabolic process (GO:0046487)4.20549593
47viral transcription (GO:0019083)4.20466327
48complement activation, alternative pathway (GO:0006957)4.19237819
49establishment of protein localization to mitochondrial membrane (GO:0090151)4.15533027
50negative regulation of fibrinolysis (GO:0051918)4.14355941
51serine family amino acid catabolic process (GO:0009071)4.11296391
52urea cycle (GO:0000050)4.10002105
53urea metabolic process (GO:0019627)4.10002105
54homocysteine metabolic process (GO:0050667)4.09587282
55translational termination (GO:0006415)4.07028613
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02512804
57mitochondrial respiratory chain complex I assembly (GO:0032981)4.02512804
58NADH dehydrogenase complex assembly (GO:0010257)4.02512804
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.01883300
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.01883300
61regulation of triglyceride catabolic process (GO:0010896)4.01461232
62macromolecular complex remodeling (GO:0034367)4.00569989
63plasma lipoprotein particle remodeling (GO:0034369)4.00569989
64protein-lipid complex remodeling (GO:0034368)4.00569989
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.00558653
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99783044
67bile acid metabolic process (GO:0008206)3.98311072
68cotranslational protein targeting to membrane (GO:0006613)3.93525610
69protein targeting to ER (GO:0045047)3.92369830
70short-chain fatty acid metabolic process (GO:0046459)3.91889991
71reverse cholesterol transport (GO:0043691)3.90331637
72regulation of protein activation cascade (GO:2000257)3.88900887
73regulation of fibrinolysis (GO:0051917)3.84655795
74nitrogen cycle metabolic process (GO:0071941)3.81087105
75pyrimidine nucleoside catabolic process (GO:0046135)3.81084028
76chaperone-mediated protein transport (GO:0072321)3.77220913
77alpha-linolenic acid metabolic process (GO:0036109)3.76519560
78response to nitrosative stress (GO:0051409)3.76359415
79protein localization to endoplasmic reticulum (GO:0070972)3.76135670
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75564090
81acylglycerol homeostasis (GO:0055090)3.75097821
82triglyceride homeostasis (GO:0070328)3.75097821
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.74903175
84exogenous drug catabolic process (GO:0042738)3.73649937
85amino-acid betaine metabolic process (GO:0006577)3.72525158
86drug metabolic process (GO:0017144)3.69151977
87vitamin transmembrane transport (GO:0035461)3.65877031
88aromatic amino acid family metabolic process (GO:0009072)3.65350095
89regulation of complement activation (GO:0030449)3.61527228
90regulation of bile acid biosynthetic process (GO:0070857)3.59431892
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57252003
92protein neddylation (GO:0045116)3.55868596
93translational elongation (GO:0006414)3.55029016
94phospholipid homeostasis (GO:0055091)3.52267913
95primary alcohol catabolic process (GO:0034310)3.50995261
96pyrimidine nucleotide catabolic process (GO:0006244)3.49364202
97benzene-containing compound metabolic process (GO:0042537)3.48447681
98ethanol metabolic process (GO:0006067)3.48183055
99hydrogen ion transmembrane transport (GO:1902600)3.48110614
100protein carboxylation (GO:0018214)3.47656947
101peptidyl-glutamic acid carboxylation (GO:0017187)3.47656947
102ethanol oxidation (GO:0006069)3.46036939
103regulation of mitochondrial translation (GO:0070129)3.45482710
104cholesterol homeostasis (GO:0042632)3.43985075
105low-density lipoprotein particle remodeling (GO:0034374)3.43574439
106positive regulation of prostaglandin secretion (GO:0032308)3.42371947
107plasma lipoprotein particle clearance (GO:0034381)3.41948976
108cellular amino acid catabolic process (GO:0009063)3.40765557
109plasma lipoprotein particle assembly (GO:0034377)3.40620506
110deoxyribonucleotide catabolic process (GO:0009264)3.39017277
111base-excision repair, AP site formation (GO:0006285)3.38977613
112sterol homeostasis (GO:0055092)3.38316410
113sulfate transmembrane transport (GO:1902358)3.37629820
114intestinal cholesterol absorption (GO:0030299)3.35990202
115very-low-density lipoprotein particle assembly (GO:0034379)3.35143957
116alpha-amino acid catabolic process (GO:1901606)3.33365396
117cholesterol efflux (GO:0033344)3.32851344
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31989848
119regulation of cholesterol metabolic process (GO:0090181)3.31156259
120regulation of cholesterol homeostasis (GO:2000188)3.29005822
121proton transport (GO:0015992)3.28899521
122regulation of guanylate cyclase activity (GO:0031282)3.28888442
123fructose metabolic process (GO:0006000)3.28078411
124negative regulation of fatty acid metabolic process (GO:0045922)3.27951226
125drug transmembrane transport (GO:0006855)3.26537802
126deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.25618478
127acute-phase response (GO:0006953)3.24329142
128hydrogen transport (GO:0006818)3.23136467
129aldehyde catabolic process (GO:0046185)3.22795858
130negative regulation of fatty acid biosynthetic process (GO:0045717)3.22278631
131lipoprotein metabolic process (GO:0042157)3.21897262
132tyrosine metabolic process (GO:0006570)3.20841235
133viral life cycle (GO:0019058)3.20252889
134pyrimidine nucleoside salvage (GO:0043097)3.19817783
135pyrimidine-containing compound salvage (GO:0008655)3.19817783
136positive regulation of lipoprotein lipase activity (GO:0051006)3.18794101
137positive regulation of triglyceride lipase activity (GO:0061365)3.18794101
138chondrocyte proliferation (GO:0035988)3.18378217
139deoxyribose phosphate catabolic process (GO:0046386)3.17112971
140pyrimidine ribonucleoside catabolic process (GO:0046133)3.16210604
141epithelial cilium movement (GO:0003351)3.14815437
142regulation of cellular amino acid metabolic process (GO:0006521)3.12195721
143purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.10922586
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09869507
145ATP biosynthetic process (GO:0006754)3.08464882
146axonemal dynein complex assembly (GO:0070286)3.08347690
147maturation of SSU-rRNA (GO:0030490)3.08322142
148rRNA modification (GO:0000154)3.05725340
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04379844
150transcription elongation from RNA polymerase III promoter (GO:0006385)3.04235956
151termination of RNA polymerase III transcription (GO:0006386)3.04235956
152purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04004149
153purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02146990
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01386575
155ribosomal small subunit biogenesis (GO:0042274)3.00960878
156platelet dense granule organization (GO:0060155)3.00428818
157purine deoxyribonucleotide catabolic process (GO:0009155)2.99228367
158cellular protein complex disassembly (GO:0043624)2.98870360
159mannosylation (GO:0097502)2.96738293
160response to interferon-beta (GO:0035456)2.92158701
161translation (GO:0006412)2.92095338
162GPI anchor biosynthetic process (GO:0006506)2.91680668
163water-soluble vitamin biosynthetic process (GO:0042364)2.88117622
164cilium movement (GO:0003341)2.86302004
165negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85762613
166pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84796821
167GTP biosynthetic process (GO:0006183)2.82140330
168axoneme assembly (GO:0035082)2.81703741
169regulation of cilium movement (GO:0003352)2.80663951
170oxidative phosphorylation (GO:0006119)2.79812534
171negative regulation of B cell apoptotic process (GO:0002903)2.78983403
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78422985
173nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78062023
174inner mitochondrial membrane organization (GO:0007007)2.77385598
1752-deoxyribonucleotide metabolic process (GO:0009394)2.76463885
176GPI anchor metabolic process (GO:0006505)2.73597827
177translational initiation (GO:0006413)2.72438296
178preassembly of GPI anchor in ER membrane (GO:0016254)2.71155750
179positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.71057213
180purine deoxyribonucleotide metabolic process (GO:0009151)2.69693374
181negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.68115267
182signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67658550
183signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67658550
184signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67658550
185pseudouridine synthesis (GO:0001522)2.67649853
186intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65308332
187signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65308332
188branched-chain amino acid catabolic process (GO:0009083)2.65244938
189cellular response to interferon-beta (GO:0035458)2.64039255
190negative regulation of telomere maintenance (GO:0032205)2.64012533
191deoxyribose phosphate metabolic process (GO:0019692)2.62744341
192positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62328080
193proteasome assembly (GO:0043248)2.62196571
194protein targeting to mitochondrion (GO:0006626)2.61752266
195ribonucleoside triphosphate biosynthetic process (GO:0009201)2.58862971
196positive regulation of respiratory burst (GO:0060267)2.58229099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.04052013
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.53468439
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.03175449
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.59561755
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.01034171
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89394496
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.26705524
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18118396
9GABP_17652178_ChIP-ChIP_JURKAT_Human4.03642213
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.83516166
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.62366712
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.61608072
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.50144747
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40380815
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.25766744
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23351603
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02492614
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.02085760
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.87492344
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.83993282
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.82810053
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.76896232
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.76488441
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.68577967
25VDR_23849224_ChIP-Seq_CD4+_Human2.64059599
26SRY_22984422_ChIP-ChIP_TESTIS_Rat2.55090930
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.54196261
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43538710
29SOX2_27498859_Chip-Seq_STOMACH_Mouse2.41302552
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39919076
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34787413
32FOXP3_21729870_ChIP-Seq_TREG_Human2.29490457
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28583826
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04237480
35BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.04162612
36CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00642740
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92299719
38ELK1_19687146_ChIP-ChIP_HELA_Human1.90505910
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90364771
40ZNF274_21170338_ChIP-Seq_K562_Hela1.87628560
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.84057497
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82863356
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78400284
44GATA4_25053715_ChIP-Seq_YYC3_Human1.77167040
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76341811
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.72585822
47SOX2_20726797_ChIP-Seq_SW620_Human1.71204084
48MYC_18940864_ChIP-ChIP_HL60_Human1.69877790
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69732150
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69552989
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63896507
52* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62580401
53TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60339608
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.59686601
55VDR_22108803_ChIP-Seq_LS180_Human1.57951467
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53646570
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50818174
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50762631
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49548825
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48788578
61GATA6_25053715_ChIP-Seq_YYC3_Human1.48211212
62GABP_19822575_ChIP-Seq_HepG2_Human1.46209127
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45258213
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42322630
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41127389
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39499308
67HTT_18923047_ChIP-ChIP_STHdh_Human1.38879665
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38368994
69TP53_22573176_ChIP-Seq_HFKS_Human1.38362488
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36176404
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35472674
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35230969
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33383627
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.33383627
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32124327
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30115476
77AR_20517297_ChIP-Seq_VCAP_Human1.29932883
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28887261
79TTF2_22483619_ChIP-Seq_HELA_Human1.28683361
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26240368
81HNF4A_19822575_ChIP-Seq_HepG2_Human1.25357909
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24548052
83IRF1_19129219_ChIP-ChIP_H3396_Human1.23570442
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23165121
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22842468
86IGF1R_20145208_ChIP-Seq_DFB_Human1.22465407
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.21737442
88* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20566863
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20382399
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18799363
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18746662
92EGR1_19032775_ChIP-ChIP_M12_Human1.14191235
93CLOCK_20551151_ChIP-Seq_293T_Human1.14138364
94CIITA_25753668_ChIP-Seq_RAJI_Human1.13676309
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13643707
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13530892
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13389249
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.12975260
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11991688
100XRN2_22483619_ChIP-Seq_HELA_Human1.11306745
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.11135152
102DCP1A_22483619_ChIP-Seq_HELA_Human1.10698230
103RACK7_27058665_Chip-Seq_MCF-7_Human1.10360277
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09875211
105ERG_20517297_ChIP-Seq_VCAP_Human1.08637858
106P300_27268052_Chip-Seq_Bcells_Human1.08239915
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08012699
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08002537
109* KDM5A_27292631_Chip-Seq_BREAST_Human1.07329924
110ERA_21632823_ChIP-Seq_H3396_Human1.06932897
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.06852961
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06789854
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04944805
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03131457
115NCOR_22424771_ChIP-Seq_293T_Human1.02999481
116* GATA3_26560356_Chip-Seq_TH2_Human1.02360882
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01385412
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00963238
119MYC_19829295_ChIP-Seq_ESCs_Human1.00308504
120STAT1_20625510_ChIP-Seq_HELA_Human0.99560807
121NANOG_20526341_ChIP-Seq_ESCs_Human0.99536397
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98554364
123ZNF263_19887448_ChIP-Seq_K562_Human0.98026884
124RARA_24833708_ChIP-Seq_LIVER_Mouse0.97689695
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.97551402
126* YY1_22570637_ChIP-Seq_MALME-3M_Human0.97166812
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96534080
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96292888
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95548707
130* TAF2_19829295_ChIP-Seq_ESCs_Human0.94000521
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92834996
132LXR_22292898_ChIP-Seq_THP-1_Human0.92463894
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.90961094
134CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89957599
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89942278
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89355702
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.89270801
138RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89210482
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89115791
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88830928
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88777390
142SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88672755
143MYB_26560356_Chip-Seq_TH2_Human0.88379555
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.87762044
145SPI1_23547873_ChIP-Seq_NB4_Human0.87690024
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86572922
147NANOG_19829295_ChIP-Seq_ESCs_Human0.86174144
148SOX2_19829295_ChIP-Seq_ESCs_Human0.86174144
149MYC_19915707_ChIP-ChIP_AK7_Human0.85502331
150SA1_27219007_Chip-Seq_Bcells_Human0.84466389
151BCOR_27268052_Chip-Seq_Bcells_Human0.84448948
152TRIM28_21343339_ChIP-Seq_HEK293_Human0.83776636
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.83421038
154CTCF_20526341_ChIP-Seq_ESCs_Human0.81755959
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81658464
156CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80562435
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80157590
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.78277118
159FOXA1_25552417_ChIP-Seq_VCAP_Human0.77625656
160STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77511956
161CTCF_27219007_Chip-Seq_Bcells_Human0.76983786
162CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76622247
163SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75943514
164SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75416691
165GATA3_21867929_ChIP-Seq_CD8_Mouse0.72949365
166P53_21459846_ChIP-Seq_SAOS-2_Human0.72532570
167PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72503942
168TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.72168358
169BCL6_27268052_Chip-Seq_Bcells_Human0.71780604
170ATF3_27146783_Chip-Seq_COLON_Human0.71395970
171GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70513090
172ESR1_20079471_ChIP-ChIP_T-47D_Human0.69877099
173ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68895179
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.68878343
175GATA3_24758297_ChIP-Seq_MCF-7_Human0.68064049
176FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66442112
177MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65581371
178BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65293444
179ERG_21242973_ChIP-ChIP_JURKAT_Human0.65055492
180* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.64190130
181E2F1_20622854_ChIP-Seq_HELA_Human0.64144242
182GATA2_19941826_ChIP-Seq_K562_Human0.62709024
183FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62246569
184ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61480198
185SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61477805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.69387031
2MP0005360_urolithiasis6.25020213
3MP0005085_abnormal_gallbladder_physiolo5.34784902
4MP0005365_abnormal_bile_salt4.97384389
5MP0010234_abnormal_vibrissa_follicle4.96683249
6MP0003283_abnormal_digestive_organ4.67117051
7MP0008875_abnormal_xenobiotic_pharmacok4.48627299
8MP0003806_abnormal_nucleotide_metabolis4.03762579
9MP0003252_abnormal_bile_duct3.59249014
10MP0009379_abnormal_foot_pigmentation3.04545636
11MP0001666_abnormal_nutrient_absorption3.03797078
12MP0005645_abnormal_hypothalamus_physiol2.80764999
13MP0010329_abnormal_lipoprotein_level2.67801009
14MP0003787_abnormal_imprinting2.65906268
15MP0005075_abnormal_melanosome_morpholog2.45247582
16MP0009840_abnormal_foam_cell2.42972565
17MP0002822_catalepsy2.42808022
18MP0005377_hearing/vestibular/ear_phenot2.41975780
19MP0003878_abnormal_ear_physiology2.41975780
20MP0006292_abnormal_olfactory_placode2.33953017
21MP0002653_abnormal_ependyma_morphology2.28072926
22MP0008877_abnormal_DNA_methylation2.27271908
23MP0003191_abnormal_cellular_cholesterol2.23920354
24MP0005671_abnormal_response_to2.23911667
25MP0005332_abnormal_amino_acid2.18618176
26MP0000462_abnormal_digestive_system2.13459552
27MP0004019_abnormal_vitamin_homeostasis2.06276672
28MP0002138_abnormal_hepatobiliary_system2.04306210
29MP0005083_abnormal_biliary_tract2.01121837
30MP0006072_abnormal_retinal_apoptosis1.99214515
31MP0004147_increased_porphyrin_level1.81376065
32MP0002837_dystrophic_cardiac_calcinosis1.75171012
33MP0002277_abnormal_respiratory_mucosa1.72554893
34MP0008995_early_reproductive_senescence1.72133462
35MP0003868_abnormal_feces_composition1.69020528
36MP0009053_abnormal_anal_canal1.67888539
37MP0003195_calcinosis1.66696417
38MP0001835_abnormal_antigen_presentation1.64758900
39MP0002163_abnormal_gland_morphology1.64383949
40MP0005646_abnormal_pituitary_gland1.62399226
41MP0009643_abnormal_urine_homeostasis1.62051580
42MP0002118_abnormal_lipid_homeostasis1.61742592
43MP0000609_abnormal_liver_physiology1.60405057
44MP0001905_abnormal_dopamine_level1.59195532
45MP0005379_endocrine/exocrine_gland_phen1.55409687
46MP0004264_abnormal_extraembryonic_tissu1.51995541
47MP0001968_abnormal_touch/_nociception1.45415578
48MP0005084_abnormal_gallbladder_morpholo1.44921319
49MP0002148_abnormal_hypersensitivity_rea1.42233255
50MP0001984_abnormal_olfaction1.41182959
51MP0003866_abnormal_defecation1.38912111
52MP0010155_abnormal_intestine_physiology1.38490501
53MP0000372_irregular_coat_pigmentation1.37944356
54MP0005451_abnormal_body_composition1.37656949
55MP0001986_abnormal_taste_sensitivity1.37523875
56MP0002736_abnormal_nociception_after1.36379499
57MP0008789_abnormal_olfactory_epithelium1.34888703
58MP0003786_premature_aging1.33848155
59MP0005551_abnormal_eye_electrophysiolog1.33261379
60MP0005636_abnormal_mineral_homeostasis1.31782769
61MP0005319_abnormal_enzyme/_coenzyme1.30674408
62MP0001800_abnormal_humoral_immune1.30046157
63MP0003315_abnormal_perineum_morphology1.28282797
64MP0005381_digestive/alimentary_phenotyp1.28177914
65MP0000477_abnormal_intestine_morphology1.27101930
66MP0008058_abnormal_DNA_repair1.26587286
67MP0004142_abnormal_muscle_tone1.24974203
68MP0002909_abnormal_adrenal_gland1.24554724
69MP0004133_heterotaxia1.22323422
70MP0002693_abnormal_pancreas_physiology1.20743033
71MP0006276_abnormal_autonomic_nervous1.20468898
72MP0002234_abnormal_pharynx_morphology1.19091423
73MP0001663_abnormal_digestive_system1.18492809
74MP0001485_abnormal_pinna_reflex1.18463742
75MP0003705_abnormal_hypodermis_morpholog1.17087131
76MP0005584_abnormal_enzyme/coenzyme_acti1.16998329
77MP0003186_abnormal_redox_activity1.10729879
78MP0001873_stomach_inflammation1.10593539
79MP0002723_abnormal_immune_serum1.10181780
80MP0005387_immune_system_phenotype1.09942251
81MP0001790_abnormal_immune_system1.09942251
82MP0005000_abnormal_immune_tolerance1.09659745
83MP0001764_abnormal_homeostasis1.08977024
84MP0005410_abnormal_fertilization1.06417755
85MP0001819_abnormal_immune_cell1.06071974
86MP0002420_abnormal_adaptive_immunity1.05852024
87MP0005025_abnormal_response_to1.05763885
88MP0003121_genomic_imprinting1.03970676
89MP0003763_abnormal_thymus_physiology1.03875200
90MP0005167_abnormal_blood-brain_barrier1.01645055
91MP0002132_abnormal_respiratory_system1.00624365
92MP0010386_abnormal_urinary_bladder1.00543168
93MP0002160_abnormal_reproductive_system1.00102144
94MP0002452_abnormal_antigen_presenting0.99528792
95MP0002638_abnormal_pupillary_reflex0.99341935
96MP0005253_abnormal_eye_physiology0.98341863
97MP0005389_reproductive_system_phenotype0.98264938
98MP0000465_gastrointestinal_hemorrhage0.96386094
99MP0002796_impaired_skin_barrier0.94354632
100MP0005394_taste/olfaction_phenotype0.93785967
101MP0005499_abnormal_olfactory_system0.93785967
102MP0000689_abnormal_spleen_morphology0.90638437
103MP0009333_abnormal_splenocyte_physiolog0.90558539
104MP0001756_abnormal_urination0.90320817
105MP0001944_abnormal_pancreas_morphology0.86145245
106MP0000631_abnormal_neuroendocrine_gland0.85818144
107MP0005174_abnormal_tail_pigmentation0.85595889
108MP0000490_abnormal_crypts_of0.85488291
109MP0001188_hyperpigmentation0.85443928
110MP0001919_abnormal_reproductive_system0.83148866
111MP0003453_abnormal_keratinocyte_physiol0.82380998
112MP0004782_abnormal_surfactant_physiolog0.81888583
113MP0002102_abnormal_ear_morphology0.81839950
114MP0002166_altered_tumor_susceptibility0.81252300
115MP0003122_maternal_imprinting0.80495390
116MP0003880_abnormal_central_pattern0.79854196
117MP0009785_altered_susceptibility_to0.79338842
118MP0002398_abnormal_bone_marrow0.79126434
119MP0000716_abnormal_immune_system0.78924317
120MP0000598_abnormal_liver_morphology0.77672457
121MP0001664_abnormal_digestion0.73653747
122MP0009642_abnormal_blood_homeostasis0.72977092
123MP0003300_gastrointestinal_ulcer0.72426168
124MP0001765_abnormal_ion_homeostasis0.71413712
125MP0008469_abnormal_protein_level0.69647158
126MP0005166_decreased_susceptibility_to0.67424900
127MP0002136_abnormal_kidney_physiology0.67204077
128MP0003011_delayed_dark_adaptation0.66193001
129MP0004947_skin_inflammation0.65427065
130MP0005266_abnormal_metabolism0.63452063
131MP0005647_abnormal_sex_gland0.63381619
132MP0000613_abnormal_salivary_gland0.63005355
133MP0009763_increased_sensitivity_to0.62588900
134MP0002876_abnormal_thyroid_physiology0.60258260
135MP0000538_abnormal_urinary_bladder0.60106941
136MP0005376_homeostasis/metabolism_phenot0.59346340
137MP0009697_abnormal_copulation0.58368026
138MP0000604_amyloidosis0.54743751
139MP0002928_abnormal_bile_duct0.53834153
140MP0008873_increased_physiological_sensi0.52620270
141MP0005058_abnormal_lysosome_morphology0.52306351
142MP0006035_abnormal_mitochondrial_morpho0.51450164
143MP0008872_abnormal_physiological_respon0.51414292
144MP0002098_abnormal_vibrissa_morphology0.50630531
145MP0003718_maternal_effect0.50595601
146MP0004043_abnormal_pH_regulation0.49487500
147MP0009764_decreased_sensitivity_to0.49031294
148MP0010678_abnormal_skin_adnexa0.46827646
149MP0009765_abnormal_xenobiotic_induced0.46696500
150MP0005448_abnormal_energy_balance0.46681692
151MP0006036_abnormal_mitochondrial_physio0.46614625
152MP0000467_abnormal_esophagus_morphology0.46457070
153MP0001845_abnormal_inflammatory_respons0.46361501
154MP0003879_abnormal_hair_cell0.45124206
155MP0000537_abnormal_urethra_morphology0.44457075
156MP0005408_hypopigmentation0.44302500
157MP0005220_abnormal_exocrine_pancreas0.43535213
158MP0002060_abnormal_skin_morphology0.41815887
159MP0002254_reproductive_system_inflammat0.41475368
160MP0001216_abnormal_epidermal_layer0.40790655
161MP0006082_CNS_inflammation0.40777790
162MP0010352_gastrointestinal_tract_polyps0.40661009
163MP0000470_abnormal_stomach_morphology0.38808777
164MP0003656_abnormal_erythrocyte_physiolo0.38357600
165MP0002078_abnormal_glucose_homeostasis0.38315923
166MP0003638_abnormal_response/metabolism_0.38107142
167MP0000762_abnormal_tongue_morphology0.37338952

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.23006659
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.01621002
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.01582287
4Deep venous thrombosis (HP:0002625)4.70052272
5Acute necrotizing encephalopathy (HP:0006965)4.69230364
6Mitochondrial inheritance (HP:0001427)4.64553821
7Flat acetabular roof (HP:0003180)4.59950075
8Abnormal mitochondria in muscle tissue (HP:0008316)4.46498278
9Xanthomatosis (HP:0000991)4.31613394
10Abnormality of the 1st metacarpal (HP:0010009)4.30552373
11Hepatocellular necrosis (HP:0001404)4.20108817
12Hypobetalipoproteinemia (HP:0003563)4.16084036
13Prolonged partial thromboplastin time (HP:0003645)4.06302133
14Abnormal tarsal ossification (HP:0008369)4.02443550
15Progressive macrocephaly (HP:0004481)4.02074581
16Increased CSF lactate (HP:0002490)3.91235629
17Hepatic necrosis (HP:0002605)3.88374184
18Cupped ribs (HP:0000887)3.82894900
19Abnormality of carpal bone ossification (HP:0006257)3.78867640
20Hyperlipoproteinemia (HP:0010980)3.59065827
21Complement deficiency (HP:0004431)3.56789434
22Hyperglycinemia (HP:0002154)3.52197844
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51007947
24Hyperglycinuria (HP:0003108)3.46752896
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.44378643
26Hyperammonemia (HP:0001987)3.38975720
27Abnormal cartilage morphology (HP:0002763)3.31267330
28Symphalangism affecting the phalanges of the hand (HP:0009773)3.29989132
29Pustule (HP:0200039)3.26978355
30Abnormality of the distal phalanx of the thumb (HP:0009617)3.25065013
31Hypolipoproteinemia (HP:0010981)3.22781704
32Neonatal short-limb short stature (HP:0008921)3.21029695
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16255167
34Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16255167
353-Methylglutaconic aciduria (HP:0003535)3.12827298
36Fat malabsorption (HP:0002630)3.11138801
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09589114
38Hypoglycemic coma (HP:0001325)2.99203426
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.97331353
40Conjugated hyperbilirubinemia (HP:0002908)2.95457813
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.93666962
42Dicarboxylic aciduria (HP:0003215)2.93666962
43Abnormality of serine family amino acid metabolism (HP:0010894)2.93644123
44Abnormality of glycine metabolism (HP:0010895)2.93644123
45Abnormality of complement system (HP:0005339)2.91789141
46Abnormal respiratory motile cilium physiology (HP:0012261)2.91046759
47Joint hemorrhage (HP:0005261)2.90453783
48Hypoalphalipoproteinemia (HP:0003233)2.90443684
49Short phalanx of the thumb (HP:0009660)2.87235824
50Abnormal number of erythroid precursors (HP:0012131)2.87024507
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.86849274
52Abnormality of fatty-acid metabolism (HP:0004359)2.86767101
53Pancreatic cysts (HP:0001737)2.85861701
54Abnormality of the proximal phalanges of the hand (HP:0009834)2.84312419
55Pancreatic fibrosis (HP:0100732)2.82475346
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.79684696
57Absent/shortened dynein arms (HP:0200106)2.79684696
58Spontaneous abortion (HP:0005268)2.79343150
59Posterior subcapsular cataract (HP:0007787)2.78921731
60Ileus (HP:0002595)2.78510481
61Abnormal respiratory epithelium morphology (HP:0012253)2.77304804
62Abnormal respiratory motile cilium morphology (HP:0005938)2.77304804
63Abnormality of the 2nd finger (HP:0004100)2.75508677
64Abnormal ciliary motility (HP:0012262)2.73843629
65Malnutrition (HP:0004395)2.73217907
66Abnormality of cells of the erythroid lineage (HP:0012130)2.72460604
67Abnormal ossification of hand bones (HP:0005921)2.70372274
68Cerebral edema (HP:0002181)2.67408491
69Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.66823798
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66195581
71Abnormal hand bone ossification (HP:0010660)2.64466423
72Abnormality of midbrain morphology (HP:0002418)2.63802772
73Molar tooth sign on MRI (HP:0002419)2.63802772
74Acute encephalopathy (HP:0006846)2.63740578
75Lactic acidosis (HP:0003128)2.63589781
76Abnormality of the middle phalanges of the toes (HP:0010183)2.59145953
77Nephronophthisis (HP:0000090)2.58405645
78Exertional dyspnea (HP:0002875)2.56287532
79Aplastic anemia (HP:0001915)2.53968590
80Hypercholesterolemia (HP:0003124)2.53452770
81True hermaphroditism (HP:0010459)2.53419982
82Lethargy (HP:0001254)2.52211471
83Abnormality of the phalanges of the hallux (HP:0010057)2.50588164
84Chronic bronchitis (HP:0004469)2.50259422
85Abnormality of pyrimidine metabolism (HP:0004353)2.48956811
86Abdominal distention (HP:0003270)2.48895738
87Abnormality of the common coagulation pathway (HP:0010990)2.48206464
88Exercise intolerance (HP:0003546)2.48092997
89Respiratory failure (HP:0002878)2.46504940
90Rhinitis (HP:0012384)2.45744896
91Lipid accumulation in hepatocytes (HP:0006561)2.44509932
92Alopecia of scalp (HP:0002293)2.43884841
93Alkalosis (HP:0001948)2.42550019
94Abnormality of renal resorption (HP:0011038)2.42488327
95Ketosis (HP:0001946)2.41621392
96Esophageal varix (HP:0002040)2.40982308
97Flat capital femoral epiphysis (HP:0003370)2.40647508
98Increased serum lactate (HP:0002151)2.40121997
99Epidermoid cyst (HP:0200040)2.39886490
100Late onset (HP:0003584)2.39823285
101Reticulocytopenia (HP:0001896)2.39704996
102Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.39073673
103Abnormal foot bone ossification (HP:0010675)2.38546863
104Increased muscle lipid content (HP:0009058)2.38496745
105Abnormality of urine glucose concentration (HP:0011016)2.38377852
106Glycosuria (HP:0003076)2.38377852
107Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38140511
108Optic disc pallor (HP:0000543)2.36551034
109Right ventricular cardiomyopathy (HP:0011663)2.36531218
110Medial flaring of the eyebrow (HP:0010747)2.36417337
111Absent phalangeal crease (HP:0006109)2.35492354
112Hyperbilirubinemia (HP:0002904)2.34183763
113Abnormal rod and cone electroretinograms (HP:0008323)2.33891607
114Abnormality of methionine metabolism (HP:0010901)2.32215355
115Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31466001
116Short middle phalanx of finger (HP:0005819)2.30540331
117Increased intramyocellular lipid droplets (HP:0012240)2.29477603
118Vertebral clefting (HP:0008428)2.29436764
119Type I transferrin isoform profile (HP:0003642)2.29351832
120Abnormality of nucleobase metabolism (HP:0010932)2.27257475
121Methylmalonic acidemia (HP:0002912)2.25846241
122Congenital stationary night blindness (HP:0007642)2.24140191
123Flattened epiphyses (HP:0003071)2.22541491
124Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18100897
125Irregular epiphyses (HP:0010582)2.16479393
126Abnormality of purine metabolism (HP:0004352)2.16407807
127Metabolic alkalosis (HP:0200114)2.15603712
128Increased hepatocellular lipid droplets (HP:0006565)2.14749240
129Cerebral palsy (HP:0100021)2.14695594
130Methylmalonic aciduria (HP:0012120)2.14596786
131Abnormality of the renal cortex (HP:0011035)2.14450473
132Agammaglobulinemia (HP:0004432)2.14154397
133Glomerulonephritis (HP:0000099)2.13509039
134Hyperphosphaturia (HP:0003109)2.11308478
135Renal cortical cysts (HP:0000803)2.10707020
136Respiratory difficulties (HP:0002880)2.09263108
137Metabolic acidosis (HP:0001942)2.08687300
138Bronchiectasis (HP:0002110)2.08496569
139Abnormality of the renal medulla (HP:0100957)2.08431082
140Steatorrhea (HP:0002570)2.08053861
141Macrocytic anemia (HP:0001972)2.07845439
142Short hallux (HP:0010109)2.07041508
143Abnormal biliary tract physiology (HP:0012439)2.06947838
144Bile duct proliferation (HP:0001408)2.06947838
145Gingival bleeding (HP:0000225)2.06777038
146Severe combined immunodeficiency (HP:0004430)2.06098518
147Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.04727929
148Renal Fanconi syndrome (HP:0001994)2.01734947
149Gout (HP:0001997)2.01568299
150Elevated erythrocyte sedimentation rate (HP:0003565)2.01063300
151Abnormal glycosylation (HP:0012345)2.00089443
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00089443
153Abnormal protein N-linked glycosylation (HP:0012347)2.00089443
154Abnormal protein glycosylation (HP:0012346)2.00089443
155Colon cancer (HP:0003003)1.99246479
156Abolished electroretinogram (ERG) (HP:0000550)1.98982466
157Hypothermia (HP:0002045)1.98409867
158Chronic sinusitis (HP:0011109)1.96311275
159Aplasia/hypoplasia of the femur (HP:0005613)1.95924663
160Bronchitis (HP:0012387)1.95841946
161Cheilitis (HP:0100825)1.95315303
162Short tibia (HP:0005736)1.94570372
163Breech presentation (HP:0001623)1.93330277
164Vascular calcification (HP:0004934)1.92935324
165IgG deficiency (HP:0004315)1.92006430
166Stomatitis (HP:0010280)1.91475736
167Pancytopenia (HP:0001876)1.88334005
168Leukodystrophy (HP:0002415)1.87768944
169Ketoacidosis (HP:0001993)1.87744598
170Congenital primary aphakia (HP:0007707)1.85067724
171Generalized aminoaciduria (HP:0002909)1.80423720
172Gait imbalance (HP:0002141)1.80377114
173Recurrent sinusitis (HP:0011108)1.80096323
174Male pseudohermaphroditism (HP:0000037)1.79786496
175Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79391140
176Nephrogenic diabetes insipidus (HP:0009806)1.79101800
177Progressive microcephaly (HP:0000253)1.79072178
178Abnormality of the prostate (HP:0008775)1.72696914
179Cystic liver disease (HP:0006706)1.70750168
180Sclerocornea (HP:0000647)1.70539574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA4.86679355
2VRK24.77551297
3EPHB24.38462929
4MST1R3.23805008
5BCKDK3.18228191
6TXK3.06515616
7RIPK12.81489942
8STK162.75526983
9MAP2K22.60821151
10MAP4K22.55318871
11ZAK2.18482188
12VRK12.18172060
13FRK2.02762300
14TAOK310.9255507
15CDK191.96322084
16LMTK21.87332897
17MAP4K11.86987008
18ERN11.64752160
19GRK61.64637187
20TLK11.53417437
21PRKG21.50894966
22MAP3K111.43507717
23WNK31.42623060
24TNK21.41889019
25MYLK1.39459798
26ARAF1.39027340
27ADRBK21.38821263
28DYRK21.37224018
29BMPR1B1.34637106
30FGFR41.33321098
31NME11.31369887
32SIK11.30106682
33MAP3K21.29230945
34TAOK11.28553293
35DAPK11.25480585
36TESK21.24733651
37MAP3K141.16547192
38IKBKB1.13504720
39SCYL21.13006955
40TAF11.09593912
41MAP3K71.09409058
42OXSR11.07631246
43KSR21.03857969
44NUAK11.01667290
45MUSK1.01275706
46TTK1.00066152
47MAPKAPK30.99822244
48ABL20.98328706
49KIT0.97415484
50NME20.96278617
51CAMK2D0.95446380
52PIK3CG0.91637928
53ERBB40.90096006
54MAP2K10.86867973
55MAPK150.83967460
56CSNK1G30.82027695
57DAPK30.80937233
58MAPK110.80886550
59CAMK2G0.80406399
60TYK20.80101343
61SYK0.79329214
62PTK60.77025407
63RPS6KA50.76650170
64PASK0.75846038
65CSNK1G10.74496438
66CSF1R0.73627517
67TEC0.73431573
68ERBB20.73289819
69PIM20.72964613
70LRRK20.70900891
71PKN20.70879201
72PINK10.69757244
73CSK0.69748743
74LIMK10.69514201
75CDC70.69275106
76DAPK20.68652701
77TESK10.68302102
78TNIK0.67065114
79CSNK1G20.66891425
80BTK0.63426224
81LCK0.63134029
82FES0.62378695
83MAP3K120.61607371
84BRAF0.61250901
85PRKCI0.58768149
86FLT30.57099747
87MAP2K60.56235309
88MAPK130.55879756
89MAP2K70.53585899
90CSNK2A20.51179938
91PDPK10.51151916
92PRKAA20.49609452
93AURKA0.49385838
94PRKCA0.49377974
95BMPR20.49211306
96GRK50.47937179
97PTK20.47507295
98CAMK2B0.46839830
99ADRBK10.46744505
100MATK0.46578152
101MET0.46563116
102CSNK1A1L0.46488820
103ILK0.45573251
104WNK40.45056524
105RIPK40.44156011
106BUB10.43370804
107MAPK40.42766581
108ICK0.42437681
109TRIM280.41809478
110CSNK1A10.41393499
111TBK10.41290210
112DYRK30.41198320
113PIM10.41188868
114PRKCE0.40853395
115STK390.39958527
116PRKCQ0.39942690
117CSNK2A10.39864624
118KDR0.39035883
119PBK0.38310860
120PRKCZ0.38144233
121AURKB0.37875556
122PRKD20.37785007
123IKBKE0.37344032
124PLK10.36454019
125NEK90.35576786
126PRKACG0.35072118
127INSRR0.34131800
128RPS6KB20.33661992
129PDK10.33231386
130ATR0.32811485
131PRKCG0.32276124
132SRC0.30920122
133STK38L0.29750796
134MAP3K80.29164610
135ITK0.28669935
136JAK20.27672945
137CAMK1D0.27406166
138GRK10.26345164
139DYRK1B0.25569143
140DMPK0.25470855
141MST40.23956476
142MAP3K10.22872091
143LYN0.22284848
144SGK4940.21515339
145SGK2230.21515339
146STK110.17974032
147EPHB10.17483060
148PRKG10.17383446
149GSK3A0.16751702
150PAK10.16191229
151PHKG20.15292881
152PHKG10.15292881
153JAK10.12627335
154TRIB30.12069367
155PTK2B0.11871796
156PRKACB0.11809285
157PAK40.10446438
158PRKACA0.10356650
159PRKCD0.09670728
160PRKAA10.08774227
161CDK60.07992797

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.43658030
2Proteasome_Homo sapiens_hsa030503.55231014
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47286201
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.24750505
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.15445718
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.77371450
7Protein export_Homo sapiens_hsa030602.55805774
8Butanoate metabolism_Homo sapiens_hsa006502.55329977
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.52117426
10Chemical carcinogenesis_Homo sapiens_hsa052042.50050134
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.49037809
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39275093
13RNA polymerase_Homo sapiens_hsa030202.33215752
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28980265
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.28757255
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.18840539
17Tryptophan metabolism_Homo sapiens_hsa003802.16215662
18Sulfur relay system_Homo sapiens_hsa041222.13936190
19Fatty acid degradation_Homo sapiens_hsa000712.12871206
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09759124
21Nitrogen metabolism_Homo sapiens_hsa009102.07191888
22Primary immunodeficiency_Homo sapiens_hsa053402.06724697
23Arginine biosynthesis_Homo sapiens_hsa002202.01588626
24Histidine metabolism_Homo sapiens_hsa003401.98841279
25Complement and coagulation cascades_Homo sapiens_hsa046101.96278305
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89605804
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87582429
28Type I diabetes mellitus_Homo sapiens_hsa049401.86493505
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82388425
30Bile secretion_Homo sapiens_hsa049761.80599677
31Fat digestion and absorption_Homo sapiens_hsa049751.75803704
32Asthma_Homo sapiens_hsa053101.74419435
33PPAR signaling pathway_Homo sapiens_hsa033201.74040828
34Homologous recombination_Homo sapiens_hsa034401.69066170
35Autoimmune thyroid disease_Homo sapiens_hsa053201.67654881
36Propanoate metabolism_Homo sapiens_hsa006401.65379539
37Allograft rejection_Homo sapiens_hsa053301.64189028
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61977267
39Peroxisome_Homo sapiens_hsa041461.60006263
40Retinol metabolism_Homo sapiens_hsa008301.59898983
41Oxidative phosphorylation_Homo sapiens_hsa001901.58736734
42Graft-versus-host disease_Homo sapiens_hsa053321.57148141
43Mismatch repair_Homo sapiens_hsa034301.49645176
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45010940
45Phenylalanine metabolism_Homo sapiens_hsa003601.40532253
46Fatty acid metabolism_Homo sapiens_hsa012121.38085309
47Phototransduction_Homo sapiens_hsa047441.37357710
48beta-Alanine metabolism_Homo sapiens_hsa004101.33939782
49Staphylococcus aureus infection_Homo sapiens_hsa051501.33511055
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.32668254
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31728363
52Tyrosine metabolism_Homo sapiens_hsa003501.28358094
53Starch and sucrose metabolism_Homo sapiens_hsa005001.27794952
54Parkinsons disease_Homo sapiens_hsa050121.26324833
55Base excision repair_Homo sapiens_hsa034101.24327944
56DNA replication_Homo sapiens_hsa030301.22365992
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21056356
58Selenocompound metabolism_Homo sapiens_hsa004501.18291295
59Pyruvate metabolism_Homo sapiens_hsa006201.17587907
60Caffeine metabolism_Homo sapiens_hsa002321.12352139
61Carbon metabolism_Homo sapiens_hsa012001.09305509
62RNA degradation_Homo sapiens_hsa030181.08746406
63Glutathione metabolism_Homo sapiens_hsa004801.08149780
64Folate biosynthesis_Homo sapiens_hsa007901.07111444
65Antigen processing and presentation_Homo sapiens_hsa046121.06807997
66Fanconi anemia pathway_Homo sapiens_hsa034601.05428504
67Fructose and mannose metabolism_Homo sapiens_hsa000511.05160634
68Alzheimers disease_Homo sapiens_hsa050101.04759723
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.01200039
70Purine metabolism_Homo sapiens_hsa002301.00485292
71ABC transporters_Homo sapiens_hsa020100.99725887
72Fatty acid elongation_Homo sapiens_hsa000620.98971925
73Pentose phosphate pathway_Homo sapiens_hsa000300.96854463
74Collecting duct acid secretion_Homo sapiens_hsa049660.95352599
75Steroid biosynthesis_Homo sapiens_hsa001000.93383962
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93006348
77Rheumatoid arthritis_Homo sapiens_hsa053230.92001423
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90075600
79Mineral absorption_Homo sapiens_hsa049780.86367727
80Regulation of autophagy_Homo sapiens_hsa041400.85161863
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84104533
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82702040
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82003865
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81427156
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79088925
86Nucleotide excision repair_Homo sapiens_hsa034200.78355738
87Linoleic acid metabolism_Homo sapiens_hsa005910.77118858
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76104265
89Hematopoietic cell lineage_Homo sapiens_hsa046400.75712100
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75201538
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74203288
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71927621
93Glycerolipid metabolism_Homo sapiens_hsa005610.71803277
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.69749170
95Biosynthesis of amino acids_Homo sapiens_hsa012300.69261542
96Arginine and proline metabolism_Homo sapiens_hsa003300.69237446
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68719113
98Basal transcription factors_Homo sapiens_hsa030220.67710957
99Huntingtons disease_Homo sapiens_hsa050160.67697997
100Spliceosome_Homo sapiens_hsa030400.66127215
101Vitamin digestion and absorption_Homo sapiens_hsa049770.64822245
102Galactose metabolism_Homo sapiens_hsa000520.63469925
103Metabolic pathways_Homo sapiens_hsa011000.62872273
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58665656
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57140159
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49737717
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49248926
108Non-homologous end-joining_Homo sapiens_hsa034500.43554172
109Cardiac muscle contraction_Homo sapiens_hsa042600.43124813
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.39211868
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.38281813
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38193655
113Olfactory transduction_Homo sapiens_hsa047400.35919472
114N-Glycan biosynthesis_Homo sapiens_hsa005100.35693687
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35538039
116Vitamin B6 metabolism_Homo sapiens_hsa007500.32115165
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28071386
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27921792
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26024467
120Arachidonic acid metabolism_Homo sapiens_hsa005900.25090701
121Viral myocarditis_Homo sapiens_hsa054160.24282891
122Epstein-Barr virus infection_Homo sapiens_hsa051690.22195565
123Prion diseases_Homo sapiens_hsa050200.18588765
124One carbon pool by folate_Homo sapiens_hsa006700.11830148
125Renin-angiotensin system_Homo sapiens_hsa046140.08581440
126Pancreatic secretion_Homo sapiens_hsa049720.07303885
127Hepatitis C_Homo sapiens_hsa051600.07032421
128Bladder cancer_Homo sapiens_hsa052190.05442389
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05369658
130Systemic lupus erythematosus_Homo sapiens_hsa053220.02075988
131Tight junction_Homo sapiens_hsa045300.01627111
132Fatty acid biosynthesis_Homo sapiens_hsa000610.01215531
133Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0394368
134Ribosome_Homo sapiens_hsa03010-0.0202686
135African trypanosomiasis_Homo sapiens_hsa05143-0.0200749
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0162714
137Pyrimidine metabolism_Homo sapiens_hsa00240-0.0132841
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0108495
139Ether lipid metabolism_Homo sapiens_hsa00565-0.0035844
140Lysine degradation_Homo sapiens_hsa00310-0.0013305

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