TSTD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.01962201
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.76476022
3ATP synthesis coupled proton transport (GO:0015986)5.53875434
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53875434
5respiratory electron transport chain (GO:0022904)5.34113372
6electron transport chain (GO:0022900)5.16171062
7aldehyde catabolic process (GO:0046185)4.19843467
8inositol phosphate catabolic process (GO:0071545)3.99138499
9protein complex biogenesis (GO:0070271)3.91085700
10peptidyl-histidine modification (GO:0018202)3.90860985
11branched-chain amino acid catabolic process (GO:0009083)3.83003494
12tryptophan catabolic process (GO:0006569)3.81693028
13indole-containing compound catabolic process (GO:0042436)3.81693028
14indolalkylamine catabolic process (GO:0046218)3.81693028
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.78669236
16NADH dehydrogenase complex assembly (GO:0010257)3.78669236
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78669236
18water-soluble vitamin biosynthetic process (GO:0042364)3.74911187
19mannosylation (GO:0097502)3.73778740
20aromatic amino acid family catabolic process (GO:0009074)3.72146171
21cofactor catabolic process (GO:0051187)3.71951654
22phosphorylated carbohydrate dephosphorylation (GO:0046838)3.63413829
23inositol phosphate dephosphorylation (GO:0046855)3.63413829
24cytochrome complex assembly (GO:0017004)3.62111845
25lactate metabolic process (GO:0006089)3.62027691
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.55530647
27L-phenylalanine catabolic process (GO:0006559)3.55530647
28mitochondrial respiratory chain complex assembly (GO:0033108)3.51091537
29tryptophan metabolic process (GO:0006568)3.47220259
30NAD biosynthetic process (GO:0009435)3.46485269
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.45745589
32L-phenylalanine metabolic process (GO:0006558)3.45745589
33proteasome assembly (GO:0043248)3.45667116
34cellular biogenic amine catabolic process (GO:0042402)3.42795109
35amine catabolic process (GO:0009310)3.42795109
36intraciliary transport (GO:0042073)3.42224770
37protein-cofactor linkage (GO:0018065)3.39101651
38positive regulation of protein homodimerization activity (GO:0090073)3.34382811
39DNA double-strand break processing (GO:0000729)3.33946866
40auditory receptor cell differentiation (GO:0042491)3.32198826
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31885643
42platelet dense granule organization (GO:0060155)3.31553771
43respiratory chain complex IV assembly (GO:0008535)3.31518131
44preassembly of GPI anchor in ER membrane (GO:0016254)3.29420645
45chaperone-mediated protein transport (GO:0072321)3.28517700
46regulation of cilium movement (GO:0003352)3.26785459
47signal peptide processing (GO:0006465)3.22041243
48GPI anchor biosynthetic process (GO:0006506)3.18400184
49epithelial cilium movement (GO:0003351)3.17444235
50protein localization to cilium (GO:0061512)3.17387609
51negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15850260
52coenzyme catabolic process (GO:0009109)3.15750787
53protein neddylation (GO:0045116)3.15261649
54dopamine transport (GO:0015872)3.14716015
55oxidative phosphorylation (GO:0006119)3.12858579
56NAD metabolic process (GO:0019674)3.12251803
57superoxide anion generation (GO:0042554)3.11731371
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11444412
59C-terminal protein lipidation (GO:0006501)3.10113567
60hydrogen ion transmembrane transport (GO:1902600)3.09813119
61polyol catabolic process (GO:0046174)3.09778058
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08231609
63ATP biosynthetic process (GO:0006754)3.05808984
64kynurenine metabolic process (GO:0070189)3.05561226
65rRNA modification (GO:0000154)3.04937641
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03947471
67GPI anchor metabolic process (GO:0006505)3.03625619
68synapsis (GO:0007129)3.02630277
69hydrogen peroxide biosynthetic process (GO:0050665)2.98490774
70proton transport (GO:0015992)2.97496243
71hydrogen transport (GO:0006818)2.93952316
72indolalkylamine metabolic process (GO:0006586)2.93253168
73C-terminal protein amino acid modification (GO:0018410)2.91938196
74aerobic respiration (GO:0009060)2.88908911
75regulation of mitochondrial translation (GO:0070129)2.87176327
76aromatic amino acid family metabolic process (GO:0009072)2.85767762
77purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85249680
78branched-chain amino acid metabolic process (GO:0009081)2.84832613
79NADH metabolic process (GO:0006734)2.83633302
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.81709625
81negative regulation of execution phase of apoptosis (GO:1900118)2.80605200
82bile acid biosynthetic process (GO:0006699)2.80301586
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79696662
84cellular ketone body metabolic process (GO:0046950)2.78395706
85opsonization (GO:0008228)2.78084776
86intracellular protein transmembrane import (GO:0044743)2.77750139
87lipid particle organization (GO:0034389)2.77616690
88regulation of type B pancreatic cell apoptotic process (GO:2000674)2.77001218
89pseudouridine synthesis (GO:0001522)2.75931032
90glyoxylate metabolic process (GO:0046487)2.75621468
91nicotinamide nucleotide biosynthetic process (GO:0019359)2.74720238
92pyridine nucleotide biosynthetic process (GO:0019363)2.74720238
93replication fork processing (GO:0031297)2.73818708
94positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.73149704
95negative regulation of neurological system process (GO:0031645)2.73058243
96phagosome maturation (GO:0090382)2.72738489
97regulation of cholesterol esterification (GO:0010872)2.72609194
98high-density lipoprotein particle remodeling (GO:0034375)2.71703660
99DNA deamination (GO:0045006)2.71492929
100nucleotide transmembrane transport (GO:1901679)2.69480651
101peroxisome fission (GO:0016559)2.69417375
102insulin secretion (GO:0030073)2.69169397
103presynaptic membrane assembly (GO:0097105)2.67489062
104tricarboxylic acid cycle (GO:0006099)2.67382375
105amino acid salvage (GO:0043102)2.67107582
106L-methionine salvage (GO:0071267)2.67107582
107L-methionine biosynthetic process (GO:0071265)2.67107582
108cellular response to zinc ion (GO:0071294)2.67031726
109S-adenosylmethionine metabolic process (GO:0046500)2.66764089
110inner mitochondrial membrane organization (GO:0007007)2.66584473
111protein deneddylation (GO:0000338)2.65565695
112dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.65058778
113prenylation (GO:0097354)2.63790128
114protein prenylation (GO:0018342)2.63790128
115regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63629180
116energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61026773
117ATP hydrolysis coupled proton transport (GO:0015991)2.61026773
118cullin deneddylation (GO:0010388)2.60810102
119regulation of cellular amino acid metabolic process (GO:0006521)2.59994402
120reactive oxygen species biosynthetic process (GO:1903409)2.59840765
121cilium morphogenesis (GO:0060271)2.58961683
122rRNA methylation (GO:0031167)2.58820048
123aggressive behavior (GO:0002118)2.58241988
124cellular respiration (GO:0045333)2.58082563
125neuron cell-cell adhesion (GO:0007158)2.55353075
126glycolipid biosynthetic process (GO:0009247)2.54459512
127arginine metabolic process (GO:0006525)2.53965414
128regulation of fibrinolysis (GO:0051917)2.53510959
129histone H2A acetylation (GO:0043968)2.52640598
130RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52148482
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52148482
132nitrogen cycle metabolic process (GO:0071941)2.50748159
133axoneme assembly (GO:0035082)2.49960231
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49608588
135isotype switching (GO:0045190)2.49608588
136somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49608588
137positive regulation of glycolytic process (GO:0045821)2.49502671
138oxaloacetate metabolic process (GO:0006107)2.48710122
139regulation of hexokinase activity (GO:1903299)2.48384689
140regulation of glucokinase activity (GO:0033131)2.48384689
141termination of RNA polymerase III transcription (GO:0006386)2.47939444
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.47939444
143peptidyl-glutamic acid carboxylation (GO:0017187)2.47214912
144protein carboxylation (GO:0018214)2.47214912
145succinate metabolic process (GO:0006105)2.47177257
146positive regulation of mitochondrial fission (GO:0090141)2.46851513
147uronic acid metabolic process (GO:0006063)2.46678058
148glucuronate metabolic process (GO:0019585)2.46678058
149opioid receptor signaling pathway (GO:0038003)2.45772921
150tyrosine metabolic process (GO:0006570)2.45303097
151pyrimidine nucleobase catabolic process (GO:0006208)2.45163623
152urea metabolic process (GO:0019627)2.44935118
153urea cycle (GO:0000050)2.44935118
154mitochondrial transport (GO:0006839)2.43695263
155regulation of acyl-CoA biosynthetic process (GO:0050812)2.43586478
156neuron fate determination (GO:0048664)2.43036004
157regulation of cellular respiration (GO:0043457)2.42797562
158purine ribonucleotide transport (GO:0015868)2.42062209
159response to pheromone (GO:0019236)2.41248994
160somatic hypermutation of immunoglobulin genes (GO:0016446)2.41044526
161somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41044526
162indole-containing compound metabolic process (GO:0042430)2.40810305
163plasma lipoprotein particle remodeling (GO:0034369)2.40438061
164protein-lipid complex remodeling (GO:0034368)2.40438061
165macromolecular complex remodeling (GO:0034367)2.40438061
166protein peptidyl-prolyl isomerization (GO:0000413)2.39332152
167nucleoside triphosphate biosynthetic process (GO:0009142)2.38445063
168regulation of triglyceride catabolic process (GO:0010896)2.38183154
169ubiquinone biosynthetic process (GO:0006744)2.38024565
170serotonin receptor signaling pathway (GO:0007210)2.37031927
171ketone body metabolic process (GO:1902224)2.36397242
172cellular response to superoxide (GO:0071451)2.36362616
173cellular response to oxygen radical (GO:0071450)2.36362616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.10836325
2GBX2_23144817_ChIP-Seq_PC3_Human3.67052731
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31556078
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14982228
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00630486
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.98852674
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.97197701
8ZNF274_21170338_ChIP-Seq_K562_Hela2.76554966
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75779239
10TAF15_26573619_Chip-Seq_HEK293_Human2.70537520
11VDR_22108803_ChIP-Seq_LS180_Human2.63418007
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54864100
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50428770
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.38439124
15EZH2_22144423_ChIP-Seq_EOC_Human2.32155056
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29634142
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19740048
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.17544835
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16190224
20VDR_23849224_ChIP-Seq_CD4+_Human2.07126847
21EWS_26573619_Chip-Seq_HEK293_Human2.02258797
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97420840
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.91432860
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.90795914
25P300_19829295_ChIP-Seq_ESCs_Human1.89647817
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79819776
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72857020
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.70493384
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70226295
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69212715
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66873179
32ER_23166858_ChIP-Seq_MCF-7_Human1.66436719
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66208848
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.65326434
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64034772
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63160730
37HTT_18923047_ChIP-ChIP_STHdh_Human1.61783785
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61461909
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60774989
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.60704969
41MYC_18940864_ChIP-ChIP_HL60_Human1.56931878
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56102654
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55130744
44TP53_22573176_ChIP-Seq_HFKS_Human1.54950742
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.54462818
46STAT3_18555785_Chip-Seq_ESCs_Mouse1.54234940
47P53_22387025_ChIP-Seq_ESCs_Mouse1.53243013
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53141126
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52457433
50FOXP3_21729870_ChIP-Seq_TREG_Human1.52004424
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51118969
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50710888
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50676047
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49818338
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.48837583
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47103505
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.46938298
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.45972231
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.45281629
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.43056717
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42865593
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42667867
63FUS_26573619_Chip-Seq_HEK293_Human1.42290953
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.41988478
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41276027
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41059402
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41035981
68P300_18555785_Chip-Seq_ESCs_Mouse1.40465309
69IGF1R_20145208_ChIP-Seq_DFB_Human1.40160736
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38876374
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.37022284
72IRF1_19129219_ChIP-ChIP_H3396_Human1.36653853
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35451241
74DCP1A_22483619_ChIP-Seq_HELA_Human1.34470673
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.34377785
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33431784
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32387328
78GABP_19822575_ChIP-Seq_HepG2_Human1.31953182
79SMAD4_21799915_ChIP-Seq_A2780_Human1.30414128
80JUN_21703547_ChIP-Seq_K562_Human1.28697817
81PU1_27457419_Chip-Seq_LIVER_Mouse1.27501611
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.27493231
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25991815
84SMAD1_18555785_Chip-Seq_ESCs_Mouse1.25403304
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25030870
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.24676861
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.23688508
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22869999
89ZFX_18555785_Chip-Seq_ESCs_Mouse1.22326181
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.18079341
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17963240
92CTCF_18555785_Chip-Seq_ESCs_Mouse1.17943481
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17805315
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17411889
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16552820
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16221047
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.16221047
98REST_21632747_ChIP-Seq_MESCs_Mouse1.15555797
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15358814
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14371889
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.13925668
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.13868905
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13509423
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13471551
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13387096
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.13207355
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13167312
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.12954015
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12700547
110AR_20517297_ChIP-Seq_VCAP_Human1.12682843
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10949741
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10596006
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10514284
114CBP_20019798_ChIP-Seq_JUKART_Human1.10514284
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10226809
116AR_25329375_ChIP-Seq_VCAP_Human1.08385478
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08349086
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07973153
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07971181
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07320146
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05921440
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05009444
123E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02317098
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02241434
125NCOR_22424771_ChIP-Seq_293T_Human1.00847350
126BCAT_22108803_ChIP-Seq_LS180_Human1.00271681
127ELK1_19687146_ChIP-ChIP_HELA_Human0.99638926
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.99090476
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.98892230
130SOX2_19829295_ChIP-Seq_ESCs_Human0.97872712
131NANOG_19829295_ChIP-Seq_ESCs_Human0.97872712
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97300005
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97144200
134TCF4_22108803_ChIP-Seq_LS180_Human0.96162105
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95268448
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94719391
137GATA3_21878914_ChIP-Seq_MCF-7_Human0.94133659
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93115191
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.93034663
140KDM2B_26808549_Chip-Seq_REH_Human0.92865596
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92803410
142E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89287449
143PHF8_20622853_ChIP-Seq_HELA_Human0.87954550
144CDX2_22108803_ChIP-Seq_LS180_Human0.87894430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.18702876
2MP0005360_urolithiasis4.02518405
3MP0003880_abnormal_central_pattern3.79174280
4MP0003806_abnormal_nucleotide_metabolis3.75004356
5MP0005085_abnormal_gallbladder_physiolo3.41432742
6MP0006072_abnormal_retinal_apoptosis3.20339931
7MP0003195_calcinosis2.88821499
8MP0009697_abnormal_copulation2.68153725
9MP0005365_abnormal_bile_salt2.60340212
10MP0008875_abnormal_xenobiotic_pharmacok2.56358173
11MP0006276_abnormal_autonomic_nervous2.55658255
12MP0002736_abnormal_nociception_after2.45869089
13MP0002938_white_spotting2.29657847
14MP0001968_abnormal_touch/_nociception2.24513741
15MP0001529_abnormal_vocalization2.14462051
16MP0002735_abnormal_chemical_nociception2.12270937
17MP0002876_abnormal_thyroid_physiology2.11503223
18MP0005253_abnormal_eye_physiology2.10017351
19MP0008058_abnormal_DNA_repair2.06971673
20MP0006036_abnormal_mitochondrial_physio2.06389685
21MP0006035_abnormal_mitochondrial_morpho1.99351091
22MP0003787_abnormal_imprinting1.96316966
23MP0003186_abnormal_redox_activity1.83470911
24MP0003122_maternal_imprinting1.79668796
25MP0008789_abnormal_olfactory_epithelium1.79112155
26MP0002837_dystrophic_cardiac_calcinosis1.73981086
27MP0008877_abnormal_DNA_methylation1.73066160
28MP0001905_abnormal_dopamine_level1.67593195
29MP0003724_increased_susceptibility_to1.67212557
30MP0009046_muscle_twitch1.66011199
31MP0009780_abnormal_chondrocyte_physiolo1.62250480
32MP0001764_abnormal_homeostasis1.60874109
33MP0001835_abnormal_antigen_presentation1.60555165
34MP0009745_abnormal_behavioral_response1.60187474
35MP0004147_increased_porphyrin_level1.57505880
36MP0001984_abnormal_olfaction1.57358545
37MP0005332_abnormal_amino_acid1.56934421
38MP0010329_abnormal_lipoprotein_level1.55209453
39MP0001485_abnormal_pinna_reflex1.54457203
40MP0005187_abnormal_penis_morphology1.54045743
41MP0005367_renal/urinary_system_phenotyp1.54022236
42MP0000516_abnormal_urinary_system1.54022236
43MP0002272_abnormal_nervous_system1.51133120
44MP0004142_abnormal_muscle_tone1.49038580
45MP0002064_seizures1.48670144
46MP0005083_abnormal_biliary_tract1.48207197
47MP0003646_muscle_fatigue1.47529375
48MP0010234_abnormal_vibrissa_follicle1.45622394
49MP0004215_abnormal_myocardial_fiber1.41427010
50MP0003252_abnormal_bile_duct1.40611579
51MP0001188_hyperpigmentation1.40254471
52MP0000647_abnormal_sebaceous_gland1.40236884
53MP0006082_CNS_inflammation1.39399937
54MP0004133_heterotaxia1.39395550
55MP0003786_premature_aging1.38263237
56MP0000013_abnormal_adipose_tissue1.37126363
57MP0002148_abnormal_hypersensitivity_rea1.36765128
58MP0002572_abnormal_emotion/affect_behav1.35526725
59MP0002138_abnormal_hepatobiliary_system1.34283738
60MP0002332_abnormal_exercise_endurance1.33869305
61MP0005220_abnormal_exocrine_pancreas1.33653267
62MP0002160_abnormal_reproductive_system1.32759764
63MP0009785_altered_susceptibility_to1.32510578
64MP0002090_abnormal_vision1.31940469
65MP0002234_abnormal_pharynx_morphology1.31368100
66MP0001944_abnormal_pancreas_morphology1.29192152
67MP0008260_abnormal_autophagy1.27288747
68MP0003121_genomic_imprinting1.26546424
69MP0005174_abnormal_tail_pigmentation1.25099112
70MP0003635_abnormal_synaptic_transmissio1.24161095
71MP0005535_abnormal_body_temperature1.23756375
72MP0002638_abnormal_pupillary_reflex1.22788864
73MP0005499_abnormal_olfactory_system1.22667310
74MP0005394_taste/olfaction_phenotype1.22667310
75MP0005584_abnormal_enzyme/coenzyme_acti1.21978878
76MP0002067_abnormal_sensory_capabilities1.20629106
77MP0002063_abnormal_learning/memory/cond1.18886857
78MP0002254_reproductive_system_inflammat1.18575797
79MP0005084_abnormal_gallbladder_morpholo1.17622634
80MP0002693_abnormal_pancreas_physiology1.16708621
81MP0009764_decreased_sensitivity_to1.16288645
82MP0005248_abnormal_Harderian_gland1.16139146
83MP0000631_abnormal_neuroendocrine_gland1.15438440
84MP0000427_abnormal_hair_cycle1.15432678
85MP0005266_abnormal_metabolism1.15419714
86MP0002734_abnormal_mechanical_nocicepti1.14423606
87MP0005671_abnormal_response_to1.13838772
88MP0005171_absent_coat_pigmentation1.13695747
89MP0002928_abnormal_bile_duct1.13298481
90MP0001986_abnormal_taste_sensitivity1.12994279
91MP0000538_abnormal_urinary_bladder1.12667016
92MP0001486_abnormal_startle_reflex1.12277066
93MP0010386_abnormal_urinary_bladder1.11563763
94MP0001756_abnormal_urination1.10846510
95MP0001440_abnormal_grooming_behavior1.10388026
96MP0003436_decreased_susceptibility_to1.10232233
97MP0004924_abnormal_behavior1.08769579
98MP0005386_behavior/neurological_phenoty1.08769579
99MP0005451_abnormal_body_composition1.08167042
100MP0009379_abnormal_foot_pigmentation1.07885097
101MP0005376_homeostasis/metabolism_phenot1.07791403
102MP0006054_spinal_hemorrhage1.07693899
103MP0001501_abnormal_sleep_pattern1.05770436
104MP0002277_abnormal_respiratory_mucosa1.04393735
105MP0003656_abnormal_erythrocyte_physiolo1.03880280
106MP0008775_abnormal_heart_ventricle1.03726272
107MP0002233_abnormal_nose_morphology1.03142142
108MP0005075_abnormal_melanosome_morpholog1.02423107
109MP0002102_abnormal_ear_morphology1.00249146
110MP0003136_yellow_coat_color0.99527290
111MP0004134_abnormal_chest_morphology0.99316198
112MP0002751_abnormal_autonomic_nervous0.98883593
113MP0005391_vision/eye_phenotype0.98104603
114MP0005389_reproductive_system_phenotype0.97649234
115MP0003191_abnormal_cellular_cholesterol0.96935061
116MP0004019_abnormal_vitamin_homeostasis0.96742464
117MP0001293_anophthalmia0.96578502
118MP0003315_abnormal_perineum_morphology0.96044053
119MP0002118_abnormal_lipid_homeostasis0.95108488
120MP0004885_abnormal_endolymph0.95040781
121MP0003011_delayed_dark_adaptation0.95022718
122MP0002909_abnormal_adrenal_gland0.94297606
123MP0002419_abnormal_innate_immunity0.93285365
124MP0004270_analgesia0.93239158
125MP0006292_abnormal_olfactory_placode0.93044924
126MP0005000_abnormal_immune_tolerance0.91879353
127MP0008469_abnormal_protein_level0.90732466
128MP0001661_extended_life_span0.89917934
129MP0005319_abnormal_enzyme/_coenzyme0.89447165
130MP0002653_abnormal_ependyma_morphology0.88125099
131MP0000372_irregular_coat_pigmentation0.87074680
132MP0000639_abnormal_adrenal_gland0.85655568
133MP0005551_abnormal_eye_electrophysiolog0.84404271
134MP0005645_abnormal_hypothalamus_physiol0.83285053
135MP0004859_abnormal_synaptic_plasticity0.83039921
136MP0005025_abnormal_response_to0.82736288
137MP0001929_abnormal_gametogenesis0.82064500
138MP0002822_catalepsy0.81544130
139MP0002095_abnormal_skin_pigmentation0.81262228
140MP0005379_endocrine/exocrine_gland_phen0.80111512
141MP0002733_abnormal_thermal_nociception0.76713363
142MP0005646_abnormal_pituitary_gland0.76708267
143MP0005636_abnormal_mineral_homeostasis0.76094219
144MP0000015_abnormal_ear_pigmentation0.75933982
145MP0001970_abnormal_pain_threshold0.74951053
146MP0010094_abnormal_chromosome_stability0.74145987
147MP0008995_early_reproductive_senescence0.73242815
148MP0003868_abnormal_feces_composition0.72804689
149MP0009840_abnormal_foam_cell0.72636413
150MP0002163_abnormal_gland_morphology0.72516792
151MP0002132_abnormal_respiratory_system0.71830779
152MP0000653_abnormal_sex_gland0.71466400
153MP0002295_abnormal_pulmonary_circulatio0.70581383
154MP0002078_abnormal_glucose_homeostasis0.70415094
155MP0001666_abnormal_nutrient_absorption0.68975528
156MP0003718_maternal_effect0.68812904
157MP0002184_abnormal_innervation0.68187516
158MP0008872_abnormal_physiological_respon0.67796780
159MP0000566_synostosis0.67690351

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.84202640
2Abnormal mitochondria in muscle tissue (HP:0008316)5.39797756
3Acute encephalopathy (HP:0006846)5.08325523
4Progressive macrocephaly (HP:0004481)5.08319857
5Mitochondrial inheritance (HP:0001427)4.85608926
6Hepatocellular necrosis (HP:0001404)4.49885795
7Increased CSF lactate (HP:0002490)4.44207040
8Cerebral edema (HP:0002181)4.39143829
9Hepatic necrosis (HP:0002605)4.24572341
10Increased serum pyruvate (HP:0003542)4.14119277
11Abnormality of glycolysis (HP:0004366)4.14119277
12Hyperventilation (HP:0002883)3.65593706
133-Methylglutaconic aciduria (HP:0003535)3.56154384
14Prolonged partial thromboplastin time (HP:0003645)3.48684065
15True hermaphroditism (HP:0010459)3.38834419
16Optic disc pallor (HP:0000543)3.31565269
17Lactic acidosis (HP:0003128)3.28755130
18Hypobetalipoproteinemia (HP:0003563)3.25293952
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19063608
20Pancreatic cysts (HP:0001737)3.15201226
21Increased serum lactate (HP:0002151)3.14782256
22Pancreatic fibrosis (HP:0100732)3.12520795
23Intestinal atresia (HP:0011100)3.07303058
24Respiratory failure (HP:0002878)3.06728471
25Renal Fanconi syndrome (HP:0001994)3.03534671
26Joint hemorrhage (HP:0005261)3.03466631
27Exercise intolerance (HP:0003546)3.02837118
28Increased hepatocellular lipid droplets (HP:0006565)3.01442724
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.96149123
30Lipid accumulation in hepatocytes (HP:0006561)2.95582235
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90480048
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90480048
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89489336
34Conjugated hyperbilirubinemia (HP:0002908)2.89373514
35Focal motor seizures (HP:0011153)2.88325953
36Lethargy (HP:0001254)2.81347428
37Leukodystrophy (HP:0002415)2.77747234
38Recurrent gram-negative bacterial infections (HP:0005420)2.65625934
39Neuroendocrine neoplasm (HP:0100634)2.63004472
40Intrahepatic cholestasis (HP:0001406)2.62646638
41Progressive external ophthalmoplegia (HP:0000590)2.56508634
42Nephronophthisis (HP:0000090)2.56026035
43Ketoacidosis (HP:0001993)2.55982411
44Colon cancer (HP:0003003)2.51086424
45Increased intramyocellular lipid droplets (HP:0012240)2.49956712
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49143232
47Molar tooth sign on MRI (HP:0002419)2.45310304
48Abnormality of midbrain morphology (HP:0002418)2.45310304
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.43474309
50Febrile seizures (HP:0002373)2.39897331
51Abnormality of pyrimidine metabolism (HP:0004353)2.37987092
52Type I transferrin isoform profile (HP:0003642)2.36792810
53Abnormality of alanine metabolism (HP:0010916)2.35084896
54Hyperalaninemia (HP:0003348)2.35084896
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35084896
56Pheochromocytoma (HP:0002666)2.33792062
57Hyperglycinemia (HP:0002154)2.33080700
58Abnormality of methionine metabolism (HP:0010901)2.32207374
59Microvesicular hepatic steatosis (HP:0001414)2.31617424
60Abnormal protein glycosylation (HP:0012346)2.31488431
61Abnormal glycosylation (HP:0012345)2.31488431
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31488431
63Abnormal protein N-linked glycosylation (HP:0012347)2.31488431
64Sclerocornea (HP:0000647)2.29198289
65Methylmalonic aciduria (HP:0012120)2.28345112
66Tubulointerstitial nephritis (HP:0001970)2.24155585
67Hyperammonemia (HP:0001987)2.22449389
68Systemic lupus erythematosus (HP:0002725)2.22405724
69Increased muscle lipid content (HP:0009058)2.21826999
70X-linked dominant inheritance (HP:0001423)2.21062427
71Male pseudohermaphroditism (HP:0000037)2.20408954
72Chronic hepatic failure (HP:0100626)2.17682393
73Abnormality of vitamin B metabolism (HP:0004340)2.17501574
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.17340307
75Increased IgM level (HP:0003496)2.15797590
76Exertional dyspnea (HP:0002875)2.15294699
77Vomiting (HP:0002013)2.14219195
78Septo-optic dysplasia (HP:0100842)2.12618257
79Furrowed tongue (HP:0000221)2.10989060
80CNS demyelination (HP:0007305)2.10647510
81Poor head control (HP:0002421)2.10609030
82Fair hair (HP:0002286)2.09660656
83Abnormality of serum amino acid levels (HP:0003112)2.08428872
84Epileptic encephalopathy (HP:0200134)2.08002141
85Abnormality of the renal medulla (HP:0100957)2.07696598
86Metabolic acidosis (HP:0001942)2.06329326
87Glycosuria (HP:0003076)2.06190266
88Abnormality of urine glucose concentration (HP:0011016)2.06190266
89Ketosis (HP:0001946)2.05557290
90Hyperglycinuria (HP:0003108)2.04619108
91Medial flaring of the eyebrow (HP:0010747)2.04070414
92Hyperinsulinemic hypoglycemia (HP:0000825)2.03968121
93Epidermoid cyst (HP:0200040)2.03453172
94Xanthomatosis (HP:0000991)2.03058961
95Abnormality of renal resorption (HP:0011038)2.02434259
96Genital tract atresia (HP:0001827)2.02073972
97Hyperlipoproteinemia (HP:0010980)2.00239634
98Vaginal atresia (HP:0000148)2.00220277
99Atonic seizures (HP:0010819)1.99925775
100Nausea (HP:0002018)1.98578435
101Renal cortical cysts (HP:0000803)1.98117823
102Abnormal pupillary function (HP:0007686)1.97350749
103Abnormal hair whorl (HP:0010721)1.95740578
104Hyperbilirubinemia (HP:0002904)1.95716865
105Hypolipoproteinemia (HP:0010981)1.95555543
106Optic neuritis (HP:0100653)1.95548515
107Retrobulbar optic neuritis (HP:0100654)1.95548515
108Adrenal hypoplasia (HP:0000835)1.95453161
109Abnormality of serine family amino acid metabolism (HP:0010894)1.94868788
110Abnormality of glycine metabolism (HP:0010895)1.94868788
111Hemiparesis (HP:0001269)1.94157497
112Type II lissencephaly (HP:0007260)1.93248038
113Optic nerve hypoplasia (HP:0000609)1.93124268
114Abnormality of endocrine pancreas physiology (HP:0012093)1.93115706
115Abnormality of the pancreatic islet cells (HP:0006476)1.93115706
116Abnormal biliary tract physiology (HP:0012439)1.92856536
117Bile duct proliferation (HP:0001408)1.92856536
118Methylmalonic acidemia (HP:0002912)1.91661296
119Acute hepatic failure (HP:0006554)1.91545426
120Complement deficiency (HP:0004431)1.91410712
121Supernumerary spleens (HP:0009799)1.91280970
122Double outlet right ventricle (HP:0001719)1.90548446
123Congenital malformation of the right heart (HP:0011723)1.90548446
124Cystic liver disease (HP:0006706)1.88674159
125Abnormality of the renal cortex (HP:0011035)1.87995128
126Parakeratosis (HP:0001036)1.85868921
127Hyperglycemia (HP:0003074)1.85864909
128Hypothermia (HP:0002045)1.85466332
129Hypoglycemic seizures (HP:0002173)1.83719291
130Fat malabsorption (HP:0002630)1.82213842
131Myokymia (HP:0002411)1.81505043
132Deep venous thrombosis (HP:0002625)1.80543247
133Aplasia/hypoplasia of the uterus (HP:0008684)1.80167606
134Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79731966
135Occipital encephalocele (HP:0002085)1.78633168
136Hypophosphatemic rickets (HP:0004912)1.78593802
137Respiratory difficulties (HP:0002880)1.78229922
138Gliosis (HP:0002171)1.78194971
139Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77134837
140Abnormality of fatty-acid metabolism (HP:0004359)1.76737457
141Decreased testicular size (HP:0008734)1.74785655
142Median cleft lip (HP:0000161)1.74516814
143Postaxial hand polydactyly (HP:0001162)1.73961913
144Hypoglycemic coma (HP:0001325)1.71978895
145Gait imbalance (HP:0002141)1.71918028
146Nephrogenic diabetes insipidus (HP:0009806)1.71593642
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70894344
148Dicarboxylic aciduria (HP:0003215)1.70894344
149Stomatitis (HP:0010280)1.70726793
150Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70479261
151Hypoalbuminemia (HP:0003073)1.70440134
152Abnormal albumin level (HP:0012116)1.70440134
153Blue irides (HP:0000635)1.70274719
154Disproportionate short-trunk short stature (HP:0003521)1.69794819
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68522266
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.68277686
157Congenital primary aphakia (HP:0007707)1.68199459
158Generalized aminoaciduria (HP:0002909)1.67910829
159Absence seizures (HP:0002121)1.64090923
160Eczematoid dermatitis (HP:0000976)1.63512367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.38138885
2MAP4K24.14076508
3TRIM282.85970805
4MAP3K122.79658196
5MST42.75771021
6MAP2K72.71488888
7WNK32.69936450
8STK162.50677828
9MAP3K142.33115999
10PBK2.26450434
11PLK22.14458286
12EIF2AK12.01297197
13ARAF1.97894444
14TXK1.97262732
15ZAK1.93546820
16RIPK41.92720257
17IRAK31.81113552
18NUAK11.71722063
19BMPR21.70011122
20MAP3K41.63646091
21GRK71.63050272
22NME11.61124428
23NME21.57458504
24BRAF1.56468075
25BCR1.56350680
26NTRK31.55248422
27FGFR21.54980077
28SIK31.54970707
29CSNK1G11.53840648
30PDK21.49300063
31AKT31.46619607
32MYLK1.46592620
33YES11.42702124
34TAOK21.35741763
35IRAK41.34110405
36NEK11.30919326
37STK391.23524064
38PHKG21.23365550
39PHKG11.23365550
40PRPF4B1.23247369
41MAP2K41.21916474
42KDR1.21535199
43MKNK21.20453104
44CSNK1G21.19101714
45SRPK11.16984625
46INSRR1.16891463
47BLK1.16844993
48CSNK1A1L1.16744386
49EIF2AK31.15928478
50ADRBK21.15683532
51ABL21.14282042
52PDK31.14099229
53PDK41.14099229
54ERBB41.12903219
55WNK41.10074579
56PIM21.09701479
57MKNK11.09454346
58TAOK31.06914348
59NEK91.06450517
60MARK11.06330146
61BCKDK1.05593566
62MINK11.03651274
63STK38L1.01236839
64EPHA41.00866358
65MAP3K130.99536455
66LIMK10.97644736
67MAPK130.97606424
68PAK30.97022653
69TLK10.96950472
70BUB10.95946112
71OBSCN0.95082567
72SCYL20.94666423
73BMPR1B0.93766309
74PLK40.92469052
75PRKCG0.90609326
76CAMK2A0.89760156
77ERBB30.89102108
78ACVR1B0.88133101
79EIF2AK20.86400377
80PINK10.84089807
81FER0.83854466
82DYRK30.83488024
83FLT30.82306524
84RPS6KA40.79048981
85GRK50.77677965
86PNCK0.76834179
87PRKCE0.76492091
88PRKCQ0.75500007
89FRK0.75386161
90VRK20.75368096
91CAMK2B0.75216266
92DYRK20.74603722
93BRSK20.74082620
94SGK20.73704463
95CCNB10.72713288
96PLK10.71977721
97CAMK2G0.70842882
98NEK60.67492923
99SYK0.67114643
100IRAK20.64851301
101PIK3CG0.64382535
102ILK0.63111197
103PIK3CA0.60926038
104OXSR10.58744973
105STK30.58705040
106RPS6KA50.57006659
107FES0.56602179
108TESK10.56062800
109PKN10.55655463
110TNIK0.55520659
111DAPK10.54601992
112SGK4940.53164497
113SGK2230.53164497
114MAP3K110.52692834
115CSNK1A10.52592940
116LYN0.51856157
117MARK30.50946118
118GRK60.50148597
119GRK10.50136980
120PRKACA0.49104950
121CSNK1G30.48805408
122IKBKB0.47500081
123PRKCD0.46723053
124CAMKK20.46576644
125PLK30.45852744
126ATM0.45330551
127CAMK2D0.43706510
128ADRBK10.43216477
129ROCK10.43197100
130STK240.43127231
131AURKB0.42982256
132TEC0.42655989
133PTK2B0.41904222
134VRK10.40985727
135TSSK60.40532000
136IRAK10.40231027
137TTK0.38397725
138CDC70.38105854
139AKT20.37556887
140FGR0.37139992
141PRKCI0.37013334
142TIE10.36997762
143TESK20.36102300
144CSNK2A10.35356567
145CDK190.35147225
146MAP3K50.34457065
147PRKD30.34451824
148STK40.33972638
149MUSK0.33251059
150TGFBR10.31954479
151CDK30.30768978
152CSNK2A20.30725734
153NLK0.29290611

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.73462206
2Parkinsons disease_Homo sapiens_hsa050123.81719196
3Alzheimers disease_Homo sapiens_hsa050102.94534374
4Proteasome_Homo sapiens_hsa030502.70306025
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.66214173
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62471910
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61486312
8Huntingtons disease_Homo sapiens_hsa050162.58661430
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46139082
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.39263381
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11131396
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96291693
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90431375
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87347357
15Peroxisome_Homo sapiens_hsa041461.87312613
16Fatty acid elongation_Homo sapiens_hsa000621.86706541
17Homologous recombination_Homo sapiens_hsa034401.83738374
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83735588
19Collecting duct acid secretion_Homo sapiens_hsa049661.78895520
20Pyruvate metabolism_Homo sapiens_hsa006201.77021888
21Propanoate metabolism_Homo sapiens_hsa006401.74901609
22Cardiac muscle contraction_Homo sapiens_hsa042601.69862193
23Complement and coagulation cascades_Homo sapiens_hsa046101.64378202
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64251120
25Nicotine addiction_Homo sapiens_hsa050331.62668251
26Tryptophan metabolism_Homo sapiens_hsa003801.56742922
27Basal transcription factors_Homo sapiens_hsa030221.56207026
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50176716
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48732889
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47550481
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44188876
32Arginine biosynthesis_Homo sapiens_hsa002201.42429841
33Staphylococcus aureus infection_Homo sapiens_hsa051501.42225631
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40258296
35Butanoate metabolism_Homo sapiens_hsa006501.39748154
36Sulfur metabolism_Homo sapiens_hsa009201.37810789
37Protein export_Homo sapiens_hsa030601.33075152
38RNA degradation_Homo sapiens_hsa030181.32438380
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32400050
40One carbon pool by folate_Homo sapiens_hsa006701.29535670
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.28069980
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27857304
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27761203
44Steroid biosynthesis_Homo sapiens_hsa001001.26181980
45Selenocompound metabolism_Homo sapiens_hsa004501.23377752
46Mismatch repair_Homo sapiens_hsa034301.22246942
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21755322
48beta-Alanine metabolism_Homo sapiens_hsa004101.21291310
49Non-homologous end-joining_Homo sapiens_hsa034501.17852493
50Graft-versus-host disease_Homo sapiens_hsa053321.17156048
51Phenylalanine metabolism_Homo sapiens_hsa003601.16596042
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14790718
53Carbon metabolism_Homo sapiens_hsa012001.14121288
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13550673
55Fanconi anemia pathway_Homo sapiens_hsa034601.13528871
56Tyrosine metabolism_Homo sapiens_hsa003501.12711927
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10578692
58Fatty acid degradation_Homo sapiens_hsa000711.09574375
59Histidine metabolism_Homo sapiens_hsa003401.09494959
60Chemical carcinogenesis_Homo sapiens_hsa052041.07853118
61Nitrogen metabolism_Homo sapiens_hsa009101.02010709
62Retinol metabolism_Homo sapiens_hsa008301.00704214
63Rheumatoid arthritis_Homo sapiens_hsa053231.00184474
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99384624
65Vitamin B6 metabolism_Homo sapiens_hsa007500.97173573
66Synaptic vesicle cycle_Homo sapiens_hsa047210.95780168
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94810887
68Phagosome_Homo sapiens_hsa041450.93166364
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.92851056
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.91064001
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90774234
72Metabolic pathways_Homo sapiens_hsa011000.88877687
73Sulfur relay system_Homo sapiens_hsa041220.88576736
74Allograft rejection_Homo sapiens_hsa053300.88565218
75Nucleotide excision repair_Homo sapiens_hsa034200.86301654
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86176978
77Starch and sucrose metabolism_Homo sapiens_hsa005000.86158203
78Ribosome_Homo sapiens_hsa030100.86115113
79Insulin secretion_Homo sapiens_hsa049110.84552085
80Fatty acid metabolism_Homo sapiens_hsa012120.83594536
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78674484
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77617221
83RNA transport_Homo sapiens_hsa030130.77591522
84Vibrio cholerae infection_Homo sapiens_hsa051100.75356668
85Arginine and proline metabolism_Homo sapiens_hsa003300.74786224
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74760141
87Base excision repair_Homo sapiens_hsa034100.71293203
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71241037
89PPAR signaling pathway_Homo sapiens_hsa033200.68451745
90Spliceosome_Homo sapiens_hsa030400.68153187
91Type I diabetes mellitus_Homo sapiens_hsa049400.67837419
92Ether lipid metabolism_Homo sapiens_hsa005650.67008050
93Asthma_Homo sapiens_hsa053100.64986770
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64197966
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60996728
96Biosynthesis of amino acids_Homo sapiens_hsa012300.59959791
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59828955
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58778049
99Vitamin digestion and absorption_Homo sapiens_hsa049770.58109179
100Autoimmune thyroid disease_Homo sapiens_hsa053200.55761193
101Olfactory transduction_Homo sapiens_hsa047400.54562300
102N-Glycan biosynthesis_Homo sapiens_hsa005100.51453599
103Circadian rhythm_Homo sapiens_hsa047100.51291800
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49899346
105Mineral absorption_Homo sapiens_hsa049780.48272167
106African trypanosomiasis_Homo sapiens_hsa051430.47654964
107Regulation of autophagy_Homo sapiens_hsa041400.47634828
108Folate biosynthesis_Homo sapiens_hsa007900.46166272
109DNA replication_Homo sapiens_hsa030300.45792282
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.45384550
111Serotonergic synapse_Homo sapiens_hsa047260.44957023
112Oocyte meiosis_Homo sapiens_hsa041140.44377993
113GABAergic synapse_Homo sapiens_hsa047270.42478146
114Glutathione metabolism_Homo sapiens_hsa004800.42452426
115Pyrimidine metabolism_Homo sapiens_hsa002400.39417020
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36309999
117Taste transduction_Homo sapiens_hsa047420.34879086
118Hedgehog signaling pathway_Homo sapiens_hsa043400.33394130
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32977395
120RNA polymerase_Homo sapiens_hsa030200.31387606
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31233031
122Legionellosis_Homo sapiens_hsa051340.30305812
123Morphine addiction_Homo sapiens_hsa050320.30158799
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29827756
125p53 signaling pathway_Homo sapiens_hsa041150.29327477
126Prion diseases_Homo sapiens_hsa050200.28676403
127Fat digestion and absorption_Homo sapiens_hsa049750.28222343
128Phototransduction_Homo sapiens_hsa047440.28034051
129Primary immunodeficiency_Homo sapiens_hsa053400.26336681
130Purine metabolism_Homo sapiens_hsa002300.26008459
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25935522
132Linoleic acid metabolism_Homo sapiens_hsa005910.24802577
133Caffeine metabolism_Homo sapiens_hsa002320.21630832
134Pertussis_Homo sapiens_hsa051330.20279066
135Bile secretion_Homo sapiens_hsa049760.20143365
136Arachidonic acid metabolism_Homo sapiens_hsa005900.17575365
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16678844

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