TTBK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05603351
2synaptic vesicle maturation (GO:0016188)6.05045388
3locomotory exploration behavior (GO:0035641)5.81058131
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.65950981
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54514562
6vocalization behavior (GO:0071625)5.43242998
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15954084
8glutamate secretion (GO:0014047)4.97879923
9synaptic vesicle exocytosis (GO:0016079)4.90566710
10cerebellar granule cell differentiation (GO:0021707)4.86487025
11regulation of synaptic vesicle exocytosis (GO:2000300)4.85577903
12regulation of glutamate receptor signaling pathway (GO:1900449)4.75549665
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.75122319
14protein localization to synapse (GO:0035418)4.69552402
15layer formation in cerebral cortex (GO:0021819)4.57751088
16exploration behavior (GO:0035640)4.48648234
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.46311219
18dendritic spine morphogenesis (GO:0060997)4.43979353
19regulation of neuronal synaptic plasticity (GO:0048168)4.39683396
20neuron cell-cell adhesion (GO:0007158)4.35961217
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32827756
22neurotransmitter secretion (GO:0007269)4.30635351
23regulation of synaptic vesicle transport (GO:1902803)4.30244142
24gamma-aminobutyric acid transport (GO:0015812)4.24892929
25neuronal action potential propagation (GO:0019227)4.23724495
26regulation of synapse structural plasticity (GO:0051823)4.23551221
27synaptic transmission, glutamatergic (GO:0035249)4.00563126
28neurotransmitter-gated ion channel clustering (GO:0072578)3.97707190
29amino acid import (GO:0043090)3.92775030
30axon ensheathment in central nervous system (GO:0032291)3.90325892
31central nervous system myelination (GO:0022010)3.90325892
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88335420
33glutamate receptor signaling pathway (GO:0007215)3.83283889
34regulation of synapse maturation (GO:0090128)3.80687111
35calcium ion-dependent exocytosis (GO:0017156)3.77107815
36potassium ion homeostasis (GO:0055075)3.76890945
37presynaptic membrane organization (GO:0097090)3.76060396
38presynaptic membrane assembly (GO:0097105)3.74067497
39long-term memory (GO:0007616)3.73846739
40proline transport (GO:0015824)3.73046544
41positive regulation of membrane potential (GO:0045838)3.71747840
42neuron-neuron synaptic transmission (GO:0007270)3.69692511
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65654773
44cellular potassium ion homeostasis (GO:0030007)3.65433534
45glycine transport (GO:0015816)3.64475216
46neuromuscular synaptic transmission (GO:0007274)3.61231758
47neuromuscular process controlling balance (GO:0050885)3.57967576
48membrane depolarization during action potential (GO:0086010)3.57171318
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56508937
50establishment of mitochondrion localization (GO:0051654)3.56388881
51regulation of dendritic spine morphogenesis (GO:0061001)3.53350720
52auditory behavior (GO:0031223)3.53184761
53potassium ion import (GO:0010107)3.52672565
54sodium ion export (GO:0071436)3.50531877
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.50452114
56acrosome reaction (GO:0007340)3.50363474
57neurotransmitter transport (GO:0006836)3.50174354
58regulation of voltage-gated calcium channel activity (GO:1901385)3.45818390
59transmission of nerve impulse (GO:0019226)3.43904087
60dendrite morphogenesis (GO:0048813)3.40856181
61neuronal ion channel clustering (GO:0045161)3.39545337
62regulation of postsynaptic membrane potential (GO:0060078)3.39332954
63neuron recognition (GO:0008038)3.38608474
64cell differentiation in hindbrain (GO:0021533)3.37745605
65response to auditory stimulus (GO:0010996)3.37223023
66regulation of neurotransmitter secretion (GO:0046928)3.36768452
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36692522
68cerebellar Purkinje cell differentiation (GO:0021702)3.36447677
69prepulse inhibition (GO:0060134)3.34248731
70regulation of synaptic plasticity (GO:0048167)3.34243274
71activation of protein kinase A activity (GO:0034199)3.32273549
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31595539
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30111487
74positive regulation of synapse maturation (GO:0090129)3.25823037
75cellular sodium ion homeostasis (GO:0006883)3.24764093
76synaptic vesicle endocytosis (GO:0048488)3.23248535
77postsynaptic membrane organization (GO:0001941)3.22323958
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.20268201
79negative regulation of dendrite morphogenesis (GO:0050774)3.19815561
80regulation of neurotransmitter levels (GO:0001505)3.19232093
81mechanosensory behavior (GO:0007638)3.18786998
82L-amino acid import (GO:0043092)3.18334226
83sperm motility (GO:0030317)3.16509411
84membrane depolarization (GO:0051899)3.16065469
85axonal fasciculation (GO:0007413)3.15228169
86establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.13081824
87mitochondrion transport along microtubule (GO:0047497)3.13081824
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11705464
89regulation of neurotransmitter transport (GO:0051588)3.11165897
90dendritic spine organization (GO:0097061)3.09542930
91regulation of ARF protein signal transduction (GO:0032012)3.08079033
92positive regulation of dendritic spine development (GO:0060999)3.05812729
93cell migration in hindbrain (GO:0021535)3.05364009
94neuromuscular process controlling posture (GO:0050884)3.03881929
95positive regulation of neurotransmitter secretion (GO:0001956)3.03537792
96positive regulation of neurotransmitter transport (GO:0051590)3.02053213
97regulation of dendrite morphogenesis (GO:0048814)3.01333564
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01094848
99synaptic transmission (GO:0007268)3.00889908
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99222097
101regulation of dendritic spine development (GO:0060998)2.98875749
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98137951
103acidic amino acid transport (GO:0015800)2.97865367
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97862336
105vesicle transport along microtubule (GO:0047496)2.97385401
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97282691
107membrane hyperpolarization (GO:0060081)2.96526238
108regulation of vesicle fusion (GO:0031338)2.96366999
109synapse assembly (GO:0007416)2.93817635
110cell communication by electrical coupling (GO:0010644)2.93747166
111learning (GO:0007612)2.92849331
112cilium or flagellum-dependent cell motility (GO:0001539)2.90333187
113neuromuscular process (GO:0050905)2.89287558
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89151100
115intraspecies interaction between organisms (GO:0051703)2.88034329
116social behavior (GO:0035176)2.88034329
117G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87756832
118long-term synaptic potentiation (GO:0060291)2.87685548
119central nervous system projection neuron axonogenesis (GO:0021952)2.85215920
120gamma-aminobutyric acid signaling pathway (GO:0007214)2.84684155
121mating behavior (GO:0007617)2.84583930
122regulation of synaptic transmission (GO:0050804)2.82041281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12006621
2GBX2_23144817_ChIP-Seq_PC3_Human2.85254869
3REST_21632747_ChIP-Seq_MESCs_Mouse2.75899618
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74968463
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71901034
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59023492
7DROSHA_22980978_ChIP-Seq_HELA_Human2.55770901
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44919068
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44919068
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.43168712
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41852006
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35375059
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34686604
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.32707995
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29123647
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.27997492
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22387903
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17722270
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16696479
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15733526
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.15161144
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.12029544
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09407889
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08333238
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04997274
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99433544
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97611045
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.92666154
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92122568
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77925948
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56909337
32AR_21572438_ChIP-Seq_LNCaP_Human1.51489582
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49884432
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47181627
35SMAD4_21799915_ChIP-Seq_A2780_Human1.45900531
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45647878
37ZNF274_21170338_ChIP-Seq_K562_Hela1.44840379
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35906655
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35105506
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.33731246
41TAF15_26573619_Chip-Seq_HEK293_Human1.33586866
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.32610919
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.32365090
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31577349
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30986109
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30499732
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27695316
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24324831
49* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23100563
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20873308
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19846159
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18440108
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16766573
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16701629
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.15845364
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15480638
57STAT3_23295773_ChIP-Seq_U87_Human1.13870198
58RNF2_27304074_Chip-Seq_NSC_Mouse1.13728680
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.13489907
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12924948
61KDM2B_26808549_Chip-Seq_K562_Human1.12906242
62* AR_19668381_ChIP-Seq_PC3_Human1.10251205
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.08364182
64AR_25329375_ChIP-Seq_VCAP_Human1.07650423
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.07110037
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06954566
67TCF4_23295773_ChIP-Seq_U87_Human1.06208164
68P300_19829295_ChIP-Seq_ESCs_Human1.05392458
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03558564
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02971729
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02700613
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.02608114
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02410433
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01582292
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01035087
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99634153
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99393202
78ARNT_22903824_ChIP-Seq_MCF-7_Human0.99283585
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98479468
80P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98292037
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98031526
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96919250
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96919250
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.96175424
85BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95091335
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94924093
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94790441
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94184186
89AHR_22903824_ChIP-Seq_MCF-7_Human0.93660429
90CTCF_27219007_Chip-Seq_Bcells_Human0.93242173
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92230527
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91959717
93OCT4_19829295_ChIP-Seq_ESCs_Human0.91847460
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91777655
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.91040024
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90284338
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.90015816
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89700066
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89318410
100* LXR_22292898_ChIP-Seq_THP-1_Human0.89011119
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88704716
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.88693204
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87777272
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87321751
105ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87154555
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86859577
107* DPY_21335234_ChIP-Seq_ESCs_Mouse0.86837912
108RUNX2_22187159_ChIP-Seq_PCA_Human0.85780597
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.85132860
110* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84527745
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84217834
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83709313
113KDM2B_26808549_Chip-Seq_REH_Human0.83241166
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.82774472
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81696983
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.81444260
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.81426710
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80703969
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80315058
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80110734
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79949888
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78851740
123KLF4_19829295_ChIP-Seq_ESCs_Human0.78064882
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77972140
125SMC4_20622854_ChIP-Seq_HELA_Human0.77928448
126SOX9_26525672_Chip-Seq_HEART_Mouse0.76329567
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74419423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.64256784
2MP0003880_abnormal_central_pattern4.20427815
3MP0003635_abnormal_synaptic_transmissio4.08357235
4MP0004270_analgesia3.91196182
5MP0009046_muscle_twitch3.30740573
6MP0009745_abnormal_behavioral_response3.28990735
7MP0002063_abnormal_learning/memory/cond3.26006198
8MP0005423_abnormal_somatic_nervous3.24728002
9MP0005410_abnormal_fertilization3.06640531
10MP0002064_seizures3.02277284
11MP0002822_catalepsy2.94325810
12MP0001968_abnormal_touch/_nociception2.92802978
13MP0002734_abnormal_mechanical_nocicepti2.71193954
14MP0002572_abnormal_emotion/affect_behav2.67500537
15MP0001486_abnormal_startle_reflex2.65583173
16MP0002272_abnormal_nervous_system2.53543527
17MP0002735_abnormal_chemical_nociception2.20486145
18MP0002736_abnormal_nociception_after2.14858346
19MP0002733_abnormal_thermal_nociception2.03430358
20MP0001440_abnormal_grooming_behavior2.02727302
21MP0008569_lethality_at_weaning2.02627048
22MP0001501_abnormal_sleep_pattern2.01235386
23MP0001970_abnormal_pain_threshold1.93722996
24MP0004811_abnormal_neuron_physiology1.92552225
25MP0000778_abnormal_nervous_system1.90383803
26MP0002067_abnormal_sensory_capabilities1.89645337
27MP0004858_abnormal_nervous_system1.84808624
28MP0002184_abnormal_innervation1.84289947
29MP0003123_paternal_imprinting1.80667626
30MP0002557_abnormal_social/conspecific_i1.80310805
31MP0001984_abnormal_olfaction1.78589655
32MP0003329_amyloid_beta_deposits1.78366095
33MP0009780_abnormal_chondrocyte_physiolo1.75866553
34MP0000955_abnormal_spinal_cord1.68533535
35MP0002909_abnormal_adrenal_gland1.65891957
36MP0003879_abnormal_hair_cell1.63926782
37MP0004885_abnormal_endolymph1.63165590
38MP0004924_abnormal_behavior1.61083637
39MP0005386_behavior/neurological_phenoty1.61083637
40MP0005646_abnormal_pituitary_gland1.53050515
41MP0002882_abnormal_neuron_morphology1.47466683
42MP0005645_abnormal_hypothalamus_physiol1.43808323
43MP0003787_abnormal_imprinting1.42740591
44MP0002066_abnormal_motor_capabilities/c1.42591133
45MP0003633_abnormal_nervous_system1.39652256
46MP0006276_abnormal_autonomic_nervous1.37401681
47MP0003698_abnormal_male_reproductive1.33730596
48MP0002638_abnormal_pupillary_reflex1.31100036
49MP0000569_abnormal_digit_pigmentation1.27050560
50MP0004142_abnormal_muscle_tone1.25400670
51MP0002152_abnormal_brain_morphology1.19790159
52MP0003631_nervous_system_phenotype1.17944474
53MP0001502_abnormal_circadian_rhythm1.15166703
54MP0001529_abnormal_vocalization1.06273578
55MP0004742_abnormal_vestibular_system1.05106650
56MP0002229_neurodegeneration1.01174066
57MP0000920_abnormal_myelination0.99891755
58MP0001905_abnormal_dopamine_level0.99691249
59MP0003121_genomic_imprinting0.98750261
60MP0003283_abnormal_digestive_organ0.97073264
61MP0001177_atelectasis0.94527649
62MP0003634_abnormal_glial_cell0.94223276
63MP0001348_abnormal_lacrimal_gland0.93332509
64MP0008872_abnormal_physiological_respon0.93165187
65MP0003690_abnormal_glial_cell0.92931291
66MP0002069_abnormal_eating/drinking_beha0.89796762
67MP0008961_abnormal_basal_metabolism0.89138624
68MP0005623_abnormal_meninges_morphology0.85970783
69MP0005551_abnormal_eye_electrophysiolog0.85842782
70MP0004145_abnormal_muscle_electrophysio0.84842121
71MP0003632_abnormal_nervous_system0.84428769
72MP0008877_abnormal_DNA_methylation0.84240895
73MP0008874_decreased_physiological_sensi0.83849578
74MP0002653_abnormal_ependyma_morphology0.83434362
75MP0001963_abnormal_hearing_physiology0.83101250
76MP0005499_abnormal_olfactory_system0.82962532
77MP0005394_taste/olfaction_phenotype0.82962532
78MP0000751_myopathy0.81394192
79MP0002752_abnormal_somatic_nervous0.81129246
80MP0000631_abnormal_neuroendocrine_gland0.80932953
81MP0003075_altered_response_to0.79297281
82MP0001188_hyperpigmentation0.78838051
83MP0004130_abnormal_muscle_cell0.76652218
84MP0001929_abnormal_gametogenesis0.76317379
85MP0004085_abnormal_heartbeat0.74418787
86MP0000566_synostosis0.73761952
87MP0000604_amyloidosis0.72314883
88MP0000026_abnormal_inner_ear0.72304824
89MP0002161_abnormal_fertility/fecundity0.72266926
90MP0005409_darkened_coat_color0.72253336
91MP0001485_abnormal_pinna_reflex0.71351191
92MP0003861_abnormal_nervous_system0.70849213
93MP0005535_abnormal_body_temperature0.70757645
94MP0004233_abnormal_muscle_weight0.68714640
95MP0004147_increased_porphyrin_level0.67821984
96MP0002102_abnormal_ear_morphology0.63639489
97MP0000013_abnormal_adipose_tissue0.63482139
98MP0010386_abnormal_urinary_bladder0.62177752
99MP0002082_postnatal_lethality0.60335683
100MP0003122_maternal_imprinting0.60048711
101MP0003137_abnormal_impulse_conducting0.59906616
102MP0001346_abnormal_lacrimal_gland0.59532059
103MP0003938_abnormal_ear_development0.58936370
104MP0010768_mortality/aging0.58471457
105MP0002090_abnormal_vision0.56599945
106MP0004043_abnormal_pH_regulation0.55890444
107MP0010769_abnormal_survival0.55568779
108MP0005167_abnormal_blood-brain_barrier0.54794580
109MP0002249_abnormal_larynx_morphology0.54748786
110MP0001299_abnormal_eye_distance/0.54362069
111MP0001943_abnormal_respiration0.53507310
112MP0003172_abnormal_lysosome_physiology0.53221153
113MP0004133_heterotaxia0.53089640
114MP0010770_preweaning_lethality0.52540679
115MP0002081_perinatal_lethality0.50887392
116MP0000579_abnormal_nail_morphology0.49967467
117MP0001986_abnormal_taste_sensitivity0.49578336

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.85543276
2Focal motor seizures (HP:0011153)6.11887517
3Focal seizures (HP:0007359)5.02844392
4Absent/shortened dynein arms (HP:0200106)4.66718477
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.66718477
6Visual hallucinations (HP:0002367)4.55293196
7Progressive cerebellar ataxia (HP:0002073)4.24316309
8Epileptic encephalopathy (HP:0200134)4.13014052
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.98255561
10Action tremor (HP:0002345)3.95096167
11Supranuclear gaze palsy (HP:0000605)3.88003041
12Ankle clonus (HP:0011448)3.80669594
13Febrile seizures (HP:0002373)3.71937389
14Atonic seizures (HP:0010819)3.60177897
15Impaired vibration sensation in the lower limbs (HP:0002166)3.36119063
16Mutism (HP:0002300)3.29996212
17Gaze-evoked nystagmus (HP:0000640)3.27865705
18Abnormal respiratory motile cilium physiology (HP:0012261)3.27518526
19Absence seizures (HP:0002121)3.23924794
20Urinary bladder sphincter dysfunction (HP:0002839)3.23316130
21Generalized tonic-clonic seizures (HP:0002069)3.21559981
22Abnormality of the lower motor neuron (HP:0002366)3.18593875
23Broad-based gait (HP:0002136)3.10871569
24Abnormal respiratory epithelium morphology (HP:0012253)3.07274983
25Abnormal respiratory motile cilium morphology (HP:0005938)3.07274983
26Poor eye contact (HP:0000817)3.06453680
27Dysdiadochokinesis (HP:0002075)2.96229168
28Papilledema (HP:0001085)2.95922730
29Depression (HP:0000716)2.95792186
30Dialeptic seizures (HP:0011146)2.94798814
31Postural instability (HP:0002172)2.94075421
32Hemiparesis (HP:0001269)2.92629123
33Neurofibrillary tangles (HP:0002185)2.89776518
34Sleep apnea (HP:0010535)2.88551866
35Dysmetria (HP:0001310)2.87263049
36Abnormal ciliary motility (HP:0012262)2.84673203
37Urinary urgency (HP:0000012)2.82242091
38Spastic gait (HP:0002064)2.78971092
39Akinesia (HP:0002304)2.75183907
40Abnormal eating behavior (HP:0100738)2.74005498
41Genetic anticipation (HP:0003743)2.71134749
42Tetraplegia (HP:0002445)2.68522188
43Abnormal social behavior (HP:0012433)2.68094458
44Impaired social interactions (HP:0000735)2.68094458
45Intention tremor (HP:0002080)2.63563772
46Torticollis (HP:0000473)2.60913161
47Truncal ataxia (HP:0002078)2.60537385
48Cerebral hypomyelination (HP:0006808)2.60413109
49Rhinitis (HP:0012384)2.59291087
50Abnormality of the corticospinal tract (HP:0002492)2.58685216
51Cerebral inclusion bodies (HP:0100314)2.57707770
52Impaired smooth pursuit (HP:0007772)2.55678555
53Anxiety (HP:0000739)2.55526697
54Amyotrophic lateral sclerosis (HP:0007354)2.51784528
55Insidious onset (HP:0003587)2.46327746
56Termporal pattern (HP:0011008)2.46327746
57Amblyopia (HP:0000646)2.45927849
58Limb dystonia (HP:0002451)2.44458592
59Insomnia (HP:0100785)2.41038673
60Megalencephaly (HP:0001355)2.40759769
61Abnormality of ocular smooth pursuit (HP:0000617)2.40548503
62Hyperventilation (HP:0002883)2.40191861
63Lower limb muscle weakness (HP:0007340)2.39662462
64Focal dystonia (HP:0004373)2.38118198
65Progressive inability to walk (HP:0002505)2.34464032
66Ventricular fibrillation (HP:0001663)2.34406917
67Impaired vibratory sensation (HP:0002495)2.33763808
68Hemiplegia (HP:0002301)2.33298725
69Drooling (HP:0002307)2.32206270
70Excessive salivation (HP:0003781)2.32206270
71Morphological abnormality of the pyramidal tract (HP:0002062)2.28802317
72Stereotypic behavior (HP:0000733)2.26064940
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24474853
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.24474853
75Infertility (HP:0000789)2.23446588
76Peripheral hypomyelination (HP:0007182)2.22791538
77Bradykinesia (HP:0002067)2.22207722
78Diplopia (HP:0000651)2.21510070
79Abnormality of binocular vision (HP:0011514)2.21510070
80Turricephaly (HP:0000262)2.19266891
81Absent speech (HP:0001344)2.15614572
82Aplasia involving bones of the upper limbs (HP:0009823)2.14208286
83Scanning speech (HP:0002168)2.13716248
84Clonus (HP:0002169)2.12253849
85Pointed chin (HP:0000307)2.08837859
86Bundle branch block (HP:0011710)2.08467210
87Obstructive sleep apnea (HP:0002870)2.07933090
88Fetal akinesia sequence (HP:0001989)2.06487375
89Craniofacial dystonia (HP:0012179)2.05751457
90Dysmetric saccades (HP:0000641)2.02513995
91Status epilepticus (HP:0002133)2.02054891
92Spastic tetraparesis (HP:0001285)2.00397206
93Annular pancreas (HP:0001734)2.00326766
94Abnormality of saccadic eye movements (HP:0000570)1.99565773
95Diminished motivation (HP:0000745)1.97752936
96Neuronal loss in central nervous system (HP:0002529)1.95946883
97Epileptiform EEG discharges (HP:0011182)1.93913236
98Delusions (HP:0000746)1.93536171
99EEG with generalized epileptiform discharges (HP:0011198)1.92788678
100Incomplete penetrance (HP:0003829)1.92645243
101Polyphagia (HP:0002591)1.92604444
102Inappropriate behavior (HP:0000719)1.89776230
103Inability to walk (HP:0002540)1.89469700
104Hypsarrhythmia (HP:0002521)1.86905186
105Lower limb amyotrophy (HP:0007210)1.86628236
106Rigidity (HP:0002063)1.84737646
107Agitation (HP:0000713)1.84541285
108Gait ataxia (HP:0002066)1.83031431
109Hypoplasia of the corpus callosum (HP:0002079)1.80776877
110Prolonged QT interval (HP:0001657)1.79691473
111CNS hypomyelination (HP:0003429)1.79036658
112Apathy (HP:0000741)1.78375999
113Generalized myoclonic seizures (HP:0002123)1.77695316
114Choreoathetosis (HP:0001266)1.75230957
115Anosmia (HP:0000458)1.72825875
116Chronic bronchitis (HP:0004469)1.72428686
117Bronchomalacia (HP:0002780)1.71669809
118Split foot (HP:0001839)1.71536071
119Aplasia of the phalanges of the hand (HP:0009802)1.70861283
120Aplasia involving bones of the extremities (HP:0009825)1.70861283
121Spastic tetraplegia (HP:0002510)1.70337154
122Lower limb asymmetry (HP:0100559)1.64372889
123Thickened helices (HP:0000391)1.62943374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.94874412
2NTRK33.91261336
3MARK13.86012585
4MAP3K93.79754992
5PRKD33.63391678
6MINK12.66199072
7MAP3K42.55252502
8DAPK22.48196573
9PAK62.47869197
10NTRK22.34266102
11NTRK12.06977067
12MAP2K72.06938852
13CAMKK12.05483936
14STK381.87991088
15KSR21.70819104
16CDK51.54953271
17PNCK1.54645306
18RIPK41.48467655
19MAP2K41.46756724
20ICK1.46305678
21TYRO31.44415846
22PDK31.42793392
23PDK41.42793392
24TNIK1.39532191
25SIK21.34662485
26MAPK131.34221582
27PRPF4B1.30807886
28PHKG21.27147192
29PHKG11.27147192
30KSR11.24992270
31TESK11.22502693
32GRK51.19716664
33PRKCG1.17750730
34TAOK11.13985851
35UHMK11.12990379
36DAPK11.12713909
37CASK1.11485755
38LATS21.09384637
39STK111.05670001
40PTK2B1.01170900
41FES0.99916191
42MARK20.95404252
43PLK20.94239542
44MAP3K20.94057526
45CDK190.93040007
46LMTK20.92453519
47CDK150.91276298
48CAMK10.90778718
49CDK180.89936832
50PINK10.89624071
51PDK10.86384300
52ALK0.86188842
53PRKCH0.85015989
54CAMK2A0.84013806
55CDK140.83597269
56STK390.82445593
57SGK4940.82435478
58SGK2230.82435478
59MAP3K120.82157873
60MAP3K130.81847924
61WNK10.81500337
62CDK11A0.78861757
63DYRK20.78836910
64RET0.78828664
65PDPK10.74075405
66MAPK120.73769179
67ARAF0.73084195
68CAMKK20.72014375
69FGFR20.71829686
70DYRK1B0.71804026
71PDK20.71075163
72CAMK1G0.70929917
73CAMK1D0.70617220
74NEK60.70309080
75OXSR10.65404622
76WNK40.64285725
77PAK30.64247256
78DYRK1A0.62535034
79CSNK1G20.59094188
80SGK10.58839076
81PRKCZ0.58801894
82CAMK2B0.58683842
83PKN10.58082658
84SGK20.56824172
85SGK30.55913974
86RIPK10.55287395
87CDC42BPA0.52417406
88ERBB20.50956158
89EPHB20.49803137
90BRSK10.48843279
91RPS6KA30.48742222
92FYN0.47770850
93TNK20.46889914
94MAPK100.44341227
95WNK30.43625839
96RAF10.41304136
97MAP3K10.40384265
98LIMK10.37824004
99MAP3K110.36855495
100MAP2K60.36717608
101CAMK40.36256527
102RPS6KA20.35815316
103BMPR20.35325683
104CSNK1E0.34859716
105BRAF0.34826764
106ROCK20.34823751
107CAMK2G0.34791852
108PRKCE0.33907717
109GSK3B0.33437592
110MAP3K70.33079589
111PRKG10.32558559
112CSNK1D0.32338959
113INSRR0.32094203
114DAPK30.30715436
115MAPK80.30592193
116PRKCB0.30331306
117PRKCA0.30247668
118PRKACA0.29164280
119PRKAA10.28857464
120ROCK10.28849348
121CAMK2D0.28834814

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35701840
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14552803
3Olfactory transduction_Homo sapiens_hsa047402.92877147
4Circadian entrainment_Homo sapiens_hsa047132.64852883
5Glutamatergic synapse_Homo sapiens_hsa047242.58286837
6GABAergic synapse_Homo sapiens_hsa047272.53847627
7Long-term potentiation_Homo sapiens_hsa047202.49677090
8Morphine addiction_Homo sapiens_hsa050322.43436553
9Amphetamine addiction_Homo sapiens_hsa050312.42767421
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41509878
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32991403
12Salivary secretion_Homo sapiens_hsa049702.18189053
13Dopaminergic synapse_Homo sapiens_hsa047282.09424145
14Insulin secretion_Homo sapiens_hsa049112.02505189
15Gastric acid secretion_Homo sapiens_hsa049711.94250197
16Cholinergic synapse_Homo sapiens_hsa047251.92417613
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85205135
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73824319
19Taste transduction_Homo sapiens_hsa047421.69062792
20Renin secretion_Homo sapiens_hsa049241.67708773
21Cocaine addiction_Homo sapiens_hsa050301.66116182
22Oxytocin signaling pathway_Homo sapiens_hsa049211.61283067
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56040163
24Calcium signaling pathway_Homo sapiens_hsa040201.55991999
25Long-term depression_Homo sapiens_hsa047301.52651386
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51338590
27Serotonergic synapse_Homo sapiens_hsa047261.45072381
28GnRH signaling pathway_Homo sapiens_hsa049121.36564593
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36397440
30cAMP signaling pathway_Homo sapiens_hsa040241.32311120
31Gap junction_Homo sapiens_hsa045401.30927012
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30573334
33Axon guidance_Homo sapiens_hsa043601.29444745
34Type II diabetes mellitus_Homo sapiens_hsa049301.28267191
35Estrogen signaling pathway_Homo sapiens_hsa049151.26743467
36Dorso-ventral axis formation_Homo sapiens_hsa043201.22336431
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20076070
38Nitrogen metabolism_Homo sapiens_hsa009101.19395186
39Glioma_Homo sapiens_hsa052141.11879536
40Vitamin B6 metabolism_Homo sapiens_hsa007501.09882028
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09212885
42ErbB signaling pathway_Homo sapiens_hsa040121.05571581
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02529745
44Oocyte meiosis_Homo sapiens_hsa041141.01800528
45Melanogenesis_Homo sapiens_hsa049161.01654057
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98498464
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.95305214
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.94006983
49Collecting duct acid secretion_Homo sapiens_hsa049660.91902227
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88749715
51Pancreatic secretion_Homo sapiens_hsa049720.87472149
52Cardiac muscle contraction_Homo sapiens_hsa042600.86558832
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84018703
54Thyroid hormone synthesis_Homo sapiens_hsa049180.82031092
55Phototransduction_Homo sapiens_hsa047440.79109961
56Choline metabolism in cancer_Homo sapiens_hsa052310.75215758
57Glucagon signaling pathway_Homo sapiens_hsa049220.74323595
58MAPK signaling pathway_Homo sapiens_hsa040100.73853713
59Fatty acid biosynthesis_Homo sapiens_hsa000610.71708050
60VEGF signaling pathway_Homo sapiens_hsa043700.69348461
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66819614
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66102056
63Endocytosis_Homo sapiens_hsa041440.65067771
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.65061720
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63499611
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63279425
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63273303
68Ras signaling pathway_Homo sapiens_hsa040140.62404312
69Alcoholism_Homo sapiens_hsa050340.61408120
70Dilated cardiomyopathy_Homo sapiens_hsa054140.61169374
71Bile secretion_Homo sapiens_hsa049760.59550821
72Rap1 signaling pathway_Homo sapiens_hsa040150.59479663
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.57155759
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55195653
75mTOR signaling pathway_Homo sapiens_hsa041500.54929504
76Endometrial cancer_Homo sapiens_hsa052130.53274960
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52555363
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52296596
79Inositol phosphate metabolism_Homo sapiens_hsa005620.50752791
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50030159
81Wnt signaling pathway_Homo sapiens_hsa043100.49387100
82Vibrio cholerae infection_Homo sapiens_hsa051100.48193807
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45807328
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.44703346
85Renal cell carcinoma_Homo sapiens_hsa052110.43067796
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42612581
87Ovarian steroidogenesis_Homo sapiens_hsa049130.42244338
88Insulin signaling pathway_Homo sapiens_hsa049100.41382535
89Non-small cell lung cancer_Homo sapiens_hsa052230.39109101
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37964970
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37481037
92Chemokine signaling pathway_Homo sapiens_hsa040620.37345201
93Type I diabetes mellitus_Homo sapiens_hsa049400.36870326
94Hippo signaling pathway_Homo sapiens_hsa043900.36584176
95AMPK signaling pathway_Homo sapiens_hsa041520.36246090
96Prion diseases_Homo sapiens_hsa050200.34733310
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32020127
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31867880
99Mineral absorption_Homo sapiens_hsa049780.31299530
100Alzheimers disease_Homo sapiens_hsa050100.30465420
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30279435
102Hedgehog signaling pathway_Homo sapiens_hsa043400.30218713
103Tight junction_Homo sapiens_hsa045300.29134946
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28999414
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28548921
106Circadian rhythm_Homo sapiens_hsa047100.28079141
107Arginine biosynthesis_Homo sapiens_hsa002200.25378931
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23139874
109Arginine and proline metabolism_Homo sapiens_hsa003300.22566736
110Histidine metabolism_Homo sapiens_hsa003400.21436569

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