TTC14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.70452217
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.42331491
3glutamate receptor signaling pathway (GO:0007215)5.41397411
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.33657882
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09753621
6locomotory exploration behavior (GO:0035641)4.87583151
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75044122
8vocalization behavior (GO:0071625)4.71953338
9glutamate secretion (GO:0014047)4.70444723
10G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.69699431
11synaptic transmission, glutamatergic (GO:0035249)4.64661800
12neuronal action potential propagation (GO:0019227)4.55855336
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52658926
14neural tube formation (GO:0001841)4.50827718
15monoubiquitinated protein deubiquitination (GO:0035520)4.50050081
16regulation of glutamate receptor signaling pathway (GO:1900449)4.46633390
17regulation of B cell receptor signaling pathway (GO:0050855)4.43895687
18neuron-neuron synaptic transmission (GO:0007270)4.39445898
19neuron cell-cell adhesion (GO:0007158)4.37520806
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37299992
21cilium or flagellum-dependent cell motility (GO:0001539)4.32723329
22protein localization to synapse (GO:0035418)4.31774042
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.26965910
24synaptic vesicle exocytosis (GO:0016079)4.25272227
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.24095144
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.13232281
27protein targeting to lysosome (GO:0006622)4.05654175
28establishment of protein localization to vacuole (GO:0072666)4.05654175
29protein targeting to vacuole (GO:0006623)4.05654175
30regulation of synaptic vesicle exocytosis (GO:2000300)4.02950000
31establishment of protein localization to Golgi (GO:0072600)4.00744520
32long-term memory (GO:0007616)3.95351899
33synaptic vesicle maturation (GO:0016188)3.93794639
34cellular potassium ion homeostasis (GO:0030007)3.92061978
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91795259
36presynaptic membrane assembly (GO:0097105)3.89899926
37neuron recognition (GO:0008038)3.88656585
38positive regulation of granulocyte differentiation (GO:0030854)3.86178458
39neurotransmitter-gated ion channel clustering (GO:0072578)3.85543678
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.79337356
41transmission of nerve impulse (GO:0019226)3.78630465
42positive regulation of gamma-delta T cell activation (GO:0046645)3.77010883
43regulation of postsynaptic membrane potential (GO:0060078)3.76699578
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.74128604
45neurotransmitter secretion (GO:0007269)3.73625667
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.71475703
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69333336
48protein targeting to Golgi (GO:0000042)3.68200673
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.68116208
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66225555
51interkinetic nuclear migration (GO:0022027)3.66191504
52exploration behavior (GO:0035640)3.65848235
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64410897
54cerebellar Purkinje cell differentiation (GO:0021702)3.64115680
55long-term synaptic potentiation (GO:0060291)3.62473092
56regulation of neuronal synaptic plasticity (GO:0048168)3.62361465
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.61165682
58regulation of synaptic vesicle transport (GO:1902803)3.58281752
59activated T cell proliferation (GO:0050798)3.57868347
60negative regulation of cell killing (GO:0031342)3.55435087
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.55435087
62presynaptic membrane organization (GO:0097090)3.53419677
63gamma-aminobutyric acid transport (GO:0015812)3.52558107
64regulation of dendritic spine morphogenesis (GO:0061001)3.48754188
65membrane depolarization during action potential (GO:0086010)3.45824857
66axonal fasciculation (GO:0007413)3.45748465
67histone H3-K9 methylation (GO:0051567)3.42135017
68response to histamine (GO:0034776)3.40787889
69peptidyl-lysine trimethylation (GO:0018023)3.40723363
70retrograde transport, vesicle recycling within Golgi (GO:0000301)3.40331606
71epithelial cilium movement (GO:0003351)3.39174920
72positive regulation of dendritic spine development (GO:0060999)3.38681812
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36956877
74cellular response to ethanol (GO:0071361)3.36734414
75regulation of respiratory system process (GO:0044065)3.36447266
76membrane depolarization (GO:0051899)3.33185956
77positive regulation of membrane potential (GO:0045838)3.33130800
78cerebellar granule cell differentiation (GO:0021707)3.31270366
79layer formation in cerebral cortex (GO:0021819)3.31245542
80startle response (GO:0001964)3.31028061
81regulation of vesicle fusion (GO:0031338)3.29931457
82dendritic spine morphogenesis (GO:0060997)3.28954900
83centriole replication (GO:0007099)3.28381431
84neurotransmitter transport (GO:0006836)3.26360966
85regulation of dendritic spine development (GO:0060998)3.23159791
86regulation of synaptic plasticity (GO:0048167)3.21783435
87forebrain morphogenesis (GO:0048853)3.21418700
88cilium movement (GO:0003341)3.21337941
89behavioral defense response (GO:0002209)3.21211411
90behavioral fear response (GO:0001662)3.21211411
91negative thymic T cell selection (GO:0045060)3.20958660
92positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.15351760
93B cell receptor signaling pathway (GO:0050853)3.15033299
94negative T cell selection (GO:0043383)3.14225396
95sodium ion export (GO:0071436)3.13081235
96mRNA splice site selection (GO:0006376)3.12031742
97positive regulation of synapse maturation (GO:0090129)3.11600066
98synaptic vesicle endocytosis (GO:0048488)3.11493647
99postsynaptic membrane organization (GO:0001941)3.10265923
100histone H3-K9 modification (GO:0061647)3.08560599
101regulation of neurotransmitter secretion (GO:0046928)3.08119357
102positive regulation of neurotransmitter secretion (GO:0001956)3.06713716
103fear response (GO:0042596)3.06596646
104positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06237430
105L-amino acid import (GO:0043092)3.05619439
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05446800
107learning (GO:0007612)2.99346559
108suckling behavior (GO:0001967)2.98805726
109protein localization to Golgi apparatus (GO:0034067)2.97466263
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.96117991
111positive regulation of developmental pigmentation (GO:0048087)2.94529398
112regulation of pigment cell differentiation (GO:0050932)2.92804161
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91795705
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.91795705
115regulation of translation, ncRNA-mediated (GO:0045974)2.91795705
116detection of calcium ion (GO:0005513)2.91701217
117auditory behavior (GO:0031223)2.91542345
118regulation of neurotransmitter levels (GO:0001505)2.91473163
119regulation of respiratory gaseous exchange (GO:0043576)2.91195149
120histone mRNA catabolic process (GO:0071044)2.90818496
121regulation of gamma-delta T cell differentiation (GO:0045586)2.89827201
122mechanosensory behavior (GO:0007638)2.89193042
123adult walking behavior (GO:0007628)2.88542045
124histone H3-K4 trimethylation (GO:0080182)2.88125140
125membrane hyperpolarization (GO:0060081)2.86695259
126regulation of gamma-delta T cell activation (GO:0046643)2.85187145
127synapse assembly (GO:0007416)2.84113205
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83143494
129proline transport (GO:0015824)2.83079085
130synaptic transmission (GO:0007268)2.83034300
131dendrite morphogenesis (GO:0048813)2.82021550
132central nervous system projection neuron axonogenesis (GO:0021952)2.81788925
133righting reflex (GO:0060013)2.81650789
134innervation (GO:0060384)2.79834606
135positive regulation of B cell differentiation (GO:0045579)2.79146914
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76359618
137mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.76334219
138positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.76334219
139positive regulation of synaptic transmission (GO:0050806)2.75615035
140regulation of neurotransmitter transport (GO:0051588)2.75564810
141regulation of B cell differentiation (GO:0045577)2.75160060
142regulation of synaptic transmission (GO:0050804)2.74721040
143response to auditory stimulus (GO:0010996)2.74540662
144Golgi to endosome transport (GO:0006895)2.74086529
145positive regulation of neurotransmitter transport (GO:0051590)2.73621271
146positive T cell selection (GO:0043368)2.73331785
147neuronal ion channel clustering (GO:0045161)2.72849694
148histone H3-K9 demethylation (GO:0033169)2.72824024
149axoneme assembly (GO:0035082)2.71760062
150cell differentiation in hindbrain (GO:0021533)2.71218101
151protein prenylation (GO:0018342)2.71116279
152prenylation (GO:0097354)2.71116279
153microtubule anchoring (GO:0034453)2.70331755
154negative regulation of neurotransmitter transport (GO:0051589)2.68628598
155mast cell degranulation (GO:0043303)2.68057337
156mast cell activation involved in immune response (GO:0002279)2.68057337
157negative regulation of T cell mediated immunity (GO:0002710)2.67323447
158protein K11-linked deubiquitination (GO:0035871)2.63834944
159axonemal dynein complex assembly (GO:0070286)2.62294589
160peptidyl-lysine methylation (GO:0018022)2.60603583
161neutrophil mediated immunity (GO:0002446)2.60317512
162negative regulation of B cell proliferation (GO:0030889)2.58378451
163nucleus localization (GO:0051647)2.55304609
164definitive hemopoiesis (GO:0060216)2.53007313
165intraciliary transport (GO:0042073)2.52559656
166microglial cell activation (GO:0001774)2.52094520
167regulation of protein glycosylation (GO:0060049)2.52022383
168negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.51614151
169dentate gyrus development (GO:0021542)2.51108411
170brain morphogenesis (GO:0048854)2.50915247
171protein localization to lysosome (GO:0061462)2.49918638
172protein localization to vacuole (GO:0072665)2.49918638
173myeloid leukocyte mediated immunity (GO:0002444)2.49590887
174glycoprotein catabolic process (GO:0006516)2.46670775
175cilium morphogenesis (GO:0060271)2.45955171
176mast cell activation (GO:0045576)2.45807949
177pyrimidine nucleobase catabolic process (GO:0006208)2.45463304
178cilium organization (GO:0044782)2.44238466
179protein localization to cilium (GO:0061512)2.43551032
180cilium assembly (GO:0042384)2.42163488
181negative regulation of lymphocyte mediated immunity (GO:0002707)2.41373811
182negative regulation of adaptive immune response (GO:0002820)2.39410816
183prostate gland growth (GO:0060736)2.39368760
184positive regulation of growth hormone secretion (GO:0060124)2.39055240
185regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.38830654
186B cell differentiation (GO:0030183)2.38129594
187histone H3-K4 methylation (GO:0051568)2.38054306
188regulation of germinal center formation (GO:0002634)2.37801708
189one-carbon compound transport (GO:0019755)2.37165374
190response to interleukin-15 (GO:0070672)2.35655103
191negative regulation of neurotransmitter secretion (GO:0046929)2.34030459
192photoreceptor cell maintenance (GO:0045494)2.32413428
193protein K63-linked deubiquitination (GO:0070536)2.32373727
194regulation of alpha-beta T cell proliferation (GO:0046640)2.32257191
195nerve growth factor signaling pathway (GO:0038180)2.32126143
196polyol transport (GO:0015791)2.32074073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61990149
2GBX2_23144817_ChIP-Seq_PC3_Human4.16116358
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21921853
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.92377793
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70298250
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66557070
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60913667
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.60485302
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50233741
10TAF15_26573619_Chip-Seq_HEK293_Human2.50179876
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28539132
12DROSHA_22980978_ChIP-Seq_HELA_Human2.27865349
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25273768
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25233800
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25233800
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23369570
17REST_21632747_ChIP-Seq_MESCs_Mouse2.18057362
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.17624842
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17185127
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15348578
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11055268
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.11013426
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09415901
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.07366438
25GATA1_22025678_ChIP-Seq_K562_Human2.06482816
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06458890
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02704208
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.00300098
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99564972
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96386928
31FUS_26573619_Chip-Seq_HEK293_Human1.92818762
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92756642
33SMAD4_21799915_ChIP-Seq_A2780_Human1.92204567
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91771269
35VDR_22108803_ChIP-Seq_LS180_Human1.91467477
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87297751
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.85848046
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.82618435
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79584721
40P300_19829295_ChIP-Seq_ESCs_Human1.78361419
41AR_21572438_ChIP-Seq_LNCaP_Human1.77868288
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77639103
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76469021
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69220893
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66329790
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64985766
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.62239301
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.58875989
49ZNF274_21170338_ChIP-Seq_K562_Hela1.56091225
50TP53_16413492_ChIP-PET_HCT116_Human1.55891965
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53699459
52STAT3_23295773_ChIP-Seq_U87_Human1.53528313
53* REST_18959480_ChIP-ChIP_MESCs_Mouse1.53249424
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.52228546
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49965898
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48935591
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47767011
58* SMAD_19615063_ChIP-ChIP_OVARY_Human1.46967399
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44862803
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43564327
61AR_25329375_ChIP-Seq_VCAP_Human1.43260563
62RUNX_20019798_ChIP-Seq_JUKART_Human1.43072033
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.42563812
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37094396
65TCF4_23295773_ChIP-Seq_U87_Human1.37007765
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36986922
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36926317
68CBP_20019798_ChIP-Seq_JUKART_Human1.35182703
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35182703
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34259792
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34068664
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.33812907
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33696290
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32498004
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.31814593
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28633975
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.28476674
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28058777
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27959363
80IGF1R_20145208_ChIP-Seq_DFB_Human1.26968332
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.26768918
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26709970
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.25708037
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24908264
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24437462
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.23413739
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22229721
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.21963385
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20639380
90IRF1_19129219_ChIP-ChIP_H3396_Human1.20077231
91* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20072086
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19720893
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19209513
94EWS_26573619_Chip-Seq_HEK293_Human1.18881556
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18177359
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17526936
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17526936
98AR_19668381_ChIP-Seq_PC3_Human1.16694489
99* TCF4_22108803_ChIP-Seq_LS180_Human1.16345579
100ER_23166858_ChIP-Seq_MCF-7_Human1.15923513
101* P300_18555785_Chip-Seq_ESCs_Mouse1.15384526
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15250320
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14990990
104ELK1_19687146_ChIP-ChIP_HELA_Human1.14825595
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14377804
106RUNX2_22187159_ChIP-Seq_PCA_Human1.14107264
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13519636
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.12432113
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12417050
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12264023
111MYB_26560356_Chip-Seq_TH2_Human1.11915816
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11598907
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10998311
114BCAT_22108803_ChIP-Seq_LS180_Human1.10918622
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10720387
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.10439266
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.10112649
118RNF2_27304074_Chip-Seq_NSC_Mouse1.10011321
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09962194
120GATA3_26560356_Chip-Seq_TH2_Human1.09781798
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09320723
122AHR_22903824_ChIP-Seq_MCF-7_Human1.08806171
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07995344
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07704733
125PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07455448
126* P53_22387025_ChIP-Seq_ESCs_Mouse1.06560875
127* OCT4_18555785_Chip-Seq_ESCs_Mouse1.06251055
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05428506
129* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05389869
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05035544
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04926311
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04926311
133RING1B_27294783_Chip-Seq_ESCs_Mouse1.04656552
134CMYC_18555785_Chip-Seq_ESCs_Mouse1.04326912
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.03813565
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03012702
137GATA3_27048872_Chip-Seq_THYMUS_Human1.02940363
138IRF8_27001747_Chip-Seq_BMDM_Mouse1.02881761
139WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01994392
140TP53_18474530_ChIP-ChIP_U2OS_Human1.01956049
141FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00884986
142* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99226074
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97597160
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96759298
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96734053
146JUN_21703547_ChIP-Seq_K562_Human0.95422632
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.93528189
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.93430252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99429298
2MP0003880_abnormal_central_pattern5.19074592
3MP0003635_abnormal_synaptic_transmissio3.95366404
4MP0008057_abnormal_DNA_replication3.55731960
5MP0009745_abnormal_behavioral_response3.45180128
6MP0004270_analgesia3.19136021
7MP0002064_seizures3.17442537
8MP0009046_muscle_twitch3.14483553
9MP0002063_abnormal_learning/memory/cond3.05424078
10MP0001968_abnormal_touch/_nociception3.01538047
11MP0001835_abnormal_antigen_presentation2.88408782
12MP0005423_abnormal_somatic_nervous2.84601797
13MP0002572_abnormal_emotion/affect_behav2.81220513
14MP0001486_abnormal_startle_reflex2.80612831
15MP0001501_abnormal_sleep_pattern2.76775009
16MP0002272_abnormal_nervous_system2.74736609
17MP0002735_abnormal_chemical_nociception2.54502989
18MP0002736_abnormal_nociception_after2.50351183
19MP0005075_abnormal_melanosome_morpholog2.50059918
20MP0000427_abnormal_hair_cycle2.35988985
21MP0002396_abnormal_hematopoietic_system2.28345082
22MP0003787_abnormal_imprinting2.26885601
23MP0003763_abnormal_thymus_physiology2.23998593
24MP0002067_abnormal_sensory_capabilities2.23628258
25MP0003724_increased_susceptibility_to2.17262171
26MP0001440_abnormal_grooming_behavior2.16625880
27MP0002734_abnormal_mechanical_nocicepti2.15325070
28MP0002166_altered_tumor_susceptibility2.11993622
29MP0001188_hyperpigmentation1.99750053
30MP0008569_lethality_at_weaning1.93722383
31MP0002822_catalepsy1.91660754
32MP0001800_abnormal_humoral_immune1.90745624
33MP0000569_abnormal_digit_pigmentation1.90653114
34MP0005551_abnormal_eye_electrophysiolog1.79718327
35MP0004924_abnormal_behavior1.75690413
36MP0005386_behavior/neurological_phenoty1.75690413
37MP0000778_abnormal_nervous_system1.75498963
38MP0005409_darkened_coat_color1.72506680
39MP0002733_abnormal_thermal_nociception1.69031080
40MP0001970_abnormal_pain_threshold1.68549952
41MP0001984_abnormal_olfaction1.68063053
42MP0002557_abnormal_social/conspecific_i1.65970683
43MP0005646_abnormal_pituitary_gland1.64829753
44MP0002184_abnormal_innervation1.62885062
45MP0002928_abnormal_bile_duct1.62189223
46MP0005671_abnormal_response_to1.59582326
47MP0001502_abnormal_circadian_rhythm1.57039299
48MP0004885_abnormal_endolymph1.54363252
49MP0000955_abnormal_spinal_cord1.49197568
50MP0009780_abnormal_chondrocyte_physiolo1.43371319
51MP0003879_abnormal_hair_cell1.42098404
52MP0002882_abnormal_neuron_morphology1.40851898
53MP0003329_amyloid_beta_deposits1.40819301
54MP0001986_abnormal_taste_sensitivity1.39524577
55MP0000685_abnormal_immune_system1.35436815
56MP0005645_abnormal_hypothalamus_physiol1.34525867
57MP0006276_abnormal_autonomic_nervous1.34503293
58MP0006072_abnormal_retinal_apoptosis1.33948752
59MP0002909_abnormal_adrenal_gland1.33058124
60MP0002723_abnormal_immune_serum1.32095132
61MP0008877_abnormal_DNA_methylation1.30696724
62MP0002006_tumorigenesis1.28767436
63MP0004147_increased_porphyrin_level1.28564746
64MP0004142_abnormal_muscle_tone1.28334270
65MP0002066_abnormal_motor_capabilities/c1.27536817
66MP0002420_abnormal_adaptive_immunity1.26218300
67MP0004811_abnormal_neuron_physiology1.25135883
68MP0002095_abnormal_skin_pigmentation1.24925755
69MP0003633_abnormal_nervous_system1.24574835
70MP0001819_abnormal_immune_cell1.23582611
71MP0004742_abnormal_vestibular_system1.23349026
72MP0003866_abnormal_defecation1.18281064
73MP0002398_abnormal_bone_marrow1.18243914
74MP0006292_abnormal_olfactory_placode1.18026283
75MP0002452_abnormal_antigen_presenting1.17986359
76MP0004145_abnormal_muscle_electrophysio1.16958180
77MP0004043_abnormal_pH_regulation1.14718856
78MP0000689_abnormal_spleen_morphology1.14659723
79MP0003221_abnormal_cardiomyocyte_apopto1.11073463
80MP0002229_neurodegeneration1.10895359
81MP0000372_irregular_coat_pigmentation1.10875975
82MP0004808_abnormal_hematopoietic_stem1.10577774
83MP0006054_spinal_hemorrhage1.09520462
84MP0005000_abnormal_immune_tolerance1.08182595
85MP0001529_abnormal_vocalization1.07107689
86MP0002405_respiratory_system_inflammati1.06333360
87MP0002152_abnormal_brain_morphology1.05950860
88MP0001485_abnormal_pinna_reflex1.05796045
89MP0000716_abnormal_immune_system1.05312803
90MP0004484_altered_response_of1.04131660
91MP0005248_abnormal_Harderian_gland1.03544830
92MP0003631_nervous_system_phenotype1.03192752
93MP0004883_abnormal_blood_vessel1.02272961
94MP0003252_abnormal_bile_duct1.00988496
95MP0005387_immune_system_phenotype1.00584874
96MP0001790_abnormal_immune_system1.00584874
97MP0010678_abnormal_skin_adnexa0.96560416
98MP0002102_abnormal_ear_morphology0.95498950
99MP0000383_abnormal_hair_follicle0.95399902
100MP0003690_abnormal_glial_cell0.95231950
101MP0000703_abnormal_thymus_morphology0.95166122
102MP0003300_gastrointestinal_ulcer0.94690208
103MP0001963_abnormal_hearing_physiology0.94514259
104MP0001905_abnormal_dopamine_level0.93743313
105MP0005253_abnormal_eye_physiology0.93734635
106MP0000631_abnormal_neuroendocrine_gland0.91807704
107MP0005367_renal/urinary_system_phenotyp0.91223475
108MP0000516_abnormal_urinary_system0.91223475
109MP0002419_abnormal_innate_immunity0.90463164
110MP0003172_abnormal_lysosome_physiology0.90329398
111MP0005389_reproductive_system_phenotype0.88308918
112MP0002752_abnormal_somatic_nervous0.87950550
113MP0000920_abnormal_myelination0.87873219
114MP0003183_abnormal_peptide_metabolism0.86291402
115MP0002722_abnormal_immune_system0.84884414
116MP0003303_peritoneal_inflammation0.84643840
117MP0003567_abnormal_fetal_cardiomyocyte0.84151592
118MP0003634_abnormal_glial_cell0.83762734
119MP0002638_abnormal_pupillary_reflex0.82664430
120MP0004215_abnormal_myocardial_fiber0.82099572
121MP0002751_abnormal_autonomic_nervous0.81914835
122MP0002069_abnormal_eating/drinking_beha0.81479503
123MP0003943_abnormal_hepatobiliary_system0.81417860
124MP0003632_abnormal_nervous_system0.80700898
125MP0002234_abnormal_pharynx_morphology0.80528007
126MP0005397_hematopoietic_system_phenotyp0.80433098
127MP0001545_abnormal_hematopoietic_system0.80433098
128MP0002009_preneoplasia0.79918885
129MP0003045_fibrosis0.79780241
130MP0005174_abnormal_tail_pigmentation0.77701604
131MP0010386_abnormal_urinary_bladder0.77690705
132MP0000465_gastrointestinal_hemorrhage0.76564299
133MP0002090_abnormal_vision0.76231034
134MP0008789_abnormal_olfactory_epithelium0.76001626
135MP0004858_abnormal_nervous_system0.75266192
136MP0003656_abnormal_erythrocyte_physiolo0.75031736
137MP0003136_yellow_coat_color0.74807549
138MP0005310_abnormal_salivary_gland0.74525710
139MP0003890_abnormal_embryonic-extraembry0.73871610
140MP0008874_decreased_physiological_sensi0.73871303
141MP0004085_abnormal_heartbeat0.73386839
142MP0003121_genomic_imprinting0.71175014
143MP0008058_abnormal_DNA_repair0.70176427
144MP0000013_abnormal_adipose_tissue0.69001097
145MP0008872_abnormal_physiological_respon0.68866672
146MP0003195_calcinosis0.68468207
147MP0001177_atelectasis0.67163044
148MP0003122_maternal_imprinting0.64889153
149MP0005394_taste/olfaction_phenotype0.61276174
150MP0005499_abnormal_olfactory_system0.61276174
151MP0000026_abnormal_inner_ear0.60948190
152MP0005195_abnormal_posterior_eye0.60710917
153MP0000015_abnormal_ear_pigmentation0.60689356
154MP0005171_absent_coat_pigmentation0.59526398
155MP0004510_myositis0.58213942
156MP0010770_preweaning_lethality0.57471183
157MP0002082_postnatal_lethality0.57471183
158MP0010769_abnormal_survival0.56644212
159MP0003861_abnormal_nervous_system0.54695113
160MP0001299_abnormal_eye_distance/0.54449234
161MP0005535_abnormal_body_temperature0.54295058
162MP0010768_mortality/aging0.53905399
163MP0001943_abnormal_respiration0.53502302

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.57782700
2Focal seizures (HP:0007359)5.37474889
3Epileptic encephalopathy (HP:0200134)5.30027820
4Febrile seizures (HP:0002373)5.23045278
5Atonic seizures (HP:0010819)4.52040483
6Broad-based gait (HP:0002136)4.11595399
7Visual hallucinations (HP:0002367)4.07364190
8Absence seizures (HP:0002121)3.95870270
9Progressive cerebellar ataxia (HP:0002073)3.80343095
10Gaze-evoked nystagmus (HP:0000640)3.76131857
11Dialeptic seizures (HP:0011146)3.74318787
12Myokymia (HP:0002411)3.72274524
13Hyperventilation (HP:0002883)3.64424531
14Thyroiditis (HP:0100646)3.44026158
15Excessive salivation (HP:0003781)3.40460774
16Drooling (HP:0002307)3.40460774
17Generalized tonic-clonic seizures (HP:0002069)3.36466810
18Protruding tongue (HP:0010808)3.22691024
19Dysdiadochokinesis (HP:0002075)3.22000300
20Action tremor (HP:0002345)3.10404647
21Hemiparesis (HP:0001269)3.07961184
22Truncal ataxia (HP:0002078)3.06858931
23Dysmetria (HP:0001310)3.05666800
24Absent speech (HP:0001344)3.05516673
25Supranuclear gaze palsy (HP:0000605)3.03447363
26Poor eye contact (HP:0000817)3.03233651
27Diplopia (HP:0000651)3.02758222
28Abnormality of binocular vision (HP:0011514)3.02758222
29Abnormality of the renal medulla (HP:0100957)2.88860297
30Scanning speech (HP:0002168)2.88721157
31Abnormality of the renal cortex (HP:0011035)2.88432829
32Tubulointerstitial nephritis (HP:0001970)2.83957432
33Molar tooth sign on MRI (HP:0002419)2.83337196
34Abnormality of midbrain morphology (HP:0002418)2.83337196
35Papilledema (HP:0001085)2.81006528
36Pancreatic cysts (HP:0001737)2.80862286
37Panhypogammaglobulinemia (HP:0003139)2.77702430
38Pancreatic fibrosis (HP:0100732)2.77436487
39Medial flaring of the eyebrow (HP:0010747)2.77138436
40Abnormal ciliary motility (HP:0012262)2.76878347
41Abnormal social behavior (HP:0012433)2.76426883
42Impaired social interactions (HP:0000735)2.76426883
43Widely spaced teeth (HP:0000687)2.73455015
44Renal cortical cysts (HP:0000803)2.73364808
45Inappropriate behavior (HP:0000719)2.72362152
46T lymphocytopenia (HP:0005403)2.70915463
47Impaired smooth pursuit (HP:0007772)2.70211909
48Genetic anticipation (HP:0003743)2.67800641
49Hemiplegia (HP:0002301)2.66523275
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.65205004
51Chronic mucocutaneous candidiasis (HP:0002728)2.59932655
52Recurrent cutaneous fungal infections (HP:0011370)2.59932655
53Abnormality of ocular smooth pursuit (HP:0000617)2.58318200
54Postural instability (HP:0002172)2.57722542
55Progressive inability to walk (HP:0002505)2.54071155
56Abnormality of T cell number (HP:0011839)2.52321926
57Severe combined immunodeficiency (HP:0004430)2.50051052
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49124523
59Depression (HP:0000716)2.45914504
60Abnormal respiratory motile cilium physiology (HP:0012261)2.45756726
61Absent/shortened dynein arms (HP:0200106)2.45490054
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.45490054
63Congenital stationary night blindness (HP:0007642)2.45149180
64Clumsiness (HP:0002312)2.40951698
65Fair hair (HP:0002286)2.39157463
66Type II lissencephaly (HP:0007260)2.39021697
67True hermaphroditism (HP:0010459)2.36978052
68Amblyopia (HP:0000646)2.34558743
69Stereotypic behavior (HP:0000733)2.33405688
70Congenital primary aphakia (HP:0007707)2.31938286
71Abnormality of salivation (HP:0100755)2.31700212
72Stomach cancer (HP:0012126)2.31437085
73Neurofibrillary tangles (HP:0002185)2.29877881
74Chronic hepatic failure (HP:0100626)2.28846113
75Cerebral inclusion bodies (HP:0100314)2.27550209
76Papillary thyroid carcinoma (HP:0002895)2.26813717
77Nephrogenic diabetes insipidus (HP:0009806)2.26662630
78Acute lymphatic leukemia (HP:0006721)2.26468950
79Urinary bladder sphincter dysfunction (HP:0002839)2.26428381
80Generalized hypopigmentation of hair (HP:0011358)2.26401129
81Impaired vibration sensation in the lower limbs (HP:0002166)2.25632254
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.24174042
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24174042
84Acute myeloid leukemia (HP:0004808)2.22911111
85Intention tremor (HP:0002080)2.22814792
86Epileptiform EEG discharges (HP:0011182)2.22752698
87Amyotrophic lateral sclerosis (HP:0007354)2.21588393
88Blue irides (HP:0000635)2.18468957
89Exotropia (HP:0000577)2.13967916
90Hypothermia (HP:0002045)2.11143911
91Chronic sinusitis (HP:0011109)2.10420594
92Anxiety (HP:0000739)2.10089619
93Bradykinesia (HP:0002067)2.09186336
94Status epilepticus (HP:0002133)2.09001917
95Hematochezia (HP:0002573)2.08906009
96Attenuation of retinal blood vessels (HP:0007843)2.08621867
97Recurrent fungal infections (HP:0002841)2.08414250
98Hip dysplasia (HP:0001385)2.06379858
99EEG with generalized epileptiform discharges (HP:0011198)2.02611384
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00425435
101Deeply set eye (HP:0000490)2.00278433
102Oligodactyly (hands) (HP:0001180)1.99237580
103Thickened helices (HP:0000391)1.97448397
104Spastic gait (HP:0002064)1.97136876
105Macroorchidism (HP:0000053)1.97017579
106Abnormal rod and cone electroretinograms (HP:0008323)1.96532845
107Retinal dysplasia (HP:0007973)1.95197755
108Congenital hepatic fibrosis (HP:0002612)1.93813572
109Constricted visual fields (HP:0001133)1.93489350
110Postaxial foot polydactyly (HP:0001830)1.92026736
111Recurrent sinusitis (HP:0011108)1.91927341
112Stomatitis (HP:0010280)1.91530100
113Inability to walk (HP:0002540)1.91391492
114IgM deficiency (HP:0002850)1.90294755
115Abolished electroretinogram (ERG) (HP:0000550)1.88503352
116Abnormality of the prostate (HP:0008775)1.88057848
117Cystic liver disease (HP:0006706)1.87856226
118Gastroesophageal reflux (HP:0002020)1.87286954
119Recurrent bronchitis (HP:0002837)1.87276590
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.86956056
121Gonadotropin excess (HP:0000837)1.86062426
122Hypoplasia of the thymus (HP:0000778)1.85944159
123Neoplasm of the tracheobronchial system (HP:0100552)1.85817606
124Poor coordination (HP:0002370)1.85604005
125Abnormality of eosinophils (HP:0001879)1.85445040
126Abnormality of macular pigmentation (HP:0008002)1.85241744
127Genital tract atresia (HP:0001827)1.85068930
128Dysmetric saccades (HP:0000641)1.84404274
129Impaired vibratory sensation (HP:0002495)1.84176717
130Neoplasm of the adrenal cortex (HP:0100641)1.84130880
131Truncal obesity (HP:0001956)1.84082972
132Abnormality of the corticospinal tract (HP:0002492)1.83641149
133Metaphyseal dysplasia (HP:0100255)1.83176699
134Thyroid carcinoma (HP:0002890)1.83108447
135Decreased central vision (HP:0007663)1.81022849
136Hypoplastic iliac wings (HP:0002866)1.80245989
137Bronchiectasis (HP:0002110)1.80131746
138Supernumerary spleens (HP:0009799)1.79840258
139Tented upper lip vermilion (HP:0010804)1.79833877
140Short foot (HP:0001773)1.79765090
141Volvulus (HP:0002580)1.79601339
142Central scotoma (HP:0000603)1.79025782
143Recurrent bacterial skin infections (HP:0005406)1.78959209
144Gait ataxia (HP:0002066)1.78829584
145Hypsarrhythmia (HP:0002521)1.77877012
146Cutis marmorata (HP:0000965)1.77827239
147Tubulointerstitial abnormality (HP:0001969)1.77487703
148Abnormal biliary tract physiology (HP:0012439)1.77353041
149Bile duct proliferation (HP:0001408)1.77353041
150Obsessive-compulsive behavior (HP:0000722)1.75195631
151Aqueductal stenosis (HP:0002410)1.75133961
152Macroglossia (HP:0000158)1.74625277
153Decreased circulating renin level (HP:0003351)1.73796633
154Nephronophthisis (HP:0000090)1.73103233
155Agammaglobulinemia (HP:0004432)1.72715424
156Psychosis (HP:0000709)1.72047484
157Autism (HP:0000717)1.71517048
158Postaxial hand polydactyly (HP:0001162)1.71105762
159Ankyloglossia (HP:0010296)1.71057073
160Confusion (HP:0001289)1.70203843
161Abnormality of T cells (HP:0002843)1.70134047
162Abnormal respiratory epithelium morphology (HP:0012253)1.69592262
163Abnormal respiratory motile cilium morphology (HP:0005938)1.69592262
164Vaginal atresia (HP:0000148)1.69220711
165Neuronal loss in central nervous system (HP:0002529)1.69028882
166Urinary urgency (HP:0000012)1.67480391
167Alveolar cell carcinoma (HP:0006519)1.67168971
168Recurrent skin infections (HP:0001581)1.67043644
169Termporal pattern (HP:0011008)1.66761522
170Insidious onset (HP:0003587)1.66761522
171Colitis (HP:0002583)1.65816724
172Gait imbalance (HP:0002141)1.65746112
173Hypoventilation (HP:0002791)1.65438292
174Abnormality of oral frenula (HP:0000190)1.64763371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.92828298
2EPHA44.66983380
3TNIK4.19821585
4MAP3K42.91043157
5RIPK42.85086397
6MAP2K72.60814107
7TAOK32.29789280
8SIK22.28438959
9PNCK2.24876083
10CASK2.20454786
11ACVR1B2.20260845
12MAP3K92.12880599
13NTRK22.00212398
14MAP3K131.97503805
15TEC1.95006264
16ERBB31.93519735
17KIT1.92825143
18FES1.83622446
19BMPR1B1.78174030
20CAMKK21.75187685
21DAPK21.73819547
22MAPK131.71216225
23WNK31.71034840
24MAP2K41.67055800
25TRPM71.64888298
26MINK11.62838853
27PINK11.56200150
28MARK11.53087996
29CAMK1G1.50955323
30BLK1.45474172
31PAK61.39713867
32PRPF4B1.37145907
33MAP3K141.31231242
34TXK1.30976949
35BCR1.29755974
36PLK21.29308198
37CDK51.28953290
38NLK1.27489404
39NUAK11.22081542
40SYK1.19917827
41FGFR31.19627630
42DAPK11.17272490
43CAMKK11.17222806
44FLT31.15577840
45BTK1.14711662
46STK161.14081699
47KSR11.11010401
48CAMK11.10884213
49EPHA31.08260202
50CAMK2B1.08039926
51TYK21.06626945
52DYRK1A1.05179198
53NTRK11.04923854
54MKNK11.04864823
55CAMK2A1.04842477
56MAP4K11.04214037
57MAP3K121.02919269
58TNK21.00086461
59JAK10.99564040
60PRKCG0.97859668
61ITK0.96703458
62SGK10.96000160
63MARK20.95396625
64STK380.94813050
65FGFR20.94662350
66BMPR20.94511442
67IKBKE0.92207690
68CDK190.91484279
69WNK10.91096899
70BRD40.89936683
71MAP3K70.88821156
72CSF1R0.86255859
73JAK30.85759094
74KSR20.85459604
75PRKD30.85269606
76SGK20.85075867
77CDK30.84761548
78LYN0.84236106
79OXSR10.84109686
80LCK0.83820490
81MAP4K20.82071513
82MAP3K60.81494448
83PIK3CG0.80966453
84GRK60.80155575
85YES10.79459377
86NEK60.79411001
87FGR0.78701700
88HCK0.77318356
89GRK50.76865865
90CAMK1D0.75779122
91PRKD20.72974869
92STK110.72846994
93MUSK0.72614891
94MAP3K20.72159098
95JAK20.71203522
96PTK2B0.71010885
97SGK2230.70713294
98SGK4940.70713294
99CAMK2D0.70639545
100IRAK10.69829851
101CSNK1G20.69732027
102MKNK20.68829196
103STK38L0.66345849
104UHMK10.66249411
105PRKCH0.66174615
106MARK30.66141418
107TRIM280.65487045
108CSK0.64675732
109SGK30.64426751
110PRKCE0.63917810
111MATK0.62855803
112RAF10.62694488
113BRSK20.62257745
114CDC42BPA0.60318083
115TYRO30.60181986
116RET0.58491560
117IRAK40.55912256
118FYN0.55248109
119MAPK100.54596846
120CDK60.53250701
121ABL10.53166582
122TAOK20.52644447
123RPS6KA30.52514602
124PDK10.52404085
125PRKG10.50952797
126SIK30.50124838
127CSNK1A1L0.49164048
128PRKCQ0.48623133
129PASK0.48396312
130PKN10.47934400
131PAK30.47648506
132EGFR0.47196294
133PRKCB0.46437816
134ZAP700.44667509
135PDPK10.44043340
136CDK150.43981630
137CDK180.42878795
138GRK10.40997865
139MAPK70.40853662
140TGFBR10.40599714
141CAMK40.39655672
142RPS6KA40.38788149
143FRK0.38546097
144MAPK120.38490141
145STK390.37924009
146CAMK2G0.37677071
147CDK11A0.37148297
148CSNK1G10.37143164
149FER0.36490801
150GSK3B0.36229339
151ATM0.35860975
152PIK3CA0.35637281
153AKT30.35122229
154HIPK20.35035413
155CDK140.34935439
156PRKCA0.33575944
157INSRR0.33498640

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.44444985
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03232077
3Asthma_Homo sapiens_hsa053103.01684769
4Glutamatergic synapse_Homo sapiens_hsa047242.98189773
5Long-term potentiation_Homo sapiens_hsa047202.85342122
6Allograft rejection_Homo sapiens_hsa053302.77639413
7Circadian entrainment_Homo sapiens_hsa047132.76589899
8GABAergic synapse_Homo sapiens_hsa047272.76155752
9Morphine addiction_Homo sapiens_hsa050322.66257306
10Amphetamine addiction_Homo sapiens_hsa050312.55358953
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.55072773
12Autoimmune thyroid disease_Homo sapiens_hsa053202.42901497
13Graft-versus-host disease_Homo sapiens_hsa053322.39501997
14Synaptic vesicle cycle_Homo sapiens_hsa047212.34706874
15Olfactory transduction_Homo sapiens_hsa047402.31103686
16Salivary secretion_Homo sapiens_hsa049702.18490592
17Taste transduction_Homo sapiens_hsa047422.15484229
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11066991
19Dopaminergic synapse_Homo sapiens_hsa047282.10976532
20Insulin secretion_Homo sapiens_hsa049111.95368263
21Long-term depression_Homo sapiens_hsa047301.92126414
22Leishmaniasis_Homo sapiens_hsa051401.83826391
23Renin secretion_Homo sapiens_hsa049241.83737485
24Serotonergic synapse_Homo sapiens_hsa047261.81136691
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81124679
26Calcium signaling pathway_Homo sapiens_hsa040201.80396104
27Gastric acid secretion_Homo sapiens_hsa049711.72617823
28Primary immunodeficiency_Homo sapiens_hsa053401.72072835
29Cholinergic synapse_Homo sapiens_hsa047251.69537673
30Cocaine addiction_Homo sapiens_hsa050301.69119732
31Oxytocin signaling pathway_Homo sapiens_hsa049211.64480347
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58131208
33Phototransduction_Homo sapiens_hsa047441.56383611
34Staphylococcus aureus infection_Homo sapiens_hsa051501.52747528
35cAMP signaling pathway_Homo sapiens_hsa040241.41978220
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41142710
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40256952
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39837996
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39054172
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35246580
41Regulation of autophagy_Homo sapiens_hsa041401.32709322
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31412674
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.30047189
44GnRH signaling pathway_Homo sapiens_hsa049121.29684430
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23562704
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21696282
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16085289
48Tuberculosis_Homo sapiens_hsa051521.15753734
49Basal transcription factors_Homo sapiens_hsa030221.14685763
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14386969
51Non-homologous end-joining_Homo sapiens_hsa034501.14172553
52Antigen processing and presentation_Homo sapiens_hsa046121.12215723
53Axon guidance_Homo sapiens_hsa043601.11846940
54ABC transporters_Homo sapiens_hsa020101.11778699
55Circadian rhythm_Homo sapiens_hsa047101.09671688
56Fanconi anemia pathway_Homo sapiens_hsa034601.09568962
57Toxoplasmosis_Homo sapiens_hsa051451.09221250
58Type II diabetes mellitus_Homo sapiens_hsa049301.08749030
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08310467
60Pancreatic secretion_Homo sapiens_hsa049721.07063387
61Viral myocarditis_Homo sapiens_hsa054161.06710399
62Measles_Homo sapiens_hsa051621.06202938
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01647197
64Prolactin signaling pathway_Homo sapiens_hsa049171.01459968
65Collecting duct acid secretion_Homo sapiens_hsa049660.98912772
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96475186
67Herpes simplex infection_Homo sapiens_hsa051680.95691371
68Gap junction_Homo sapiens_hsa045400.95224558
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.95103093
70ErbB signaling pathway_Homo sapiens_hsa040120.94762642
71Ether lipid metabolism_Homo sapiens_hsa005650.94564127
72Hematopoietic cell lineage_Homo sapiens_hsa046400.94073628
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92679527
74RNA degradation_Homo sapiens_hsa030180.92517829
75Estrogen signaling pathway_Homo sapiens_hsa049150.92354558
76Osteoclast differentiation_Homo sapiens_hsa043800.91733804
77Choline metabolism in cancer_Homo sapiens_hsa052310.90070091
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88891580
79Influenza A_Homo sapiens_hsa051640.88823431
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.88110799
81Dorso-ventral axis formation_Homo sapiens_hsa043200.87830625
82Melanogenesis_Homo sapiens_hsa049160.87451577
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86678409
84Propanoate metabolism_Homo sapiens_hsa006400.85769509
85Thyroid hormone synthesis_Homo sapiens_hsa049180.85125529
86Linoleic acid metabolism_Homo sapiens_hsa005910.83802542
87FoxO signaling pathway_Homo sapiens_hsa040680.82745761
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82658077
89Protein export_Homo sapiens_hsa030600.82083853
90Butanoate metabolism_Homo sapiens_hsa006500.81623822
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79253652
92MAPK signaling pathway_Homo sapiens_hsa040100.78670206
93Inositol phosphate metabolism_Homo sapiens_hsa005620.76979028
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76543377
95Glioma_Homo sapiens_hsa052140.76150182
96Colorectal cancer_Homo sapiens_hsa052100.74088016
97Rheumatoid arthritis_Homo sapiens_hsa053230.68122623
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68054713
99Vibrio cholerae infection_Homo sapiens_hsa051100.66850754
100Oocyte meiosis_Homo sapiens_hsa041140.66797595
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66243494
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65380429
103Dilated cardiomyopathy_Homo sapiens_hsa054140.64398243
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.64103690
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59518599
106Hepatitis B_Homo sapiens_hsa051610.59236812
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59165875
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57024838
109Ras signaling pathway_Homo sapiens_hsa040140.56228049
110Legionellosis_Homo sapiens_hsa051340.56000152
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55872379
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55040690
113African trypanosomiasis_Homo sapiens_hsa051430.55017073
114Glucagon signaling pathway_Homo sapiens_hsa049220.54770375
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54350195
116Alcoholism_Homo sapiens_hsa050340.54165797
117Acute myeloid leukemia_Homo sapiens_hsa052210.52929187
118Wnt signaling pathway_Homo sapiens_hsa043100.52901223
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52841233
120Cardiac muscle contraction_Homo sapiens_hsa042600.52743375
121Pancreatic cancer_Homo sapiens_hsa052120.50900623
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50391435
123Rap1 signaling pathway_Homo sapiens_hsa040150.49568643
124Homologous recombination_Homo sapiens_hsa034400.47330439
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.46676649
126mTOR signaling pathway_Homo sapiens_hsa041500.45024852
127T cell receptor signaling pathway_Homo sapiens_hsa046600.44358819
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44321105
129VEGF signaling pathway_Homo sapiens_hsa043700.44216503
130Arachidonic acid metabolism_Homo sapiens_hsa005900.42223428
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40064301
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.39931161
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39807680
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39591386
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.37487727
136Chemokine signaling pathway_Homo sapiens_hsa040620.37308120
137B cell receptor signaling pathway_Homo sapiens_hsa046620.37303517
138Type I diabetes mellitus_Homo sapiens_hsa049400.36160574
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34226144
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33991943
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33226854
142Mineral absorption_Homo sapiens_hsa049780.33157405
143Ovarian steroidogenesis_Homo sapiens_hsa049130.30788366
144Platelet activation_Homo sapiens_hsa046110.29905273
145Non-small cell lung cancer_Homo sapiens_hsa052230.28962660
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26788407
147Fatty acid biosynthesis_Homo sapiens_hsa000610.25082810
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23617525
149Renal cell carcinoma_Homo sapiens_hsa052110.22392377
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21653706

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