TTC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.86049248
2regulation of B cell receptor signaling pathway (GO:0050855)4.75778075
3response to interleukin-15 (GO:0070672)4.46055519
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30928542
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.30928542
6modulation by symbiont of host immune response (GO:0052553)4.30928542
7positive regulation by symbiont of host defense response (GO:0052509)4.30928542
8modulation by symbiont of host defense response (GO:0052031)4.30928542
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30928542
10activated T cell proliferation (GO:0050798)4.27425336
11negative T cell selection (GO:0043383)4.23725505
12negative thymic T cell selection (GO:0045060)4.17308011
13cellular response to interleukin-15 (GO:0071350)4.12888539
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.03148151
15nuclear pore complex assembly (GO:0051292)3.89549027
16detection of other organism (GO:0098543)3.88339884
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87536449
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87536449
19DNA unwinding involved in DNA replication (GO:0006268)3.86135166
20tetrahydrofolate metabolic process (GO:0046653)3.84589119
21B cell receptor signaling pathway (GO:0050853)3.84447945
22negative regulation of T cell mediated immunity (GO:0002710)3.81270472
23macrophage activation involved in immune response (GO:0002281)3.78580517
24detection of bacterium (GO:0016045)3.65873646
25nuclear pore organization (GO:0006999)3.64928067
26cellular extravasation (GO:0045123)3.63510383
27IMP biosynthetic process (GO:0006188)3.63370561
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.60342606
29T cell selection (GO:0045058)3.49947366
30positive regulation of granulocyte differentiation (GO:0030854)3.46820759
31regulation of interferon-beta biosynthetic process (GO:0045357)3.44716741
32neutrophil activation involved in immune response (GO:0002283)3.42506861
33positive T cell selection (GO:0043368)3.41717031
34negative regulation of leukocyte mediated immunity (GO:0002704)3.39272429
35protein localization to kinetochore (GO:0034501)3.39102122
36detection of external biotic stimulus (GO:0098581)3.37850951
37detection of molecule of bacterial origin (GO:0032490)3.34831402
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.33587414
39folic acid metabolic process (GO:0046655)3.29542146
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28904652
41negative regulation of cell killing (GO:0031342)3.28904652
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.28825245
43positive regulation of mast cell activation (GO:0033005)3.28205240
44negative regulation of erythrocyte differentiation (GO:0045647)3.26496582
45negative regulation of glycoprotein biosynthetic process (GO:0010561)3.26459020
46positive thymic T cell selection (GO:0045059)3.25805485
47T cell migration (GO:0072678)3.24621742
48tolerance induction (GO:0002507)3.18194809
49one-carbon metabolic process (GO:0006730)3.16513997
50positive regulation of gamma-delta T cell activation (GO:0046645)3.16513531
51regulation of mast cell degranulation (GO:0043304)3.15672300
52thymic T cell selection (GO:0045061)3.14965379
53antigen processing and presentation via MHC class Ib (GO:0002475)3.14544678
54regulation of translational fidelity (GO:0006450)3.13329158
55regulation of granulocyte differentiation (GO:0030852)3.12434771
56response to muramyl dipeptide (GO:0032495)3.09055627
57DNA geometric change (GO:0032392)3.07700023
58pore complex assembly (GO:0046931)3.07381947
59IMP metabolic process (GO:0046040)3.06344294
60DNA duplex unwinding (GO:0032508)3.06125705
61folic acid-containing compound metabolic process (GO:0006760)3.05771686
62response to peptidoglycan (GO:0032494)3.05591230
63regulation of defense response to virus by virus (GO:0050690)3.03407042
64antigen processing and presentation of endogenous antigen (GO:0019883)3.02650119
65respiratory burst (GO:0045730)3.02209385
66glycine metabolic process (GO:0006544)3.01104289
67regulation of mast cell activation involved in immune response (GO:0033006)3.00622352
68regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.99716338
69regulation of natural killer cell mediated immunity (GO:0002715)2.99716338
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99100814
71response to host immune response (GO:0052572)2.98528376
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98528376
73regulation of T cell tolerance induction (GO:0002664)2.98488467
74translesion synthesis (GO:0019985)2.98260419
75heterochromatin organization (GO:0070828)2.97294864
76microglial cell activation (GO:0001774)2.96969494
77regulation of B cell differentiation (GO:0045577)2.95662656
783-UTR-mediated mRNA stabilization (GO:0070935)2.95484777
79dosage compensation (GO:0007549)2.95273001
80mitotic nuclear envelope disassembly (GO:0007077)2.94623582
81neutrophil mediated immunity (GO:0002446)2.94511563
82neutrophil activation (GO:0042119)2.94070444
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93701954
84regulation of leukocyte degranulation (GO:0043300)2.92719523
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89182966
86regulation of necroptotic process (GO:0060544)2.89171211
87detection of biotic stimulus (GO:0009595)2.88276118
88histone H3-K9 demethylation (GO:0033169)2.87897793
89positive regulation of B cell differentiation (GO:0045579)2.87521081
90antigen receptor-mediated signaling pathway (GO:0050851)2.85322117
91positive regulation of mast cell activation involved in immune response (GO:0033008)2.84493211
92positive regulation of mast cell degranulation (GO:0043306)2.84493211
93regulation of mast cell activation (GO:0033003)2.84199531
94mitotic chromosome condensation (GO:0007076)2.83296983
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82951075
96positive regulation of cellular amide metabolic process (GO:0034250)2.81664275
97DNA replication initiation (GO:0006270)2.80522136
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79589932
99regulation of amyloid precursor protein catabolic process (GO:1902991)2.78459225
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77774815
101response to host (GO:0075136)2.77774815
102response to host defenses (GO:0052200)2.77774815
103negative regulation of necroptotic process (GO:0060546)2.77266435
104production of molecular mediator involved in inflammatory response (GO:0002532)2.76682537
105B cell homeostasis (GO:0001782)2.76353616
106nuclear envelope disassembly (GO:0051081)2.73967172
107membrane disassembly (GO:0030397)2.73967172
108regulation of tolerance induction (GO:0002643)2.73064202
109T cell proliferation (GO:0042098)2.72657308
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72498352
111positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.72294723
112regulation of beta-amyloid formation (GO:1902003)2.72069875
113T cell receptor signaling pathway (GO:0050852)2.71897311
114regulation of regulatory T cell differentiation (GO:0045589)2.71648525
115DNA strand elongation involved in DNA replication (GO:0006271)2.71432593
116pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.71207945
117germinal center formation (GO:0002467)2.71166674
118regulation of alpha-beta T cell proliferation (GO:0046640)2.70011839
119negative regulation of type 2 immune response (GO:0002829)2.69083460
120regulation of T cell mediated cytotoxicity (GO:0001914)2.67612963
121protein localization to chromosome, centromeric region (GO:0071459)2.63569592
122pteridine-containing compound biosynthetic process (GO:0042559)2.62644111
123regulation of nuclear cell cycle DNA replication (GO:0033262)2.61605789
124low-density lipoprotein particle clearance (GO:0034383)2.59803764
125pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.59715598
126negative regulation of phagocytosis (GO:0050765)2.59350358
127Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58603042
128mitotic G1 DNA damage checkpoint (GO:0031571)2.55963123
129DNA strand elongation (GO:0022616)2.55835655
130regulation of gamma-delta T cell differentiation (GO:0045586)2.52863891
131imidazole-containing compound metabolic process (GO:0052803)2.52246817
132activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.50730901
133negative regulation of mRNA metabolic process (GO:1903312)2.48846672
134negative regulation of mRNA processing (GO:0050686)2.46105302
135negative regulation of RNA splicing (GO:0033119)2.46047631
136nucleobase biosynthetic process (GO:0046112)2.45000158
137pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.44451364
138UMP metabolic process (GO:0046049)2.44451364
139pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.44451364
140UMP biosynthetic process (GO:0006222)2.44451364
141histone mRNA catabolic process (GO:0071044)2.44169719
142telomere maintenance via semi-conservative replication (GO:0032201)2.42928056
143positive regulation of histone deacetylation (GO:0031065)2.42198128
144regulation of protein heterodimerization activity (GO:0043497)2.39708566
145negative regulation of interleukin-12 production (GO:0032695)2.39281734
146mitotic recombination (GO:0006312)2.38577585
147serine family amino acid biosynthetic process (GO:0009070)2.38345202
148regulation of gamma-delta T cell activation (GO:0046643)2.38156555
149regulation of DNA damage checkpoint (GO:2000001)2.36860023
150positive regulation of immune response to tumor cell (GO:0002839)2.36647193
151regulation of immune response to tumor cell (GO:0002837)2.36647193
152regulation of response to tumor cell (GO:0002834)2.36647193
153positive regulation of response to tumor cell (GO:0002836)2.36647193
154urea metabolic process (GO:0019627)2.36553294
155urea cycle (GO:0000050)2.36553294
156regulation of translational termination (GO:0006449)2.36155868
157organ regeneration (GO:0031100)2.32398631
158chromatin assembly (GO:0031497)2.30761751
159pteridine-containing compound metabolic process (GO:0042558)2.28394007
160leukocyte aggregation (GO:0070486)2.28263013
161peptidyl-lysine dimethylation (GO:0018027)2.27427852
162alternative mRNA splicing, via spliceosome (GO:0000380)2.27375796
163alpha-linolenic acid metabolic process (GO:0036109)2.25718675
164telomere maintenance via telomere lengthening (GO:0010833)2.25007930
165telomere maintenance via recombination (GO:0000722)2.24886696
166negative regulation of fibrinolysis (GO:0051918)2.24667561
167regulation of DNA endoreduplication (GO:0032875)2.23294111
168negative regulation of granulocyte differentiation (GO:0030853)2.23249646
169cell adhesion mediated by integrin (GO:0033627)2.23060407
170regulation of telomere maintenance via telomerase (GO:0032210)2.22503338
171regulation of histone H3-K9 methylation (GO:0051570)2.21994109
172necroptotic process (GO:0070266)2.21831150
173positive regulation of endothelial cell apoptotic process (GO:2000353)2.21828771
174DNA conformation change (GO:0071103)2.21770527
175mitotic G1/S transition checkpoint (GO:0044819)2.21547365
176regulation of mitotic spindle organization (GO:0060236)2.21066570
177negative regulation of histone methylation (GO:0031061)2.20185805
178DNA replication checkpoint (GO:0000076)2.20173897
179intestinal cholesterol absorption (GO:0030299)2.19978696
180Golgi transport vesicle coating (GO:0048200)2.18505200
181COPI coating of Golgi vesicle (GO:0048205)2.18505200
182regulation of spindle organization (GO:0090224)2.18183642
183L-alpha-amino acid transmembrane transport (GO:1902475)2.18182853
184tRNA aminoacylation for protein translation (GO:0006418)2.18180247
185nuclear envelope organization (GO:0006998)2.17920639
186L-serine metabolic process (GO:0006563)2.17465935
187antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.16668770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31860738
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.35506997
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.71537988
4MYC_22102868_ChIP-Seq_BL_Human2.99570948
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.95061587
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93843071
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79548427
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75264699
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.73388400
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.72941089
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68911085
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.62738733
13GATA1_22025678_ChIP-Seq_K562_Human2.42985746
14SPI1_23127762_ChIP-Seq_K562_Human2.28049508
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.27353300
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25588218
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23026526
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10353734
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.04448953
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04023275
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03963030
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01130415
23VDR_21846776_ChIP-Seq_THP-1_Human1.94555741
24* MAF_26560356_Chip-Seq_TH2_Human1.90757226
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88960619
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88849550
27* GATA3_27048872_Chip-Seq_THYMUS_Human1.87846707
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80482007
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79728385
30CIITA_25753668_ChIP-Seq_RAJI_Human1.78253292
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75516013
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74865353
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69325350
34* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69223945
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.68014181
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67577289
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67138744
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65456775
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64972899
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62029446
41* GATA1_19941827_ChIP-Seq_MEL_Mouse1.58535107
42PU_27001747_Chip-Seq_BMDM_Mouse1.58241385
43* KDM2B_26808549_Chip-Seq_JURKAT_Human1.57383167
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56105885
45AR_21909140_ChIP-Seq_LNCAP_Human1.55486382
46MYB_26560356_Chip-Seq_TH1_Human1.55000234
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.51244468
48MAF_26560356_Chip-Seq_TH1_Human1.51145889
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50180228
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50006247
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49792540
52TCF7_22412390_ChIP-Seq_EML_Mouse1.48934883
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48568342
54* UTX_26944678_Chip-Seq_JUKART_Human1.48354765
55* MYB_26560356_Chip-Seq_TH2_Human1.46079733
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.45959783
57SCL_19346495_ChIP-Seq_HPC-7_Human1.41991146
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41319336
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40274045
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39317259
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38413324
62* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36930487
63* GATA3_26560356_Chip-Seq_TH2_Human1.35329319
64TFEB_21752829_ChIP-Seq_HELA_Human1.35171557
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33314025
66SPI1_23547873_ChIP-Seq_NB4_Human1.30005456
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.29833795
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27799621
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27701749
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26560335
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26489316
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26009560
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25328172
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24308206
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23632646
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22085209
77* XRN2_22483619_ChIP-Seq_HELA_Human1.21205332
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20913826
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19731282
80VDR_24763502_ChIP-Seq_THP-1_Human1.19146575
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17843975
82RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17702656
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16476542
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16204018
85FOXP3_21729870_ChIP-Seq_TREG_Human1.16156764
86KDM5A_27292631_Chip-Seq_BREAST_Human1.15995251
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15811953
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15749763
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14742308
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13111817
91KDM2B_26808549_Chip-Seq_DND41_Human1.13078968
92* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10982518
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09866473
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08575424
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.06525098
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.06420618
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05714155
98CLOCK_20551151_ChIP-Seq_293T_Human1.05713935
99* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02739817
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02540626
101* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01982915
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01015534
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.99368875
104IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98749409
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97861163
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97718314
107BP1_19119308_ChIP-ChIP_Hs578T_Human0.97512034
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97067445
109GATA2_19941826_ChIP-Seq_K562_Human0.96481763
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.96444247
111VDR_23849224_ChIP-Seq_CD4+_Human0.95892038
112* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95521542
113E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95192169
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94388804
115VDR_24787735_ChIP-Seq_THP-1_Human0.94070477
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93734331
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93685661
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93259360
119* GABP_19822575_ChIP-Seq_HepG2_Human0.92692733
120* DCP1A_22483619_ChIP-Seq_HELA_Human0.91784015
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91295900
122* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91219331
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91208177
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91038933
125RUNX_20019798_ChIP-Seq_JUKART_Human0.90718913
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89898515
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89416226
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88992068
129ATF3_27146783_Chip-Seq_COLON_Human0.88959590
130NCOR1_26117541_ChIP-Seq_K562_Human0.88938575
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88423610
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88010375
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88005729
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87401982
135SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85786936
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85758786
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85686181
138GATA1_19941826_ChIP-Seq_K562_Human0.85161103
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84438585
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84128219
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83215556
142PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78436892
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77087948
144KDM2B_26808549_Chip-Seq_K562_Human0.76855048
145* GATA2_21666600_ChIP-Seq_HMVEC_Human0.73139828
146SMRT_27268052_Chip-Seq_Bcells_Human0.72485139
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71387667
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71155308
149* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70897240
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70053097

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.53163113
2MP0010352_gastrointestinal_tract_polyps3.00455346
3MP0002009_preneoplasia2.94473364
4MP0000569_abnormal_digit_pigmentation2.70894700
5MP0002396_abnormal_hematopoietic_system2.65587351
6MP0003705_abnormal_hypodermis_morpholog2.58617967
7MP0008260_abnormal_autophagy2.57759043
8MP0005365_abnormal_bile_salt2.54673309
9MP0006082_CNS_inflammation2.53322358
10MP0002139_abnormal_hepatobiliary_system2.48763260
11MP0003111_abnormal_nucleus_morphology2.37491008
12MP0010094_abnormal_chromosome_stability2.36898499
13MP0005360_urolithiasis2.15634520
14MP0003693_abnormal_embryo_hatching2.15133262
15MP0003221_abnormal_cardiomyocyte_apopto2.12035955
16MP0000465_gastrointestinal_hemorrhage2.10305335
17MP0010307_abnormal_tumor_latency2.06661377
18MP0005083_abnormal_biliary_tract2.06476108
19MP0003656_abnormal_erythrocyte_physiolo2.04412879
20MP0003828_pulmonary_edema1.95391827
21MP0001986_abnormal_taste_sensitivity1.93199758
22MP0003303_peritoneal_inflammation1.88594126
23MP0003763_abnormal_thymus_physiology1.85743106
24MP0004808_abnormal_hematopoietic_stem1.85646581
25MP0005076_abnormal_cell_differentiation1.85335619
26MP0003436_decreased_susceptibility_to1.79760343
27MP0000858_altered_metastatic_potential1.78834656
28MP0008007_abnormal_cellular_replicative1.77927832
29MP0003300_gastrointestinal_ulcer1.77675859
30MP0003077_abnormal_cell_cycle1.76668412
31MP0000685_abnormal_immune_system1.76375927
32MP0004957_abnormal_blastocyst_morpholog1.73863444
33MP0005085_abnormal_gallbladder_physiolo1.72035737
34MP0001835_abnormal_antigen_presentation1.63845841
35MP0003172_abnormal_lysosome_physiology1.62601659
36MP0000490_abnormal_crypts_of1.60828582
37MP0003566_abnormal_cell_adhesion1.57004857
38MP0002166_altered_tumor_susceptibility1.54407737
39MP0001800_abnormal_humoral_immune1.52983190
40MP0002398_abnormal_bone_marrow1.51071578
41MP0005058_abnormal_lysosome_morphology1.49897882
42MP0004883_abnormal_blood_vessel1.48441725
43MP0001873_stomach_inflammation1.45654494
44MP0005397_hematopoietic_system_phenotyp1.41599723
45MP0001545_abnormal_hematopoietic_system1.41599723
46MP0003252_abnormal_bile_duct1.40598642
47MP0005464_abnormal_platelet_physiology1.40346434
48MP0000689_abnormal_spleen_morphology1.39964570
49MP0009333_abnormal_splenocyte_physiolog1.37756787
50MP0002452_abnormal_antigen_presenting1.37101106
51MP0008438_abnormal_cutaneous_collagen1.37090857
52MP0002006_tumorigenesis1.36548351
53MP0002722_abnormal_immune_system1.36380463
54MP0010329_abnormal_lipoprotein_level1.36233200
55MP0008057_abnormal_DNA_replication1.35716372
56MP0000703_abnormal_thymus_morphology1.35500323
57MP0009840_abnormal_foam_cell1.35485325
58MP0000609_abnormal_liver_physiology1.34519349
59MP0009278_abnormal_bone_marrow1.32994174
60MP0005023_abnormal_wound_healing1.32582329
61MP0000350_abnormal_cell_proliferation1.31265634
62MP0003806_abnormal_nucleotide_metabolis1.29079813
63MP0003866_abnormal_defecation1.29048643
64MP0000371_diluted_coat_color1.28947657
65MP0005451_abnormal_body_composition1.28921130
66MP0003787_abnormal_imprinting1.27616785
67MP0004947_skin_inflammation1.25444533
68MP0002019_abnormal_tumor_incidence1.23997336
69MP0003690_abnormal_glial_cell1.23299693
70MP0002419_abnormal_innate_immunity1.22496724
71MP0003183_abnormal_peptide_metabolism1.21270726
72MP0008058_abnormal_DNA_repair1.21266300
73MP0002420_abnormal_adaptive_immunity1.21222690
74MP0001819_abnormal_immune_cell1.19869879
75MP0005220_abnormal_exocrine_pancreas1.19636184
76MP0000716_abnormal_immune_system1.18474354
77MP0000015_abnormal_ear_pigmentation1.18465278
78MP0001666_abnormal_nutrient_absorption1.16813211
79MP0002723_abnormal_immune_serum1.16414279
80MP0003191_abnormal_cellular_cholesterol1.15998776
81MP0001915_intracranial_hemorrhage1.15919361
82MP0003329_amyloid_beta_deposits1.14724235
83MP0002429_abnormal_blood_cell1.13780749
84MP0010155_abnormal_intestine_physiology1.13386850
85MP0004197_abnormal_fetal_growth/weight/1.12087699
86MP0002405_respiratory_system_inflammati1.11926144
87MP0005310_abnormal_salivary_gland1.10312997
88MP0005387_immune_system_phenotype1.10149272
89MP0001790_abnormal_immune_system1.10149272
90MP0001851_eye_inflammation1.09208175
91MP0005671_abnormal_response_to1.09033187
92MP0001730_embryonic_growth_arrest1.08810050
93MP0002086_abnormal_extraembryonic_tissu1.08417054
94MP0005025_abnormal_response_to1.08100588
95MP0005000_abnormal_immune_tolerance1.07346428
96MP0009785_altered_susceptibility_to1.05641910
97MP0001853_heart_inflammation1.05181026
98MP0000598_abnormal_liver_morphology1.04493940
99MP0003868_abnormal_feces_composition1.04174273
100MP0003091_abnormal_cell_migration1.03533783
101MP0004484_altered_response_of1.03369467
102MP0005670_abnormal_white_adipose1.03048895
103MP0006054_spinal_hemorrhage1.02954189
104MP0003448_altered_tumor_morphology1.01126322
105MP0000604_amyloidosis1.00944055
106MP0002089_abnormal_postnatal_growth/wei1.00683836
107MP0002877_abnormal_melanocyte_morpholog1.00166227
108MP0000733_abnormal_muscle_development1.00078251
109MP0003045_fibrosis0.98081647
110MP0003123_paternal_imprinting0.97590797
111MP0000013_abnormal_adipose_tissue0.96644835
112MP0001845_abnormal_inflammatory_respons0.94652127
113MP0009672_abnormal_birth_weight0.94633900
114MP0009763_increased_sensitivity_to0.93747197
115MP0001672_abnormal_embryogenesis/_devel0.92653830
116MP0005380_embryogenesis_phenotype0.92653830
117MP0000537_abnormal_urethra_morphology0.91516480
118MP0002088_abnormal_embryonic_growth/wei0.90708345
119MP0002080_prenatal_lethality0.90173587
120MP0005174_abnormal_tail_pigmentation0.90168657
121MP0003984_embryonic_growth_retardation0.90013955
122MP0001533_abnormal_skeleton_physiology0.88856203
123MP0005164_abnormal_response_to0.87569062
124MP0002332_abnormal_exercise_endurance0.87438047
125MP0008004_abnormal_stomach_pH0.86581871
126MP0002148_abnormal_hypersensitivity_rea0.85164262
127MP0005621_abnormal_cell_physiology0.83607958
128MP0008469_abnormal_protein_level0.82054894
129MP0008961_abnormal_basal_metabolism0.80052218
130MP0009053_abnormal_anal_canal0.80043724
131MP0004381_abnormal_hair_follicle0.78149932
132MP0004130_abnormal_muscle_cell0.76148201
133MP0005166_decreased_susceptibility_to0.74124664
134MP0003646_muscle_fatigue0.73027185
135MP0008874_decreased_physiological_sensi0.72106335
136MP0005384_cellular_phenotype0.70444458
137MP0005075_abnormal_melanosome_morpholog0.69577422
138MP0004185_abnormal_adipocyte_glucose0.68964326
139MP0002998_abnormal_bone_remodeling0.68198424
140MP0001270_distended_abdomen0.66641581
141MP0009764_decreased_sensitivity_to0.65967212
142MP0003632_abnormal_nervous_system0.65411313
143MP0005645_abnormal_hypothalamus_physiol0.59617462
144MP0004811_abnormal_neuron_physiology0.59461186
145MP0004233_abnormal_muscle_weight0.58119550
146MP0005376_homeostasis/metabolism_phenot0.56053171
147MP0000249_abnormal_blood_vessel0.53630426
148MP0002928_abnormal_bile_duct0.53533183

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.88427496
2Spontaneous hematomas (HP:0007420)3.84610094
3Gastrointestinal infarctions (HP:0005244)3.70803651
4Abnormality of macrophages (HP:0004311)3.36126873
5Recurrent skin infections (HP:0001581)3.19047317
6Mediastinal lymphadenopathy (HP:0100721)3.10692935
7Myositis (HP:0100614)3.10675887
8Abnormal platelet volume (HP:0011876)3.06729916
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05163008
10Increased mean platelet volume (HP:0011877)2.99787701
11Gingivitis (HP:0000230)2.97560405
12Meningitis (HP:0001287)2.82717746
13Retrobulbar optic neuritis (HP:0100654)2.81600311
14Optic neuritis (HP:0100653)2.81600311
15Orchitis (HP:0100796)2.72366364
16Encephalitis (HP:0002383)2.62989659
17Urticaria (HP:0001025)2.60755465
18Stomatitis (HP:0010280)2.59512078
19Recurrent viral infections (HP:0004429)2.59039372
20Abnormality of pyrimidine metabolism (HP:0004353)2.53328011
21Vasculitis (HP:0002633)2.51641478
22Chest pain (HP:0100749)2.51328722
23Spastic diplegia (HP:0001264)2.48736814
24T lymphocytopenia (HP:0005403)2.42453895
25Slow saccadic eye movements (HP:0000514)2.42166226
26Lower limb hyperreflexia (HP:0002395)2.39343594
27Acute hepatic failure (HP:0006554)2.37551162
28Cellulitis (HP:0100658)2.34236293
29Chronic obstructive pulmonary disease (HP:0006510)2.33688339
30Obstructive lung disease (HP:0006536)2.33688339
31Fatigue (HP:0012378)2.33262137
32Abnormality of the thoracic spine (HP:0100711)2.30272649
33Deep venous thrombosis (HP:0002625)2.30033431
34Papilledema (HP:0001085)2.28668817
35Abnormality of T cells (HP:0002843)2.26011226
36Panhypogammaglobulinemia (HP:0003139)2.25838543
37Selective tooth agenesis (HP:0001592)2.25061571
38IgM deficiency (HP:0002850)2.24776003
39Osteomyelitis (HP:0002754)2.24408290
40Mucopolysacchariduria (HP:0008155)2.24034798
41Urinary glycosaminoglycan excretion (HP:0003541)2.24034798
42Amyotrophic lateral sclerosis (HP:0007354)2.23501087
43Thrombocytosis (HP:0001894)2.22728903
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21527782
45Abnormality of polysaccharide metabolism (HP:0011012)2.21527782
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21527782
47Ankle clonus (HP:0011448)2.20987160
48Abnormality of T cell number (HP:0011839)2.20424274
49Keratoconjunctivitis sicca (HP:0001097)2.18505408
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.17994671
51Cervical subluxation (HP:0003308)2.16114959
52Dysostosis multiplex (HP:0000943)2.15906031
53Papillary thyroid carcinoma (HP:0002895)2.14642102
54Global brain atrophy (HP:0002283)2.13202849
55Hepatitis (HP:0012115)2.11632038
56Protrusio acetabuli (HP:0003179)2.11211849
57Elevated erythrocyte sedimentation rate (HP:0003565)2.10572886
58Dilatation of the ascending aorta (HP:0005111)2.09252385
59Lymphopenia (HP:0001888)2.08287457
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07923702
61Myocardial infarction (HP:0001658)2.07824452
62Birth length less than 3rd percentile (HP:0003561)2.06980077
63Chromsome breakage (HP:0040012)2.06799734
64Sparse lateral eyebrow (HP:0005338)2.06624460
65Recurrent fungal infections (HP:0002841)2.06227556
66Upper motor neuron abnormality (HP:0002127)2.06078004
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.03875587
68Papilloma (HP:0012740)2.02317167
69Verrucae (HP:0200043)2.02317167
70Hyperacusis (HP:0010780)2.01453172
71Polycythemia (HP:0001901)2.00659115
72Deviation of the thumb (HP:0009603)2.00357485
73Resting tremor (HP:0002322)1.99997448
74Ureteral obstruction (HP:0006000)1.99583783
75Abnormality of T cell physiology (HP:0011840)1.99100432
76Pulmonary embolism (HP:0002204)1.98798926
77Increased density of long bones (HP:0006392)1.98664327
78Cerebral aneurysm (HP:0004944)1.96478126
79Radial bowing (HP:0002986)1.94561878
80Recurrent gram-negative bacterial infections (HP:0005420)1.94320071
81Subacute progressive viral hepatitis (HP:0006572)1.92795792
82Hypochromic microcytic anemia (HP:0004840)1.92286015
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.92021403
84Hemoptysis (HP:0002105)1.91729073
85Periodontitis (HP:0000704)1.91550508
86Chronic diarrhea (HP:0002028)1.91535007
87Hypobetalipoproteinemia (HP:0003563)1.91265529
88Ureteral stenosis (HP:0000071)1.91236451
89Pheochromocytoma (HP:0002666)1.90721324
90Genu recurvatum (HP:0002816)1.90553789
91Abnormality of the fingertips (HP:0001211)1.90196972
92Microcytic anemia (HP:0001935)1.90088051
93Lip pit (HP:0100267)1.89801568
94Scanning speech (HP:0002168)1.88861407
95Viral hepatitis (HP:0006562)1.87933127
96Keratoconjunctivitis (HP:0001096)1.87300448
97Pulmonary infiltrates (HP:0002113)1.86171704
98Aortic aneurysm (HP:0004942)1.85877116
99Gingival bleeding (HP:0000225)1.85482666
100Chronic otitis media (HP:0000389)1.85255902
101Peritonitis (HP:0002586)1.85203016
102Granulocytopenia (HP:0001913)1.84543557
103Combined immunodeficiency (HP:0005387)1.83101638
104Ependymoma (HP:0002888)1.83090827
105Proximal placement of thumb (HP:0009623)1.82738618
106Urinary urgency (HP:0000012)1.82692198
107Gastrointestinal stroma tumor (HP:0100723)1.81895187
108Progressive neurologic deterioration (HP:0002344)1.81791322
109Thickened calvaria (HP:0002684)1.81692065
110Abnormality of the common coagulation pathway (HP:0010990)1.81673348
111Hypoglycemic seizures (HP:0002173)1.81523556
112Absent speech (HP:0001344)1.80227519
113Gastrointestinal inflammation (HP:0004386)1.79992734
114Leukocytosis (HP:0001974)1.79476322
115Colitis (HP:0002583)1.79436005
116Renovascular hypertension (HP:0100817)1.79324380
117Bowel diverticulosis (HP:0005222)1.78456196
118Mitral valve prolapse (HP:0001634)1.78280281
119Joint swelling (HP:0001386)1.77400892
120Ankle contracture (HP:0006466)1.75453482
121Chronic mucocutaneous candidiasis (HP:0002728)1.75153745
122Recurrent cutaneous fungal infections (HP:0011370)1.75153745
123Amaurosis fugax (HP:0100576)1.74853103
124Ectopia lentis (HP:0001083)1.74488677
125Increased IgE level (HP:0003212)1.73372959
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72879704
127Basal cell carcinoma (HP:0002671)1.72868093
128Arterial thrombosis (HP:0004420)1.72511681
129Inflammation of the large intestine (HP:0002037)1.71210777
130Abnormality of sulfur amino acid metabolism (HP:0004339)1.70205548
131Neuronal loss in central nervous system (HP:0002529)1.69858902
132Abnormality of the astrocytes (HP:0100707)1.69606324
133Astrocytoma (HP:0009592)1.69606324
134Difficulty running (HP:0009046)1.69317205
135Epistaxis (HP:0000421)1.69013619
136Autoimmune thrombocytopenia (HP:0001973)1.68353936
137Shallow orbits (HP:0000586)1.67231710
138IgA deficiency (HP:0002720)1.66944161
139Xanthomatosis (HP:0000991)1.66459463
140Thoracic kyphosis (HP:0002942)1.66088421
141Abnormal foot bone ossification (HP:0010675)1.66077189
142Prominent nose (HP:0000448)1.65026729
143Abnormality of the calcaneus (HP:0008364)1.64378310
144Elfin facies (HP:0004428)1.64070552
145Intrahepatic cholestasis (HP:0001406)1.63652742
146Pseudobulbar signs (HP:0002200)1.62911264
147Hypoplasia of the thymus (HP:0000778)1.62561973
148Severe combined immunodeficiency (HP:0004430)1.61591470
149Abnormality of the lower motor neuron (HP:0002366)1.61398099
150Menorrhagia (HP:0000132)1.59692288
151Flat acetabular roof (HP:0003180)1.59644087
152Pustule (HP:0200039)1.59534684
153Absent frontal sinuses (HP:0002688)1.59269700
154Prolonged bleeding time (HP:0003010)1.58198386
155Oral leukoplakia (HP:0002745)1.57943248
156Joint hemorrhage (HP:0005261)1.57116700
157Interstitial pulmonary disease (HP:0006530)1.56296884
158Frequent falls (HP:0002359)1.56233205
159Severe short stature (HP:0003510)1.56181878
160Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55806683
161Short 4th metacarpal (HP:0010044)1.55806683
162Abnormality of the intrinsic pathway (HP:0010989)1.55475939
16311 pairs of ribs (HP:0000878)1.55222867
164High pitched voice (HP:0001620)1.54224200
165Complement deficiency (HP:0004431)1.53967252
166Recurrent bronchitis (HP:0002837)1.53790875
167Cutaneous melanoma (HP:0012056)1.52859292
168Agnosia (HP:0010524)1.52837990
169Eczematoid dermatitis (HP:0000976)1.52698120
170Abnormality of the peritoneum (HP:0002585)1.51624666
171Disinhibition (HP:0000734)1.50480709
172Recurrent bacterial skin infections (HP:0005406)1.49905239
173Abnormality of the anterior horn cell (HP:0006802)1.48612473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.43780939
2RIPK43.26486125
3EEF2K3.11026155
4CDK122.92456324
5PRPF4B2.69392895
6MAP4K12.60751249
7TRIB32.58436886
8FES2.48881323
9MAP3K102.37529117
10FLT32.29992683
11SIK32.24970726
12STK102.23587689
13CDC72.20944983
14SIK12.06136888
15EPHA22.02024765
16CAMKK21.99058467
17JAK31.93015115
18MAP3K61.88717342
19ACVR1B1.81246092
20KSR21.78100002
21ZAP701.73617534
22MAP3K21.69974993
23MAP3K31.68918719
24YES11.67139896
25TTN1.65831233
26TAOK31.52270481
27MAP3K131.51247911
28RPS6KB21.51245920
29STK241.49612573
30ERN11.47802289
31WEE11.44383503
32SIK21.42683616
33TYK21.41353326
34FGFR41.39171504
35FGR1.39007556
36CCNB11.37688635
37ATR1.36182717
38NEK21.34502076
39KSR11.34475147
40IRAK41.33528028
41MAP3K81.30452348
42RPS6KA41.29958445
43CAMK1D1.29364263
44BCR1.28401012
45TXK1.27050354
46PTK61.24534567
47GRK61.23115923
48RIPK11.22986827
49ERBB31.22724395
50CDK41.20931735
51CDK71.20683031
52CDK61.18338469
53BRD41.13584956
54PASK1.13270838
55LRRK21.12024719
56MAP3K51.09548566
57LYN1.06859607
58IRAK31.05594393
59BLK1.03153600
60ITK1.00483687
61BMPR20.99685466
62TAOK10.98000958
63SCYL20.95872959
64BTK0.94958084
65TGFBR10.94938763
66MTOR0.94922690
67ALK0.94818564
68PIM20.93885074
69MAP2K40.93100641
70MAPKAPK30.91243531
71MARK20.91078394
72TNK20.89689407
73JAK10.89431073
74TRPM70.88693643
75DYRK1B0.88141060
76MAP3K140.88128174
77NME20.86832454
78CAMKK10.84834933
79PAK20.83670903
80PIM10.83475401
81PDK10.82609218
82PAK40.81228008
83TEC0.80171125
84MAP3K40.78915883
85PDGFRA0.77152842
86CSF1R0.76998155
87TTK0.76933117
88TRIM280.74291012
89WNK10.73911845
90EPHB10.73192490
91AURKB0.72571944
92CSK0.71808809
93FGFR10.70932177
94RET0.70304914
95CHUK0.70248255
96EPHA30.69813708
97KIT0.69647387
98LCK0.69568179
99MAPK120.68990086
100BCKDK0.68895147
101MARK30.68080211
102MAP3K10.68071325
103TBK10.66946183
104PDGFRB0.66763784
105HCK0.66513470
106EIF2AK10.65821472
107NEK90.65459323
108MAPK110.65179051
109PLK10.64689870
110CAMK40.64602962
111IKBKE0.63594372
112STK40.61481146
113TESK20.61264527
114CHEK10.60959405
115MAP2K70.60805226
116EIF2AK20.60796028
117MAP2K30.59118868
118TGFBR20.58794063
119CDK190.58141527
120ATM0.57902304
121PIK3CG0.57718320
122PINK10.57266234
123FYN0.55880991
124RAF10.55645774
125FGFR30.54882481
126SYK0.54878070
127RPS6KB10.51859818
128TAOK20.51102467
129MAP3K70.50256547
130NTRK20.49666515
131PDPK10.49639508
132DAPK10.48881953
133EGFR0.48391065
134PTK20.48036992
135JAK20.47798266
136SRPK10.47583491
137BMX0.47557019
138RPS6KL10.47280964
139RPS6KC10.47280964
140CDC42BPA0.47103625
141CDK20.45674547
142MAPK70.45567537
143PRKCQ0.44757822
144CLK10.44346162
145CASK0.44204952
146TSSK60.44026943
147IRAK20.43382289
148NEK10.42849284
149CAMK1G0.41312646
150EIF2AK30.40506485
151IKBKB0.40200355
152TESK10.40112308
153STK380.39173865
154GRK70.37638528
155SGK30.35087657
156IRAK10.33500533
157CDK30.32399304
158RPS6KA60.32057486

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.62366936
2DNA replication_Homo sapiens_hsa030302.75189311
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58284418
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18989070
5Mismatch repair_Homo sapiens_hsa034301.95662682
6Primary immunodeficiency_Homo sapiens_hsa053401.84724222
7Base excision repair_Homo sapiens_hsa034101.76848110
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.59911144
9Graft-versus-host disease_Homo sapiens_hsa053321.50726602
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47706740
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47328592
12Cell cycle_Homo sapiens_hsa041101.47109038
13Lysine degradation_Homo sapiens_hsa003101.45509331
14Selenocompound metabolism_Homo sapiens_hsa004501.45155987
15Renal cell carcinoma_Homo sapiens_hsa052111.44651397
16Staphylococcus aureus infection_Homo sapiens_hsa051501.43801653
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42856215
18Chemokine signaling pathway_Homo sapiens_hsa040621.40302336
19Allograft rejection_Homo sapiens_hsa053301.40131628
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.39680050
21p53 signaling pathway_Homo sapiens_hsa041151.39445532
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.35743088
23Non-homologous end-joining_Homo sapiens_hsa034501.35341181
24Type I diabetes mellitus_Homo sapiens_hsa049401.35103643
25Other glycan degradation_Homo sapiens_hsa005111.32044031
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29648068
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29251442
28Small cell lung cancer_Homo sapiens_hsa052221.28581615
29Arginine biosynthesis_Homo sapiens_hsa002201.28243900
30Chronic myeloid leukemia_Homo sapiens_hsa052201.27853744
31Complement and coagulation cascades_Homo sapiens_hsa046101.27703534
32Autoimmune thyroid disease_Homo sapiens_hsa053201.27623852
33Phagosome_Homo sapiens_hsa041451.24207463
34Systemic lupus erythematosus_Homo sapiens_hsa053221.23389385
35Measles_Homo sapiens_hsa051621.22488302
36Leishmaniasis_Homo sapiens_hsa051401.21091520
37Antigen processing and presentation_Homo sapiens_hsa046121.20877609
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20826539
39RNA transport_Homo sapiens_hsa030131.19522066
40Spliceosome_Homo sapiens_hsa030401.16321091
41Acute myeloid leukemia_Homo sapiens_hsa052211.13102275
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12987006
43Nitrogen metabolism_Homo sapiens_hsa009101.12194219
44Viral carcinogenesis_Homo sapiens_hsa052031.11904798
45VEGF signaling pathway_Homo sapiens_hsa043701.10958659
46Inositol phosphate metabolism_Homo sapiens_hsa005621.09512284
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09074050
48Legionellosis_Homo sapiens_hsa051341.08529710
49Sphingolipid signaling pathway_Homo sapiens_hsa040711.08295889
50Apoptosis_Homo sapiens_hsa042101.05596741
51B cell receptor signaling pathway_Homo sapiens_hsa046621.03661816
52HTLV-I infection_Homo sapiens_hsa051661.02772953
53Nucleotide excision repair_Homo sapiens_hsa034201.02743792
54Prolactin signaling pathway_Homo sapiens_hsa049171.00717656
55Herpes simplex infection_Homo sapiens_hsa051680.99223942
56Hepatitis B_Homo sapiens_hsa051610.96711176
57MicroRNAs in cancer_Homo sapiens_hsa052060.95915968
58T cell receptor signaling pathway_Homo sapiens_hsa046600.94217384
59FoxO signaling pathway_Homo sapiens_hsa040680.93231947
60Fatty acid biosynthesis_Homo sapiens_hsa000610.92990491
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92790909
62Malaria_Homo sapiens_hsa051440.92512543
63Caffeine metabolism_Homo sapiens_hsa002320.92301764
64Glioma_Homo sapiens_hsa052140.92281013
65Salmonella infection_Homo sapiens_hsa051320.91702584
66Colorectal cancer_Homo sapiens_hsa052100.91107921
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90505327
68Endocytosis_Homo sapiens_hsa041440.90475215
69Osteoclast differentiation_Homo sapiens_hsa043800.89881076
70Hepatitis C_Homo sapiens_hsa051600.89308322
71Viral myocarditis_Homo sapiens_hsa054160.88968689
72Choline metabolism in cancer_Homo sapiens_hsa052310.87459627
73Homologous recombination_Homo sapiens_hsa034400.87134402
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85038162
75Long-term potentiation_Homo sapiens_hsa047200.84861285
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84693094
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.84098527
78Pancreatic cancer_Homo sapiens_hsa052120.83496854
79N-Glycan biosynthesis_Homo sapiens_hsa005100.82472688
80Fanconi anemia pathway_Homo sapiens_hsa034600.82396951
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81912397
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81866876
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81553855
84Pertussis_Homo sapiens_hsa051330.81034171
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80132344
86ErbB signaling pathway_Homo sapiens_hsa040120.79993905
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79686832
88Type II diabetes mellitus_Homo sapiens_hsa049300.78225632
89Hematopoietic cell lineage_Homo sapiens_hsa046400.78094982
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77013403
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76671628
92Biosynthesis of amino acids_Homo sapiens_hsa012300.76435044
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.76023847
94Non-small cell lung cancer_Homo sapiens_hsa052230.75177796
95mTOR signaling pathway_Homo sapiens_hsa041500.74719819
96Pyrimidine metabolism_Homo sapiens_hsa002400.74387054
97Toxoplasmosis_Homo sapiens_hsa051450.74106274
98GnRH signaling pathway_Homo sapiens_hsa049120.73310895
99TNF signaling pathway_Homo sapiens_hsa046680.72418830
100Influenza A_Homo sapiens_hsa051640.70547758
101Endometrial cancer_Homo sapiens_hsa052130.68691690
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.68042425
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67411345
104Insulin signaling pathway_Homo sapiens_hsa049100.66682942
105Bladder cancer_Homo sapiens_hsa052190.66555291
106Tryptophan metabolism_Homo sapiens_hsa003800.66190163
107mRNA surveillance pathway_Homo sapiens_hsa030150.65900136
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.65362401
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65237645
110ABC transporters_Homo sapiens_hsa020100.65113184
111Shigellosis_Homo sapiens_hsa051310.64882002
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64517917
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.63529561
114AMPK signaling pathway_Homo sapiens_hsa041520.63234731
115Thyroid cancer_Homo sapiens_hsa052160.63045985
116Folate biosynthesis_Homo sapiens_hsa007900.62973571
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62266786
118Fat digestion and absorption_Homo sapiens_hsa049750.62024337
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61506537
120Epstein-Barr virus infection_Homo sapiens_hsa051690.61375498
121Insulin resistance_Homo sapiens_hsa049310.60625465
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60314432
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58642818
124Pentose phosphate pathway_Homo sapiens_hsa000300.58315547
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.58184791
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.57685630
127Proteoglycans in cancer_Homo sapiens_hsa052050.57543889
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56762244
129Dorso-ventral axis formation_Homo sapiens_hsa043200.56505117
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56255627
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56041068
132Notch signaling pathway_Homo sapiens_hsa043300.55795594
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55578398
134Starch and sucrose metabolism_Homo sapiens_hsa005000.55408099
135Lysosome_Homo sapiens_hsa041420.54876679
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.54461659
137Fatty acid degradation_Homo sapiens_hsa000710.54129007
138Estrogen signaling pathway_Homo sapiens_hsa049150.54092516
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53069455
140Adherens junction_Homo sapiens_hsa045200.53018053
141Asthma_Homo sapiens_hsa053100.52829369
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51721103
143Platelet activation_Homo sapiens_hsa046110.51369619
144PPAR signaling pathway_Homo sapiens_hsa033200.51320062
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49064854
146Tuberculosis_Homo sapiens_hsa051520.48914917
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.48451384
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47599045
149Prostate cancer_Homo sapiens_hsa052150.47222553
150Vitamin digestion and absorption_Homo sapiens_hsa049770.46555076
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.46536847
152Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45430653
153HIF-1 signaling pathway_Homo sapiens_hsa040660.44645253
154MAPK signaling pathway_Homo sapiens_hsa040100.44597859
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43634225

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