TSTD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.19202289
2synapsis (GO:0007129)4.23905913
3piRNA metabolic process (GO:0034587)4.18109100
4nucleobase catabolic process (GO:0046113)4.09403366
5presynaptic membrane assembly (GO:0097105)4.01054635
6histone H2A acetylation (GO:0043968)3.79205317
7IMP biosynthetic process (GO:0006188)3.70156297
8regulation of meiosis I (GO:0060631)3.56847945
9positive regulation of mitochondrial fission (GO:0090141)3.47342872
10folic acid-containing compound biosynthetic process (GO:0009396)3.45550073
11IMP metabolic process (GO:0046040)3.45186278
12male meiosis (GO:0007140)3.38412357
13intraciliary transport (GO:0042073)3.26697684
14DNA unwinding involved in DNA replication (GO:0006268)3.20931986
15mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.19367850
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.19367850
17DNA methylation involved in gamete generation (GO:0043046)3.15111106
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13389045
19COPI coating of Golgi vesicle (GO:0048205)3.13332650
20Golgi transport vesicle coating (GO:0048200)3.13332650
21resolution of meiotic recombination intermediates (GO:0000712)3.09820754
22paraxial mesoderm development (GO:0048339)3.08227850
23presynaptic membrane organization (GO:0097090)3.02946440
24nonmotile primary cilium assembly (GO:0035058)3.01675041
25somite rostral/caudal axis specification (GO:0032525)2.99248549
26DNA strand elongation involved in DNA replication (GO:0006271)2.92638714
27neural tube formation (GO:0001841)2.90502760
28microtubule depolymerization (GO:0007019)2.87886992
29mitotic G1/S transition checkpoint (GO:0044819)2.85416766
30centriole replication (GO:0007099)2.83785731
31mitotic G1 DNA damage checkpoint (GO:0031571)2.83421394
32ncRNA 3-end processing (GO:0043628)2.80571239
33protein localization to endosome (GO:0036010)2.80048925
34protein K11-linked deubiquitination (GO:0035871)2.79232086
35neuron cell-cell adhesion (GO:0007158)2.79108936
36gene silencing by RNA (GO:0031047)2.78622985
37protein localization to cilium (GO:0061512)2.77966315
38DNA integration (GO:0015074)2.77581201
39chromosome organization involved in meiosis (GO:0070192)2.72000707
40postsynaptic membrane organization (GO:0001941)2.71615051
41DNA strand elongation (GO:0022616)2.68110202
42COPII vesicle coating (GO:0048208)2.67378465
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67343544
44male meiosis I (GO:0007141)2.67236274
45positive regulation of glycolytic process (GO:0045821)2.67019980
46positive regulation of mRNA processing (GO:0050685)2.66413730
47organelle disassembly (GO:1903008)2.64484121
48mitotic nuclear envelope disassembly (GO:0007077)2.63946014
49mitotic sister chromatid cohesion (GO:0007064)2.62217446
50mitochondrial DNA replication (GO:0006264)2.61952919
51histone H2A monoubiquitination (GO:0035518)2.61519497
52cilium morphogenesis (GO:0060271)2.61472989
53epithelial cilium movement (GO:0003351)2.61378635
54positive regulation of mitotic sister chromatid separation (GO:1901970)2.61132977
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61132977
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61132977
57protein polyglutamylation (GO:0018095)2.58918103
58nucleobase biosynthetic process (GO:0046112)2.56338750
59tetrahydrofolate metabolic process (GO:0046653)2.52780091
60positive regulation of histone H3-K4 methylation (GO:0051571)2.52431649
61protein K6-linked ubiquitination (GO:0085020)2.52090805
62DNA ligation (GO:0006266)2.49787472
63peptidyl-lysine trimethylation (GO:0018023)2.48549104
64regulation of histone H3-K9 methylation (GO:0051570)2.47670768
65DNA synthesis involved in DNA repair (GO:0000731)2.47508748
66positive regulation of dendritic spine morphogenesis (GO:0061003)2.47249556
67genitalia morphogenesis (GO:0035112)2.46696700
68sister chromatid cohesion (GO:0007062)2.46055632
69double-strand break repair via nonhomologous end joining (GO:0006303)2.45267581
70non-recombinational repair (GO:0000726)2.45267581
71nuclear pore complex assembly (GO:0051292)2.43962185
72regulation of spindle organization (GO:0090224)2.42754434
73T cell apoptotic process (GO:0070231)2.42488266
74creatine metabolic process (GO:0006600)2.41930549
75regulation of glucokinase activity (GO:0033131)2.41498690
76regulation of hexokinase activity (GO:1903299)2.41498690
77response to lipoprotein particle (GO:0055094)2.41037607
78meiotic nuclear division (GO:0007126)2.40559975
79negative regulation of DNA recombination (GO:0045910)2.40291431
80regulation of metalloenzyme activity (GO:0048552)2.39081142
81definitive hemopoiesis (GO:0060216)2.38988148
82histone H3-K9 demethylation (GO:0033169)2.37743074
83mitotic chromosome condensation (GO:0007076)2.37358323
84regulation of feeding behavior (GO:0060259)2.36289980
85histone H4-K8 acetylation (GO:0043982)2.36254032
86histone H4-K5 acetylation (GO:0043981)2.36254032
87cilium assembly (GO:0042384)2.34750040
88ribonucleoprotein complex disassembly (GO:0032988)2.34219196
89positive regulation of cell cycle checkpoint (GO:1901978)2.34197906
90cilium organization (GO:0044782)2.33312655
91positive regulation of response to extracellular stimulus (GO:0032106)2.33217467
92positive regulation of response to nutrient levels (GO:0032109)2.33217467
93pentose-phosphate shunt (GO:0006098)2.32721054
94spinal cord motor neuron differentiation (GO:0021522)2.32528195
95membrane disassembly (GO:0030397)2.31941083
96nuclear envelope disassembly (GO:0051081)2.31941083
97nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.31812600
98intra-Golgi vesicle-mediated transport (GO:0006891)2.31687698
99response to laminar fluid shear stress (GO:0034616)2.29982428
100nuclear pore organization (GO:0006999)2.29917644
101glomerular filtration (GO:0003094)2.29480982
102oocyte development (GO:0048599)2.29268230
103endoplasmic reticulum organization (GO:0007029)2.29091321
104NADPH regeneration (GO:0006740)2.28881505
105lymphocyte apoptotic process (GO:0070227)2.28166743
106renal filtration (GO:0097205)2.27542545
107protein localization to kinetochore (GO:0034501)2.27432834
108membrane protein intracellular domain proteolysis (GO:0031293)2.26591924
109neuron fate determination (GO:0048664)2.26522196
110aspartate family amino acid catabolic process (GO:0009068)2.26041530
111DNA topological change (GO:0006265)2.25647803
112pyrimidine dimer repair (GO:0006290)2.25140290
113lactate metabolic process (GO:0006089)2.23926751
114pteridine-containing compound biosynthetic process (GO:0042559)2.23857488
115retinal cone cell development (GO:0046549)2.23061767
116telomere maintenance via semi-conservative replication (GO:0032201)2.22670136
117DNA double-strand break processing (GO:0000729)2.22589163
118positive regulation of macroautophagy (GO:0016239)2.22339285
119limb bud formation (GO:0060174)2.22107694
120L-serine metabolic process (GO:0006563)2.21985639
121cilium movement (GO:0003341)2.21846663
122tRNA aminoacylation for protein translation (GO:0006418)2.20014857
123regulation of mRNA splicing, via spliceosome (GO:0048024)2.19760969
124protein localization to chromosome (GO:0034502)2.19728141
125viral mRNA export from host cell nucleus (GO:0046784)2.19652790
126negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.19519624
127negative regulation of translation, ncRNA-mediated (GO:0040033)2.19519624
128regulation of translation, ncRNA-mediated (GO:0045974)2.19519624
129positive regulation of meiosis (GO:0045836)2.19214967
130regulation of DNA endoreduplication (GO:0032875)2.18931374
131polyol catabolic process (GO:0046174)2.18772920
132inositol phosphate catabolic process (GO:0071545)2.18368930
133L-phenylalanine catabolic process (GO:0006559)2.18222914
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.18222914
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.17885091
136smoothened signaling pathway (GO:0007224)2.17837857
137growth hormone receptor signaling pathway (GO:0060396)2.17020915
138peptidyl-lysine dimethylation (GO:0018027)2.16828288
139meiotic cell cycle (GO:0051321)2.16783250
140calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.15923666
141alpha-linolenic acid metabolic process (GO:0036109)2.15670576
142axonal fasciculation (GO:0007413)2.15122473
143purine nucleobase biosynthetic process (GO:0009113)2.14856158
144myelin maintenance (GO:0043217)2.14707967
145DNA geometric change (GO:0032392)2.14621300
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.14238893
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.14238893
148protein K48-linked ubiquitination (GO:0070936)2.13861026
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.13816227
150positive regulation of RNA splicing (GO:0033120)2.13750671
151nucleotide transmembrane transport (GO:1901679)2.13749686
152histone-serine phosphorylation (GO:0035404)2.12986611
153serine family amino acid biosynthetic process (GO:0009070)2.10733430
154myeloid cell homeostasis (GO:0002262)2.10232219
155DNA duplex unwinding (GO:0032508)2.10226534
156regulation of gamma-delta T cell differentiation (GO:0045586)2.10035914
157regulation of necroptotic process (GO:0060544)2.09614680
158mitotic recombination (GO:0006312)2.08973288
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.08413549
160mesodermal cell differentiation (GO:0048333)2.08397750
161regulation of mitotic spindle organization (GO:0060236)2.07448483
162purine-containing compound salvage (GO:0043101)2.06014837
163histone mRNA catabolic process (GO:0071044)2.05852984
164cholesterol biosynthetic process (GO:0006695)2.05392203
165DNA replication initiation (GO:0006270)2.04026246
166hepatocyte apoptotic process (GO:0097284)2.03930498
167telomere maintenance via recombination (GO:0000722)2.03368930
168nuclear envelope organization (GO:0006998)2.02475671
169valine metabolic process (GO:0006573)2.02214956
170fatty acid elongation (GO:0030497)2.02036196
171sister chromatid segregation (GO:0000819)2.01836530
172retina vasculature morphogenesis in camera-type eye (GO:0061299)2.01449955
173centrosome duplication (GO:0051298)2.01285019
174glycine metabolic process (GO:0006544)2.01069597
175alternative mRNA splicing, via spliceosome (GO:0000380)2.00811217
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.00260733
177L-phenylalanine metabolic process (GO:0006558)2.00260733
178acetyl-CoA metabolic process (GO:0006084)1.99774480
179membrane protein ectodomain proteolysis (GO:0006509)1.99752283
180response to UV-C (GO:0010225)1.99611290
181regulation of translational fidelity (GO:0006450)1.99576458
182glucocorticoid receptor signaling pathway (GO:0042921)1.98983440
183amyloid precursor protein catabolic process (GO:0042987)1.98811340
184ER overload response (GO:0006983)1.98428585
185snRNA processing (GO:0016180)1.98163764
186membrane raft organization (GO:0031579)1.98104859
187dosage compensation (GO:0007549)1.97311353
188positive regulation of fatty acid beta-oxidation (GO:0032000)1.96090943
189positive regulation of T cell cytokine production (GO:0002726)1.95914670
190gap junction assembly (GO:0016264)1.95646297
191tricarboxylic acid metabolic process (GO:0072350)1.94351534
192antigen processing and presentation of endogenous antigen (GO:0019883)1.93248516
193coenzyme A metabolic process (GO:0015936)1.92918555
194chromatin assembly (GO:0031497)1.92882976
195positive regulation of transcription regulatory region DNA binding (GO:2000679)1.92734685
196somatic diversification of immune receptors via somatic mutation (GO:0002566)1.92292046
197somatic hypermutation of immunoglobulin genes (GO:0016446)1.92292046
198RNA stabilization (GO:0043489)1.91877488

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63769983
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.74604525
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.66365647
4IGF1R_20145208_ChIP-Seq_DFB_Human3.17393051
5ZNF274_21170338_ChIP-Seq_K562_Hela3.16150427
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95394316
7GBX2_23144817_ChIP-Seq_PC3_Human2.94538299
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82576101
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66210539
10TAF15_26573619_Chip-Seq_HEK293_Human2.64060278
11FUS_26573619_Chip-Seq_HEK293_Human2.57213235
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52487014
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35622034
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34250886
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32882821
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31975722
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30351050
18EZH2_22144423_ChIP-Seq_EOC_Human2.29236737
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.20514916
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19074808
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17962632
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15192113
23EWS_26573619_Chip-Seq_HEK293_Human2.15183541
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09181387
25AR_21909140_ChIP-Seq_LNCAP_Human2.06717391
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04218917
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03725220
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01836639
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00498420
30CIITA_25753668_ChIP-Seq_RAJI_Human1.99084829
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.98374001
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94909514
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88318088
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84947102
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84290814
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.83503929
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79678660
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79051549
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75852844
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75840430
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75409877
42CLOCK_20551151_ChIP-Seq_293T_Human1.74595795
43P300_19829295_ChIP-Seq_ESCs_Human1.68631616
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67595274
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67389564
46IRF1_19129219_ChIP-ChIP_H3396_Human1.65991259
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65554631
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61980069
49MYC_22102868_ChIP-Seq_BL_Human1.59904228
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56775630
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55698281
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55433700
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52829341
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52512996
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52280402
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.51263601
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.50343043
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50175098
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49170285
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48739268
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.47638114
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47605359
63SMAD4_21799915_ChIP-Seq_A2780_Human1.46915362
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46304110
65GATA1_22025678_ChIP-Seq_K562_Human1.46276488
66STAT3_23295773_ChIP-Seq_U87_Human1.46230214
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45753214
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45356541
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42861063
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42493099
71RNF2_27304074_Chip-Seq_NSC_Mouse1.42467934
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41489996
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41341716
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38614937
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38231395
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37893429
77CBP_20019798_ChIP-Seq_JUKART_Human1.36220102
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36220102
79XRN2_22483619_ChIP-Seq_HELA_Human1.35418150
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.35271948
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34453492
82VDR_22108803_ChIP-Seq_LS180_Human1.34118135
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.33435291
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32930906
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32749448
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32749448
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.32329945
88TFEB_21752829_ChIP-Seq_HELA_Human1.31233222
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30151685
90MAF_26560356_Chip-Seq_TH1_Human1.29836121
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29163039
92KDM5A_27292631_Chip-Seq_BREAST_Human1.29098971
93ELK1_19687146_ChIP-ChIP_HELA_Human1.28895302
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28065617
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27567750
96MYC_18940864_ChIP-ChIP_HL60_Human1.27222686
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.26266073
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25948090
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.25179227
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24924352
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24269819
102AR_25329375_ChIP-Seq_VCAP_Human1.24146897
103VDR_21846776_ChIP-Seq_THP-1_Human1.23605072
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21922681
105TCF4_23295773_ChIP-Seq_U87_Human1.21628692
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20969020
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.20649017
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20399022
109MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20156411
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19750132
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19256138
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18990023
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17979285
114FOXP3_21729870_ChIP-Seq_TREG_Human1.17834538
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17310879
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.16639625
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.16596280
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15640134
119VDR_23849224_ChIP-Seq_CD4+_Human1.15544955
120ER_23166858_ChIP-Seq_MCF-7_Human1.15501107
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.14834568
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12607722
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.11969129
124SCL_19346495_ChIP-Seq_HPC-7_Human1.11266663
125DCP1A_22483619_ChIP-Seq_HELA_Human1.11056653
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.10984236
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10949777
128MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10307399
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10263067
130SPI1_23547873_ChIP-Seq_NB4_Human1.09617552
131HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09501387
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09335388
133SOX9_26525672_Chip-Seq_HEART_Mouse1.09153322
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08443369
135RUNX1_22412390_ChIP-Seq_EML_Mouse1.07923851
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07610524
137POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07586077
138KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07537170
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07155916
140RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07049852
141MYB_26560356_Chip-Seq_TH1_Human1.06984121
142NANOG_18555785_Chip-Seq_ESCs_Mouse1.06832182
143ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05864765
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05472737
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05205505
146* RUNX2_22187159_ChIP-Seq_PCA_Human1.05124169
147CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04834352
148PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04011307
149BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03762831
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03552326
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03153377
152YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03040998
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02987671
154STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02978816
155TP63_19390658_ChIP-ChIP_HaCaT_Human1.02536209
156GABP_19822575_ChIP-Seq_HepG2_Human1.01994674
157E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01251561
158SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01151704
159TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01083290
160PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00665916
161UTX_26944678_Chip-Seq_JUKART_Human1.00157685
162MYB_26560356_Chip-Seq_TH2_Human1.00113886
163KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00091381
164CHD1_26751641_Chip-Seq_LNCaP_Human0.99558707
165SRF_21415370_ChIP-Seq_HL-1_Mouse0.98624236
166CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97553120
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.96589773
168SOX2_21211035_ChIP-Seq_LN229_Gbm0.96468006
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94257503
170STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94241813
171EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94179964
172CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93976608
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93402203
174EZH2_27294783_Chip-Seq_NPCs_Mouse0.91129923
175TP53_22573176_ChIP-Seq_HFKS_Human0.89669056
176MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89449012
177LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87758979
178BCAT_22108803_ChIP-Seq_LS180_Human0.87127183
179PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86910220
180SMAD4_21741376_ChIP-Seq_EPCs_Human0.85172955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.67795867
2MP0010352_gastrointestinal_tract_polyps2.78995104
3MP0005360_urolithiasis2.50964759
4MP0008058_abnormal_DNA_repair2.38457178
5MP0006292_abnormal_olfactory_placode2.37832568
6MP0003122_maternal_imprinting2.25974844
7MP0001984_abnormal_olfaction2.25965001
8MP0008789_abnormal_olfactory_epithelium2.21818218
9MP0003950_abnormal_plasma_membrane2.17163872
10MP0003693_abnormal_embryo_hatching2.17007278
11MP0005499_abnormal_olfactory_system2.14911710
12MP0005394_taste/olfaction_phenotype2.14911710
13MP0001529_abnormal_vocalization2.14353620
14MP0002139_abnormal_hepatobiliary_system2.06730050
15MP0003566_abnormal_cell_adhesion2.05517357
16MP0002102_abnormal_ear_morphology2.04609418
17MP0003705_abnormal_hypodermis_morpholog2.04093032
18MP0003890_abnormal_embryonic-extraembry2.03756147
19MP0008438_abnormal_cutaneous_collagen1.97064643
20MP0008057_abnormal_DNA_replication1.93930189
21MP0003121_genomic_imprinting1.90230361
22MP0002396_abnormal_hematopoietic_system1.88143663
23MP0003221_abnormal_cardiomyocyte_apopto1.85523542
24MP0003077_abnormal_cell_cycle1.82879468
25MP0003806_abnormal_nucleotide_metabolis1.78540914
26MP0002009_preneoplasia1.74157331
27MP0003880_abnormal_central_pattern1.72752890
28MP0003300_gastrointestinal_ulcer1.72065872
29MP0003718_maternal_effect1.71760312
30MP0008007_abnormal_cellular_replicative1.66806544
31MP0000778_abnormal_nervous_system1.66317848
32MP0003111_abnormal_nucleus_morphology1.66281812
33MP0006072_abnormal_retinal_apoptosis1.66142172
34MP0006054_spinal_hemorrhage1.64034303
35MP0004808_abnormal_hematopoietic_stem1.63879599
36MP0005365_abnormal_bile_salt1.62523162
37MP0003191_abnormal_cellular_cholesterol1.61174142
38MP0009840_abnormal_foam_cell1.60872619
39MP0004264_abnormal_extraembryonic_tissu1.54683671
40MP0002233_abnormal_nose_morphology1.54381772
41MP0002822_catalepsy1.51972519
42MP0002751_abnormal_autonomic_nervous1.51293968
43MP0000631_abnormal_neuroendocrine_gland1.48249694
44MP0005248_abnormal_Harderian_gland1.47432997
45MP0003252_abnormal_bile_duct1.46894066
46MP0004957_abnormal_blastocyst_morpholog1.46335769
47MP0001929_abnormal_gametogenesis1.43470177
48MP0005408_hypopigmentation1.43392382
49MP0000383_abnormal_hair_follicle1.43304786
50MP0004270_analgesia1.41876217
51MP0010094_abnormal_chromosome_stability1.41081757
52MP0000566_synostosis1.40596555
53MP0005023_abnormal_wound_healing1.39461430
54MP0003943_abnormal_hepatobiliary_system1.39381091
55MP0000647_abnormal_sebaceous_gland1.37485175
56MP0009697_abnormal_copulation1.32975789
57MP0004185_abnormal_adipocyte_glucose1.32794103
58MP0001730_embryonic_growth_arrest1.30192281
59MP0002837_dystrophic_cardiac_calcinosis1.27658541
60MP0006035_abnormal_mitochondrial_morpho1.27259307
61MP0008932_abnormal_embryonic_tissue1.24315369
62MP0002210_abnormal_sex_determination1.23982610
63MP0001299_abnormal_eye_distance/1.22297690
64MP0005253_abnormal_eye_physiology1.22271477
65MP0006276_abnormal_autonomic_nervous1.21962338
66MP0002638_abnormal_pupillary_reflex1.21832453
67MP0003787_abnormal_imprinting1.21817165
68MP0005409_darkened_coat_color1.21611076
69MP0005187_abnormal_penis_morphology1.21099456
70MP0003698_abnormal_male_reproductive1.20243843
71MP0000350_abnormal_cell_proliferation1.18479615
72MP0000751_myopathy1.18171684
73MP0010307_abnormal_tumor_latency1.16139249
74MP0005085_abnormal_gallbladder_physiolo1.14925324
75MP0000733_abnormal_muscle_development1.12971849
76MP0003436_decreased_susceptibility_to1.12400754
77MP0005220_abnormal_exocrine_pancreas1.12236286
78MP0002653_abnormal_ependyma_morphology1.12150178
79MP0002234_abnormal_pharynx_morphology1.11577089
80MP0003861_abnormal_nervous_system1.11145308
81MP0009333_abnormal_splenocyte_physiolog1.10789916
82MP0002933_joint_inflammation1.10603177
83MP0002938_white_spotting1.10527269
84MP0003755_abnormal_palate_morphology1.09938356
85MP0002184_abnormal_innervation1.08523487
86MP0003567_abnormal_fetal_cardiomyocyte1.07961861
87MP0002877_abnormal_melanocyte_morpholog1.07863482
88MP0004133_heterotaxia1.07371487
89MP0004215_abnormal_myocardial_fiber1.07317197
90MP0008995_early_reproductive_senescence1.06608512
91MP0000653_abnormal_sex_gland1.06502840
92MP0010678_abnormal_skin_adnexa1.05927499
93MP0009278_abnormal_bone_marrow1.05847840
94MP0005646_abnormal_pituitary_gland1.05814053
95MP0002127_abnormal_cardiovascular_syste1.05449639
96MP0005387_immune_system_phenotype1.05337546
97MP0001790_abnormal_immune_system1.05337546
98MP0002084_abnormal_developmental_patter1.04777789
99MP0003935_abnormal_craniofacial_develop1.04469698
100MP0003136_yellow_coat_color1.04141031
101MP0003984_embryonic_growth_retardation1.04104731
102MP0001915_intracranial_hemorrhage1.03923563
103MP0000955_abnormal_spinal_cord1.03923036
104MP0002088_abnormal_embryonic_growth/wei1.03693988
105MP0005423_abnormal_somatic_nervous1.03519894
106MP0002106_abnormal_muscle_physiology1.02324214
107MP0000598_abnormal_liver_morphology1.01758623
108MP0001672_abnormal_embryogenesis/_devel1.01570639
109MP0005380_embryogenesis_phenotype1.01570639
110MP0010155_abnormal_intestine_physiology0.99919784
111MP0002166_altered_tumor_susceptibility0.99555366
112MP0006138_congestive_heart_failure0.98846928
113MP0001145_abnormal_male_reproductive0.98322772
114MP0005058_abnormal_lysosome_morphology0.98272554
115MP0003656_abnormal_erythrocyte_physiolo0.97540926
116MP0005076_abnormal_cell_differentiation0.96168121
117MP0001879_abnormal_lymphatic_vessel0.96080621
118MP0008961_abnormal_basal_metabolism0.95940855
119MP0009703_decreased_birth_body0.94231540
120MP0005397_hematopoietic_system_phenotyp0.93792081
121MP0001545_abnormal_hematopoietic_system0.93792081
122MP0000015_abnormal_ear_pigmentation0.93541824
123MP0004134_abnormal_chest_morphology0.93522774
124MP0001286_abnormal_eye_development0.93277809
125MP0003119_abnormal_digestive_system0.92814073
126MP0003828_pulmonary_edema0.92102810
127MP0009053_abnormal_anal_canal0.92003096
128MP0001697_abnormal_embryo_size0.91919681
129MP0000858_altered_metastatic_potential0.91872244
130MP0002928_abnormal_bile_duct0.90697940
131MP0004233_abnormal_muscle_weight0.90035990
132MP0002080_prenatal_lethality0.89640912
133MP0000685_abnormal_immune_system0.89113572
134MP0000609_abnormal_liver_physiology0.87931582
135MP0004145_abnormal_muscle_electrophysio0.87611626
136MP0010030_abnormal_orbit_morphology0.87528322
137MP0002019_abnormal_tumor_incidence0.87053899
138MP0004197_abnormal_fetal_growth/weight/0.86894722
139MP0001346_abnormal_lacrimal_gland0.86585814
140MP0002086_abnormal_extraembryonic_tissu0.86472117
141MP0005391_vision/eye_phenotype0.86119007
142MP0001849_ear_inflammation0.85354573
143MP0002269_muscular_atrophy0.85037705
144MP0000490_abnormal_crypts_of0.84917828
145MP0005369_muscle_phenotype0.84515058
146MP0000569_abnormal_digit_pigmentation0.82790664
147MP0004811_abnormal_neuron_physiology0.82502267
148MP0005083_abnormal_biliary_tract0.82187650
149MP0000049_abnormal_middle_ear0.82151631
150MP0002398_abnormal_bone_marrow0.82102550
151MP0000013_abnormal_adipose_tissue0.81468181
152MP0005464_abnormal_platelet_physiology0.80665002
153MP0001666_abnormal_nutrient_absorption0.79409590
154MP0001800_abnormal_humoral_immune0.79104540
155MP0003186_abnormal_redox_activity0.79082512
156MP0010368_abnormal_lymphatic_system0.78820435
157MP0009384_cardiac_valve_regurgitation0.78505985
158MP0004947_skin_inflammation0.78016693
159MP0002085_abnormal_embryonic_tissue0.78000956
160MP0000689_abnormal_spleen_morphology0.76963568
161MP0002405_respiratory_system_inflammati0.76422278
162MP0001243_abnormal_dermal_layer0.76237522
163MP0002128_abnormal_blood_circulation0.75761338
164MP0003937_abnormal_limbs/digits/tail_de0.75717536
165MP0002722_abnormal_immune_system0.75129521
166MP0005171_absent_coat_pigmentation0.74970926
167MP0000313_abnormal_cell_death0.74924290
168MP0002909_abnormal_adrenal_gland0.74828890
169MP0002697_abnormal_eye_size0.74284928
170MP0002161_abnormal_fertility/fecundity0.74035181
171MP0002152_abnormal_brain_morphology0.74014812
172MP0004147_increased_porphyrin_level0.73845891
173MP0001270_distended_abdomen0.73751828
174MP0010630_abnormal_cardiac_muscle0.73089401
175MP0002138_abnormal_hepatobiliary_system0.72813908
176MP0002452_abnormal_antigen_presenting0.72548488
177MP0001293_anophthalmia0.71896592
178MP0002092_abnormal_eye_morphology0.71327963
179MP0000537_abnormal_urethra_morphology0.71292651
180MP0003045_fibrosis0.70450789

Predicted human phenotypes

RankGene SetZ-score
1Rimmed vacuoles (HP:0003805)4.29976180
2Shoulder girdle muscle weakness (HP:0003547)4.14287099
3Abnormality of the hip-girdle musculature (HP:0001445)3.73491090
4Abnormality of the musculature of the pelvis (HP:0001469)3.73491090
5Papillary thyroid carcinoma (HP:0002895)3.35909885
6Medial flaring of the eyebrow (HP:0010747)3.21018198
7Gait imbalance (HP:0002141)3.06368000
8Hypoplasia of the capital femoral epiphysis (HP:0003090)3.02324221
9Congenital primary aphakia (HP:0007707)3.00910533
10Cortical dysplasia (HP:0002539)2.94393829
11Thyroid carcinoma (HP:0002890)2.87346022
12Abnormality of the labia minora (HP:0012880)2.83418013
13Drooling (HP:0002307)2.79705294
14Intrahepatic cholestasis (HP:0001406)2.78811878
15Premature rupture of membranes (HP:0001788)2.77067241
16Nephrogenic diabetes insipidus (HP:0009806)2.75374959
17Abnormality of endocrine pancreas physiology (HP:0012093)2.69015112
18Abnormality of the pancreatic islet cells (HP:0006476)2.69015112
19Cutaneous melanoma (HP:0012056)2.67842656
20Retinal dysplasia (HP:0007973)2.64893961
21Increased mean platelet volume (HP:0011877)2.59355739
22Genital tract atresia (HP:0001827)2.59032789
23Hypoglycemic coma (HP:0001325)2.56774393
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56430699
25Short 4th metacarpal (HP:0010044)2.56430699
26Ulnar bowing (HP:0003031)2.53490050
27Limb-girdle muscle weakness (HP:0003325)2.52784631
28Entropion (HP:0000621)2.51360135
29Abnormality of the fingertips (HP:0001211)2.49642494
30Excessive salivation (HP:0003781)2.46771974
31Neonatal hypoglycemia (HP:0001998)2.44874572
32Intestinal atresia (HP:0011100)2.43128887
33Pancreatic islet-cell hyperplasia (HP:0004510)2.43014092
34Abnormal platelet volume (HP:0011876)2.42772554
35Hyperventilation (HP:0002883)2.39621076
36Osteolytic defects of the hand bones (HP:0009699)2.38402304
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.38402304
38Vaginal atresia (HP:0000148)2.36541758
39Nephronophthisis (HP:0000090)2.36371605
40Pheochromocytoma (HP:0002666)2.34659193
41Thrombocytosis (HP:0001894)2.34522616
42Abnormality of the metopic suture (HP:0005556)2.34348375
43Absent epiphyses (HP:0010577)2.34168161
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.34168161
45Hepatosplenomegaly (HP:0001433)2.33198136
46Oligodactyly (hands) (HP:0001180)2.29520026
47Delayed closure of the anterior fontanelle (HP:0001476)2.27991764
48Exercise-induced muscle cramps (HP:0003710)2.23380982
49Nonimmune hydrops fetalis (HP:0001790)2.21778880
50Macroorchidism (HP:0000053)2.18822526
51Poor coordination (HP:0002370)2.17063879
52Medulloblastoma (HP:0002885)2.16967412
53Amyotrophic lateral sclerosis (HP:0007354)2.15911045
54Hypsarrhythmia (HP:0002521)2.13002830
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.09113097
56Abnormal foot bone ossification (HP:0010675)2.08864152
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.06263245
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06263245
59Abnormality of subcutaneous fat tissue (HP:0001001)2.05267399
60Cervical subluxation (HP:0003308)2.04334597
61Oligodactyly (HP:0012165)2.03773903
62Hepatoblastoma (HP:0002884)2.03773879
63EEG with generalized epileptiform discharges (HP:0011198)2.01348300
64Tubulointerstitial nephritis (HP:0001970)2.01075206
65True hermaphroditism (HP:0010459)2.00268307
66Colon cancer (HP:0003003)1.99665900
67Hyperinsulinemic hypoglycemia (HP:0000825)1.99217521
68Chronic hepatic failure (HP:0100626)1.98898393
69Cystic hygroma (HP:0000476)1.97843160
70Limb-girdle muscle atrophy (HP:0003797)1.97644929
71Neuroendocrine neoplasm (HP:0100634)1.96812351
72Abnormality of the corticospinal tract (HP:0002492)1.95302059
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95002867
74Abnormality of the 4th metacarpal (HP:0010012)1.94608857
75Facial hemangioma (HP:0000329)1.93404250
76Prominent metopic ridge (HP:0005487)1.92891040
77Abnormality of the peritoneum (HP:0002585)1.92128639
78Postnatal microcephaly (HP:0005484)1.90927780
79Abnormality of the calcaneus (HP:0008364)1.90250712
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90038567
81Epileptiform EEG discharges (HP:0011182)1.89581198
82Recurrent viral infections (HP:0004429)1.89131624
83Lissencephaly (HP:0001339)1.88856611
84Abnormality of the renal medulla (HP:0100957)1.88269255
85Pancreatic cysts (HP:0001737)1.88084891
86Right ventricular cardiomyopathy (HP:0011663)1.87438785
87Gonadotropin excess (HP:0000837)1.87027074
88Urinary urgency (HP:0000012)1.86710970
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.86645173
90Progressive inability to walk (HP:0002505)1.86477305
91Median cleft lip (HP:0000161)1.84744363
92Hyporeflexia of lower limbs (HP:0002600)1.84677933
93Pancreatic fibrosis (HP:0100732)1.83544179
94Sparse lateral eyebrow (HP:0005338)1.81797869
95Insulin resistance (HP:0000855)1.81548770
96Occipital encephalocele (HP:0002085)1.81499244
97Fat malabsorption (HP:0002630)1.80342551
98Steatorrhea (HP:0002570)1.80305079
99Deep venous thrombosis (HP:0002625)1.79084835
100Postaxial hand polydactyly (HP:0001162)1.79050308
101Hypobetalipoproteinemia (HP:0003563)1.78964180
102Myocardial infarction (HP:0001658)1.78908209
103IgM deficiency (HP:0002850)1.78758643
104Disproportionate tall stature (HP:0001519)1.77754029
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.77429631
106Proximal amyotrophy (HP:0007126)1.75925673
107Molar tooth sign on MRI (HP:0002419)1.75600676
108Abnormality of midbrain morphology (HP:0002418)1.75600676
109Decreased testicular size (HP:0008734)1.75262024
110Cerebral hypomyelination (HP:0006808)1.74935994
111Absent speech (HP:0001344)1.74683180
112Submucous cleft hard palate (HP:0000176)1.74591098
113Specific learning disability (HP:0001328)1.72970287
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.72281664
115Abnormality of abdominal situs (HP:0011620)1.72005506
116Abdominal situs inversus (HP:0003363)1.72005506
117Supernumerary spleens (HP:0009799)1.71850319
118Long eyelashes (HP:0000527)1.71170903
119Abnormal hair whorl (HP:0010721)1.71141224
120Metaphyseal cupping (HP:0003021)1.70643787
121Rhinitis (HP:0012384)1.69697868
122T lymphocytopenia (HP:0005403)1.69363910
123Hypoplastic ischia (HP:0003175)1.69340221
124Abnormality of the calf musculature (HP:0001430)1.69113789
125IgA deficiency (HP:0002720)1.68979445
126Neoplasm of the oral cavity (HP:0100649)1.68904782
127Ascites (HP:0001541)1.68831638
128Cellulitis (HP:0100658)1.67008584
129Broad foot (HP:0001769)1.66811343
130Broad-based gait (HP:0002136)1.66546304
131Abnormality of methionine metabolism (HP:0010901)1.65333368
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65078351
133Abnormality of lateral ventricle (HP:0030047)1.65025671
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.64771628
135Postaxial foot polydactyly (HP:0001830)1.64599924
136Chondrocalcinosis (HP:0000934)1.64023237
137Abnormality of fatty-acid metabolism (HP:0004359)1.63772236
138Depressed nasal tip (HP:0000437)1.63404663
139Impaired vibration sensation in the lower limbs (HP:0002166)1.62858436
140Hypoglycemic seizures (HP:0002173)1.62755171
141Muscular hypotonia of the trunk (HP:0008936)1.62683777
142Preaxial hand polydactyly (HP:0001177)1.61644657
143Failure to thrive in infancy (HP:0001531)1.61521757
144Neoplasm of the adrenal cortex (HP:0100641)1.61211589
145Abnormality of oral frenula (HP:0000190)1.60922779
146Xanthomatosis (HP:0000991)1.60490234
147Micropenis (HP:0000054)1.58813995
148Abnormal sex determination (HP:0012244)1.58179905
149Sex reversal (HP:0012245)1.58179905
150Polyphagia (HP:0002591)1.57911399
151Hemiparesis (HP:0001269)1.57795325
152Abnormal respiratory motile cilium physiology (HP:0012261)1.57730409
153Calf muscle hypertrophy (HP:0008981)1.57415902
154Hyperammonemia (HP:0001987)1.57056782
155Upper motor neuron abnormality (HP:0002127)1.56818665
156Abnormality of the intrinsic pathway (HP:0010989)1.56399989
157Upper limb muscle weakness (HP:0003484)1.56090755
158Abnormal pancreas size (HP:0012094)1.55944171
159Protruding tongue (HP:0010808)1.55923121
160Gastroesophageal reflux (HP:0002020)1.55620888
161Scrotal hypoplasia (HP:0000046)1.55271062
162Narrow forehead (HP:0000341)1.55253653
163Generalized aminoaciduria (HP:0002909)1.55213113
164Aplastic anemia (HP:0001915)1.54345420
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.54084808
166Hypoplasia of the brainstem (HP:0002365)1.54084808
167Volvulus (HP:0002580)1.53982457
168Abnormality of monocarboxylic acid metabolism (HP:0010996)1.53171756
169Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.52943395
170Peritonitis (HP:0002586)1.52844382
171Shallow orbits (HP:0000586)1.52422011
172Abnormal enzyme/coenzyme activity (HP:0012379)1.52369679
173Abnormality of T cell number (HP:0011839)1.52351326
174Blue sclerae (HP:0000592)1.52342116
175Poikiloderma (HP:0001029)1.52109354
176Hypercholesterolemia (HP:0003124)1.51523334
177Limited elbow extension (HP:0001377)1.51257318
178Acute myeloid leukemia (HP:0004808)1.51035457
179Elevated erythrocyte sedimentation rate (HP:0003565)1.50683250
180Abnormality of iron homeostasis (HP:0011031)1.49559572
181Spontaneous hematomas (HP:0007420)1.49090236
182Deviation of the thumb (HP:0009603)1.49017536
183High pitched voice (HP:0001620)1.49008190
184Glucose intolerance (HP:0000833)1.48295312
185Stridor (HP:0010307)1.47242453
186Elevated alkaline phosphatase (HP:0003155)1.47198692
187Spastic diplegia (HP:0001264)1.45437771
188Ependymoma (HP:0002888)1.44985061
189Interstitial pulmonary disease (HP:0006530)1.44140021
190Abnormality of alkaline phosphatase activity (HP:0004379)1.43645811
191Abnormality of the umbilical cord (HP:0010881)1.43184599
192Rhabdomyosarcoma (HP:0002859)1.43082698
193Hepatocellular carcinoma (HP:0001402)1.43029249
194Pelvic girdle muscle weakness (HP:0003749)1.41944415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA33.42707952
2TRIM283.15741862
3MAP3K43.15058586
4PNCK2.97847091
5TRIB32.93813991
6TNIK2.88463215
7CASK2.80446992
8MARK12.70356899
9STK102.61940268
10MAP4K12.40948069
11MAP2K72.28247009
12EPHB12.19445868
13WEE12.18955464
14NUAK12.15238422
15WNK31.91967239
16BCR1.89996785
17TSSK61.84349846
18STK38L1.83179786
19EIF2AK31.81594224
20PASK1.80277537
21CSNK1G21.79627742
22DYRK21.77103989
23MAP2K41.75561532
24TTN1.72768270
25MAP3K101.68769626
26TYK21.62040506
27BUB11.56788816
28PIK3CA1.49232865
29PLK41.48631601
30CDC71.44740900
31CDK121.43779783
32FGFR41.43714840
33NEK91.42806490
34ATR1.40596728
35PINK11.35006361
36TESK21.34234917
37DYRK31.33546803
38PKN21.32836657
39MET1.32428968
40PHKG21.31095972
41PHKG11.31095972
42MAP2K31.30622572
43MAP3K81.29280443
44YES11.29139807
45CSF1R1.28164060
46NLK1.27822068
47CAMK1D1.27720694
48MKNK11.27609989
49MST41.27417868
50PLK21.26988908
51CLK11.26737640
52EPHA41.23551079
53MKNK21.19789404
54PTK61.16245226
55BRD41.15976752
56LRRK21.15563438
57STK391.13036988
58FLT31.11086340
59CDK71.10634749
60NEK61.09087797
61RPS6KB21.08352894
62SIK11.07814077
63OBSCN1.07639095
64BMPR1B1.06700104
65STK41.05482314
66MAP3K51.04750643
67CDK81.04724838
68BRSK21.02244004
69TGFBR11.00807035
70CDK41.00021485
71IRAK10.99918355
72BTK0.99677275
73DMPK0.94719814
74CCNB10.94367552
75LATS10.94115386
76ILK0.93987659
77JAK30.93499100
78FRK0.92992835
79PAK40.92490269
80MAP3K120.92279790
81TRPM70.91265815
82NEK20.89360419
83EEF2K0.88975683
84LIMK10.88465151
85MELK0.87468845
86PIM10.85601259
87ERBB30.85551648
88ZAK0.85270195
89KDR0.82114839
90TLK10.81483320
91MAP3K60.81042767
92CDK190.79233116
93PAK30.79000971
94KSR10.78250585
95MAPK130.77332486
96MAP4K20.77145312
97STK30.76455865
98MAPK110.76373385
99ITK0.74973028
100ATM0.74767297
101NTRK20.74523256
102CDK60.73972061
103TEC0.72785645
104MTOR0.71200144
105AURKB0.70383824
106TAOK30.70156775
107FGFR10.68967630
108TTK0.68936976
109PLK30.68897732
110DYRK1A0.68873765
111CSNK1A1L0.68847442
112PLK10.68247725
113EIF2AK20.68134373
114TAOK20.67393345
115CAMK1G0.66803086
116KIT0.66584079
117NEK10.66572167
118PDGFRB0.66180316
119PBK0.65863036
120PRKAA10.63134215
121AKT30.62630625
122FGFR20.62193768
123PAK20.62115544
124CDK90.61753101
125MAPKAPK20.61436498
126BRSK10.59611363
127PTK20.58783018
128RPS6KA40.58136238
129MAP2K20.57591927
130CDK30.57076391
131SRPK10.56916086
132TXK0.56870591
133RPS6KA50.55622124
134LMTK20.54844413
135DYRK1B0.53439401
136PDGFRA0.53405612
137PIK3CG0.52552448
138PKN10.51939397
139GSK3A0.51017918
140MARK30.49696019
141LCK0.49271860
142CHEK10.48949009
143CAMKK20.48911678
144ZAP700.47369185
145VRK10.47324618
146CSNK1D0.46990829
147PAK10.46102016
148PRKCH0.45690969
149TAOK10.45281574
150IRAK30.44849732
151PRKACB0.44299252
152MAP3K70.43109486
153SCYL20.42669769
154IKBKB0.42595989
155CAMK40.42203289
156CSNK1G30.41971419
157CSNK1G10.41314997
158RET0.41025518
159JAK10.40963488
160SGK20.39577616
161CDK10.39333833
162PRKCE0.38632308
163CSNK1E0.37514683
164UHMK10.36502822
165CDK20.36161031
166EIF2AK10.33117913
167MAPK150.33000666
168PRKG10.31972837
169EGFR0.30636763
170ACVR1B0.30416690
171AURKA0.29910954

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.87807555
2Mismatch repair_Homo sapiens_hsa034302.34048721
3One carbon pool by folate_Homo sapiens_hsa006702.30104057
4Basal transcription factors_Homo sapiens_hsa030222.23536587
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98220898
6Circadian rhythm_Homo sapiens_hsa047101.95777891
7Regulation of autophagy_Homo sapiens_hsa041401.93942206
8Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.78288545
9Cell cycle_Homo sapiens_hsa041101.74432808
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73304421
11Steroid biosynthesis_Homo sapiens_hsa001001.70590415
12Nitrogen metabolism_Homo sapiens_hsa009101.55570646
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53195678
14Selenocompound metabolism_Homo sapiens_hsa004501.52085943
15Non-homologous end-joining_Homo sapiens_hsa034501.50364228
16Base excision repair_Homo sapiens_hsa034101.49276387
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48729631
18RNA transport_Homo sapiens_hsa030131.45767249
19Fatty acid elongation_Homo sapiens_hsa000621.44703504
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39089112
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37084003
22Fanconi anemia pathway_Homo sapiens_hsa034601.36715643
23Systemic lupus erythematosus_Homo sapiens_hsa053221.32499967
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.32290834
25Viral carcinogenesis_Homo sapiens_hsa052031.29527559
26Spliceosome_Homo sapiens_hsa030401.28050978
27Butanoate metabolism_Homo sapiens_hsa006501.26701238
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26683712
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26531784
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24586593
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24199489
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21668264
33Protein export_Homo sapiens_hsa030601.21263916
34Folate biosynthesis_Homo sapiens_hsa007901.20140406
35Homologous recombination_Homo sapiens_hsa034401.19062802
36Oocyte meiosis_Homo sapiens_hsa041141.16845331
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15969245
38Fatty acid degradation_Homo sapiens_hsa000711.14559110
39Lysine degradation_Homo sapiens_hsa003101.13752853
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12518015
41RNA polymerase_Homo sapiens_hsa030201.12300332
42Nicotine addiction_Homo sapiens_hsa050331.11753399
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07372189
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07285752
45Nucleotide excision repair_Homo sapiens_hsa034201.06609244
46Sulfur metabolism_Homo sapiens_hsa009201.05723876
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.02359210
48Tryptophan metabolism_Homo sapiens_hsa003801.01995803
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00512924
50Peroxisome_Homo sapiens_hsa041460.99428947
51Small cell lung cancer_Homo sapiens_hsa052220.96901258
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96620668
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94524918
54Leishmaniasis_Homo sapiens_hsa051400.94069488
55MicroRNAs in cancer_Homo sapiens_hsa052060.92640598
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.92373357
57Legionellosis_Homo sapiens_hsa051340.92316868
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91050730
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90644775
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90389265
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89699347
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89342091
63Fatty acid metabolism_Homo sapiens_hsa012120.86732853
64Staphylococcus aureus infection_Homo sapiens_hsa051500.86256401
65Herpes simplex infection_Homo sapiens_hsa051680.85563294
66Pyrimidine metabolism_Homo sapiens_hsa002400.84331325
67Dorso-ventral axis formation_Homo sapiens_hsa043200.84263816
68TGF-beta signaling pathway_Homo sapiens_hsa043500.84262896
69Phototransduction_Homo sapiens_hsa047440.83792045
70Measles_Homo sapiens_hsa051620.83612594
71p53 signaling pathway_Homo sapiens_hsa041150.82745557
72Antigen processing and presentation_Homo sapiens_hsa046120.81792655
73Viral myocarditis_Homo sapiens_hsa054160.81685124
74Chronic myeloid leukemia_Homo sapiens_hsa052200.81047258
75Complement and coagulation cascades_Homo sapiens_hsa046100.80910142
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.80909363
77Hippo signaling pathway_Homo sapiens_hsa043900.80537059
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80448654
79Axon guidance_Homo sapiens_hsa043600.80304087
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78822804
81Carbon metabolism_Homo sapiens_hsa012000.78319263
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.77824970
83Propanoate metabolism_Homo sapiens_hsa006400.76729813
84Pentose phosphate pathway_Homo sapiens_hsa000300.76109977
85Long-term depression_Homo sapiens_hsa047300.73936584
86HTLV-I infection_Homo sapiens_hsa051660.73821559
87Epstein-Barr virus infection_Homo sapiens_hsa051690.73470194
88Type II diabetes mellitus_Homo sapiens_hsa049300.72249480
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.72061924
90Biosynthesis of amino acids_Homo sapiens_hsa012300.71450977
91Arginine and proline metabolism_Homo sapiens_hsa003300.69743929
92AMPK signaling pathway_Homo sapiens_hsa041520.69282049
93Taste transduction_Homo sapiens_hsa047420.68539640
94Pyruvate metabolism_Homo sapiens_hsa006200.67488900
95Notch signaling pathway_Homo sapiens_hsa043300.67226348
96Glutathione metabolism_Homo sapiens_hsa004800.64826953
97Proteoglycans in cancer_Homo sapiens_hsa052050.63808410
98mTOR signaling pathway_Homo sapiens_hsa041500.63564079
99RNA degradation_Homo sapiens_hsa030180.63270947
100Caffeine metabolism_Homo sapiens_hsa002320.62954350
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62844803
102Basal cell carcinoma_Homo sapiens_hsa052170.62683410
103mRNA surveillance pathway_Homo sapiens_hsa030150.62558370
104Prostate cancer_Homo sapiens_hsa052150.61684119
105PPAR signaling pathway_Homo sapiens_hsa033200.61362812
106Apoptosis_Homo sapiens_hsa042100.59650860
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59612668
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59035506
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.58589622
110Hedgehog signaling pathway_Homo sapiens_hsa043400.57915400
111Shigellosis_Homo sapiens_hsa051310.56971331
112Ovarian steroidogenesis_Homo sapiens_hsa049130.56660108
113FoxO signaling pathway_Homo sapiens_hsa040680.56388285
114Histidine metabolism_Homo sapiens_hsa003400.56059218
115ABC transporters_Homo sapiens_hsa020100.55643386
116Adherens junction_Homo sapiens_hsa045200.54630542
117Toxoplasmosis_Homo sapiens_hsa051450.54267584
118Gap junction_Homo sapiens_hsa045400.53739756
119Sulfur relay system_Homo sapiens_hsa041220.53734074
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.53004069
121Hepatitis B_Homo sapiens_hsa051610.52681440
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.51950886
123Starch and sucrose metabolism_Homo sapiens_hsa005000.50910332
124Wnt signaling pathway_Homo sapiens_hsa043100.49056220
125Collecting duct acid secretion_Homo sapiens_hsa049660.48563773
126Pancreatic cancer_Homo sapiens_hsa052120.48539955
127N-Glycan biosynthesis_Homo sapiens_hsa005100.48267433
128Colorectal cancer_Homo sapiens_hsa052100.48223974
129Insulin resistance_Homo sapiens_hsa049310.48185305
130Purine metabolism_Homo sapiens_hsa002300.46885521
131Retinol metabolism_Homo sapiens_hsa008300.46850890
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46443727
133Vibrio cholerae infection_Homo sapiens_hsa051100.46289456
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44867830
135Non-small cell lung cancer_Homo sapiens_hsa052230.44767443
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44219306
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42796250
138GABAergic synapse_Homo sapiens_hsa047270.41623013
139B cell receptor signaling pathway_Homo sapiens_hsa046620.41564294
140Bladder cancer_Homo sapiens_hsa052190.41420301
141Tyrosine metabolism_Homo sapiens_hsa003500.41012491
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40854380
143Cocaine addiction_Homo sapiens_hsa050300.40687980
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40416209
145Endometrial cancer_Homo sapiens_hsa052130.40215432
146beta-Alanine metabolism_Homo sapiens_hsa004100.39557138
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39520592
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39200748
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37985474
150Inositol phosphate metabolism_Homo sapiens_hsa005620.35359536
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32825378
152Dilated cardiomyopathy_Homo sapiens_hsa054140.32374654
153Insulin secretion_Homo sapiens_hsa049110.31637487

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