TTC17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)9.61413578
2water-soluble vitamin biosynthetic process (GO:0042364)6.03564098
3protein K48-linked deubiquitination (GO:0071108)5.14026410
4prostate gland growth (GO:0060736)5.09480405
5cobalamin metabolic process (GO:0009235)4.46590721
6cell proliferation in forebrain (GO:0021846)4.27247575
7protein complex biogenesis (GO:0070271)4.18555922
8phospholipid homeostasis (GO:0055091)4.15825577
9histone deubiquitination (GO:0016578)4.14329621
10forebrain morphogenesis (GO:0048853)4.13425034
11limb development (GO:0060173)3.99470923
12appendage development (GO:0048736)3.99470923
13behavioral response to nicotine (GO:0035095)3.96214767
14somite development (GO:0061053)3.92223644
15negative regulation of systemic arterial blood pressure (GO:0003085)3.78059446
16mitochondrial respiratory chain complex assembly (GO:0033108)3.75816214
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.68298994
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.67355527
19purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.67355527
20positive regulation of endothelial cell differentiation (GO:0045603)3.65051986
21dicarboxylic acid biosynthetic process (GO:0043650)3.64774629
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.58952622
23response to lipoprotein particle (GO:0055094)3.58165462
24presynaptic membrane assembly (GO:0097105)3.56518931
25alpha-linolenic acid metabolic process (GO:0036109)3.55647434
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54131663
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.54131663
28NADH dehydrogenase complex assembly (GO:0010257)3.54131663
29kidney morphogenesis (GO:0060993)3.49479684
30positive regulation of fatty acid beta-oxidation (GO:0032000)3.48332224
31positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.48089980
32replication fork processing (GO:0031297)3.46550621
33positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.46349863
34cellular response to BMP stimulus (GO:0071773)3.44725927
35response to BMP (GO:0071772)3.44725927
36negative regulation of membrane potential (GO:0045837)3.44242902
37pharyngeal system development (GO:0060037)3.42873487
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.41998935
39interkinetic nuclear migration (GO:0022027)3.37651005
40regulation of fatty acid beta-oxidation (GO:0031998)3.36456253
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34466077
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34466077
43lysine catabolic process (GO:0006554)3.33036143
44lysine metabolic process (GO:0006553)3.33036143
45regulation of sequestering of triglyceride (GO:0010889)3.32966612
46neural tube formation (GO:0001841)3.32312316
47dentate gyrus development (GO:0021542)3.31409523
48epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.31317909
49otic vesicle formation (GO:0030916)3.28969497
50regulation of cholesterol homeostasis (GO:2000188)3.28058613
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25250493
52branching involved in labyrinthine layer morphogenesis (GO:0060670)3.23052844
53presynaptic membrane organization (GO:0097090)3.22963416
54sulfation (GO:0051923)3.19321232
55negative regulation of fibrinolysis (GO:0051918)3.18543657
56urea cycle (GO:0000050)3.16961736
57urea metabolic process (GO:0019627)3.16961736
58lung-associated mesenchyme development (GO:0060484)3.16938390
59kynurenine metabolic process (GO:0070189)3.16836981
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16650422
61misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.16599439
62magnesium ion transport (GO:0015693)3.15608369
63positive regulation of cardiac muscle cell differentiation (GO:2000727)3.13652231
64high-density lipoprotein particle remodeling (GO:0034375)3.12062345
65DNA deamination (GO:0045006)3.09081916
66positive regulation of gamma-delta T cell activation (GO:0046645)3.03477095
67antigen processing and presentation of endogenous antigen (GO:0019883)2.99872245
68embryonic epithelial tube formation (GO:0001838)2.97950530
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97281012
70L-phenylalanine metabolic process (GO:0006558)2.97281012
71indolalkylamine metabolic process (GO:0006586)2.93243588
72middle ear morphogenesis (GO:0042474)2.91541200
73reverse cholesterol transport (GO:0043691)2.91307411
74resolution of meiotic recombination intermediates (GO:0000712)2.91204753
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91183292
76L-phenylalanine catabolic process (GO:0006559)2.91183292
77positive regulation of lipid catabolic process (GO:0050996)2.91177813
782-oxoglutarate metabolic process (GO:0006103)2.90721615
79complement activation, alternative pathway (GO:0006957)2.89283018
80epithelial cilium movement (GO:0003351)2.89240288
81bile acid biosynthetic process (GO:0006699)2.87651198
82regulation of triglyceride catabolic process (GO:0010896)2.85720662
83regulation of endothelial cell differentiation (GO:0045601)2.85667542
84aorta morphogenesis (GO:0035909)2.85034679
85lateral sprouting from an epithelium (GO:0060601)2.84062973
86peptidyl-glutamic acid carboxylation (GO:0017187)2.83312422
87protein carboxylation (GO:0018214)2.83312422
88positive regulation of fatty acid oxidation (GO:0046321)2.82840768
89protein import into peroxisome matrix (GO:0016558)2.82767346
90homocysteine metabolic process (GO:0050667)2.82500223
91regulation of fibrinolysis (GO:0051917)2.80817628
92nonmotile primary cilium assembly (GO:0035058)2.80636696
93regulation of protein activation cascade (GO:2000257)2.80486518
94plasma lipoprotein particle assembly (GO:0034377)2.79978286
95aggressive behavior (GO:0002118)2.79913632
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79839898
97protein-lipid complex assembly (GO:0065005)2.79424603
98spindle assembly involved in mitosis (GO:0090307)2.79374191
99phospholipid efflux (GO:0033700)2.78946638
100epithelial tube formation (GO:0072175)2.78659888
101regulation of cardioblast proliferation (GO:0003264)2.78462098
102regulation of secondary heart field cardioblast proliferation (GO:0003266)2.78462098
103pituitary gland development (GO:0021983)2.78452854
104negative regulation of sterol transport (GO:0032372)2.78162915
105negative regulation of cholesterol transport (GO:0032375)2.78162915
106base-excision repair, AP site formation (GO:0006285)2.76804337
107nitrogen cycle metabolic process (GO:0071941)2.76481868
108regulation of gamma-delta T cell differentiation (GO:0045586)2.75887668
109negative regulation of response to food (GO:0032096)2.74264004
110negative regulation of appetite (GO:0032099)2.74264004
111aromatic amino acid family catabolic process (GO:0009074)2.74025255
112positive regulation of histone deacetylation (GO:0031065)2.72334054
113tryptophan catabolic process (GO:0006569)2.72292990
114indole-containing compound catabolic process (GO:0042436)2.72292990
115indolalkylamine catabolic process (GO:0046218)2.72292990
116growth hormone receptor signaling pathway (GO:0060396)2.71283279
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70855068
118protein-lipid complex remodeling (GO:0034368)2.70264981
119macromolecular complex remodeling (GO:0034367)2.70264981
120plasma lipoprotein particle remodeling (GO:0034369)2.70264981
121cholesterol efflux (GO:0033344)2.68977936
122fatty acid transmembrane transport (GO:1902001)2.67700730
123epithelial cell maturation (GO:0002070)2.67345484
124seminiferous tubule development (GO:0072520)2.66571969
125plasma lipoprotein particle clearance (GO:0034381)2.66403690
126regulation of acrosome reaction (GO:0060046)2.65570865
127embryonic skeletal joint morphogenesis (GO:0060272)2.63976368
128histone H2A monoubiquitination (GO:0035518)2.62723771
129axoneme assembly (GO:0035082)2.62656974
130photoreceptor cell development (GO:0042461)2.61848089
131regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.61459274
132regulation of complement activation (GO:0030449)2.60952445
133tryptophan metabolic process (GO:0006568)2.60298591
134dorsal/ventral axis specification (GO:0009950)2.60292057
135negative regulation of astrocyte differentiation (GO:0048712)2.59934953
136cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59413217
137negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59103130
138preassembly of GPI anchor in ER membrane (GO:0016254)2.57583747
139bile acid metabolic process (GO:0008206)2.57020576
140regulation of receptor biosynthetic process (GO:0010869)2.56683749
141negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.56593797
142sulfur amino acid catabolic process (GO:0000098)2.56206634
143regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.56151895
144vitamin biosynthetic process (GO:0009110)2.56019800
145carnitine shuttle (GO:0006853)2.55978933
146glyoxylate metabolic process (GO:0046487)2.55370164
147sodium ion export (GO:0071436)2.54663389
148intraciliary transport (GO:0042073)2.53780770
149regulation of gamma-delta T cell activation (GO:0046643)2.53233045
150intestinal cholesterol absorption (GO:0030299)2.52631881
151outer ear morphogenesis (GO:0042473)2.52062643
152acylglycerol homeostasis (GO:0055090)2.51837217
153triglyceride homeostasis (GO:0070328)2.51837217
154determination of left/right symmetry (GO:0007368)2.51544530
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51085729
156head development (GO:0060322)2.50717235
157cilium morphogenesis (GO:0060271)2.49821544
158protein polyglutamylation (GO:0018095)2.48803422
159regulation of fatty acid oxidation (GO:0046320)2.48414909
160positive regulation of oligodendrocyte differentiation (GO:0048714)2.47746711
161brown fat cell differentiation (GO:0050873)2.47619454
162thyroid gland development (GO:0030878)2.47301192
163cysteine metabolic process (GO:0006534)2.46699195
164regulation of interleukin-12 biosynthetic process (GO:0045075)2.45361773
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44926591
166pyrimidine nucleotide catabolic process (GO:0006244)2.44567587
167regulation of cholesterol storage (GO:0010885)2.44395362
168mesenchymal-epithelial cell signaling (GO:0060638)2.44390779
169cellular modified amino acid catabolic process (GO:0042219)2.44385248
170negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43888279
171eye photoreceptor cell development (GO:0042462)2.43707076
172negative regulation of lipid transport (GO:0032369)2.43073930
173aspartate family amino acid catabolic process (GO:0009068)2.43019664
174valine metabolic process (GO:0006573)2.42859742
175macroautophagy (GO:0016236)2.42539452
176positive thymic T cell selection (GO:0045059)2.41536223
177negative regulation of lipase activity (GO:0060192)2.40661258
178positive regulation of glycolytic process (GO:0045821)2.39717431
179regulation of lipid catabolic process (GO:0050994)2.39654341
180regulation of cholesterol esterification (GO:0010872)2.39177732
181protein-lipid complex subunit organization (GO:0071825)2.36356202
182amino-acid betaine metabolic process (GO:0006577)2.36053070
183regulation of glucose import in response to insulin stimulus (GO:2001273)2.34044538
184fatty acid homeostasis (GO:0055089)2.33976305
185plasma lipoprotein particle organization (GO:0071827)2.33691447
186regulation of cholesterol biosynthetic process (GO:0045540)2.33613352
187cellular response to growth hormone stimulus (GO:0071378)2.33500141
188glutamate metabolic process (GO:0006536)2.32563836
189lipoprotein transport (GO:0042953)2.31743171
190cellular potassium ion homeostasis (GO:0030007)2.27133361
191oxaloacetate metabolic process (GO:0006107)2.26856339
192positive regulation of triglyceride metabolic process (GO:0090208)2.24923441
193lipoprotein metabolic process (GO:0042157)2.22742437
194plasma membrane repair (GO:0001778)2.21455806
195positive regulation of B cell differentiation (GO:0045579)2.20275623
196complement activation, classical pathway (GO:0006958)2.20250287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.71152299
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.09936419
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.69299581
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.63170859
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32913372
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.26793083
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.21737098
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.18040781
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.13796894
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.94531917
11GBX2_23144817_ChIP-Seq_PC3_Human2.93482525
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88024544
13FUS_26573619_Chip-Seq_HEK293_Human2.79880506
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.74124172
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73076451
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63402395
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63323423
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54076255
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.53458125
20IRF1_19129219_ChIP-ChIP_H3396_Human2.45869735
21TAF15_26573619_Chip-Seq_HEK293_Human2.36997400
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.36908628
23IGF1R_20145208_ChIP-Seq_DFB_Human2.28815375
24VDR_22108803_ChIP-Seq_LS180_Human2.15266893
25RUNX_20019798_ChIP-Seq_JUKART_Human2.14291569
26ZNF274_21170338_ChIP-Seq_K562_Hela2.13456526
27EWS_26573619_Chip-Seq_HEK293_Human2.03145845
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98414816
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93934948
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91797140
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87395659
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86419319
33P300_19829295_ChIP-Seq_ESCs_Human1.84742527
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84411226
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83326279
36CLOCK_20551151_ChIP-Seq_293T_Human1.80762378
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.75605898
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74274481
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72082494
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.69527817
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68928505
42STAT3_23295773_ChIP-Seq_U87_Human1.65693796
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62014988
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.61731041
45* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60830744
46EZH2_22144423_ChIP-Seq_EOC_Human1.60110002
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57956154
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.56490527
49GATA1_22025678_ChIP-Seq_K562_Human1.55727272
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55023811
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53628997
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53502610
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.53500994
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51990848
55CBP_20019798_ChIP-Seq_JUKART_Human1.51990848
56SPI1_23127762_ChIP-Seq_K562_Human1.51505125
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51390296
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.49624529
59KDM2B_26808549_Chip-Seq_DND41_Human1.49400685
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49356169
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47775649
62TCF7_22412390_ChIP-Seq_EML_Mouse1.47620553
63SCL_19346495_ChIP-Seq_HPC-7_Human1.46764991
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45881559
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44572342
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44478316
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42317055
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40053890
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39071236
70MYC_22102868_ChIP-Seq_BL_Human1.39054969
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38876839
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38372435
73* TCF4_23295773_ChIP-Seq_U87_Human1.37663222
74DROSHA_22980978_ChIP-Seq_HELA_Human1.37168137
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36654973
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35867864
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.35070408
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34863064
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34289544
80ER_23166858_ChIP-Seq_MCF-7_Human1.34217100
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33891446
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33555658
83* NANOG_18555785_Chip-Seq_ESCs_Mouse1.33100864
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32832341
85RNF2_27304074_Chip-Seq_NSC_Mouse1.32605000
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.31629419
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31202451
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.30627366
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.30613468
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30463706
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28188782
92* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27541056
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26859850
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25409332
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.25018924
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.25018924
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24940680
98MAF_26560356_Chip-Seq_TH1_Human1.24511279
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.23507607
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.22703703
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.22282460
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.21690575
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21561714
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.20857994
105ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20683821
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20425912
107GATA2_19941826_ChIP-Seq_K562_Human1.20260621
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20013222
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.19071197
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18996526
111GATA1_19941826_ChIP-Seq_K562_Human1.18885072
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18534745
113ESR1_21235772_ChIP-Seq_MCF-7_Human1.18417389
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.17930605
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17808039
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.16576350
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16479652
118* P53_22387025_ChIP-Seq_ESCs_Mouse1.16370636
119AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15037713
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.14977526
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14415351
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14145646
123TP53_16413492_ChIP-PET_HCT116_Human1.14094106
124PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13548258
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13430971
126VDR_21846776_ChIP-Seq_THP-1_Human1.12848747
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.11828883
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11817506
129CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11251567
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10901357
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10780743
132MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10125754
133AR_25329375_ChIP-Seq_VCAP_Human1.09707369
134FOXO3_23340844_ChIP-Seq_DLD1_Human1.09492862
135KDM2B_26808549_Chip-Seq_JURKAT_Human1.09271687
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07649297
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.07181770
138LXR_22292898_ChIP-Seq_THP-1_Human1.07159150
139* P300_18555785_Chip-Seq_ESCs_Mouse1.06448170
140RUNX2_22187159_ChIP-Seq_PCA_Human1.06067327
141* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05465762
142P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04721029
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04426236
144CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04411694
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03723942
146KDM2B_26808549_Chip-Seq_K562_Human1.03145062
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02856105
148TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02395294
149KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01220113
150* RXR_22108803_ChIP-Seq_LS180_Human1.01059808
151* TAL1_26923725_Chip-Seq_HPCs_Mouse1.01027660
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00997934
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00543296
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00543296
155TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00207088
156STAT3_18555785_Chip-Seq_ESCs_Mouse1.00177802
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99701707
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99467830
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99186077
160MYC_18940864_ChIP-ChIP_HL60_Human0.98780356
161* NMYC_18555785_Chip-Seq_ESCs_Mouse0.97429471
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97174667
163CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96771218
164TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96684704
165UTX_26944678_Chip-Seq_JUKART_Human0.96571191
166ELK1_19687146_ChIP-ChIP_HELA_Human0.96147429
167MYB_26560356_Chip-Seq_TH1_Human0.96029901
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96027809
169TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95663812
170KDM2B_26808549_Chip-Seq_REH_Human0.95592060
171RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95461719
172NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95200138
173RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94489732
174ELK3_25401928_ChIP-Seq_HUVEC_Human0.94309778
175EP300_21415370_ChIP-Seq_HL-1_Mouse0.93904718
176PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93201355
177CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91789024
178NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90322519
179EGR1_19374776_ChIP-ChIP_THP-1_Human0.90243271
180PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88748622
181VDR_24787735_ChIP-Seq_THP-1_Human0.87840783
182ARNT_22903824_ChIP-Seq_MCF-7_Human0.87069447
183VDR_24763502_ChIP-Seq_THP-1_Human0.86978782
184GATA3_27048872_Chip-Seq_THYMUS_Human0.86936007
185EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85848318
186* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85690226
187WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84334140
188* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84317385
189P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83885859
190AHR_22903824_ChIP-Seq_MCF-7_Human0.83577081
191ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83018775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.43835943
2MP0005360_urolithiasis4.29031258
3MP0002139_abnormal_hepatobiliary_system4.18527319
4MP0005365_abnormal_bile_salt3.90421208
5MP0003122_maternal_imprinting3.59208194
6MP0004510_myositis3.52342928
7MP0005085_abnormal_gallbladder_physiolo3.04573793
8MP0006292_abnormal_olfactory_placode2.89072748
9MP0003890_abnormal_embryonic-extraembry2.76988765
10MP0003252_abnormal_bile_duct2.65165963
11MP0000537_abnormal_urethra_morphology2.63932625
12MP0003121_genomic_imprinting2.55126285
13MP0009840_abnormal_foam_cell2.50924450
14MP0002102_abnormal_ear_morphology2.50787799
15MP0008875_abnormal_xenobiotic_pharmacok2.49751623
16MP0005646_abnormal_pituitary_gland2.40778814
17MP0003191_abnormal_cellular_cholesterol2.40132611
18MP0010329_abnormal_lipoprotein_level2.38592973
19MP0003172_abnormal_lysosome_physiology2.15001511
20MP0001666_abnormal_nutrient_absorption2.12261058
21MP0004130_abnormal_muscle_cell2.09261577
22MP0000049_abnormal_middle_ear2.08014887
23MP0003705_abnormal_hypodermis_morpholog2.07002995
24MP0005367_renal/urinary_system_phenotyp2.06392046
25MP0000516_abnormal_urinary_system2.06392046
26MP0003937_abnormal_limbs/digits/tail_de2.00321473
27MP0004185_abnormal_adipocyte_glucose1.98642963
28MP0005083_abnormal_biliary_tract1.97004515
29MP0003300_gastrointestinal_ulcer1.95087551
30MP0003787_abnormal_imprinting1.90379254
31MP0004133_heterotaxia1.79023522
32MP0003279_aneurysm1.66634510
33MP0003868_abnormal_feces_composition1.66253212
34MP0003567_abnormal_fetal_cardiomyocyte1.63782682
35MP0009780_abnormal_chondrocyte_physiolo1.63164406
36MP0002876_abnormal_thyroid_physiology1.62029304
37MP0002837_dystrophic_cardiac_calcinosis1.58824774
38MP0003011_delayed_dark_adaptation1.58569118
39MP0004084_abnormal_cardiac_muscle1.55921040
40MP0002166_altered_tumor_susceptibility1.55404089
41MP0000609_abnormal_liver_physiology1.55141022
42MP0003646_muscle_fatigue1.53917492
43MP0003942_abnormal_urinary_system1.52943967
44MP0002160_abnormal_reproductive_system1.50953506
45MP0000631_abnormal_neuroendocrine_gland1.50571954
46MP0003938_abnormal_ear_development1.48548439
47MP0005670_abnormal_white_adipose1.48057424
48MP0000604_amyloidosis1.47665428
49MP0002282_abnormal_trachea_morphology1.39993630
50MP0000013_abnormal_adipose_tissue1.38145837
51MP0001485_abnormal_pinna_reflex1.37721421
52MP0001661_extended_life_span1.37369988
53MP0005551_abnormal_eye_electrophysiolog1.36340367
54MP0008877_abnormal_DNA_methylation1.35949171
55MP0003303_peritoneal_inflammation1.35876558
56MP0000749_muscle_degeneration1.35550178
57MP0000751_myopathy1.34605874
58MP0005389_reproductive_system_phenotype1.33123536
59MP0003724_increased_susceptibility_to1.33104030
60MP0002118_abnormal_lipid_homeostasis1.33025980
61MP0004142_abnormal_muscle_tone1.32682776
62MP0002736_abnormal_nociception_after1.31688109
63MP0003119_abnormal_digestive_system1.29486835
64MP0005464_abnormal_platelet_physiology1.27819054
65MP0009384_cardiac_valve_regurgitation1.27350726
66MP0002938_white_spotting1.27230558
67MP0008789_abnormal_olfactory_epithelium1.26463291
68MP0003656_abnormal_erythrocyte_physiolo1.23706509
69MP0005058_abnormal_lysosome_morphology1.23088084
70MP0009697_abnormal_copulation1.23064161
71MP0008961_abnormal_basal_metabolism1.22957083
72MP0004742_abnormal_vestibular_system1.21715150
73MP0006072_abnormal_retinal_apoptosis1.21560031
74MP0003436_decreased_susceptibility_to1.21375191
75MP0005408_hypopigmentation1.20111684
76MP0001968_abnormal_touch/_nociception1.18889744
77MP0002653_abnormal_ependyma_morphology1.18640556
78MP0005332_abnormal_amino_acid1.17341279
79MP0003045_fibrosis1.16769109
80MP0004036_abnormal_muscle_relaxation1.16519405
81MP0005330_cardiomyopathy1.13207549
82MP0004947_skin_inflammation1.12941268
83MP0001800_abnormal_humoral_immune1.12523376
84MP0001984_abnormal_olfaction1.12264936
85MP0005319_abnormal_enzyme/_coenzyme1.11495172
86MP0009765_abnormal_xenobiotic_induced1.11290252
87MP0001835_abnormal_antigen_presentation1.11147336
88MP0002233_abnormal_nose_morphology1.09877949
89MP0000428_abnormal_craniofacial_morphol1.07022789
90MP0005671_abnormal_response_to1.05625738
91MP0000427_abnormal_hair_cycle1.04486353
92MP0004087_abnormal_muscle_fiber1.04234436
93MP0008995_early_reproductive_senescence1.03583246
94MP0002269_muscular_atrophy1.02841470
95MP0003329_amyloid_beta_deposits1.02657381
96MP0003183_abnormal_peptide_metabolism1.01318426
97MP0004215_abnormal_myocardial_fiber1.01313108
98MP0004885_abnormal_endolymph1.01239803
99MP0003566_abnormal_cell_adhesion1.00845860
100MP0009764_decreased_sensitivity_to0.99800826
101MP0010368_abnormal_lymphatic_system0.99622679
102MP0004145_abnormal_muscle_electrophysio0.98605917
103MP0001270_distended_abdomen0.97778747
104MP0002928_abnormal_bile_duct0.96828462
105MP0003091_abnormal_cell_migration0.96476950
106MP0009278_abnormal_bone_marrow0.96435448
107MP0005253_abnormal_eye_physiology0.96087581
108MP0000685_abnormal_immune_system0.95270720
109MP0001963_abnormal_hearing_physiology0.95048216
110MP0010630_abnormal_cardiac_muscle0.94950152
111MP0000778_abnormal_nervous_system0.93486178
112MP0002932_abnormal_joint_morphology0.93139324
113MP0002751_abnormal_autonomic_nervous0.92563982
114MP0003936_abnormal_reproductive_system0.92030376
115MP0000026_abnormal_inner_ear0.91353453
116MP0003755_abnormal_palate_morphology0.90729384
117MP0001286_abnormal_eye_development0.90630971
118MP0009763_increased_sensitivity_to0.90456996
119MP0000371_diluted_coat_color0.90123934
120MP0005386_behavior/neurological_phenoty0.89445369
121MP0004924_abnormal_behavior0.89445369
122MP0002138_abnormal_hepatobiliary_system0.88966352
123MP0001873_stomach_inflammation0.88652386
124MP0001958_emphysema0.87243968
125MP0005076_abnormal_cell_differentiation0.86443172
126MP0002419_abnormal_innate_immunity0.86124267
127MP0000598_abnormal_liver_morphology0.86123192
128MP0005195_abnormal_posterior_eye0.85990640
129MP0002006_tumorigenesis0.85769031
130MP0004808_abnormal_hematopoietic_stem0.85350672
131MP0002909_abnormal_adrenal_gland0.85226351
132MP0002557_abnormal_social/conspecific_i0.83035906
133MP0005387_immune_system_phenotype0.82926803
134MP0001790_abnormal_immune_system0.82926803
135MP0008469_abnormal_protein_level0.81988159
136MP0009250_abnormal_appendicular_skeleto0.81629089
137MP0004859_abnormal_synaptic_plasticity0.81507428
138MP0005584_abnormal_enzyme/coenzyme_acti0.81245454
139MP0010678_abnormal_skin_adnexa0.80458900
140MP0005666_abnormal_adipose_tissue0.80363103
141MP0002452_abnormal_antigen_presenting0.79704387
142MP0000534_abnormal_ureter_morphology0.79420662
143MP0000681_abnormal_thyroid_gland0.78857376
144MP0001502_abnormal_circadian_rhythm0.78716006
145MP0001486_abnormal_startle_reflex0.78594063
146MP0009053_abnormal_anal_canal0.78308426
147MP0008775_abnormal_heart_ventricle0.77185092
148MP0002972_abnormal_cardiac_muscle0.76839724
149MP0005023_abnormal_wound_healing0.76754365
150MP0001544_abnormal_cardiovascular_syste0.76488411
151MP0005385_cardiovascular_system_phenoty0.76488411
152MP0000639_abnormal_adrenal_gland0.76325712
153MP0001853_heart_inflammation0.75916724
154MP0005220_abnormal_exocrine_pancreas0.75794482
155MP0002090_abnormal_vision0.75233315
156MP0000383_abnormal_hair_follicle0.74236385
157MP0001919_abnormal_reproductive_system0.74088021
158MP0008874_decreased_physiological_sensi0.73958860
159MP0001845_abnormal_inflammatory_respons0.73708666
160MP0003075_altered_response_to0.73345980
161MP0002135_abnormal_kidney_morphology0.73161888
162MP0003315_abnormal_perineum_morphology0.72921289
163MP0006276_abnormal_autonomic_nervous0.72467196
164MP0002735_abnormal_chemical_nociception0.72406794
165MP0002723_abnormal_immune_serum0.71867316
166MP0000230_abnormal_systemic_arterial0.71179743
167MP0001533_abnormal_skeleton_physiology0.71069299
168MP0010155_abnormal_intestine_physiology0.70660849
169MP0000767_abnormal_smooth_muscle0.69997692
170MP0003690_abnormal_glial_cell0.69740421
171MP0004134_abnormal_chest_morphology0.68803747
172MP0009785_altered_susceptibility_to0.68579936
173MP0009643_abnormal_urine_homeostasis0.66621345
174MP0001293_anophthalmia0.66407837
175MP0002420_abnormal_adaptive_immunity0.66399425
176MP0005334_abnormal_fat_pad0.66255212
177MP0008872_abnormal_physiological_respon0.65774065
178MP0008438_abnormal_cutaneous_collagen0.65659886
179MP0001440_abnormal_grooming_behavior0.65448668
180MP0009115_abnormal_fat_cell0.65018853
181MP0004484_altered_response_of0.64993197
182MP0009046_muscle_twitch0.64304308
183MP0002109_abnormal_limb_morphology0.62937647
184MP0002116_abnormal_craniofacial_bone0.62305332
185MP0002752_abnormal_somatic_nervous0.61793379

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)7.52522523
2Stenosis of the external auditory canal (HP:0000402)4.66803694
3Deep venous thrombosis (HP:0002625)4.47344781
4Hyperglycinemia (HP:0002154)4.28257848
5Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.16740422
6Short 1st metacarpal (HP:0010034)4.16740422
7Methylmalonic acidemia (HP:0002912)3.94668616
8Meningioma (HP:0002858)3.66344530
9Abnormality of the 1st metacarpal (HP:0010009)3.65381788
10Abnormality of the nasal septum (HP:0000419)3.51660509
11Methylmalonic aciduria (HP:0012120)3.47174523
12Xanthomatosis (HP:0000991)3.45819539
13Abnormality of the proximal phalanges of the hand (HP:0009834)3.26388016
14Ectopic kidney (HP:0000086)3.23081612
15Abnormality of the renal collecting system (HP:0004742)3.23069395
16Complement deficiency (HP:0004431)3.21396411
17Myocardial infarction (HP:0001658)3.21080506
18Gingival bleeding (HP:0000225)3.18373878
19Carpal bone hypoplasia (HP:0001498)3.17441751
20Morphological abnormality of the middle ear (HP:0008609)3.04923872
21Hypoalphalipoproteinemia (HP:0003233)2.89423586
22Mitral stenosis (HP:0001718)2.86426365
23Genetic anticipation (HP:0003743)2.85974775
24Intrahepatic cholestasis (HP:0001406)2.84112212
25Nephronophthisis (HP:0000090)2.79788124
26Hyperlipoproteinemia (HP:0010980)2.78374123
27Abnormality of DNA repair (HP:0003254)2.75959911
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.75603144
29Abnormality of the common coagulation pathway (HP:0010990)2.74756941
30Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73997748
31Pancreatic cysts (HP:0001737)2.67965251
32Short phalanx of the thumb (HP:0009660)2.66874495
33Ketosis (HP:0001946)2.65552902
34Short hallux (HP:0010109)2.64982727
35Cerebral aneurysm (HP:0004944)2.56258014
36Abnormality of the phalanges of the 2nd finger (HP:0009541)2.56158378
37Abnormality of the renal medulla (HP:0100957)2.56038576
38Aplasia/Hypoplasia of the hallux (HP:0008362)2.53433449
39Prolonged partial thromboplastin time (HP:0003645)2.52177478
40Hyperammonemia (HP:0001987)2.51345246
41Pancreatic fibrosis (HP:0100732)2.51078309
42Dysmetric saccades (HP:0000641)2.49599760
43Hypolipoproteinemia (HP:0010981)2.48673740
44Abnormality of the vitamin B12 metabolism (HP:0004341)2.45906182
45Aortic aneurysm (HP:0004942)2.44970905
46Abnormality of the middle phalanges of the toes (HP:0010183)2.42135978
47Periodontitis (HP:0000704)2.41387434
48Volvulus (HP:0002580)2.40598208
49Hypercholesterolemia (HP:0003124)2.40124201
50Neoplasm of the lung (HP:0100526)2.38224667
51Vitreoretinal degeneration (HP:0000655)2.36955732
52Skin nodule (HP:0200036)2.36698291
53Hypobetalipoproteinemia (HP:0003563)2.36526016
54Abnormality of the fingertips (HP:0001211)2.36524990
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.36293267
56Joint hemorrhage (HP:0005261)2.35785084
57Thyroiditis (HP:0100646)2.35429808
58Epidermoid cyst (HP:0200040)2.34586852
59True hermaphroditism (HP:0010459)2.34473320
60Abnormality of vitamin B metabolism (HP:0004340)2.34176362
61Limb-girdle muscle atrophy (HP:0003797)2.34166695
62Abnormality of the phalanges of the 5th finger (HP:0004213)2.32294342
63Asymmetric septal hypertrophy (HP:0001670)2.31867607
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.31864701
65Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.30825783
66Tented upper lip vermilion (HP:0010804)2.30109476
67Abnormality of midbrain morphology (HP:0002418)2.29105567
68Molar tooth sign on MRI (HP:0002419)2.29105567
69Broad metatarsal (HP:0001783)2.27207910
70Exercise-induced myalgia (HP:0003738)2.26465656
71Right ventricular cardiomyopathy (HP:0011663)2.23590492
72Short tibia (HP:0005736)2.22608913
73Chronic hepatic failure (HP:0100626)2.21881958
74Ketoacidosis (HP:0001993)2.20729964
75Aneurysm (HP:0002617)2.20686398
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.20682400
77Abnormality of serine family amino acid metabolism (HP:0010894)2.20147736
78Abnormality of glycine metabolism (HP:0010895)2.20147736
79Hematochezia (HP:0002573)2.19734969
80Abnormality of the parathyroid morphology (HP:0011766)2.19568888
81Neoplasm of the adrenal cortex (HP:0100641)2.18932583
82Synostosis of carpal bones (HP:0005048)2.17452945
83Abnormality of the renal cortex (HP:0011035)2.17145268
84Neoplasm of the respiratory system (HP:0100606)2.16705239
85Medial flaring of the eyebrow (HP:0010747)2.15605895
86Abnormality of cochlea (HP:0000375)2.15542361
87Absent thumb (HP:0009777)2.15428161
88Esophageal varix (HP:0002040)2.13982796
89Hypoglycemic coma (HP:0001325)2.12286513
90Oligomenorrhea (HP:0000876)2.12242787
91Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12129939
92Syncope (HP:0001279)2.10030487
93Abnormality of complement system (HP:0005339)2.09524142
94Recurrent bacterial skin infections (HP:0005406)2.09354675
95Short 4th metacarpal (HP:0010044)2.08959789
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08959789
97Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.08047011
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06512185
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06200473
100Long toe (HP:0010511)2.05153025
101Bundle branch block (HP:0011710)2.04429552
102Lip pit (HP:0100267)2.03577382
103Chorioretinal atrophy (HP:0000533)2.03167535
104Abolished electroretinogram (ERG) (HP:0000550)2.02501288
105Colitis (HP:0002583)2.02374870
106Benign neoplasm of the central nervous system (HP:0100835)2.02146821
107Renal hypoplasia (HP:0000089)1.98659448
108Hemiplegia (HP:0002301)1.98343707
109Nephrogenic diabetes insipidus (HP:0009806)1.98201206
110Cystic liver disease (HP:0006706)1.97970020
111Tachypnea (HP:0002789)1.97959151
112Abnormality of the intrinsic pathway (HP:0010989)1.97817148
113Congenital primary aphakia (HP:0007707)1.96872263
114Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.96050543
115Hypoplasia of the ulna (HP:0003022)1.95204388
116Tubulointerstitial nephritis (HP:0001970)1.94650478
117Atrial fibrillation (HP:0005110)1.94273344
118Duplicated collecting system (HP:0000081)1.94034042
119Renal cortical cysts (HP:0000803)1.93741352
120Increased connective tissue (HP:0009025)1.92099342
121Fatigue (HP:0012378)1.91958814
122Gait imbalance (HP:0002141)1.91007434
123Acanthocytosis (HP:0001927)1.89379619
124Impaired platelet aggregation (HP:0003540)1.87414649
125Abnormal platelet function (HP:0011869)1.87414649
126Progressive cerebellar ataxia (HP:0002073)1.86719676
127Mitral valve prolapse (HP:0001634)1.86401188
128Genital tract atresia (HP:0001827)1.86326595
129Ventricular tachycardia (HP:0004756)1.85578823
130Increased corneal curvature (HP:0100692)1.85150390
131Keratoconus (HP:0000563)1.85150390
132Recurrent abscess formation (HP:0002722)1.84700368
133Vaginal atresia (HP:0000148)1.84604914
134Exercise-induced muscle cramps (HP:0003710)1.83465578
135Ectopia lentis (HP:0001083)1.83219596
136Short femoral neck (HP:0100864)1.83139787
137Protrusio acetabuli (HP:0003179)1.82877990
138Porencephaly (HP:0002132)1.82833336
1392-3 toe syndactyly (HP:0004691)1.82715303
140Osteomalacia (HP:0002749)1.82195981
141Cholelithiasis (HP:0001081)1.80729119
142Cutaneous finger syndactyly (HP:0010554)1.80431174
143Abnormality of fatty-acid metabolism (HP:0004359)1.80310550
144Congenital sensorineural hearing impairment (HP:0008527)1.80046197
145Synostosis involving the elbow (HP:0003938)1.79669886
146Humeroradial synostosis (HP:0003041)1.79669886
147Narrow palate (HP:0000189)1.79638088
148Sensorimotor neuropathy (HP:0007141)1.79511224
149Nephritis (HP:0000123)1.78663492
150Gaze-evoked nystagmus (HP:0000640)1.78248357
151Horseshoe kidney (HP:0000085)1.78244359
152Systemic lupus erythematosus (HP:0002725)1.77723027
153Sudden death (HP:0001699)1.76175711
154Spontaneous abortion (HP:0005268)1.76153472
155Scapular winging (HP:0003691)1.75136264
156Melanoma (HP:0002861)1.74912923
157Striae distensae (HP:0001065)1.74906538
158Arterial thrombosis (HP:0004420)1.74381084
159Hypoplasia of the thymus (HP:0000778)1.72742540
160Recurrent gram-negative bacterial infections (HP:0005420)1.72734011
161Epistaxis (HP:0000421)1.72149634
162Macroorchidism (HP:0000053)1.71997855
163Menorrhagia (HP:0000132)1.71166156
164Enlarged penis (HP:0000040)1.70900660
165Glomerulonephritis (HP:0000099)1.70822408
166Prolonged QT interval (HP:0001657)1.70526876
167Primary atrial arrhythmia (HP:0001692)1.70513467
168Amyloidosis (HP:0011034)1.69653130
169Hyporeflexia of lower limbs (HP:0002600)1.69370806
170Congenital, generalized hypertrichosis (HP:0004540)1.69199592
171Abnormality of the calf musculature (HP:0001430)1.68997894
172Fat malabsorption (HP:0002630)1.68788508
173Aplasia/Hypoplasia of the sternum (HP:0006714)1.67054427
174Autoimmune thrombocytopenia (HP:0001973)1.65391286
175Hypoplasia of the uterus (HP:0000013)1.65090657
176Short humerus (HP:0005792)1.65000338
177Pendular nystagmus (HP:0012043)1.64984394
178Peritonitis (HP:0002586)1.64343539
179Increased mean platelet volume (HP:0011877)1.64334380
180Symphalangism affecting the phalanges of the hand (HP:0009773)1.64331092
181Short foot (HP:0001773)1.63971272
182Distal upper limb amyotrophy (HP:0007149)1.63893372
183Upper limb amyotrophy (HP:0009129)1.63893372
184Long nose (HP:0003189)1.62714609
185Aqueductal stenosis (HP:0002410)1.62450121
186Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62372466
187Inflammation of the large intestine (HP:0002037)1.61316049
188Abnormal gallbladder morphology (HP:0012437)1.61222876
189Thrombophlebitis (HP:0004418)1.60128051
190Supraventricular tachycardia (HP:0004755)1.59918715
191Global brain atrophy (HP:0002283)1.59819805
192Lymphangioma (HP:0100764)1.59597110
193Ventricular arrhythmia (HP:0004308)1.59585959
194Myoglobinuria (HP:0002913)1.59435769
195Aortic dissection (HP:0002647)1.59339362
196Frequent falls (HP:0002359)1.58522617
197Stroke (HP:0001297)1.58487255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.79485005
2FGFR23.37928149
3ERN13.12403951
4PKN23.03071756
5TRIB32.94427635
6RIPK12.56211522
7SIK12.56001460
8CAMK1D2.44691529
9GRK12.34476295
10TTN2.33861180
11MAP4K12.24899383
12FGFR42.23152755
13TYK22.18645566
14JAK12.17828259
15TAOK32.10898874
16MAP3K42.02104387
17NUAK12.01967647
18CAMK1G1.95073992
19WNK31.92774834
20CASK1.87646600
21MAP3K131.82409250
22MAP3K71.69290010
23TGFBR21.61672328
24EPHB11.57202359
25CAMKK21.56314138
26EEF2K1.51492269
27SGK31.49347621
28MAP4K21.48212989
29BCKDK1.40728296
30MAPK131.36211854
31BCR1.31509503
32DYRK21.27987805
33ADRBK21.26987413
34CDK121.25481001
35PTK61.25153383
36CAMKK11.24658171
37MAP3K141.21991525
38LATS11.20746172
39BMPR1B1.18979798
40CSF1R1.18355201
41PIK3CA1.17879043
42TBK11.17513605
43FGFR31.17363155
44PRKAA21.17237110
45MAP2K71.16525784
46BRD41.16331208
47IKBKE1.14563610
48PRKCH1.13289406
49MKNK11.12427459
50SGK21.11396420
51ERBB31.08735968
52SIK21.08661852
53TAOK11.08433453
54TAOK21.07665662
55EPHB21.04967885
56DYRK31.03153607
57TXK1.02450474
58HCK1.00011191
59INSRR0.99947416
60JAK20.99713063
61JAK30.99034191
62ITK0.96150618
63DAPK20.95811500
64MAP3K100.95439642
65CDK80.92623356
66MKNK20.92283075
67RET0.92164617
68STK380.92006520
69CSNK1A1L0.91560337
70ZAP700.91108021
71CHUK0.90432205
72ZAK0.90121318
73ATR0.90056150
74STK390.89448636
75TLK10.89159259
76STK110.88246048
77AKT30.87560834
78CAMK40.87393148
79PRKAA10.86321023
80PDK20.86027038
81PLK20.85229062
82TIE10.84361851
83MAP2K60.84216570
84BRSK20.84107811
85KIT0.83788323
86PDGFRA0.83570260
87PIK3CG0.82494701
88MAPK110.82316650
89STK100.81926244
90ERBB20.81790673
91PDK10.80278036
92LMTK20.80044312
93NLK0.79769702
94FLT30.78543692
95CSK0.77956180
96FES0.77228457
97GRK60.77056293
98WNK40.74637203
99EPHA30.74086472
100PRKCE0.72892601
101IKBKB0.72866406
102CSNK1G10.72851530
103CDK190.72569230
104MAP2K30.72297722
105MAPK120.70768555
106MTOR0.69424615
107PDGFRB0.69323794
108PLK40.68978340
109DYRK1A0.67521098
110FGFR10.64371041
111NEK90.63744203
112ATM0.63058197
113CAMK10.62946175
114BMX0.62864055
115DMPK0.62659482
116BTK0.61792608
117RPS6KA50.61300942
118WNK10.61290176
119PINK10.60055810
120CSNK1D0.59712119
121OXSR10.58406333
122RPS6KB10.57836775
123HIPK20.57597820
124PTK20.57583293
125PTK2B0.57332344
126PHKG20.57227538
127PHKG10.57227538
128CSNK1A10.57190271
129PRKG20.56425276
130CSNK1G20.55738400
131TEC0.55607967
132PASK0.54020284
133PDPK10.54000947
134PAK30.53840051
135MAP2K40.52373419
136SYK0.51743229
137MAPK150.51451934
138CSNK1G30.51266476
139CDK90.50547296
140ALK0.50209135
141RPS6KA20.48901467
142MAP3K10.48255343
143PRKD20.48249346
144PRKD10.47634323
145SGK4940.46708191
146SGK2230.46708191
147LYN0.46571400
148SGK10.45927738
149LRRK20.45151933
150NTRK20.44864926
151ADRBK10.44378457
152TGFBR10.42153548
153EPHA40.41198874
154MAP3K90.41149979
155RPS6KA40.40600779
156LCK0.40228059
157PNCK0.39870638
158GRK70.39604657
159PRKACG0.39461019
160PRKACA0.38858833
161IGF1R0.38180734
162MAPK30.37798189
163FYN0.37699594
164PRKCQ0.36737879
165MUSK0.36604310

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.78159277
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55864990
3Nitrogen metabolism_Homo sapiens_hsa009103.53220382
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.12695250
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.67088838
6Arginine biosynthesis_Homo sapiens_hsa002202.44044165
7RNA degradation_Homo sapiens_hsa030182.35450131
8Protein export_Homo sapiens_hsa030602.32597567
9Fanconi anemia pathway_Homo sapiens_hsa034602.07704013
10Renin-angiotensin system_Homo sapiens_hsa046142.03430099
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98932814
12Complement and coagulation cascades_Homo sapiens_hsa046101.88795738
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.87230621
14Fatty acid degradation_Homo sapiens_hsa000711.80000740
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79379716
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.78227005
17Linoleic acid metabolism_Homo sapiens_hsa005911.77198560
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67886445
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66732669
20Caffeine metabolism_Homo sapiens_hsa002321.64934229
21Staphylococcus aureus infection_Homo sapiens_hsa051501.63642528
22PPAR signaling pathway_Homo sapiens_hsa033201.61557193
23Phototransduction_Homo sapiens_hsa047441.61480549
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58712584
25Lysine degradation_Homo sapiens_hsa003101.58489567
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57394388
27Bile secretion_Homo sapiens_hsa049761.55109266
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55065091
29Tryptophan metabolism_Homo sapiens_hsa003801.53441769
30Basal cell carcinoma_Homo sapiens_hsa052171.52176437
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51506983
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.42115382
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37853450
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36447727
35Protein digestion and absorption_Homo sapiens_hsa049741.36367592
36ABC transporters_Homo sapiens_hsa020101.36315477
37TGF-beta signaling pathway_Homo sapiens_hsa043501.32623525
38Insulin resistance_Homo sapiens_hsa049311.31601545
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28435420
40Ether lipid metabolism_Homo sapiens_hsa005651.27360196
41Fatty acid metabolism_Homo sapiens_hsa012121.25837401
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25517736
43Basal transcription factors_Homo sapiens_hsa030221.24404773
44Starch and sucrose metabolism_Homo sapiens_hsa005001.23223593
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.17048352
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16157171
47Nicotine addiction_Homo sapiens_hsa050331.08849493
48Type II diabetes mellitus_Homo sapiens_hsa049301.08808505
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08627273
50Dilated cardiomyopathy_Homo sapiens_hsa054141.08563179
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08198441
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07712427
53Propanoate metabolism_Homo sapiens_hsa006401.06497231
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02136553
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00077391
56Steroid biosynthesis_Homo sapiens_hsa001000.97913055
57Osteoclast differentiation_Homo sapiens_hsa043800.94035962
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.93690627
59Fat digestion and absorption_Homo sapiens_hsa049750.92143233
60Regulation of autophagy_Homo sapiens_hsa041400.91813663
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89860043
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89572614
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88845685
64B cell receptor signaling pathway_Homo sapiens_hsa046620.88782891
65Taste transduction_Homo sapiens_hsa047420.88659054
66Hedgehog signaling pathway_Homo sapiens_hsa043400.87801364
67Butanoate metabolism_Homo sapiens_hsa006500.87397812
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83890396
69Viral myocarditis_Homo sapiens_hsa054160.83721447
70Homologous recombination_Homo sapiens_hsa034400.83113873
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83061892
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81653840
73Axon guidance_Homo sapiens_hsa043600.81622810
74mTOR signaling pathway_Homo sapiens_hsa041500.79306932
75N-Glycan biosynthesis_Homo sapiens_hsa005100.78520596
76Peroxisome_Homo sapiens_hsa041460.77174445
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75910676
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75718174
79Glycerolipid metabolism_Homo sapiens_hsa005610.72189181
80Glucagon signaling pathway_Homo sapiens_hsa049220.72152901
81Biosynthesis of amino acids_Homo sapiens_hsa012300.69720399
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67792627
83Carbon metabolism_Homo sapiens_hsa012000.67533203
84AMPK signaling pathway_Homo sapiens_hsa041520.67298941
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67134222
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66463962
87beta-Alanine metabolism_Homo sapiens_hsa004100.66399538
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64826912
89Toxoplasmosis_Homo sapiens_hsa051450.64755869
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64670575
91Primary immunodeficiency_Homo sapiens_hsa053400.61446396
92Chemical carcinogenesis_Homo sapiens_hsa052040.60814340
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60802558
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60676508
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.59685158
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59219621
97Platelet activation_Homo sapiens_hsa046110.58801925
98Leishmaniasis_Homo sapiens_hsa051400.58195021
99Selenocompound metabolism_Homo sapiens_hsa004500.57234580
100Phenylalanine metabolism_Homo sapiens_hsa003600.56770673
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56711541
102Pyruvate metabolism_Homo sapiens_hsa006200.56407554
103Pancreatic secretion_Homo sapiens_hsa049720.56227820
104Insulin signaling pathway_Homo sapiens_hsa049100.55541139
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54274919
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53503833
107Amoebiasis_Homo sapiens_hsa051460.52742801
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52510457
109Fatty acid biosynthesis_Homo sapiens_hsa000610.52293861
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.51493581
111Melanoma_Homo sapiens_hsa052180.51083415
112Chronic myeloid leukemia_Homo sapiens_hsa052200.50944536
113Circadian rhythm_Homo sapiens_hsa047100.50162197
114Arachidonic acid metabolism_Homo sapiens_hsa005900.48358991
115Nucleotide excision repair_Homo sapiens_hsa034200.47826449
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47660324
117Vitamin digestion and absorption_Homo sapiens_hsa049770.47576349
118Sulfur relay system_Homo sapiens_hsa041220.46669464
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46630558
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.45182023
121p53 signaling pathway_Homo sapiens_hsa041150.44973797
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44535231
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44196877
124Proteoglycans in cancer_Homo sapiens_hsa052050.43554312
125Inositol phosphate metabolism_Homo sapiens_hsa005620.43453283
126cAMP signaling pathway_Homo sapiens_hsa040240.43411783
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43072729
128GnRH signaling pathway_Homo sapiens_hsa049120.42908077
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42883035
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42781628
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.42622002
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.42539496
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42439939
134FoxO signaling pathway_Homo sapiens_hsa040680.42320625
135Gastric acid secretion_Homo sapiens_hsa049710.42028298
136Oxytocin signaling pathway_Homo sapiens_hsa049210.41959291
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.41601012
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41102151
139Pancreatic cancer_Homo sapiens_hsa052120.40678121
140Focal adhesion_Homo sapiens_hsa045100.40651627
141T cell receptor signaling pathway_Homo sapiens_hsa046600.39844877
142Renin secretion_Homo sapiens_hsa049240.39394648
143Hippo signaling pathway_Homo sapiens_hsa043900.39159363
144TNF signaling pathway_Homo sapiens_hsa046680.38595881
145Galactose metabolism_Homo sapiens_hsa000520.38473962
146Circadian entrainment_Homo sapiens_hsa047130.38409299
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38394168
148Serotonergic synapse_Homo sapiens_hsa047260.37937396
149Fructose and mannose metabolism_Homo sapiens_hsa000510.37839214
150Dorso-ventral axis formation_Homo sapiens_hsa043200.37555100
151Morphine addiction_Homo sapiens_hsa050320.37435625
152Non-small cell lung cancer_Homo sapiens_hsa052230.37380634
153Retinol metabolism_Homo sapiens_hsa008300.37177350
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37099119
155Metabolic pathways_Homo sapiens_hsa011000.36258441
156Hematopoietic cell lineage_Homo sapiens_hsa046400.33110983
157Histidine metabolism_Homo sapiens_hsa003400.32425582
158ECM-receptor interaction_Homo sapiens_hsa045120.32196898
159Olfactory transduction_Homo sapiens_hsa047400.31329767
160RNA polymerase_Homo sapiens_hsa030200.30948376
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28393500
162Wnt signaling pathway_Homo sapiens_hsa043100.26529021

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