TTC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.20997487
2acrosome reaction (GO:0007340)9.12742035
3acrosome assembly (GO:0001675)9.06283684
4multicellular organism reproduction (GO:0032504)8.62541812
5binding of sperm to zona pellucida (GO:0007339)8.58932344
6regulation of cilium movement (GO:0003352)8.42812979
7spermatid development (GO:0007286)8.38681939
8cell wall macromolecule catabolic process (GO:0016998)8.30243394
9cell wall macromolecule metabolic process (GO:0044036)8.30243394
10cell-cell recognition (GO:0009988)8.18376153
11axoneme assembly (GO:0035082)8.05280787
12piRNA metabolic process (GO:0034587)7.84276642
13plasma membrane fusion (GO:0045026)7.75119500
14ventricular system development (GO:0021591)7.59333075
15reproduction (GO:0000003)7.20070021
16male meiosis (GO:0007140)6.96440366
17negative regulation of inclusion body assembly (GO:0090084)6.76246624
18synaptonemal complex organization (GO:0070193)6.70801570
19GTP biosynthetic process (GO:0006183)6.41413305
20single fertilization (GO:0007338)6.35226825
21synaptonemal complex assembly (GO:0007130)6.05768018
22nucleoside diphosphate phosphorylation (GO:0006165)5.94540641
23sperm capacitation (GO:0048240)5.82678783
24UTP biosynthetic process (GO:0006228)5.76150189
25spermatogenesis (GO:0007283)5.67474291
26male meiosis I (GO:0007141)5.66013786
27male gamete generation (GO:0048232)5.65337486
28fertilization (GO:0009566)5.55749815
29regulation of inclusion body assembly (GO:0090083)5.54871248
30intraciliary transport (GO:0042073)5.26316930
31gamete generation (GO:0007276)5.20191391
32UTP metabolic process (GO:0046051)5.19961152
33left/right axis specification (GO:0070986)5.15904512
34DNA methylation involved in gamete generation (GO:0043046)4.96943183
35microtubule depolymerization (GO:0007019)4.93441169
36regulation of microtubule-based movement (GO:0060632)4.84663800
37microtubule severing (GO:0051013)4.83474381
38organic cation transport (GO:0015695)4.81609430
39cilium organization (GO:0044782)4.72243228
40germ cell development (GO:0007281)4.63514889
41meiosis I (GO:0007127)4.62462042
42guanosine-containing compound biosynthetic process (GO:1901070)4.60511570
43left/right pattern formation (GO:0060972)4.50260495
44cellular process involved in reproduction in multicellular organism (GO:0022412)4.45993362
45cilium assembly (GO:0042384)4.43944763
46CTP biosynthetic process (GO:0006241)4.30334591
47CTP metabolic process (GO:0046036)4.30334591
48meiotic cell cycle (GO:0051321)4.28864662
49chromosome organization involved in meiosis (GO:0070192)4.25608241
50meiotic nuclear division (GO:0007126)4.24043851
51microtubule-based movement (GO:0007018)4.19036176
52centriole assembly (GO:0098534)4.17966892
53cilium morphogenesis (GO:0060271)4.12296571
54response to pheromone (GO:0019236)4.11293530
55multicellular organismal reproductive process (GO:0048609)4.07555546
56DNA deamination (GO:0045006)4.03034316
57spermatid nucleus differentiation (GO:0007289)3.99828155
58cellular component assembly involved in morphogenesis (GO:0010927)3.97349358
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.96546887
60L-fucose catabolic process (GO:0042355)3.93681194
61fucose catabolic process (GO:0019317)3.93681194
62L-fucose metabolic process (GO:0042354)3.93681194
63protein localization to cilium (GO:0061512)3.93501188
64calcium ion-dependent exocytosis (GO:0017156)3.93480800
65microtubule bundle formation (GO:0001578)3.89583522
66protein refolding (GO:0042026)3.84710036
67cell recognition (GO:0008037)3.83560864
68behavioral response to nicotine (GO:0035095)3.76166515
69centriole replication (GO:0007099)3.73867047
70seminiferous tubule development (GO:0072520)3.72002961
71pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.65630316
72tolerance induction (GO:0002507)3.64734169
73pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.62933676
74protein polyglutamylation (GO:0018095)3.54270292
75genitalia morphogenesis (GO:0035112)3.45672448
76nucleotide phosphorylation (GO:0046939)3.28635860
77negative regulation of telomere maintenance (GO:0032205)3.27885154
78detection of light stimulus involved in visual perception (GO:0050908)3.26835047
79detection of light stimulus involved in sensory perception (GO:0050962)3.26835047
80activated T cell proliferation (GO:0050798)3.26566446
81neural tube formation (GO:0001841)3.26294594
82negative regulation of T cell differentiation in thymus (GO:0033085)3.25664487
83DNA packaging (GO:0006323)3.23221708
84nucleoside diphosphate metabolic process (GO:0009132)3.20880058
85pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.19526822
86cytidine metabolic process (GO:0046087)3.18851548
87cytidine catabolic process (GO:0006216)3.18851548
88cytidine deamination (GO:0009972)3.18851548
89chromosome condensation (GO:0030261)3.17918061
90multicellular organismal development (GO:0007275)3.14642288
91glycerol ether metabolic process (GO:0006662)3.13793031
92exogenous drug catabolic process (GO:0042738)3.09919438
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01649509
94sequestering of actin monomers (GO:0042989)3.01350765
95chaperone-mediated protein complex assembly (GO:0051131)3.01111283
96rRNA catabolic process (GO:0016075)3.00820819
97cell projection assembly (GO:0030031)2.96818493
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.96801161
99regulation of memory T cell differentiation (GO:0043380)2.91736578
100pyrimidine ribonucleoside catabolic process (GO:0046133)2.89514830
101ether metabolic process (GO:0018904)2.88876146
102nonmotile primary cilium assembly (GO:0035058)2.87843618
103cellular ketone body metabolic process (GO:0046950)2.87518676
104positive regulation of defense response to virus by host (GO:0002230)2.86871814
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84619214
106regulation of germinal center formation (GO:0002634)2.80296271
107response to xenobiotic stimulus (GO:0009410)2.80130134
108meiotic cell cycle process (GO:1903046)2.77320803
109cellular response to interleukin-15 (GO:0071350)2.75810594
110negative regulation of immunoglobulin mediated immune response (GO:0002890)2.75661914
111negative regulation of B cell mediated immunity (GO:0002713)2.75661914
112one-carbon compound transport (GO:0019755)2.74934459
113single strand break repair (GO:0000012)2.72625162
114regulation of spindle checkpoint (GO:0090231)2.72150088
115retinal cone cell development (GO:0046549)2.71127560
116drug catabolic process (GO:0042737)2.70306198
117gene silencing by RNA (GO:0031047)2.66210469
118ketone body metabolic process (GO:1902224)2.62605208
119synapsis (GO:0007129)2.60577039
120positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60576542
121nucleus organization (GO:0006997)2.58951282
122photoreceptor cell maintenance (GO:0045494)2.58609567
123monoubiquitinated protein deubiquitination (GO:0035520)2.57833693
124positive regulation of tolerance induction (GO:0002645)2.57678390
125adaptation of signaling pathway (GO:0023058)2.57291317
126regulation of centriole replication (GO:0046599)2.56196979
127organelle assembly (GO:0070925)2.54647452
128determination of left/right symmetry (GO:0007368)2.52907324
129regulation of T cell mediated cytotoxicity (GO:0001914)2.52070155
130negative T cell selection (GO:0043383)2.51440222
131hydrogen peroxide biosynthetic process (GO:0050665)2.51209060
132protein-cofactor linkage (GO:0018065)2.49147740
133preassembly of GPI anchor in ER membrane (GO:0016254)2.48909388
134lactate metabolic process (GO:0006089)2.48896783
135superoxide anion generation (GO:0042554)2.48064069
136negative regulation of adaptive immune response (GO:0002820)2.47318214
137vitamin transmembrane transport (GO:0035461)2.46686502
138smoothened signaling pathway (GO:0007224)2.46363574
139spinal cord motor neuron differentiation (GO:0021522)2.45403519
140negative regulation of mast cell activation (GO:0033004)2.45143513
141indolalkylamine metabolic process (GO:0006586)2.42577501
142microtubule-based process (GO:0007017)2.41826366
143tryptophan catabolic process (GO:0006569)2.41567410
144indole-containing compound catabolic process (GO:0042436)2.41567410
145indolalkylamine catabolic process (GO:0046218)2.41567410
146pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.41129752
147phosphatidylethanolamine metabolic process (GO:0046337)2.39530887
148neuronal action potential (GO:0019228)2.39202962
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.36352665
150sulfation (GO:0051923)2.36335872
151phosphatidylethanolamine biosynthetic process (GO:0006646)2.36162196
152G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.35043638
153cornea development in camera-type eye (GO:0061303)2.32748826
154regulation of interleukin-5 production (GO:0032674)2.32079611
155platelet dense granule organization (GO:0060155)2.31256961
156negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.31053778
157regulation of collateral sprouting (GO:0048670)2.29498137
158negative regulation of lymphocyte mediated immunity (GO:0002707)2.28993238
159positive regulation of calcium-mediated signaling (GO:0050850)2.28488031
160positive regulation of oligodendrocyte differentiation (GO:0048714)2.27213890
161regulation of gamma-delta T cell differentiation (GO:0045586)2.26377768
162cilium or flagellum-dependent cell motility (GO:0001539)14.9045338
163axonemal dynein complex assembly (GO:0070286)14.7210654
164cilium movement (GO:0003341)13.2552570
165epithelial cilium movement (GO:0003351)12.2346348
166sperm motility (GO:0030317)11.2059038
167motile cilium assembly (GO:0044458)11.0136629
168fusion of sperm to egg plasma membrane (GO:0007342)10.3320717
169epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.2162930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.55437832
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.17085991
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.10113578
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02153666
5EZH2_22144423_ChIP-Seq_EOC_Human3.90010700
6GATA1_26923725_Chip-Seq_HPCs_Mouse2.64894939
7GBX2_23144817_ChIP-Seq_PC3_Human2.32022305
8EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.26783114
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.25133421
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20232123
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11436164
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97842950
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95701433
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91827516
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.90946191
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.89434476
17ER_23166858_ChIP-Seq_MCF-7_Human1.87693672
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85018606
19VDR_22108803_ChIP-Seq_LS180_Human1.84528650
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84169468
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.83037746
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80216149
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79282913
24TAF15_26573619_Chip-Seq_HEK293_Human1.79132734
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.78102747
26IGF1R_20145208_ChIP-Seq_DFB_Human1.75899190
27SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.72810681
28STAT1_17558387_ChIP-Seq_HELA_Human1.69732191
29BCAT_22108803_ChIP-Seq_LS180_Human1.66588329
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64863158
31EWS_26573619_Chip-Seq_HEK293_Human1.64148783
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.62740282
33P300_19829295_ChIP-Seq_ESCs_Human1.61728012
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58578926
35SOX2_22085726_ChIP-Seq_NPCs_Mouse1.57944349
36FUS_26573619_Chip-Seq_HEK293_Human1.56488067
37* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50362843
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.50169205
39ZNF274_21170338_ChIP-Seq_K562_Hela1.50062334
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48988030
41GATA3_21867929_ChIP-Seq_CD8_Mouse1.48742090
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47452183
43TP53_22573176_ChIP-Seq_HFKS_Human1.47097303
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.46634814
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.45121260
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44347416
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.43512133
48DROSHA_22980978_ChIP-Seq_HELA_Human1.41609291
49GATA3_26560356_Chip-Seq_TH2_Human1.41145390
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40124904
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38244866
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38200183
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.36985916
54STAT3_23295773_ChIP-Seq_U87_Human1.36552406
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36251196
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35552531
57RNF2_27304074_Chip-Seq_NSC_Mouse1.34312253
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33900001
59CBP_20019798_ChIP-Seq_JUKART_Human1.33900001
60AR_20517297_ChIP-Seq_VCAP_Human1.33234080
61SOX2_19829295_ChIP-Seq_ESCs_Human1.32969360
62NANOG_19829295_ChIP-Seq_ESCs_Human1.32969360
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32506977
64RUNX_20019798_ChIP-Seq_JUKART_Human1.32404799
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31942239
66AR_25329375_ChIP-Seq_VCAP_Human1.31191109
67FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29917290
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.29815861
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29580984
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29473223
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29473223
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28627339
73NCOR_22424771_ChIP-Seq_293T_Human1.27788678
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27716052
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27516057
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.27326320
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27247007
78TCF4_23295773_ChIP-Seq_U87_Human1.26825442
79TCF4_22108803_ChIP-Seq_LS180_Human1.25268343
80P53_21459846_ChIP-Seq_SAOS-2_Human1.25181407
81ERG_20517297_ChIP-Seq_VCAP_Human1.23082571
82IRF1_19129219_ChIP-ChIP_H3396_Human1.23043459
83GF1_26923725_Chip-Seq_HPCs_Mouse1.22927008
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22664262
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.22560303
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22004554
87GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21395975
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.20691969
89MYC_19829295_ChIP-Seq_ESCs_Human1.20285002
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20027835
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19996993
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19875830
93KDM2B_26808549_Chip-Seq_REH_Human1.19443310
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18714998
95REST_21632747_ChIP-Seq_MESCs_Mouse1.18569627
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.16951285
97ETV1_20927104_ChIP-Seq_GIST48_Human1.16945901
98NANOG_20526341_ChIP-Seq_ESCs_Human1.16156214
99LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.15662339
100AR_21572438_ChIP-Seq_LNCaP_Human1.15182058
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14874515
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14591807
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14496770
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.14475271
105SMRT_27268052_Chip-Seq_Bcells_Human1.14377823
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13937331
107HOXB7_26014856_ChIP-Seq_BT474_Human1.13283677
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12961697
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12873721
110GABP_17652178_ChIP-ChIP_JURKAT_Human1.11488772
111ERA_21632823_ChIP-Seq_H3396_Human1.11148589
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10666348
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10385648
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10134719
115RUNX2_22187159_ChIP-Seq_PCA_Human1.10079987
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10016547
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.09699992
118TAF2_19829295_ChIP-Seq_ESCs_Human1.09529553
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09434727
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09308157
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09023254
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08576055
123P53_22387025_ChIP-Seq_ESCs_Mouse1.08402677
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.08393988
125FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08276007
126FOXA1_25329375_ChIP-Seq_VCAP_Human1.08276007
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08102070
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.08068277
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.07901655
130TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07775251
131FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07409616
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06983640
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06833762
134GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06757071
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.05496611
136GATA3_21867929_ChIP-Seq_TH1_Mouse1.05321212
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05196699
138* OCT4_20526341_ChIP-Seq_ESCs_Human1.05063260
139SPI1_26923725_Chip-Seq_HPCs_Mouse1.04338082
140RBPJ_21746931_ChIP-Seq_IB4_Human1.04310577
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03986975
142ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03673010
143LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02663242
144P300_18555785_Chip-Seq_ESCs_Mouse1.01984188
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01556156
146TBL1_22424771_ChIP-Seq_293T_Human1.01216537
147GATA3_27048872_Chip-Seq_THYMUS_Human1.01022583
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00800383
149KLF4_18555785_Chip-Seq_ESCs_Mouse1.00766588
150FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00646436
151MYC_18940864_ChIP-ChIP_HL60_Human1.00420507
152NFYB_21822215_ChIP-Seq_K562_Human0.99929571
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99830268
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.98926150
155FLI1_21867929_ChIP-Seq_CD8_Mouse0.97976388
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97535188
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.97341324
158GF1B_26923725_Chip-Seq_HPCs_Mouse0.96491354
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96459724
160CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96428428
161ZFX_18555785_Chip-Seq_ESCs_Mouse0.96066468
162ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95823635
163STAT1_20625510_ChIP-Seq_HELA_Human0.94640382
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92367494
165PU1_27457419_Chip-Seq_LIVER_Mouse0.92066098
166PHF8_20622853_ChIP-Seq_HELA_Human0.91621338
167SMAD4_21799915_ChIP-Seq_A2780_Human0.90421331
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89158826
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.88747704
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88707865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.59145082
2MP0001929_abnormal_gametogenesis5.21840559
3MP0008877_abnormal_DNA_methylation4.35847498
4MP0002653_abnormal_ependyma_morphology3.58489213
5MP0002210_abnormal_sex_determination3.49208565
6MP0008875_abnormal_xenobiotic_pharmacok3.35087402
7MP0002161_abnormal_fertility/fecundity3.00588729
8MP0001145_abnormal_male_reproductive2.91523360
9MP0002160_abnormal_reproductive_system2.84582847
10MP0005670_abnormal_white_adipose2.63165710
11MP0000653_abnormal_sex_gland2.58609940
12MP0003136_yellow_coat_color2.50196929
13MP0005671_abnormal_response_to2.17406898
14MP0005623_abnormal_meninges_morphology2.17088817
15MP0003195_calcinosis2.04331003
16MP0004043_abnormal_pH_regulation2.01520753
17MP0005410_abnormal_fertilization13.7271022
18MP0001968_abnormal_touch/_nociception1.99042966
19MP0008872_abnormal_physiological_respon1.84329391
20MP0008004_abnormal_stomach_pH1.77031318
21MP0001984_abnormal_olfaction1.76081413
22MP0001485_abnormal_pinna_reflex1.61236245
23MP0005389_reproductive_system_phenotype1.59858547
24MP0008057_abnormal_DNA_replication1.59763039
25MP0005084_abnormal_gallbladder_morpholo1.58654638
26MP0004885_abnormal_endolymph1.58308230
27MP0002928_abnormal_bile_duct1.49640118
28MP0002132_abnormal_respiratory_system1.48382446
29MP0001501_abnormal_sleep_pattern1.47965353
30MP0009745_abnormal_behavioral_response1.43816795
31MP0004142_abnormal_muscle_tone1.42805509
32MP0001835_abnormal_antigen_presentation1.42276983
33MP0001800_abnormal_humoral_immune1.41910027
34MP0005647_abnormal_sex_gland1.41664551
35MP0008058_abnormal_DNA_repair1.39573907
36MP0008995_early_reproductive_senescence1.37835155
37MP0004742_abnormal_vestibular_system1.36579758
38MP0001790_abnormal_immune_system1.36434297
39MP0005387_immune_system_phenotype1.36434297
40MP0002234_abnormal_pharynx_morphology1.32174617
41MP0005645_abnormal_hypothalamus_physiol1.30397262
42MP0000569_abnormal_digit_pigmentation1.30271537
43MP0003252_abnormal_bile_duct1.29337918
44MP0004133_heterotaxia1.29230327
45MP0005310_abnormal_salivary_gland1.25924345
46MP0000372_irregular_coat_pigmentation1.24264316
47MP0002735_abnormal_chemical_nociception1.23341617
48MP0002282_abnormal_trachea_morphology1.22755517
49MP0001765_abnormal_ion_homeostasis1.22580943
50MP0009785_altered_susceptibility_to1.19807585
51MP0002272_abnormal_nervous_system1.18145835
52MP0006082_CNS_inflammation1.17875877
53MP0001486_abnormal_startle_reflex1.14559515
54MP0003880_abnormal_central_pattern1.13771937
55MP0002723_abnormal_immune_serum1.12143841
56MP0008789_abnormal_olfactory_epithelium1.12103917
57MP0005083_abnormal_biliary_tract1.11261320
58MP0009764_decreased_sensitivity_to1.08753373
59MP0002837_dystrophic_cardiac_calcinosis1.08649640
60MP0005174_abnormal_tail_pigmentation1.07753031
61MP0005646_abnormal_pituitary_gland1.07722493
62MP0001986_abnormal_taste_sensitivity1.03851768
63MP0002420_abnormal_adaptive_immunity1.01093102
64MP0006072_abnormal_retinal_apoptosis0.99079065
65MP0001819_abnormal_immune_cell0.98523920
66MP0008007_abnormal_cellular_replicative0.98362295
67MP0001970_abnormal_pain_threshold0.97540736
68MP0002148_abnormal_hypersensitivity_rea0.97423743
69MP0002452_abnormal_antigen_presenting0.97195570
70MP0002277_abnormal_respiratory_mucosa0.96450163
71MP0003786_premature_aging0.95416432
72MP0005085_abnormal_gallbladder_physiolo0.93829069
73MP0002405_respiratory_system_inflammati0.93098522
74MP0002572_abnormal_emotion/affect_behav0.92757630
75MP0005000_abnormal_immune_tolerance0.91740601
76MP0005025_abnormal_response_to0.91044770
77MP0003646_muscle_fatigue0.88498516
78MP0003806_abnormal_nucleotide_metabolis0.88113693
79MP0000427_abnormal_hair_cycle0.88037244
80MP0003115_abnormal_respiratory_system0.87243258
81MP0001764_abnormal_homeostasis0.86521889
82MP0003866_abnormal_defecation0.86088641
83MP0003283_abnormal_digestive_organ0.85358782
84MP0005551_abnormal_eye_electrophysiolog0.84535494
85MP0002095_abnormal_skin_pigmentation0.84355824
86MP0003878_abnormal_ear_physiology0.84111145
87MP0005377_hearing/vestibular/ear_phenot0.84111145
88MP0002067_abnormal_sensory_capabilities0.84110975
89MP0006276_abnormal_autonomic_nervous0.83334269
90MP0000383_abnormal_hair_follicle0.83094769
91MP0002064_seizures0.79392984
92MP0004147_increased_porphyrin_level0.78211048
93MP0000026_abnormal_inner_ear0.77732144
94MP0001963_abnormal_hearing_physiology0.76993654
95MP0005379_endocrine/exocrine_gland_phen0.76835661
96MP0003436_decreased_susceptibility_to0.76542427
97MP0002102_abnormal_ear_morphology0.76251323
98MP0009046_muscle_twitch0.75667739
99MP0005195_abnormal_posterior_eye0.74742423
100MP0005253_abnormal_eye_physiology0.71298146
101MP0001873_stomach_inflammation0.70835346
102MP0004233_abnormal_muscle_weight0.69509923
103MP0010094_abnormal_chromosome_stability0.68531853
104MP0004381_abnormal_hair_follicle0.68514169
105MP0003950_abnormal_plasma_membrane0.67183904
106MP0005636_abnormal_mineral_homeostasis0.67067455
107MP0001851_eye_inflammation0.66234758
108MP0001293_anophthalmia0.65044284
109MP0005391_vision/eye_phenotype0.61133802
110MP0003011_delayed_dark_adaptation0.60771925
111MP0001119_abnormal_female_reproductive0.55671524
112MP0002693_abnormal_pancreas_physiology0.54627586
113MP0001270_distended_abdomen0.53101195
114MP0002876_abnormal_thyroid_physiology0.52754946
115MP0004019_abnormal_vitamin_homeostasis0.51909229
116MP0002638_abnormal_pupillary_reflex0.51823619
117MP0003763_abnormal_thymus_physiology0.50883855
118MP0003879_abnormal_hair_cell0.50653269
119MP0000358_abnormal_cell_content/0.50400658
120MP0001545_abnormal_hematopoietic_system0.49295744
121MP0005397_hematopoietic_system_phenotyp0.49295744
122MP0003699_abnormal_female_reproductive0.49073660
123MP0001944_abnormal_pancreas_morphology0.48516197
124MP0001919_abnormal_reproductive_system0.48064190
125MP0003942_abnormal_urinary_system0.47602512
126MP0005075_abnormal_melanosome_morpholog0.45627608
127MP0000613_abnormal_salivary_gland0.43597863
128MP0002909_abnormal_adrenal_gland0.43410285
129MP0003111_abnormal_nucleus_morphology0.42783350
130MP0001727_abnormal_embryo_implantation0.42110662
131MP0000049_abnormal_middle_ear0.37521617
132MP0002168_other_aberrant_phenotype0.37151545
133MP0002092_abnormal_eye_morphology0.36535372
134MP0003943_abnormal_hepatobiliary_system0.36083551
135MP0004782_abnormal_surfactant_physiolog0.35866373
136MP0001324_abnormal_eye_pigmentation0.35747172
137MP0002163_abnormal_gland_morphology0.35522338
138MP0003936_abnormal_reproductive_system0.35149379
139MP0009115_abnormal_fat_cell0.33929028
140MP0003861_abnormal_nervous_system0.33844026
141MP0002295_abnormal_pulmonary_circulatio0.33766291
142MP0003045_fibrosis0.32780677
143MP0004808_abnormal_hematopoietic_stem0.31507400
144MP0002109_abnormal_limb_morphology0.30542351
145MP0002133_abnormal_respiratory_system0.30459055
146MP0005388_respiratory_system_phenotype0.30459055
147MP0002736_abnormal_nociception_after0.30128155
148MP0003693_abnormal_embryo_hatching0.29486948
149MP0002116_abnormal_craniofacial_bone0.29483925
150MP0000685_abnormal_immune_system0.29153718
151MP0000534_abnormal_ureter_morphology0.28952327
152MP0000631_abnormal_neuroendocrine_gland0.28814286
153MP0005395_other_phenotype0.27339156
154MP0001502_abnormal_circadian_rhythm0.26809724
155MP0004145_abnormal_muscle_electrophysio0.26078425
156MP0003724_increased_susceptibility_to0.26022726
157MP0002557_abnormal_social/conspecific_i0.25382487
158MP0002938_white_spotting0.24785137

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.85247598
2Abnormal respiratory epithelium morphology (HP:0012253)9.85247598
3Rhinitis (HP:0012384)9.26513644
4Chronic bronchitis (HP:0004469)7.57161094
5Nasal polyposis (HP:0100582)6.01237612
6Bronchiectasis (HP:0002110)5.66440499
7Infertility (HP:0000789)5.65014913
8Abnormality of the nasal mucosa (HP:0000433)4.88763113
9Bronchitis (HP:0012387)4.39780036
10Nephronophthisis (HP:0000090)3.84074802
11Male infertility (HP:0003251)3.81843468
12Recurrent sinusitis (HP:0011108)3.78887458
13Recurrent otitis media (HP:0000403)3.18484178
14Congenital stationary night blindness (HP:0007642)3.14394733
15Tubulointerstitial nephritis (HP:0001970)3.07671307
16Pancreatic fibrosis (HP:0100732)3.03664975
17Molar tooth sign on MRI (HP:0002419)2.93348601
18Abnormality of midbrain morphology (HP:0002418)2.93348601
19Abnormality of the renal medulla (HP:0100957)2.90691379
20Supernumerary spleens (HP:0009799)2.88988553
21True hermaphroditism (HP:0010459)2.88418726
22Abnormal rod and cone electroretinograms (HP:0008323)2.80878564
23Medial flaring of the eyebrow (HP:0010747)2.76873632
24Chronic sinusitis (HP:0011109)2.75970554
25Type II lissencephaly (HP:0007260)2.69953354
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67028033
27Congenital hepatic fibrosis (HP:0002612)2.45444887
28Attenuation of retinal blood vessels (HP:0007843)2.45080615
29Median cleft lip (HP:0000161)2.45019540
30Tubulointerstitial abnormality (HP:0001969)2.41483035
31Postaxial foot polydactyly (HP:0001830)2.40998642
32Tubular atrophy (HP:0000092)2.37124757
33Abolished electroretinogram (ERG) (HP:0000550)2.35016624
34Bile duct proliferation (HP:0001408)2.33733678
35Abnormal biliary tract physiology (HP:0012439)2.33733678
36Stomatitis (HP:0010280)2.33648501
37Cystic liver disease (HP:0006706)2.30014625
38Recurrent bronchitis (HP:0002837)2.28192665
39Abnormal spermatogenesis (HP:0008669)2.27599937
40Abnormality of dentin (HP:0010299)2.25934502
41Elevated erythrocyte sedimentation rate (HP:0003565)2.25776118
42Chronic otitis media (HP:0000389)2.23728157
43Pancreatic cysts (HP:0001737)2.22069723
44Fibular hypoplasia (HP:0003038)2.19061690
45Occipital encephalocele (HP:0002085)2.16784403
46Facial cleft (HP:0002006)2.13450908
47Abnormality of the dental root (HP:0006486)2.07952916
48Taurodontia (HP:0000679)2.07952916
49Abnormality of permanent molar morphology (HP:0011071)2.07952916
50Congenital primary aphakia (HP:0007707)2.02714811
51Bony spicule pigmentary retinopathy (HP:0007737)2.02628555
52Renal cortical cysts (HP:0000803)2.02042837
53Congenital, generalized hypertrichosis (HP:0004540)2.00163106
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3221374
55Abnormal respiratory motile cilium physiology (HP:0012261)11.6072405
56Absent/shortened dynein arms (HP:0200106)11.1283533
57Dynein arm defect of respiratory motile cilia (HP:0012255)11.1283533
58Abnormal ciliary motility (HP:0012262)10.3411124
59Gait imbalance (HP:0002141)1.98911061
60Abnormality of the dental pulp (HP:0006479)1.97625728
61Decreased circulating renin level (HP:0003351)1.96527745
62Abnormality of molar (HP:0011077)1.95282988
63Abnormality of molar morphology (HP:0011070)1.95282988
64Furrowed tongue (HP:0000221)1.94948123
65Retinal dysplasia (HP:0007973)1.93161652
66Abnormal delayed hypersensitivity skin test (HP:0002963)1.91377445
67Pendular nystagmus (HP:0012043)1.89122767
68Oculomotor apraxia (HP:0000657)1.86890282
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.86765587
70Stage 5 chronic kidney disease (HP:0003774)1.84215581
71Retrobulbar optic neuritis (HP:0100654)1.83974516
72Optic neuritis (HP:0100653)1.83974516
73Myositis (HP:0100614)1.83423026
74Nephrogenic diabetes insipidus (HP:0009806)1.82986340
75Tubulointerstitial fibrosis (HP:0005576)1.82159331
76Hypoproteinemia (HP:0003075)1.78614105
77Abnormality of T cell number (HP:0011839)1.77503247
78Postaxial hand polydactyly (HP:0001162)1.72215936
79Abnormality of the renal cortex (HP:0011035)1.69449164
80Impulsivity (HP:0100710)1.67639484
81Azoospermia (HP:0000027)1.65024879
82Aplasia/hypoplasia of the uterus (HP:0008684)1.64973615
83Abnormal drinking behavior (HP:0030082)1.64383838
84Polydipsia (HP:0001959)1.64383838
85Large for gestational age (HP:0001520)1.63690994
86Abnormality of macular pigmentation (HP:0008002)1.63465433
87Gonadotropin excess (HP:0000837)1.62733499
88Autoimmune thrombocytopenia (HP:0001973)1.61955752
89Cerebellar dysplasia (HP:0007033)1.61261692
90Severe combined immunodeficiency (HP:0004430)1.59870503
91Mitochondrial inheritance (HP:0001427)1.58491426
92Stomach cancer (HP:0012126)1.57790330
93Male pseudohermaphroditism (HP:0000037)1.57230071
94Progressive cerebellar ataxia (HP:0002073)1.56833561
95Aplasia/Hypoplasia of the lens (HP:0008063)1.54779197
96Inability to walk (HP:0002540)1.54776093
97Gaze-evoked nystagmus (HP:0000640)1.54767493
98Keratoconus (HP:0000563)1.53913923
99Increased corneal curvature (HP:0100692)1.53913923
1003-Methylglutaconic aciduria (HP:0003535)1.53551642
101Broad distal phalanx of finger (HP:0009836)1.53444069
102Preaxial hand polydactyly (HP:0001177)1.52825274
103Genital tract atresia (HP:0001827)1.50099424
104Hypoalbuminemia (HP:0003073)1.49614349
105Abnormal albumin level (HP:0012116)1.49614349
106Abnormality of the lower motor neuron (HP:0002366)1.49610959
107Congenital sensorineural hearing impairment (HP:0008527)1.49575469
108Decreased electroretinogram (ERG) amplitude (HP:0000654)1.49289913
109Hyperventilation (HP:0002883)1.48640195
110Vaginal atresia (HP:0000148)1.48616210
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.48184192
112Poor coordination (HP:0002370)1.47802692
113Abdominal situs inversus (HP:0003363)1.47131598
114Abnormality of abdominal situs (HP:0011620)1.47131598
115Dyschromatopsia (HP:0007641)1.47065549
116Chronic hepatic failure (HP:0100626)1.45505666
117Amyotrophic lateral sclerosis (HP:0007354)1.45406472
118Nephropathy (HP:0000112)1.44529734
119Short nail (HP:0001799)1.43549445
12011 pairs of ribs (HP:0000878)1.39906322
121Abnormality of renal excretion (HP:0011036)1.35010553
122Aplasia/Hypoplasia of the fibula (HP:0006492)1.33335417
123Decreased central vision (HP:0007663)1.31500337
124Short thorax (HP:0010306)1.31431701
125Short ribs (HP:0000773)1.28975684
126Anencephaly (HP:0002323)1.28495121
127Sclerocornea (HP:0000647)1.27751943
128Bell-shaped thorax (HP:0001591)1.27230775
129Renal dysplasia (HP:0000110)1.26559698
130Bifid tongue (HP:0010297)1.26276158
131Constricted visual fields (HP:0001133)1.22636458
132Asplenia (HP:0001746)1.20412491
133Abnormal urine output (HP:0012590)1.19597943
134Polycystic kidney dysplasia (HP:0000113)1.17073035
135Polyuria (HP:0000103)1.13668135
136Absent epiphyses (HP:0010577)1.10421987
137Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.10421987
138J-shaped sella turcica (HP:0002680)1.10063289
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.09312688
140Atelectasis (HP:0100750)1.02290440
141Retinitis pigmentosa (HP:0000510)1.02046709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.60748112
2PDK47.60748112
3TESK15.18281670
4PDK24.71129594
5PRKD34.41189445
6MAPK154.03788743
7PNCK4.00181373
8TLK13.70960501
9TAOK33.21290763
10ICK3.14116542
11MAP4K22.42601934
12INSRR2.15578751
13NUAK12.08488637
14OXSR11.99505878
15PTK2B1.95147604
16WNK41.88048472
17NEK21.68152227
18ACVR1B1.66343564
19MAP4K11.51601087
20CAMKK21.50418418
21WEE11.47603804
22STK381.45179892
23PASK1.37310673
24CDK191.33358375
25STK391.31467595
26DYRK1B1.26245848
27GRK61.24968562
28ADRBK11.21558503
29IRAK11.17837163
30DYRK31.12855867
31TESK21.11854766
32TNK21.09304923
33MAP3K41.09161920
34STK31.07756339
35NME11.04563868
36GRK11.00662589
37PLK40.98206435
38SYK0.93457781
39CSK0.90254912
40IKBKE0.89177250
41DAPK20.88607584
42IKBKB0.88463184
43KIT0.86081787
44RIPK40.85264542
45PAK30.83726326
46FES0.81873164
47DYRK20.80519940
48CDK30.77175220
49IRAK20.75365594
50STK110.75140921
51PINK10.74242569
52LCK0.73948076
53VRK10.72610123
54STK100.71887687
55LYN0.70893622
56TTK0.70835048
57MAPKAPK30.68387011
58MAP2K70.67570065
59WNK10.67223085
60STK38L0.66455584
61BTK0.65766665
62PIK3CA0.65317558
63EEF2K0.63669813
64PRKCE0.61996516
65TNIK0.60723538
66CHEK20.60179171
67PRKCG0.56869590
68MAP2K20.56600050
69PDK10.55886230
70GRK70.54853250
71BCR0.54292972
72SIK20.53958376
73CDC70.53202171
74PIK3CG0.53151034
75MST40.50027687
76CCNB10.48261668
77MAP3K70.48205041
78PAK20.48155861
79AURKA0.47721323
80BMPR1B0.47448050
81HCK0.46178671
82IRAK40.45492904
83NTRK20.45394103
84PLK20.44268282
85MAPKAPK50.44161719
86STK160.43919614
87BRSK20.43255946
88PRKACA0.43172253
89TRIM280.42774985
90TGFBR10.42170916
91CAMK10.41142037
92BUB10.41088609
93JAK30.40510166
94MKNK20.38946318
95BCKDK0.38608578
96WNK30.38513158
97CAMK2A0.38055828
98PKN10.37719301
99PAK10.37238762
100PRKCI0.35652456
101BMPR20.35323630
102PLK10.33793457
103CHUK0.32363062
104PIM20.32357270
105BRAF0.32042697
106ATR0.32011668
107CHEK10.30503267
108PRKCH0.29977616
109PRKCZ0.29956249
110CASK0.29383208
111ATM0.29367616
112GRK50.28959447
113ZAP700.28897647
114ERBB20.28853759
115ADRBK20.27970160
116BRSK10.26036805
117TYRO30.25695743
118MUSK0.24840404
119NEK60.24181514
120PRKAA10.23714806
121NLK0.22752410
122YES10.22696528
123KDR0.22024766
124CDC42BPA0.21601571
125SRPK10.21038336
126TEC0.20630445
127ITK0.20041798
128FRK0.19073620
129CSNK2A10.18113659
130CAMK1G0.18046993
131RPS6KA40.18042365
132MAP2K60.17394461
133TIE10.16768999
134ERBB30.16325632
135PAK40.16305202
136RPS6KB10.15737731
137PDPK10.13588629
138RPS6KA10.13305827
139MARK30.12692827
140ROCK10.12666280
141TXK0.12467138
142ZAK0.12403435
143PRKCQ0.12369698
144CAMKK10.09203879
145PRKG10.08933519
146RPS6KA50.08104513
147EPHA20.07875724
148RPS6KA20.07845084
149PRKACG0.07739806
150PRKD20.07333936
151GSK3A0.07169223
152DYRK1A0.07118220
153PRKCA0.06723385
154MAPK130.06635441
155CSNK2A20.06522748
156MTOR0.06118673
157AURKB0.06035257

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.10927265
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.23259601
3Pyruvate metabolism_Homo sapiens_hsa006202.83643396
4Fanconi anemia pathway_Homo sapiens_hsa034602.81651361
5Linoleic acid metabolism_Homo sapiens_hsa005912.79099015
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.72591774
7Fatty acid biosynthesis_Homo sapiens_hsa000612.72154647
8Basal transcription factors_Homo sapiens_hsa030222.70710898
9Phototransduction_Homo sapiens_hsa047442.56214835
10Caffeine metabolism_Homo sapiens_hsa002322.36550380
11Huntingtons disease_Homo sapiens_hsa050162.35854886
12Glucagon signaling pathway_Homo sapiens_hsa049222.27063997
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.22140029
14Graft-versus-host disease_Homo sapiens_hsa053322.21494302
15Nitrogen metabolism_Homo sapiens_hsa009102.16111062
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.15189544
17Antigen processing and presentation_Homo sapiens_hsa046122.12800110
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04339009
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98565338
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.98294742
21Type I diabetes mellitus_Homo sapiens_hsa049401.93876479
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90862733
23Oxidative phosphorylation_Homo sapiens_hsa001901.88661725
24Purine metabolism_Homo sapiens_hsa002301.86823611
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86719857
26Dorso-ventral axis formation_Homo sapiens_hsa043201.84052974
27Selenocompound metabolism_Homo sapiens_hsa004501.79952717
28Propanoate metabolism_Homo sapiens_hsa006401.78825174
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.66167174
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62250711
31Glycerolipid metabolism_Homo sapiens_hsa005611.62153983
32Fructose and mannose metabolism_Homo sapiens_hsa000511.60321842
33Nicotine addiction_Homo sapiens_hsa050331.59039570
34Butanoate metabolism_Homo sapiens_hsa006501.54660225
35Amphetamine addiction_Homo sapiens_hsa050311.52395560
36Asthma_Homo sapiens_hsa053101.50696389
37Olfactory transduction_Homo sapiens_hsa047401.50442620
38Pentose phosphate pathway_Homo sapiens_hsa000301.50176083
39Pyrimidine metabolism_Homo sapiens_hsa002401.45776252
40PPAR signaling pathway_Homo sapiens_hsa033201.44948589
41Oocyte meiosis_Homo sapiens_hsa041141.42550779
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.40001112
43Ether lipid metabolism_Homo sapiens_hsa005651.36307296
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34519084
45Parkinsons disease_Homo sapiens_hsa050121.34075454
46Arachidonic acid metabolism_Homo sapiens_hsa005901.33109788
47Histidine metabolism_Homo sapiens_hsa003401.31630317
48Mineral absorption_Homo sapiens_hsa049781.26932920
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23379524
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22952849
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22857525
52Hematopoietic cell lineage_Homo sapiens_hsa046401.19059205
53Insulin secretion_Homo sapiens_hsa049111.17832989
54Regulation of autophagy_Homo sapiens_hsa041401.15902960
55Fat digestion and absorption_Homo sapiens_hsa049751.11864593
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.11423765
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10864041
58beta-Alanine metabolism_Homo sapiens_hsa004101.06053339
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03542126
60Peroxisome_Homo sapiens_hsa041461.03482947
61Homologous recombination_Homo sapiens_hsa034401.02589795
62Glycosaminoglycan degradation_Homo sapiens_hsa005311.00877856
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99305325
64Sphingolipid metabolism_Homo sapiens_hsa006000.98052606
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97856352
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97572252
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.96962612
68Tryptophan metabolism_Homo sapiens_hsa003800.95433070
69Nucleotide excision repair_Homo sapiens_hsa034200.94628428
70RNA transport_Homo sapiens_hsa030130.93759548
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93627036
72Morphine addiction_Homo sapiens_hsa050320.92331805
73Hedgehog signaling pathway_Homo sapiens_hsa043400.92176896
74Renin secretion_Homo sapiens_hsa049240.90872939
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90027258
76RNA polymerase_Homo sapiens_hsa030200.88527297
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88525677
78Glutathione metabolism_Homo sapiens_hsa004800.88247077
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85366171
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81330777
81Estrogen signaling pathway_Homo sapiens_hsa049150.81163528
82Systemic lupus erythematosus_Homo sapiens_hsa053220.79740977
83Taste transduction_Homo sapiens_hsa047420.78683119
84Alzheimers disease_Homo sapiens_hsa050100.77805692
85Serotonergic synapse_Homo sapiens_hsa047260.74742392
86Collecting duct acid secretion_Homo sapiens_hsa049660.74097269
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73650863
88mRNA surveillance pathway_Homo sapiens_hsa030150.73262254
89DNA replication_Homo sapiens_hsa030300.71475440
90Inositol phosphate metabolism_Homo sapiens_hsa005620.70007733
91Staphylococcus aureus infection_Homo sapiens_hsa051500.69750957
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68189273
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.67857949
94Cardiac muscle contraction_Homo sapiens_hsa042600.67786728
95Thyroid hormone synthesis_Homo sapiens_hsa049180.66152990
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66134226
97ABC transporters_Homo sapiens_hsa020100.64302962
98Legionellosis_Homo sapiens_hsa051340.63512884
99Carbon metabolism_Homo sapiens_hsa012000.62455025
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61666549
101Salivary secretion_Homo sapiens_hsa049700.60161915
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.59534866
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59022288
104Base excision repair_Homo sapiens_hsa034100.57923068
105RNA degradation_Homo sapiens_hsa030180.55706724
106Autoimmune thyroid disease_Homo sapiens_hsa053200.54372547
107Proteasome_Homo sapiens_hsa030500.53717418
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53480309
109Tyrosine metabolism_Homo sapiens_hsa003500.53421126
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52736151
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51780935
112Cell cycle_Homo sapiens_hsa041100.51699736
113African trypanosomiasis_Homo sapiens_hsa051430.51528090
114Spliceosome_Homo sapiens_hsa030400.50682766
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50325937
116Glutamatergic synapse_Homo sapiens_hsa047240.48890093
117Non-homologous end-joining_Homo sapiens_hsa034500.48655598
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47942176
119T cell receptor signaling pathway_Homo sapiens_hsa046600.46266181
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46046450
121Ovarian steroidogenesis_Homo sapiens_hsa049130.45818862
122Circadian rhythm_Homo sapiens_hsa047100.45397085
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45340540
124Calcium signaling pathway_Homo sapiens_hsa040200.45300002
125Measles_Homo sapiens_hsa051620.44881672
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44870925
127Allograft rejection_Homo sapiens_hsa053300.43230131
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42120284
129GABAergic synapse_Homo sapiens_hsa047270.41507484
130Metabolic pathways_Homo sapiens_hsa011000.40878278
131Phenylalanine metabolism_Homo sapiens_hsa003600.38290631
132Cocaine addiction_Homo sapiens_hsa050300.36536250
133Circadian entrainment_Homo sapiens_hsa047130.33963798
134Primary immunodeficiency_Homo sapiens_hsa053400.33686968
135Pancreatic secretion_Homo sapiens_hsa049720.32717449
136Wnt signaling pathway_Homo sapiens_hsa043100.32417052
137Epstein-Barr virus infection_Homo sapiens_hsa051690.32353883
138Protein export_Homo sapiens_hsa030600.31859974
139Ribosome_Homo sapiens_hsa030100.31010950
140Leishmaniasis_Homo sapiens_hsa051400.30449752
141cAMP signaling pathway_Homo sapiens_hsa040240.30077451
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30058901
143Alcoholism_Homo sapiens_hsa050340.29537575
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.29420925
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26999905
146Retinol metabolism_Homo sapiens_hsa008300.26874378
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26785152
148Vitamin digestion and absorption_Homo sapiens_hsa049770.26716057
149Other glycan degradation_Homo sapiens_hsa005110.26422828
150Endocytosis_Homo sapiens_hsa041440.25974194
151Rheumatoid arthritis_Homo sapiens_hsa053230.25845465
152Chemical carcinogenesis_Homo sapiens_hsa052040.25262839

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